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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium
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Accession:CHEBI:87640 term browser browse the term
Definition:An organic cation that is phenothiazin-5-ium substituted by dimethylamino and amino groups at positions 3 and 7 respectively. The chloride salt is the histological dye 'azure B'.
Synonyms:related_synonym: Formula=C15H16N3S;   InChI=1S/C15H16N3S/c1-16-10-4-6-12-14(8-10)19-15-9-11(18(2)3)5-7-13(15)17-12/h4-9,16H,1-3H3/q+1;   InChIKey=VBFJMDUNUIVOMH-UHFFFAOYSA-N;   SMILES=CNc1ccc2nc3ccc(cc3[s+]c2c1)N(C)C;   azure B cation;   azure B(1+)


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azure B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form; Azure B results in decreased expression of and affects the cleavage of APP protein CTD PMID:30500345 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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G Bace1 beta-secretase 1 decreases activity ISO Azure B results in decreased activity of BACE1 protein CTD PMID:30500345 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    chemical entity 19773
      molecular entity 19771
        ion 15935
          organic ion 8447
            organic cation 7303
              3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium 2
                azure B 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    main group molecular entity 19665
                      p-block molecular entity 19665
                        carbon group molecular entity 19583
                          organic molecular entity 19573
                            organic ion 8447
                              organic cation 7303
                                3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium 2
                                  azure B 2
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