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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4,6-dioxoheptanoic acid
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Accession:CHEBI:87897 term browser browse the term
Definition:A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.
Synonyms:related_synonym: Formula=C7H10O4;   InChI=1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11);   InChIKey=WYEPBHZLDUPIOD-UHFFFAOYSA-N;   SMILES=CC(CC(CCC(O)=O)=O)=O;   succinylacetone
 alt_id: CHEBI:45625
 xref: CAS:51568-18-4;   HMDB:HMDB0000635
 xref_mesh: MESH:C020804
 xref: PDBeChem:SHU;   PMID:10073910;   PMID:12052898;   PMID:16414314;   PMID:16448836;   PMID:17133337;   PMID:20351174;   PMID:22455637;   PMID:22456946;   PMID:22521492;   PMID:22906829;   PMID:25066104;   PMID:2889780;   Patent:US2011201539;   Reaxys:2436097


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4,6-dioxoheptanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas1 5'-aminolevulinate synthase 1 multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [succinylacetone results in increased expression of ALAS1 mRNA]
succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]
CTD PMID:21659532, PMID:22859313 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression
multiple interactions
ISO succinylacetone results in increased expression of CYP2A5 mRNA
NFE2L2 gene mutant form affects the reaction [succinylacetone results in increased expression of CYP2A5 mRNA]
CTD PMID:22859313 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO succinylacetone results in increased expression of HMOX1 mRNA CTD PMID:22859313 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 gene mutant form affects the reaction [succinylacetone results in increased expression of CYP2A5 mRNA]; NFE2L2 gene mutant form inhibits the reaction [succinylacetone results in increased expression of ALAS1 mRNA] CTD PMID:22859313 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO succinylacetone results in increased expression of PPARGC1A mRNA CTD PMID:22859313 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link

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  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            eukaryotic metabolite 18943
              animal metabolite 18747
                mammalian metabolite 18746
                  human metabolite 18254
                    4,6-dioxoheptanoic acid 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        monocarboxylic acid 17476
                                          oxo monocarboxylic acid 6267
                                            dioxo monocarboxylic acid 1916
                                              4,6-dioxoheptanoic acid 5
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