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ONTOLOGY REPORT - ANNOTATIONS


Term:PF-670462
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Accession:CHEBI:87236 term browser browse the term
Definition:A hydrochloride salt resulting from the formal reaction of 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine with 2 mol eq. of hydrogen chloride. It is a selective inhibitor of the delta- and epsilon-isoforms of casein kinase 1 (CK1delta and CK1epsilon).
Synonyms:exact_synonym: 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine dihydrochloride
 related_synonym: Formula=C19H22Cl2FN5;   InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H;   InChIKey=PSNKGVAXBSAHCH-UHFFFAOYSA-N;   SMILES=Cl.Cl.Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1
 xref: CAS:950912-80-8 "ChemIDplus"
 xref_mesh: MESH:C522839
 xref: PMID:17502429 "Europe PMC";   PMID:20407760 "Europe PMC";   PMID:21927596 "Europe PMC";   PMID:22168824 "Europe PMC";   PMID:22549116 "Europe PMC";   PMID:22743604 "Europe PMC";   PMID:22832921 "Europe PMC";   PMID:23349822 "Europe PMC";   PMID:23863866 "Europe PMC";   PMID:23936135 "Europe PMC";   PMID:24076244 "Europe PMC";   PMID:25245819 "Europe PMC";   Reaxys:11152377 "Reaxys"


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PF-670462 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:6480464

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      biological role 19710
        biochemical role 19210
          cofactor 15447
            ammonium 8219
              ammonium ion derivative 8214
                PF-670462 free base(2+) 1
                  PF-670462 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    subatomic particle 19762
      composite particle 19762
        hadron 19762
          baryon 19762
            nucleon 19762
              atomic nucleus 19762
                atom 19762
                  main group element atom 19646
                    p-block element atom 19646
                      halogen 17904
                        chlorine atom 17665
                          chlorine molecular entity 17665
                            elemental chlorine 8378
                              monoatomic chlorine 8359
                                chloride 8359
                                  chloride salt 8359
                                    organic chloride salt 654
                                      hydrochloride 427
                                        PF-670462 1
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