STAT3 inhibitor - Ontology Report

Niclosamide results in decreased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

Acp5

acid phosphatase 5, tartrate resistant

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

Acsl1

acyl-CoA synthetase long-chain family member 1

decreases expression

Niclosamide results in decreased expression of ACSL1 mRNA

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

Acta2

actin alpha 2, smooth muscle

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ACTA2 protein]
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of ACTA2 protein]

PMID:26643609 PMID:28318631

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

Adh4

alcohol dehydrogenase 4 (class II), pi polypeptide

decreases expression

Niclosamide results in decreased expression of ADH4 mRNA

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591

Afp

alpha-fetoprotein

multiple interactions

Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]]

PMID:32961231

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

Aifm1

apoptosis inducing factor, mitochondria associated 1

increases cleavage

Niclosamide results in increased cleavage of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

Akt1

AKT serine/threonine kinase 1

increases expression
multiple interactions

Niclosamide results in increased expression of AKT1 mRNA
Niclosamide inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein]

PMID:20215516 PMID:26792726 PMID:29843133

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

Aldh1a1

aldehyde dehydrogenase 1 family, member A1

decreases expression

Niclosamide results in decreased expression of ALDH1A1 protein

PMID:24736023

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

Aldob

aldolase, fructose-bisphosphate B

increases expression

Niclosamide results in increased expression of ALDOB mRNA

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

Aldoc

aldolase, fructose-bisphosphate C

decreases expression

Niclosamide results in decreased expression of ALDOC mRNA

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

Alox12b

arachidonate 12-lipoxygenase, 12R type

increases expression
multiple interactions
decreases response to substance

Niclosamide results in increased expression of ALOX12B mRNA
TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]
ALOX12B protein results in decreased susceptibility to Niclosamide

NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938

Alox5

arachidonate 5-lipoxygenase

multiple interactions
decreases response to substance
increases expression

TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]
ALOX5 protein results in decreased susceptibility to Niclosamide

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

Alpl

alkaline phosphatase, biomineralization associated

decreases expression

Niclosamide results in decreased expression of ALPL mRNA

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

Apof

apolipoprotein F

decreases expression

Niclosamide results in decreased expression of APOF mRNA

NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946

androgen receptor

multiple interactions
decreases expression

[enzalutamide co-treated with Niclosamide] results in decreased expression of AR protein; [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]] which results in decreased expression of KLK3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein]; Niclosamide inhibits the reaction [AR protein alternative form binds to KLK3 promoter]; Niclosamide inhibits the reaction [AR protein alternative form results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 protein]; Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]; Niclosamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form
Niclosamide results in decreased expression of AR protein; Niclosamide results in decreased expression of AR protein alternative form

PMID:24740322 PMID:25970160 PMID:28500234

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

Araf

A-Raf proto-oncogene, serine/threonine kinase

decreases expression

Niclosamide analog results in decreased expression of ARAF protein; Niclosamide results in decreased expression of ARAF protein

NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073

Asf1b

anti-silencing function 1B histone chaperone

decreases expression

Niclosamide results in decreased expression of ASF1B mRNA

NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549

Atf3

activating transcription factor 3

increases expression
multiple interactions

Niclosamide results in increased expression of ATF3 mRNA; Niclosamide results in increased expression of ATF3 protein
ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]; ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

Atf4

activating transcription factor 4

increases expression

Niclosamide results in increased expression of ATF4 mRNA; Niclosamide results in increased expression of ATF4 protein

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

Atp5f1a

ATP synthase F1 subunit alpha

increases expression

Niclosamide results in increased expression of ATP5F1A mRNA

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

Atp5f1d

ATP synthase F1 subunit delta

increases expression

Niclosamide results in increased expression of ATP5F1D mRNA

NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929

Atp5mc3

ATP synthase membrane subunit c locus 3

decreases expression

Niclosamide results in decreased expression of ATP5MC3 mRNA

NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279

Atp5mf

ATP synthase membrane subunit f

decreases expression

Niclosamide results in decreased expression of ATP5MF mRNA

NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236

Atp5mg

ATP synthase membrane subunit g

decreases expression

Niclosamide results in decreased expression of ATP5MG mRNA

NCBI chr 8:45,226,750...45,233,582
Ensembl chr 8:45,225,686...45,233,559

Atp5pb

ATP synthase peripheral stalk-membrane subunit b

decreases expression

Niclosamide results in decreased expression of ATP5PB mRNA

NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418

Atp6ap1

ATPase H+ transporting accessory protein 1

decreases expression

Niclosamide results in decreased expression of ATP6AP1 mRNA

NCBI chr X:152,079,954...152,087,034
Ensembl chr X:152,079,865...152,087,034

Atp6v0d2

ATPase H+ transporting V0 subunit D2

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]

PMID:26792726

NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354

Aurkb

aurora kinase B

decreases expression

Niclosamide results in decreased expression of AURKB mRNA

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

Axin2

axin 2

multiple interactions
decreases expression

Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA]
Niclosamide results in decreased expression of AXIN2 mRNA; Niclosamide results in decreased expression of AXIN2 protein

PMID:22576131 PMID:24534281 PMID:24552774 PMID:24736023

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

Bad

BCL2-associated agonist of cell death

multiple interactions

[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAD mRNA

PMID:25988281

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

Bak1

BCL2-antagonist/killer 1

multiple interactions

[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAK1 mRNA

PMID:25988281

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

Bax

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions
decreases expression

Niclosamide results in increased expression of BAX protein
[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAX mRNA; [Niclosamide co-treated with bicalutamide] results in increased expression of BAX protein; bicalutamide inhibits the reaction [Niclosamide results in decreased expression of BAX protein]

PMID:25634333 PMID:25988281 PMID:26703449 PMID:28500234

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

Bbc3

Bcl-2 binding component 3

multiple interactions
increases expression

TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of BBC3 mRNA]

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

Bcl2

BCL2, apoptosis regulator

decreases expression
multiple interactions

Niclosamide analog results in decreased expression of BCL2 protein; Niclosamide results in decreased expression of BCL2 protein
[Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2 mRNA; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2 protein]

PMID:20215516 PMID:23894143 PMID:25634333 PMID:25988281 PMID:26116531 More...

NCBI chr13:22,689,783...22,853,920

Bcl2l1

Bcl2-like 1

multiple interactions
decreases expression

[Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2L1 mRNA; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2L1 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2L1 protein]
Niclosamide analog results in decreased expression of BCL2L1 protein; Niclosamide results in decreased expression of BCL2L1 protein

PMID:20215516 PMID:25988281 PMID:26116531 PMID:28284560 PMID:28500234

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

Bcl2l2

Bcl2-like 2

decreases expression
multiple interactions

Niclosamide results in decreased expression of BCL2L2 protein
[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]

PMID:23894143

NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624

Bcl6

BCL6, transcription repressor

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein]

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

Bcl9

BCL9, transcription coactivator

decreases expression

Niclosamide results in decreased expression of BCL9 mRNA

PMID:27338550

NCBI chr 2:184,760,616...184,846,261
Ensembl chr 2:184,760,618...184,786,435

Birc5

baculoviral IAP repeat-containing 5

multiple interactions
affects expression
decreases expression

enzalutamide promotes the reaction [Niclosamide results in decreased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein]
Niclosamide affects the expression of BIRC5 protein
Niclosamide analog results in decreased expression of BIRC5 protein; Niclosamide results in decreased expression of BIRC5 protein

PMID:24552774 PMID:24736023 PMID:25970160 PMID:28284560 PMID:28500234

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

Braf

B-Raf proto-oncogene, serine/threonine kinase

decreases expression
decreases phosphorylation

Niclosamide analog results in decreased expression of BRAF protein; Niclosamide results in decreased expression of BRAF protein
Niclosamide analog results in decreased phosphorylation of BRAF protein

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

Casp1

caspase 1

multiple interactions

[Niclosamide co-treated with Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CASP1 protein
Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein]

PMID:33524445

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

Casp3

caspase 3

increases cleavage
multiple interactions
increases expression
decreases expression

Niclosamide results in increased cleavage of CASP3 protein
Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]]
[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased expression of CASP3 protein modified form; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]
Niclosamide results in increased expression of CASP3 protein modified form
Niclosamide results in decreased expression of CASP3 protein
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; [Niclosamide binds to Polyethyleneimine] which results in increased expression of CASP3 mRNA; ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP3 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]

PMID:20215516 PMID:21871175 PMID:24750999 PMID:25174399 PMID:25634333 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Casp7

caspase 7

multiple interactions
increases expression

bicalutamide promotes the reaction [Niclosamide results in increased expression of CASP7 protein modified form]

PMID:26116531 PMID:28500234

NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729

Casp9

caspase 9

multiple interactions
increases expression
increases cleavage

TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein]
Niclosamide results in increased expression of CASP9 protein modified form

PMID:26116531 PMID:26703449 PMID:30258081

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

Ccl2

C-C motif chemokine ligand 2

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL2 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA]

PMID:24561310 PMID:28318631

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

Ccl20

C-C motif chemokine ligand 20

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL20 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL20 mRNA]

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

Ccl3

C-C motif chemokine ligand 3

multiple interactions

Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

Ccl5

C-C motif chemokine ligand 5

multiple interactions

Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL5 protein]

NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377

Ccnb1

cyclin B1

decreases expression

Niclosamide results in decreased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

Ccnd1

cyclin D1

multiple interactions
decreases expression

Niclosamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]]
Niclosamide results in decreased expression of CCND1 mRNA
Niclosamide analog results in decreased expression of CCND1 protein; Niclosamide results in decreased expression of CCND1 mRNA; Niclosamide results in decreased expression of CCND1 protein
Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of CCND1 protein]

PMID:19160421 PMID:20215516 PMID:24552774 PMID:24736023 PMID:26297436 More...

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

Ccnd2

cyclin D2

decreases expression
increases expression

Niclosamide results in decreased expression of CCND2 mRNA
Niclosamide results in increased expression of CCND2 mRNA

PMID:22576131 PMID:27226553

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

Ccnd3

cyclin D3

decreases expression

Niclosamide results in decreased expression of CCND3 mRNA

PMID:22576131 PMID:27226553

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

Ccne2

cyclin E2

multiple interactions

Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

Ccng2

cyclin G2

multiple interactions

Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

Cd40

CD40 molecule

multiple interactions

Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD40 protein]

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

Cd80

Cd80 molecule

multiple interactions

Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD80 protein]

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

Cd86

CD86 molecule

multiple interactions

Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD86 protein]

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

Cdc37

cell division cycle 37, HSP90 cochaperone

multiple interactions

CDC37 protein binds to and results in increased susceptibility to Niclosamide analog

NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809

Cdc42

cell division cycle 42

decreases expression
decreases phosphorylation

Niclosamide results in decreased expression of CDC42 mRNA
Niclosamide results in decreased phosphorylation of CDC42 protein

PMID:29251334

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

Cdc6

cell division cycle 6

decreases expression

Niclosamide results in decreased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

Cdca2

cell division cycle associated 2

decreases expression

Niclosamide results in decreased expression of CDCA2 mRNA

NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611

Cdca5

cell division cycle associated 5

decreases expression

Niclosamide results in decreased expression of CDCA5 mRNA

NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023

Cdca8

cell division cycle associated 8

decreases expression

Niclosamide results in decreased expression of CDCA8 mRNA

NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629

Cdh1

cadherin 1

multiple interactions
increases expression

Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in decreased expression of CDH1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein]
Niclosamide results in increased expression of CDH1 mRNA; Niclosamide results in increased expression of CDH1 protein

PMID:25174399 PMID:26643609 PMID:30143678

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

Cdh2

cadherin 2

multiple interactions

Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of CDH2 protein]

PMID:26643609

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

Cdk2

cyclin dependent kinase 2

decreases expression

Niclosamide results in decreased expression of CDK2 protein

PMID:29031202

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

Cdk4

cyclin-dependent kinase 4

decreases expression

Niclosamide results in decreased expression of CDK4 protein

PMID:29031202

NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403

Cdkn1a

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

Cdkn3

cyclin-dependent kinase inhibitor 3

decreases expression

Niclosamide results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

Celsr3

cadherin, EGF LAG seven-pass G-type receptor 3

increases expression

Niclosamide results in increased expression of CELSR3 mRNA

NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354

Cenpa

centromere protein A

decreases expression

Niclosamide results in decreased expression of CENPA mRNA

NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675

Cfp

complement factor properdin

increases expression

Niclosamide results in increased expression of CFP mRNA

NCBI chr X:1,162,014...1,167,576
Ensembl chr X:1,161,979...1,167,573

Chuk

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Niclosamide results in decreased phosphorylation of and affects the localization of CHUK protein

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

Col1a1

collagen type I alpha 1 chain

decreases expression

Niclosamide results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

Colec10

collectin subfamily member 10

increases expression

Niclosamide results in increased expression of COLEC10 mRNA

NCBI chr 7:85,744,895...85,806,368
Ensembl chr 7:85,744,895...85,805,675

Crebbp

CREB binding protein

increases expression

Niclosamide results in increased expression of CREBBP mRNA

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

Csf1

colony stimulating factor 1

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

Csgalnact1

chondroitin sulfate N-acetylgalactosaminyltransferase 1

multiple interactions

Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]

NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319

Csnk1e

casein kinase 1, epsilon

increases expression

Niclosamide results in increased expression of CSNK1E mRNA

NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794

Csrnp1

cysteine and serine rich nuclear protein 1

increases expression

Niclosamide results in increased expression of CSRNP1 mRNA

NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183

Ctbp1

C-terminal binding protein 1

increases expression

Niclosamide results in increased expression of CTBP1 mRNA

NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821

Ctnnb1

catenin beta 1

increases expression
decreases expression
increases ubiquitination
decreases activity
multiple interactions

Niclosamide results in increased expression of CTNNB1 mRNA
Niclosamide results in decreased expression of CTNNB1 mRNA
Niclosamide results in increased ubiquitination of CTNNB1 protein
Niclosamide results in decreased activity of CTNNB1 protein
Niclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]]
Niclosamide analog results in decreased expression of CTNNB1 protein; Niclosamide results in decreased expression of CTNNB1 protein
Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of CTNNB1 protein]; Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; Niclosamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of CTNNB1 protein]

PMID:19772353 PMID:21531761 PMID:22576131 PMID:24534281 PMID:24552774 More...

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

Ctnnbip1

catenin, beta-interacting protein 1

multiple interactions

Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]

PMID:24534281

NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939

Ctsc

cathepsin C

decreases expression

Niclosamide results in decreased expression of CTSC protein

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

Ctsd

cathepsin D

decreases expression

Niclosamide results in decreased expression of CTSD protein

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

Ctsk

cathepsin K

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]

PMID:26792726

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

Cxcr5

C-X-C motif chemokine receptor 5

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA]

NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893

Cycs

cytochrome c, somatic

increases expression

Niclosamide results in increased expression of CYCS protein

PMID:26703449

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054

Cyp1a1

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity

Niclosamide results in increased activity of CYP1A1 protein

PMID:12451431

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

Cyp1a2

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
increases expression

Niclosamide results in decreased activity of CYP1A2 protein
Niclosamide results in increased expression of CYP1A2 mRNA

PMID:11124226 PMID:28284560

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

Cyp2d4

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

Niclosamide results in decreased activity of CYP2D6 protein

PMID:11124226

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

Cyp39a1

cytochrome P450, family 39, subfamily a, polypeptide 1

increases expression

Niclosamide results in increased expression of CYP39A1 mRNA

NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775

Cyp3a2

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

Niclosamide results in decreased activity of CYP3A4 protein

PMID:11124226

NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008

Ddit3

DNA-damage inducible transcript 3

increases expression
multiple interactions

Niclosamide results in increased expression of DDIT3 mRNA; Niclosamide results in increased expression of DDIT3 protein
ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

Decr1

2,4-dienoyl-CoA reductase 1

decreases expression

Niclosamide results in decreased expression of DECR1 mRNA

NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018

Dmac2l

distal membrane arm assembly component 2 like

decreases expression

Niclosamide results in decreased expression of DMAC2L mRNA

NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933

Dscc1

DNA replication and sister chromatid cohesion 1

multiple interactions

Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]

NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212

Dvl1

dishevelled segment polarity protein 1

increases expression

Niclosamide results in increased expression of DVL1 mRNA

NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664

Dvl2

dishevelled segment polarity protein 2

decreases expression
multiple interactions

Niclosamide results in decreased expression of DVL2 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]]

PMID:19772353 PMID:21531761 PMID:30143678 PMID:32961231

NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820

Dvl3

dishevelled segment polarity protein 3

increases expression

Niclosamide results in increased expression of DVL3 mRNA

NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462

E2f1

E2F transcription factor 1

decreases expression

Niclosamide results in decreased expression of E2F1 mRNA

PMID:29843133

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

E2f8

E2F transcription factor 8

decreases expression

Niclosamide results in decreased expression of E2F8 mRNA

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

Ebf1

EBF transcription factor 1

decreases expression

Niclosamide results in decreased expression of EBF1 mRNA

PMID:27226553

NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665

Echdc1

ethylmalonyl-CoA decarboxylase 1

decreases expression

Niclosamide results in decreased expression of ECHDC1 mRNA

NCBI chr 1:28,476,354...28,507,173
Ensembl chr 1:28,476,200...28,507,319

Echs1

enoyl-CoA hydratase, short chain 1

decreases expression

Niclosamide results in decreased expression of ECHS1 mRNA

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

Egf

epidermal growth factor

decreases expression
multiple interactions

Niclosamide results in decreased expression of EGF mRNA; Niclosamide results in decreased expression of EGF protein
Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]

PMID:30779072

NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064

Egfr

epidermal growth factor receptor

decreases expression
decreases phosphorylation

Niclosamide analog results in decreased expression of EGFR protein; Niclosamide results in decreased expression of EGFR mRNA; Niclosamide results in decreased expression of EGFR protein
Niclosamide results in decreased phosphorylation of EGFR protein

PMID:28284560 PMID:28426875 PMID:30779072

NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382

Egr1

early growth response 1

increases expression

Niclosamide results in increased expression of EGR1 mRNA

NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766

Eif2ak3

eukaryotic translation initiation factor 2 alpha kinase 3

increases expression
multiple interactions

Niclosamide results in increased expression of EIF2AK3 mRNA
ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]; Niclosamide results in increased expression of and results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

Eif2s1

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

Niclosamide results in increased phosphorylation of EIF2S1 protein

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

Eif4e

eukaryotic translation initiation factor 4E

multiple interactions

Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]

PMID:19771169

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

Eif4ebp1

eukaryotic translation initiation factor 4E binding protein 1

decreases expression
multiple interactions
decreases phosphorylation

Niclosamide analog results in decreased expression of EIF4EBP1 protein modified form; Niclosamide results in decreased expression of EIF4EBP1 protein modified form
Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]
Niclosamide results in decreased phosphorylation of EIF4EBP1 protein

PMID:19771169 PMID:28284560 PMID:30258081

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

Endod1

endonuclease domain containing 1

multiple interactions

Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]

NCBI chr 8:11,209,123...11,238,680
Ensembl chr 8:11,211,110...11,238,892

Eno2

enolase 2

increases expression

Niclosamide results in increased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

Eno3

enolase 3

decreases expression

Niclosamide results in decreased expression of ENO3 mRNA

NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921

Ep300

E1A binding protein p300

increases expression

Niclosamide results in increased expression of EP300 mRNA

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

Eps8l3

EPS8 like 3

increases expression

Niclosamide results in increased expression of EPS8L3 mRNA

Ensembl chr 2:195,514,692...195,528,085

Fam83d

family with sequence similarity 83, member D

decreases expression

Niclosamide results in decreased expression of FAM83D mRNA

NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192

Fas

Fas cell surface death receptor

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of TCF7 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FAS mRNA]

PMID:28318631 PMID:33632240

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

Fgf1

fibroblast growth factor 1

decreases expression

Niclosamide results in decreased expression of FGF1 mRNA; Niclosamide results in decreased expression of FGF1 protein

PMID:25174399

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

Fkbp5

FKBP prolyl isomerase 5

multiple interactions
decreases expression

[Niclosamide co-treated with bicalutamide] results in decreased expression of FKBP5 mRNA
Niclosamide results in decreased expression of FKBP5 mRNA

PMID:28500234

NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674

Fn1

fibronectin 1

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

Fos

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

Fosb

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

Niclosamide results in increased expression of FOSB mRNA

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

Fosl1

FOS like 1, AP-1 transcription factor subunit

increases expression

Niclosamide results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

Foxm1

forkhead box M1

multiple interactions
decreases expression

Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of FOXM1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of FOXM1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of FOXM1 protein]

PMID:27492973

NCBI chr 4:161,639,561...161,652,012
Ensembl chr 4:161,638,816...161,650,684

Fscn1

fascin actin-bundling protein 1

multiple interactions

Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of FSCN1 mRNA]

PMID:29733962

NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211

Fzd1

frizzled class receptor 1

affects localization

Niclosamide affects the localization of FZD1 protein

PMID:19772353

NCBI chr 4:29,310,303...29,314,701

Fzd2

frizzled class receptor 2

decreases expression

Niclosamide results in decreased expression of FZD2 mRNA

NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334

Fzd5

frizzled class receptor 5

increases expression

Niclosamide results in increased expression of FZD5 mRNA

NCBI chr 9:66,117,370...66,119,127
Ensembl chr 9:66,113,112...66,121,457

Fzd9

frizzled class receptor 9

decreases expression

Niclosamide results in decreased expression of FZD9 mRNA

NCBI chr12:21,427,084...21,429,398
Ensembl chr12:21,427,084...21,429,398

Gcg

glucagon

multiple interactions

Niclosamide inhibits the reaction [GCG protein results in increased abundance of Cyclic AMP]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]

PMID:26964897

NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929

Got2

glutamic-oxaloacetic transaminase 2

increases expression

Niclosamide results in increased expression of GOT2 mRNA

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

Gsk3b

glycogen synthase kinase 3 beta

decreases expression
decreases phosphorylation

Niclosamide results in decreased expression of GSK3B mRNA
Niclosamide results in decreased phosphorylation of GSK3B protein

PMID:22576131 PMID:30143678

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

Gtse1

G-2 and S-phase expressed 1

decreases expression

Niclosamide results in decreased expression of GTSE1 mRNA

NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806

Hadh

hydroxyacyl-CoA dehydrogenase

decreases expression

Niclosamide results in decreased expression of HADH mRNA

NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353

Hamp

hepcidin antimicrobial peptide

decreases expression
increases expression

Niclosamide results in decreased expression of HAMP mRNA
Niclosamide results in increased expression of HAMP mRNA

PMID:25633564 PMID:28284560

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

Hbp1

HMG-box transcription factor 1

multiple interactions

Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]

NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787

Hes1

hes family bHLH transcription factor 1

decreases expression
multiple interactions

Niclosamide results in decreased expression of HES1 protein
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HES1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HES1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]]

PMID:19160421 PMID:28318631 PMID:32961231

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

Hey1

hes-related family bHLH transcription factor with YRPW motif 1

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY1 mRNA]
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]

PMID:27542212 PMID:28318631

NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312

Hey2

hes-related family bHLH transcription factor with YRPW motif 2

multiple interactions
increases expression

Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY2 mRNA]
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY2 mRNA]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA]

PMID:19160421 PMID:28318631

NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218

Hif1a

hypoxia inducible factor 1 subunit alpha

decreases expression
multiple interactions

Niclosamide results in decreased expression of HIF1A mRNA; Niclosamide results in decreased expression of HIF1A protein
Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]

PMID:30779072

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

Hipk2

homeodomain interacting protein kinase 2

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 protein]
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]

NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223

Hmmr

hyaluronan-mediated motility receptor

decreases expression

Niclosamide results in decreased expression of HMMR mRNA

NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060

Hoxa1

homeobox A1

increases expression

Niclosamide results in increased expression of HOXA1

PMID:26820057

NCBI chr 4:81,255,814...81,258,504
Ensembl chr 4:81,255,883...81,258,504

Icam1

intercellular adhesion molecule 1

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ICAM1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of ICAM1 mRNA]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

Igf1r

insulin-like growth factor 1 receptor

affects response to substance

IGF1R protein affects the susceptibility to Niclosamide

PMID:27497986

NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777

Ikbkb

inhibitor of nuclear factor kappa B kinase subunit beta

affects localization

Niclosamide affects the localization of IKBKB protein

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

Ikbkg

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

affects localization

Niclosamide affects the localization of IKBKG protein

NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499

Il12a

interleukin 12A

multiple interactions

Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]

PMID:26297436

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

Il1b

interleukin 1 beta

multiple interactions

Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]

PMID:33524445

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il21

interleukin 21

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL21 protein]

NCBI chr 2:120,119,598...120,126,941
Ensembl chr 2:120,119,444...120,126,996

Il6

interleukin 6

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL6 protein]
Niclosamide inhibits the reaction [IL6 protein results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of APPA mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of MYC protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of SOCS1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of TGFB1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]

PMID:24561310 PMID:25970160 PMID:26297436 PMID:28318631 PMID:33632240

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Itgav

integrin subunit alpha V

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGAV mRNA]

PMID:26792726

NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639

Itgb3

integrin subunit beta 3

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

Jun

Jun proto-oncogene, AP-1 transcription factor subunit

affects localization
multiple interactions
increases phosphorylation
increases expression

Niclosamide affects the localization of JUN protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]]; Acetylcysteine inhibits the reaction [Niclosamide results in increased phosphorylation of JUN protein]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]
Niclosamide results in increased expression of JUN mRNA

PMID:24750999 PMID:27338550

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

Kif11

kinesin family member 11

decreases expression

Niclosamide results in decreased expression of KIF11 mRNA

NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766

Kif20a

kinesin family member 20A

decreases expression

Niclosamide results in decreased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

Kifc1

kinesin family member C1

decreases expression

Niclosamide results in decreased expression of KIFC1 mRNA

NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105

Lcat

lecithin cholesterol acyltransferase

increases expression

Niclosamide results in increased expression of LCAT mRNA

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

Ldha

lactate dehydrogenase A

increases expression

Niclosamide results in increased expression of LDHA mRNA

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

Lrp5

LDL receptor related protein 5

multiple interactions

Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]]

PMID:32961231

NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581

Lrp6

LDL receptor related protein 6

decreases expression
multiple interactions

Niclosamide analog results in decreased expression of LRP6 protein; Niclosamide results in decreased expression of LRP6 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]]
Niclosamide results in decreased expression of and results in decreased phosphorylation of LRP6 protein

PMID:24552774 PMID:24736023 PMID:28284560 PMID:32961231

NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497

Mad2l1

mitotic arrest deficient 2 like 1

decreases expression

Niclosamide results in decreased expression of MAD2L1 mRNA

NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470

Map1lc3b

microtubule-associated protein 1 light chain 3 beta

increases expression

Niclosamide results in increased expression of MAP1LC3B protein modified form

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

Mapk1

mitogen activated protein kinase 1

decreases phosphorylation
multiple interactions

Niclosamide results in decreased phosphorylation of MAPK1 protein
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]

PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

Mapk3

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Niclosamide results in decreased phosphorylation of MAPK3 protein

PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Mapk8

mitogen-activated protein kinase 8

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

Mapk9

mitogen-activated protein kinase 9

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

Mcl1

MCL1 apoptosis regulator, BCL2 family member

decreases expression

Niclosamide results in decreased expression of MCL1 protein

PMID:20215516 PMID:26116531

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

Mcm2

minichromosome maintenance complex component 2

decreases expression

Niclosamide results in decreased expression of MCM2 mRNA; Niclosamide results in decreased expression of MCM2 protein

PMID:28284560 PMID:29031202

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

Mcm7

minichromosome maintenance complex component 7

decreases expression

Niclosamide results in decreased expression of MCM7 protein

PMID:29031202

NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063

Met

MET proto-oncogene, receptor tyrosine kinase

decreases expression

Niclosamide results in decreased expression of MET mRNA

PMID:27338550

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

Mki67

marker of proliferation Ki-67

decreases expression

Niclosamide results in decreased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

Mme

membrane metallo-endopeptidase

decreases expression

Niclosamide results in decreased expression of MME mRNA; Niclosamide results in decreased expression of MME protein

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

Mmp2

matrix metallopeptidase 2

decreases expression

Niclosamide results in decreased expression of MMP2 mRNA; Niclosamide results in decreased expression of MMP2 protein

PMID:29251334 PMID:30143678

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

Mmp7

matrix metallopeptidase 7

multiple interactions
decreases expression

Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of MMP7 mRNA]
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of MMP7 mRNA]
Niclosamide results in decreased expression of MMP7 mRNA

PMID:27338550 PMID:28318631

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

Mmp9

matrix metallopeptidase 9

decreases expression
multiple interactions

Niclosamide results in decreased expression of MMP9 mRNA; Niclosamide results in decreased expression of MMP9 protein
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]

PMID:28824321 PMID:29480568 PMID:30143678

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

Mt2A

metallothionein 2A

increases expression

Niclosamide results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

Mtor

mechanistic target of rapamycin kinase

decreases phosphorylation
multiple interactions
increases expression

Niclosamide analog results in decreased phosphorylation of MTOR protein; Niclosamide results in decreased phosphorylation of MTOR protein
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of MTOR protein]; Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]
Niclosamide results in increased expression of MTOR mRNA

PMID:19771169 PMID:26643609 PMID:26703449 PMID:28284560 PMID:29843133

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

Myc

MYC proto-oncogene, bHLH transcription factor

multiple interactions
decreases expression

Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]
Niclosamide results in decreased expression of MYC mRNA; Niclosamide results in decreased expression of MYC protein
[Niclosamide binds to Polyethyleneimine] which results in increased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC protein; enzalutamide promotes the reaction [Niclosamide results in decreased expression of MYC protein]; Niclosamide inhibits the reaction [bicalutamide results in increased expression of MYC protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of MYC protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of MYC mRNA]

PMID:19160421 PMID:20215516 PMID:22576131 PMID:25970160 PMID:25988281 More...

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

Ndufa10

NADH:ubiquinone oxidoreductase subunit A10

decreases expression

Niclosamide results in decreased expression of NDUFA10 mRNA

NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560

Ndufa4l2

NDUFA4, mitochondrial complex associated like 2

increases expression

Niclosamide results in increased expression of NDUFA4L2 mRNA

NCBI chr 7:63,351,021...63,359,010
Ensembl chr 7:63,356,883...63,359,010

Ndufa7

NADH:ubiquinone oxidoreductase subunit A7

decreases expression

Niclosamide results in decreased expression of NDUFA7 mRNA

NCBI chr 7:14,609,283...14,622,064
Ensembl chr 7:14,609,146...14,631,976

Ndufa8

NADH:ubiquinone oxidoreductase subunit A8

decreases expression

Niclosamide results in decreased expression of NDUFA8 mRNA

NCBI chr 3:19,386,063...19,402,093
Ensembl chr 3:19,386,065...19,402,071

Ndufb10

NADH:ubiquinone oxidoreductase subunit B10

decreases expression

Niclosamide results in decreased expression of NDUFB10 mRNA

NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442

Ndufb6

NADH:ubiquinone oxidoreductase subunit B6

decreases expression

Niclosamide results in decreased expression of NDUFB6 mRNA

NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181

Ndufc1

NADH:ubiquinone oxidoreductase subunit C1

increases expression

Niclosamide results in increased expression of NDUFC1 mRNA

NCBI chr 2:135,447,067...135,450,950
Ensembl chr 2:135,447,119...135,450,874

Ndufs2

NADH:ubiquinone oxidoreductase core subunit S2

decreases expression

Niclosamide results in decreased expression of NDUFS2 mRNA

NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420

Ndufs3

NADH:ubiquinone oxidoreductase core subunit S3

decreases expression

Niclosamide results in decreased expression of NDUFS3 mRNA

NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824

Ndufs7

NADH:ubiquinone oxidoreductase core subunit S7

decreases expression

Niclosamide results in decreased expression of NDUFS7 mRNA

NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195

Ndufs8

NADH:ubiquinone oxidoreductase core subunit S8

decreases expression

Niclosamide results in decreased expression of NDUFS8 mRNA

NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511

Ndufv3

NADH:ubiquinone oxidoreductase subunit V3

increases expression

Niclosamide results in increased expression of NDUFV3 mRNA

NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074

Nfatc1

nuclear factor of activated T-cells 1

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]

NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028

Nfkb1

nuclear factor kappa B subunit 1

affects localization

Niclosamide affects the localization of NFKB1 protein

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

Nfkbia

NFKB inhibitor alpha

decreases phosphorylation
multiple interactions

Niclosamide results in decreased phosphorylation of NFKBIA protein
Niclosamide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Niclosamide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Niclosamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]

PMID:20215516 PMID:26116531 PMID:27492973 PMID:28824321 PMID:33524445

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

Nkd1

NKD inhibitor of WNT signaling pathway 1

multiple interactions
increases expression

Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of NKD1 mRNA]
Niclosamide results in increased expression of NKD1 mRNA

PMID:22576131 PMID:24534281

NCBI chr19:18,476,344...18,549,380
Ensembl chr19:18,476,344...18,549,380

Nkx3-1

NK3 homeobox 1

multiple interactions
decreases expression

[Niclosamide co-treated with bicalutamide] results in decreased expression of NKX3-1 mRNA
Niclosamide results in decreased expression of NKX3-1 mRNA

PMID:28500234

NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441

Nlrp3

NLR family, pyrin domain containing 3

multiple interactions

Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein]

PMID:33524445

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

Notch1

notch receptor 1

decreases activity
multiple interactions

Niclosamide results in decreased activity of NOTCH1 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]]

PMID:19160421 PMID:32961231

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

Nr1i3

nuclear receptor subfamily 1, group I, member 3

multiple interactions

Niclosamide binds to and results in increased activity of NR1I3 protein alternative form

PMID:31312845

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

Ocstamp

osteoclast stimulatory transmembrane protein

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]

NCBI chr 3:154,131,113...154,141,611
Ensembl chr 3:154,132,328...154,136,991

Orc1

origin recognition complex, subunit 1

decreases expression

Niclosamide results in decreased expression of ORC1 mRNA

NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375

Oscar

osteoclast associated Ig-like receptor

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]

NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758

Parp1

poly (ADP-ribose) polymerase 1

multiple interactions
decreases expression
increases expression
increases cleavage

[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased cleavage of PARP1 protein
Niclosamide results in decreased expression of PARP1 protein
Niclosamide results in increased expression of PARP1 protein modified form
Niclosamide results in increased cleavage of PARP1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Niclosamide results in increased cleavage of PARP1 protein]; bicalutamide promotes the reaction [Niclosamide results in increased expression of PARP1 protein modified form]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]

PMID:24750999 PMID:25174399 PMID:26917416 PMID:28500234 PMID:30258081 More...

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

pyruvate carboxylase

increases expression

Niclosamide results in increased expression of PC mRNA

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380

Pfkm

phosphofructokinase, muscle

decreases expression

Niclosamide results in decreased expression of PFKM mRNA

NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192

Phlda1

pleckstrin homology-like domain, family A, member 1

increases expression

Niclosamide results in increased expression of PHLDA1 mRNA

NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861

Pik3ca

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

increases expression
multiple interactions

Niclosamide results in increased expression of PIK3CA mRNA
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CXCL8 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA]

PMID:27542212 PMID:29843133

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

Pkm

pyruvate kinase M1/2

increases expression

Niclosamide results in increased expression of PKM mRNA

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

Pou5f1

POU class 5 homeobox 1

decreases phosphorylation

Niclosamide results in decreased phosphorylation of POU5F1 protein

PMID:23333246

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

Ppard

peroxisome proliferator-activated receptor delta

increases expression

Niclosamide results in increased expression of PPARD mRNA

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

Ppp2cb

protein phosphatase 2 catalytic subunit beta

decreases expression

Niclosamide results in decreased expression of PPP2CB mRNA

NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576

Ppp2r1a

protein phosphatase 2 scaffold subunit A alpha

increases expression

Niclosamide results in increased expression of PPP2R1A mRNA

NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129

Ppp2r1b

protein phosphatase 2 scaffold subunit A beta

multiple interactions

Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA]

NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485

Ppp2r2b

protein phosphatase 2, regulatory subunit B, beta

decreases expression

Niclosamide results in decreased expression of PPP2R2B mRNA

NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025

Ppp2r2c

protein phosphatase 2, regulatory subunit B, gamma

decreases expression

Niclosamide results in decreased expression of PPP2R2C mRNA

NCBI chr14:73,846,547...73,931,178
Ensembl chr14:73,846,547...73,931,864

Prdm1

PR/SET domain 1

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA]

NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488

Prkcq

protein kinase C, theta

increases expression

Niclosamide results in increased expression of PRKCQ mRNA

NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704

Pten

phosphatase and tensin homolog

increases expression

Niclosamide results in increased expression of PTEN mRNA

PMID:29843133

NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838

Rad54l

RAD54 like

increases expression

Niclosamide results in increased expression of RAD54L mRNA

NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070

Raf1

Raf-1 proto-oncogene, serine/threonine kinase

decreases phosphorylation
decreases expression

Niclosamide analog results in decreased phosphorylation of RAF1 protein
Niclosamide analog results in decreased expression of RAF1 protein; Niclosamide results in decreased expression of RAF1 protein

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

Rela

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases expression

Niclosamide affects the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of and results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of RELA protein modified form]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of RELA protein modified form]
Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of RELA protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of RELA protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of RELA protein]; Niclosamide results in decreased phosphorylation of and affects the localization of RELA protein

PMID:20215516 PMID:26116531 PMID:26643609 PMID:27492973 PMID:28318631 More...

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

Rhof

ras homolog family member F, filopodia associated

multiple interactions

Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of RHOF mRNA]

PMID:29733962

NCBI chr12:33,422,375...33,446,689
Ensembl chr12:33,431,280...33,446,703

Ripor3

RIPOR family member 3

increases expression

Niclosamide results in increased expression of FAM65C mRNA

NCBI chr 3:156,687,253...156,760,524
Ensembl chr 3:156,687,517...156,715,061

Rock1

Rho-associated coiled-coil containing protein kinase 1

decreases expression

Niclosamide results in decreased expression of ROCK1 mRNA; Niclosamide results in decreased expression of ROCK1 protein

PMID:29251334

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

Rps6

ribosomal protein S6

affects phosphorylation

Niclosamide affects the phosphorylation of RPS6 protein

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

Rps6kb1

ribosomal protein S6 kinase B1

decreases phosphorylation

Niclosamide results in decreased phosphorylation of RPS6KB1 protein

PMID:27542212 PMID:30258081

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

Rrm2

ribonucleotide reductase regulatory subunit M2

decreases expression

Niclosamide results in decreased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

Runx2

RUNX family transcription factor 2

decreases expression

Niclosamide results in decreased expression of RUNX2 mRNA

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

S100a4

S100 calcium-binding protein A4

decreases expression
multiple interactions

Niclosamide results in decreased expression of S100A4 mRNA; Niclosamide results in decreased expression of S100A4 protein
Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of S100A4 protein]

PMID:21685359 PMID:29733962

NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254

Serpine1

serpin family E member 1

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of SERPINE1 mRNA]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

Serpine2

serpin family E member 2

multiple interactions

Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE2 mRNA]

NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826

Slc2a1

solute carrier family 2 member 1

decreases expression

Niclosamide results in decreased expression of SLC2A1 mRNA

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

Slc2a3

solute carrier family 2 member 3

decreases expression

Niclosamide results in decreased expression of SLC2A3 mRNA

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

Smad3

SMAD family member 3

multiple interactions

HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
Niclosamide inhibits the reaction [Doxorubicin results in increased phosphorylation of SMAD3 protein]

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

Snai1

snail family transcriptional repressor 1

multiple interactions
decreases expression

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of SNAI1 mRNA]
Niclosamide results in decreased expression of SNAI1 mRNA; Niclosamide results in decreased expression of SNAI1 protein
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of SNAI1 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]

PMID:26643609 PMID:28318631 PMID:30143678

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

Snai2

snail family transcriptional repressor 2

multiple interactions
decreases expression

WNT7A protein affects the reaction [Niclosamide results in increased expression of SNAI2 protein]
Niclosamide results in decreased expression of SNAI2 protein

PMID:25174399

NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200

Src

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of SRC protein]

PMID:26643609

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

Stat3

signal transducer and activator of transcription 3

decreases phosphorylation
multiple interactions
decreases expression

Niclosamide analog results in decreased phosphorylation of STAT3 protein; Niclosamide results in decreased phosphorylation of STAT3 protein
Niclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein]
[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; enzalutamide promotes the reaction [Niclosamide results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Niclosamide inhibits the reaction [STAT3 protein results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of STAT3 protein]; Niclosamide results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of STAT3 protein; Niclosamide results in decreased expression of and results in decreased phosphorylation of STAT3 protein
Niclosamide analog results in decreased expression of STAT3 protein; Niclosamide results in decreased expression of STAT3 protein

PMID:23333246 PMID:23894143 PMID:24552774 PMID:25970160 PMID:26116531 More...

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

Tacc3

transforming, acidic coiled-coil containing protein 3

decreases expression

Niclosamide results in decreased expression of TACC3 mRNA

NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219

Tcf7

transcription factor 7

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of TCF7 protein]

NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535

Tcim

transcriptional and immune response regulator

increases expression

Niclosamide results in increased expression of TCIM mRNA

NCBI chr16:67,595,762...67,597,055
Ensembl chr16:67,593,410...67,597,581

Tgfb1

transforming growth factor, beta 1

multiple interactions

HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL20 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FAS mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HES1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of ICAM1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of MMP7 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of RELA protein modified form]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

Timp2

TIMP metallopeptidase inhibitor 2

increases expression

Niclosamide results in increased expression of TIMP2 mRNA

PMID:30143678

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

Tk1

thymidine kinase 1

decreases expression

Niclosamide results in decreased expression of TK1 mRNA

NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920

Tnf

tumor necrosis factor

multiple interactions
decreases activity

Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF mRNA]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of FOXM1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of MYC mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
Niclosamide results in decreased activity of TNF protein

PMID:20215516 PMID:24561310 PMID:27492973 PMID:28318631 PMID:33524445

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tnfsf11

TNF superfamily member 11

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGAV mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of STAT3 protein]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]

NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445

Tp53

tumor protein p53

multiple interactions
increases expression
decreases response to substance
increases response to substance

[Niclosamide binds to Polyethyleneimine] which results in increased expression of TP53 mRNA; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of BBC3 mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP3 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]
[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of adrenic acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Arachidonic Acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Docosahexaenoic Acids; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Eicosapentaenoic Acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Lysophosphatidylcholines; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of lysophosphatidylethanolamine; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased cleavage of PARP1 protein; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased expression of CASP3 protein modified form
Niclosamide results in increased expression of TP53 mRNA; Niclosamide results in increased expression of TP53 protein
TP53 protein results in decreased susceptibility to Niclosamide
TP53 gene mutant form results in increased susceptibility to Niclosamide; TP53 protein mutant form results in increased susceptibility to Niclosamide
Niclosamide results in increased expression of TRP53 protein

PMID:22576131 PMID:25988281 PMID:29031202 PMID:30258081

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

Tpi1

triosephosphate isomerase 1

increases expression

Niclosamide results in increased expression of TPI1 mRNA

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

Tpx2

TPX2, microtubule nucleation factor

decreases expression

Niclosamide results in decreased expression of TPX2 mRNA

NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468

Traf6

TNF receptor associated factor 6

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

Trip13

thyroid hormone receptor interactor 13

decreases expression

Niclosamide results in decreased expression of TRIP13 mRNA

NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074

Twist1

twist family bHLH transcription factor 1

decreases expression

Niclosamide results in decreased expression of TWIST1 protein

NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653

Ube2c

ubiquitin-conjugating enzyme E2C

multiple interactions
decreases expression

[Niclosamide co-treated with bicalutamide] results in decreased expression of UBE2C mRNA
Niclosamide results in decreased expression of UBE2C mRNA

PMID:28500234

NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339

Uhrf1

ubiquitin-like with PHD and ring finger domains 1

decreases expression

Niclosamide results in decreased expression of UHRF1 mRNA

NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631

Utp3

UTP3, small subunit processome component

decreases expression

Niclosamide results in decreased expression of UTP3 mRNA

PMID:27226553

NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396

Vegfa

vascular endothelial growth factor A

decreases expression

Niclosamide results in decreased expression of VEGFA mRNA; Niclosamide results in decreased expression of VEGFA protein

PMID:29251334

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

Vim

vimentin

multiple interactions
decreases expression

HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of VIM protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]
Niclosamide results in decreased expression of VIM mRNA; Niclosamide results in decreased expression of VIM protein

PMID:26643609 PMID:28318631 PMID:30143678

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

Vpreb1

V-set pre-B cell surrogate light chain 1

decreases expression

Niclosamide results in decreased expression of VPREB1 mRNA

PMID:27226553

NCBI chr11:84,126,969...84,127,846
Ensembl chr11:84,126,969...84,127,846

Wnt2b

Wnt family member 2B

decreases expression

Niclosamide results in decreased expression of WNT2B mRNA

NCBI chr 2:192,454,226...192,468,599
Ensembl chr 2:192,453,824...192,470,308

Wnt3

Wnt family member 3

decreases expression

Niclosamide results in decreased expression of WNT3 mRNA

NCBI chr10:88,680,248...88,724,170
Ensembl chr10:88,680,248...88,724,099

Wnt3a

Wnt family member 3A

multiple interactions
decreases expression

Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein]
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of WNT3A mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of WNT3A mRNA]]
Niclosamide results in decreased expression of WNT3A mRNA

PMID:19772353 PMID:22576131 PMID:27492973 PMID:32961231

NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324

Wnt7a

Wnt family member 7A

increases response to substance
multiple interactions
decreases activity

WNT7A protein results in increased susceptibility to Niclosamide
WNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of SNAI2 protein]
Niclosamide results in decreased activity of WNT7A protein

PMID:25174399

NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981

Xiap

X-linked inhibitor of apoptosis

decreases expression

Niclosamide results in decreased expression of XIAP protein

PMID:20215516

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

Zfp36

zinc finger protein 36

increases expression

Niclosamide results in increased expression of ZFP36 mRNA

NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564

Zic2

Zic family member 2

increases expression

Niclosamide results in increased expression of ZIC2 mRNA

NCBI chr15:99,576,697...99,581,522
Ensembl chr15:99,576,697...99,581,522

S3I-201

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Jak2

Janus kinase 2

multiple interactions

S3I-201 inhibits the reaction [Rapamycin increases phosphorylation of JAK2 protein in lung epithelium]

RGD

PMID:30755242

RGD:149735343

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

stattic

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Akt1

AKT serine/threonine kinase 1

multiple interactions

stattic inhibits the reaction [Arsenicals results in increased phosphorylation of AKT1 protein]

PMID:23255093

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

Bcl2

BCL2, apoptosis regulator

decreases expression

stattic results in decreased expression of BCL2 protein

PMID:24627483 PMID:25611565

NCBI chr13:22,689,783...22,853,920

Bcl2l1

Bcl2-like 1

multiple interactions

stattic inhibits the reaction [glycine-extended gastrin 17 results in increased expression of BCL2L1 mRNA]

PMID:19153190

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

Birc5

baculoviral IAP repeat-containing 5

multiple interactions

stattic inhibits the reaction [glycine-extended gastrin 17 results in increased expression of BIRC5 mRNA]

PMID:19153190

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

Ccn2

cellular communication network factor 2

multiple interactions

stattic inhibits the reaction [IL6 protein results in increased expression of CCN2 mRNA]
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCN2 mRNA]

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

Ccnd1

cyclin D1

multiple interactions

stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 protein]
stattic affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]

PMID:30670587 PMID:33396024

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

Cd44

CD44 molecule (Indian blood group)

multiple interactions

stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]]

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

Cdh1

cadherin 1

multiple interactions

stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 mRNA]]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

Cish

cytokine inducible SH2-containing protein

multiple interactions

stattic inhibits the reaction [IL6 protein results in increased expression of CISH mRNA]

PMID:26297436

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

Col1a1

collagen type I alpha 1 chain

multiple interactions

stattic inhibits the reaction [IL6 protein results in increased expression of COL1A1 mRNA]
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A1 mRNA]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

Edn1

endothelin 1

multiple interactions

stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 protein]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 protein]

PMID:30670587

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

Egf

epidermal growth factor

multiple interactions

stattic inhibits the reaction [EGF protein results in increased expression of PSMB5 protein]; stattic inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]

NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064

Ezh2

enhancer of zeste 2 polycomb repressive complex 2 subunit

multiple interactions

stattic inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein]

PMID:23255093

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

Gpt

glutamic--pyruvic transaminase

multiple interactions

stattic inhibits the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GPT protein]

PMID:28887131

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

Hif1a

hypoxia inducible factor 1 subunit alpha

multiple interactions

stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A protein]

PMID:29341321

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

Icam1

intercellular adhesion molecule 1

multiple interactions

stattic inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]

PMID:29329563

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

Il12a

interleukin 12A

multiple interactions

stattic inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]

PMID:26297436

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

Il1b

interleukin 1 beta

multiple interactions

stattic inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il6

interleukin 6

multiple interactions

[stattic co-treated with IL6 protein] results in increased expression of SOCS3 protein; stattic affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein]; stattic inhibits the reaction [IL6 protein results in increased activity of TGFB1 protein]; stattic inhibits the reaction [IL6 protein results in increased expression of APPA mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of CCN2 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of CISH mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of COL1A1 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A protein]; stattic inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
stattic inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]; stattic inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of IL6 mRNA]

PMID:22454431 PMID:25740948 PMID:26297436 PMID:28739487 PMID:29341321

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Jak2

Janus kinase 2

multiple interactions

stattic inhibits the reaction [deoxynivalenol results in increased expression of JAK2 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of JAK2 mRNA]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

Mapk9

mitogen-activated protein kinase 9

multiple interactions

stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein]

PMID:24434654

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

Mir21

microRNA 21

affects expression
multiple interactions

stattic affects the expression of MIR21 mRNA
stattic affects the reaction [arsenic trichloride affects the expression of MIR21 mRNA]

PMID:24434654

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

Mmp10

matrix metallopeptidase 10

decreases expression

stattic results in decreased expression of MMP10 mRNA

PMID:22285823

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

Mpo

myeloperoxidase

multiple interactions

stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819

Pcna

proliferating cell nuclear antigen

multiple interactions

stattic affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; stattic affects the reaction [CXCL8 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

Psmb1

proteasome 20S subunit beta 1

decreases expression

stattic results in decreased expression of PSMB1 mRNA; stattic results in decreased expression of PSMB1 protein

NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560

Psmb2

proteasome 20S subunit beta 2

decreases expression

stattic results in decreased expression of PSMB2 mRNA; stattic results in decreased expression of PSMB2 protein

NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137

Psmb3

proteasome 20S subunit beta 3

decreases expression

stattic results in decreased expression of PSMB3 mRNA; stattic results in decreased expression of PSMB3 protein

NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521

Psmb4

proteasome 20S subunit beta 4

decreases expression

stattic results in decreased expression of PSMB4 mRNA; stattic results in decreased expression of PSMB4 protein

NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746

Psmb5

proteasome 20S subunit beta 5

decreases expression
multiple interactions

stattic results in decreased expression of PSMB5 mRNA; stattic results in decreased expression of PSMB5 protein
stattic inhibits the reaction [EGF protein results in increased expression of PSMB5 protein]

NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440

Psmb6

proteasome 20S subunit beta 6

decreases expression

stattic results in decreased expression of PSMB6 mRNA; stattic results in decreased expression of PSMB6 protein

NCBI chr10:55,239,274...55,241,581
Ensembl chr10:55,239,241...55,241,586

Psmb7

proteasome 20S subunit beta 7

decreases expression

stattic results in decreased expression of PSMB7 mRNA; stattic results in decreased expression of PSMB7 protein

NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937

Riox2

ribosomal oxygenase 2

multiple interactions

stattic inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of RIOX2 protein]

PMID:24434654

NCBI chr11:40,861,365...40,884,782
Ensembl chr11:40,860,774...40,884,574

Skp2

S-phase kinase associated protein 2

multiple interactions

stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 protein]

PMID:30670587

NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338

Snai1

snail family transcriptional repressor 1

multiple interactions

stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 mRNA]]

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

Snai2

snail family transcriptional repressor 2

multiple interactions

stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 mRNA]]

NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200

Socs3

suppressor of cytokine signaling 3

multiple interactions

[stattic co-treated with IL6 protein] results in increased expression of SOCS3 protein

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

Stat1

signal transducer and activator of transcription 1

multiple interactions

stattic inhibits the reaction [deoxynivalenol results in increased expression of STAT1 mRNA]; stattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT1 protein]; stattic inhibits the reaction [T-2 Toxin results in increased expression of STAT1 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT1 protein]

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

Stat3

signal transducer and activator of transcription 3

multiple interactions
decreases phosphorylation

stattic affects the reaction [Arsenicals affects the phosphorylation of STAT3 protein]; stattic affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein]; stattic inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
Stattic inhibits the reaction [Il-6 increases phosphorylation of STAT3 protein in the stomach)
stattic inhibits the reaction [zoniporide results in increased phosphorylation of STAT3 protein]
stattic inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [deoxynivalenol results in increased expression of STAT3 mRNA]; stattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [T-2 Toxin results in increased expression of STAT3 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein]
stattic results in decreased phosphorylation of STAT3 protein

CTD
RGD

PMID:20942815 PMID:22454431 PMID:23255093 PMID:24627483 PMID:25740948 More...

RGD:127284846

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

Tgfb1

transforming growth factor, beta 1

multiple interactions

stattic inhibits the reaction [IL6 protein results in increased activity of TGFB1 protein]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1 mRNA]
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TGFB1 mRNA]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

Tnf

tumor necrosis factor

multiple interactions

stattic inhibits the reaction [deoxynivalenol results in increased expression of TNF mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of TNF mRNA]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Twist1

twist family bHLH transcription factor 1

multiple interactions

stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 mRNA]]

NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653

Vim

vimentin

multiple interactions

stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM mRNA]]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

tyrphostin B42

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Birc5

baculoviral IAP repeat-containing 5

decreases expression

tyrphostin B42 alone or co-treated with Nimesulide decreases expression of BIRC5 protein in esophagus squamous epithelium

RGD

PMID:25724470

RGD:127285656

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

Casp3

caspase 3

multiple interactions

tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases cleavage of CASP3 protein in stomach]

RGD

PMID:32106377

RGD:127284886

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Casp9

caspase 9

multiple interactions

tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid decreases cleavage of CASP9 protein in stomach]

RGD

PMID:32106377

RGD:127284886

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

Jak2

Janus kinase 2

decreases expression
multiple interactions

PMID:26385087 PMID:31250048 PMID:30706361 PMID:22050790 PMID:32106377

Turphostin B42 decreased expression of Jak2 mRNA in myofibroblasts
tyrphostin B42 inhibits the reaction [cisplatin increases expression of Jak2 mRNA in kidney]
tyrphostin B42 inhibits the reaction [selumetinib increases phosphorylation of JAK2 protein in colonic epithelium]
tyrphostin B42 decreases expression and phosphorylation of JAK2 protein in colonic epithelium
tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases phosphorylation of JAK2 protein in stomach]

RGD

RGD:18337263, RGD:149735351, RGD:127285668, RGD:127285665, RGD:127284886

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

Mt-co2

mitochondrially encoded cytochrome c oxidase II

decreases expression

Tyrphostin B42 alone or co-treated with Nimesulide decreases expression of MT-CO2 protein in esophagus squamous epithelium

RGD

PMID:25724470

RGD:127285656

NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689

Stat3

signal transducer and activator of transcription 3

multiple interactions