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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lead(II) chloride
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Accession:CHEBI:88212 term browser browse the term
Definition:An inorganic chloride consisting of two chlorine atoms covalently bound to a central lead atom.
Synonyms:exact_synonym: dichloro-lambda(2)-plumbane;   lead(2+) dichloride
 related_synonym: Formula=Cl2Pb;   InChI=1S/2ClH.Pb/h2*1H;/q;;+2/p-2;   InChIKey=HWSZZLVAJGOAAY-UHFFFAOYSA-L;   Lead dichloride;   Lead(2+) chloride;   PbCl2;   Plumbous chloride;   SMILES=[Pb](Cl)Cl;   lead chloride
 xref: CAS:7758-95-4
 xref_mesh: MESH:C029891
 xref: PMID:11345460;   Reaxys:3902843;   Reaxys:8128172;   Wikipedia:Lead(II)_chloride


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lead(II) chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of ACSL4 mRNA CTD PMID:18654764 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944
JBrowse link
G Actb actin, beta decreases expression ISO lead chloride results in decreased expression of ACTB protein CTD PMID:24419708 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Adk adenosine kinase multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of ADK mRNA CTD PMID:18654764 NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions
increases expression
ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1B10 mRNA
lead chloride results in increased expression of AKR1B10 mRNA
CTD PMID:18654764 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
increases expression
ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1C2 mRNA
lead chloride results in increased expression of AKR1C2 mRNA
CTD PMID:18654764 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Anxa1 annexin A1 increases expression ISO lead chloride results in increased expression of ANXA1 protein CTD PMID:24419708 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of ATF4 mRNA CTD PMID:18654764 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO lead chloride results in decreased expression of BCL2 protein CTD PMID:24419708 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of BHLHE40 mRNA CTD PMID:18654764 NCBI chr 4:140,703,619...140,709,319
Ensembl chr 4:140,703,619...140,709,319
JBrowse link
G Cald1 caldesmon 1 decreases expression ISO lead chloride results in decreased expression of CALD1 protein CTD PMID:24419708 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO lead chloride results in increased cleavage of CASP3 protein
[[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CASP3 protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of CASP3 protein
CTD PMID:24419708 PMID:32179164 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases cleavage ISO lead chloride results in increased cleavage of CASP9 protein CTD PMID:24419708 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CAT protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of CAT protein CTD PMID:32179164 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases secretion ISO lead chloride results in increased secretion of CCL5 protein CTD PMID:16099135 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccna1 cyclin A1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of CCNA1 mRNA CTD PMID:18654764 NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 decreases expression ISO lead chloride results in decreased expression of CCT2 protein CTD PMID:24419708 NCBI chr 7:60,106,532...60,122,779
Ensembl chr 7:60,109,974...60,122,805
JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 decreases expression ISO lead chloride results in decreased expression of CCT5 protein CTD PMID:24419708 NCBI chr 2:84,667,578...84,678,730
Ensembl chr 2:84,667,633...84,678,790
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of CREB1 mRNA CTD PMID:18654764 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO lead chloride results in increased expression of CYP1A1 mRNA CTD PMID:23503628 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 multiple interactions
increases expression
ISO [lead chloride affects the localization of NFE2L2 protein] promotes the reaction [NFE2L2 protein binds to CYP2A5 promoter]; NFE2L2 protein affects the reaction [lead chloride results in increased expression of CYP2A5 mRNA] CTD PMID:20402460 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 increases expression ISO lead chloride results in increased expression of DDAH2 protein CTD PMID:24419708 NCBI chr20:5,049,260...5,052,573
Ensembl chr20:5,049,496...5,052,585
JBrowse link
G Eea1 early endosome antigen 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of EEA1 mRNA CTD PMID:18654764 NCBI chr 7:37,101,415...37,186,534
Ensembl chr 7:37,018,459...37,186,732
JBrowse link
G Eef1b2 eukaryotic translation elongation factor 1 beta 2 increases expression ISO lead chloride results in increased expression of EEF1B2 protein CTD PMID:24419708 NCBI chr 9:69,953,440...69,956,158
Ensembl chr 9:69,953,440...69,956,160
JBrowse link
G Eef1d eukaryotic translation elongation factor 1 delta decreases expression ISO lead chloride results in decreased expression of EEF1D protein CTD PMID:24419708 NCBI chr 7:116,928,264...116,942,981
Ensembl chr 7:116,928,265...116,936,674
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO lead chloride results in increased phosphorylation of EIF2S1 protein CTD PMID:25410796 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of ELK1 mRNA CTD PMID:18654764 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Eno1 enolase 1 increases expression ISO lead chloride results in increased expression of ENO1 protein CTD PMID:24419708 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Erg28 ergosterol biosynthesis 28 homolog multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of ERG28 mRNA CTD PMID:18654764 NCBI chr 6:109,683,252...109,692,218
Ensembl chr 6:109,683,253...109,692,218
JBrowse link
G Esr1 estrogen receptor 1 affects response to substance
increases activity
decreases expression
multiple interactions
ISO ESR1 protein affects the susceptibility to lead chloride
lead chloride results in increased activity of ESR1 protein
lead chloride results in decreased expression of ESR1 mRNA; lead chloride results in decreased expression of ESR1 protein
Estradiol promotes the reaction [lead chloride results in decreased expression of ESR1 mRNA]; Estradiol promotes the reaction [lead chloride results in decreased expression of ESR1 protein]; lead chloride inhibits the reaction [Estradiol binds to ESR1 protein]; lead chloride promotes the reaction [Estradiol results in decreased expression of ESR1 protein]
CTD PMID:12746304 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Exoc5 exocyst complex component 5 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of EXOC5 mRNA CTD PMID:18654764 NCBI chr15:25,888,757...25,933,302
Ensembl chr15:25,887,070...25,933,268
JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of F2R mRNA CTD PMID:18654764 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta increases expression EXP lead chloride results in increased expression of GABRD mRNA CTD PMID:19651682 NCBI chr 5:172,797,478...172,809,374
Ensembl chr 5:172,797,450...172,809,353
JBrowse link
G Gas1 growth arrest-specific 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of GAS1 mRNA CTD PMID:18654764 NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
decreases expression
increases expression
ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GCLC mRNA
lead chloride results in decreased expression of GCLC protein
lead chloride results in increased expression of GCLC mRNA
CTD PMID:18654764 PMID:30359721 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression EXP lead chloride results in decreased expression of GFAP mRNA CTD PMID:19651682 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gm2a GM2 ganglioside activator multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GM2A mRNA CTD PMID:18654764 NCBI chr10:40,438,394...40,450,927
Ensembl chr10:40,438,356...40,450,930
JBrowse link
G Gna13 G protein subunit alpha 13 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GNA13 mRNA CTD PMID:18654764 NCBI chr10:97,647,196...97,680,030
Ensembl chr10:97,647,111...97,684,730
JBrowse link
G Gpnmb glycoprotein nmb multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GPNMB mRNA CTD PMID:18654764 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions
increases expression
ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GPX2 mRNA
lead chloride results in increased expression of GPX2 mRNA
CTD PMID:18654764 PMID:23503628 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 increases expression EXP lead chloride results in increased expression of GRIN1 mRNA CTD PMID:19651682 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression ISO lead chloride results in decreased expression of GSTM1 protein CTD PMID:30359721 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Heg1 heart development protein with EGF-like domains 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of HEG1 mRNA CTD PMID:18654764 NCBI chr11:70,234,248...70,322,966
Ensembl chr11:70,236,888...70,322,690
JBrowse link
G Hic1 HIC ZBTB transcriptional repressor 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of HIC1 mRNA CTD PMID:18654764 NCBI chr10:62,007,150...62,010,774
Ensembl chr10:62,007,150...62,009,582
JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity ISO
EXP
lead chloride results in decreased activity of HMBS protein
Lead Chloride decreases activity of purified Hmbs protein
CTD PMID:10416826, PMID:994723 RGD:25440497 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of HMGCR mRNA CTD PMID:18654764 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of HMGCS1 mRNA CTD PMID:18654764 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
increases expression
ISO lead chloride results in decreased expression of HMOX1 mRNA
lead chloride results in increased expression of HMOX1 mRNA
CTD PMID:20402460 PMID:23503628 PMID:23916686 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of HNRNPD mRNA CTD PMID:18654764 NCBI chr14:11,256,163...11,274,684
Ensembl chr14:11,256,268...11,274,578
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 affects localization
increases expression
decreases expression
EXP
ISO
lead chloride affects the localization of HSPA5 protein
lead chloride results in increased expression of HSPA5 protein
lead chloride results in decreased expression of HSPA5 protein
CTD PMID:19720107 PMID:21073006 PMID:24419708 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 decreases expression ISO lead chloride results in decreased expression of HSPA9 protein CTD PMID:24419708 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO lead chloride results in increased expression of HSPB1 protein CTD PMID:24419708 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression ISO lead chloride results in decreased expression of HSPD1 protein CTD PMID:24419708 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
ISO lead chloride results in decreased expression of IFNG protein
lead chloride results in decreased expression of IFNG mRNA
[lead chloride results in increased abundance of Lead] which results in increased expression of IFNG protein; decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of IFNG protein]; lead chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; lead chloride inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]
CTD PMID:8975779 PMID:15843504 PMID:23503628 PMID:30836164 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [lead chloride results in increased abundance of Lead] promotes the reaction [decabromobiphenyl ether results in increased expression of IL10 protein]; [lead chloride results in increased abundance of Lead] which results in increased expression of IL10 protein; decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of IL10 protein] CTD PMID:30836164 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of IL13RA2 mRNA CTD PMID:18654764 NCBI chr  X:118,443,955...118,514,716
Ensembl chr  X:118,443,823...118,513,061
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [lead chloride results in increased abundance of Lead] promotes the reaction [decabromobiphenyl ether results in increased expression of IL17A protein]; [lead chloride results in increased abundance of Lead] which results in increased expression of IL17A protein; decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of IL17A protein] CTD PMID:30836164 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO lead chloride results in decreased expression of IL1B protein
lead chloride results in decreased expression of IL1B mRNA
CTD PMID:15843504 PMID:23503628 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 decreases expression ISO lead chloride results in decreased expression of IL2 protein CTD PMID:15183152 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [lead chloride results in increased abundance of Lead] which results in increased expression of IL4 protein; decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of IL4 protein] CTD PMID:30836164 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [lead chloride results in increased abundance of Lead] which results in increased expression of IL6 protein; decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of IL6 protein] CTD PMID:30836164 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insig1 insulin induced gene 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of INSIG1 mRNA CTD PMID:18654764 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Kcns3 potassium voltage-gated channel, modifier subfamily S, member 3 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KCNS3 mRNA CTD PMID:18654764 NCBI chr 6:36,764,040...36,819,810
Ensembl chr 6:36,764,044...36,819,821
JBrowse link
G Klhl24 kelch-like family member 24 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KLHL24 mRNA CTD PMID:18654764 NCBI chr11:84,613,101...84,643,674
Ensembl chr11:84,615,760...84,633,504
JBrowse link
G Klhl7 kelch-like family member 7 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KLHL7 mRNA CTD PMID:18654764 NCBI chr 4:7,532,881...7,582,032
Ensembl chr 4:7,532,889...7,582,207
JBrowse link
G Lamp3 lysosomal-associated membrane protein 3 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of LAMP3 mRNA CTD PMID:18654764 NCBI chr11:84,930,965...85,000,694
Ensembl chr11:84,972,132...85,000,681
JBrowse link
G Lyz2 lysozyme 2 decreases expression ISO lead chloride results in decreased expression of LYZ protein CTD PMID:24419708 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of MAOA protein CTD PMID:32179164 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO lead chloride results in increased expression of MAPK8 protein modified form CTD PMID:24419708 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO lead chloride results in increased expression of MAPK9 protein modified form CTD PMID:24419708 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mcu mitochondrial calcium uniporter decreases expression EXP lead chloride results in decreased expression of MCU protein CTD PMID:24881885 NCBI chr20:29,037,452...29,199,224
Ensembl chr20:29,038,480...29,199,224
JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions
EXP
ISO
lead chloride results in increased expression of MT1A mRNA
[[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of MT1 protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of MT1 protein
lead chloride results in increased expression of MT1 mRNA
CTD PMID:19720107 PMID:23503628 PMID:32179164 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A increases expression ISO lead chloride results in increased expression of MT2 mRNA CTD PMID:23503628 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Myl6 myosin light chain 6 increases expression ISO lead chloride results in increased expression of MYL6 protein CTD PMID:24419708 NCBI chr 7:2,906,137...2,909,193
Ensembl chr 7:2,906,137...2,909,179
JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases expression EXP lead chloride results in decreased expression of NCAM1 mRNA; lead chloride results in decreased expression of NCAM1 protein; lead chloride results in decreased expression of NCAM1 protein modified form CTD PMID:18499259 NCBI chr 8:53,836,797...54,134,881
Ensembl chr 8:53,839,098...53,901,358
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase multiple interactions ISO [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of NEDD4 protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in decreased expression of NEDD4 protein CTD PMID:32179164 NCBI chr 8:79,323,408...79,408,842
Ensembl chr 8:79,323,408...79,408,833
JBrowse link
G Nefh neurofilament heavy chain increases expression EXP lead chloride results in increased expression of NEFH mRNA CTD PMID:19651682 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
decreases expression
affects localization
ISO [lead chloride affects the localization of NFE2L2 protein] promotes the reaction [NFE2L2 protein binds to CYP2A5 promoter]; NFE2L2 protein affects the reaction [lead chloride results in increased expression of CYP2A5 mRNA]
lead chloride results in decreased expression of NFE2L2 protein
CTD PMID:20402460 PMID:30359721 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos1 nitric oxide synthase 1 increases expression
decreases expression
EXP
ISO
lead chloride results in increased expression of NOS1 protein
lead chloride results in decreased expression of NOS1 mRNA; lead chloride results in decreased expression of NOS1 protein
CTD PMID:24881885 PMID:25410796 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
increases expression
multiple interactions
ISO lead chloride results in decreased expression of NOS2 mRNA
lead chloride results in decreased expression of NOS2 mRNA; lead chloride results in decreased expression of NOS2 protein
lead chloride results in increased expression of NOS2 mRNA
lead chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]
CTD PMID:8975779 PMID:23503628 PMID:23916686 PMID:25410796 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression ISO lead chloride results in decreased expression of NOS3 mRNA; lead chloride results in decreased expression of NOS3 protein CTD PMID:25410796 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox4 NADPH oxidase 4 increases expression ISO lead chloride results in increased expression of NOX4 protein CTD PMID:30359721 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Pde7a phosphodiesterase 7A multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of PDE7A mRNA CTD PMID:18654764 NCBI chr 2:104,042,124...104,134,101
Ensembl chr 2:104,045,811...104,134,101
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression ISO lead chloride results in decreased expression of PDIA3 protein CTD PMID:24419708 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression
ISO Estradiol promotes the reaction [lead chloride results in increased expression of PGR mRNA]; Estradiol promotes the reaction [lead chloride results in increased expression of PGR protein]; fulvestrant inhibits the reaction [lead chloride results in increased expression of PGR mRNA]; fulvestrant inhibits the reaction [lead chloride results in increased expression of PGR protein]; lead chloride promotes the reaction [Estradiol results in increased expression of PGR mRNA]; lead chloride promotes the reaction [Estradiol results in increased expression of PGR protein]
lead chloride results in increased expression of PGR mRNA; lead chloride results in increased expression of PGR protein
CTD PMID:12746304 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of PLA2G4A mRNA CTD PMID:18654764 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Plin3 perilipin 3 decreases expression ISO lead chloride results in decreased expression of PLIN3 protein CTD PMID:24419708 NCBI chr 9:10,769,739...10,781,659
Ensembl chr 9:10,773,901...10,781,109
JBrowse link
G Pou2f1 POU class 2 homeobox 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of POU2F1 mRNA CTD PMID:18654764 NCBI chr13:84,075,316...84,217,368
Ensembl chr13:84,083,632...84,217,366
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of PTGR1 mRNA CTD PMID:18654764 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Rgcc regulator of cell cycle multiple interactions
increases expression
ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of RGCC mRNA
lead chloride results in increased expression of RGCC mRNA
CTD PMID:18654764 NCBI chr15:61,551,861...61,564,695
Ensembl chr15:61,551,861...61,564,695
JBrowse link
G Rnase4 ribonuclease A family member 4 multiple interactions
increases expression
ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of RNASE4 mRNA
lead chloride results in increased expression of RNASE4 mRNA
CTD PMID:18654764 NCBI chr15:28,018,040...28,035,395
Ensembl chr15:28,018,040...28,035,389
Ensembl chr15:28,018,040...28,035,389
JBrowse link
G S100a11 S100 calcium binding protein A11 increases expression ISO lead chloride results in increased expression of S100A11 protein CTD PMID:24419708 NCBI chr 2:193,863,185...193,868,646
Ensembl chr 2:193,866,951...193,868,502
JBrowse link
G Scamp1 secretory carrier membrane protein 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of SCAMP1 mRNA CTD PMID:18654764 NCBI chr 2:23,858,021...23,941,128
Ensembl chr 2:23,857,995...23,941,084
JBrowse link
G Septin5 septin 5 multiple interactions ISO [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in decreased expression of SEPTIN5 protein CTD PMID:32179164 NCBI chr11:86,516,377...86,522,169
Ensembl chr11:86,512,797...86,522,168
JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases expression ISO lead chloride results in increased expression of SLC11A2 mRNA CTD PMID:23503628 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases activity
multiple interactions
ISO lead chloride results in increased activity of SLC22A8 protein
lead chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]
CTD PMID:28629854 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc6a6 solute carrier family 6 member 6 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of SLC6A6 mRNA CTD PMID:18654764 NCBI chr 4:123,638,619...123,713,469
Ensembl chr 4:123,642,210...123,713,464
JBrowse link
G Snrnp70 small nuclear ribonucleoprotein U1 subunit 70 multiple interactions ISO [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SNRNP70 protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of SNRNP70 protein CTD PMID:32179164 NCBI chr 1:101,367,470...101,388,153
Ensembl chr 1:101,367,471...101,388,129
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
increases expression
ISO lead chloride results in decreased expression of SOD1 mRNA
lead chloride results in increased expression of SOD1 mRNA
CTD PMID:23503628 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of SP1 protein CTD PMID:32179164 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sqle squalene epoxidase multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of SQLE mRNA CTD PMID:18654764 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Srf serum response factor multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of SRF mRNA CTD PMID:18654764 NCBI chr 9:16,737,637...16,747,226
Ensembl chr 9:16,737,642...16,747,225
JBrowse link
G Sry sex determining region Y multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of SRY mRNA CTD PMID:18654764 NCBI chr  Y:327,176...327,685
Ensembl chr  Y:327,166...329,299
JBrowse link
G St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 decreases expression EXP lead chloride results in decreased expression of ST8SIA2 mRNA CTD PMID:18499259 NCBI chr 1:135,336,374...135,406,699
Ensembl chr 1:135,336,374...135,406,700
JBrowse link
G St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 decreases expression EXP lead chloride results in decreased expression of ST8SIA4 mRNA CTD PMID:18499259 NCBI chr 9:103,117,705...103,207,154
Ensembl chr 9:103,117,506...103,207,190
JBrowse link
G Stk26 serine/threonine kinase 26 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of STK26 mRNA CTD PMID:18654764 NCBI chr  X:138,032,356...138,096,632
Ensembl chr  X:138,046,494...138,096,669
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO lead chloride results in decreased expression of TGFB1 mRNA CTD PMID:23503628 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tkt transketolase increases expression ISO lead chloride results in increased expression of TKT mRNA CTD PMID:18654764 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595
JBrowse link
G Tmem97 transmembrane protein 97 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of TMEM97 mRNA CTD PMID:18654764 NCBI chr10:65,811,455...65,820,538
Ensembl chr10:65,811,456...65,820,538
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO lead chloride results in decreased expression of TNF protein
lead chloride results in decreased expression of TNF mRNA
[lead chloride results in increased abundance of Lead] promotes the reaction [decabromobiphenyl ether results in increased expression of TNF protein]; [lead chloride results in increased abundance of Lead] which results in increased expression of TNF protein; decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of TNF protein]; lead chloride inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]
CTD PMID:8975779 PMID:15843504 PMID:23503628 PMID:30836164 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP [Hydrocarbons, Chlorinated co-treated with Cadmium Chloride co-treated with lead chloride] results in increased expression of TSHB protein CTD PMID:12011480 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Tspan7 tetraspanin 7 increases expression
multiple interactions
ISO lead chloride results in increased expression of TSPAN7 mRNA
[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of TSPAN7 mRNA
CTD PMID:18654764 NCBI chr  X:13,261,551...13,282,886
Ensembl chr  X:13,261,558...13,279,099
JBrowse link
G Tubb4b tubulin, beta 4B class IVb increases expression ISO lead chloride results in increased expression of TUBB4B protein CTD PMID:24419708 NCBI chr 3:2,441,585...2,444,369
Ensembl chr 3:2,441,733...2,444,281
JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression ISO lead chloride results in increased expression of TUBB protein CTD PMID:24419708 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of TYMS mRNA CTD PMID:18654764 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of UBA1 protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of UBA1 protein CTD PMID:32179164 NCBI chr  X:1,723,135...1,745,147
Ensembl chr  X:1,723,174...1,741,701
JBrowse link
G Uchl3 ubiquitin C-terminal hydrolase L3 multiple interactions ISO [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of UCHL3 protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of UCHL3 protein CTD PMID:32179164 NCBI chr15:86,153,624...86,198,127
Ensembl chr15:86,153,628...86,198,127
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of UGDH mRNA CTD PMID:18654764 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Vcp valosin-containing protein decreases expression ISO lead chloride results in decreased expression of VCP protein CTD PMID:24419708 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
G Vim vimentin decreases expression ISO lead chloride results in decreased expression of VIM protein CTD PMID:24419708 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Wnt4 Wnt family member 4 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of WNT4 mRNA CTD PMID:18654764 NCBI chr 5:155,649,238...155,668,065
Ensembl chr 5:155,649,217...155,672,579
JBrowse link
G Yy1 YY1 transcription factor multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of YY1 mRNA CTD PMID:18654764 NCBI chr 6:132,702,443...132,726,848
Ensembl chr 6:132,702,448...132,727,046
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    chemical entity 19773
      molecular entity 19771
        inorganic molecular entity 19453
          inorganic salt 11754
            inorganic chloride 8265
              lead(II) chloride 121
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      halogen 18108
                        chlorine atom 17927
                          chlorine molecular entity 17927
                            elemental chlorine 8444
                              monoatomic chlorine 8427
                                chloride 8427
                                  chloride salt 8427
                                    inorganic chloride 8265
                                      lead(II) chloride 121
paths to the root