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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ranolazine
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Accession:CHEBI:87681 term browser browse the term
Definition:A racemate comprising equal amounts of (R)- and (S)-ranolazine. Used for treatment of chronic angina.
Synonyms:exact_synonym: rac-N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide
 related_synonym: (+-)-N-(2,6-Dimethylphenyl)-4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-1-piperazineacetamide;   (RS)-ranolazine;   Formula=C24H33N3O4;   Ranexa;   rac-ranolazine;   racemic ranolazine
 xref: CAS:95635-55-5;   DrugBank:DB00243;   KEGG:D05700
 xref_mesh: MESH:D000069458
 xref: PMID:25041234;   PMID:25188881;   PMID:25210025;   PMID:25346368;   PMID:25346483;   PMID:25416563;   PMID:25496982;   PMID:25515836;   PMID:25544118;   PMID:25555283;   PMID:25602175;   PMID:25738014;   PMID:25761430;   PMID:25828315;   PMID:25848292;   PMID:25872749;   PMID:26021246;   PMID:26049552;   PMID:26049922;   PMID:26059896;   PMID:26138210;   PMID:26183665;   PMID:26185330;   PMID:26226999;   PMID:26245658;   Patent:EP126449;   Patent:US4567264;   Reaxys:8234797;   Wikipedia:Ranolazine


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ranolazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Ranolazine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Ranolazine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
ISO Ranolazine results in decreased activity of KCNH2 protein
Ranolazine inhibits the reaction [arsenic trioxide results in increased degradation of KCNH2 protein]
CTD PMID:24052561 PMID:28521025 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 multiple interactions ISO Ranolazine inhibits the reaction [2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate results in increased activity of SCN5A protein] CTD PMID:29306026 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      chemical substance 12981
        mixture 12153
          racemate 10095
            ranolazine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                monocarboxylic acid amide 15014
                                                  N-(2,6-dimethylphenyl)-2-\{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl\}acetamide 3
                                                    (S)-ranolazine 3
                                                      ranolazine 3
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