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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:8802 term browser browse the term
Definition:A piperidinecarboxylate ester that is methyl piperidine-4-carboxylate in which the hydrogen attached to the nitrogen is substituted by a 3-methoxy-3-oxopropyl group and the hydrogen at position 4 is substituted the nitrogen of N-propanoylaniline.
Synonyms:exact_synonym: methyl 1-(3-methoxy-3-oxopropyl)-4-[phenyl(propanoyl)amino]piperidine-4-carboxylate
 related_synonym: Formula=C20H28N2O5;   InChI=1S/C20H28N2O5/c1-4-17(23)22(16-8-6-5-7-9-16)20(19(25)27-3)11-14-21(15-12-20)13-10-18(24)26-2/h5-9H,4,10-15H2,1-3H3;   InChIKey=ZTVQQQVZCWLTDF-UHFFFAOYSA-N;   SMILES=CCC(=O)N(c1ccccc1)C1(CCN(CCC(=O)OC)CC1)C(=O)OC
 alt_id: CHEBI:211871
 xref: CAS:132875-61-7;   DrugBank:DB00899;   Drug_Central:2363;   HMDB:HMDB0015036;   KEGG:C08021;   KEGG:D08473
 xref_mesh: MESH:C071741
 xref: Patent:EP383579;   Patent:US5019583;   Reaxys:4358750;   Wikipedia:Remifentanil

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remifentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
increases phosphorylation
EXP Ketamine inhibits the reaction [remifentanil results in increased phosphorylation of GRIN2B protein] CTD PMID:20042082 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO remifentanil affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions
affects localization
EXP Lidocaine inhibits the reaction [remifentanil affects the localization of PRKCG protein] CTD PMID:19955894 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          analgesic 13063
            opioid analgesic 630
              remifentanil 3
                remifentanil hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        amine 7602
                                          primary amine 5664
                                            primary arylamine 2955
                                              aniline 2803
                                                anilide 265
                                                  remifentanil 3
                                                    remifentanil hydrochloride 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.