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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:PF-670462
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Accession:CHEBI:87236 term browser browse the term
Definition:A hydrochloride salt resulting from the formal reaction of 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine with 2 mol eq. of hydrogen chloride. It is a selective inhibitor of the delta- and epsilon-isoforms of casein kinase 1 (CK1delta and CK1epsilon).
Synonyms:exact_synonym: 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine dihydrochloride
 related_synonym: Formula=C19H22Cl2FN5;   InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H;   InChIKey=PSNKGVAXBSAHCH-UHFFFAOYSA-N;   SMILES=Cl.Cl.Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1
 xref: CAS:950912-80-8
 xref_mesh: MESH:C522839
 xref: PMID:17502429;   PMID:20407760;   PMID:21927596;   PMID:22168824;   PMID:22549116;   PMID:22743604;   PMID:22832921;   PMID:23349822;   PMID:23863866;   PMID:23936135;   PMID:24076244;   PMID:25245819;   Reaxys:11152377


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PF-670462 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tardbp TAR DNA binding protein multiple interactions ISO PF-670462 inhibits the reaction [arsenite results in increased phosphorylation of TARDBP protein] CTD PMID:29109149 NCBI chr 5:165,432,089...165,442,232
Ensembl chr 5:165,432,095...165,442,048
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  CHEBI ontology 19817
    role 19767
      biological role 19767
        biochemical role 19315
          cofactor 15563
            ammonium 8225
              ammonium ion derivative 8221
                PF-670462 free base(2+) 1
                  PF-670462 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19817
    subatomic particle 19815
      composite particle 19815
        hadron 19815
          baryon 19815
            nucleon 19815
              atomic nucleus 19815
                atom 19815
                  main group element atom 19705
                    p-block element atom 19705
                      halogen 18126
                        chlorine atom 17941
                          chlorine molecular entity 17941
                            elemental chlorine 8461
                              monoatomic chlorine 8444
                                chloride 8444
                                  chloride salt 8444
                                    organic chloride salt 884
                                      hydrochloride 674
                                        PF-670462 1
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