CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Repaglinide
Accession: CHEBI:8805
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Definition: A piperidine that has formula C27H36N2O4.
Synonyms: related_synonym: (S)-(+)-Repaglinide; Formula=C27H36N2O4; InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1; InChIKey=FAEKWTJYAYMJKF-QHCPKHFHSA-N; SMILES=CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(O)=O; enyglid; surepost
xref: CAS:135062-02-1; Drug_Central:2366; HMDB:HMDB0015048; KEGG:C07670; KEGG:D00594; LINCS:LSM-3863
xref_mesh: MESH:C072379
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Abcb11
ATP binding cassette subfamily B member 11
multiple interactions decreases activity
ISO
repaglinide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] repaglinide results in decreased activity of ABCB11 protein
CTD
PMID:23956101 PMID:24014644
NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
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Mr1
major histocompatibility complex, class I-related
affects expression
ISO
repaglinide affects the expression of MR1 mRNA
CTD
PMID:25811541
NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
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RT1-CE5
RT1 class I, locus CE5
affects expression
ISO
repaglinide affects the expression of HLA-F mRNA
CTD
PMID:25811541
NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991
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Slc15a1
solute carrier family 15 member 1
decreases activity
ISO
repaglinide results in decreased activity of SLC15A1 protein
CTD
PMID:15846457
NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
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Slco1b2
solute carrier organic anion transporter family member 1B2
multiple interactions
ISO
repaglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]
CTD
PMID:23121773
NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
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Slco2b1
solute carrier organic anion transporter family, member 2b1
multiple interactions
ISO
repaglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]
CTD
PMID:23121773
NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
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