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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trans-rhaponticin
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Accession:CHEBI:8824 term browser browse the term
Definition:A rhaponticin in which the double bond adopts a trans-configuration. It possesses a range of pharmacological activities including antitumour, antiinflammatory, antilipemic and neuroprotective activities.
Synonyms:exact_synonym: 3-hydroxy-5-[(E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]phenyl beta-D-glucopyranoside
 related_synonym: (2S,3R,4S,5S,6R)-2-{3-hydroxy-5-[(E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]phenoxy}-6-(hydroxymethyl)oxane-3,4,5-triol;   (2S,3R,4S,5S,6R)-2-{3-hydroxy-5-[(E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]phenoxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;   (E)-rhaponticin;   Formula=C21H24O9;   InChI=1S/C21H24O9/c1-28-16-5-4-11(8-15(16)24)2-3-12-6-13(23)9-14(7-12)29-21-20(27)19(26)18(25)17(10-22)30-21/h2-9,17-27H,10H2,1H3/b3-2+/t17-,18-,19+,20-,21-/m1/s1;   InChIKey=GKAJCVFOJGXVIA-DXKBKAGUSA-N;   Rhapontin;   SMILES=COC1=CC=C(\\C=C\\C2=CC(O)=CC(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=C2)C=C1O;   ponticin;   rhaponticin;   rhaponticine
 xref: AGR:IND44126010;   CAS:155-58-8;   FooDB:FDB008525;   KEGG:C10288;   KNApSAcK:C00002904;   LIPID_MAPS_instance:LMPK13090002
 xref_mesh: MESH:C023538
 xref: PMID:19235684;   PMID:21782194;   PMID:22121779;   PMID:22452262;   PMID:23220535;   PMID:23364836;   PMID:23421127;   PMID:24362821;   PMID:25127020;   PMID:26598549;   PMID:27930969;   PMID:28364627;   PMID:30015877;   PMID:30666906;   PMID:31095470;   PMID:31108853;   PMID:32662907;   PMID:32926752;   PMID:33088192;   PMID:33494167;   PMID:33605003;   PMID:33770502;   PMID:7362262;   Wikipedia:Rhaponticin


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trans-rhaponticin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:32662907 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in decreased expression of HMOX1 mRNA]; rhapontin inhibits the reaction [Streptozocin results in decreased expression of HMOX1 protein] CTD PMID:32662907 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in decreased expression of IL10 mRNA]; rhapontin inhibits the reaction [Streptozocin results in decreased expression of IL10 protein] CTD PMID:32662907 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] CTD PMID:32662907 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in increased expression of KEAP1 mRNA]; rhapontin inhibits the reaction [Streptozocin results in increased expression of KEAP1 protein] CTD PMID:32662907 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in increased expression of MMP2 mRNA] CTD PMID:32662907 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA]; rhapontin inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein] CTD PMID:32662907 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in decreased expression of NQO1 mRNA] CTD PMID:32662907 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in decreased expression of TIMP1 mRNA] CTD PMID:32662907 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in increased expression of TNF mRNA] CTD PMID:32662907 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      application 19720
        anti-inflammatory agent 16695
          trans-rhaponticin 10
            6-O-malonyl-trans-rhaponticin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            heteroorganic entity 19540
                              organochalcogen compound 19301
                                organooxygen compound 19216
                                  carbohydrates and carbohydrate derivatives 15321
                                    carbohydrate 15321
                                      monosaccharide 4888
                                        aldose 3242
                                          aldohexose 2893
                                            glucose 2846
                                              D-glucose 2844
                                                D-glucopyranose 1818
                                                  beta-D-glucose 1665
                                                    beta-D-glucoside 1472
                                                      rhaponticin 10
                                                        trans-rhaponticin 10
                                                          6-O-malonyl-trans-rhaponticin 0
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