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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrimidine antifungal agent
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Accession:CHEBI:87204 term browser browse the term
Definition:A member of the class of pyrimidines that has significant antifungal properties.
Synonyms:related_synonym: pyrimidine antifungal agents


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bupirimate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP bupirimate results in increased activity of NR1I2 protein CTD PMID:16565514, PMID:21924250 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP bupirimate results in increased activity of NR1I3 protein CTD PMID:21924250 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302
JBrowse link
cyprodinil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions
increases activity
decreases expression
affects localization
EXP
ISO
cyprodinil binds to and results in increased activity of AHR protein
cyprodinil results in increased activity of AHR protein
cyprodinil results in decreased expression of AHR protein
AHR protein affects the reaction [cyprodinil results in increased expression of CYP1A1 protein]
cyprodinil affects the localization of AHR protein
CTD PMID:23228475, PMID:23436777, PMID:28728110 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AIF1 allograft inflammatory factor 1 multiple interactions ISO
EXP
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of AIF1 protein
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of AIF1 protein]
CTD PMID:31939705 NCBI chr 6:31,615,212...31,617,015
Ensembl chr 6:31,615,217...31,617,021
JBrowse link
G APP amyloid beta precursor protein affects binding
multiple interactions
EXP cyprodinil binds to APP protein modified form
[APP gene mutant form results in increased expression of APP protein modified form] which results in increased susceptibility to cyprodinil; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of AIF1 protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of GFAP protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL1B protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL6 protein]; APP protein modified form results in increased susceptibility to [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil]
CTD PMID:31939705 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G AR androgen receptor affects binding
increases activity
multiple interactions
increases expression
EXP cyprodinil binds to AR protein
cyprodinil results in increased activity of AR protein
cyprodinil inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; cyprodinil inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]
cyprodinil results in increased expression of AR mRNA
CTD PMID:21310686, PMID:23436777, PMID:28728110, PMID:28803809 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator multiple interactions ISO ARNT protein affects the reaction [cyprodinil results in increased expression of CYP1A1 protein] CTD PMID:23228475 NCBI chr 1:150,809,713...150,876,737
Ensembl chr 1:150,809,713...150,876,708
JBrowse link
G BACE1 beta-secretase 1 multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of BACE1 protein CTD PMID:31939705 NCBI chr11:117,285,207...117,316,256
Ensembl chr11:117,285,207...117,316,259
JBrowse link
G CASP3 caspase 3 increases expression
multiple interactions
EXP cyprodinil results in increased expression of CASP3 mRNA
[pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of CASP3 mRNA
CTD PMID:22880100 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCND1 cyclin D1 multiple interactions
increases expression
EXP fulvestrant inhibits the reaction [cyprodinil results in increased expression of CCND1 protein] CTD PMID:26344002 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNE1 cyclin E1 increases expression
multiple interactions
EXP cyprodinil results in increased expression of CCNE1 protein
fulvestrant inhibits the reaction [cyprodinil results in increased expression of CCNE1 protein]
CTD PMID:26344002 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CTSD cathepsin D increases expression
multiple interactions
EXP cyprodinil results in increased expression of CTSD protein
fulvestrant inhibits the reaction [cyprodinil results in increased expression of CTSD protein]
CTD PMID:26344002 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,755...1,764,573
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
EXP
ISO
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [cyprodinil results in increased expression of CYP1A1 protein]; Dexamethasone inhibits the reaction [cyprodinil results in increased expression of CYP1A1 protein]
cyprodinil results in increased expression of CYP1A1 mRNA; cyprodinil results in increased expression of CYP1A1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [cyprodinil results in increased expression of CYP1A1 mRNA]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [cyprodinil results in increased expression of CYP1A1 protein]; AHR protein affects the reaction [cyprodinil results in increased expression of CYP1A1 protein]; ARNT protein affects the reaction [cyprodinil results in increased expression of CYP1A1 protein]
CTD PMID:23228475 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G ESR1 estrogen receptor 1 affects binding EXP cyprodinil binds to ESR1 protein CTD PMID:27999363 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions EXP
ISO
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of GFAP protein]
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of GFAP protein
CTD PMID:31939705 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GPX1 glutathione peroxidase 1 affects expression
multiple interactions
EXP cyprodinil affects the expression of GPX1 mRNA
[pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of GPX1 mRNA
CTD PMID:22880100 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G H2AX H2A.X variant histone increases phosphorylation
multiple interactions
EXP cyprodinil results in increased phosphorylation of H2AX protein
[fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein
CTD PMID:22389207 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL1B protein] CTD PMID:31939705 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions EXP [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL6 protein] CTD PMID:31939705 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation ISO
EXP
cyprodinil results in increased phosphorylation of MAPK1 protein CTD PMID:23228475 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation ISO
EXP
cyprodinil results in increased phosphorylation of MAPK3 protein CTD PMID:23228475 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions
increases activity
EXP [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased activity of NR1I2 protein
cyprodinil results in increased activity of NR1I2 protein
CTD PMID:25028461, PMID:28728110 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G PCNA proliferating cell nuclear antigen increases expression EXP cyprodinil results in increased expression of PCNA protein CTD PMID:26344002 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [cyprodinil binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
fenarimol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 decreases expression ISO fenarimol results in decreased expression of ABCA1 mRNA CTD PMID:28970091 NCBI chr 9:104,781,006...104,928,232
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G AR androgen receptor affects binding
multiple interactions
EXP fenarimol binds to AR protein
Dihydrotestosterone inhibits the reaction [fenarimol results in increased activity of AR protein]; fenarimol inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; fenarimol inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD PMID:15064155, PMID:15253041, PMID:18324785, PMID:26602169 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 increases expression ISO fenarimol results in increased expression of CYP17A1 mRNA; fenarimol results in increased expression of CYP17A1 protein CTD PMID:21722721 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 decreases activity
increases expression
EXP
ISO
fenarimol results in decreased activity of CYP19A1 protein
fenarimol results in increased expression of CYP19A1 mRNA; fenarimol results in increased expression of CYP19A1 protein
CTD PMID:10806373, PMID:11884232, PMID:12127262, PMID:16996190, PMID:21722721 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP1A1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A1 protein; [fenarimol co-treated with vinclozolin] affects the expression of CYP1A1 protein CTD PMID:17686559 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP1A2 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A2 protein; [fenarimol co-treated with vinclozolin] affects the expression of CYP1A2 protein CTD PMID:17686559 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 increases expression ISO fenarimol results in increased expression of CYP26A1 mRNA CTD PMID:28970091 NCBI chr10:93,073,475...93,077,885
Ensembl chr10:93,073,475...93,077,885
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP2B1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2B1 protein; [fenarimol co-treated with vinclozolin] affects the expression of CYP2B1 protein CTD PMID:17686559 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP2E1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2E1 protein; [fenarimol co-treated with vinclozolin] affects the expression of CYP2E1 protein CTD PMID:17686559 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 increases expression ISO fenarimol results in increased expression of CYP51 mRNA CTD PMID:28970091, PMID:29337257 NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,112,153...92,134,803
JBrowse link
G DHCR7 7-dehydrocholesterol reductase increases expression ISO fenarimol results in increased expression of DHCR7 mRNA CTD PMID:28970091 NCBI chr11:71,434,411...71,448,393
Ensembl chr11:71,428,193...71,452,868
JBrowse link
G DHRS3 dehydrogenase/reductase 3 increases expression ISO fenarimol results in increased expression of DHRS3 mRNA CTD PMID:28970091 NCBI chr 1:12,567,910...12,618,210
Ensembl chr 1:12,567,910...12,618,210
JBrowse link
G DUSP5 dual specificity phosphatase 5 increases expression ISO fenarimol results in increased expression of DUSP5 mRNA CTD PMID:28970091 NCBI chr10:110,497,907...110,511,533
Ensembl chr10:110,497,907...110,511,533
JBrowse link
G ESR1 estrogen receptor 1 affects binding
increases activity
multiple interactions
decreases expression
EXP fenarimol binds to ESR1 protein
fenarimol results in increased activity of ESR1 protein
[Chlorpyrifos co-treated with fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein; afimoxifene inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [fenarimol results in increased activity of ESR1 protein]; fenarimol binds to and results in increased activity of ESR1 protein; fenarimol promotes the reaction [Estradiol results in increased activity of ESR1 protein]; fulvestrant inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein]; fulvestrant inhibits the reaction [fenarimol results in increased activity of ESR1 protein]
fenarimol results in decreased expression of ESR1 mRNA
CTD PMID:10789375, PMID:15064155, PMID:15253041, PMID:15261991, PMID:16626760, PMID:20143881, PMID:26812056, PMID:29162470 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 multiple interactions
increases activity
increases expression
EXP
ISO
fenarimol promotes the reaction [Estradiol results in increased expression of ESR2 mRNA]
fenarimol results in increased activity of ESR2 protein
fenarimol results in increased expression of ESR2 mRNA
CTD PMID:15064155, PMID:15261991, PMID:21722721, PMID:26812056 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G FDFT1 farnesyl-diphosphate farnesyltransferase 1 increases expression ISO fenarimol results in increased expression of FDFT1 mRNA CTD PMID:28970091 NCBI chr 8:11,795,582...11,839,309
Ensembl chr 8:11,795,573...11,839,304
JBrowse link
G FSHB follicle stimulating hormone subunit beta increases expression ISO fenarimol results in increased expression of FSHB protein CTD PMID:16324804 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,016...30,235,261
JBrowse link
G GBX2 gastrulation brain homeobox 2 increases expression ISO fenarimol results in increased expression of GBX2 mRNA CTD PMID:28970091 NCBI chr 2:236,165,236...236,168,386
Ensembl chr 2:236,165,236...236,168,386
JBrowse link
G GGT1 gamma-glutamyltransferase 1 increases activity ISO fenarimol results in increased activity of GGT1 protein CTD PMID:2387028 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,556,007...24,628,987
Ensembl chr22:24,556,007...24,628,987
Ensembl chr22:24,556,007...24,628,987
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO fenarimol results in increased expression of HMGCR mRNA CTD PMID:28970091 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,362,101
JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO fenarimol results in increased expression of HMGCS1 mRNA CTD PMID:28970091 NCBI chr 5:43,287,470...43,313,477
Ensembl chr 5:43,287,470...43,313,512
JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 increases expression ISO fenarimol results in increased expression of HSD3B1 mRNA CTD PMID:21722721 NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054
JBrowse link
G IFRD1 interferon related developmental regulator 1 decreases expression ISO fenarimol results in decreased expression of IFRD1 mRNA CTD PMID:28970091 NCBI chr 7:112,423,174...112,477,203
Ensembl chr 7:112,422,887...112,481,017
Ensembl chr 7:112,422,887...112,481,017
JBrowse link
G IGF1 insulin like growth factor 1 decreases expression ISO fenarimol results in decreased expression of IGF1 mRNA CTD PMID:15590119 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G LHX1 LIM homeobox 1 increases expression ISO fenarimol results in increased expression of LHX1 mRNA CTD PMID:28970091 NCBI chr17:36,937,475...36,944,612
Ensembl chr17:36,936,785...36,944,612
JBrowse link
G LRRC75A leucine rich repeat containing 75A increases expression ISO fenarimol results in increased expression of LRRC75A mRNA CTD PMID:28970091 NCBI chr17:16,441,577...16,492,193
Ensembl chr17:16,441,577...16,492,193
JBrowse link
G LTF lactotransferrin decreases expression ISO fenarimol results in decreased expression of LTF mRNA CTD PMID:16324804 NCBI chr 3:46,435,645...46,485,234
Ensembl chr 3:46,435,645...46,485,234
JBrowse link
G MSMO1 methylsterol monooxygenase 1 increases expression ISO fenarimol results in increased expression of MSMO1 mRNA CTD PMID:28970091 NCBI chr 4:165,327,669...165,343,164
Ensembl chr 4:165,327,667...165,343,164
JBrowse link
G NGFR nerve growth factor receptor increases expression ISO fenarimol results in increased expression of NGFR mRNA CTD PMID:28970091 NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008
JBrowse link
G NOBOX NOBOX oogenesis homeobox increases expression ISO fenarimol results in increased expression of NOBOX mRNA; fenarimol results in increased expression of NOBOX protein CTD PMID:21722721 NCBI chr 7:144,396,805...144,410,422
Ensembl chr 7:144,397,240...144,410,227
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity
multiple interactions
EXP
ISO
fenarimol results in increased activity of NR1I2 protein
fenarimol binds to and results in increased activity of NR1I2 protein
CTD PMID:16565514, PMID:21115097 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G NSDHL NAD(P) dependent steroid dehydrogenase-like increases expression ISO fenarimol results in increased expression of NSDHL mRNA CTD PMID:28970091 NCBI chr  X:152,831,001...152,869,729
Ensembl chr  X:152,830,967...152,869,729
JBrowse link
G ODC1 ornithine decarboxylase 1 decreases expression ISO fenarimol results in decreased expression of ODC1 mRNA CTD PMID:15590119 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G RARB retinoic acid receptor beta increases expression ISO fenarimol results in increased expression of RARB mRNA CTD PMID:28970091 NCBI chr 3:24,829,321...25,597,932
Ensembl chr 3:25,174,332...25,597,932
JBrowse link
G RASD1 ras related dexamethasone induced 1 increases expression ISO fenarimol results in increased expression of RASD1 mRNA CTD PMID:28970091 NCBI chr17:17,494,437...17,496,395
Ensembl chr17:17,494,437...17,496,395
JBrowse link
G SC5D sterol-C5-desaturase increases expression ISO fenarimol results in increased expression of SC5D mRNA CTD PMID:28970091 NCBI chr11:121,292,771...121,313,410
Ensembl chr11:121,292,681...121,313,410
JBrowse link
G SCD stearoyl-CoA desaturase increases expression ISO fenarimol results in increased expression of SCD1 mRNA CTD PMID:28970091 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
JBrowse link
G SCGB2A2 secretoglobin family 2A member 2 decreases expression ISO fenarimol results in decreased expression of SCGB2A2 mRNA CTD PMID:15590119 NCBI chr11:62,270,130...62,273,160
Ensembl chr11:62,270,158...62,273,160
JBrowse link
G SCUBE1 signal peptide, CUB domain and EGF like domain containing 1 increases expression ISO fenarimol results in increased expression of SCUBE1 mRNA CTD PMID:28970091 NCBI chr22:43,197,280...43,343,372
Ensembl chr22:43,197,280...43,343,372
JBrowse link
G SRD5A2 steroid 5 alpha-reductase 2 decreases activity EXP fenarimol results in decreased activity of SRD5A2 protein CTD PMID:17218080 NCBI chr 2:31,522,480...31,665,651
Ensembl chr 2:31,522,480...31,580,938
JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 increases expression ISO fenarimol results in increased expression of SREBF2 mRNA CTD PMID:28970091 NCBI chr22:41,833,105...41,907,308
Ensembl chr22:41,833,079...41,907,307
JBrowse link
G ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 increases expression ISO fenarimol results in increased expression of ST3GAL3 mRNA CTD PMID:28970091 NCBI chr 1:43,707,465...43,931,164
Ensembl chr 1:43,705,824...43,931,165
JBrowse link
G STAMBPL1 STAM binding protein like 1 increases expression ISO fenarimol results in increased expression of STAMBPL1 mRNA CTD PMID:28970091 NCBI chr10:88,879,368...88,923,502
Ensembl chr10:88,879,734...88,975,153
JBrowse link
G TRDMT1 tRNA aspartic acid methyltransferase 1 decreases expression ISO fenarimol results in decreased expression of TRDMT1 mRNA CTD PMID:28970091 NCBI chr10:17,137,336...17,202,066
Ensembl chr10:17,137,336...17,202,054
JBrowse link
G ZNF496 zinc finger protein 496 increases expression ISO fenarimol results in increased expression of ZFP496 mRNA CTD PMID:28970091 NCBI chr 1:247,297,415...247,331,867
Ensembl chr 1:247,297,412...247,331,846
JBrowse link
G ZNF703 zinc finger protein 703 increases expression ISO fenarimol results in increased expression of ZFP703 mRNA CTD PMID:28970091 NCBI chr 8:37,695,782...37,700,019
Ensembl chr 8:37,695,782...37,700,019
JBrowse link
flucytosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator decreases expression EXP Flucytosine results in decreased expression of BCL2 protein CTD PMID:15592511 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G MDM2 MDM2 proto-oncogene increases expression EXP Flucytosine results in increased expression of MDM2 protein CTD PMID:15592511 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,850,686
JBrowse link
G TP53 tumor protein p53 increases expression EXP Flucytosine results in increased expression of TP53 protein CTD PMID:15592511 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
mepanipyrim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP mepanipyrim binds to and results in increased activity of AHR protein CTD PMID:23436777 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AIF1 allograft inflammatory factor 1 multiple interactions EXP
ISO
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of AIF1 protein]
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of AIF1 protein
CTD PMID:31939705 NCBI chr 6:31,615,212...31,617,015
Ensembl chr 6:31,615,217...31,617,021
JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP [APP gene mutant form results in increased expression of APP protein modified form] which results in increased susceptibility to mepanipyrim; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of AIF1 protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of GFAP protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL1B protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL6 protein]; APP protein modified form results in increased susceptibility to [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] CTD PMID:31939705 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G BACE1 beta-secretase 1 multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of BACE1 protein CTD PMID:31939705 NCBI chr11:117,285,207...117,316,256
Ensembl chr11:117,285,207...117,316,259
JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions ISO
EXP
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of GFAP protein
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of GFAP protein]
CTD PMID:31939705 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL1B protein] CTD PMID:31939705 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions EXP [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL6 protein] CTD PMID:31939705 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
nuarimol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing affects binding EXP nuarimol binds to ADIPOQ protein CTD PMID:32278787 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G ESR2 estrogen receptor 2 affects binding EXP nuarimol binds to ESR2 protein CTD PMID:32278787 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
pyrimethanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP pyrimethanil binds to and results in increased activity of AHR protein CTD PMID:23436777 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AIF1 allograft inflammatory factor 1 multiple interactions ISO
EXP
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of AIF1 protein
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of AIF1 protein]
CTD PMID:31939705 NCBI chr 6:31,615,212...31,617,015
Ensembl chr 6:31,615,217...31,617,021
JBrowse link
G APP amyloid beta precursor protein multiple interactions
affects binding
EXP [APP gene mutant form results in increased expression of APP protein modified form] which results in increased susceptibility to pyrimethanil; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of AIF1 protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of GFAP protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL1B protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL6 protein]; APP protein modified form results in increased susceptibility to [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil]
pyrimethanil binds to APP protein modified form
CTD PMID:31939705 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G AR androgen receptor increases expression
multiple interactions
EXP pyrimethanil results in increased expression of AR mRNA
pyrimethanil inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]
CTD PMID:21310686 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G BACE1 beta-secretase 1 multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of BACE1 protein CTD PMID:31939705 NCBI chr11:117,285,207...117,316,256
Ensembl chr11:117,285,207...117,316,259
JBrowse link
G CASP3 caspase 3 multiple interactions
affects expression
EXP [pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of CASP3 mRNA
pyrimethanil affects the expression of CASP3 mRNA
CTD PMID:22880100 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions EXP
ISO
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of GFAP protein]
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of GFAP protein
CTD PMID:31939705 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GPX1 glutathione peroxidase 1 affects expression
multiple interactions
EXP pyrimethanil affects the expression of GPX1 mRNA
[pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of GPX1 mRNA
CTD PMID:22880100 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL1B protein] CTD PMID:31939705 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions EXP [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL6 protein] CTD PMID:31939705 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions EXP [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [pyrimethanil binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24359
    role 24266
      biological role 24233
        antimicrobial agent 20494
          antifungal agent 17040
            pyrimidine antifungal agent 70
              pyrimidine antifungal drug + 3
              pyrimidine fungicide + 67
Path 2
Term Annotations click to browse term
  CHEBI ontology 24359
    subatomic particle 24315
      composite particle 24315
        hadron 24315
          baryon 24315
            nucleon 24315
              atomic nucleus 24315
                atom 24315
                  main group element atom 24160
                    p-block element atom 24160
                      carbon group element atom 23936
                        carbon atom 23892
                          organic molecular entity 23892
                            organic molecule 23769
                              organic cyclic compound 23036
                                organic heterocyclic compound 21142
                                  organic heteromonocyclic compound 17419
                                    diazines 12254
                                      pyrimidines 12048
                                        pyrimidine antifungal agent 70
                                          pyrimidine antifungal drug + 3
                                          pyrimidine fungicide + 67
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.