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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium
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Accession:CHEBI:87640 term browser browse the term
Definition:An organic cation that is phenothiazin-5-ium substituted by dimethylamino and amino groups at positions 3 and 7 respectively. The chloride salt is the histological dye 'azure B'.
Synonyms:related_synonym: Formula=C15H16N3S;   InChI=1S/C15H16N3S/c1-16-10-4-6-12-14(8-10)19-15-9-11(18(2)3)5-7-13(15)17-12/h4-9,16H,1-3H3/q+1;   InChIKey=VBFJMDUNUIVOMH-UHFFFAOYSA-N;   SMILES=CNc1ccc2nc3ccc(cc3[s+]c2c1)N(C)C;   azure B cation;   azure B(1+)


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azure B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein multiple interactions EXP [Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form; Azure B results in decreased expression of and affects the cleavage of APP protein CTD PMID:30500345 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
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G BACE1 beta-secretase 1 decreases activity EXP Azure B results in decreased activity of BACE1 protein CTD PMID:30500345 NCBI chr11:117,285,207...117,316,256
Ensembl chr11:117,285,207...117,316,259
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24161
    chemical entity 24127
      molecular entity 24080
        ion 17089
          organic ion 8616
            organic cation 7315
              3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium 2
                azure B 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 24161
    subatomic particle 24116
      composite particle 24116
        hadron 24116
          baryon 24116
            nucleon 24116
              atomic nucleus 24116
                atom 24116
                  main group element atom 23948
                    main group molecular entity 23948
                      p-block molecular entity 23938
                        carbon group molecular entity 23681
                          organic molecular entity 23637
                            organic ion 8616
                              organic cation 7315
                                3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium 2
                                  azure B 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.