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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:drug allergen
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Accession:CHEBI:88188 term browser browse the term
Definition:Any drug which causes the onset of an allergic reaction.
Synonyms:related_synonym: allergenic drug


show annotations for term's descendants           Sort by:
acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Aspirin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
cortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRH corticotropin releasing hormone increases abundance EXP CRH protein results in increased abundance of Hydrocortisone CTD PMID:2831029 NCBI chr29:15,831,944...15,840,560
Ensembl chr29:15,831,944...15,834,384 		JBrowse link
G INS insulin affects abundance
multiple interactions		 EXP INS protein affects the abundance of Hydrocortisone
Sodium affects the reaction [INS protein affects the abundance of Hydrocortisone]		 CTD PMID:1324617 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
G POMC proopiomelanocortin increases abundance EXP POMC protein results in increased abundance of Hydrocortisone CTD PMID:2831029 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440 		JBrowse link
cyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 2B11 increases hydroxylation EXP CYP2B6 protein results in increased hydroxylation of Cyclophosphamide CTD PMID:16546968 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293 		JBrowse link
desipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2D15 cytochrome P450 family 2 subfamily D member 15 affects metabolic processing EXP CYP2D15 affects the metabolism of Desipramine CTD PMID:7786018 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298 		JBrowse link
diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C18 cytochrome P450 2C21 increases hydroxylation EXP CYP2C19 protein results in increased hydroxylation of Diclofenac CTD PMID:15677349 NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587 		JBrowse link
G CYP2C41 cytochrome P450 2C41 affects metabolic processing EXP CYP2C9 protein affects the metabolism of Diclofenac CTD PMID:15801540
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Diclofenac results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
ibuprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Ibuprofen results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP Ibuprofen results in increased expression of PTGS2 protein CTD PMID:16105799 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903 		JBrowse link
phenobarbital term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAA1 acetyl-CoA acyltransferase 1 decreases expression EXP Phenobarbital results in decreased expression of ACAA1 mRNA CTD PMID:19952500 NCBI chr23:7,889,481...7,901,324
Ensembl chr23:7,889,500...7,901,229 		JBrowse link
G ACAA2 acetyl-CoA acyltransferase 2 decreases expression EXP Phenobarbital results in decreased expression of ACAA2 mRNA CTD PMID:19952500 NCBI chr 7:79,028,636...79,057,720 JBrowse link
G ACOX2 acyl-CoA oxidase 2 decreases expression EXP Phenobarbital results in decreased expression of ACOX2 mRNA CTD PMID:19952500 NCBI chr20:32,110,788...32,141,751
Ensembl chr20:32,113,217...32,141,734 		JBrowse link
G AGXT alanine--glyoxylate and serine--pyruvate aminotransferase decreases expression EXP Phenobarbital results in decreased expression of AGXT protein CTD PMID:19952500 NCBI chr25:50,968,291...50,976,089 JBrowse link
G AHCY adenosylhomocysteinase decreases expression EXP Phenobarbital results in decreased expression of AHCY protein CTD PMID:19952500 NCBI chr24:23,410,553...23,423,494
Ensembl chr24:23,411,140...23,419,767 		JBrowse link
G ASL argininosuccinate lyase decreases expression EXP Phenobarbital results in decreased expression of ASL protein CTD PMID:19952500 NCBI chr 6:768,522...779,144
Ensembl chr 6:730,358...779,424 		JBrowse link
G ASS1 argininosuccinate synthase 1 decreases expression EXP Phenobarbital results in decreased expression of ASS1 protein CTD PMID:19952500 NCBI chr 9:53,425,228...53,478,007
Ensembl chr 9:53,425,448...53,477,904 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase decreases expression EXP Phenobarbital results in decreased expression of BHMT protein CTD PMID:19952500 NCBI chr 3:27,732,381...27,752,168
Ensembl chr 3:27,734,108...27,752,046 		JBrowse link
G CA3 carbonic anhydrase 3 decreases expression EXP Phenobarbital results in decreased expression of CA3 protein CTD PMID:19952500 NCBI chr29:31,935,192...31,945,585
Ensembl chr29:31,935,172...31,980,579 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A decreases expression EXP Phenobarbital results in decreased expression of CPT1A mRNA CTD PMID:19952500 NCBI chr18:49,136,691...49,190,117
Ensembl chr18:49,136,691...49,190,117 		JBrowse link
G CRYZ crystallin zeta increases expression EXP Phenobarbital results in increased expression of CRYZ protein CTD PMID:19952500 NCBI chr 6:71,656,162...71,693,020
Ensembl chr 6:71,656,188...71,675,692 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases expression EXP Phenobarbital results in decreased expression of CYP1A2 mRNA CTD PMID:19952500 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135 		JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A polypeptide 13 decreases expression EXP Phenobarbital results in decreased expression of CYP2A13 mRNA CTD PMID:19952500 NCBI chr 1:112,932,246...112,938,248
Ensembl chr 1:112,931,985...112,938,350 		JBrowse link
G CYP2B6 cytochrome P450 2B11 increases expression EXP Phenobarbital results in increased expression of CYP2B6 protein CTD PMID:19952500 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases expression EXP Phenobarbital results in decreased expression of CYP2E1 mRNA CTD PMID:19952500 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754 		JBrowse link
G CYP3A12 cytochrome P-450 3A12 increases expression EXP Phenobarbital results in increased expression of CYP3A12 protein CTD PMID:19952500
G CYP3A26 cytochrome P450 3A26 increases expression EXP Phenobarbital results in increased expression of CYP3A26 mRNA CTD PMID:19952500 NCBI chr 6:9,777,663...9,815,345
Ensembl chr 6:9,777,659...9,869,352 		JBrowse link
G CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 increases expression EXP Phenobarbital results in increased expression of CYP3A4 mRNA CTD PMID:19952500 NCBI chr 6:9,836,685...9,869,520
Ensembl chr 6:9,777,659...9,869,352 		JBrowse link
G CYP4A37 cytochrome P450 4A37 decreases expression EXP Phenobarbital results in decreased expression of CYP4A11 mRNA CTD PMID:19952500 NCBI chr15:13,604,130...13,623,797 JBrowse link
G EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase decreases expression EXP Phenobarbital results in decreased expression of EHHADH mRNA CTD PMID:19952500 NCBI chr34:18,021,047...18,080,993
Ensembl chr34:18,022,353...18,080,903 		JBrowse link
G FTCD formimidoyltransferase cyclodeaminase increases expression EXP Phenobarbital results in increased expression of FTCD protein CTD PMID:19952500 NCBI chr31:39,451,557...39,464,249
Ensembl chr31:39,275,159...39,464,715 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 decreases expression EXP Phenobarbital results in decreased expression of GOT1 protein CTD PMID:19952500 NCBI chr28:12,352,658...12,377,960
Ensembl chr28:12,352,659...12,414,579 		JBrowse link
G GSTA4 glutathione S-transferase alpha 4 decreases expression EXP Phenobarbital results in decreased expression of GSTA4 mRNA CTD PMID:19952500 NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 increases expression EXP Phenobarbital results in increased expression of GSTO1 mRNA CTD PMID:19952500 NCBI chr28:16,569,421...16,579,239
Ensembl chr28:16,569,066...16,619,880 		JBrowse link
G GSTT2B glutathione S-transferase theta 2B decreases expression EXP Phenobarbital results in decreased expression of GSTT2 mRNA CTD PMID:19952500 NCBI chr26:28,573,435...28,580,846 JBrowse link
G HADH hydroxyacyl-CoA dehydrogenase decreases expression EXP Phenobarbital results in decreased expression of HADH mRNA CTD PMID:19952500 NCBI chr32:28,460,445...28,506,141
Ensembl chr32:28,460,193...28,531,280 		JBrowse link
G HPD 4-hydroxyphenylpyruvate dioxygenase decreases expression EXP Phenobarbital results in decreased expression of HPD protein CTD PMID:19952500 NCBI chr26:7,430,891...7,440,643
Ensembl chr26:7,430,933...7,440,611 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Phenobarbital results in increased expression of HSPA5 protein CTD PMID:19952500 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257 		JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 decreases expression EXP Phenobarbital results in decreased expression of IDH1 protein CTD PMID:19952500 NCBI chr37:16,512,027...16,531,269
Ensembl chr37:16,512,770...16,531,219 		JBrowse link
G LOC474938 glutathione S-transferase A2 increases expression EXP Phenobarbital results in increased expression of GSTA3 protein CTD PMID:19952500 NCBI chr12:20,349,133...20,365,023 JBrowse link
G LOC477540 SEC14-like protein 3 decreases expression EXP Phenobarbital results in decreased expression of SEC14L3 protein CTD PMID:19952500 NCBI chr26:23,580,899...23,590,676
Ensembl chr26:23,580,901...23,590,622 		JBrowse link
G LOC486353 SEC14-like protein 4 decreases expression EXP Phenobarbital results in decreased expression of SEC14L4 protein CTD PMID:19952500 NCBI chr26:23,598,434...23,611,727
Ensembl chr26:23,600,237...23,618,123 		JBrowse link
G MGST1 microsomal glutathione S-transferase 1 increases expression EXP Phenobarbital results in increased expression of MGST1 mRNA CTD PMID:19952500 NCBI chr27:30,370,588...30,391,898
Ensembl chr27:30,370,594...30,391,778 		JBrowse link
G MGST2 microsomal glutathione S-transferase 2 increases expression EXP Phenobarbital results in increased expression of MGST2 mRNA CTD PMID:19952500 NCBI chr19:3,067,062...3,070,579 JBrowse link
G MGST3 microsomal glutathione S-transferase 3 decreases expression EXP Phenobarbital results in decreased expression of MGST3 mRNA CTD PMID:19952500 NCBI chr38:17,670,329...17,691,822
Ensembl chr38:17,668,752...17,718,704 		JBrowse link
G PAH phenylalanine hydroxylase decreases expression EXP Phenobarbital results in decreased expression of PAH protein CTD PMID:19952500 NCBI chr15:41,590,253...41,670,156
Ensembl chr15:41,592,876...41,670,837 		JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 increases expression EXP Phenobarbital results in increased expression of PDIA3 protein CTD PMID:19952500 NCBI chr30:10,487,926...10,513,437
Ensembl chr30:10,487,921...10,513,397 		JBrowse link
G PRDX6 peroxiredoxin 6 decreases expression EXP Phenobarbital results in decreased expression of PRDX6 protein CTD PMID:19952500 NCBI chr 7:25,663,238...25,675,855
Ensembl chr 7:25,663,579...25,675,754 		JBrowse link
G SELENBP1 selenium binding protein 1 decreases expression EXP Phenobarbital results in decreased expression of SELENBP1 protein CTD PMID:19952500 NCBI chr17:60,410,727...60,418,770
Ensembl chr17:60,410,734...60,418,704 		JBrowse link
G SOD1 superoxide dismutase 1 affects response to substance EXP SOD1 protein affects the susceptibility to Phenobarbital CTD PMID:6333936 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815 		JBrowse link
G UGDH UDP-glucose 6-dehydrogenase increases expression EXP Phenobarbital results in increased expression of UGDH protein CTD PMID:19952500 NCBI chr 3:72,935,532...72,964,151
Ensembl chr 3:72,839,920...72,963,208 		JBrowse link
G UGT2B31 UDP-glucuronosyltransferase UGT2B31 increases expression EXP Phenobarbital results in increased expression of UGT2B4 protein CTD PMID:19952500 NCBI chr13:58,993,957...59,007,420 JBrowse link
G UROC1 urocanate hydratase 1 decreases expression EXP Phenobarbital results in decreased expression of UROC1 protein CTD PMID:19952500 NCBI chr20:676,624...717,109
Ensembl chr20:678,073...717,141 		JBrowse link
salicylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444 		JBrowse link
succinylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase increases hydrolysis
multiple interactions		 EXP BCHE protein results in increased hydrolysis of Succinylcholine
Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]		 CTD PMID:4985882 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 494
    role 501
      biological role 494
        aetiopathogenetic role 392
          allergen 64
            drug allergen 50
              (4R)-limonene hydroperoxide + 0
              3,3',4',5-tetrachlorosalicylanilide 0
              4',5-dihydroxydiclofenac 0
              4-hydroperoxycyclophosphamide 0
              5,5-diethylbarbituric acid 0
              D-penicillamine + 0
              abacavir + 0
              acetylsalicylic acid + 1
              alclofenac 0
              alcuronium bromide 0
              amodiaquine + 0
              aztreonam + 0
              benzo[d]isothiazol-3-one 0
              benzoic acid + 2
              benzylpenicillin + 0
              budesonide 0
              bupivacaine 0
              calcipotriol + 0
              carbamazepine + 0
              carbapenem MM22383 0
              cefaclor 0
              cefixime 0
              cefotaxime 0
              ceftazidime + 0
              ceftriaxone 0
              cefuroxime 0
              cephalosporin + 0
              chlorambucil 0
              co-trimoxazole 0
              codeine + 0
              cortisol + 3
              cortisol 17-butyrate 0
              cyclophosphamide + 1
              desipramine + 1
              desipramine hydrochloride 0
              diaveridine 0
              diclofenac + 2
              diphenylcyclopropenone 0
              disodium cromoglycate 0
              eslicarbazepine acetate 0
              fenoprofen 0
              fenticlor 0
              fluoxetine 0
              gallamine 0
              ibuprofen + 2
              isoniazide + 0
              ketoprofen 0
              licarbazepine + 0
              lidocaine + 0
              melphalan 0
              mepivacaine + 0
              meropenem + 0
              methohexital 0
              metiazinic acid 0
              morphine + 0
              naproxen + 0
              oxcarbazepine 0
              oxybuprocaine + 0
              parthenolide + 0
              phenobarbital + 41
              phenytoin 0
              pholcodine 0
              piroctone olamine 0
              procaine 0
              quinidine + 0
              ranitidine + 0
              ranitidine hydrochloride 0
              rocuronium + 0
              sodium benzoate + 0
              succinylcholine + 1
              sulfachloropyridazine 0
              sulfadiazine 0
              sulfadimethoxine 0
              sulfamerazine 0
              sulfamethazine + 0
              sulfamethizole 0
              sulfamethoxazole + 0
              sulfamethoxypyridazine 0
              sulfamoxole 0
              sulfanilamide + 0
              sulfapyridine 0
              sulfasalazine 0
              sulfathiazole + 0
              sulfisoxazole + 0
              suprofen 0
              thimerosal 0
              thiopental 0
              tiaprofenic acid 0
              triclosan 0
              trimethoprim + 0
              tubocurarine 0
              vecuronium + 0
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