Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:PD 0325901
go back to main search page
Accession:CHEBI:88249 term browser browse the term
Definition:A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position 2 by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer).
Synonyms:exact_synonym: N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
 related_synonym: Formula=C16H14F3IN2O4;   InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1;   InChIKey=SUDAHWBOROXANE-SECBINFHSA-N;   PD-325901;   PD0325901;   SMILES=C1(=CC=C(C(=C1NC=2C(=CC(=CC2)I)F)F)F)C(NOC[C@@H](CO)O)=O
 xref: CAS:391210-10-9;   LINCS:LSM-1101
 xref_mesh: MESH:C506614
 xref: PMID:16944149;   PMID:18651802;   PMID:18952427;   PMID:19929595;   PMID:20215549;   PMID:20332327;   PMID:20587665;   PMID:21516509;   PMID:22752429;   PMID:24269278;   PMID:25031379;   PMID:25195567;   PMID:25798061;   PMID:25907661;   PMID:25977343;   Reaxys:11343179


show annotations for term's descendants           Sort by:
 
PD 0325901 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam19 ADAM metallopeptidase domain 19 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of ADAM19 mRNA
[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ADAM19 mRNA
CTD PMID:25119042 NCBI chr10:31,146,107...31,240,582
Ensembl chr10:31,146,107...31,240,582
JBrowse link
G Adamts6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ADAMTS6 mRNA CTD PMID:25119042 NCBI chr 2:34,374,142...34,589,676
Ensembl chr 2:34,374,158...34,586,755
JBrowse link
G Akap12 A-kinase anchoring protein 12 decreases expression ISO PD 0325901 results in decreased expression of AKAP12 mRNA CTD PMID:25119042 NCBI chr 1:40,816,130...40,906,582
Ensembl chr 1:40,816,107...40,906,581
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO [PD 0325901 co-treated with 5-(3-chlorophenylamino)benzo(c)(2,6)naphthyridine-8-carboxylic acid] results in decreased phosphorylation of AKT1 protein; [PD 0325901 co-treated with MK 2206] results in increased phosphorylation of AKT1 protein; PD 0325901 promotes the reaction [dactolisib results in decreased phosphorylation of AKT1 protein]; romidepsin inhibits the reaction [[PD 0325901 co-treated with MK 2206] results in increased phosphorylation of AKT1 protein]
PD 0325901 results in increased phosphorylation of AKT1 protein
CTD PMID:22415236, PMID:25798061, PMID:27634878 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin decreases expression EXP PD 0325901 results in decreased expression of ALB protein CTD PMID:21976371 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ank3 ankyrin 3 multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ANK3 mRNA CTD PMID:25119042 NCBI chr20:19,948,767...20,480,628
Ensembl chr20:20,105,047...20,480,623
JBrowse link
G Ano1 anoctamin 1 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of ANO1 mRNA
[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ANO1 mRNA
CTD PMID:25119042 NCBI chr 1:217,754,349...217,902,540
Ensembl chr 1:217,754,336...217,902,473
JBrowse link
G Anpep alanyl aminopeptidase, membrane decreases expression ISO PD 0325901 results in decreased expression of ANPEP mRNA CTD PMID:25119042 NCBI chr 1:141,561,364...141,604,249
Ensembl chr 1:141,561,334...141,604,273
JBrowse link
G Arhgap24 Rho GTPase activating protein 24 multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ARHGAP24 mRNA CTD PMID:25119042 NCBI chr14:8,383,211...8,600,526
Ensembl chr14:8,383,214...8,600,512
JBrowse link
G Arl4c ADP ribosylation factor like GTPase 4C decreases expression ISO PD 0325901 results in decreased expression of ARL4C mRNA CTD PMID:25119042 NCBI chr 9:95,783,651...95,787,092
Ensembl chr 9:95,786,508...95,787,094
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
multiple interactions
ISO PD 0325901 results in increased expression of BAK1 protein
[PD 0325901 co-treated with MK 2206] results in increased expression of BAK1 protein; [romidepsin co-treated with PD 0325901 co-treated with MK 2206] results in increased expression of BAK1 protein; [romidepsin co-treated with PD 0325901] results in increased expression of BAK1 protein
CTD PMID:27634878 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression
ISO [PD 0325901 co-treated with MK 2206] results in increased expression of BCL2L11 protein; [romidepsin co-treated with PD 0325901 co-treated with MK 2206] results in increased expression of BCL2L11 protein; [romidepsin co-treated with PD 0325901] results in increased expression of BCL2L11 protein; KRAS protein affects the reaction [NVP-BKM120 promotes the reaction [PD 0325901 results in increased expression of BCL2L11 protein]]; KRAS protein affects the reaction [PD 0325901 results in increased expression of BCL2L11 protein]; NVP-BKM120 promotes the reaction [PD 0325901 results in increased expression of BCL2L11 protein] CTD PMID:24576621, PMID:27634878 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [PD 0325901 co-treated with MK 2206] results in increased expression of BID mRNA; [PD 0325901 co-treated with MK 2206] results in increased expression of BID protein modified form CTD PMID:28691888 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of BIRC3 mRNA CTD PMID:25119042 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of CCL20 mRNA
PD 0325901 results in decreased expression of CCL20 mRNA
CTD PMID:25119042 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO PD 0325901 inhibits the reaction [camostat results in increased expression of CCND1 protein] CTD PMID:25104499 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO PD 0325901 inhibits the reaction [camostat results in increased expression of CCND3 protein] CTD PMID:25104499 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO PD 0325901 inhibits the reaction [camostat results in increased expression of CCNE1 protein] CTD PMID:25104499 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of CXCL1 mRNA
PD 0325901 results in decreased expression of CXCL1 mRNA
CTD PMID:25119042 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of CXCL1 mRNA
PD 0325901 results in decreased expression of CXCL1 mRNA
CTD PMID:25119042 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyb5r2 cytochrome b5 reductase 2 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of CYB5R2 mRNA
PD 0325901 results in decreased expression of CYB5R2 mRNA
CTD PMID:25119042 NCBI chr 1:171,971,424...171,981,586
Ensembl chr 1:171,971,701...171,979,933
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression
increases expression
EXP PD 0325901 results in decreased expression of CYP24A1 mRNA
PD 0325901 results in increased expression of CYP24A1 mRNA
CTD PMID:21976371, PMID:23872713 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 increases expression EXP PD 0325901 results in increased expression of CYP27B1 mRNA CTD PMID:21976371 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression ISO PD 0325901 results in increased expression of CYP3A5 mRNA CTD PMID:24819614 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dcbld2 discoidin, CUB and LCCL domain containing 2 decreases expression ISO PD 0325901 results in decreased expression of DCBLD2 mRNA CTD PMID:25119042 NCBI chr11:44,237,814...44,292,884
Ensembl chr11:44,241,111...44,292,884
JBrowse link
G Dnmbp dynamin binding protein decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of DNMBP mRNA
[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of DNMBP mRNA
CTD PMID:25119042 NCBI chr 1:263,625,503...263,718,784
Ensembl chr 1:263,625,501...263,718,745
JBrowse link
G Dock4 dedicator of cytokinesis 4 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of DOCK4 mRNA
PD 0325901 results in decreased expression of DOCK4 mRNA
CTD PMID:25119042 NCBI chr 6:60,374,839...60,782,648
Ensembl chr 6:60,566,196...60,782,556
JBrowse link
G Dusp4 dual specificity phosphatase 4 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of DUSP4 mRNA
[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of DUSP4 mRNA
CTD PMID:25119042 NCBI chr16:61,080,767...61,090,973
Ensembl chr16:61,078,175...61,091,169
JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of DUSP6 mRNA
PD 0325901 results in decreased expression of DUSP6 mRNA
CTD PMID:25119042 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Efna5 ephrin A5 multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of EFNA5 mRNA CTD PMID:25119042 NCBI chr 9:110,054,002...110,329,878
Ensembl chr 9:110,057,155...110,225,486
JBrowse link
G Egr1 early growth response 1 decreases expression
multiple interactions
EXP
ISO
PD 0325901 results in decreased expression of EGR1 mRNA
PD 0325901 inhibits the reaction [camostat results in increased expression of EGR1 mRNA]
CTD PMID:21976371, PMID:25104499 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Ku 0063794 co-treated with PD 0325901] results in decreased phosphorylation of EIF4EBP1 protein; PD 0325901 promotes the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:22415236 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Emp1 epithelial membrane protein 1 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of EMP1 mRNA
PD 0325901 results in decreased expression of EMP1 mRNA
CTD PMID:25119042 NCBI chr 4:169,161,076...169,181,967
Ensembl chr 4:169,147,243...169,181,966
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions
decreases expression
ISO PD 0325901 inhibits the reaction [Cisplatin results in increased expression of ERCC1 mRNA]; PD 0325901 inhibits the reaction [Cisplatin results in increased expression of ERCC1 protein]
PD 0325901 results in decreased expression of ERCC1 mRNA
CTD PMID:21996734 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit increases expression ISO PD 0325901 results in increased expression of ERCC4 mRNA CTD PMID:21996734 NCBI chr10:2,010,140...2,037,953
Ensembl chr10:2,010,648...2,037,891
JBrowse link
G Esm1 endothelial cell-specific molecule 1 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ESM1 mRNA
PD 0325901 results in decreased expression of ESM1 mRNA
CTD PMID:25119042 NCBI chr 2:45,104,392...45,113,130
Ensembl chr 2:45,104,305...45,113,131
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ETS1 mRNA CTD PMID:25119042 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625
JBrowse link
G Etv1 ETS variant transcription factor 1 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ETV1 mRNA
PD 0325901 results in decreased expression of ETV1 mRNA
CTD PMID:25119042 NCBI chr 6:58,467,215...58,558,640
Ensembl chr 6:58,467,254...58,558,631
JBrowse link
G Etv4 ETS variant transcription factor 4 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ETV4 mRNA
PD 0325901 results in decreased expression of ETV4 mRNA
CTD PMID:25119042 NCBI chr10:89,685,058...89,700,300
Ensembl chr10:89,685,058...89,700,283
JBrowse link
G Etv5 ETS variant transcription factor 5 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ETV5 mRNA
PD 0325901 results in decreased expression of ETV5 mRNA
CTD PMID:25119042 NCBI chr11:82,194,657...82,252,145
Ensembl chr11:82,194,657...82,252,139
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO PD 0325901 inhibits the reaction [Protein Kinase Inhibitors inhibits the reaction [FASN protein results in increased expression of UCP1 protein]] CTD PMID:26670611 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fgf23 fibroblast growth factor 23 multiple interactions EXP PD 0325901 inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK1 protein]; PD 0325901 inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK3 protein]; PD 0325901 results in increased expression of and results in increased secretion of FGF23 protein CTD PMID:23872713 NCBI chr 4:159,622,404...159,630,082
Ensembl chr 4:159,622,404...159,630,082
JBrowse link
G Fmnl2 formin-like 2 decreases expression ISO PD 0325901 results in decreased expression of FMNL2 mRNA CTD PMID:25119042 NCBI chr 3:38,400,409...38,677,637
Ensembl chr 3:38,559,914...38,675,878
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
EXP
ISO
PD 0325901 results in decreased expression of FOS mRNA
PD 0325901 inhibits the reaction [camostat results in increased expression of FOS mRNA]
CTD PMID:21976371, PMID:25104499 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of FOSL1 protein
[PD 0325901 co-treated with 5-(3-chlorophenylamino)benzo(c)(2,6)naphthyridine-8-carboxylic acid] results in decreased expression of FOSL1 protein
CTD PMID:25798061 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Foxg1 forkhead box G1 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of FOXG1 mRNA
[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of FOXG1 mRNA
CTD PMID:25119042 NCBI chr 6:69,971,227...69,974,037
Ensembl chr 6:69,971,227...69,974,037
JBrowse link
G Foxo3 forkhead box O3 increases expression
multiple interactions
ISO PD 0325901 results in increased expression of FOXO3 protein
PD 0325901 inhibits the reaction [Luteolin results in increased phosphorylation of FOXO3 protein]; PD 0325901 promotes the reaction [Luteolin results in increased expression of FOXO3 protein]
CTD PMID:32268164 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Glrx glutaredoxin multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of GLRX mRNA
PD 0325901 results in decreased expression of GLRX mRNA
CTD PMID:25119042 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Gypc glycophorin C (Gerbich blood group) multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of GYPC mRNA
PD 0325901 results in decreased expression of GYPC mRNA
CTD PMID:25119042 NCBI chr18:25,312,386...25,344,614
Ensembl chr18:25,312,387...25,344,614
JBrowse link
G Has2 hyaluronan synthase 2 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of HAS2 mRNA
PD 0325901 results in decreased expression of HAS2 mRNA
CTD PMID:25119042 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Hdac9 histone deacetylase 9 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of HDAC9 mRNA
[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of HDAC9 mRNA
CTD PMID:25119042 NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of HSD17B2 mRNA
PD 0325901 results in decreased expression of HSD17B2 mRNA
CTD PMID:25119042 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of HTR7 mRNA
PD 0325901 results in decreased expression of HTR7 mRNA
CTD PMID:25119042 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Ifng interferon gamma multiple interactions ISO PD 0325901 inhibits the reaction [[IL15 protein co-treated with IL18 protein] results in increased secretion of IFNG protein]; PD 0325901 inhibits the reaction [IL15 protein results in increased secretion of IFNG protein]; PD 0325901 inhibits the reaction [IL2 protein results in increased secretion of IFNG protein] CTD PMID:27563819 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of IGFBP3 mRNA CTD PMID:25119042 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il15 interleukin 15 multiple interactions ISO PD 0325901 inhibits the reaction [[IL15 protein co-treated with IL18 protein] results in increased secretion of IFNG protein]; PD 0325901 inhibits the reaction [IL15 protein results in increased expression of KLRK1 protein]; PD 0325901 inhibits the reaction [IL15 protein results in increased expression of NCR3 protein]; PD 0325901 inhibits the reaction [IL15 protein results in increased secretion of IFNG protein] CTD PMID:27563819 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il18 interleukin 18 multiple interactions ISO PD 0325901 inhibits the reaction [[IL15 protein co-treated with IL18 protein] results in increased secretion of IFNG protein] CTD PMID:27563819 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of IL1B mRNA
PD 0325901 results in decreased expression of IL1B mRNA
CTD PMID:25119042 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rapl1 interleukin 1 receptor accessory protein-like 1 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of IL1RAPL1 mRNA
[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of IL1RAPL1 mRNA
CTD PMID:25119042 NCBI chr  X:55,439,388...57,004,865
Ensembl chr  X:55,439,578...56,765,893
JBrowse link
G Il2 interleukin 2 multiple interactions ISO PD 0325901 inhibits the reaction [IL2 protein results in increased expression of KLRK1 protein]; PD 0325901 inhibits the reaction [IL2 protein results in increased expression of NCR3 protein]; PD 0325901 inhibits the reaction [IL2 protein results in increased secretion of IFNG protein] CTD PMID:27563819 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Inhba inhibin subunit beta A multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of INHBA mRNA CTD PMID:25119042 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ITGA2 mRNA
PD 0325901 results in decreased expression of ITGA2 mRNA
CTD PMID:25119042 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itgbl1 integrin subunit beta like 1 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ITGBL1 mRNA
PD 0325901 results in decreased expression of ITGBL1 mRNA
CTD PMID:25119042 NCBI chr15:110,114,148...110,378,970
Ensembl chr15:110,114,148...110,378,969
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP PD 0325901 results in decreased expression of JUN mRNA CTD PMID:21976371 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kif24 kinesin family member 24 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of KIF24 mRNA
PD 0325901 results in decreased expression of KIF24 mRNA
CTD PMID:25119042 NCBI chr 5:57,778,730...57,845,642
Ensembl chr 5:57,780,389...57,845,509
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of KIT mRNA
PD 0325901 results in decreased expression of KIT mRNA
CTD PMID:25119042 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Klrk1 killer cell lectin like receptor K1 multiple interactions ISO PD 0325901 inhibits the reaction [IL15 protein results in increased expression of KLRK1 protein]; PD 0325901 inhibits the reaction [IL2 protein results in increased expression of KLRK1 protein] CTD PMID:27563819 NCBI chr 4:163,392,652...163,403,735
Ensembl chr 4:163,393,217...163,403,653
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO KRAS protein affects the reaction [NVP-BKM120 inhibits the reaction [PD 0325901 results in increased phosphorylation of MAPK1 protein]]; KRAS protein affects the reaction [NVP-BKM120 promotes the reaction [PD 0325901 results in decreased expression of MCL1 protein]]; KRAS protein affects the reaction [NVP-BKM120 promotes the reaction [PD 0325901 results in increased expression of BCL2L11 protein]]; KRAS protein affects the reaction [PD 0325901 inhibits the reaction [NVP-BKM120 results in increased phosphorylation of MAPK1 protein]]; KRAS protein affects the reaction [PD 0325901 promotes the reaction [NVP-BKM120 results in decreased expression of MCL1 protein]]; KRAS protein affects the reaction [PD 0325901 results in decreased expression of MCL1 protein]; KRAS protein affects the reaction [PD 0325901 results in decreased phosphorylation of MAPK1 protein]; KRAS protein affects the reaction [PD 0325901 results in decreased phosphorylation of MAPK3 protein]; KRAS protein affects the reaction [PD 0325901 results in increased expression of BCL2L11 protein]; KRAS protein affects the susceptibility to [[PD 0325901 co-treated with NVP-BKM120] results in increased cleavage of PARP1 protein]; KRAS protein affects the susceptibility to [PD 0325901 co-treated with NVP-BKM120]
[PD 0325901 affects the susceptibility to KRAS protein] affects the reaction [NVP-BKM120 results in decreased expression of MKI67 protein]
CTD PMID:24576621 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G LOC100362814 hypothetical protein LOC100362814 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of KIAA1549L mRNA
[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of KIAA1549L mRNA
CTD PMID:25119042 NCBI chr 3:94,058,546...94,334,805
Ensembl chr 3:94,064,234...94,182,714
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of LPL mRNA CTD PMID:25119042 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lpxn leupaxin multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of LPXN mRNA
PD 0325901 results in decreased expression of LPXN mRNA
CTD PMID:25119042 NCBI chr 1:229,642,437...229,674,129
Ensembl chr 1:229,642,412...229,674,134
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO PD 0325901 inhibits the reaction [Luteolin results in increased expression of and results in increased lipidation of MAP1LC3B protein] CTD PMID:32268164 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [PD 0325901 results in decreased phosphorylation of MAPK1 protein]; [MK 2206 co-treated with PD 0325901] results in decreased phosphorylation of MAPK1 protein; [PD 0325901 co-treated with 5-(3-chlorophenylamino)benzo(c)(2,6)naphthyridine-8-carboxylic acid] results in decreased phosphorylation of MAPK1 protein; dactolisib promotes the reaction [PD 0325901 results in decreased phosphorylation of MAPK1 protein]; KRAS protein affects the reaction [NVP-BKM120 inhibits the reaction [PD 0325901 results in increased phosphorylation of MAPK1 protein]]; KRAS protein affects the reaction [PD 0325901 inhibits the reaction [NVP-BKM120 results in increased phosphorylation of MAPK1 protein]]; KRAS protein affects the reaction [PD 0325901 results in decreased phosphorylation of MAPK1 protein]; PD 0325901 inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PD 0325901 inhibits the reaction [Luteolin results in increased phosphorylation of MAPK1 protein]; PD 0325901 inhibits the reaction [NVP-BKM120 results in increased phosphorylation of MAPK1 protein]; PD 0325901 promotes the reaction [Axitinib results in decreased phosphorylation of MAPK1 protein]; PD 0325901 promotes the reaction [pazopanib results in decreased phosphorylation of MAPK1 protein]; PD 0325901 promotes the reaction [Sunitinib results in decreased phosphorylation of MAPK1 protein]
PD 0325901 inhibits the reaction [camostat results in increased phosphorylation of MAPK1 protein]; PD 0325901 inhibits the reaction [MTOR gene mutant form results in increased phosphorylation of MAPK1 protein]
PD 0325901 inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:21996734, PMID:22415236, PMID:23872713, PMID:24011934, PMID:24576621, PMID:25104499, PMID:25798061, PMID:27560553, PMID:27634878, PMID:29384525, PMID:32268164 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO
EXP
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [PD 0325901 results in decreased phosphorylation of MAPK3 protein]; [MK 2206 co-treated with PD 0325901] results in decreased phosphorylation of MAPK3 protein; [PD 0325901 co-treated with 5-(3-chlorophenylamino)benzo(c)(2,6)naphthyridine-8-carboxylic acid] results in decreased phosphorylation of MAPK3 protein; dactolisib promotes the reaction [PD 0325901 results in decreased phosphorylation of MAPK3 protein]; KRAS protein affects the reaction [PD 0325901 results in decreased phosphorylation of MAPK3 protein]; PD 0325901 inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; PD 0325901 inhibits the reaction [Luteolin results in increased phosphorylation of MAPK3 protein]; PD 0325901 inhibits the reaction [NVP-BKM120 results in increased phosphorylation of MAPK3 protein]; PD 0325901 promotes the reaction [Axitinib results in decreased phosphorylation of MAPK3 protein]; PD 0325901 promotes the reaction [pazopanib results in decreased phosphorylation of MAPK3 protein]; PD 0325901 promotes the reaction [Sunitinib results in decreased phosphorylation of MAPK3 protein]
PD 0325901 inhibits the reaction [camostat results in increased phosphorylation of MAPK3 protein]; PD 0325901 inhibits the reaction [MTOR gene mutant form results in increased phosphorylation of MAPK3 protein]
PD 0325901 inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:21996734, PMID:22415236, PMID:23872713, PMID:24011934, PMID:24576621, PMID:25104499, PMID:25798061, PMID:27560553, PMID:27634878, PMID:29384525, PMID:32268164 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression
increases expression
ISO [PD 0325901 co-treated with MK 2206] results in increased expression of MCL1 protein; [romidepsin co-treated with PD 0325901 co-treated with MK 2206] results in increased expression of MCL1 protein; [romidepsin co-treated with PD 0325901] results in increased expression of MCL1 protein; KRAS protein affects the reaction [NVP-BKM120 promotes the reaction [PD 0325901 results in decreased expression of MCL1 protein]]; KRAS protein affects the reaction [PD 0325901 promotes the reaction [NVP-BKM120 results in decreased expression of MCL1 protein]]; KRAS protein affects the reaction [PD 0325901 results in decreased expression of MCL1 protein]; NVP-BKM120 promotes the reaction [PD 0325901 results in decreased expression of MCL1 protein]; PD 0325901 promotes the reaction [NVP-BKM120 results in decreased expression of MCL1 protein]
PD 0325901 results in increased expression of MCL1 protein
CTD PMID:24576621, PMID:27634878 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mgll monoglyceride lipase multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of MGLL mRNA
PD 0325901 results in decreased expression of MGLL mRNA
CTD PMID:25119042 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [PD 0325901 affects the susceptibility to KRAS protein] affects the reaction [NVP-BKM120 results in decreased expression of MKI67 protein]; PD 0325901 inhibits the reaction [camostat results in increased expression of MKI67 protein] CTD PMID:24576621, PMID:25104499 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmd monocyte to macrophage differentiation-associated multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of MMD mRNA
PD 0325901 results in decreased expression of MMD mRNA
CTD PMID:25119042 NCBI chr10:77,687,964...77,783,737
Ensembl chr10:77,755,216...77,783,779
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of MMP1 mRNA
PD 0325901 results in decreased expression of MMP1 mRNA
CTD PMID:25119042 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp10 matrix metallopeptidase 10 multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of MMP10 mRNA CTD PMID:25119042 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO PD 0325901 inhibits the reaction [MTOR gene mutant form results in increased phosphorylation of MAPK1 protein]; PD 0325901 inhibits the reaction [MTOR gene mutant form results in increased phosphorylation of MAPK3 protein] CTD PMID:29384525 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [PD 0325901 results in decreased expression of MYC protein]; PD 0325901 promotes the reaction [(+)-JQ1 compound results in decreased expression of MYC protein] CTD PMID:26284497 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nav3 neuron navigator 3 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of NAV3 mRNA
[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of NAV3 mRNA
CTD PMID:25119042 NCBI chr 7:52,164,805...52,508,145
Ensembl chr 7:52,165,233...52,404,774
JBrowse link
G Ncr3 natural cytotoxicity triggering receptor 3 multiple interactions ISO PD 0325901 inhibits the reaction [IL15 protein results in increased expression of NCR3 protein]; PD 0325901 inhibits the reaction [IL2 protein results in increased expression of NCR3 protein] CTD PMID:27563819 NCBI chr20:5,170,169...5,175,773
Ensembl chr20:5,170,215...5,175,773
JBrowse link
G Nf1 neurofibromin 1 multiple interactions ISO NF1 protein inhibits the reaction [SUZ12 gene mutant form results in increased susceptibility to [(+)-JQ1 compound co-treated with PD 0325901]] CTD PMID:25119042 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
JBrowse link
G Nme5 NME/NM23 family member 5 multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of NME5 mRNA CTD PMID:25119042 NCBI chr18:27,357,460...27,374,641
Ensembl chr18:27,357,413...27,374,603
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO PD 0325901 results in decreased expression of NR0B2 mRNA CTD PMID:24819614 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nrcam neuronal cell adhesion molecule decreases expression ISO PD 0325901 results in decreased expression of NRCAM mRNA CTD PMID:25119042 NCBI chr 6:64,297,843...64,867,408
Ensembl chr 6:64,297,888...64,864,996
JBrowse link
G Nrp1 neuropilin 1 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of NRP1 mRNA
PD 0325901 results in decreased expression of NRP1 mRNA
CTD PMID:25119042 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Ntm neurotrimin multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of NTM mRNA
PD 0325901 results in decreased expression of NTM mRNA
CTD PMID:25119042 NCBI chr 8:30,039,332...31,041,755
Ensembl chr 8:30,039,408...30,222,036
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [PD 0325901 co-treated with MK 2206] results in increased cleavage of PARP1 protein; [PD 0325901 co-treated with NVP-BKM120] results in increased cleavage of PARP1 protein; KRAS protein affects the susceptibility to [[PD 0325901 co-treated with NVP-BKM120] results in increased cleavage of PARP1 protein]; PD 0325901 promotes the reaction [Luteolin results in increased cleavage of PARP1 protein]; romidepsin promotes the reaction [[PD 0325901 co-treated with MK 2206] results in increased cleavage of PARP1 protein]; romidepsin promotes the reaction [PD 0325901 results in increased cleavage of PARP1 protein] CTD PMID:24576621, PMID:27634878, PMID:32268164 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO PD 0325901 inhibits the reaction [camostat results in increased expression of PCNA protein] CTD PMID:25104499 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of PDCD1LG2 mRNA CTD PMID:25119042 NCBI chr 1:247,562,202...247,629,279
Ensembl chr 1:247,562,202...247,627,193
JBrowse link
G Peg3 paternally expressed 3 decreases expression ISO PD 0325901 results in decreased expression of PEG3 mRNA CTD PMID:25119042 NCBI chr 1:70,210,810...70,237,450
Ensembl chr 1:70,222,964...70,237,443
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of PLAU mRNA
PD 0325901 results in decreased expression of PLAU mRNA
CTD PMID:25119042 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of PLAUR mRNA
PD 0325901 results in decreased expression of PLAUR mRNA
CTD PMID:25119042 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO PD 0325901 inhibits the reaction [Protein Kinase Inhibitors results in increased phosphorylation of and results in decreased activity of PPARG protein] CTD PMID:26670611 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prdm1 PR/SET domain 1 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of PRDM1 mRNA
[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of PRDM1 mRNA
CTD PMID:25119042 NCBI chr20:49,464,921...49,556,623
Ensembl chr20:49,464,919...49,556,518
JBrowse link
G Prrx1 paired related homeobox 1 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of PRRX1 mRNA
PD 0325901 results in decreased expression of PRRX1 mRNA
CTD PMID:25119042 NCBI chr13:81,147,038...81,215,559
Ensembl chr13:81,147,348...81,214,546
JBrowse link
G Ptx3 pentraxin 3 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of PTX3 mRNA
PD 0325901 results in decreased expression of PTX3 mRNA
CTD PMID:25119042 NCBI chr 2:158,097,843...158,103,653
Ensembl chr 2:158,097,843...158,103,653
JBrowse link
G Rac1 Rac family small GTPase 1 affects response to substance ISO RAC1 protein alternative form affects the susceptibility to PD 0325901 CTD PMID:23033341 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Reln reelin decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of RELN mRNA
[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of RELN mRNA
CTD PMID:25119042 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation
ISO 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one promotes the reaction [PD 0325901 results in decreased phosphorylation of RPS6 protein]; PD 0325901 promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of RPS6 protein]; PD 0325901 promotes the reaction [dactolisib results in decreased phosphorylation of RPS6 protein]; PD 0325901 promotes the reaction [NVP-BKM120 results in decreased phosphorylation of RPS6 protein] CTD PMID:22415236, PMID:24011934, PMID:24576621 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Scg5 secretogranin V multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of SCG5 mRNA CTD PMID:25119042 NCBI chr 3:105,235,065...105,279,475
Ensembl chr 3:105,235,050...105,279,462
JBrowse link
G Sema3a semaphorin 3A multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of SEMA3A mRNA
PD 0325901 results in decreased expression of SEMA3A mRNA
CTD PMID:25119042 NCBI chr 4:18,170,375...18,545,190
Ensembl chr 4:18,178,656...18,396,035
JBrowse link
G Siglec15 sialic acid binding Ig-like lectin 15 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of SIGLEC15 mRNA
PD 0325901 results in decreased expression of SIGLEC15 mRNA
CTD PMID:25119042 NCBI chr18:74,403,384...74,417,333
Ensembl chr18:74,403,384...74,417,333
JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of SLC6A15 mRNA
PD 0325901 results in decreased expression of SLC6A15 mRNA
CTD PMID:25119042 NCBI chr 7:45,328,207...45,381,920
Ensembl chr 7:45,328,105...45,382,229
JBrowse link
G Slit2 slit guidance ligand 2 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of SLIT2 mRNA
PD 0325901 results in decreased expression of SLIT2 mRNA
CTD PMID:25119042 NCBI chr14:66,831,848...67,171,491
Ensembl chr14:66,831,848...67,170,361
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression ISO PD 0325901 results in decreased expression of SOX9 mRNA CTD PMID:25119042 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of SPP1 mRNA CTD PMID:25119042 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of SPRY2 mRNA
PD 0325901 results in decreased expression of SPRY2 mRNA
CTD PMID:25119042 NCBI chr15:90,172,769...90,177,823
Ensembl chr15:90,172,975...90,175,802
JBrowse link
G St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ST3GAL6 mRNA
PD 0325901 results in decreased expression of ST3GAL6 mRNA
CTD PMID:25119042 NCBI chr11:44,176,518...44,237,119
Ensembl chr11:44,192,940...44,237,100
JBrowse link
G Stc1 stanniocalcin 1 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of STC1 mRNA
[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of STC1 mRNA
CTD PMID:25119042 NCBI chr15:50,891,137...50,901,791
Ensembl chr15:50,891,127...50,903,162
JBrowse link
G Stx1a syntaxin 1A multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of STX1A mRNA
PD 0325901 results in decreased expression of STX1A mRNA
CTD PMID:25119042 NCBI chr12:24,682,050...24,710,002
Ensembl chr12:24,682,041...24,710,019
JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit multiple interactions ISO NF1 protein inhibits the reaction [SUZ12 gene mutant form results in increased susceptibility to [(+)-JQ1 compound co-treated with PD 0325901]]; SUZ12 gene mutant form results in increased susceptibility to [(+)-JQ1 compound co-treated with PD 0325901] CTD PMID:25119042 NCBI chr10:67,325,101...67,371,588
Ensembl chr10:67,325,347...67,369,668
JBrowse link
G Syngap1 synaptic Ras GTPase activating protein 1 affects response to substance ISO SYNGAP1 protein affects the susceptibility to PD 0325901 CTD PMID:29940508 NCBI chr20:5,535,434...5,564,657
Ensembl chr20:5,535,432...5,564,437
JBrowse link
G Tbx3 T-box transcription factor 3 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of TBX3 mRNA
PD 0325901 results in decreased expression of TBX3 mRNA
CTD PMID:25119042 NCBI chr12:42,479,518...42,494,588
Ensembl chr12:42,480,560...42,492,526
JBrowse link
G Tfpi tissue factor pathway inhibitor multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of TFPI mRNA
PD 0325901 results in decreased expression of TFPI mRNA
CTD PMID:25119042 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of TGM2 mRNA
PD 0325901 results in decreased expression of TGM2 mRNA
CTD PMID:25119042 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of TLR4 mRNA
[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of TLR4 mRNA
CTD PMID:25119042 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tmem156 transmembrane protein 156 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of TMEM156 mRNA
PD 0325901 results in decreased expression of TMEM156 mRNA
CTD PMID:25119042 NCBI chr14:44,888,902...44,918,377
Ensembl chr14:44,889,287...44,918,373
JBrowse link
G Tnfsf15 TNF superfamily member 15 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of TNFSF15 mRNA
PD 0325901 results in decreased expression of TNFSF15 mRNA
CTD PMID:25119042 NCBI chr 5:79,553,935...79,569,974
Ensembl chr 5:79,553,742...79,570,073
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [PD 0325901 co-treated with MK 2206] results in increased expression of and results in increased phosphorylation of TRP53 protein CTD PMID:28691888 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib2 tribbles pseudokinase 2 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of TRIB2 mRNA
PD 0325901 results in decreased expression of TRIB2 mRNA
CTD PMID:25119042 NCBI chr 6:41,016,722...41,040,972
Ensembl chr 6:41,016,730...41,039,437
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions ISO PD 0325901 inhibits the reaction [Protein Kinase Inhibitors inhibits the reaction [FASN protein results in increased expression of UCP1 protein]] CTD PMID:26670611 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
G Ugt8 UDP glycosyltransferase 8 multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of UGT8 mRNA CTD PMID:25119042 NCBI chr 2:229,644,373...229,718,678
Ensembl chr 2:229,644,382...229,718,659
JBrowse link
G Vegfc vascular endothelial growth factor C multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of VEGFC mRNA
PD 0325901 results in decreased expression of VEGFC mRNA
CTD PMID:25119042 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ZEB1 mRNA CTD PMID:25119042 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antineoplastic agent 16985
              PD 0325901 128
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                hydroxamic acid 6264
                                                  hydroxamic acid ester 144
                                                    PD 0325901 128
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.