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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hexane-2,3-dione
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Accession:CHEBI:87583 term browser browse the term
Definition:An alpha-diketone that is hexane substituted by oxo groups at positions 2 and 3 respectively.
Synonyms:related_synonym: Formula=C6H10O2;   InChI=1S/C6H10O2/c1-3-4-6(8)5(2)7/h3-4H2,1-2H3;   InChIKey=MWVFCEVNXHTDNF-UHFFFAOYSA-N;   Methyl propyl diketone;   SMILES=CCCC(=O)C(C)=O
 xref: CAS:3848-24-6;   HMDB:HMDB0031491
 xref_mesh: MESH:C043231
 xref: Reaxys:1699896


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hexane-2,3-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction ISO AKR1A1 protein results in increased reduction of 2,3-hexanedione CTD PMID:10510318 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases reduction
multiple interactions
ISO AKR1B1 protein results in increased reduction of 2,3-hexanedione
[AKR1B1 protein results in increased reduction of 2,3-hexanedione] which results in increased chemical synthesis of Hexanones
CTD PMID:10510318 PMID:23295224 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases reduction
multiple interactions
ISO AKR1B10 protein results in increased reduction of 2,3-hexanedione
[AKR1B10 protein results in increased reduction of 2,3-hexanedione] which results in increased chemical synthesis of Hexanones
CTD PMID:23295224 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of 2,3-hexanedione CTD PMID:18845131 NCBI chr 4:62,997,241...63,009,815 JBrowse link
G Cbr1 carbonyl reductase 1 increases reduction
multiple interactions
ISO CBR1 protein results in increased reduction of 2,3-hexanedione
8-prenylnaringenin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 2,3-hexanedione]; Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; isoxanthohumol inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; Quercetin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; xanthohumol inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]
CTD PMID:23295225 PMID:25541467 PMID:30849340 NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            hexane-2,3-dione 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      ketone 16924
                                        diketone 1183
                                          alpha-diketone 191
                                            hexane-2,3-dione 5
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