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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(S)-warfarin
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Accession:CHEBI:87738 term browser browse the term
Definition:A 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one that has (S)-configuration (the racemate is warfarin, an anticoagulant drug and rodenticide).
Synonyms:exact_synonym: 4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one
 related_synonym: (-)-Warfarin;   (S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone;   (S)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one;   4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]-2H-chromen-2-one;   Formula=C19H16O4;   InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3/t15-/m0/s1;   InChIKey=PJVWKTKQMONHTI-HNNXBMFYSA-N;   SMILES=C1=CC=CC2=C1C(=C(C(O2)=O)[C@@H](CC(C)=O)C3=CC=CC=C3)O;   levrowarfarin
 alt_id: CHEBI:45816
 xref: CAS:5543-57-7;   DrugBank:DB14055;   KEGG:C20129;   LINCS:LSM-5404;   PDBeChem:SWF;   PMID:21949493;   PMID:22493814;   PMID:24962085;   PMID:26142522;   PMID:26161443;   PMID:29433307;   PMID:32601017;   PMID:32680916;   PMID:33341662;   PMID:33754183;   PMID:34579970;   PMID:35426132;   PMID:35699912;   PMID:35798369;   PMID:36914276;   PMID:37598356;   PMID:7354137;   Reaxys:4298024
 cyclic_relationship: is_conjugate_acid_of CHEBI:87744;   is_enantiomer_of CHEBI:87737


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warfarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
increases expression		 ISO ABCB1 polymorphism affects the susceptibility to Warfarin
Warfarin results in increased expression of ABCB1A mRNA		 CTD PMID:24092646 PMID:25312789 PMID:27397090 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions
increases response to substance		 ISO [Magnesium deficiency co-treated with Phosphates] promotes the reaction [ABCC6 gene mutant form results in increased susceptibility to Warfarin] CTD PMID:23415960 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects response to substance ISO ABCG2 SNP affects the susceptibility to Warfarin CTD PMID:25300812 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of ACTA2 mRNA CTD PMID:23117658 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Actb actin, beta increases expression
decreases expression		 ISO Warfarin results in increased expression of ACTB mRNA
Warfarin results in decreased expression of ACTB mRNA		 CTD PMID:20493250 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Actr3 actin related protein 3 increases expression ISO Warfarin results in increased expression of ACTR3 mRNA CTD PMID:20493250 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression		 EXP Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of ADIPOQ protein]
Warfarin results in increased expression of ADIPOQ protein		 CTD PMID:27488359 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 mRNA]]; epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 mRNA]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 protein] CTD PMID:36162953 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Ahcy adenosylhomocysteinase decreases expression ISO Warfarin results in decreased expression of AHCY mRNA CTD PMID:20493250 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 6-N,N-diethyl-beta,gamma-dibromomethylene-D-ATP inhibits the reaction [[Warfarin co-treated with Phosphates] results in decreased phosphorylation of AKT1 protein]; [Warfarin co-treated with Phosphates] results in decreased phosphorylation of AKT1 protein; [Warfarin co-treated with Vitamin K 1] results in decreased phosphorylation of AKT1 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased phosphorylation of AKT1 protein] CTD PMID:22659116 PMID:27212383 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions
decreases expression
affects binding		 ISO
EXP		 [Warfarin binds to ALB protein] inhibits the reaction [copper (II) diacetyl-di(N(4)-methylthiosemicarbazone) binds to ALB protein]; [Warfarin binds to ALB protein] inhibits the reaction [copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complex binds to ALB protein]; Aspirin inhibits the reaction [Warfarin binds to ALB protein]; prodan inhibits the reaction [Warfarin binds to ALB protein]; Pyruvaldehyde inhibits the reaction [Warfarin binds to ALB protein]
Warfarin results in decreased expression of ALB protein		 CTD PMID:10506189 PMID:12044178 PMID:18937368 PMID:19596536 PMID:20934417 More... NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression ISO Warfarin results in increased expression of ALOX5AP mRNA CTD PMID:16698924 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO Warfarin inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA] CTD PMID:21910061 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Anxa4 annexin A4 decreases expression ISO Warfarin results in decreased expression of ANXA4 mRNA CTD PMID:20493250 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161 		JBrowse link
G Anxa5 annexin A5 decreases expression ISO Warfarin results in decreased expression of ANXA5 mRNA CTD PMID:20493250 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Apoa1 apolipoprotein A1 affects response to substance ISO APOA1 gene SNP affects the susceptibility to Warfarin CTD PMID:32282500 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apob apolipoprotein B affects response to substance ISO APOB gene SNP affects the susceptibility to Warfarin CTD PMID:31186542 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoe apolipoprotein E increases response to substance
affects response to substance		 ISO APOE gene mutant form results in increased susceptibility to Warfarin
APOE gene mutant form affects the susceptibility to Warfarin; APOE gene polymorphism affects the susceptibility to Warfarin; APOE gene SNP affects the susceptibility to Warfarin; APOE polymorphism affects the susceptibility to Warfarin; APOE protein affects the susceptibility to Warfarin; APOE SNP affects the susceptibility to Warfarin		 CTD PMID:15952022 PMID:16847429 PMID:17048007 PMID:17325732 PMID:21228733 More... NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO Warfarin results in increased expression of ARHGDIA mRNA CTD PMID:20493250 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023 		JBrowse link
G Arsl arylsulfatase L decreases activity ISO Warfarin results in decreased activity of ARSL protein CTD PMID:7720070 NCBI chr 2:119,038,803...119,047,579
Ensembl chr 2:119,038,921...119,046,846 		JBrowse link
G Asph aspartate-beta-hydroxylase affects response to substance ISO ASPH gene SNP affects the susceptibility to Warfarin CTD PMID:27488176 NCBI chr 5:22,601,581...22,814,107
Ensembl chr 5:22,603,486...22,813,876 		JBrowse link
G Axin2 axin 2 multiple interactions
increases expression		 EXP [Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of AXIN2 mRNA] CTD PMID:23117658 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Axl Axl receptor tyrosine kinase multiple interactions
decreases expression
increases response to substance
decreases phosphorylation		 EXP
ISO		 [Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AXL protein]
Warfarin results in decreased expression of AXL protein; Warfarin results in decreased expression of AXL protein modified form
AXL protein promotes the reaction [Warfarin results in increased susceptibility to Gemcitabine]; Vitamin K inhibits the reaction [Warfarin results in decreased expression of AXL protein modified form]; Warfarin inhibits the reaction [GAS6 protein results in increased activity of AXL protein]
AXL protein results in increased susceptibility to Warfarin
Warfarin results in decreased phosphorylation of AXL protein		 CTD PMID:15123721 PMID:26206560 PMID:27212383 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Warfarin co-treated with Vitamin K 1] results in decreased expression of BCL2 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of BCL2 protein] CTD PMID:27212383 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions
increases expression		 ISO
EXP		 Warfarin inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [menaquinone 7 results in increased carboxylation of BGLAP protein]; Warfarin inhibits the reaction [menatetrenone results in increased carboxylation of BGLAP protein]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [Vitamin K 1 results in increased carboxylation of BGLAP protein]
[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of BGLAP protein modified form]
Warfarin results in increased expression of BGLAP mRNA; Warfarin results in increased expression of BGLAP protein modified form		 CTD PMID:21910061 PMID:23117658 PMID:23223575 PMID:27488359 PMID:31173816 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO
EXP		 Warfarin inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; Warfarin inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; Warfarin inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA]
[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA; [Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein]		 CTD PMID:21910061 PMID:27412937 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G C1qbp complement C1q binding protein increases expression ISO Warfarin results in increased expression of C1QBP mRNA CTD PMID:20493250 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Calr calreticulin increases expression ISO Warfarin results in increased expression of CALR mRNA CTD PMID:20493250 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Calu calumenin decreases response to substance
affects response to substance		 EXP
ISO		 CALU protein results in decreased susceptibility to Warfarin
CALU gene SNP affects the susceptibility to Warfarin; CALU polymorphism affects the susceptibility to Warfarin		 CTD PMID:11641264 PMID:20200517 PMID:27632229 NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593 		JBrowse link
G Casp3 caspase 3 decreases expression
increases expression
multiple interactions		 ISO
EXP		 Warfarin results in decreased expression of CASP3 mRNA
Warfarin results in increased expression of CASP3 mRNA
[Warfarin co-treated with Vitamin K 1] results in increased cleavage of CASP3 protein
Warfarin results in increased expression of CASP3 protein modified form		 CTD PMID:19815060 PMID:20493250 PMID:23990204 PMID:26206560 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase increases activity EXP Warfarin results in increased activity of CAT protein CTD PMID:22342526 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions		 EXP Warfarin results in increased expression of CCND1 mRNA
[Warfarin co-treated with Vitamin K] results in increased expression of CCND1 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of CCND1 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of CCND1 mRNA]		 CTD PMID:23117658 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 increases expression ISO Warfarin results in increased expression of CCT5 mRNA CTD PMID:20493250 NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930 		JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A increases expression ISO Warfarin results in increased expression of CCT6A mRNA CTD PMID:20493250 NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337 		JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 decreases expression ISO Warfarin results in decreased expression of CCT8 mRNA CTD PMID:20493250 NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079 		JBrowse link
G Cdc42 cell division cycle 42 decreases expression ISO Warfarin results in decreased expression of CDC42 mRNA CTD PMID:20493250 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO Warfarin results in increased expression of CDH1 protein CTD PMID:26206560 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression ISO Warfarin results in decreased expression of CLIC1 mRNA CTD PMID:20493250 NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712 		JBrowse link
G Cnn1 calponin 1 multiple interactions EXP [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of CNN1 mRNA CTD PMID:23117658 NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression		 ISO
EXP		 Warfarin inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]
Warfarin results in increased expression of COL1A1 mRNA
[Warfarin co-treated with Vitamin K] results in increased expression of COL1A1 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of COL1A1 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of COL1A1 mRNA]		 CTD PMID:21910061 PMID:23117658 PMID:23223575 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 affects response to substance ISO COX15 gene affects the susceptibility to Warfarin CTD PMID:28686080 NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261 		JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression ISO Warfarin results in increased expression of COX5A mRNA CTD PMID:20493250 NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein increases expression ISO Warfarin results in increased expression of CRK mRNA CTD PMID:20493250 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
affects response to substance		 ISO
EXP		 Warfarin results in decreased expression of and affects the localization of CTNNB1 protein
Quercetin inhibits the reaction [Warfarin results in increased expression of and affects the localization of CTNNB1 protein]; Warfarin results in increased expression of and affects the localization of CTNNB1 protein
CTNNB1 protein affects the susceptibility to Warfarin		 CTD PMID:23117658 PMID:23223575 PMID:26206560 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Warfarin results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
affects response to substance		 ISO CYP1A2 protein affects the metabolism of Warfarin
CYP1A2 SNP affects the susceptibility to Warfarin		 CTD PMID:14676821 PMID:15280511 PMID:28079798 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 decreases activity ISO Warfarin results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO Warfarin results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing
affects response to substance		 EXP
ISO		 CYP2C11 protein results in increased metabolism of Warfarin
CYP2C18 gene polymorphism affects the susceptibility to Warfarin; CYP2C18 protein affects the susceptibility to Warfarin		 CTD PMID:19752777 PMID:30724651 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects response to substance
multiple interactions
affects metabolic processing
decreases activity		 ISO CYP2C19 gene polymorphism affects the susceptibility to Warfarin; CYP2C19 polymorphism affects the susceptibility to Warfarin; CYP2C19 protein affects the susceptibility to Warfarin
CYP2C19 gene polymorphism affects the metabolism of and affects the susceptibility to Warfarin; Omeprazole affects the reaction [CYP2C19 protein affects the metabolism of Warfarin]
Warfarin results in decreased activity of CYP2C29 protein		 CTD PMID:18420780 PMID:18520598 PMID:19752777 PMID:25652102 PMID:27356304 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects response to substance ISO CYP2C8 polymorphism affects the susceptibility to Warfarin CTD PMID:34382722
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Warfarin results in decreased activity of CYP2D6 protein CTD PMID:18420780 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
affects response to substance
decreases activity
affects metabolic processing
decreases expression
multiple interactions
affects hydroxylation		 EXP
ISO		 Warfarin results in increased expression of CYP3A2 mRNA
CYP3A2 mRNA affects the susceptibility to Warfarin
Warfarin results in decreased activity of CYP3A4 protein
CYP3A4 SNP affects the susceptibility to Warfarin
CYP3A4 protein affects the metabolism of Warfarin
Warfarin results in decreased expression of CYP3A4 mRNA
[Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CYP3A4 protein affects the hydroxylation of Warfarin		 CTD PMID:2271712 PMID:11531004 PMID:15280511 PMID:16035367 PMID:18420780 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance ISO CYP3A5 gene polymorphism affects the susceptibility to Warfarin; CYP3A5 polymorphism affects the susceptibility to Warfarin; CYP3A5 protein affects the susceptibility to Warfarin CTD PMID:19752777 PMID:34382722 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Dctn2 dynactin subunit 2 decreases expression ISO Warfarin results in decreased expression of DCTN2 mRNA CTD PMID:20493250 NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543 		JBrowse link
G Ddhd1 DDHD domain containing 1 affects response to substance ISO DDHD1 gene SNP affects the susceptibility to Warfarin CTD PMID:27488176 NCBI chr15:18,824,389...18,891,036
Ensembl chr15:18,824,394...18,890,952 		JBrowse link
G Ddt D-dopachrome tautomerase decreases expression ISO Warfarin results in decreased expression of DDT mRNA CTD PMID:20493250 NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase decreases expression ISO Warfarin results in decreased expression of DLST mRNA CTD PMID:20493250 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296 		JBrowse link
G Dock7 dedicator of cytokinesis 7 increases expression ISO Warfarin results in increased expression of DOCK7 mRNA CTD PMID:20493250 NCBI chr 5:113,599,371...113,782,871
Ensembl chr 5:113,600,198...113,782,813 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression ISO Warfarin results in increased expression of DPYSL2 mRNA CTD PMID:20493250 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829 		JBrowse link
G Dstn destrin, actin depolymerizing factor decreases expression ISO Warfarin results in decreased expression of DSTN mRNA CTD PMID:20493250 NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression ISO Warfarin results in decreased expression of EEF2 mRNA CTD PMID:20493250 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I decreases expression ISO Warfarin results in decreased expression of EIF3I mRNA CTD PMID:20493250 NCBI chr 5:141,935,135...141,942,589
Ensembl chr 5:141,935,044...141,942,676 		JBrowse link
G Emcn endomucin decreases expression ISO Warfarin results in decreased expression of EMCN protein CTD PMID:26206560 NCBI chr 2:225,891,100...225,970,932
Ensembl chr 2:225,891,100...225,970,929 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 increases expression EXP Warfarin results in increased expression of ENPP1 mRNA; Warfarin results in increased expression of ENPP1 protein CTD PMID:22659116 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Epha7 Eph receptor A7 affects response to substance ISO EPHA7 promoter SNP affects the susceptibility to Warfarin CTD PMID:30357299 NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases response to substance
affects response to substance		 ISO EPHX1 protein results in increased susceptibility to Warfarin
EPHX1 gene polymorphism affects the susceptibility to Warfarin; EPHX1 gene SNP affects the susceptibility to Warfarin; EPHX1 intron SNP affects the susceptibility to Warfarin; EPHX1 polymorphism affects the susceptibility to Warfarin; EPHX1 SNP affects the susceptibility to Warfarin		 CTD PMID:15900282 PMID:17496169 PMID:20842355 PMID:21192345 PMID:24092646 More... NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression ISO Warfarin results in decreased expression of ERP29 mRNA CTD PMID:20493250 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G F10 coagulation factor X decreases activity EXP Warfarin results in decreased activity of F10 protein CTD PMID:3490277 PMID:20371969 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions
affects response to substance
decreases expression
decreases activity		 ISO
EXP		 Fenofibrate promotes the reaction [Warfarin results in decreased expression of F2 protein]
F2 gene polymorphism affects the susceptibility to Warfarin
Warfarin results in decreased activity of F2 protein		 CTD PMID:3490277 PMID:9681093 PMID:14656880 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F5 coagulation factor V affects response to substance
decreases activity		 ISO
EXP		 F5 gene polymorphism affects the susceptibility to Warfarin; F5 protein affects the susceptibility to Warfarin
Warfarin results in decreased activity of F5 protein		 CTD PMID:3490277 PMID:19752777 NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317 		JBrowse link
G F7 coagulation factor VII affects response to substance
decreases expression
multiple interactions
decreases activity		 ISO
EXP		 F7 gene mutant form affects the susceptibility to Warfarin; F7 gene polymorphism affects the susceptibility to Warfarin
Warfarin results in decreased expression of F7 protein
Fenofibrate promotes the reaction [Warfarin results in decreased expression of F7 protein]
Warfarin results in decreased activity of F7 protein		 CTD PMID:3490277 PMID:9681093 PMID:14656880 PMID:20371969 PMID:20885134 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G F9 coagulation factor IX decreases activity
increases response to substance		 EXP
ISO		 Warfarin results in decreased activity of F9 protein
F9 gene alternative form results in increased susceptibility to Warfarin		 CTD PMID:3490277 PMID:29450643 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835 		JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions EXP Warfarin inhibits the reaction [3-(p-azidobenzyl)-4-hydroxycoumarin binds to Fabp1 protein] RGD PMID:1939124 RGD:1626448 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fgf5 fibroblast growth factor 5 affects response to substance ISO FGF5 gene affects the susceptibility to Warfarin CTD PMID:28686080 NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997 		JBrowse link
G Fpgs folylpolyglutamate synthase affects response to substance ISO FPGS gene polymorphism affects the susceptibility to Warfarin CTD PMID:25079360 NCBI chr 3:15,972,800...15,993,592
Ensembl chr 3:15,972,800...15,993,563 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression ISO Warfarin results in decreased expression of FSCN1 mRNA CTD PMID:20493250 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211 		JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 increases expression ISO Warfarin results in increased expression of G3BP1 mRNA CTD PMID:20493250 NCBI chr10:39,586,864...39,620,268
Ensembl chr10:39,586,864...39,620,268 		JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 increases expression ISO Warfarin results in increased expression of GAL3ST1 mRNA CTD PMID:27397090 NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388 		JBrowse link
G Gale UDP-galactose-4-epimerase decreases expression ISO Warfarin results in decreased expression of GALE mRNA CTD PMID:20493250 NCBI chr 5:148,193,886...148,198,392
Ensembl chr 5:148,194,791...148,198,388 		JBrowse link
G Gas6 growth arrest specific 6 decreases expression
multiple interactions
decreases carboxylation		 EXP
ISO		 Warfarin results in decreased expression of GAS6 protein
[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein]; Warfarin results in decreased activity of and results in decreased carboxylation of GAS6 protein
Warfarin results in decreased carboxylation of GAS6 protein
Warfarin inhibits the reaction [GAS6 protein results in increased activity of AXL protein]		 CTD PMID:9163328 PMID:19564549 PMID:26206560 PMID:27212383 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gata4 GATA binding protein 4 affects response to substance ISO GATA4 gene SNP affects the susceptibility to Warfarin CTD PMID:31190750 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gata6 GATA binding protein 6 affects response to substance ISO GATA6 gene SNP affects the susceptibility to Warfarin CTD PMID:31190750 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Gdi2 GDP dissociation inhibitor 2 increases expression ISO Warfarin results in increased expression of GDI2 mRNA CTD PMID:20493250 NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO Warfarin results in increased expression of GFAP mRNA; Warfarin results in increased expression of GFAP protein CTD PMID:27397090 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Ggcx gamma-glutamyl carboxylase affects response to substance
decreases response to substance
increases response to substance
increases activity		 ISO
EXP		 GGCX gene polymorphism affects the susceptibility to Warfarin; GGCX gene SNP affects the susceptibility to Warfarin; GGCX polymorphism affects the susceptibility to Warfarin
GGCX gene polymorphism results in decreased susceptibility to Warfarin
GGCX protein results in increased susceptibility to Warfarin
Warfarin results in increased activity of GGCX protein		 CTD PMID:3490277 PMID:16676068 PMID:17049586 PMID:17496169 PMID:17764537 More... NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063 		JBrowse link
G Gmps guanine monophosphate synthase increases expression ISO Warfarin results in increased expression of GMPS mRNA CTD PMID:20493250 NCBI chr 2:148,441,369...148,491,908
Ensembl chr 2:148,435,643...148,485,875 		JBrowse link
G Gprc6a G protein-coupled receptor, class C, group 6, member A multiple interactions EXP Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GPRC6A mRNA] CTD PMID:27488359 NCBI chr20:30,922,106...30,943,412
Ensembl chr20:30,922,106...30,943,412 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein] CTD PMID:23117658 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hdac1 histone deacetylase 1 increases expression ISO Warfarin results in increased expression of HDAC1 mRNA CTD PMID:20493250 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein] CTD PMID:36162953 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression ISO Warfarin results in increased expression of HINT1 mRNA CTD PMID:20493250 NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of HMGCR mRNA] CTD PMID:27488359 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression EXP Warfarin affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B increases expression ISO Warfarin results in increased expression of HNRNPAB mRNA CTD PMID:20493250 NCBI chr10:35,857,040...35,862,935
Ensembl chr10:35,857,041...35,863,344 		JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Warfarin results in decreased expression of HNRNPDL mRNA CTD PMID:20493250 NCBI chr14:9,557,430...9,563,659
Ensembl chr14:9,557,425...9,562,506 		JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F increases expression ISO Warfarin results in increased expression of HNRNPF mRNA CTD PMID:20493250 NCBI chr 4:151,083,262...151,104,464
Ensembl chr 4:151,083,062...151,109,038 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K increases expression
decreases expression		 ISO Warfarin results in increased expression of HNRNPK mRNA
Warfarin results in decreased expression of HNRNPK mRNA		 CTD PMID:20493250 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Hp haptoglobin increases expression EXP Warfarin results in increased expression of HP protein CTD PMID:22342526 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO Warfarin results in decreased expression of HSP90AB1 mRNA CTD PMID:20493250 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO Warfarin results in increased expression of HSPA8 mRNA CTD PMID:20493250 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO Warfarin results in increased expression of HSPD1 mRNA CTD PMID:20493250 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Il12a interleukin 12A increases expression EXP Warfarin results in increased expression of IL12A mRNA CTD PMID:22342526 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B increases expression EXP Warfarin results in increased expression of IL12B mRNA CTD PMID:22342526 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO
EXP		 Warfarin inhibits the reaction [Vitamin K 2 results in decreased susceptibility to IL1B protein]
[Warfarin co-treated with Vitamin K] results in increased expression of IL1B mRNA
Warfarin results in decreased expression of IL1B mRNA		 CTD PMID:20460758 PMID:23117658 PMID:29594315 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Warfarin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 increases expression
decreases expression
decreases secretion
multiple interactions		 EXP
ISO		 Warfarin results in increased expression of IL6 protein
Warfarin results in decreased expression of IL6 protein
Warfarin results in decreased secretion of IL6 protein
Warfarin results in decreased expression of IL6 mRNA
[Warfarin co-treated with Vitamin K] results in increased expression of IL6 mRNA		 CTD PMID:18772604 PMID:22342526 PMID:23117658 PMID:26742017 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 increases secretion
multiple interactions		 EXP Warfarin results in increased secretion of INS1 protein
Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased secretion of INS1 protein]		 CTD PMID:27488359 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ipo5 importin 5 decreases expression ISO Warfarin results in decreased expression of IPO5 mRNA CTD PMID:20493250 NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126 		JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 increases expression ISO Warfarin results in increased expression of ISYNA1 mRNA CTD PMID:20493250 NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979 		JBrowse link
G Krt18 keratin 18 decreases expression ISO Warfarin results in decreased expression of KRT18 mRNA CTD PMID:20493250 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Lasp1 LIM and SH3 protein 1 decreases expression ISO Warfarin results in decreased expression of LASP1 mRNA CTD PMID:20493250 NCBI chr10:82,795,177...82,835,659
Ensembl chr10:82,795,137...82,943,292 		JBrowse link
G Lrp1 LDL receptor related protein 1 affects response to substance ISO LRP1 gene SNP affects the susceptibility to Warfarin CTD PMID:32282500 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] CTD PMID:36162953 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] CTD PMID:36162953 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mgp matrix Gla protein multiple interactions
decreases carboxylation		 ISO
EXP		 [[Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein] which results in decreased activity of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased activity of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased expression of MGP mRNA
[Quercetin co-treated with Warfarin] results in decreased carboxylation of MGP protein; [Vitamin K co-treated with Warfarin] results in increased carboxylation of MGP protein; Warfarin inhibits the reaction [Vitamin K 1 results in increased expression of and results in increased secretion of MGP protein modified form]; Warfarin results in decreased expression of and results in decreased secretion of MGP protein; Warfarin results in decreased expression of and results in decreased secretion of MGP protein modified form
Warfarin results in decreased carboxylation of MGP protein		 CTD PMID:21705322 PMID:23223575 PMID:23990204 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667 		JBrowse link
G Mir3582 microRNA 3582 affects response to substance ISO MIR133A2 gene SNP affects the susceptibility to Warfarin CTD PMID:26113018 NCBI chr18:1,885,063...1,885,180
Ensembl chr18:1,885,063...1,885,180 		JBrowse link
G Mpo myeloperoxidase increases activity EXP Warfarin results in increased activity of MPO protein CTD PMID:26742017 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myh1 myosin heavy chain 1 multiple interactions EXP [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of MYH1 mRNA CTD PMID:23117658 NCBI chr10:51,885,913...51,909,699
Ensembl chr10:51,885,913...51,946,295 		JBrowse link
G Myh6 myosin heavy chain 6 affects response to substance ISO MYH6 polymorphism affects the susceptibility to Warfarin CTD PMID:34515533 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase affects response to substance ISO NEDD4 gene SNP affects the susceptibility to Warfarin CTD PMID:27488176 NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951 		JBrowse link
G Nmral1 NmrA like redox sensor 1 increases expression ISO Warfarin results in increased expression of NMRAL1 mRNA CTD PMID:20493250 NCBI chr10:10,841,693...10,850,199
Ensembl chr10:10,841,799...10,850,192 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects response to substance ISO NQO1 gene SNP affects the susceptibility to Warfarin; NQO1 polymorphism affects the susceptibility to Warfarin CTD PMID:23215885 PMID:26257249 PMID:27581200 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
decreases expression		 ISO [Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA; [Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Warfarin binds to and results in increased activity of NR1I2 protein
Warfarin results in decreased expression of NR1I2 mRNA		 CTD PMID:20735727 PMID:30963258 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nucb1 nucleobindin 1 increases expression ISO Warfarin results in increased expression of NUCB1 mRNA CTD PMID:20493250 NCBI chr 1:95,968,325...95,999,183
Ensembl chr 1:95,968,326...96,003,220 		JBrowse link
G Numb NUMB, endocytic adaptor protein multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA] CTD PMID:23117658 NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354 		JBrowse link
G Oat ornithine aminotransferase decreases expression ISO Warfarin results in decreased expression of OAT mRNA CTD PMID:20493250 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Orm1 orosomucoid 1 multiple interactions
affects response to substance
increases response to substance
affects binding		 ISO Chlorpromazine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Dipyridamole inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Lidocaine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Progesterone inhibits the reaction [Warfarin binds to ORM1 protein alternative form]
ORM1 gene polymorphism affects the susceptibility to Warfarin; ORM1 polymorphism affects the susceptibility to Warfarin
ORM1 protein results in increased susceptibility to Warfarin		 CTD PMID:8946472 PMID:17496169 PMID:23208322 PMID:26644206 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Pa2g4 proliferation-associated 2G4 increases expression ISO Warfarin results in increased expression of PA2G4 mRNA CTD PMID:20493250 NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO Warfarin results in increased expression of PARP1 protein modified form CTD PMID:26206560 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression EXP Warfarin results in decreased expression of PDGFB mRNA; Warfarin results in decreased expression of PDGFB protein CTD PMID:11290560 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression
decreases expression		 ISO Warfarin results in increased expression of PDIA3 mRNA
Warfarin results in decreased expression of PDIA3 mRNA		 CTD PMID:20493250 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 decreases expression ISO Warfarin results in decreased expression of PDIA4 mRNA CTD PMID:20493250 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression
increases expression		 ISO Warfarin results in decreased expression of PGAM1 mRNA
Warfarin results in increased expression of PGAM1 mRNA		 CTD PMID:20493250 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452 		JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO Warfarin results in decreased expression of PKM mRNA CTD PMID:20493250 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Plp1 proteolipid protein 1 increases expression ISO Warfarin results in increased expression of PLP1 mRNA CTD PMID:27397090 NCBI chr  X:100,184,039...100,201,035
Ensembl chr  X:100,185,767...100,201,032 		JBrowse link
G Por cytochrome p450 oxidoreductase affects response to substance ISO POR gene SNP affects the susceptibility to Warfarin CTD PMID:27488389 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases expression ISO Warfarin results in decreased expression of PPP1CA mRNA CTD PMID:20493250 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression ISO Warfarin results in increased expression of PPP2R1A mRNA CTD PMID:20493250 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa increases response to substance
affects response to substance		 ISO PROC protein results in increased susceptibility to Warfarin
PROC gene polymorphism affects the susceptibility to Warfarin		 CTD PMID:17048007 PMID:17496169 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Pros1 protein S affects response to substance ISO PROS1 gene polymorphism affects the susceptibility to Warfarin; PROS1 protein affects the susceptibility to Warfarin CTD PMID:19752777 NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286 		JBrowse link
G Prss53 serine protease 53 affects response to substance ISO PRSS53 gene SNP affects the susceptibility to Warfarin CTD PMID:21590310 NCBI chr 1:182,494,944...182,501,607
Ensembl chr 1:182,494,955...182,500,115 		JBrowse link
G Psma3 proteasome 20S subunit alpha 3 decreases expression ISO Warfarin results in decreased expression of PSMA3 mRNA CTD PMID:20493250 NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965 		JBrowse link
G Psma6 proteasome 20S subunit alpha 6 decreases expression ISO Warfarin results in decreased expression of PSMA6 mRNA CTD PMID:20493250 NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:72,765,473...72,796,554 		JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 decreases expression ISO Warfarin results in decreased expression of PSMC2 mRNA CTD PMID:20493250 NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185 		JBrowse link
G Pth parathyroid hormone decreases activity ISO Warfarin results in decreased activity of PTH protein CTD PMID:11564701 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Rab1a RAB1A, member RAS oncogene family decreases expression ISO Warfarin results in decreased expression of RAB1A mRNA CTD PMID:20493250 NCBI chr14:94,422,219...94,448,799
Ensembl chr14:94,415,275...94,448,248 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Warfarin results in decreased expression of RHOA mRNA CTD PMID:20493250 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rpl27 ribosomal protein L27 increases expression ISO Warfarin results in increased expression of RPL27 mRNA CTD PMID:20493250 NCBI chr10:86,375,511...86,379,210
Ensembl chr10:86,375,454...86,379,193 		JBrowse link
G Rpl9 ribosomal protein L9 increases expression ISO Warfarin results in increased expression of RPL9 mRNA CTD PMID:20493250 NCBI chr14:42,893,945...42,897,140
Ensembl chr14:42,893,942...42,897,136
Ensembl chr 3:42,893,942...42,897,136 		JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression ISO Warfarin results in increased expression of RPLP0 mRNA CTD PMID:20493250 NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RPS6KB1 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RPS6KB1 protein] CTD PMID:36162953 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rpsa ribosomal protein SA increases expression ISO Warfarin results in increased expression of RPSA mRNA CTD PMID:20493250 NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247 		JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression
multiple interactions		 EXP Warfarin results in increased expression of RUNX1 mRNA
Quercetin inhibits the reaction [Warfarin results in increased expression of RUNX1 mRNA]		 CTD PMID:23223575 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO
EXP		 Warfarin inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA]
[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA; [Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein; [Warfarin co-treated with Vitamin K] results in increased expression of RUNX2 mRNA; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein]; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of RUNX2 mRNA]		 CTD PMID:21910061 PMID:23117658 PMID:27412937 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 decreases expression ISO Warfarin results in decreased expression of RUVBL2 mRNA CTD PMID:20493250 NCBI chr 1:95,902,014...95,915,247
Ensembl chr 1:95,901,701...95,915,342 		JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression ISO Warfarin results in decreased expression of SAE1 mRNA CTD PMID:20493250 NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986 		JBrowse link
G Sephs1 selenophosphate synthetase 1 increases expression ISO Warfarin results in increased expression of SEPHS1 mRNA CTD PMID:20493250 NCBI chr17:73,354,435...73,382,803
Ensembl chr17:73,356,530...73,382,593 		JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Warfarin results in increased expression of SERPINC1 protein CTD PMID:73932 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 affects response to substance ISO SLC15A2 gene SNP affects the susceptibility to Warfarin CTD PMID:29234073 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 affects response to substance ISO SLCO1B3 gene SNP affects the susceptibility to Warfarin CTD PMID:29234073 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Sost sclerostin affects response to substance ISO SOST affects the susceptibility to Warfarin CTD PMID:35038187 NCBI chr10:86,912,517...86,915,561
Ensembl chr10:86,911,517...86,915,561 		JBrowse link
G Sox5 SRY-box transcription factor 5 affects localization
decreases expression		 ISO Warfarin affects the localization of SOX5 protein
Warfarin results in decreased expression of SOX5 mRNA; Warfarin results in decreased expression of SOX5 protein		 CTD PMID:34520801 NCBI chr 4:176,781,375...177,736,833
Ensembl chr 4:176,785,892...177,736,852 		JBrowse link
G Sox9 SRY-box transcription factor 9 affects localization
multiple interactions		 ISO Warfarin affects the localization of SOX9 protein
leptomycin B inhibits the reaction [Warfarin affects the localization of SOX9 protein]		 CTD PMID:34520801 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO Warfarin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA] CTD PMID:21910061 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO
EXP		 [Warfarin co-treated with Vitamin K 1] results in increased expression of SPP1 mRNA
[Quercetin co-treated with Warfarin] results in increased expression of SPP1 mRNA; [Warfarin co-treated with Vitamin K] results in increased expression of SPP1 mRNA		 CTD PMID:23117658 PMID:23223575 PMID:23990204 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Warfarin results in decreased expression of STIP1 mRNA CTD PMID:20493250 NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476 		JBrowse link
G Tagln transgelin multiple interactions ISO
EXP		 [Warfarin co-treated with Vitamin K 1] results in decreased expression of TAGLN mRNA
[Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of TAGLN mRNA		 CTD PMID:23117658 PMID:23990204 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668 		JBrowse link
G Tcf4 transcription factor 4 increases expression
multiple interactions		 EXP Warfarin results in increased expression of TCF4 mRNA
[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of TCF4 mRNA]		 CTD PMID:23117658 NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425 		JBrowse link
G Tcp1 t-complex 1 increases expression ISO Warfarin results in increased expression of TCP1 mRNA CTD PMID:20493250 NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839 		JBrowse link
G Tgm2 transglutaminase 2 affects response to substance
increases response to substance
multiple interactions		 ISO
EXP		 [TGM2 protein affects the susceptibility to Warfarin] which affects the susceptibility to Quercetin; TGM2 protein affects the susceptibility to Warfarin
TGM2 protein results in increased susceptibility to Warfarin
[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein]; Quercetin inhibits the reaction [Warfarin results in increased activity of TGM2 protein]; Warfarin results in increased expression of and results in increased activity of TGM2 protein		 CTD PMID:23117658 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981 		JBrowse link
G Thop1 thimet oligopeptidase 1 increases expression ISO Warfarin results in increased expression of THOP1 mRNA CTD PMID:20493250 NCBI chr 7:8,632,911...8,645,339
Ensembl chr 7:8,632,916...8,645,275 		JBrowse link
G Tnf tumor necrosis factor decreases expression
decreases secretion
multiple interactions
increases expression		 EXP Warfarin results in decreased expression of TNF mRNA
Warfarin results in decreased secretion of TNF protein
[Warfarin co-treated with Vitamin K] results in increased expression of TNF mRNA
Warfarin results in increased expression of TNF		 CTD PMID:21565690 PMID:22342526 PMID:23117658 PMID:26742017 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases degradation
increases expression		 ISO Warfarin results in increased degradation of TP53 protein
Warfarin results in increased expression of TRP53 mRNA; Warfarin results in increased expression of TRP53 protein		 CTD PMID:14634213 PMID:29358327 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tuba1a tubulin, alpha 1A increases expression ISO Warfarin results in increased expression of TUBA1A mRNA CTD PMID:20493250 NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tuba1b tubulin, alpha 1B decreases expression
increases expression		 ISO Warfarin results in decreased expression of TUBA1B mRNA
Warfarin results in increased expression of TUBA1B mRNA		 CTD PMID:20493250 NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO Warfarin results in decreased expression of TUBB5 mRNA CTD PMID:20493250 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940 		JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases expression ISO Warfarin results in decreased expression of TUFM mRNA CTD PMID:20493250 NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395 		JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase decreases expression ISO Warfarin results in decreased expression of TYRO3 mRNA CTD PMID:18772604 PMID:27397090 NCBI chr 3:106,777,686...106,797,154
Ensembl chr 3:106,777,635...106,797,142 		JBrowse link
G U2af2 U2 small nuclear RNA auxiliary factor 2 increases expression ISO Warfarin results in increased expression of U2AF2 mRNA CTD PMID:20493250 NCBI chr 1:68,760,911...68,779,730
Ensembl chr 1:68,760,924...68,778,492 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases metabolic processing
affects response to substance		 ISO [UGT1A1 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of Glucuronides; [Warfarin binds to and results in decreased activity of UGT1A1 protein] which results in decreased glucuronidation of Estradiol; Warfarin binds to and results in decreased activity of UGT1A1 protein; Warfarin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]
UGT1A1 gene SNP affects the susceptibility to Warfarin; UGT1A1 polymorphism affects the susceptibility to Warfarin		 CTD PMID:19408964 PMID:25312789 PMID:25393417 PMID:26223945 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [Warfarin binds to and results in increased activity of UGT1A3 protein] which results in increased glucuronidation of vorinostat; Warfarin binds to and results in increased activity of UGT1A3 protein; Warfarin promotes the reaction [UGT1A3 protein results in increased glucuronidation of vorinostat] CTD PMID:25393417 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO [Warfarin binds to and affects the activity of UGT1A9 protein] which affects the glucuronidation of Propofol; Warfarin affects the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; Warfarin binds to and affects the activity of UGT1A9 protein CTD PMID:25393417 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 multiple interactions ISO [Warfarin binds to and results in decreased activity of UGT2B17 protein] which results in decreased glucuronidation of vorinostat; Warfarin binds to and results in decreased activity of UGT2B17 protein; Warfarin inhibits the reaction [UGT2B17 protein results in increased glucuronidation of vorinostat] CTD PMID:25393417 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [Warfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; Warfarin binds to and results in decreased activity of UGT2B7 protein; Warfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine] CTD PMID:25393417 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Usp5 ubiquitin specific peptidase 5 decreases expression ISO Warfarin results in decreased expression of USP5 mRNA CTD PMID:20493250 NCBI chr 4:157,619,663...157,634,681
Ensembl chr 4:157,619,643...157,634,711 		JBrowse link
G Vcp valosin-containing protein decreases expression
increases expression		 ISO Warfarin results in decreased expression of VCP mRNA
Warfarin results in increased expression of VCP mRNA		 CTD PMID:20493250 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
G Vdr vitamin D receptor affects response to substance ISO VDR gene SNP affects the susceptibility to Warfarin CTD PMID:28262345 PMID:29298995 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A affects response to substance
multiple interactions		 ISO VEGFA gene SNP affects the susceptibility to Warfarin
epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA mRNA]]; epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA mRNA]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA protein]		 CTD PMID:31068094 PMID:36162953 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin decreases expression ISO Warfarin results in decreased expression of VIM protein CTD PMID:26206560 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 multiple interactions
decreases metabolic processing
increases response to substance
affects metabolic processing
decreases response to substance
decreases activity
affects response to substance
affects abundance		 ISO
EXP		 [CYP4F2 gene polymorphism co-treated with VKORC1 gene mutant form] affects the susceptibility to Warfarin; Warfarin binds to and results in decreased activity of VKORC1 protein; Warfarin inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; Warfarin inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]
VKORC1 gene polymorphism results in decreased metabolism of Warfarin
VKORC1 intron polymorphism results in increased susceptibility to Warfarin; VKORC1 protein results in increased susceptibility to Warfarin; VKORC1 results in increased susceptibility to Warfarin
VKORC1 protein affects the metabolism of Warfarin
VKORC1 gene mutant form results in decreased susceptibility to Warfarin; VKORC1 protein polymorphism results in decreased susceptibility to Warfarin
Warfarin results in decreased activity of VKORC1 protein
VKORC1 protein mutant form affects the susceptibility to Warfarin
Warfarin inhibits the reaction [VKORC1 protein affects the reduction of vitamin K1 oxide]
VKORC1 3' UTR SNP affects the susceptibility to Warfarin; VKORC1 affects the susceptibility to Warfarin; VKORC1 alternative form affects the susceptibility to Warfarin; VKORC1 gene affects the susceptibility to Warfarin; VKORC1 gene mutant form affects the susceptibility to Warfarin; VKORC1 gene polymorphism affects the susceptibility to Warfarin; VKORC1 gene SNP affects the susceptibility to Warfarin; VKORC1 intron polymorphism affects the susceptibility to Warfarin; VKORC1 intron SNP affects the susceptibility to Warfarin; VKORC1 polymorphism affects the susceptibility to Warfarin; VKORC1 promoter polymorphism affects the susceptibility to Warfarin; VKORC1 promoter SNP affects the susceptibility to Warfarin; VKORC1 protein affects the susceptibility to Warfarin; VKORC1 protein polymorphism affects the susceptibility to Warfarin; VKORC1 protein SNP affects the susceptibility to Warfarin; VKORC1 SNP affects the susceptibility to Warfarin
VKORC1 3' UTR results in decreased susceptibility to Warfarin; VKORC1 gene mutant form results in decreased susceptibility to Warfarin; VKORC1 gene polymorphism results in decreased susceptibility to Warfarin
VKORC1 gene polymorphism affects the abundance of Warfarin		 CTD PMID:14765194 PMID:14765195 PMID:15358623 PMID:15578879 PMID:15630486 More... NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions ISO
EXP		 Warfarin affects the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]; Warfarin binds to and results in decreased activity of VKORC1L1 protein; Warfarin inhibits the reaction [VKORC1L1 protein results in increased metabolism of vitamin K1 oxide]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide] CTD PMID:23710884 PMID:23928358 PMID:29581108 NCBI chr12:26,717,959...26,768,193
Ensembl chr12:26,623,976...26,768,225 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon increases expression ISO Warfarin results in increased expression of YWHAE mRNA CTD PMID:20493250 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO Warfarin results in decreased expression of ZEB1 protein CTD PMID:26206560 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      group 19768
        inorganic group 19361
          oxo group 18858
            organic oxo compound 18858
              carbonyl compound 18858
                ketone 17163
                  methyl ketone 815
                    4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one 194
                      (S)-warfarin 194
                        warfarin 194
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                organic heterocyclic compound 18862
                                  oxacycle 17819
                                    benzopyran 11950
                                      1-benzopyran 11702
                                        chromenes 4418
                                          chromenone 4370
                                            coumarins 4140
                                              hydroxycoumarin 352
                                                4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one 194
                                                  (S)-warfarin 194
                                                    warfarin 194
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