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ONTOLOGY REPORT - ANNOTATIONS


Term:PD 0325901
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Accession:CHEBI:88249 term browser browse the term
Definition:A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position 2 by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer).
Synonyms:exact_synonym: N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
 related_synonym: Formula=C16H14F3IN2O4;   InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1;   InChIKey=SUDAHWBOROXANE-SECBINFHSA-N;   PD-325901;   PD0325901;   SMILES=C1(=CC=C(C(=C1NC=2C(=CC(=CC2)I)F)F)F)C(NOC[C@@H](CO)O)=O
 xref: CAS:391210-10-9 "ChemIDplus";   LINCS:LSM-1101
 xref_mesh: MESH:C506614
 xref: PMID:16944149 "Europe PMC";   PMID:18651802 "Europe PMC";   PMID:18952427 "Europe PMC";   PMID:19929595 "Europe PMC";   PMID:20215549 "Europe PMC";   PMID:20332327 "Europe PMC";   PMID:20587665 "Europe PMC";   PMID:21516509 "Europe PMC";   PMID:22752429 "Europe PMC";   PMID:24269278 "Europe PMC";   PMID:25031379 "Europe PMC";   PMID:25195567 "Europe PMC";   PMID:25798061 "Europe PMC";   PMID:25907661 "Europe PMC";   PMID:25977343 "Europe PMC";   Reaxys:11343179 "Reaxys"


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PD 0325901 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam19 ADAM metallopeptidase domain 19 JBrowse link 10 31,146,107 31,240,582 RGD:6480464
G Adamts6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 JBrowse link 2 34,374,142 34,589,676 RGD:6480464
G Akap12 A-kinase anchoring protein 12 JBrowse link 1 40,816,130 40,906,582 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Ank3 ankyrin 3 JBrowse link 20 19,948,767 20,480,628 RGD:6480464
G Ano1 anoctamin 1 JBrowse link 1 217,754,349 217,902,540 RGD:6480464
G Anpep alanyl aminopeptidase, membrane JBrowse link 1 141,561,364 141,604,249 RGD:6480464
G Arhgap24 Rho GTPase activating protein 24 JBrowse link 14 8,383,211 8,600,526 RGD:6480464
G Arl4c ADP ribosylation factor like GTPase 4C JBrowse link 9 95,783,651 95,787,092 RGD:6480464
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:6480464
G Ccl20 C-C motif chemokine ligand 20 JBrowse link 9 88,918,359 88,921,017 RGD:6480464
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:6480464
G Cxcl3 chemokine (C-X-C motif) ligand 3 JBrowse link 14 18,820,168 18,839,659 RGD:6480464
G Cyb5r2 cytochrome b5 reductase 2 JBrowse link 1 171,971,424 171,981,586 RGD:6480464
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 JBrowse link 3 168,097,484 168,111,920 RGD:6480464
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 JBrowse link 7 70,333,150 70,340,006 RGD:6480464
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6480464
G Dcbld2 discoidin, CUB and LCCL domain containing 2 JBrowse link 11 44,237,814 44,292,884 RGD:6480464
G Dnmbp dynamin binding protein JBrowse link 1 263,625,503 263,718,784 RGD:6480464
G Dock4 dedicator of cytokinesis 4 JBrowse link 6 60,374,839 60,782,648 RGD:6480464
G Dusp4 dual specificity phosphatase 4 JBrowse link 16 61,080,767 61,090,973 RGD:6480464
G Dusp6 dual specificity phosphatase 6 JBrowse link 7 41,475,163 41,479,393 RGD:6480464
G Efna5 ephrin A5 JBrowse link 9 110,054,002 110,329,878 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:6480464
G Emp1 epithelial membrane protein 1 JBrowse link 4 169,161,076 169,181,967 RGD:6480464
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:6480464
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit JBrowse link 10 2,010,140 2,037,953 RGD:6480464
G Esm1 endothelial cell-specific molecule 1 JBrowse link 2 45,104,392 45,113,130 RGD:6480464
G Ets1 ETS proto-oncogene 1, transcription factor JBrowse link 8 33,756,634 33,879,625 RGD:6480464
G Etv1 ETS variant transcription factor 1 JBrowse link 6 58,467,215 58,558,640 RGD:6480464
G Etv4 ETS variant transcription factor 4 JBrowse link 10 89,685,058 89,700,300 RGD:6480464
G Etv5 ETS variant transcription factor 5 JBrowse link 11 82,194,657 82,252,145 RGD:6480464
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6480464
G Fgf23 fibroblast growth factor 23 JBrowse link 4 159,622,404 159,630,082 RGD:6480464
G Fmnl2 formin-like 2 JBrowse link 3 38,400,409 38,677,637 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Foxg1 forkhead box G1 JBrowse link 6 69,971,227 69,974,037 RGD:6480464
G Glrx glutaredoxin JBrowse link 2 2,606,032 2,615,944 RGD:6480464
G Gypc glycophorin C (Gerbich blood group) JBrowse link 18 25,312,386 25,344,614 RGD:6480464
G Has2 hyaluronan synthase 2 JBrowse link 7 96,438,046 96,464,049 RGD:6480464
G Hdac9 histone deacetylase 9 JBrowse link 6 53,487,367 54,358,694 RGD:6480464
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 JBrowse link 19 50,246,404 50,317,892 RGD:6480464
G Htr7 5-hydroxytryptamine receptor 7 JBrowse link 1 254,547,964 254,671,811 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Igfbp3 insulin-like growth factor binding protein 3 JBrowse link 14 87,457,647 87,465,374 RGD:6480464
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:6480464
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il1rapl1 interleukin 1 receptor accessory protein-like 1 JBrowse link X 55,439,388 57,004,865 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Inhba inhibin subunit beta A JBrowse link 17 51,894,869 51,919,998 RGD:6480464
G Itga2 integrin subunit alpha 2 JBrowse link 2 46,996,904 47,097,011 RGD:6480464
G Itgbl1 integrin subunit beta like 1 JBrowse link 15 110,114,148 110,378,970 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Kif24 kinesin family member 24 JBrowse link 5 57,778,730 57,845,642 RGD:6480464
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:6480464
G Klrk1 killer cell lectin like receptor K1 JBrowse link 4 163,392,652 163,403,735 RGD:6480464
G LOC100362814 hypothetical protein LOC100362814 JBrowse link 3 94,058,546 94,334,805 RGD:6480464
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:6480464
G Lpxn leupaxin JBrowse link 1 229,642,437 229,674,129 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mgll monoglyceride lipase JBrowse link 4 120,671,436 120,773,458 RGD:6480464
G Mmd monocyte to macrophage differentiation-associated JBrowse link 10 77,687,964 77,783,737 RGD:6480464
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6480464
G Mmp10 matrix metallopeptidase 10 JBrowse link 8 5,734,348 5,742,243 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Nav3 neuron navigator 3 JBrowse link 7 52,164,805 52,508,145 RGD:6480464
G Ncr3 natural cytotoxicity triggering receptor 3 JBrowse link 20 5,170,169 5,175,773 RGD:6480464
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:6480464
G Nme5 NME/NM23 family member 5 JBrowse link 18 27,357,460 27,374,641 RGD:6480464
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 JBrowse link 5 151,776,004 151,779,319 RGD:6480464
G Nrcam neuronal cell adhesion molecule JBrowse link 6 64,297,843 64,867,408 RGD:6480464
G Nrp1 neuropilin 1 JBrowse link 19 61,332,351 61,486,166 RGD:6480464
G Ntm neurotrimin JBrowse link 8 30,039,332 31,041,755 RGD:6480464
G Pdcd1lg2 programmed cell death 1 ligand 2 JBrowse link 1 247,562,202 247,629,279 RGD:6480464
G Peg3 paternally expressed 3 JBrowse link 1 70,210,810 70,237,450 RGD:6480464
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:6480464
G Plaur plasminogen activator, urokinase receptor JBrowse link 1 81,328,171 81,344,954 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Prdm1 PR/SET domain 1 JBrowse link 20 49,464,921 49,556,623 RGD:6480464
G Prrx1 paired related homeobox 1 JBrowse link 13 81,147,038 81,215,559 RGD:6480464
G Ptx3 pentraxin 3 JBrowse link 2 158,097,843 158,103,653 RGD:6480464
G Reln reelin JBrowse link 4 9,347,533 9,774,257 RGD:6480464
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:6480464
G Scg5 secretogranin V JBrowse link 3 105,235,065 105,279,475 RGD:6480464
G Sema3a semaphorin 3A JBrowse link 4 18,170,375 18,545,190 RGD:6480464
G Siglec15 sialic acid binding Ig-like lectin 15 JBrowse link 18 74,403,384 74,417,333 RGD:6480464
G Slc6a15 solute carrier family 6 member 15 JBrowse link 7 45,328,207 45,381,920 RGD:6480464
G Slit2 slit guidance ligand 2 JBrowse link 14 66,831,848 67,171,491 RGD:6480464
G Sox9 SRY-box transcription factor 9 JBrowse link 10 101,288,528 101,294,030 RGD:6480464
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:6480464
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link 15 90,172,769 90,177,823 RGD:6480464
G St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 JBrowse link 11 44,176,518 44,237,119 RGD:6480464
G Stc1 stanniocalcin 1 JBrowse link 15 50,891,137 50,901,791 RGD:6480464
G Stx1a syntaxin 1A JBrowse link 12 24,682,050 24,710,002 RGD:6480464
G Suz12 SUZ12 polycomb repressive complex 2 subunit JBrowse link 10 67,325,101 67,371,588 RGD:6480464
G Tbx3 T-box transcription factor 3 JBrowse link 12 42,479,518 42,494,588 RGD:6480464
G Tfpi tissue factor pathway inhibitor JBrowse link 3 71,852,738 71,902,127 RGD:6480464
G Tgm2 transglutaminase 2 JBrowse link 3 154,597,165 154,627,257 RGD:6480464
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:6480464
G Tmem156 transmembrane protein 156 JBrowse link 14 44,888,902 44,918,377 RGD:6480464
G Tnfsf15 TNF superfamily member 15 JBrowse link 5 79,553,935 79,569,974 RGD:6480464
G Trib2 tribbles pseudokinase 2 JBrowse link 6 41,016,722 41,040,972 RGD:6480464
G Ucp1 uncoupling protein 1 JBrowse link 19 24,456,976 24,464,808 RGD:6480464
G Ugt8 UDP glycosyltransferase 8 JBrowse link 2 229,644,373 229,718,678 RGD:6480464
G Vegfc vascular endothelial growth factor C JBrowse link 16 40,440,371 40,555,178 RGD:6480464
G Zeb1 zinc finger E-box binding homeobox 1 JBrowse link 17 54,656,627 54,714,920 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      application 19232
        pharmaceutical 19094
          drug 19094
            antineoplastic agent 16568
              PD 0325901 111
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        carboacyl group 16944
                                          univalent carboacyl group 16944
                                            carbamoyl group 16623
                                              carboxamide 16623
                                                hydroxamic acid 6245
                                                  hydroxamic acid ester 128
                                                    PD 0325901 111
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.