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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:resiniferatoxin
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Accession:CHEBI:8809 term browser browse the term
Definition:A heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1).
Synonyms:exact_synonym: [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-benzyl-6a-hydroxy-8,10-dimethyl-7-oxo-11a-(prop-1-en-2-yl)-3a,6,6a,7,9a,10,11,11a-octahydro-3bH-2,9b-epoxyazuleno[4',5':5,6]benzo[1,2-d][1,3]dioxol-5-yl]methyl (4-hydroxy-3-methoxyphenyl)acetate
 related_synonym: Formula=C37H40O9;   InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35-,36-,37-/m1/s1;   InChIKey=DSDNAKHZNJAGHN-MXTYGGKSSA-N;   RTX;   SMILES=C=1(C=C(C(=CC1)O)OC)CC(OCC2=C[C@@]3([C@]4([C@]5([C@](C2)(C(=O)C(=C5)C)O)[H])O[C@]6(O[C@@]([C@@]3(O6)[H])(C(=C)C)C[C@H]4C)CC=7C=CC=CC7)[H])=O
 xref: CAS:57444-62-9;   DrugBank:DB06515;   KEGG:C09179;   KNApSAcK:C00003478
 xref_mesh: MESH:C024353
 xref: PDBeChem:6EU;   PMID:26779292;   PMID:27281200;   PMID:2747924;   PMID:27529257;   PMID:29041773;   PMID:29271803;   PMID:29320813;   PMID:29361418;   PMID:29672450;   PMID:29728656;   PMID:30015705;   PMID:30399572;   PMID:30590777;   PMID:31090543;   PMID:31124075;   PMID:31180583;   PMID:31503071;   PMID:31811858;   PMID:32064609;   PMID:32292906;   PMID:7189445;   Reaxys:5371150;   Wikipedia:Resiniferatoxin


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resiniferatoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha multiple interactions
decreases expression
ISO 4-methylcatechol inhibits the reaction [resiniferatoxin results in decreased expression of CALCA protein]; resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of CALCA protein] CTD PMID:17291600 PMID:18219259 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO
resiniferatoxin inhibits the reaction [anandamide results in increased expression of FOS protein]; resiniferatoxin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein]
resiniferatoxin promotes the reaction [Bee Venoms results in increased expression of FOS protein]
CTD PMID:15217452 PMID:15601931 PMID:16621078 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Ifng interferon gamma multiple interactions ISO resiniferatoxin inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; resiniferatoxin inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; resiniferatoxin inhibits the reaction [IFNG results in increased activity of STAT1 protein]; resiniferatoxin inhibits the reaction [IFNG results in increased expression of NOS2 protein] CTD PMID:14530214 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 increases expression EXP resiniferatoxin results in increased expression of IL10 mRNA; resiniferatoxin results in increased expression of IL10 protein CTD PMID:18460982 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO resiniferatoxin promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:17291600 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein] CTD PMID:14530214 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein] CTD PMID:14530214 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO resiniferatoxin results in increased activity of MAPK8 protein CTD PMID:9580328 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases activity ISO resiniferatoxin results in increased activity of MAPK9 protein CTD PMID:9580328 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO resiniferatoxin inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; resiniferatoxin inhibits the reaction [[Lipopolysaccharides results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; resiniferatoxin inhibits the reaction [IFNG results in increased expression of NOS2 protein]; resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:14530214 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Sst somatostatin multiple interactions ISO resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of SST protein] CTD PMID:17291600 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO resiniferatoxin inhibits the reaction [IFNG results in increased activity of STAT1 protein] CTD PMID:14530214 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions
decreases expression
ISO resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of TAC1 protein]
resiniferatoxin results in decreased expression of TAC1 protein
CTD PMID:17291600 PMID:18219259 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tnf tumor necrosis factor decreases expression EXP resiniferatoxin results in decreased expression of TNF mRNA CTD PMID:18460982 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions
increases expression
ISO capsazepine inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein]; phenyl-N-tert-butylnitrone inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein]; TRPV1 gene mutant form inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein] CTD PMID:19531269 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 decreases expression EXP resiniferatoxin results in decreased expression of TRPA1 mRNA CTD PMID:25077949 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
decreases expression
increases activity
affects binding
ISO
EXP
[resiniferatoxin binds to and results in increased activity of TRPV1 protein] which results in increased abundance of Calcium; [resiniferatoxin binds to TRPV1 protein] which results in increased uptake of Calcium; Cannabidiol inhibits the reaction [[resiniferatoxin binds to TRPV1 protein] which results in increased uptake of Calcium]; Cannabidiol inhibits the reaction [resiniferatoxin binds to TRPV1 protein]; resiniferatoxin binds to and results in increased activity of TRPV1 protein
resiniferatoxin results in decreased expression of TRPV1 mRNA
resiniferatoxin results in increased activity of TRPV1 protein
capsazepine inhibits the reaction [resiniferatoxin promotes the reaction [TRPV1 protein binds to TRPV1 protein]]; Cyclosporine affects the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Docosahexaenoic Acids inhibits the reaction [resiniferatoxin binds to and results in increased activity of TRPV1 protein]; Eicosapentaenoic Acid inhibits the reaction [resiniferatoxin binds to and results in increased activity of TRPV1 protein]; Ionomycin inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; JYL 1421 inhibits the reaction [resiniferatoxin binds to TRPV1 protein]; KJM 429 inhibits the reaction [resiniferatoxin binds to TRPV1 protein]; N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]; resiniferatoxin binds to and results in increased activity of TRPV1 protein; resiniferatoxin promotes the reaction [Calcium Chloride results in increased activity of TRPV1 protein]; resiniferatoxin promotes the reaction [TRPV1 protein binds to TRPV1 protein]; Tacrolimus affects the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Tetradecanoylphorbol Acetate affects the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [resiniferatoxin binds to TRPV1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [resiniferatoxin inhibits the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester promotes the reaction [resiniferatoxin promotes the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Calcium Chloride inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Ionomycin promotes the reaction [Calcium Chloride inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]]; resiniferatoxin inhibits the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]; resiniferatoxin promotes the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]; TRPV1 gene mutant form inhibits the reaction [resiniferatoxin results in increased abundance of Reactive Oxygen Species]; TRPV1 gene mutant form inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein]
CTD PMID:11358970 PMID:11606325 PMID:12237342 PMID:15363968 PMID:16597917 PMID:17038422 PMID:19531269 PMID:19553475 PMID:21908651 PMID:25077949 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions
decreases expression
ISO 4-methylcatechol inhibits the reaction [resiniferatoxin results in decreased expression of UCHL1 protein] CTD PMID:18219259 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973
JBrowse link

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  CHEBI ontology 19786
    role 19732
      biological role 19732
        pharmacological role 18842
          analgesic 13304
            resiniferatoxin 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic group 18631
                              organic divalent group 18622
                                organodiyl group 18622
                                  carbonyl group 18537
                                    carbonyl compound 18537
                                      ketone 16871
                                        oxyketone 8660
                                          alpha-oxyketone 8660
                                            alpha-hydroxy ketone 8660
                                              tertiary alpha-hydroxy ketone 8380
                                                resiniferatoxin 18
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