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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ramipril
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Accession:CHEBI:8774 term browser browse the term
Definition:A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.
Synonyms:exact_synonym: (2S,3aS,6aS)-1-[(2S)-2-{[(1S)-1-ethoxycarbonyl-3-phenylpropyl]amino}propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
 related_synonym: (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid;   Altace (TN);   Formula=C23H32N2O5;   InChI=1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1;   InChIKey=HDACQVRGBOVJII-JBDAPHQKSA-N;   Ramiprilum;   SMILES=CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1[C@H]2CCC[C@H]2C[C@H]1C(O)=O;   Tritace
 xref: Beilstein:4214464;   CAS:87333-19-5;   DrugBank:DB00178;   Drug_Central:2356;   HMDB:HMDB0014324;   KEGG:D00421;   LINCS:LSM-5950
 xref_mesh: MESH:D017257
 xref: PMID:11095026;   PMID:11575208;   PMID:12076194;   PMID:12768220;   PMID:15110900;   PMID:16144510;   PMID:16734081;   PMID:17004100;   PMID:17192135;   PMID:17496463;   PMID:17903031;   PMID:20122169;   PMID:22799880;   PMID:23557551;   PMID:23713675;   PMID:23747952;   PMID:23842688;   PMID:23842829;   PMID:23951921;   PMID:24048485;   PMID:24090393;   PMID:24191305;   PMID:24397981;   PMID:24435506;   PMID:24452090;   PMID:24509355;   Reaxys:4214464;   VSDB:1888;   Wikipedia:Ramipril


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ramipril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity ISO Ramipril results in decreased activity of ACE protein CTD PMID:3034026 PMID:10543928 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
decreases expression
ISO candesartan promotes the reaction [Ramipril results in increased expression of ADIPOQ]; Ramipril promotes the reaction [candesartan results in increased expression of ADIPOQ]
Ramipril results in decreased expression of ADIPOQ
CTD PMID:17483542 PMID:19059660 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression EXP Ramipril affects the expression of BAX protein CTD PMID:10728395 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression EXP Ramipril affects the expression of BCL2 protein CTD PMID:10728395 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions EXP Ramipril inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein] CTD PMID:17703430 NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Simvastatin co-treated with Ramipril] results in decreased expression of CCL2 protein CTD PMID:15184351 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased expression of CCN2 protein CTD PMID:31062909 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis ISO CES1 protein results in increased hydrolysis of Ramipril CTD PMID:25445008 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Ramipril results in decreased expression of COL1A1 mRNA CTD PMID:11851355 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression
ISO Ramipril inhibits the reaction [Cyclosporine results in increased expression of CYBA mRNA]; Ramipril inhibits the reaction [Tacrolimus results in increased expression of CYBA mRNA]
Ramipril results in decreased expression of CYBA mRNA
CTD PMID:12352326 PMID:16891913 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression ISO Ramipril results in decreased expression of CYBB mRNA CTD PMID:16891913 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased phosphorylation of FOXO3 protein CTD PMID:31062909 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Kng2 kininogen 2 decreases degradation EXP Ramipril results in decreased degradation of KNG1 protein CTD PMID:2535056 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lep leptin multiple interactions
decreases expression
ISO candesartan promotes the reaction [Ramipril results in increased expression of LEP]; Ramipril promotes the reaction [candesartan results in increased expression of LEP]
Ramipril results in decreased expression of LEP
CTD PMID:17483542 PMID:19059660 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; Ramipril inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein] CTD PMID:31062909 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP Ramipril results in decreased expression of MMP2 mRNA CTD PMID:11851355 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Myh7 myosin heavy chain 7 decreases expression EXP Ramipril results in decreased expression of MYH7 mRNA CTD PMID:15667801 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP [Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein; Metoprolol inhibits the reaction [[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein]; Metoprolol inhibits the reaction [Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA]]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA] CTD PMID:11832429 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO NOS3 protein affects the reaction [Ramipril results in increased abundance of Cyclic GMP] CTD PMID:16891913 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppb natriuretic peptide B decreases expression EXP Ramipril results in decreased expression of NPPB mRNA CTD PMID:15667801 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions
decreases expression
ISO Ramipril inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PDGFA mRNA]
Ramipril results in decreased expression of PDGFA mRNA
CTD PMID:10352363 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions
decreases expression
ISO Ramipril inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PDGFB mRNA]
Ramipril results in decreased expression of PDGFB mRNA
CTD PMID:10352363 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of PTGS2 protein; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of PTGS2 mRNA] CTD PMID:11832429 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ren renin increases activity
increases expression
multiple interactions
ISO
EXP
Ramipril results in increased activity of REN protein
Ramipril results in increased expression of REN protein
Ramipril inhibits the reaction [Isoproterenol results in increased expression of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased activity of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]
Ramipril results in increased expression of REN mRNA
CTD PMID:1327051 PMID:9179393 PMID:9539862 PMID:11832429 PMID:14504926 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP [Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased expression of RHOA protein]; Ramipril inhibits the reaction [Streptozocin results in increased expression of RHOA protein] CTD PMID:31062909 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions EXP [Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased expression of ROCK2 protein]; Ramipril inhibits the reaction [Streptozocin results in increased expression of ROCK2 protein] CTD PMID:31062909 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased expression of SIRT1 protein CTD PMID:31062909 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Ramipril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP Ramipril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:66,932,664...66,961,708
Ensembl chr11:66,932,614...66,961,713
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased phosphorylation of SMAD2 protein CTD PMID:31062909 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
decreases activity
ISO
EXP
Ramipril inhibits the reaction [Cyclosporine results in increased expression of TGFB1 mRNA]; Ramipril inhibits the reaction [Tacrolimus results in increased expression of TGFB1 mRNA]
Ramipril results in decreased expression of TGFB1 mRNA
[Streptozocin co-treated with Ramipril] results in increased expression of TGFB1 protein; [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased expression of TGFB1 protein; Ramipril inhibits the reaction [Tacrolimus results in increased expression of TGFB1 protein]
Ramipril results in decreased activity of TGFB1 protein
CTD PMID:12352326 PMID:12631109 PMID:15667801 PMID:17703430 PMID:20551625 PMID:31062909 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 multiple interactions EXP [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased expression of TGFBR3 protein CTD PMID:31062909 NCBI chr14:3,506,416...3,680,508
Ensembl chr14:3,506,339...3,682,545
JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 increases expression EXP Ramipril results in increased expression of TIMP4 mRNA CTD PMID:11851355 NCBI chr 4:147,156,948...147,163,467
Ensembl chr 4:147,156,948...147,163,467
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      application 19423
        pro-agent 10100
          prodrug 9905
            ramipril 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic group 18631
                              organic divalent group 18622
                                organodiyl group 18622
                                  carbonyl group 18537
                                    carbonyl compound 18537
                                      carboxylic acid 18215
                                        carboacyl group 17441
                                          univalent carboacyl group 17441
                                            carbamoyl group 17248
                                              carboxamide 17248
                                                peptide 9456
                                                  oligopeptide 1266
                                                    dipeptide 375
                                                      ramipril 33
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