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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Rhein
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Accession:CHEBI:8825 term browser browse the term
Definition:A dihydroxyanthraquinone that has formula C15H8O6.
Synonyms:related_synonym: Formula=C15H8O6;   InChI=1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21);   InChIKey=FCDLCPWAQCPTKC-UHFFFAOYSA-N;   SMILES=OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
 xref: CAS:478-43-3;   HMDB:HMDB0032876;   KEGG:C10401;   KNApSAcK:C00002861;   LINCS:LSM-20950
 xref_mesh: MESH:C020491


show annotations for term's descendants           Sort by:
Rhein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO Enzymes and Coenzymes inhibits the reaction [rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; rhein metabolite inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid] CTD PMID:35101544 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:12546737 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO rhein inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO rhein results in decreased activity of ALKBH2 protein CTD PMID:31088072 NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO rhein results in increased expression of BAX protein CTD PMID:31436023 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Becn1 beclin 1 decreases expression ISO rhein results in decreased expression of BECN1 protein CTD PMID:31436023 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 decreases expression ISO rhein results in decreased expression of CASP3 protein CTD PMID:31436023 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO rhein results in increased cleavage of CASP8 protein CTD PMID:31436023 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 decreases expression ISO rhein results in decreased expression of CASP9 protein CTD PMID:31436023 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO rhein results in decreased activity of CYP1A1 protein CTD PMID:27633141 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO rhein results in decreased activity of CYP1A2 protein CTD PMID:27633141 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Egf epidermal growth factor decreases expression ISO rhein results in decreased expression of EGF protein CTD PMID:21457705 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO rhein results in decreased expression of ERBB2 protein CTD PMID:21457705 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions		 ISO rhein results in decreased expression of HIF1A protein
rhein inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]		 CTD PMID:21457705 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Ifng interferon gamma increases expression
multiple interactions		 ISO rhein results in increased expression of IFNG protein
rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]		 CTD PMID:26784856 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein] CTD PMID:26784856 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il17a interleukin 17A increases expression ISO rhein results in increased expression of IL17A protein CTD PMID:26784856 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il2 interleukin 2 increases expression ISO rhein results in increased expression of IL2 protein CTD PMID:26784856 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:26784856 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization
decreases activity		 ISO rhein affects the localization of NFKB1 protein
rhein results in decreased activity of NFKB1 protein		 CTD PMID:21457705 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO rhein results in decreased expression of PTGS2 protein CTD PMID:21457705 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity
multiple interactions
affects localization		 ISO rhein results in decreased activity of RELA protein
cobaltous chloride promotes the reaction [rhein affects the localization of RELA protein]		 CTD PMID:21457705 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO rhein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of Methotrexate]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:28890383 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO rhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate] CTD PMID:28890383 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO rhein results in increased expression of SQSTM1 protein CTD PMID:31436023 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO rhein results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:12546737 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO rhein results in increased expression of TNF protein
rhein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]		 CTD PMID:26784856 PMID:31436023 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO rhein results in increased expression of TRADD protein CTD PMID:31436023 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO rhein results in increased expression of TRAF1 protein CTD PMID:31436023 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
decreases response to substance		 ISO rhein results in decreased expression of VEGFA protein
rhein results in decreased susceptibility to VEGFA protein		 CTD PMID:21457705 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    chemical entity 19738
      molecular entity 19738
        polyatomic entity 19698
          heteroatomic molecular entity 19650
            hydroxides 19255
              organic hydroxy compound 18867
                phenols 18567
                  hydroxyanthraquinones 498
                    dihydroxyanthraquinone 341
                      Rhein 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      ketone 17109
                                        cyclic ketone 15669
                                          quinone 8533
                                            acenoquinone 7605
                                              anthraquinone 509
                                                hydroxyanthraquinones 498
                                                  dihydroxyanthraquinone 341
                                                    Rhein 31
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