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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hexane-2,3-dione
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Accession:CHEBI:87583 term browser browse the term
Definition:An alpha-diketone that is hexane substituted by oxo groups at positions 2 and 3 respectively.
Synonyms:related_synonym: Formula=C6H10O2;   InChI=1S/C6H10O2/c1-3-4-6(8)5(2)7/h3-4H2,1-2H3;   InChIKey=MWVFCEVNXHTDNF-UHFFFAOYSA-N;   Methyl propyl diketone;   SMILES=CCCC(=O)C(C)=O
 xref: CAS:3848-24-6;   HMDB:HMDB0031491
 xref_mesh: MESH:C043231
 xref: Reaxys:1699896


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hexane-2,3-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction ISO AKR1A1 protein results in increased reduction of 2,3-hexanedione CTD PMID:10510318 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases reduction
multiple interactions
ISO AKR1B1 protein results in increased reduction of 2,3-hexanedione
[AKR1B1 protein results in increased reduction of 2,3-hexanedione] which results in increased chemical synthesis of Hexanones
CTD PMID:10510318, PMID:23295224 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases reduction
multiple interactions
ISO AKR1B10 protein results in increased reduction of 2,3-hexanedione
[AKR1B10 protein results in increased reduction of 2,3-hexanedione] which results in increased chemical synthesis of Hexanones
CTD PMID:23295224 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of 2,3-hexanedione CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Cbr1 carbonyl reductase 1 increases reduction
multiple interactions
ISO CBR1 protein results in increased reduction of 2,3-hexanedione
8-prenylnaringenin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 2,3-hexanedione]; Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; isoxanthohumol inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; Quercetin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; xanthohumol inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]
CTD PMID:23295225, PMID:25541467, PMID:30849340 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            hexane-2,3-dione 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        diketone 1163
                                          alpha-diketone 191
                                            hexane-2,3-dione 5
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