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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium
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Accession:CHEBI:87640 term browser browse the term
Definition:An organic cation that is phenothiazin-5-ium substituted by dimethylamino and amino groups at positions 3 and 7 respectively. The chloride salt is the histological dye 'azure B'.
Synonyms:related_synonym: Formula=C15H16N3S;   InChI=1S/C15H16N3S/c1-16-10-4-6-12-14(8-10)19-15-9-11(18(2)3)5-7-13(15)17-12/h4-9,16H,1-3H3/q+1;   InChIKey=VBFJMDUNUIVOMH-UHFFFAOYSA-N;   SMILES=CNc1ccc2nc3ccc(cc3[s+]c2c1)N(C)C;   azure B cation;   azure B(1+)


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azure B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta (A4) precursor protein multiple interactions ISO [Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form; Azure B results in decreased expression of and affects the cleavage of APP protein CTD PMID:30500345 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
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G Bace1 beta-site APP cleaving enzyme 1 decreases activity ISO Azure B results in decreased activity of BACE1 protein CTD PMID:30500345 NCBI chr 9:45,838,545...45,862,484
Ensembl chr 9:45,838,580...45,864,399
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21416
    chemical entity 21414
      molecular entity 21408
        ion 16484
          organic ion 8467
            organic cation 7246
              3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium 2
                azure B 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 21416
    subatomic particle 21412
      composite particle 21412
        hadron 21412
          baryon 21412
            nucleon 21412
              atomic nucleus 21412
                atom 21412
                  main group element atom 21307
                    main group molecular entity 21307
                      p-block molecular entity 21306
                        carbon group molecular entity 21082
                          organic molecular entity 20979
                            organic ion 8467
                              organic cation 7246
                                3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium 2
                                  azure B 2
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