CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Rhein
Accession: CHEBI:8825
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Definition: A dihydroxyanthraquinone that has formula C15H8O6.
Synonyms: related_synonym: Formula=C15H8O6; InChI=1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21); InChIKey=FCDLCPWAQCPTKC-UHFFFAOYSA-N; SMILES=OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
xref: CAS:478-43-3; HMDB:HMDB0032876; KEGG:C10401; KNApSAcK:C00002861; LINCS:LSM-20950
xref_mesh: MESH:C020491
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Abcb11
ATP binding cassette subfamily B member 11
multiple interactions
ISO
Enzymes and Coenzymes inhibits the reaction [rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; rhein metabolite inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]
CTD
PMID:35101544
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Acta2
actin alpha 2, smooth muscle
multiple interactions
EXP
rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD
PMID:12546737
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
rhein inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD
PMID:19269596
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Alkbh2
alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
decreases activity
ISO
rhein results in decreased activity of ALKBH2 protein
CTD
PMID:31088072
NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
rhein results in increased expression of BAX protein
CTD
PMID:31436023
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Becn1
beclin 1
decreases expression
ISO
rhein results in decreased expression of BECN1 protein
CTD
PMID:31436023
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Casp3
caspase 3
decreases expression
ISO
rhein results in decreased expression of CASP3 protein
CTD
PMID:31436023
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
increases cleavage
ISO
rhein results in increased cleavage of CASP8 protein
CTD
PMID:31436023
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
decreases expression
ISO
rhein results in decreased expression of CASP9 protein
CTD
PMID:31436023
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
rhein results in decreased activity of CYP1A1 protein
CTD
PMID:27633141
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity
ISO
rhein results in decreased activity of CYP1A2 protein
CTD
PMID:27633141
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Egf
epidermal growth factor
decreases expression
ISO
rhein results in decreased expression of EGF protein
CTD
PMID:21457705
NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
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Erbb2
erb-b2 receptor tyrosine kinase 2
decreases expression
ISO
rhein results in decreased expression of ERBB2 protein
CTD
PMID:21457705
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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Hif1a
hypoxia inducible factor 1 subunit alpha
decreases expression multiple interactions
ISO
rhein results in decreased expression of HIF1A protein rhein inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]
CTD
PMID:21457705
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Ifng
interferon gamma
increases expression multiple interactions
ISO
rhein results in increased expression of IFNG protein rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]
CTD
PMID:26784856
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il10
interleukin 10
multiple interactions
ISO
rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]
CTD
PMID:26784856
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il17a
interleukin 17A
increases expression
ISO
rhein results in increased expression of IL17A protein
CTD
PMID:26784856
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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Il2
interleukin 2
increases expression
ISO
rhein results in increased expression of IL2 protein
CTD
PMID:26784856
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il6
interleukin 6
multiple interactions
ISO
rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD
PMID:26784856
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Nfkb1
nuclear factor kappa B subunit 1
affects localization decreases activity
ISO
rhein affects the localization of NFKB1 protein rhein results in decreased activity of NFKB1 protein
CTD
PMID:21457705
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
rhein results in decreased expression of PTGS2 protein
CTD
PMID:21457705
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
decreases activity multiple interactions affects localization
ISO
rhein results in decreased activity of RELA protein cobaltous chloride promotes the reaction [rhein affects the localization of RELA protein]
CTD
PMID:21457705
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Slc22a6
solute carrier family 22 member 6
multiple interactions
ISO
rhein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of Methotrexate]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
CTD
PMID:28890383
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc22a8
solute carrier family 22 member 8
multiple interactions
ISO
rhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]
CTD
PMID:28890383
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Sqstm1
sequestosome 1
increases expression
ISO
rhein results in increased expression of SQSTM1 protein
CTD
PMID:31436023
NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
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Sult1a1
sulfotransferase family 1A member 1
decreases activity
ISO
rhein results in decreased activity of SULT1A1 protein
CTD
PMID:27633141
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
CTD
PMID:12546737
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
increases expression multiple interactions
ISO
rhein results in increased expression of TNF protein rhein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD
PMID:26784856 PMID:31436023
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tradd
TNFRSF1A-associated via death domain
increases expression
ISO
rhein results in increased expression of TRADD protein
CTD
PMID:31436023
NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
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Traf1
TNF receptor-associated factor 1
increases expression
ISO
rhein results in increased expression of TRAF1 protein
CTD
PMID:31436023
NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
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Vegfa
vascular endothelial growth factor A
decreases expression decreases response to substance
ISO
rhein results in decreased expression of VEGFA protein rhein results in decreased susceptibility to VEGFA protein
CTD
PMID:21457705
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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