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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lead(II) chloride
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Accession:CHEBI:88212 term browser browse the term
Definition:An inorganic chloride consisting of two chlorine atoms covalently bound to a central lead atom.
Synonyms:exact_synonym: dichloro-lambda(2)-plumbane;   lead(2+) dichloride
 related_synonym: Formula=Cl2Pb;   InChI=1S/2ClH.Pb/h2*1H;/q;;+2/p-2;   InChIKey=HWSZZLVAJGOAAY-UHFFFAOYSA-L;   Lead dichloride;   Lead(2+) chloride;   PbCl2;   Plumbous chloride;   SMILES=[Pb](Cl)Cl;   lead chloride
 xref: CAS:7758-95-4
 xref_mesh: MESH:C029891
 xref: PMID:11345460;   Reaxys:3902843;   Reaxys:8128172;   Wikipedia:Lead(II)_chloride



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lead(II) chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of ACSL4 mRNA CTD PMID:18654764 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427
JBrowse link
G Actb actin, beta decreases expression ISO lead chloride results in decreased expression of ACTB protein CTD PMID:24419708 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Adk adenosine kinase multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of ADK mRNA CTD PMID:18654764 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions
increases expression
ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1B10 mRNA
lead chloride results in increased expression of AKR1B10 mRNA
CTD PMID:18654764 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 multiple interactions
increases expression
ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1C1 mRNA
lead chloride results in increased expression of AKR1C1 mRNA
CTD PMID:18654764 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
increases expression
ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1C2 mRNA
lead chloride results in increased expression of AKR1C2 mRNA
CTD PMID:18654764 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Anxa1 annexin A1 increases expression ISO lead chloride results in increased expression of ANXA1 protein CTD PMID:24419708 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of ATF4 mRNA CTD PMID:18654764 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO lead chloride results in decreased expression of BCL2 protein CTD PMID:24419708 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of BHLHE40 mRNA CTD PMID:18654764 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
JBrowse link
G Cald1 caldesmon 1 decreases expression ISO lead chloride results in decreased expression of CALD1 protein CTD PMID:24419708 NCBI chr 4:63,265,781...63,446,936
Ensembl chr 4:63,265,942...63,446,932
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO lead chloride results in increased cleavage of CASP3 protein
[[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CASP3 protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of CASP3 protein
CTD PMID:24419708 PMID:32179164 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases cleavage ISO lead chloride results in increased cleavage of CASP9 protein CTD PMID:24419708 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CAT protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of CAT protein CTD PMID:32179164 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases secretion ISO lead chloride results in increased secretion of CCL5 protein CTD PMID:16099135 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccna1 cyclin A1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of CCNA1 mRNA CTD PMID:18654764 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 decreases expression ISO lead chloride results in decreased expression of CCT2 protein CTD PMID:24419708 NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944
JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 decreases expression ISO lead chloride results in decreased expression of CCT5 protein CTD PMID:24419708 NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of CREB1 mRNA CTD PMID:18654764 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO lead chloride results in increased expression of CYP1A1 mRNA CTD PMID:23503628 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 multiple interactions
increases expression
ISO [lead chloride affects the localization of NFE2L2 protein] promotes the reaction [NFE2L2 protein binds to CYP2A5 promoter]; NFE2L2 protein affects the reaction [lead chloride results in increased expression of CYP2A5 mRNA] CTD PMID:20402460 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 increases expression ISO lead chloride results in increased expression of DDAH2 protein CTD PMID:24419708 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511
JBrowse link
G Eea1 early endosome antigen 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of EEA1 mRNA CTD PMID:18654764 NCBI chr 7:30,554,686...30,722,186
Ensembl chr 7:30,554,552...30,718,487
JBrowse link
G Eef1b2 eukaryotic translation elongation factor 1 beta 2 increases expression ISO lead chloride results in increased expression of EEF1B2 protein CTD PMID:24419708 NCBI chr 9:64,580,009...64,582,737
Ensembl chr 9:64,579,893...64,582,737
JBrowse link
G Eef1d eukaryotic translation elongation factor 1 delta decreases expression ISO lead chloride results in decreased expression of EEF1D protein CTD PMID:24419708 NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO lead chloride results in increased phosphorylation of EIF2S1 protein CTD PMID:25410796 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of ELK1 mRNA CTD PMID:18654764 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Eno1 enolase 1 increases expression ISO lead chloride results in increased expression of ENO1 protein CTD PMID:24419708 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Erg28 ergosterol biosynthesis 28 homolog multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of ERG28 mRNA CTD PMID:18654764 NCBI chr 6:105,474,112...105,483,078
Ensembl chr 6:105,474,113...105,483,078
JBrowse link
G Esr1 estrogen receptor 1 affects response to substance
increases activity
decreases expression
multiple interactions
ISO ESR1 protein affects the susceptibility to lead chloride
lead chloride results in increased activity of ESR1 protein
lead chloride results in decreased expression of ESR1 mRNA; lead chloride results in decreased expression of ESR1 protein
Estradiol promotes the reaction [lead chloride results in decreased expression of ESR1 mRNA]; Estradiol promotes the reaction [lead chloride results in decreased expression of ESR1 protein]; lead chloride inhibits the reaction [Estradiol binds to ESR1 protein]; lead chloride promotes the reaction [Estradiol results in decreased expression of ESR1 protein]
CTD PMID:12746304 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Exoc5 exocyst complex component 5 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of EXOC5 mRNA CTD PMID:18654764 NCBI chr15:22,310,682...22,355,695
Ensembl chr15:22,308,946...22,355,335
JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of F2R mRNA CTD PMID:18654764 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta increases expression EXP lead chloride results in increased expression of GABRD mRNA CTD PMID:19651682 NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411
JBrowse link
G Gas1 growth arrest-specific 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of GAS1 mRNA CTD PMID:18654764 NCBI chr17:4,482,014...4,485,155 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
decreases expression
increases expression
ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GCLC mRNA
lead chloride results in decreased expression of GCLC protein
lead chloride results in increased expression of GCLC mRNA
CTD PMID:18654764 PMID:30359721 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression EXP lead chloride results in decreased expression of GFAP mRNA CTD PMID:19651682 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gm2a ganglioside GM2 activator multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GM2A mRNA CTD PMID:18654764 NCBI chr10:39,219,221...39,231,756
Ensembl chr10:39,219,243...39,231,757
JBrowse link
G Gna13 G protein subunit alpha 13 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GNA13 mRNA CTD PMID:18654764 NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774
JBrowse link
G Gpnmb glycoprotein nmb multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GPNMB mRNA CTD PMID:18654764 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions
increases expression
ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GPX2 mRNA
lead chloride results in increased expression of GPX2 mRNA
CTD PMID:18654764 PMID:23503628 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 increases expression EXP lead chloride results in increased expression of GRIN1 mRNA CTD PMID:19651682 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression ISO lead chloride results in decreased expression of GSTM1 protein CTD PMID:30359721 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Heg1 heart development protein with EGF-like domains 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of HEG1 mRNA CTD PMID:18654764 NCBI chr11:67,006,954...67,095,020
Ensembl chr11:66,957,190...67,095,051
JBrowse link
G Hic1 HIC ZBTB transcriptional repressor 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of HIC1 mRNA CTD PMID:18654764 NCBI chr10:60,014,520...60,019,475
Ensembl chr10:60,011,528...60,019,475
JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity ISO
EXP
lead chloride results in decreased activity of HMBS protein
Lead Chloride decreases activity of purified Hmbs protein
CTD
RGD
PMID:10416826 PMID:994723 RGD:25440497 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of HMGCR mRNA CTD PMID:18654764 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of HMGCS1 mRNA CTD PMID:18654764 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
increases expression
ISO lead chloride results in decreased expression of HMOX1 mRNA
lead chloride results in increased expression of HMOX1 mRNA
CTD PMID:20402460 PMID:23503628 PMID:23916686 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of HNRNPD mRNA CTD PMID:18654764 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 affects localization
increases expression
decreases expression
EXP
ISO
lead chloride affects the localization of HSPA5 protein
lead chloride results in increased expression of HSPA5 protein
lead chloride results in decreased expression of HSPA5 protein
CTD PMID:19720107 PMID:21073006 PMID:24419708 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 decreases expression ISO lead chloride results in decreased expression of HSPA9 protein CTD PMID:24419708 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO lead chloride results in increased expression of HSPB1 protein CTD PMID:24419708 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression ISO lead chloride results in decreased expression of HSPD1 protein CTD PMID:24419708 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
ISO lead chloride results in decreased expression of IFNG protein
lead chloride results in decreased expression of IFNG mRNA
[lead chloride results in increased abundance of Lead] which results in increased expression of IFNG protein; decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of IFNG protein]; lead chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; lead chloride inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]
CTD PMID:8975779 PMID:15843504 PMID:23503628 PMID:30836164 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [lead chloride results in increased abundance of Lead] promotes the reaction [decabromobiphenyl ether results in increased expression of IL10 protein]; [lead chloride results in increased abundance of Lead] which results in increased expression of IL10 protein; decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of IL10 protein] CTD PMID:30836164 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of IL13RA2 mRNA CTD PMID:18654764 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [lead chloride results in increased abundance of Lead] promotes the reaction [decabromobiphenyl ether results in increased expression of IL17A protein]; [lead chloride results in increased abundance of Lead] which results in increased expression of IL17A protein; decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of IL17A protein] CTD PMID:30836164 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO lead chloride results in decreased expression of IL1B protein
lead chloride results in decreased expression of IL1B mRNA
CTD PMID:15843504 PMID:23503628 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 decreases expression ISO lead chloride results in decreased expression of IL2 protein CTD PMID:15183152 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [lead chloride results in increased abundance of Lead] which results in increased expression of IL4 protein; decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of IL4 protein] CTD PMID:30836164 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [lead chloride results in increased abundance of Lead] which results in increased expression of IL6 protein; decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of IL6 protein] CTD PMID:30836164 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Insig1 insulin induced gene 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of INSIG1 mRNA CTD PMID:18654764 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Kcns3 potassium voltage-gated channel, modifier subfamily S, member 3 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KCNS3 mRNA CTD PMID:18654764 NCBI chr 6:33,808,314...33,865,018
Ensembl chr 6:33,808,216...33,865,125
JBrowse link
G Klhl24 kelch-like family member 24 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KLHL24 mRNA CTD PMID:18654764 NCBI chr11:80,843,621...80,877,693
Ensembl chr11:80,846,755...80,877,636
JBrowse link
G Klhl7 kelch-like family member 7 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KLHL7 mRNA CTD PMID:18654764 NCBI chr 4:11,006,366...11,055,399
Ensembl chr 4:11,006,375...11,055,541
JBrowse link
G Lamp3 lysosomal-associated membrane protein 3 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of LAMP3 mRNA CTD PMID:18654764 NCBI chr11:81,153,491...81,224,643
Ensembl chr11:81,193,649...81,221,784
JBrowse link
G Lyz2 lysozyme 2 decreases expression ISO lead chloride results in decreased expression of LYZ protein CTD PMID:24419708 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of MAOA protein CTD PMID:32179164 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO lead chloride results in increased expression of MAPK8 protein modified form CTD PMID:24419708 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO lead chloride results in increased expression of MAPK9 protein modified form CTD PMID:24419708 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mcu mitochondrial calcium uniporter decreases expression EXP lead chloride results in decreased expression of MCU protein CTD PMID:24881885 NCBI chr20:27,417,529...27,580,110
Ensembl chr20:27,417,526...27,580,110
JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions
EXP
ISO
lead chloride results in increased expression of MT1A mRNA
[[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of MT1 protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of MT1 protein
lead chloride results in increased expression of MT1 mRNA
CTD PMID:19720107 PMID:23503628 PMID:32179164 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
JBrowse link
G Mt2A metallothionein 2A increases expression ISO lead chloride results in increased expression of MT2 mRNA CTD PMID:23503628 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Myl6 myosin light chain 6 increases expression ISO lead chloride results in increased expression of MYL6 protein CTD PMID:24419708 NCBI chr 7:910,764...914,062
Ensembl chr 7:910,774...933,791
JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases expression EXP lead chloride results in decreased expression of NCAM1 mRNA; lead chloride results in decreased expression of NCAM1 protein; lead chloride results in decreased expression of NCAM1 protein modified form CTD PMID:18499259 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase multiple interactions ISO [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of NEDD4 protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in decreased expression of NEDD4 protein CTD PMID:32179164 NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951
JBrowse link
G Nefh neurofilament heavy chain increases expression EXP lead chloride results in increased expression of NEFH mRNA CTD PMID:19651682 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression
affects localization
ISO [lead chloride affects the localization of NFE2L2 protein] promotes the reaction [NFE2L2 protein binds to CYP2A5 promoter]; NFE2L2 protein affects the reaction [lead chloride results in increased expression of CYP2A5 mRNA]
lead chloride results in decreased expression of NFE2L2 protein
CTD PMID:20402460 PMID:30359721 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos1 nitric oxide synthase 1 increases expression
decreases expression
EXP
ISO
lead chloride results in increased expression of NOS1 protein
lead chloride results in decreased expression of NOS1 mRNA; lead chloride results in decreased expression of NOS1 protein
CTD PMID:24881885 PMID:25410796 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
increases expression
multiple interactions
ISO lead chloride results in decreased expression of NOS2 mRNA
lead chloride results in decreased expression of NOS2 mRNA; lead chloride results in decreased expression of NOS2 protein
lead chloride results in increased expression of NOS2 mRNA
lead chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]
CTD PMID:8975779 PMID:23503628 PMID:23916686 PMID:25410796 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression ISO lead chloride results in decreased expression of NOS3 mRNA; lead chloride results in decreased expression of NOS3 protein CTD PMID:25410796 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nox4 NADPH oxidase 4 increases expression ISO lead chloride results in increased expression of NOX4 protein CTD PMID:30359721 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Pde7a phosphodiesterase 7A multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of PDE7A mRNA CTD PMID:18654764 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression ISO lead chloride results in decreased expression of PDIA3 protein CTD PMID:24419708 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression
ISO Estradiol promotes the reaction [lead chloride results in increased expression of PGR mRNA]; Estradiol promotes the reaction [lead chloride results in increased expression of PGR protein]; fulvestrant inhibits the reaction [lead chloride results in increased expression of PGR mRNA]; fulvestrant inhibits the reaction [lead chloride results in increased expression of PGR protein]; lead chloride promotes the reaction [Estradiol results in increased expression of PGR mRNA]; lead chloride promotes the reaction [Estradiol results in increased expression of PGR protein]
lead chloride results in increased expression of PGR mRNA; lead chloride results in increased expression of PGR protein
CTD PMID:12746304 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of PLA2G4A mRNA CTD PMID:18654764 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Plin3 perilipin 3 decreases expression ISO lead chloride results in decreased expression of PLIN3 protein CTD PMID:24419708 NCBI chr 9:1,111,178...1,123,117
Ensembl chr 9:1,102,366...1,123,147
JBrowse link
G Pou2f1 POU class 2 homeobox 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of POU2F1 mRNA CTD PMID:18654764 NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of PTGR1 mRNA CTD PMID:18654764 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
G Rgcc regulator of cell cycle multiple interactions
increases expression
ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of RGCC mRNA
lead chloride results in increased expression of RGCC mRNA
CTD PMID:18654764 NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141
JBrowse link
G Rnase4 ribonuclease A family member 4 multiple interactions
increases expression
ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of RNASE4 mRNA
lead chloride results in increased expression of RNASE4 mRNA
CTD PMID:18654764 NCBI chr15:24,312,765...24,330,116
Ensembl chr15:24,312,464...24,330,117
JBrowse link
G S100a11 S100 calcium binding protein A11 increases expression ISO lead chloride results in increased expression of S100A11 protein CTD PMID:24419708 NCBI chr 2:179,191,504...179,197,098
Ensembl chr 2:179,191,715...179,197,044
JBrowse link
G Scamp1 secretory carrier membrane protein 1 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of SCAMP1 mRNA CTD PMID:18654764 NCBI chr 2:25,433,958...25,516,734
Ensembl chr 2:25,433,959...25,516,673
JBrowse link
G Septin5 septin 5 multiple interactions ISO [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in decreased expression of SEPTIN5 protein CTD PMID:32179164 NCBI chr11:82,373,601...82,379,393
Ensembl chr11:82,369,754...82,379,393
JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases expression ISO lead chloride results in increased expression of SLC11A2 mRNA CTD PMID:23503628 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases activity
multiple interactions
ISO lead chloride results in increased activity of SLC22A8 protein
lead chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]
CTD PMID:28629854 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc6a6 solute carrier family 6 member 6 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of SLC6A6 mRNA CTD PMID:18654764 NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
JBrowse link
G Snrnp70 small nuclear ribonucleoprotein U1 subunit 70 multiple interactions ISO [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SNRNP70 protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of SNRNP70 protein CTD PMID:32179164 NCBI chr 1:95,856,039...95,876,434
Ensembl chr 1:95,856,036...95,876,392
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
increases expression
ISO lead chloride results in decreased expression of SOD1 mRNA
lead chloride results in increased expression of SOD1 mRNA
CTD PMID:23503628 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of SP1 protein CTD PMID:32179164 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sqle squalene epoxidase multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of SQLE mRNA CTD PMID:18654764 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Srf serum response factor multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of SRF mRNA CTD PMID:18654764 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733
JBrowse link
G Sry sex determining region Y multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of SRY mRNA CTD PMID:18654764
G St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 decreases expression EXP lead chloride results in decreased expression of ST8SIA2 mRNA CTD PMID:18499259 NCBI chr 1:127,766,669...127,838,017
Ensembl chr 1:127,762,573...127,838,091
JBrowse link
G St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 decreases expression EXP lead chloride results in decreased expression of ST8SIA4 mRNA CTD PMID:18499259 NCBI chr 9:95,994,150...96,084,617
Ensembl chr 9:95,993,503...96,084,653
JBrowse link
G Stk26 serine/threonine kinase 26 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of STK26 mRNA CTD PMID:18654764 NCBI chr  X:130,310,855...130,375,677
Ensembl chr  X:130,310,885...130,374,291
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO lead chloride results in decreased expression of TGFB1 mRNA CTD PMID:23503628 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tkt transketolase increases expression ISO lead chloride results in increased expression of TKT mRNA CTD PMID:18654764 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
G Tmem97 transmembrane protein 97 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of TMEM97 mRNA CTD PMID:18654764 NCBI chr10:63,438,228...63,447,311
Ensembl chr10:63,438,222...63,589,730
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO lead chloride results in decreased expression of TNF protein
lead chloride results in decreased expression of TNF mRNA
[lead chloride results in increased abundance of Lead] promotes the reaction [decabromobiphenyl ether results in increased expression of TNF protein]; [lead chloride results in increased abundance of Lead] which results in increased expression of TNF protein; decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of TNF protein]; lead chloride inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]
CTD PMID:8975779 PMID:15843504 PMID:23503628 PMID:30836164 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP [Hydrocarbons, Chlorinated co-treated with Cadmium Chloride co-treated with lead chloride] results in increased expression of TSHB protein CTD PMID:12011480 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Tspan7 tetraspanin 7 increases expression
multiple interactions
ISO lead chloride results in increased expression of TSPAN7 mRNA
[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of TSPAN7 mRNA
CTD PMID:18654764 NCBI chr  X:12,208,783...12,306,160
Ensembl chr  X:12,208,783...12,306,131
JBrowse link
G Tubb4b tubulin, beta 4B class IVb increases expression ISO lead chloride results in increased expression of TUBB4B protein CTD PMID:24419708 NCBI chr 3:8,037,844...8,040,294
Ensembl chr 3:8,037,799...8,040,296
JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression ISO lead chloride results in increased expression of TUBB protein CTD PMID:24419708 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of TYMS mRNA CTD PMID:18654764 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of UBA1 protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of UBA1 protein CTD PMID:32179164 NCBI chr  X:1,508,700...1,530,677
Ensembl chr  X:1,508,666...1,530,636
JBrowse link
G Uchl3 ubiquitin C-terminal hydrolase L3 multiple interactions ISO [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of UCHL3 protein; [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of UCHL3 protein CTD PMID:32179164 NCBI chr15:78,485,304...78,527,355
Ensembl chr15:78,485,315...78,527,355
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of UGDH mRNA CTD PMID:18654764 NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354
JBrowse link
G Vcp valosin-containing protein decreases expression ISO lead chloride results in decreased expression of VCP protein CTD PMID:24419708 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
JBrowse link
G Vim vimentin decreases expression ISO lead chloride results in decreased expression of VIM protein CTD PMID:24419708 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wnt4 Wnt family member 4 multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of WNT4 mRNA CTD PMID:18654764 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859
JBrowse link
G Yy1 YY1 transcription factor multiple interactions ISO [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of YY1 mRNA CTD PMID:18654764 NCBI chr 6:127,706,739...127,731,907
Ensembl chr 6:127,707,596...127,732,747
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      molecular entity 20054
        inorganic molecular entity 19769
          inorganic salt 12697
            inorganic chloride 8273
              lead(II) chloride 122
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      halogen 18511
                        chlorine atom 18305
                          chlorine molecular entity 18305
                            elemental chlorine 8462
                              monoatomic chlorine 8445
                                chloride 8445
                                  chloride salt 8445
                                    inorganic chloride 8273
                                      lead(II) chloride 122
paths to the root