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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4,6-dioxoheptanoic acid
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Accession:CHEBI:87897 term browser browse the term
Definition:A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.
Synonyms:related_synonym: Formula=C7H10O4;   InChI=1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11);   InChIKey=WYEPBHZLDUPIOD-UHFFFAOYSA-N;   SMILES=CC(CC(CCC(O)=O)=O)=O;   succinylacetone
 alt_id: CHEBI:45625
 xref: CAS:51568-18-4;   HMDB:HMDB0000635
 xref_mesh: MESH:C020804
 xref: PDBeChem:SHU;   PMID:10073910;   PMID:12052898;   PMID:16414314;   PMID:16448836;   PMID:17133337;   PMID:20351174;   PMID:22455637;   PMID:22456946;   PMID:22521492;   PMID:22906829;   PMID:25066104;   PMID:2889780;   Patent:US2011201539;   Reaxys:2436097


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4,6-dioxoheptanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas1 5'-aminolevulinate synthase 1 multiple interactions
increases expression		 ISO NFE2L2 gene mutant form inhibits the reaction [succinylacetone results in increased expression of ALAS1 mRNA]
succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]		 CTD PMID:21659532 PMID:22859313 NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO succinylacetone results in increased expression of HMOX1 mRNA CTD PMID:22859313 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 gene mutant form affects the reaction [succinylacetone results in increased expression of CYP2A5 mRNA]; NFE2L2 gene mutant form inhibits the reaction [succinylacetone results in increased expression of ALAS1 mRNA] CTD PMID:22859313 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO succinylacetone results in increased expression of PPARGC1A mRNA CTD PMID:22859313 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        biochemical role 19496
          metabolite 19484
            eukaryotic metabolite 19303
              animal metabolite 19168
                mammalian metabolite 19193
                  human metabolite 18704
                    4,6-dioxoheptanoic acid 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      monocarboxylic acid 17952
                                        oxo monocarboxylic acid 6292
                                          dioxo monocarboxylic acid 1911
                                            4,6-dioxoheptanoic acid 4
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