Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Repaglinide
go back to main search page
Accession:CHEBI:8805 term browser browse the term
Definition:A piperidine that has formula C27H36N2O4.
Synonyms:related_synonym: (S)-(+)-Repaglinide;   Formula=C27H36N2O4;   InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1;   InChIKey=FAEKWTJYAYMJKF-QHCPKHFHSA-N;   SMILES=CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(O)=O;   enyglid;   surepost
 xref: CAS:135062-02-1;   Drug_Central:2366;   HMDB:HMDB0015048;   KEGG:C07670;   KEGG:D00594;   LINCS:LSM-3863
 xref_mesh: MESH:C072379

show annotations for term's descendants           Sort by:
 
Repaglinide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO repaglinide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
repaglinide results in decreased activity of ABCB11 protein		 CTD PMID:23956101 PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO repaglinide affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841 		JBrowse link
G RT1-CE5 RT1 class I, locus CE5 affects expression ISO repaglinide affects the expression of HLA-F mRNA CTD PMID:25811541 NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 decreases activity ISO repaglinide results in decreased activity of SLC15A1 protein CTD PMID:15846457 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO repaglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO repaglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    chemical entity 19883
      atom 19881
        nonmetal atom 19760
          nitrogen atom 18646
            nitrogen molecular entity 18646
              organonitrogen compound 18422
                organonitrogen heterocyclic compound 17582
                  piperidines 7569
                    Repaglinide 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic molecule 19596
                              organic cyclic compound 19407
                                organic heterocyclic compound 18517
                                  organic heteromonocyclic compound 16622
                                    piperidines 7569
                                      Repaglinide 6
paths to the root