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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Repaglinide
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Accession:CHEBI:8805 term browser browse the term
Definition:A piperidine that has formula C27H36N2O4.
Synonyms:related_synonym: (S)-(+)-Repaglinide;   Formula=C27H36N2O4;   InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1;   InChIKey=FAEKWTJYAYMJKF-QHCPKHFHSA-N;   SMILES=CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(O)=O;   enyglid;   surepost
 xref: CAS:135062-02-1;   Drug_Central:2366;   HMDB:HMDB0015048;   KEGG:C07670;   KEGG:D00594;   LINCS:LSM-3863
 xref_mesh: MESH:C072379


show annotations for term's descendants           Sort by:
Repaglinide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions
decreases activity		 ISO repaglinide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
repaglinide results in decreased activity of ABCB11 protein		 CTD PMID:23956101 PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO repaglinide inhibits the reaction [Rotenone results in increased expression of ATF6 protein] CTD PMID:36538285 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340 		JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions ISO repaglinide inhibits the reaction [Rotenone results in decreased expression of BECN1 protein] CTD PMID:36538285 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO repaglinide inhibits the reaction [Rotenone results in increased activity of CASP3 protein] CTD PMID:36538285 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase multiple interactions ISO repaglinide inhibits the reaction [Rotenone results in decreased activity of CAT protein] CTD PMID:36538285 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 decreases expression ISO repaglinide metabolite results in decreased expression of CXCL8 mRNA CTD PMID:26528891 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO repaglinide inhibits the reaction [Rotenone results in increased expression of DDIT3 mRNA] CTD PMID:36538285 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Gck glucokinase increases expression
multiple interactions		 ISO repaglinide analog results in increased expression of GCK mRNA
repaglinide analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GCK mRNA]; repaglinide inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GCK mRNA]		 CTD PMID:35702883 NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO repaglinide inhibits the reaction [Rotenone results in increased expression of GFAP protein] CTD PMID:36538285 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO repaglinide analog affects the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GLUD1 mRNA]; repaglinide inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GLUD1 mRNA] CTD PMID:35702883 NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222 		JBrowse link
G Gm7030 predicted gene 7030 affects expression ISO repaglinide affects the expression of HLA-F mRNA CTD PMID:25811541 NCBI chr17:36,438,501...36,440,317
Ensembl chr17:36,420,611...36,440,317 		JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO repaglinide inhibits the reaction [Rotenone results in increased expression of HSPA5 protein] CTD PMID:36538285 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO repaglinide inhibits the reaction [Rotenone results in increased expression of IL1B protein] CTD PMID:36538285 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO repaglinide inhibits the reaction [Rotenone results in increased expression of IL6 protein] CTD PMID:36538285 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I multiple interactions ISO repaglinide analog affects the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein]; repaglinide inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein] CTD PMID:35702883 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Kcnip3 Kv channel interacting protein 3, calsenilin multiple interactions ISO repaglinide inhibits the reaction [Rotenone results in decreased expression of KCNIP3 mRNA] CTD PMID:36538285 NCBI chr 2:127,298,418...127,364,014
Ensembl chr 2:127,298,418...127,364,014 		JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO repaglinide affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr 1:155,003,620...155,022,560
Ensembl chr 1:155,003,023...155,022,560 		JBrowse link
G Pink1 PTEN induced putative kinase 1 multiple interactions ISO repaglinide inhibits the reaction [Rotenone results in decreased expression of PINK1 mRNA] CTD PMID:36538285 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618 		JBrowse link
G Slc15a1 solute carrier family 15 (oligopeptide transporter), member 1 decreases activity ISO repaglinide results in decreased activity of SLC15A1 protein CTD PMID:15846457 NCBI chr14:121,697,033...121,742,666
Ensembl chr14:121,697,033...121,742,664 		JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 multiple interactions ISO repaglinide analog affects the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A2 mRNA]; repaglinide inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A2 mRNA] CTD PMID:35702883 NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions ISO repaglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO repaglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      atom 22170
        nonmetal atom 22055
          nitrogen atom 20030
            nitrogen molecular entity 20004
              organonitrogen compound 19809
                organonitrogen heterocyclic compound 19099
                  piperidines 7828
                    Repaglinide 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                organic heterocyclic compound 20352
                                  organic heteromonocyclic compound 18733
                                    piperidines 7828
                                      Repaglinide 22
paths to the root