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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tolonium chloride
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Accession:CHEBI:87647 term browser browse the term
Definition:An organic chloride salt having 3-amino-7-(dimethylamino)-2-methylphenothiazin-5-ium (tolonium) as the counterion. It is a blue nuclear counterstain that can be used to demonstrate Nissl substance and is also useful for staining mast cell granules, both in metachromatic and orthochromatic techniques.
Synonyms:exact_synonym: 3-amino-7-(dimethylamino)-2-methylphenothiazin-5-ium chloride
 related_synonym: 3-Amino-7-(dimethylamino)-2-(methylphenazathionium) chloride;   Blutene chloride;   C.I. 52040;   C.I. 925;   C.I. Basic Blue 17;   Dimethyltoluthionine chloride;   Formula=C15H16ClN3S;   InChI=1S/C15H16N3S.ClH/c1-9-6-13-15(8-11(9)16)19-14-7-10(18(2)3)4-5-12(14)17-13;/h4-8H,16H2,1-3H3;1H/q+1;/p-1;   InChIKey=HNONEKILPDHFOL-UHFFFAOYSA-M;   SMILES=[Cl-].CN(C)c1ccc2nc3cc(C)c(N)cc3[s+]c2c1;   Toluidene Blue O Chloride;   Toluidinblau;   basic blue 17;   chlorure de tolonium;   cloruro de tolonio;   toloni chloridum;   tolonii chloridum;   toluidine blue;   toluidine blue O
 xref: CAS:92-31-9
 xref_mesh: MESH:D014048
 xref: PMID:23884903;   PMID:24981641;   PMID:25463317;   PMID:25670474;   PMID:25752750;   PMID:25910445;   PMID:25972050;   PMID:26055566;   Reaxys:3580048;   Wikipedia:Tolonium_chloride


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tolonium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Tolonium Chloride results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G App amyloid beta precursor protein decreases secretion EXP Tolonium Chloride results in decreased secretion of APP protein modified form CTD PMID:36027949 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 multiple interactions EXP Tolonium Chloride results in decreased expression of and results in decreased activity of BACE1 protein CTD PMID:36027949 NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697 		JBrowse link
G Cdk5 cyclin dependent kinase 5 decreases expression EXP Tolonium Chloride results in decreased expression of CDK5 protein CTD PMID:36027949 NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528 		JBrowse link
G Fyn Fyn proto-oncogene decreases expression EXP Tolonium Chloride results in decreased expression of FYN protein CTD PMID:36027949 NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression
increases phosphorylation		 EXP Tolonium Chloride results in decreased expression of GSK3B protein
Tolonium Chloride results in increased phosphorylation of GSK3B protein		 CTD PMID:36027949 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP Tolonium Chloride results in decreased expression of and results in decreased phosphorylation of MAPT protein CTD PMID:36027949 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916 		JBrowse link
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform decreases phosphorylation EXP Tolonium Chloride results in decreased phosphorylation of PPP2CA protein CTD PMID:36027949 NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605 		JBrowse link
G Psen1 presenilin 1 decreases expression EXP Tolonium Chloride results in decreased expression of PSEN1 protein modified form CTD PMID:36027949 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      application 21744
        dye 2969
          histological dye 252
            tolonium chloride 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      halogen 20279
                        chlorine atom 19728
                          chlorine molecular entity 19758
                            elemental chlorine 8343
                              monoatomic chlorine 8326
                                chloride 8326
                                  chloride salt 8336
                                    organic chloride salt 1102
                                      tolonium chloride 9
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