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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Repaglinide
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Accession:CHEBI:8805 term browser browse the term
Definition:A piperidine that has formula C27H36N2O4.
Synonyms:related_synonym: (S)-(+)-Repaglinide;   Formula=C27H36N2O4;   InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1;   InChIKey=FAEKWTJYAYMJKF-QHCPKHFHSA-N;   SMILES=CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(O)=O;   enyglid;   surepost
 xref: CAS:135062-02-1;   Drug_Central:2366;   HMDB:HMDB0015048;   KEGG:C07670;   KEGG:D00594;   LINCS:LSM-3863
 xref_mesh: MESH:C072379


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Repaglinide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO repaglinide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
repaglinide results in decreased activity of ABCB11 protein
CTD PMID:23956101 PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO repaglinide affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 affects expression ISO repaglinide affects the expression of HLA-F mRNA CTD PMID:25811541 NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991
JBrowse link
G Slc15a1 solute carrier family 15 member 1 decreases activity ISO repaglinide results in decreased activity of SLC15A1 protein CTD PMID:15846457 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO repaglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO repaglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    chemical entity 19761
      atom 19759
        nonmetal atom 19641
          nitrogen atom 18572
            nitrogen molecular entity 18572
              organonitrogen compound 18361
                organonitrogen heterocyclic compound 17521
                  piperidines 7565
                    Repaglinide 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic molecule 19493
                              organic cyclic compound 19318
                                organic heterocyclic compound 18510
                                  organic heteromonocyclic compound 16986
                                    piperidines 7565
                                      Repaglinide 6
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