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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:STAT3 inhibitor
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Accession:CHEBI:87183 term browser browse the term
Definition:An inhibitor of signal transducer and activator of transcription 3 (STAT3)
Synonyms:related_synonym: STAT3 inhibitors;   signal transducer and activator of transcription 3 inhibitor;   signal transducer and activator of transcription 3 inhibitors
 xref: Wikipedia:STAT3



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niclosamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO Niclosamide results in decreased expression of ACACA mRNA CTD PMID:22576131 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]
CTD PMID:26792726 PMID:28824321 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Niclosamide results in decreased expression of ACSL1 mRNA CTD PMID:22576131 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ACTA2 protein]
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of ACTA2 protein]
CTD PMID:26643609 PMID:28318631 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide decreases expression ISO Niclosamide results in decreased expression of ADH4 mRNA CTD PMID:28284560 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
JBrowse link
G Afp alpha-fetoprotein multiple interactions EXP Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]] CTD PMID:32961231 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases cleavage ISO Niclosamide results in increased cleavage of AIFM1 protein CTD PMID:22576131 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
multiple interactions
ISO Niclosamide results in increased expression of AKT1 mRNA
Niclosamide inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein]
CTD PMID:20215516 PMID:26792726 PMID:29843133 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Niclosamide results in decreased expression of ALDH1A1 protein CTD PMID:24736023 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldob aldolase, fructose-bisphosphate B increases expression ISO Niclosamide results in increased expression of ALDOB mRNA CTD PMID:22576131 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO Niclosamide results in decreased expression of ALDOC mRNA CTD PMID:22576131 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type increases expression
multiple interactions
decreases response to substance
ISO Niclosamide results in increased expression of ALOX12B mRNA
TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]
ALOX12B protein results in decreased susceptibility to Niclosamide
CTD PMID:30258081 NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
decreases response to substance
increases expression
ISO TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]
ALOX5 protein results in decreased susceptibility to Niclosamide
CTD PMID:30258081 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases expression ISO Niclosamide results in decreased expression of ALPL mRNA CTD PMID:28824321 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Apof apolipoprotein F decreases expression ISO Niclosamide results in decreased expression of APOF mRNA CTD PMID:28284560 NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
ISO [enzalutamide co-treated with Niclosamide] results in decreased expression of AR protein; [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]] which results in decreased expression of KLK3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein]; Niclosamide inhibits the reaction [AR protein alternative form binds to KLK3 promoter]; Niclosamide inhibits the reaction [AR protein alternative form results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 protein]; Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]; Niclosamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form
Niclosamide results in decreased expression of AR protein; Niclosamide results in decreased expression of AR protein alternative form
CTD PMID:24740322 PMID:25970160 PMID:28500234 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase decreases expression ISO Niclosamide analog results in decreased expression of ARAF protein; Niclosamide results in decreased expression of ARAF protein CTD PMID:28284560 NCBI chr  X:1,227,392...1,292,356
Ensembl chr  X:1,227,392...1,239,073
JBrowse link
G Asf1b anti-silencing function 1B histone chaperone decreases expression ISO Niclosamide results in decreased expression of ASF1B mRNA CTD PMID:28284560 NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549
JBrowse link
G Atf3 activating transcription factor 3 increases expression
multiple interactions
ISO Niclosamide results in increased expression of ATF3 mRNA; Niclosamide results in increased expression of ATF3 protein
ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]; ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]
CTD PMID:26917416 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Niclosamide results in increased expression of ATF4 mRNA; Niclosamide results in increased expression of ATF4 protein CTD PMID:26917416 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression ISO Niclosamide results in increased expression of ATP5F1A mRNA CTD PMID:22576131 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp5f1d ATP synthase F1 subunit delta increases expression ISO Niclosamide results in increased expression of ATP5F1D mRNA CTD PMID:22576131 NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929
JBrowse link
G Atp5mc3 ATP synthase membrane subunit c locus 3 decreases expression ISO Niclosamide results in decreased expression of ATP5MC3 mRNA CTD PMID:22576131 NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279
JBrowse link
G Atp5mf ATP synthase membrane subunit f decreases expression ISO Niclosamide results in decreased expression of ATP5MF mRNA CTD PMID:22576131 NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236
JBrowse link
G Atp5mg ATP synthase membrane subunit g decreases expression ISO Niclosamide results in decreased expression of ATP5MG mRNA CTD PMID:22576131 NCBI chr 8:45,226,750...45,233,582
Ensembl chr 8:45,225,686...45,233,559
JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b decreases expression ISO Niclosamide results in decreased expression of ATP5PB mRNA CTD PMID:22576131 NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418
JBrowse link
G Atp6ap1 ATPase H+ transporting accessory protein 1 decreases expression ISO Niclosamide results in decreased expression of ATP6AP1 mRNA CTD PMID:22576131 NCBI chr  X:152,079,954...152,087,034
Ensembl chr  X:152,079,865...152,087,034
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA] CTD PMID:26792726 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
JBrowse link
G Aurkb aurora kinase B decreases expression ISO Niclosamide results in decreased expression of AURKB mRNA CTD PMID:28284560 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Axin2 axin 2 multiple interactions
decreases expression
ISO Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA]
Niclosamide results in decreased expression of AXIN2 mRNA; Niclosamide results in decreased expression of AXIN2 protein
CTD PMID:22576131 PMID:24534281 PMID:24552774 PMID:24736023 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO [Niclosamide binds to Polyethyleneimine] which results in increased expression of BAD mRNA CTD PMID:25988281 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [Niclosamide binds to Polyethyleneimine] which results in increased expression of BAK1 mRNA CTD PMID:25988281 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
decreases expression
ISO Niclosamide results in increased expression of BAX protein
[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAX mRNA; [Niclosamide co-treated with bicalutamide] results in increased expression of BAX protein; bicalutamide inhibits the reaction [Niclosamide results in decreased expression of BAX protein]
CTD PMID:25634333 PMID:25988281 PMID:26703449 PMID:28500234 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression
ISO TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of BBC3 mRNA] CTD PMID:30258081 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Niclosamide analog results in decreased expression of BCL2 protein; Niclosamide results in decreased expression of BCL2 protein
[Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2 mRNA; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2 protein]
CTD PMID:20215516 PMID:23894143 PMID:25634333 PMID:25988281 PMID:26116531 More... NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO [Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2L1 mRNA; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2L1 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2L1 protein]
Niclosamide analog results in decreased expression of BCL2L1 protein; Niclosamide results in decreased expression of BCL2L1 protein
CTD PMID:20215516 PMID:25988281 PMID:26116531 PMID:28284560 PMID:28500234 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l2 Bcl2-like 2 decreases expression
multiple interactions
ISO Niclosamide results in decreased expression of BCL2L2 protein
[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]
CTD PMID:23894143 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
JBrowse link
G Bcl6 BCL6, transcription repressor multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein] CTD PMID:33632240 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Bcl9 BCL9, transcription coactivator decreases expression EXP Niclosamide results in decreased expression of BCL9 mRNA CTD PMID:27338550 NCBI chr 2:184,760,616...184,846,261
Ensembl chr 2:184,760,618...184,786,435
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
affects expression
decreases expression
ISO enzalutamide promotes the reaction [Niclosamide results in decreased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein]
Niclosamide affects the expression of BIRC5 protein
Niclosamide analog results in decreased expression of BIRC5 protein; Niclosamide results in decreased expression of BIRC5 protein
CTD PMID:24552774 PMID:24736023 PMID:25970160 PMID:28284560 PMID:28500234 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression
decreases phosphorylation
ISO Niclosamide analog results in decreased expression of BRAF protein; Niclosamide results in decreased expression of BRAF protein
Niclosamide analog results in decreased phosphorylation of BRAF protein
CTD PMID:28284560 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Casp1 caspase 1 multiple interactions ISO [Niclosamide co-treated with Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CASP1 protein
Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein]
CTD PMID:33524445 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases expression
decreases expression
ISO
EXP
Niclosamide results in increased cleavage of CASP3 protein
Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]]
[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased expression of CASP3 protein modified form; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]
Niclosamide results in increased expression of CASP3 protein modified form
Niclosamide results in decreased expression of CASP3 protein
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; [Niclosamide binds to Polyethyleneimine] which results in increased expression of CASP3 mRNA; ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP3 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]
CTD PMID:20215516 PMID:21871175 PMID:24750999 PMID:25174399 PMID:25634333 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions
increases expression
ISO bicalutamide promotes the reaction [Niclosamide results in increased expression of CASP7 protein modified form] CTD PMID:26116531 PMID:28500234 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases cleavage
ISO TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein]
Niclosamide results in increased expression of CASP9 protein modified form
CTD PMID:26116531 PMID:26703449 PMID:30258081 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL2 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA]
CTD PMID:24561310 PMID:28318631 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions ISO
EXP
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL20 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL20 mRNA]
CTD PMID:28318631 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] CTD PMID:24561310 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL5 protein] CTD PMID:24561310 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Niclosamide results in decreased expression of CCNB1 mRNA CTD PMID:28284560 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
EXP
ISO
Niclosamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]]
Niclosamide results in decreased expression of CCND1 mRNA
Niclosamide analog results in decreased expression of CCND1 protein; Niclosamide results in decreased expression of CCND1 mRNA; Niclosamide results in decreased expression of CCND1 protein
Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of CCND1 protein]
CTD PMID:19160421 PMID:20215516 PMID:24552774 PMID:24736023 PMID:26297436 More... NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 decreases expression
increases expression
ISO Niclosamide results in decreased expression of CCND2 mRNA
Niclosamide results in increased expression of CCND2 mRNA
CTD PMID:22576131 PMID:27226553 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Niclosamide results in decreased expression of CCND3 mRNA CTD PMID:22576131 PMID:27226553 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne2 cyclin E2 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA] CTD PMID:27542212 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA] CTD PMID:27542212 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD40 protein] CTD PMID:24561310 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD80 protein] CTD PMID:24561310 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD86 protein] CTD PMID:24561310 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone multiple interactions ISO CDC37 protein binds to and results in increased susceptibility to Niclosamide analog CTD PMID:28284560 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
JBrowse link
G Cdc42 cell division cycle 42 decreases expression
decreases phosphorylation
ISO Niclosamide results in decreased expression of CDC42 mRNA
Niclosamide results in decreased phosphorylation of CDC42 protein
CTD PMID:29251334 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO Niclosamide results in decreased expression of CDC6 mRNA CTD PMID:28284560 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
JBrowse link
G Cdca2 cell division cycle associated 2 decreases expression ISO Niclosamide results in decreased expression of CDCA2 mRNA CTD PMID:28284560 NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611
JBrowse link
G Cdca5 cell division cycle associated 5 decreases expression ISO Niclosamide results in decreased expression of CDCA5 mRNA CTD PMID:28284560 NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023
JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression ISO Niclosamide results in decreased expression of CDCA8 mRNA CTD PMID:28284560 NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in decreased expression of CDH1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein]
Niclosamide results in increased expression of CDH1 mRNA; Niclosamide results in increased expression of CDH1 protein
CTD PMID:25174399 PMID:26643609 PMID:30143678 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of CDH2 protein] CTD PMID:26643609 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Niclosamide results in decreased expression of CDK2 protein CTD PMID:29031202 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Niclosamide results in decreased expression of CDK4 protein CTD PMID:29031202 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA] CTD PMID:30258081 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO Niclosamide results in decreased expression of CDKN3 mRNA CTD PMID:28284560 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
JBrowse link
G Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 increases expression ISO Niclosamide results in increased expression of CELSR3 mRNA CTD PMID:28284560 NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354
JBrowse link
G Cenpa centromere protein A decreases expression ISO Niclosamide results in decreased expression of CENPA mRNA CTD PMID:28284560 NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
JBrowse link
G Cfp complement factor properdin increases expression ISO Niclosamide results in increased expression of CFP mRNA CTD PMID:28284560 NCBI chr  X:1,162,014...1,167,576
Ensembl chr  X:1,161,979...1,167,573
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Niclosamide results in decreased phosphorylation of and affects the localization of CHUK protein CTD PMID:26116531 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO Niclosamide results in decreased expression of COL1A1 mRNA CTD PMID:28824321 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Colec10 collectin subfamily member 10 increases expression ISO Niclosamide results in increased expression of COLEC10 mRNA CTD PMID:28284560 NCBI chr 7:85,744,895...85,806,368
Ensembl chr 7:85,744,895...85,805,675
JBrowse link
G Crebbp CREB binding protein increases expression ISO Niclosamide results in increased expression of CREBBP mRNA CTD PMID:22576131 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein] CTD PMID:28824321 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA] CTD PMID:27542212 NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319
JBrowse link
G Csnk1e casein kinase 1, epsilon increases expression ISO Niclosamide results in increased expression of CSNK1E mRNA CTD PMID:22576131 NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794
JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 increases expression ISO Niclosamide results in increased expression of CSRNP1 mRNA CTD PMID:28284560 NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
JBrowse link
G Ctbp1 C-terminal binding protein 1 increases expression ISO Niclosamide results in increased expression of CTBP1 mRNA CTD PMID:22576131 NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
decreases expression
increases ubiquitination
decreases activity
multiple interactions
ISO
EXP
Niclosamide results in increased expression of CTNNB1 mRNA
Niclosamide results in decreased expression of CTNNB1 mRNA
Niclosamide results in increased ubiquitination of CTNNB1 protein
Niclosamide results in decreased activity of CTNNB1 protein
Niclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]]
Niclosamide analog results in decreased expression of CTNNB1 protein; Niclosamide results in decreased expression of CTNNB1 protein
Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of CTNNB1 protein]; Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; Niclosamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of CTNNB1 protein]
CTD PMID:19772353 PMID:21531761 PMID:22576131 PMID:24534281 PMID:24552774 More... NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 multiple interactions ISO Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein] CTD PMID:24534281 NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939
JBrowse link
G Ctsc cathepsin C decreases expression ISO Niclosamide results in decreased expression of CTSC protein CTD PMID:29480568 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Ctsd cathepsin D decreases expression ISO Niclosamide results in decreased expression of CTSD protein CTD PMID:29480568 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctsk cathepsin K multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:26792726 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Cxcr5 C-X-C motif chemokine receptor 5 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA] CTD PMID:33632240 NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Niclosamide results in increased expression of CYCS protein CTD PMID:26703449 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity ISO Niclosamide results in increased activity of CYP1A1 protein CTD PMID:12451431 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases expression
ISO Niclosamide results in decreased activity of CYP1A2 protein
Niclosamide results in increased expression of CYP1A2 mRNA
CTD PMID:11124226 PMID:28284560 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Niclosamide results in decreased activity of CYP2D6 protein CTD PMID:11124226 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 increases expression ISO Niclosamide results in increased expression of CYP39A1 mRNA CTD PMID:28284560 NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Niclosamide results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Niclosamide results in increased expression of DDIT3 mRNA; Niclosamide results in increased expression of DDIT3 protein
ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]
CTD PMID:26917416 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 decreases expression ISO Niclosamide results in decreased expression of DECR1 mRNA CTD PMID:22576131 NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
JBrowse link
G Dmac2l distal membrane arm assembly component 2 like decreases expression ISO Niclosamide results in decreased expression of DMAC2L mRNA CTD PMID:22576131 NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933
JBrowse link
G Dscc1 DNA replication and sister chromatid cohesion 1 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA] CTD PMID:27542212 NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212
JBrowse link
G Dvl1 dishevelled segment polarity protein 1 increases expression ISO Niclosamide results in increased expression of DVL1 mRNA CTD PMID:22576131 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
JBrowse link
G Dvl2 dishevelled segment polarity protein 2 decreases expression
multiple interactions
ISO
EXP
Niclosamide results in decreased expression of DVL2 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]]
CTD PMID:19772353 PMID:21531761 PMID:30143678 PMID:32961231 NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820
JBrowse link
G Dvl3 dishevelled segment polarity protein 3 increases expression ISO Niclosamide results in increased expression of DVL3 mRNA CTD PMID:22576131 NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Niclosamide results in decreased expression of E2F1 mRNA CTD PMID:29843133 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G E2f8 E2F transcription factor 8 decreases expression ISO Niclosamide results in decreased expression of E2F8 mRNA CTD PMID:28284560 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
JBrowse link
G Ebf1 EBF transcription factor 1 decreases expression ISO Niclosamide results in decreased expression of EBF1 mRNA CTD PMID:27226553 NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665
JBrowse link
G Echdc1 ethylmalonyl-CoA decarboxylase 1 decreases expression ISO Niclosamide results in decreased expression of ECHDC1 mRNA CTD PMID:22576131 NCBI chr 1:28,476,354...28,507,173
Ensembl chr 1:28,476,200...28,507,319
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 decreases expression ISO Niclosamide results in decreased expression of ECHS1 mRNA CTD PMID:22576131 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
JBrowse link
G Egf epidermal growth factor decreases expression
multiple interactions
ISO Niclosamide results in decreased expression of EGF mRNA; Niclosamide results in decreased expression of EGF protein
Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]
CTD PMID:30779072 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor decreases expression
decreases phosphorylation
ISO Niclosamide analog results in decreased expression of EGFR protein; Niclosamide results in decreased expression of EGFR mRNA; Niclosamide results in decreased expression of EGFR protein
Niclosamide results in decreased phosphorylation of EGFR protein
CTD PMID:28284560 PMID:28426875 PMID:30779072 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 increases expression ISO Niclosamide results in increased expression of EGR1 mRNA CTD PMID:28284560 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression
multiple interactions
ISO Niclosamide results in increased expression of EIF2AK3 mRNA
ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]; Niclosamide results in increased expression of and results in increased phosphorylation of EIF2AK3 protein
CTD PMID:26917416 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Niclosamide results in increased phosphorylation of EIF2S1 protein CTD PMID:26917416 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:19771169 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression
multiple interactions
decreases phosphorylation
ISO Niclosamide analog results in decreased expression of EIF4EBP1 protein modified form; Niclosamide results in decreased expression of EIF4EBP1 protein modified form
Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]
Niclosamide results in decreased phosphorylation of EIF4EBP1 protein
CTD PMID:19771169 PMID:28284560 PMID:30258081 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Endod1 endonuclease domain containing 1 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA] CTD PMID:27542212 NCBI chr 8:11,209,123...11,238,680
Ensembl chr 8:11,211,110...11,238,892
JBrowse link
G Eno2 enolase 2 increases expression ISO Niclosamide results in increased expression of ENO2 mRNA CTD PMID:22576131 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Eno3 enolase 3 decreases expression ISO Niclosamide results in decreased expression of ENO3 mRNA CTD PMID:22576131 NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
JBrowse link
G Ep300 E1A binding protein p300 increases expression ISO Niclosamide results in increased expression of EP300 mRNA CTD PMID:22576131 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Eps8l3 EPS8 like 3 increases expression ISO Niclosamide results in increased expression of EPS8L3 mRNA CTD PMID:28284560 Ensembl chr 2:195,514,692...195,528,085 JBrowse link
G Fam83d family with sequence similarity 83, member D decreases expression ISO Niclosamide results in decreased expression of FAM83D mRNA CTD PMID:28284560 NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO
EXP
Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of TCF7 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FAS mRNA]
CTD PMID:28318631 PMID:33632240 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO Niclosamide results in decreased expression of FGF1 mRNA; Niclosamide results in decreased expression of FGF1 protein CTD PMID:25174399 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions
decreases expression
ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of FKBP5 mRNA
Niclosamide results in decreased expression of FKBP5 mRNA
CTD PMID:28500234 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]
CTD PMID:28318631 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]
CTD PMID:26792726 PMID:28824321 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Niclosamide results in increased expression of FOSB mRNA CTD PMID:28284560 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Niclosamide results in increased expression of FOSL1 mRNA CTD PMID:22576131 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Foxm1 forkhead box M1 multiple interactions
decreases expression
ISO Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of FOXM1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of FOXM1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of FOXM1 protein] CTD PMID:27492973 NCBI chr 4:161,639,561...161,652,012
Ensembl chr 4:161,638,816...161,650,684
JBrowse link
G Fscn1 fascin actin-bundling protein 1 multiple interactions ISO Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of FSCN1 mRNA] CTD PMID:29733962 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211
JBrowse link
G Fzd1 frizzled class receptor 1 affects localization ISO Niclosamide affects the localization of FZD1 protein CTD PMID:19772353 NCBI chr 4:29,310,303...29,314,701 JBrowse link
G Fzd2 frizzled class receptor 2 decreases expression ISO Niclosamide results in decreased expression of FZD2 mRNA CTD PMID:22576131 NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
JBrowse link
G Fzd5 frizzled class receptor 5 increases expression ISO Niclosamide results in increased expression of FZD5 mRNA CTD PMID:22576131 NCBI chr 9:66,117,370...66,119,127
Ensembl chr 9:66,113,112...66,121,457
JBrowse link
G Fzd9 frizzled class receptor 9 decreases expression ISO Niclosamide results in decreased expression of FZD9 mRNA CTD PMID:22576131 NCBI chr12:21,427,084...21,429,398
Ensembl chr12:21,427,084...21,429,398
JBrowse link
G Gcg glucagon multiple interactions EXP Niclosamide inhibits the reaction [GCG protein results in increased abundance of Cyclic AMP]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein] CTD PMID:26964897 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression ISO Niclosamide results in increased expression of GOT2 mRNA CTD PMID:22576131 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression
decreases phosphorylation
ISO Niclosamide results in decreased expression of GSK3B mRNA
Niclosamide results in decreased phosphorylation of GSK3B protein
CTD PMID:22576131 PMID:30143678 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gtse1 G-2 and S-phase expressed 1 decreases expression ISO Niclosamide results in decreased expression of GTSE1 mRNA CTD PMID:28284560 NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase decreases expression ISO Niclosamide results in decreased expression of HADH mRNA CTD PMID:22576131 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression
increases expression
ISO Niclosamide results in decreased expression of HAMP mRNA
Niclosamide results in increased expression of HAMP mRNA
CTD PMID:25633564 PMID:28284560 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hbp1 HMG-box transcription factor 1 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA] CTD PMID:27542212 NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787
JBrowse link
G Hes1 hes family bHLH transcription factor 1 decreases expression
multiple interactions
ISO
EXP
Niclosamide results in decreased expression of HES1 protein
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HES1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HES1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]]
CTD PMID:19160421 PMID:28318631 PMID:32961231 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 multiple interactions ISO
EXP
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY1 mRNA]
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]
CTD PMID:27542212 PMID:28318631 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 multiple interactions
increases expression
EXP
ISO
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY2 mRNA]
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY2 mRNA]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA]
CTD PMID:19160421 PMID:28318631 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions
ISO Niclosamide results in decreased expression of HIF1A mRNA; Niclosamide results in decreased expression of HIF1A protein
Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]
CTD PMID:30779072 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 multiple interactions ISO
EXP
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 protein]
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]
CTD PMID:28318631 NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223
JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO Niclosamide results in decreased expression of HMMR mRNA CTD PMID:28284560 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
JBrowse link
G Hoxa1 homeobox A1 increases expression ISO Niclosamide results in increased expression of HOXA1 CTD PMID:26820057 NCBI chr 4:81,255,814...81,258,504
Ensembl chr 4:81,255,883...81,258,504
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ICAM1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of ICAM1 mRNA]
CTD PMID:28318631 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects response to substance ISO IGF1R protein affects the susceptibility to Niclosamide CTD PMID:27497986 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta affects localization ISO Niclosamide affects the localization of IKBKB protein CTD PMID:26116531 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma affects localization ISO Niclosamide affects the localization of IKBKG protein CTD PMID:26116531 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA] CTD PMID:26297436 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA] CTD PMID:33524445 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il21 interleukin 21 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL21 protein] CTD PMID:33632240 NCBI chr 2:120,119,598...120,126,941
Ensembl chr 2:120,119,444...120,126,996
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL6 protein]
Niclosamide inhibits the reaction [IL6 protein results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of APPA mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of MYC protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of SOCS1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of TGFB1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]
CTD PMID:24561310 PMID:25970160 PMID:26297436 PMID:28318631 PMID:33632240 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGAV mRNA] CTD PMID:26792726 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]
CTD PMID:26792726 PMID:28824321 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects localization
multiple interactions
increases phosphorylation
increases expression
EXP
ISO
Niclosamide affects the localization of JUN protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]]; Acetylcysteine inhibits the reaction [Niclosamide results in increased phosphorylation of JUN protein]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]
Niclosamide results in increased expression of JUN mRNA
CTD PMID:24750999 PMID:27338550 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kif11 kinesin family member 11 decreases expression ISO Niclosamide results in decreased expression of KIF11 mRNA CTD PMID:28284560 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO Niclosamide results in decreased expression of KIF20A mRNA CTD PMID:28284560 NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
JBrowse link
G Kifc1 kinesin family member C1 decreases expression ISO Niclosamide results in decreased expression of KIFC1 mRNA CTD PMID:28284560 NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105
JBrowse link
G Lcat lecithin cholesterol acyltransferase increases expression ISO Niclosamide results in increased expression of LCAT mRNA CTD PMID:28284560 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
JBrowse link
G Ldha lactate dehydrogenase A increases expression ISO Niclosamide results in increased expression of LDHA mRNA CTD PMID:22576131 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions EXP Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]] CTD PMID:32961231 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581
JBrowse link
G Lrp6 LDL receptor related protein 6 decreases expression
multiple interactions
ISO
EXP
Niclosamide analog results in decreased expression of LRP6 protein; Niclosamide results in decreased expression of LRP6 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]]
Niclosamide results in decreased expression of and results in decreased phosphorylation of LRP6 protein
CTD PMID:24552774 PMID:24736023 PMID:28284560 PMID:32961231 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO Niclosamide results in decreased expression of MAD2L1 mRNA CTD PMID:28284560 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO Niclosamide results in increased expression of MAP1LC3B protein modified form CTD PMID:30258081 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO Niclosamide results in decreased phosphorylation of MAPK1 protein
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Niclosamide results in decreased phosphorylation of MAPK3 protein
CTD PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein] CTD PMID:28824321 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein] CTD PMID:28824321 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Niclosamide results in decreased expression of MCL1 protein CTD PMID:20215516 PMID:26116531 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO Niclosamide results in decreased expression of MCM2 mRNA; Niclosamide results in decreased expression of MCM2 protein CTD PMID:28284560 PMID:29031202 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO Niclosamide results in decreased expression of MCM7 protein CTD PMID:29031202 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression EXP Niclosamide results in decreased expression of MET mRNA CTD PMID:27338550 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Niclosamide results in decreased expression of MKI67 mRNA CTD PMID:28284560 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mme membrane metallo-endopeptidase decreases expression ISO Niclosamide results in decreased expression of MME mRNA; Niclosamide results in decreased expression of MME protein CTD PMID:29480568 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Niclosamide results in decreased expression of MMP2 mRNA; Niclosamide results in decreased expression of MMP2 protein CTD PMID:29251334 PMID:30143678 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions
decreases expression
EXP
ISO
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of MMP7 mRNA]
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of MMP7 mRNA]
Niclosamide results in decreased expression of MMP7 mRNA
CTD PMID:27338550 PMID:28318631 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO Niclosamide results in decreased expression of MMP9 mRNA; Niclosamide results in decreased expression of MMP9 protein
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]
CTD PMID:28824321 PMID:29480568 PMID:30143678 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mt2A metallothionein 2A increases expression ISO Niclosamide results in increased expression of MT2A mRNA CTD PMID:28284560 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions
increases expression
ISO Niclosamide analog results in decreased phosphorylation of MTOR protein; Niclosamide results in decreased phosphorylation of MTOR protein
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of MTOR protein]; Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]
Niclosamide results in increased expression of MTOR mRNA
CTD PMID:19771169 PMID:26643609 PMID:26703449 PMID:28284560 PMID:29843133 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
EXP
ISO
Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]
Niclosamide results in decreased expression of MYC mRNA; Niclosamide results in decreased expression of MYC protein
[Niclosamide binds to Polyethyleneimine] which results in increased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC protein; enzalutamide promotes the reaction [Niclosamide results in decreased expression of MYC protein]; Niclosamide inhibits the reaction [bicalutamide results in increased expression of MYC protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of MYC protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of MYC mRNA]
CTD PMID:19160421 PMID:20215516 PMID:22576131 PMID:25970160 PMID:25988281 More... NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 decreases expression ISO Niclosamide results in decreased expression of NDUFA10 mRNA CTD PMID:22576131 NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560
JBrowse link
G Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 increases expression ISO Niclosamide results in increased expression of NDUFA4L2 mRNA CTD PMID:22576131 NCBI chr 7:63,351,021...63,359,010
Ensembl chr 7:63,356,883...63,359,010
JBrowse link
G Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 decreases expression ISO Niclosamide results in decreased expression of NDUFA7 mRNA CTD PMID:22576131 NCBI chr 7:14,609,283...14,622,064
Ensembl chr 7:14,609,146...14,631,976
JBrowse link
G Ndufa8 NADH:ubiquinone oxidoreductase subunit A8 decreases expression ISO Niclosamide results in decreased expression of NDUFA8 mRNA CTD PMID:22576131 NCBI chr 3:19,386,063...19,402,093
Ensembl chr 3:19,386,065...19,402,071
JBrowse link
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 decreases expression ISO Niclosamide results in decreased expression of NDUFB10 mRNA CTD PMID:22576131 NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442
JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 decreases expression ISO Niclosamide results in decreased expression of NDUFB6 mRNA CTD PMID:22576131 NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181
JBrowse link
G Ndufc1 NADH:ubiquinone oxidoreductase subunit C1 increases expression ISO Niclosamide results in increased expression of NDUFC1 mRNA CTD PMID:22576131 NCBI chr 2:135,447,067...135,450,950
Ensembl chr 2:135,447,119...135,450,874
JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 decreases expression ISO Niclosamide results in decreased expression of NDUFS2 mRNA CTD PMID:22576131 NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420
JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 decreases expression ISO Niclosamide results in decreased expression of NDUFS3 mRNA CTD PMID:22576131 NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824
JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 decreases expression ISO Niclosamide results in decreased expression of NDUFS7 mRNA CTD PMID:22576131 NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195
JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 decreases expression ISO Niclosamide results in decreased expression of NDUFS8 mRNA CTD PMID:22576131 NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511
JBrowse link
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 increases expression ISO Niclosamide results in increased expression of NDUFV3 mRNA CTD PMID:22576131 NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]
CTD PMID:26792726 PMID:28824321 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO Niclosamide affects the localization of NFKB1 protein CTD PMID:26116531 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions
ISO Niclosamide results in decreased phosphorylation of NFKBIA protein
Niclosamide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Niclosamide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Niclosamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]
CTD PMID:20215516 PMID:26116531 PMID:27492973 PMID:28824321 PMID:33524445 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nkd1 NKD inhibitor of WNT signaling pathway 1 multiple interactions
increases expression
ISO Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of NKD1 mRNA]
Niclosamide results in increased expression of NKD1 mRNA
CTD PMID:22576131 PMID:24534281 NCBI chr19:18,476,344...18,549,380
Ensembl chr19:18,476,344...18,549,380
JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions
decreases expression
ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of NKX3-1 mRNA
Niclosamide results in decreased expression of NKX3-1 mRNA
CTD PMID:28500234 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein] CTD PMID:33524445 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Notch1 notch receptor 1 decreases activity
multiple interactions
ISO
EXP
Niclosamide results in decreased activity of NOTCH1 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]]
CTD PMID:19160421 PMID:32961231 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Niclosamide binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Ocstamp osteoclast stimulatory transmembrane protein multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA] CTD PMID:28824321 NCBI chr 3:154,131,113...154,141,611
Ensembl chr 3:154,132,328...154,136,991
JBrowse link
G Orc1 origin recognition complex, subunit 1 decreases expression ISO Niclosamide results in decreased expression of ORC1 mRNA CTD PMID:28284560 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375
JBrowse link
G Oscar osteoclast associated Ig-like receptor multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]
CTD PMID:26792726 PMID:28824321 NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression
increases expression
increases cleavage
ISO [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased cleavage of PARP1 protein
Niclosamide results in decreased expression of PARP1 protein
Niclosamide results in increased expression of PARP1 protein modified form
Niclosamide results in increased cleavage of PARP1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Niclosamide results in increased cleavage of PARP1 protein]; bicalutamide promotes the reaction [Niclosamide results in increased expression of PARP1 protein modified form]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]
CTD PMID:24750999 PMID:25174399 PMID:26917416 PMID:28500234 PMID:30258081 More... NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pc pyruvate carboxylase increases expression ISO Niclosamide results in increased expression of PC mRNA CTD PMID:22576131 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pfkm phosphofructokinase, muscle decreases expression ISO Niclosamide results in decreased expression of PFKM mRNA CTD PMID:22576131 NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 increases expression ISO Niclosamide results in increased expression of PHLDA1 mRNA CTD PMID:28284560 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases expression
multiple interactions
ISO Niclosamide results in increased expression of PIK3CA mRNA
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CXCL8 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA]
CTD PMID:27542212 PMID:29843133 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pkm pyruvate kinase M1/2 increases expression ISO Niclosamide results in increased expression of PKM mRNA CTD PMID:22576131 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases phosphorylation ISO Niclosamide results in decreased phosphorylation of POU5F1 protein CTD PMID:23333246 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO Niclosamide results in increased expression of PPARD mRNA CTD PMID:22576131 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression ISO Niclosamide results in decreased expression of PPP2CB mRNA CTD PMID:22576131 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression ISO Niclosamide results in increased expression of PPP2R1A mRNA CTD PMID:22576131 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA] CTD PMID:27542212 NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485
JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta decreases expression ISO Niclosamide results in decreased expression of PPP2R2B mRNA CTD PMID:22576131 NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025
JBrowse link
G Ppp2r2c protein phosphatase 2, regulatory subunit B, gamma decreases expression ISO Niclosamide results in decreased expression of PPP2R2C mRNA CTD PMID:22576131 NCBI chr14:73,846,547...73,931,178
Ensembl chr14:73,846,547...73,931,864
JBrowse link
G Prdm1 PR/SET domain 1 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA] CTD PMID:33632240 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
JBrowse link
G Prkcq protein kinase C, theta increases expression ISO Niclosamide results in increased expression of PRKCQ mRNA CTD PMID:22576131 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704
JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Niclosamide results in increased expression of PTEN mRNA CTD PMID:29843133 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Rad54l RAD54 like increases expression ISO Niclosamide results in increased expression of RAD54L mRNA CTD PMID:28284560 NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation
decreases expression
ISO Niclosamide analog results in decreased phosphorylation of RAF1 protein
Niclosamide analog results in decreased expression of RAF1 protein; Niclosamide results in decreased expression of RAF1 protein
CTD PMID:28284560 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO
EXP
Niclosamide affects the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of and results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of RELA protein modified form]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of RELA protein modified form]
Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of RELA protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of RELA protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of RELA protein]; Niclosamide results in decreased phosphorylation of and affects the localization of RELA protein
CTD PMID:20215516 PMID:26116531 PMID:26643609 PMID:27492973 PMID:28318631 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rhof ras homolog family member F, filopodia associated multiple interactions ISO Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of RHOF mRNA] CTD PMID:29733962 NCBI chr12:33,422,375...33,446,689
Ensembl chr12:33,431,280...33,446,703
JBrowse link
G Ripor3 RIPOR family member 3 increases expression ISO Niclosamide results in increased expression of FAM65C mRNA CTD PMID:28284560 NCBI chr 3:156,687,253...156,760,524
Ensembl chr 3:156,687,517...156,715,061
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO Niclosamide results in decreased expression of ROCK1 mRNA; Niclosamide results in decreased expression of ROCK1 protein CTD PMID:29251334 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Rps6 ribosomal protein S6 affects phosphorylation ISO Niclosamide affects the phosphorylation of RPS6 protein CTD PMID:27542212 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO Niclosamide results in decreased phosphorylation of RPS6KB1 protein CTD PMID:27542212 PMID:30258081 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO Niclosamide results in decreased expression of RRM2 mRNA CTD PMID:28284560 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression ISO Niclosamide results in decreased expression of RUNX2 mRNA CTD PMID:28824321 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression
multiple interactions
ISO Niclosamide results in decreased expression of S100A4 mRNA; Niclosamide results in decreased expression of S100A4 protein
Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of S100A4 protein]
CTD PMID:21685359 PMID:29733962 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Niclosamide inhibits the reaction [Doxorubicin results in increased expression of SERPINE1 mRNA] CTD PMID:28318631 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Serpine2 serpin family E member 2 multiple interactions EXP Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE2 mRNA] CTD PMID:28318631 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO Niclosamide results in decreased expression of SLC2A1 mRNA CTD PMID:22576131 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Niclosamide results in decreased expression of SLC2A3 mRNA CTD PMID:22576131 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO
EXP
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
Niclosamide inhibits the reaction [Doxorubicin results in increased phosphorylation of SMAD3 protein]
CTD PMID:28318631 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions
decreases expression
ISO
EXP
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of SNAI1 mRNA]
Niclosamide results in decreased expression of SNAI1 mRNA; Niclosamide results in decreased expression of SNAI1 protein
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of SNAI1 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]
CTD PMID:26643609 PMID:28318631 PMID:30143678 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions
decreases expression
ISO WNT7A protein affects the reaction [Niclosamide results in increased expression of SNAI2 protein]
Niclosamide results in decreased expression of SNAI2 protein
CTD PMID:25174399 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of SRC protein] CTD PMID:26643609 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation
multiple interactions
decreases expression
ISO Niclosamide analog results in decreased phosphorylation of STAT3 protein; Niclosamide results in decreased phosphorylation of STAT3 protein
Niclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein]
[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; enzalutamide promotes the reaction [Niclosamide results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Niclosamide inhibits the reaction [STAT3 protein results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of STAT3 protein]; Niclosamide results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of STAT3 protein; Niclosamide results in decreased expression of and results in decreased phosphorylation of STAT3 protein
Niclosamide analog results in decreased expression of STAT3 protein; Niclosamide results in decreased expression of STAT3 protein
CTD PMID:23333246 PMID:23894143 PMID:24552774 PMID:25970160 PMID:26116531 More... NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tacc3 transforming, acidic coiled-coil containing protein 3 decreases expression ISO Niclosamide results in decreased expression of TACC3 mRNA CTD PMID:28284560 NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219
JBrowse link
G Tcf7 transcription factor 7 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of TCF7 protein] CTD PMID:33632240 NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535
JBrowse link
G Tcim transcriptional and immune response regulator increases expression ISO Niclosamide results in increased expression of TCIM mRNA CTD PMID:28284560 NCBI chr16:67,595,762...67,597,055
Ensembl chr16:67,593,410...67,597,581
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL20 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FAS mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HES1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of ICAM1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of MMP7 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of RELA protein modified form]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
CTD PMID:28318631 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO Niclosamide results in increased expression of TIMP2 mRNA CTD PMID:30143678 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO Niclosamide results in decreased expression of TK1 mRNA CTD PMID:28284560 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF mRNA]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of FOXM1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of MYC mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
Niclosamide results in decreased activity of TNF protein
CTD PMID:20215516 PMID:24561310 PMID:27492973 PMID:28318631 PMID:33524445 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGAV mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of STAT3 protein]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]
CTD PMID:26792726 PMID:28824321 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
decreases response to substance
increases response to substance
ISO [Niclosamide binds to Polyethyleneimine] which results in increased expression of TP53 mRNA; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of BBC3 mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP3 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]
[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of adrenic acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Arachidonic Acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Docosahexaenoic Acids; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Eicosapentaenoic Acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Lysophosphatidylcholines; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of lysophosphatidylethanolamine; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased cleavage of PARP1 protein; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased expression of CASP3 protein modified form
Niclosamide results in increased expression of TP53 mRNA; Niclosamide results in increased expression of TP53 protein
TP53 protein results in decreased susceptibility to Niclosamide
TP53 gene mutant form results in increased susceptibility to Niclosamide; TP53 protein mutant form results in increased susceptibility to Niclosamide
Niclosamide results in increased expression of TRP53 protein
CTD PMID:22576131 PMID:25988281 PMID:29031202 PMID:30258081 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression ISO Niclosamide results in increased expression of TPI1 mRNA CTD PMID:22576131 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
JBrowse link
G Tpx2 TPX2, microtubule nucleation factor decreases expression ISO Niclosamide results in decreased expression of TPX2 mRNA CTD PMID:28284560 NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein] CTD PMID:28824321 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 decreases expression ISO Niclosamide results in decreased expression of TRIP13 mRNA CTD PMID:28284560 NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074
JBrowse link
G Twist1 twist family bHLH transcription factor 1 decreases expression ISO Niclosamide results in decreased expression of TWIST1 protein CTD PMID:29480568 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions
decreases expression
ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of UBE2C mRNA
Niclosamide results in decreased expression of UBE2C mRNA
CTD PMID:28500234 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO Niclosamide results in decreased expression of UHRF1 mRNA CTD PMID:28284560 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
JBrowse link
G Utp3 UTP3, small subunit processome component decreases expression ISO Niclosamide results in decreased expression of UTP3 mRNA CTD PMID:27226553 NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Niclosamide results in decreased expression of VEGFA mRNA; Niclosamide results in decreased expression of VEGFA protein CTD PMID:29251334 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin multiple interactions
decreases expression
ISO HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of VIM protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]
Niclosamide results in decreased expression of VIM mRNA; Niclosamide results in decreased expression of VIM protein
CTD PMID:26643609 PMID:28318631 PMID:30143678 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Vpreb1 V-set pre-B cell surrogate light chain 1 decreases expression ISO Niclosamide results in decreased expression of VPREB1 mRNA CTD PMID:27226553 NCBI chr11:84,126,969...84,127,846
Ensembl chr11:84,126,969...84,127,846
JBrowse link
G Wnt2b Wnt family member 2B decreases expression ISO Niclosamide results in decreased expression of WNT2B mRNA CTD PMID:22576131 NCBI chr 2:192,454,226...192,468,599
Ensembl chr 2:192,453,824...192,470,308
JBrowse link
G Wnt3 Wnt family member 3 decreases expression ISO Niclosamide results in decreased expression of WNT3 mRNA CTD PMID:22576131 NCBI chr10:88,680,248...88,724,170
Ensembl chr10:88,680,248...88,724,099
JBrowse link
G Wnt3a Wnt family member 3A multiple interactions
decreases expression
ISO
EXP
Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein]
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of WNT3A mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of WNT3A mRNA]]
Niclosamide results in decreased expression of WNT3A mRNA
CTD PMID:19772353 PMID:22576131 PMID:27492973 PMID:32961231 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324
JBrowse link
G Wnt7a Wnt family member 7A increases response to substance
multiple interactions
decreases activity
ISO WNT7A protein results in increased susceptibility to Niclosamide
WNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of SNAI2 protein]
Niclosamide results in decreased activity of WNT7A protein
CTD PMID:25174399 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO Niclosamide results in decreased expression of XIAP protein CTD PMID:20215516 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO Niclosamide results in increased expression of ZFP36 mRNA CTD PMID:28284560 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
JBrowse link
G Zic2 Zic family member 2 increases expression ISO Niclosamide results in increased expression of ZIC2 mRNA CTD PMID:28284560 NCBI chr15:99,576,697...99,581,522
Ensembl chr15:99,576,697...99,581,522
JBrowse link
S3I-201 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak2 Janus kinase 2 multiple interactions ISO S3I-201 inhibits the reaction [Rapamycin increases phosphorylation of JAK2 protein in lung epithelium] RGD PMID:30755242 RGD:149735343 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
stattic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO stattic inhibits the reaction [Arsenicals results in increased phosphorylation of AKT1 protein] CTD PMID:23255093 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO stattic results in decreased expression of BCL2 protein CTD PMID:24627483 PMID:25611565 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO stattic inhibits the reaction [glycine-extended gastrin 17 results in increased expression of BCL2L1 mRNA] CTD PMID:19153190 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO stattic inhibits the reaction [glycine-extended gastrin 17 results in increased expression of BIRC5 mRNA] CTD PMID:19153190 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased expression of CCN2 mRNA]
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCN2 mRNA]
CTD PMID:25740948 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP
ISO
stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 protein]
stattic affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]
CTD PMID:30670587 PMID:33396024 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]] CTD PMID:33396024 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 mRNA]] CTD PMID:33396024 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cish cytokine inducible SH2-containing protein multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased expression of CISH mRNA] CTD PMID:26297436 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased expression of COL1A1 mRNA]
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A1 mRNA]
CTD PMID:25740948 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 protein]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 protein] CTD PMID:30670587 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egf epidermal growth factor multiple interactions ISO stattic inhibits the reaction [EGF protein results in increased expression of PSMB5 protein]; stattic inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein] CTD PMID:24627483 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions ISO stattic inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein] CTD PMID:23255093 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO stattic inhibits the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GPT protein] CTD PMID:28887131 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A protein] CTD PMID:29341321 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO stattic inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein] CTD PMID:29329563 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il12a interleukin 12A multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA] CTD PMID:26297436 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO stattic inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of IL1B mRNA] CTD PMID:22454431 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [stattic co-treated with IL6 protein] results in increased expression of SOCS3 protein; stattic affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein]; stattic inhibits the reaction [IL6 protein results in increased activity of TGFB1 protein]; stattic inhibits the reaction [IL6 protein results in increased expression of APPA mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of CCN2 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of CISH mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of COL1A1 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A protein]; stattic inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
stattic inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]; stattic inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of IL6 mRNA]
CTD PMID:22454431 PMID:25740948 PMID:26297436 PMID:28739487 PMID:29341321 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO stattic inhibits the reaction [deoxynivalenol results in increased expression of JAK2 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of JAK2 mRNA] CTD PMID:22454431 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein] CTD PMID:24434654 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mir21 microRNA 21 affects expression
multiple interactions
ISO stattic affects the expression of MIR21 mRNA
stattic affects the reaction [arsenic trichloride affects the expression of MIR21 mRNA]
CTD PMID:24434654 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO stattic results in decreased expression of MMP10 mRNA CTD PMID:22285823 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:25740948 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO stattic affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; stattic affects the reaction [CXCL8 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]] CTD PMID:33396024 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Psmb1 proteasome 20S subunit beta 1 decreases expression ISO stattic results in decreased expression of PSMB1 mRNA; stattic results in decreased expression of PSMB1 protein CTD PMID:24627483 NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560
JBrowse link
G Psmb2 proteasome 20S subunit beta 2 decreases expression ISO stattic results in decreased expression of PSMB2 mRNA; stattic results in decreased expression of PSMB2 protein CTD PMID:24627483 NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137
JBrowse link
G Psmb3 proteasome 20S subunit beta 3 decreases expression ISO stattic results in decreased expression of PSMB3 mRNA; stattic results in decreased expression of PSMB3 protein CTD PMID:24627483 NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521
JBrowse link
G Psmb4 proteasome 20S subunit beta 4 decreases expression ISO stattic results in decreased expression of PSMB4 mRNA; stattic results in decreased expression of PSMB4 protein CTD PMID:24627483 NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746
JBrowse link
G Psmb5 proteasome 20S subunit beta 5 decreases expression
multiple interactions
ISO stattic results in decreased expression of PSMB5 mRNA; stattic results in decreased expression of PSMB5 protein
stattic inhibits the reaction [EGF protein results in increased expression of PSMB5 protein]
CTD PMID:24627483 NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440
JBrowse link
G Psmb6 proteasome 20S subunit beta 6 decreases expression ISO stattic results in decreased expression of PSMB6 mRNA; stattic results in decreased expression of PSMB6 protein CTD PMID:24627483 NCBI chr10:55,239,274...55,241,581
Ensembl chr10:55,239,241...55,241,586
JBrowse link
G Psmb7 proteasome 20S subunit beta 7 decreases expression ISO stattic results in decreased expression of PSMB7 mRNA; stattic results in decreased expression of PSMB7 protein CTD PMID:24627483 NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937
JBrowse link
G Riox2 ribosomal oxygenase 2 multiple interactions ISO stattic inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of RIOX2 protein] CTD PMID:24434654 NCBI chr11:40,861,365...40,884,782
Ensembl chr11:40,860,774...40,884,574
JBrowse link
G Skp2 S-phase kinase associated protein 2 multiple interactions EXP stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 protein] CTD PMID:30670587 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 mRNA]] CTD PMID:33396024 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 mRNA]] CTD PMID:33396024 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO [stattic co-treated with IL6 protein] results in increased expression of SOCS3 protein CTD PMID:25740948 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO stattic inhibits the reaction [deoxynivalenol results in increased expression of STAT1 mRNA]; stattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT1 protein]; stattic inhibits the reaction [T-2 Toxin results in increased expression of STAT1 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT1 protein] CTD PMID:22454431 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO
EXP
stattic affects the reaction [Arsenicals affects the phosphorylation of STAT3 protein]; stattic affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein]; stattic inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
Stattic inhibits the reaction [Il-6 increases phosphorylation of STAT3 protein in the stomach)
stattic inhibits the reaction [zoniporide results in increased phosphorylation of STAT3 protein]
stattic inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [deoxynivalenol results in increased expression of STAT3 mRNA]; stattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [T-2 Toxin results in increased expression of STAT3 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein]
stattic results in decreased phosphorylation of STAT3 protein
CTD
RGD
PMID:20942815 PMID:22454431 PMID:23255093 PMID:24627483 PMID:25740948 More... RGD:127284846 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased activity of TGFB1 protein]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1 mRNA]
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TGFB1 mRNA]
CTD PMID:25740948 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO stattic inhibits the reaction [deoxynivalenol results in increased expression of TNF mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of TNF mRNA] CTD PMID:22454431 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions ISO stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 mRNA]] CTD PMID:33396024 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Vim vimentin multiple interactions ISO stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM mRNA]] CTD PMID:33396024 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
tyrphostin B42 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO tyrphostin B42 alone or co-treated with Nimesulide decreases expression of BIRC5 protein in esophagus squamous epithelium RGD PMID:25724470 RGD:127285656 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 multiple interactions ISO tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases cleavage of CASP3 protein in stomach] RGD PMID:32106377 RGD:127284886 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid decreases cleavage of CASP9 protein in stomach] RGD PMID:32106377 RGD:127284886 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Jak2 Janus kinase 2 decreases expression
multiple interactions
EXP
ISO
Turphostin B42 decreased expression of Jak2 mRNA in myofibroblasts
tyrphostin B42 inhibits the reaction [cisplatin increases expression of Jak2 mRNA in kidney]
tyrphostin B42 inhibits the reaction [selumetinib increases phosphorylation of JAK2 protein in colonic epithelium]
tyrphostin B42 decreases expression and phosphorylation of JAK2 protein in colonic epithelium
tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases phosphorylation of JAK2 protein in stomach]
RGD PMID:26385087 PMID:31250048 PMID:30706361 PMID:22050790 PMID:32106377 RGD:18337263, RGD:149735351, RGD:127285668, RGD:127285665, RGD:127284886 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO Tyrphostin B42 alone or co-treated with Nimesulide decreases expression of MT-CO2 protein in esophagus squamous epithelium RGD PMID:25724470 RGD:127285656 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases phosphorylation of STAT3 protein in stomach] RGD PMID:32106377 RGD:127284886 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          STAT3 inhibitor 291
            S3I-201 1
            STAT3 inhibitor peptide 0
            niclosamide 268
            stattic 43
            trichothecin 0
            tyrphostin B42 6
paths to the root