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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4,6-dioxoheptanoic acid
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Accession:CHEBI:87897 term browser browse the term
Definition:A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.
Synonyms:related_synonym: Formula=C7H10O4;   InChI=1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11);   InChIKey=WYEPBHZLDUPIOD-UHFFFAOYSA-N;   SMILES=CC(CC(CCC(O)=O)=O)=O;   succinylacetone
 alt_id: CHEBI:45625
 xref: CAS:51568-18-4;   HMDB:HMDB0000635
 xref_mesh: MESH:C020804
 xref: PDBeChem:SHU;   PMID:10073910;   PMID:12052898;   PMID:16414314;   PMID:16448836;   PMID:17133337;   PMID:20351174;   PMID:22455637;   PMID:22456946;   PMID:22521492;   PMID:22906829;   PMID:25066104;   PMID:2889780;   Patent:US2011201539;   Reaxys:2436097



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4,6-dioxoheptanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas1 5'-aminolevulinate synthase 1 multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [succinylacetone results in increased expression of ALAS1 mRNA]
succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]
CTD PMID:21659532 PMID:22859313 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression
multiple interactions
ISO succinylacetone results in increased expression of CYP2A5 mRNA
NFE2L2 gene mutant form affects the reaction [succinylacetone results in increased expression of CYP2A5 mRNA]
CTD PMID:22859313 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO succinylacetone results in increased expression of HMOX1 mRNA CTD PMID:22859313 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 gene mutant form affects the reaction [succinylacetone results in increased expression of CYP2A5 mRNA]; NFE2L2 gene mutant form inhibits the reaction [succinylacetone results in increased expression of ALAS1 mRNA] CTD PMID:22859313 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO succinylacetone results in increased expression of PPARGC1A mRNA CTD PMID:22859313 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link

Term paths to the root
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  CHEBI ontology 19800
    role 19751
      biological role 19751
        biochemical role 19368
          metabolite 19344
            eukaryotic metabolite 19033
              animal metabolite 18895
                mammalian metabolite 18895
                  human metabolite 18398
                    4,6-dioxoheptanoic acid 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        monocarboxylic acid 17622
                                          oxo monocarboxylic acid 6277
                                            dioxo monocarboxylic acid 1910
                                              4,6-dioxoheptanoic acid 5
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