Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium
go back to main search page
Accession:CHEBI:87640 term browser browse the term
Definition:An organic cation that is phenothiazin-5-ium substituted by dimethylamino and amino groups at positions 3 and 7 respectively. The chloride salt is the histological dye 'azure B'.
Synonyms:related_synonym: Formula=C15H16N3S;   InChI=1S/C15H16N3S/c1-16-10-4-6-12-14(8-10)19-15-9-11(18(2)3)5-7-13(15)17-12/h4-9,16H,1-3H3/q+1;   InChIKey=VBFJMDUNUIVOMH-UHFFFAOYSA-N;   SMILES=CNc1ccc2nc3ccc(cc3[s+]c2c1)N(C)C;   azure B cation;   azure B(1+)


show annotations for term's descendants           Sort by:
 
azure B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form; Azure B results in decreased expression of and affects the cleavage of APP protein CTD PMID:30500345 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bace1 beta-secretase 1 decreases activity ISO Azure B results in decreased activity of BACE1 protein CTD PMID:30500345 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19801
    chemical entity 19800
      molecular entity 19796
        ion 15926
          organic ion 8319
            organic cation 7138
              3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium 2
                azure B 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19801
    subatomic particle 19797
      composite particle 19797
        hadron 19797
          baryon 19797
            nucleon 19797
              atomic nucleus 19797
                atom 19797
                  main group element atom 19684
                    main group molecular entity 19684
                      p-block molecular entity 19684
                        carbon group molecular entity 19583
                          organic molecular entity 19572
                            organic ion 8319
                              organic cation 7138
                                3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium 2
                                  azure B 2
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.