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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:PF-670462
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Accession:CHEBI:87236 term browser browse the term
Definition:A hydrochloride salt resulting from the formal reaction of 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine with 2 mol eq. of hydrogen chloride. It is a selective inhibitor of the delta- and epsilon-isoforms of casein kinase 1 (CK1delta and CK1epsilon).
Synonyms:exact_synonym: 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine dihydrochloride
 related_synonym: Formula=C19H22Cl2FN5;   InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H;   InChIKey=PSNKGVAXBSAHCH-UHFFFAOYSA-N;   SMILES=Cl.Cl.Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1
 xref: CAS:950912-80-8
 xref_mesh: MESH:C522839
 xref: PMID:17502429;   PMID:20407760;   PMID:21927596;   PMID:22168824;   PMID:22549116;   PMID:22743604;   PMID:22832921;   PMID:23349822;   PMID:23863866;   PMID:23936135;   PMID:24076244;   PMID:25245819;   Reaxys:11152377


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PF-670462 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tardbp TAR DNA binding protein multiple interactions ISO PF-670462 inhibits the reaction [arsenite results in increased phosphorylation of TARDBP protein] CTD PMID:29109149 NCBI chr 5:165,432,089...165,442,232
Ensembl chr 5:165,432,095...165,442,048
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  CHEBI ontology 19773
    role 19719
      biological role 19719
        biochemical role 19312
          cofactor 15551
            ammonium 8224
              ammonium ion derivative 8220
                PF-670462 free base(2+) 1
                  PF-670462 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      halogen 18102
                        chlorine atom 17924
                          chlorine molecular entity 17924
                            elemental chlorine 8458
                              monoatomic chlorine 8442
                                chloride 8442
                                  chloride salt 8442
                                    organic chloride salt 898
                                      hydrochloride 682
                                        PF-670462 1
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