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G |
Acaca |
acetyl-CoA carboxylase alpha |
decreases expression |
ISO |
Niclosamide results in decreased expression of ACACA mRNA |
CTD |
PMID:22576131 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Acp5 |
acid phosphatase 5, tartrate resistant |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA] |
CTD |
PMID:26792726 PMID:28824321 |
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NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
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G |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of ACSL1 mRNA |
CTD |
PMID:22576131 |
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NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ACTA2 protein] Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of ACTA2 protein] |
CTD |
PMID:26643609 PMID:28318631 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adh4 |
alcohol dehydrogenase 4 (class II), pi polypeptide |
decreases expression |
ISO |
Niclosamide results in decreased expression of ADH4 mRNA |
CTD |
PMID:28284560 |
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NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
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G |
Afp |
alpha-fetoprotein |
multiple interactions |
EXP |
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]] |
CTD |
PMID:32961231 |
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NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
increases cleavage |
ISO |
Niclosamide results in increased cleavage of AIFM1 protein |
CTD |
PMID:22576131 |
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NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases expression multiple interactions |
ISO |
Niclosamide results in increased expression of AKT1 mRNA Niclosamide inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:20215516 PMID:26792726 PMID:29843133 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of ALDH1A1 protein |
CTD |
PMID:24736023 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldob |
aldolase, fructose-bisphosphate B |
increases expression |
ISO |
Niclosamide results in increased expression of ALDOB mRNA |
CTD |
PMID:22576131 |
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NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
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G |
Aldoc |
aldolase, fructose-bisphosphate C |
decreases expression |
ISO |
Niclosamide results in decreased expression of ALDOC mRNA |
CTD |
PMID:22576131 |
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NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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G |
Alox12b |
arachidonate 12-lipoxygenase, 12R type |
increases expression multiple interactions decreases response to substance |
ISO |
Niclosamide results in increased expression of ALOX12B mRNA TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA] ALOX12B protein results in decreased susceptibility to Niclosamide |
CTD |
PMID:30258081 |
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NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938
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G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions decreases response to substance increases expression |
ISO |
TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA] ALOX5 protein results in decreased susceptibility to Niclosamide |
CTD |
PMID:30258081 |
|
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
decreases expression |
ISO |
Niclosamide results in decreased expression of ALPL mRNA |
CTD |
PMID:28824321 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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G |
Apof |
apolipoprotein F |
decreases expression |
ISO |
Niclosamide results in decreased expression of APOF mRNA |
CTD |
PMID:28284560 |
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NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946
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G |
Ar |
androgen receptor |
multiple interactions decreases expression |
ISO |
[enzalutamide co-treated with Niclosamide] results in decreased expression of AR protein; [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]] which results in decreased expression of KLK3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein]; Niclosamide inhibits the reaction [AR protein alternative form binds to KLK3 promoter]; Niclosamide inhibits the reaction [AR protein alternative form results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 protein]; Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]; Niclosamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form Niclosamide results in decreased expression of AR protein; Niclosamide results in decreased expression of AR protein alternative form |
CTD |
PMID:24740322 PMID:25970160 PMID:28500234 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Araf |
A-Raf proto-oncogene, serine/threonine kinase |
decreases expression |
ISO |
Niclosamide analog results in decreased expression of ARAF protein; Niclosamide results in decreased expression of ARAF protein |
CTD |
PMID:28284560 |
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NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073
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G |
Asf1b |
anti-silencing function 1B histone chaperone |
decreases expression |
ISO |
Niclosamide results in decreased expression of ASF1B mRNA |
CTD |
PMID:28284560 |
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NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549
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G |
Atf3 |
activating transcription factor 3 |
increases expression multiple interactions |
ISO |
Niclosamide results in increased expression of ATF3 mRNA; Niclosamide results in increased expression of ATF3 protein ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]; ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA] |
CTD |
PMID:26917416 |
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NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Atf4 |
activating transcription factor 4 |
increases expression |
ISO |
Niclosamide results in increased expression of ATF4 mRNA; Niclosamide results in increased expression of ATF4 protein |
CTD |
PMID:26917416 |
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atp5f1a |
ATP synthase F1 subunit alpha |
increases expression |
ISO |
Niclosamide results in increased expression of ATP5F1A mRNA |
CTD |
PMID:22576131 |
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NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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G |
Atp5f1d |
ATP synthase F1 subunit delta |
increases expression |
ISO |
Niclosamide results in increased expression of ATP5F1D mRNA |
CTD |
PMID:22576131 |
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NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929
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G |
Atp5mc3 |
ATP synthase membrane subunit c locus 3 |
decreases expression |
ISO |
Niclosamide results in decreased expression of ATP5MC3 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279
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G |
Atp5mf |
ATP synthase membrane subunit f |
decreases expression |
ISO |
Niclosamide results in decreased expression of ATP5MF mRNA |
CTD |
PMID:22576131 |
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NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236
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G |
Atp5mg |
ATP synthase membrane subunit g |
decreases expression |
ISO |
Niclosamide results in decreased expression of ATP5MG mRNA |
CTD |
PMID:22576131 |
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NCBI chr 8:45,226,750...45,233,582
Ensembl chr 8:45,225,686...45,233,559
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G |
Atp5pb |
ATP synthase peripheral stalk-membrane subunit b |
decreases expression |
ISO |
Niclosamide results in decreased expression of ATP5PB mRNA |
CTD |
PMID:22576131 |
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NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418
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G |
Atp6ap1 |
ATPase H+ transporting accessory protein 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of ATP6AP1 mRNA |
CTD |
PMID:22576131 |
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NCBI chr X:152,079,954...152,087,034
Ensembl chr X:152,079,865...152,087,034
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G |
Atp6v0d2 |
ATPase H+ transporting V0 subunit D2 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA] |
CTD |
PMID:26792726 |
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NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
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G |
Aurkb |
aurora kinase B |
decreases expression |
ISO |
Niclosamide results in decreased expression of AURKB mRNA |
CTD |
PMID:28284560 |
|
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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G |
Axin2 |
axin 2 |
multiple interactions decreases expression |
ISO |
Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA] Niclosamide results in decreased expression of AXIN2 mRNA; Niclosamide results in decreased expression of AXIN2 protein |
CTD |
PMID:22576131 PMID:24534281 PMID:24552774 PMID:24736023 |
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NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
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G |
Bad |
BCL2-associated agonist of cell death |
multiple interactions |
ISO |
[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAD mRNA |
CTD |
PMID:25988281 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bak1 |
BCL2-antagonist/killer 1 |
multiple interactions |
ISO |
[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAK1 mRNA |
CTD |
PMID:25988281 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions decreases expression |
ISO |
Niclosamide results in increased expression of BAX protein [Niclosamide binds to Polyethyleneimine] which results in increased expression of BAX mRNA; [Niclosamide co-treated with bicalutamide] results in increased expression of BAX protein; bicalutamide inhibits the reaction [Niclosamide results in decreased expression of BAX protein] |
CTD |
PMID:25634333 PMID:25988281 PMID:26703449 PMID:28500234 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bbc3 |
Bcl-2 binding component 3 |
multiple interactions increases expression |
ISO |
TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of BBC3 mRNA] |
CTD |
PMID:30258081 |
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NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO |
Niclosamide analog results in decreased expression of BCL2 protein; Niclosamide results in decreased expression of BCL2 protein [Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2 mRNA; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2 protein] |
CTD |
PMID:20215516 PMID:23894143 PMID:25634333 PMID:25988281 PMID:26116531 PMID:26703449 PMID:28284560 PMID:28500234 More...
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NCBI chr13:22,689,783...22,853,920
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions decreases expression |
ISO |
[Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2L1 mRNA; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2L1 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2L1 protein] Niclosamide analog results in decreased expression of BCL2L1 protein; Niclosamide results in decreased expression of BCL2L1 protein |
CTD |
PMID:20215516 PMID:25988281 PMID:26116531 PMID:28284560 PMID:28500234 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bcl2l2 |
Bcl2-like 2 |
decreases expression multiple interactions |
ISO |
Niclosamide results in decreased expression of BCL2L2 protein [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein] |
CTD |
PMID:23894143 |
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NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
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G |
Bcl6 |
BCL6, transcription repressor |
multiple interactions |
ISO |
Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein] |
CTD |
PMID:33632240 |
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NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
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G |
Bcl9 |
BCL9, transcription coactivator |
decreases expression |
EXP |
Niclosamide results in decreased expression of BCL9 mRNA |
CTD |
PMID:27338550 |
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NCBI chr 2:184,760,616...184,846,261
Ensembl chr 2:184,760,618...184,786,435
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions affects expression decreases expression |
ISO |
enzalutamide promotes the reaction [Niclosamide results in decreased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein] Niclosamide affects the expression of BIRC5 protein Niclosamide analog results in decreased expression of BIRC5 protein; Niclosamide results in decreased expression of BIRC5 protein |
CTD |
PMID:24552774 PMID:24736023 PMID:25970160 PMID:28284560 PMID:28500234 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Braf |
B-Raf proto-oncogene, serine/threonine kinase |
decreases expression decreases phosphorylation |
ISO |
Niclosamide analog results in decreased expression of BRAF protein; Niclosamide results in decreased expression of BRAF protein Niclosamide analog results in decreased phosphorylation of BRAF protein |
CTD |
PMID:28284560 |
|
NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
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G |
Casp1 |
caspase 1 |
multiple interactions |
ISO |
[Niclosamide co-treated with Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CASP1 protein Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein] |
CTD |
PMID:33524445 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
increases cleavage multiple interactions increases expression decreases expression |
ISO EXP |
Niclosamide results in increased cleavage of CASP3 protein Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]] [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased expression of CASP3 protein modified form; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form] Niclosamide results in increased expression of CASP3 protein modified form Niclosamide results in decreased expression of CASP3 protein 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; [Niclosamide binds to Polyethyleneimine] which results in increased expression of CASP3 mRNA; ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP3 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein] |
CTD |
PMID:20215516 PMID:21871175 PMID:24750999 PMID:25174399 PMID:25634333 PMID:25988281 PMID:26116531 PMID:26703449 PMID:26917416 PMID:28824321 PMID:29031202 PMID:30258081 PMID:30329025 PMID:32961231 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
multiple interactions increases expression |
ISO |
bicalutamide promotes the reaction [Niclosamide results in increased expression of CASP7 protein modified form] |
CTD |
PMID:26116531 PMID:28500234 |
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NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp9 |
caspase 9 |
multiple interactions increases expression increases cleavage |
ISO |
TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein] Niclosamide results in increased expression of CASP9 protein modified form |
CTD |
PMID:26116531 PMID:26703449 PMID:30258081 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO EXP |
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL2 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA] |
CTD |
PMID:24561310 PMID:28318631 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl20 |
C-C motif chemokine ligand 20 |
multiple interactions |
ISO EXP |
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL20 mRNA] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL20 mRNA] |
CTD |
PMID:28318631 |
|
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] |
CTD |
PMID:24561310 |
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NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL5 protein] |
CTD |
PMID:24561310 |
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NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of CCNB1 mRNA |
CTD |
PMID:28284560 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression |
EXP ISO |
Niclosamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]] Niclosamide results in decreased expression of CCND1 mRNA Niclosamide analog results in decreased expression of CCND1 protein; Niclosamide results in decreased expression of CCND1 mRNA; Niclosamide results in decreased expression of CCND1 protein Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of CCND1 protein] |
CTD |
PMID:19160421 PMID:20215516 PMID:24552774 PMID:24736023 PMID:26297436 PMID:26964897 PMID:27338550 PMID:28284560 PMID:28500234 PMID:30143678 PMID:32961231 More...
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd2 |
cyclin D2 |
decreases expression increases expression |
ISO |
Niclosamide results in decreased expression of CCND2 mRNA Niclosamide results in increased expression of CCND2 mRNA |
CTD |
PMID:22576131 PMID:27226553 |
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NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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G |
Ccnd3 |
cyclin D3 |
decreases expression |
ISO |
Niclosamide results in decreased expression of CCND3 mRNA |
CTD |
PMID:22576131 PMID:27226553 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccne2 |
cyclin E2 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA] |
CTD |
PMID:27542212 |
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NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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G |
Ccng2 |
cyclin G2 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA] |
CTD |
PMID:27542212 |
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NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
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Cd40 |
CD40 molecule |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD40 protein] |
CTD |
PMID:24561310 |
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NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cd80 |
Cd80 molecule |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD80 protein] |
CTD |
PMID:24561310 |
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NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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Cd86 |
CD86 molecule |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD86 protein] |
CTD |
PMID:24561310 |
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NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Cdc37 |
cell division cycle 37, HSP90 cochaperone |
multiple interactions |
ISO |
CDC37 protein binds to and results in increased susceptibility to Niclosamide analog |
CTD |
PMID:28284560 |
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NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
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G |
Cdc42 |
cell division cycle 42 |
decreases expression decreases phosphorylation |
ISO |
Niclosamide results in decreased expression of CDC42 mRNA Niclosamide results in decreased phosphorylation of CDC42 protein |
CTD |
PMID:29251334 |
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NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
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G |
Cdc6 |
cell division cycle 6 |
decreases expression |
ISO |
Niclosamide results in decreased expression of CDC6 mRNA |
CTD |
PMID:28284560 |
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NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
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G |
Cdca2 |
cell division cycle associated 2 |
decreases expression |
ISO |
Niclosamide results in decreased expression of CDCA2 mRNA |
CTD |
PMID:28284560 |
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NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611
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G |
Cdca5 |
cell division cycle associated 5 |
decreases expression |
ISO |
Niclosamide results in decreased expression of CDCA5 mRNA |
CTD |
PMID:28284560 |
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NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023
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G |
Cdca8 |
cell division cycle associated 8 |
decreases expression |
ISO |
Niclosamide results in decreased expression of CDCA8 mRNA |
CTD |
PMID:28284560 |
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NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629
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G |
Cdh1 |
cadherin 1 |
multiple interactions increases expression |
ISO |
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in decreased expression of CDH1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein] Niclosamide results in increased expression of CDH1 mRNA; Niclosamide results in increased expression of CDH1 protein |
CTD |
PMID:25174399 PMID:26643609 PMID:30143678 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdh2 |
cadherin 2 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of CDH2 protein] |
CTD |
PMID:26643609 |
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NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
Niclosamide results in decreased expression of CDK2 protein |
CTD |
PMID:29031202 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
Niclosamide results in decreased expression of CDK4 protein |
CTD |
PMID:29031202 |
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NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
ISO |
TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA] |
CTD |
PMID:30258081 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn3 |
cyclin-dependent kinase inhibitor 3 |
decreases expression |
ISO |
Niclosamide results in decreased expression of CDKN3 mRNA |
CTD |
PMID:28284560 |
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NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
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G |
Celsr3 |
cadherin, EGF LAG seven-pass G-type receptor 3 |
increases expression |
ISO |
Niclosamide results in increased expression of CELSR3 mRNA |
CTD |
PMID:28284560 |
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NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354
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G |
Cenpa |
centromere protein A |
decreases expression |
ISO |
Niclosamide results in decreased expression of CENPA mRNA |
CTD |
PMID:28284560 |
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NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
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G |
Cfp |
complement factor properdin |
increases expression |
ISO |
Niclosamide results in increased expression of CFP mRNA |
CTD |
PMID:28284560 |
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NCBI chr X:1,162,014...1,167,576
Ensembl chr X:1,161,979...1,167,573
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
Niclosamide results in decreased phosphorylation of and affects the localization of CHUK protein |
CTD |
PMID:26116531 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
ISO |
Niclosamide results in decreased expression of COL1A1 mRNA |
CTD |
PMID:28824321 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Colec10 |
collectin subfamily member 10 |
increases expression |
ISO |
Niclosamide results in increased expression of COLEC10 mRNA |
CTD |
PMID:28284560 |
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NCBI chr 7:85,744,895...85,806,368
Ensembl chr 7:85,744,895...85,805,675
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G |
Crebbp |
CREB binding protein |
increases expression |
ISO |
Niclosamide results in increased expression of CREBBP mRNA |
CTD |
PMID:22576131 |
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NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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G |
Csf1 |
colony stimulating factor 1 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein] |
CTD |
PMID:28824321 |
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NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
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G |
Csgalnact1 |
chondroitin sulfate N-acetylgalactosaminyltransferase 1 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA] |
CTD |
PMID:27542212 |
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NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319
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G |
Csnk1e |
casein kinase 1, epsilon |
increases expression |
ISO |
Niclosamide results in increased expression of CSNK1E mRNA |
CTD |
PMID:22576131 |
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NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794
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G |
Csrnp1 |
cysteine and serine rich nuclear protein 1 |
increases expression |
ISO |
Niclosamide results in increased expression of CSRNP1 mRNA |
CTD |
PMID:28284560 |
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NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
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G |
Ctbp1 |
C-terminal binding protein 1 |
increases expression |
ISO |
Niclosamide results in increased expression of CTBP1 mRNA |
CTD |
PMID:22576131 |
|
NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821
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G |
Ctnnb1 |
catenin beta 1 |
increases expression decreases expression increases ubiquitination decreases activity multiple interactions |
ISO EXP |
Niclosamide results in increased expression of CTNNB1 mRNA Niclosamide results in decreased expression of CTNNB1 mRNA Niclosamide results in increased ubiquitination of CTNNB1 protein Niclosamide results in decreased activity of CTNNB1 protein Niclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]] Niclosamide analog results in decreased expression of CTNNB1 protein; Niclosamide results in decreased expression of CTNNB1 protein Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of CTNNB1 protein]; Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; Niclosamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of CTNNB1 protein] |
CTD |
PMID:19772353 PMID:21531761 PMID:22576131 PMID:24534281 PMID:24552774 PMID:24736023 PMID:25174399 PMID:26964897 PMID:27226553 PMID:27492973 PMID:28284560 PMID:30143678 PMID:32961231 More...
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctnnbip1 |
catenin, beta-interacting protein 1 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein] |
CTD |
PMID:24534281 |
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NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939
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G |
Ctsc |
cathepsin C |
decreases expression |
ISO |
Niclosamide results in decreased expression of CTSC protein |
CTD |
PMID:29480568 |
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NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
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G |
Ctsd |
cathepsin D |
decreases expression |
ISO |
Niclosamide results in decreased expression of CTSD protein |
CTD |
PMID:29480568 |
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NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Ctsk |
cathepsin K |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] |
CTD |
PMID:26792726 |
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NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
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G |
Cxcr5 |
C-X-C motif chemokine receptor 5 |
multiple interactions |
ISO |
Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA] |
CTD |
PMID:33632240 |
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NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893
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G |
Cycs |
cytochrome c, somatic |
increases expression |
ISO |
Niclosamide results in increased expression of CYCS protein |
CTD |
PMID:26703449 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases activity |
ISO |
Niclosamide results in increased activity of CYP1A1 protein |
CTD |
PMID:12451431 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity increases expression |
ISO |
Niclosamide results in decreased activity of CYP1A2 protein Niclosamide results in increased expression of CYP1A2 mRNA |
CTD |
PMID:11124226 PMID:28284560 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases activity |
ISO |
Niclosamide results in decreased activity of CYP2D6 protein |
CTD |
PMID:11124226 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp39a1 |
cytochrome P450, family 39, subfamily a, polypeptide 1 |
increases expression |
ISO |
Niclosamide results in increased expression of CYP39A1 mRNA |
CTD |
PMID:28284560 |
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NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity |
ISO |
Niclosamide results in decreased activity of CYP3A4 protein |
CTD |
PMID:11124226 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions |
ISO |
Niclosamide results in increased expression of DDIT3 mRNA; Niclosamide results in increased expression of DDIT3 protein ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA] |
CTD |
PMID:26917416 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Decr1 |
2,4-dienoyl-CoA reductase 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of DECR1 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
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G |
Dmac2l |
distal membrane arm assembly component 2 like |
decreases expression |
ISO |
Niclosamide results in decreased expression of DMAC2L mRNA |
CTD |
PMID:22576131 |
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NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933
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G |
Dscc1 |
DNA replication and sister chromatid cohesion 1 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA] |
CTD |
PMID:27542212 |
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NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212
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G |
Dvl1 |
dishevelled segment polarity protein 1 |
increases expression |
ISO |
Niclosamide results in increased expression of DVL1 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
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G |
Dvl2 |
dishevelled segment polarity protein 2 |
decreases expression multiple interactions |
ISO EXP |
Niclosamide results in decreased expression of DVL2 protein Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]] |
CTD |
PMID:19772353 PMID:21531761 PMID:30143678 PMID:32961231 |
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NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820
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G |
Dvl3 |
dishevelled segment polarity protein 3 |
increases expression |
ISO |
Niclosamide results in increased expression of DVL3 mRNA |
CTD |
PMID:22576131 |
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NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462
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G |
E2f1 |
E2F transcription factor 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of E2F1 mRNA |
CTD |
PMID:29843133 |
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NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
E2f8 |
E2F transcription factor 8 |
decreases expression |
ISO |
Niclosamide results in decreased expression of E2F8 mRNA |
CTD |
PMID:28284560 |
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NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
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G |
Ebf1 |
EBF transcription factor 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of EBF1 mRNA |
CTD |
PMID:27226553 |
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NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665
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G |
Echdc1 |
ethylmalonyl-CoA decarboxylase 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of ECHDC1 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 1:28,476,354...28,507,173
Ensembl chr 1:28,476,200...28,507,319
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G |
Echs1 |
enoyl-CoA hydratase, short chain 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of ECHS1 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
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G |
Egf |
epidermal growth factor |
decreases expression multiple interactions |
ISO |
Niclosamide results in decreased expression of EGF mRNA; Niclosamide results in decreased expression of EGF protein Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:30779072 |
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NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
decreases expression decreases phosphorylation |
ISO |
Niclosamide analog results in decreased expression of EGFR protein; Niclosamide results in decreased expression of EGFR mRNA; Niclosamide results in decreased expression of EGFR protein Niclosamide results in decreased phosphorylation of EGFR protein |
CTD |
PMID:28284560 PMID:28426875 PMID:30779072 |
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NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
increases expression |
ISO |
Niclosamide results in increased expression of EGR1 mRNA |
CTD |
PMID:28284560 |
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NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
increases expression multiple interactions |
ISO |
Niclosamide results in increased expression of EIF2AK3 mRNA ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]; Niclosamide results in increased expression of and results in increased phosphorylation of EIF2AK3 protein |
CTD |
PMID:26917416 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation |
ISO |
Niclosamide results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:26917416 |
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NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Eif4e |
eukaryotic translation initiation factor 4E |
multiple interactions |
ISO |
Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] |
CTD |
PMID:19771169 |
|
NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
decreases expression multiple interactions decreases phosphorylation |
ISO |
Niclosamide analog results in decreased expression of EIF4EBP1 protein modified form; Niclosamide results in decreased expression of EIF4EBP1 protein modified form Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] Niclosamide results in decreased phosphorylation of EIF4EBP1 protein |
CTD |
PMID:19771169 PMID:28284560 PMID:30258081 |
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NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Endod1 |
endonuclease domain containing 1 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA] |
CTD |
PMID:27542212 |
|
NCBI chr 8:11,209,123...11,238,680
Ensembl chr 8:11,211,110...11,238,892
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G |
Eno2 |
enolase 2 |
increases expression |
ISO |
Niclosamide results in increased expression of ENO2 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
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G |
Eno3 |
enolase 3 |
decreases expression |
ISO |
Niclosamide results in decreased expression of ENO3 mRNA |
CTD |
PMID:22576131 |
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NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
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G |
Ep300 |
E1A binding protein p300 |
increases expression |
ISO |
Niclosamide results in increased expression of EP300 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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G |
Eps8l3 |
EPS8 like 3 |
increases expression |
ISO |
Niclosamide results in increased expression of EPS8L3 mRNA |
CTD |
PMID:28284560 |
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Ensembl chr 2:195,514,692...195,528,085
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G |
Fam83d |
family with sequence similarity 83, member D |
decreases expression |
ISO |
Niclosamide results in decreased expression of FAM83D mRNA |
CTD |
PMID:28284560 |
|
NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192
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G |
Fas |
Fas cell surface death receptor |
multiple interactions |
ISO EXP |
Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of TCF7 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FAS mRNA] |
CTD |
PMID:28318631 PMID:33632240 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fgf1 |
fibroblast growth factor 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of FGF1 mRNA; Niclosamide results in decreased expression of FGF1 protein |
CTD |
PMID:25174399 |
|
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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G |
Fkbp5 |
FKBP prolyl isomerase 5 |
multiple interactions decreases expression |
ISO |
[Niclosamide co-treated with bicalutamide] results in decreased expression of FKBP5 mRNA Niclosamide results in decreased expression of FKBP5 mRNA |
CTD |
PMID:28500234 |
|
NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FN1 protein] HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA] |
CTD |
PMID:28318631 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA] Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein] |
CTD |
PMID:26792726 PMID:28824321 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Niclosamide results in increased expression of FOSB mRNA |
CTD |
PMID:28284560 |
|
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
ISO |
Niclosamide results in increased expression of FOSL1 mRNA |
CTD |
PMID:22576131 |
|
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Foxm1 |
forkhead box M1 |
multiple interactions decreases expression |
ISO |
Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of FOXM1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of FOXM1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of FOXM1 protein] |
CTD |
PMID:27492973 |
|
NCBI chr 4:161,639,561...161,652,012
Ensembl chr 4:161,638,816...161,650,684
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G |
Fscn1 |
fascin actin-bundling protein 1 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of FSCN1 mRNA] |
CTD |
PMID:29733962 |
|
NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211
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G |
Fzd1 |
frizzled class receptor 1 |
affects localization |
ISO |
Niclosamide affects the localization of FZD1 protein |
CTD |
PMID:19772353 |
|
NCBI chr 4:29,310,303...29,314,701
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G |
Fzd2 |
frizzled class receptor 2 |
decreases expression |
ISO |
Niclosamide results in decreased expression of FZD2 mRNA |
CTD |
PMID:22576131 |
|
NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
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G |
Fzd5 |
frizzled class receptor 5 |
increases expression |
ISO |
Niclosamide results in increased expression of FZD5 mRNA |
CTD |
PMID:22576131 |
|
NCBI chr 9:66,117,370...66,119,127
Ensembl chr 9:66,113,112...66,121,457
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G |
Fzd9 |
frizzled class receptor 9 |
decreases expression |
ISO |
Niclosamide results in decreased expression of FZD9 mRNA |
CTD |
PMID:22576131 |
|
NCBI chr12:21,427,084...21,429,398
Ensembl chr12:21,427,084...21,429,398
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G |
Gcg |
glucagon |
multiple interactions |
EXP |
Niclosamide inhibits the reaction [GCG protein results in increased abundance of Cyclic AMP]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein] |
CTD |
PMID:26964897 |
|
NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
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G |
Got2 |
glutamic-oxaloacetic transaminase 2 |
increases expression |
ISO |
Niclosamide results in increased expression of GOT2 mRNA |
CTD |
PMID:22576131 |
|
NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases expression decreases phosphorylation |
ISO |
Niclosamide results in decreased expression of GSK3B mRNA Niclosamide results in decreased phosphorylation of GSK3B protein |
CTD |
PMID:22576131 PMID:30143678 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gtse1 |
G-2 and S-phase expressed 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of GTSE1 mRNA |
CTD |
PMID:28284560 |
|
NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806
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G |
Hadh |
hydroxyacyl-CoA dehydrogenase |
decreases expression |
ISO |
Niclosamide results in decreased expression of HADH mRNA |
CTD |
PMID:22576131 |
|
NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
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G |
Hamp |
hepcidin antimicrobial peptide |
decreases expression increases expression |
ISO |
Niclosamide results in decreased expression of HAMP mRNA Niclosamide results in increased expression of HAMP mRNA |
CTD |
PMID:25633564 PMID:28284560 |
|
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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G |
Hbp1 |
HMG-box transcription factor 1 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA] |
CTD |
PMID:27542212 |
|
NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787
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G |
Hes1 |
hes family bHLH transcription factor 1 |
decreases expression multiple interactions |
ISO EXP |
Niclosamide results in decreased expression of HES1 protein Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HES1 mRNA] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HES1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]] |
CTD |
PMID:19160421 PMID:28318631 PMID:32961231 |
|
NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
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G |
Hey1 |
hes-related family bHLH transcription factor with YRPW motif 1 |
multiple interactions |
ISO EXP |
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY1 mRNA] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY1 mRNA] Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA] |
CTD |
PMID:27542212 PMID:28318631 |
|
NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312
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G |
Hey2 |
hes-related family bHLH transcription factor with YRPW motif 2 |
multiple interactions increases expression |
EXP ISO |
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY2 mRNA] Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY2 mRNA] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA] |
CTD |
PMID:19160421 PMID:28318631 |
|
NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
decreases expression multiple interactions |
ISO |
Niclosamide results in decreased expression of HIF1A mRNA; Niclosamide results in decreased expression of HIF1A protein Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA] |
CTD |
PMID:30779072 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hipk2 |
homeodomain interacting protein kinase 2 |
multiple interactions |
ISO EXP |
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 protein] HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein] |
CTD |
PMID:28318631 |
|
NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223
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G |
Hmmr |
hyaluronan-mediated motility receptor |
decreases expression |
ISO |
Niclosamide results in decreased expression of HMMR mRNA |
CTD |
PMID:28284560 |
|
NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
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G |
Hoxa1 |
homeobox A1 |
increases expression |
ISO |
Niclosamide results in increased expression of HOXA1 |
CTD |
PMID:26820057 |
|
NCBI chr 4:81,255,814...81,258,504
Ensembl chr 4:81,255,883...81,258,504
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO EXP |
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ICAM1 mRNA] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of ICAM1 mRNA] |
CTD |
PMID:28318631 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Igf1r |
insulin-like growth factor 1 receptor |
affects response to substance |
ISO |
IGF1R protein affects the susceptibility to Niclosamide |
CTD |
PMID:27497986 |
|
NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
affects localization |
ISO |
Niclosamide affects the localization of IKBKB protein |
CTD |
PMID:26116531 |
|
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Ikbkg |
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma |
affects localization |
ISO |
Niclosamide affects the localization of IKBKG protein |
CTD |
PMID:26116531 |
|
NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
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G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA] |
CTD |
PMID:26297436 |
|
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA] |
CTD |
PMID:33524445 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il21 |
interleukin 21 |
multiple interactions |
ISO |
Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL21 protein] |
CTD |
PMID:33632240 |
|
NCBI chr 2:120,119,598...120,126,941
Ensembl chr 2:120,119,444...120,126,996
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL6 protein] Niclosamide inhibits the reaction [IL6 protein results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of APPA mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of MYC protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of SOCS1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of TGFB1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein] |
CTD |
PMID:24561310 PMID:25970160 PMID:26297436 PMID:28318631 PMID:33632240 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itgav |
integrin subunit alpha V |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGAV mRNA] |
CTD |
PMID:26792726 |
|
NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
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G |
Itgb3 |
integrin subunit beta 3 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA] Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA] |
CTD |
PMID:26792726 PMID:28824321 |
|
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
affects localization multiple interactions increases phosphorylation increases expression |
EXP ISO |
Niclosamide affects the localization of JUN protein Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]]; Acetylcysteine inhibits the reaction [Niclosamide results in increased phosphorylation of JUN protein]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein] Niclosamide results in increased expression of JUN mRNA |
CTD |
PMID:24750999 PMID:27338550 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kif11 |
kinesin family member 11 |
decreases expression |
ISO |
Niclosamide results in decreased expression of KIF11 mRNA |
CTD |
PMID:28284560 |
|
NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
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G |
Kif20a |
kinesin family member 20A |
decreases expression |
ISO |
Niclosamide results in decreased expression of KIF20A mRNA |
CTD |
PMID:28284560 |
|
NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
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G |
Kifc1 |
kinesin family member C1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of KIFC1 mRNA |
CTD |
PMID:28284560 |
|
NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105
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G |
Lcat |
lecithin cholesterol acyltransferase |
increases expression |
ISO |
Niclosamide results in increased expression of LCAT mRNA |
CTD |
PMID:28284560 |
|
NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
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G |
Ldha |
lactate dehydrogenase A |
increases expression |
ISO |
Niclosamide results in increased expression of LDHA mRNA |
CTD |
PMID:22576131 |
|
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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G |
Lrp5 |
LDL receptor related protein 5 |
multiple interactions |
EXP |
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]] |
CTD |
PMID:32961231 |
|
NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581
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G |
Lrp6 |
LDL receptor related protein 6 |
decreases expression multiple interactions |
ISO EXP |
Niclosamide analog results in decreased expression of LRP6 protein; Niclosamide results in decreased expression of LRP6 protein Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]] Niclosamide results in decreased expression of and results in decreased phosphorylation of LRP6 protein |
CTD |
PMID:24552774 PMID:24736023 PMID:28284560 PMID:32961231 |
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NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
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G |
Mad2l1 |
mitotic arrest deficient 2 like 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of MAD2L1 mRNA |
CTD |
PMID:28284560 |
|
NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases expression |
ISO |
Niclosamide results in increased expression of MAP1LC3B protein modified form |
CTD |
PMID:30258081 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
Niclosamide results in decreased phosphorylation of MAPK1 protein Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation |
ISO |
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] Niclosamide results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:28824321 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:28824321 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
ISO |
Niclosamide results in decreased expression of MCL1 protein |
CTD |
PMID:20215516 PMID:26116531 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mcm2 |
minichromosome maintenance complex component 2 |
decreases expression |
ISO |
Niclosamide results in decreased expression of MCM2 mRNA; Niclosamide results in decreased expression of MCM2 protein |
CTD |
PMID:28284560 PMID:29031202 |
|
NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
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G |
Mcm7 |
minichromosome maintenance complex component 7 |
decreases expression |
ISO |
Niclosamide results in decreased expression of MCM7 protein |
CTD |
PMID:29031202 |
|
NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063
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G |
Met |
MET proto-oncogene, receptor tyrosine kinase |
decreases expression |
EXP |
Niclosamide results in decreased expression of MET mRNA |
CTD |
PMID:27338550 |
|
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
Niclosamide results in decreased expression of MKI67 mRNA |
CTD |
PMID:28284560 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mme |
membrane metallo-endopeptidase |
decreases expression |
ISO |
Niclosamide results in decreased expression of MME mRNA; Niclosamide results in decreased expression of MME protein |
CTD |
PMID:29480568 |
|
NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression |
ISO |
Niclosamide results in decreased expression of MMP2 mRNA; Niclosamide results in decreased expression of MMP2 protein |
CTD |
PMID:29251334 PMID:30143678 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp7 |
matrix metallopeptidase 7 |
multiple interactions decreases expression |
EXP ISO |
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of MMP7 mRNA] Niclosamide inhibits the reaction [Doxorubicin results in increased expression of MMP7 mRNA] Niclosamide results in decreased expression of MMP7 mRNA |
CTD |
PMID:27338550 PMID:28318631 |
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NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression multiple interactions |
ISO |
Niclosamide results in decreased expression of MMP9 mRNA; Niclosamide results in decreased expression of MMP9 protein Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA] |
CTD |
PMID:28824321 PMID:29480568 PMID:30143678 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mt2A |
metallothionein 2A |
increases expression |
ISO |
Niclosamide results in increased expression of MT2A mRNA |
CTD |
PMID:28284560 |
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NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation multiple interactions increases expression |
ISO |
Niclosamide analog results in decreased phosphorylation of MTOR protein; Niclosamide results in decreased phosphorylation of MTOR protein Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of MTOR protein]; Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein] Niclosamide results in increased expression of MTOR mRNA |
CTD |
PMID:19771169 PMID:26643609 PMID:26703449 PMID:28284560 PMID:29843133 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions decreases expression |
EXP ISO |
Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA] Niclosamide results in decreased expression of MYC mRNA; Niclosamide results in decreased expression of MYC protein [Niclosamide binds to Polyethyleneimine] which results in increased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC protein; enzalutamide promotes the reaction [Niclosamide results in decreased expression of MYC protein]; Niclosamide inhibits the reaction [bicalutamide results in increased expression of MYC protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of MYC protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of MYC mRNA] |
CTD |
PMID:19160421 PMID:20215516 PMID:22576131 PMID:25970160 PMID:25988281 PMID:26964897 PMID:28500234 PMID:29843133 More...
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Ndufa10 |
NADH:ubiquinone oxidoreductase subunit A10 |
decreases expression |
ISO |
Niclosamide results in decreased expression of NDUFA10 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560
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G |
Ndufa4l2 |
NDUFA4, mitochondrial complex associated like 2 |
increases expression |
ISO |
Niclosamide results in increased expression of NDUFA4L2 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 7:63,351,021...63,359,010
Ensembl chr 7:63,356,883...63,359,010
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G |
Ndufa7 |
NADH:ubiquinone oxidoreductase subunit A7 |
decreases expression |
ISO |
Niclosamide results in decreased expression of NDUFA7 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 7:14,609,283...14,622,064
Ensembl chr 7:14,609,146...14,631,976
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G |
Ndufa8 |
NADH:ubiquinone oxidoreductase subunit A8 |
decreases expression |
ISO |
Niclosamide results in decreased expression of NDUFA8 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 3:19,386,063...19,402,093
Ensembl chr 3:19,386,065...19,402,071
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G |
Ndufb10 |
NADH:ubiquinone oxidoreductase subunit B10 |
decreases expression |
ISO |
Niclosamide results in decreased expression of NDUFB10 mRNA |
CTD |
PMID:22576131 |
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NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442
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Ndufb6 |
NADH:ubiquinone oxidoreductase subunit B6 |
decreases expression |
ISO |
Niclosamide results in decreased expression of NDUFB6 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181
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G |
Ndufc1 |
NADH:ubiquinone oxidoreductase subunit C1 |
increases expression |
ISO |
Niclosamide results in increased expression of NDUFC1 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 2:135,447,067...135,450,950
Ensembl chr 2:135,447,119...135,450,874
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G |
Ndufs2 |
NADH:ubiquinone oxidoreductase core subunit S2 |
decreases expression |
ISO |
Niclosamide results in decreased expression of NDUFS2 mRNA |
CTD |
PMID:22576131 |
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NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420
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G |
Ndufs3 |
NADH:ubiquinone oxidoreductase core subunit S3 |
decreases expression |
ISO |
Niclosamide results in decreased expression of NDUFS3 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824
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G |
Ndufs7 |
NADH:ubiquinone oxidoreductase core subunit S7 |
decreases expression |
ISO |
Niclosamide results in decreased expression of NDUFS7 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195
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G |
Ndufs8 |
NADH:ubiquinone oxidoreductase core subunit S8 |
decreases expression |
ISO |
Niclosamide results in decreased expression of NDUFS8 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511
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G |
Ndufv3 |
NADH:ubiquinone oxidoreductase subunit V3 |
increases expression |
ISO |
Niclosamide results in increased expression of NDUFV3 mRNA |
CTD |
PMID:22576131 |
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NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074
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G |
Nfatc1 |
nuclear factor of activated T-cells 1 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA] |
CTD |
PMID:26792726 PMID:28824321 |
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NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
affects localization |
ISO |
Niclosamide affects the localization of NFKB1 protein |
CTD |
PMID:26116531 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
decreases phosphorylation multiple interactions |
ISO |
Niclosamide results in decreased phosphorylation of NFKBIA protein Niclosamide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Niclosamide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Niclosamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:20215516 PMID:26116531 PMID:27492973 PMID:28824321 PMID:33524445 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nkd1 |
NKD inhibitor of WNT signaling pathway 1 |
multiple interactions increases expression |
ISO |
Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of NKD1 mRNA] Niclosamide results in increased expression of NKD1 mRNA |
CTD |
PMID:22576131 PMID:24534281 |
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NCBI chr19:18,476,344...18,549,380
Ensembl chr19:18,476,344...18,549,380
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G |
Nkx3-1 |
NK3 homeobox 1 |
multiple interactions decreases expression |
ISO |
[Niclosamide co-treated with bicalutamide] results in decreased expression of NKX3-1 mRNA Niclosamide results in decreased expression of NKX3-1 mRNA |
CTD |
PMID:28500234 |
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NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein] |
CTD |
PMID:33524445 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Notch1 |
notch receptor 1 |
decreases activity multiple interactions |
ISO EXP |
Niclosamide results in decreased activity of NOTCH1 protein Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]] |
CTD |
PMID:19160421 PMID:32961231 |
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NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions |
ISO |
Niclosamide binds to and results in increased activity of NR1I3 protein alternative form |
CTD |
PMID:31312845 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Ocstamp |
osteoclast stimulatory transmembrane protein |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA] |
CTD |
PMID:28824321 |
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NCBI chr 3:154,131,113...154,141,611
Ensembl chr 3:154,132,328...154,136,991
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G |
Orc1 |
origin recognition complex, subunit 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of ORC1 mRNA |
CTD |
PMID:28284560 |
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NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375
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G |
Oscar |
osteoclast associated Ig-like receptor |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA] Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA] |
CTD |
PMID:26792726 PMID:28824321 |
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NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions decreases expression increases expression increases cleavage |
ISO |
[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased cleavage of PARP1 protein Niclosamide results in decreased expression of PARP1 protein Niclosamide results in increased expression of PARP1 protein modified form Niclosamide results in increased cleavage of PARP1 protein 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Niclosamide results in increased cleavage of PARP1 protein]; bicalutamide promotes the reaction [Niclosamide results in increased expression of PARP1 protein modified form]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein] |
CTD |
PMID:24750999 PMID:25174399 PMID:26917416 PMID:28500234 PMID:30258081 PMID:30329025 More...
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pc |
pyruvate carboxylase |
increases expression |
ISO |
Niclosamide results in increased expression of PC mRNA |
CTD |
PMID:22576131 |
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NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
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G |
Pfkm |
phosphofructokinase, muscle |
decreases expression |
ISO |
Niclosamide results in decreased expression of PFKM mRNA |
CTD |
PMID:22576131 |
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NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
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G |
Phlda1 |
pleckstrin homology-like domain, family A, member 1 |
increases expression |
ISO |
Niclosamide results in increased expression of PHLDA1 mRNA |
CTD |
PMID:28284560 |
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NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
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G |
Pik3ca |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
increases expression multiple interactions |
ISO |
Niclosamide results in increased expression of PIK3CA mRNA Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CXCL8 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA] |
CTD |
PMID:27542212 PMID:29843133 |
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NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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G |
Pkm |
pyruvate kinase M1/2 |
increases expression |
ISO |
Niclosamide results in increased expression of PKM mRNA |
CTD |
PMID:22576131 |
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NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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G |
Pou5f1 |
POU class 5 homeobox 1 |
decreases phosphorylation |
ISO |
Niclosamide results in decreased phosphorylation of POU5F1 protein |
CTD |
PMID:23333246 |
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NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
increases expression |
ISO |
Niclosamide results in increased expression of PPARD mRNA |
CTD |
PMID:22576131 |
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NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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G |
Ppp2cb |
protein phosphatase 2 catalytic subunit beta |
decreases expression |
ISO |
Niclosamide results in decreased expression of PPP2CB mRNA |
CTD |
PMID:22576131 |
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NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
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G |
Ppp2r1a |
protein phosphatase 2 scaffold subunit A alpha |
increases expression |
ISO |
Niclosamide results in increased expression of PPP2R1A mRNA |
CTD |
PMID:22576131 |
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NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
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G |
Ppp2r1b |
protein phosphatase 2 scaffold subunit A beta |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA] |
CTD |
PMID:27542212 |
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NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485
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G |
Ppp2r2b |
protein phosphatase 2, regulatory subunit B, beta |
decreases expression |
ISO |
Niclosamide results in decreased expression of PPP2R2B mRNA |
CTD |
PMID:22576131 |
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NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025
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G |
Ppp2r2c |
protein phosphatase 2, regulatory subunit B, gamma |
decreases expression |
ISO |
Niclosamide results in decreased expression of PPP2R2C mRNA |
CTD |
PMID:22576131 |
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NCBI chr14:73,846,547...73,931,178
Ensembl chr14:73,846,547...73,931,864
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G |
Prdm1 |
PR/SET domain 1 |
multiple interactions |
ISO |
Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA] |
CTD |
PMID:33632240 |
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NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
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G |
Prkcq |
protein kinase C, theta |
increases expression |
ISO |
Niclosamide results in increased expression of PRKCQ mRNA |
CTD |
PMID:22576131 |
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NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704
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G |
Pten |
phosphatase and tensin homolog |
increases expression |
ISO |
Niclosamide results in increased expression of PTEN mRNA |
CTD |
PMID:29843133 |
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NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
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G |
Rad54l |
RAD54 like |
increases expression |
ISO |
Niclosamide results in increased expression of RAD54L mRNA |
CTD |
PMID:28284560 |
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NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070
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G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
decreases phosphorylation decreases expression |
ISO |
Niclosamide analog results in decreased phosphorylation of RAF1 protein Niclosamide analog results in decreased expression of RAF1 protein; Niclosamide results in decreased expression of RAF1 protein |
CTD |
PMID:28284560 |
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NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases expression |
ISO EXP |
Niclosamide affects the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of and results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of RELA protein modified form] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of RELA protein modified form] Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of RELA protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of RELA protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of RELA protein]; Niclosamide results in decreased phosphorylation of and affects the localization of RELA protein |
CTD |
PMID:20215516 PMID:26116531 PMID:26643609 PMID:27492973 PMID:28318631 PMID:28824321 PMID:33524445 More...
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rhof |
ras homolog family member F, filopodia associated |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of RHOF mRNA] |
CTD |
PMID:29733962 |
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NCBI chr12:33,422,375...33,446,689
Ensembl chr12:33,431,280...33,446,703
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G |
Ripor3 |
RIPOR family member 3 |
increases expression |
ISO |
Niclosamide results in increased expression of FAM65C mRNA |
CTD |
PMID:28284560 |
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NCBI chr 3:156,687,253...156,760,524
Ensembl chr 3:156,687,517...156,715,061
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G |
Rock1 |
Rho-associated coiled-coil containing protein kinase 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of ROCK1 mRNA; Niclosamide results in decreased expression of ROCK1 protein |
CTD |
PMID:29251334 |
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NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
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G |
Rps6 |
ribosomal protein S6 |
affects phosphorylation |
ISO |
Niclosamide affects the phosphorylation of RPS6 protein |
CTD |
PMID:27542212 |
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NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases phosphorylation |
ISO |
Niclosamide results in decreased phosphorylation of RPS6KB1 protein |
CTD |
PMID:27542212 PMID:30258081 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Rrm2 |
ribonucleotide reductase regulatory subunit M2 |
decreases expression |
ISO |
Niclosamide results in decreased expression of RRM2 mRNA |
CTD |
PMID:28284560 |
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NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
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G |
Runx2 |
RUNX family transcription factor 2 |
decreases expression |
ISO |
Niclosamide results in decreased expression of RUNX2 mRNA |
CTD |
PMID:28824321 |
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NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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G |
S100a4 |
S100 calcium-binding protein A4 |
decreases expression multiple interactions |
ISO |
Niclosamide results in decreased expression of S100A4 mRNA; Niclosamide results in decreased expression of S100A4 protein Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of S100A4 protein] |
CTD |
PMID:21685359 PMID:29733962 |
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NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of SERPINE1 mRNA] |
CTD |
PMID:28318631 |
|
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Serpine2 |
serpin family E member 2 |
multiple interactions |
EXP |
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE2 mRNA] |
CTD |
PMID:28318631 |
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NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
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G |
Slc2a1 |
solute carrier family 2 member 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of SLC2A1 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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G |
Slc2a3 |
solute carrier family 2 member 3 |
decreases expression |
ISO |
Niclosamide results in decreased expression of SLC2A3 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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G |
Smad3 |
SMAD family member 3 |
multiple interactions |
ISO EXP |
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] Niclosamide inhibits the reaction [Doxorubicin results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:28318631 |
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NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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G |
Snai1 |
snail family transcriptional repressor 1 |
multiple interactions decreases expression |
ISO EXP |
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of SNAI1 mRNA] Niclosamide results in decreased expression of SNAI1 mRNA; Niclosamide results in decreased expression of SNAI1 protein Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of SNAI1 protein] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA] |
CTD |
PMID:26643609 PMID:28318631 PMID:30143678 |
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NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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G |
Snai2 |
snail family transcriptional repressor 2 |
multiple interactions decreases expression |
ISO |
WNT7A protein affects the reaction [Niclosamide results in increased expression of SNAI2 protein] Niclosamide results in decreased expression of SNAI2 protein |
CTD |
PMID:25174399 |
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NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of SRC protein] |
CTD |
PMID:26643609 |
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NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G |
Stat3 |
signal transducer and activator of transcription 3 |
decreases phosphorylation multiple interactions decreases expression |
ISO |
Niclosamide analog results in decreased phosphorylation of STAT3 protein; Niclosamide results in decreased phosphorylation of STAT3 protein Niclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein] [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; enzalutamide promotes the reaction [Niclosamide results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Niclosamide inhibits the reaction [STAT3 protein results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of STAT3 protein]; Niclosamide results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of STAT3 protein; Niclosamide results in decreased expression of and results in decreased phosphorylation of STAT3 protein Niclosamide analog results in decreased expression of STAT3 protein; Niclosamide results in decreased expression of STAT3 protein |
CTD |
PMID:23333246 PMID:23894143 PMID:24552774 PMID:25970160 PMID:26116531 PMID:26792726 PMID:28284560 PMID:29031202 PMID:29251334 PMID:30329025 PMID:30779072 PMID:33632240 More...
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tacc3 |
transforming, acidic coiled-coil containing protein 3 |
decreases expression |
ISO |
Niclosamide results in decreased expression of TACC3 mRNA |
CTD |
PMID:28284560 |
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NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219
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G |
Tcf7 |
transcription factor 7 |
multiple interactions |
ISO |
Niclosamide affects the reaction [FAS protein mutant form affects the expression of TCF7 protein] |
CTD |
PMID:33632240 |
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NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535
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G |
Tcim |
transcriptional and immune response regulator |
increases expression |
ISO |
Niclosamide results in increased expression of TCIM mRNA |
CTD |
PMID:28284560 |
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NCBI chr16:67,595,762...67,597,055
Ensembl chr16:67,593,410...67,597,581
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO EXP |
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL20 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FAS mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HES1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of ICAM1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of MMP7 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of RELA protein modified form]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:28318631 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
increases expression |
ISO |
Niclosamide results in increased expression of TIMP2 mRNA |
CTD |
PMID:30143678 |
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NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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G |
Tk1 |
thymidine kinase 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of TK1 mRNA |
CTD |
PMID:28284560 |
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NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases activity |
ISO |
Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF mRNA]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of FOXM1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of MYC mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] Niclosamide results in decreased activity of TNF protein |
CTD |
PMID:20215516 PMID:24561310 PMID:27492973 PMID:28318631 PMID:33524445 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfsf11 |
TNF superfamily member 11 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGAV mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of STAT3 protein] Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein] |
CTD |
PMID:26792726 PMID:28824321 |
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NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression decreases response to substance increases response to substance |
ISO |
[Niclosamide binds to Polyethyleneimine] which results in increased expression of TP53 mRNA; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of BBC3 mRNA]; TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP3 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA] [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of adrenic acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Arachidonic Acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Docosahexaenoic Acids; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Eicosapentaenoic Acid; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Lysophosphatidylcholines; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of lysophosphatidylethanolamine; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased cleavage of PARP1 protein; [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased expression of CASP3 protein modified form Niclosamide results in increased expression of TP53 mRNA; Niclosamide results in increased expression of TP53 protein TP53 protein results in decreased susceptibility to Niclosamide TP53 gene mutant form results in increased susceptibility to Niclosamide; TP53 protein mutant form results in increased susceptibility to Niclosamide Niclosamide results in increased expression of TRP53 protein |
CTD |
PMID:22576131 PMID:25988281 PMID:29031202 PMID:30258081 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tpi1 |
triosephosphate isomerase 1 |
increases expression |
ISO |
Niclosamide results in increased expression of TPI1 mRNA |
CTD |
PMID:22576131 |
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NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
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G |
Tpx2 |
TPX2, microtubule nucleation factor |
decreases expression |
ISO |
Niclosamide results in decreased expression of TPX2 mRNA |
CTD |
PMID:28284560 |
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NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468
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G |
Traf6 |
TNF receptor associated factor 6 |
multiple interactions |
ISO |
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein] |
CTD |
PMID:28824321 |
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NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
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G |
Trip13 |
thyroid hormone receptor interactor 13 |
decreases expression |
ISO |
Niclosamide results in decreased expression of TRIP13 mRNA |
CTD |
PMID:28284560 |
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NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074
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G |
Twist1 |
twist family bHLH transcription factor 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of TWIST1 protein |
CTD |
PMID:29480568 |
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NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
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G |
Ube2c |
ubiquitin-conjugating enzyme E2C |
multiple interactions decreases expression |
ISO |
[Niclosamide co-treated with bicalutamide] results in decreased expression of UBE2C mRNA Niclosamide results in decreased expression of UBE2C mRNA |
CTD |
PMID:28500234 |
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NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
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G |
Uhrf1 |
ubiquitin-like with PHD and ring finger domains 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of UHRF1 mRNA |
CTD |
PMID:28284560 |
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NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
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G |
Utp3 |
UTP3, small subunit processome component |
decreases expression |
ISO |
Niclosamide results in decreased expression of UTP3 mRNA |
CTD |
PMID:27226553 |
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NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
Niclosamide results in decreased expression of VEGFA mRNA; Niclosamide results in decreased expression of VEGFA protein |
CTD |
PMID:29251334 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Vim |
vimentin |
multiple interactions decreases expression |
ISO |
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of VIM protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA] Niclosamide results in decreased expression of VIM mRNA; Niclosamide results in decreased expression of VIM protein |
CTD |
PMID:26643609 PMID:28318631 PMID:30143678 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Vpreb1 |
V-set pre-B cell surrogate light chain 1 |
decreases expression |
ISO |
Niclosamide results in decreased expression of VPREB1 mRNA |
CTD |
PMID:27226553 |
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NCBI chr11:84,126,969...84,127,846
Ensembl chr11:84,126,969...84,127,846
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G |
Wnt2b |
Wnt family member 2B |
decreases expression |
ISO |
Niclosamide results in decreased expression of WNT2B mRNA |
CTD |
PMID:22576131 |
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NCBI chr 2:192,454,226...192,468,599
Ensembl chr 2:192,453,824...192,470,308
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G |
Wnt3 |
Wnt family member 3 |
decreases expression |
ISO |
Niclosamide results in decreased expression of WNT3 mRNA |
CTD |
PMID:22576131 |
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NCBI chr10:88,680,248...88,724,170
Ensembl chr10:88,680,248...88,724,099
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G |
Wnt3a |
Wnt family member 3A |
multiple interactions decreases expression |
ISO EXP |
Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein] Niclosamide inhibits the reaction [Thioacetamide results in increased expression of WNT3A mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of WNT3A mRNA]] Niclosamide results in decreased expression of WNT3A mRNA |
CTD |
PMID:19772353 PMID:22576131 PMID:27492973 PMID:32961231 |
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NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324
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G |
Wnt7a |
Wnt family member 7A |
increases response to substance multiple interactions decreases activity |
ISO |
WNT7A protein results in increased susceptibility to Niclosamide WNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of SNAI2 protein] Niclosamide results in decreased activity of WNT7A protein |
CTD |
PMID:25174399 |
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NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981
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G |
Xiap |
X-linked inhibitor of apoptosis |
decreases expression |
ISO |
Niclosamide results in decreased expression of XIAP protein |
CTD |
PMID:20215516 |
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NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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G |
Zfp36 |
zinc finger protein 36 |
increases expression |
ISO |
Niclosamide results in increased expression of ZFP36 mRNA |
CTD |
PMID:28284560 |
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NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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G |
Zic2 |
Zic family member 2 |
increases expression |
ISO |
Niclosamide results in increased expression of ZIC2 mRNA |
CTD |
PMID:28284560 |
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NCBI chr15:99,576,697...99,581,522
Ensembl chr15:99,576,697...99,581,522
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G |
Jak2 |
Janus kinase 2 |
multiple interactions |
ISO |
S3I-201 inhibits the reaction [Rapamycin increases phosphorylation of JAK2 protein in lung epithelium] |
RGD |
PMID:30755242 |
RGD:149735343 |
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
stattic inhibits the reaction [Arsenicals results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:23255093 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
stattic results in decreased expression of BCL2 protein |
CTD |
PMID:24627483 PMID:25611565 |
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NCBI chr13:22,689,783...22,853,920
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
stattic inhibits the reaction [glycine-extended gastrin 17 results in increased expression of BCL2L1 mRNA] |
CTD |
PMID:19153190 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions |
ISO |
stattic inhibits the reaction [glycine-extended gastrin 17 results in increased expression of BIRC5 mRNA] |
CTD |
PMID:19153190 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Ccn2 |
cellular communication network factor 2 |
multiple interactions |
ISO |
stattic inhibits the reaction [IL6 protein results in increased expression of CCN2 mRNA] stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCN2 mRNA] |
CTD |
PMID:25740948 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
EXP ISO |
stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 protein] stattic affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein] |
CTD |
PMID:30670587 PMID:33396024 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cd44 |
CD44 molecule (Indian blood group) |
multiple interactions |
ISO |
stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]] |
CTD |
PMID:33396024 |
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NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 mRNA]] |
CTD |
PMID:33396024 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cish |
cytokine inducible SH2-containing protein |
multiple interactions |
ISO |
stattic inhibits the reaction [IL6 protein results in increased expression of CISH mRNA] |
CTD |
PMID:26297436 |
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NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
stattic inhibits the reaction [IL6 protein results in increased expression of COL1A1 mRNA] stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A1 mRNA] |
CTD |
PMID:25740948 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Edn1 |
endothelin 1 |
multiple interactions |
EXP |
stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 protein]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 protein] |
CTD |
PMID:30670587 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
stattic inhibits the reaction [EGF protein results in increased expression of PSMB5 protein]; stattic inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:24627483 |
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NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
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G |
Ezh2 |
enhancer of zeste 2 polycomb repressive complex 2 subunit |
multiple interactions |
ISO |
stattic inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein] |
CTD |
PMID:23255093 |
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NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
stattic inhibits the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GPT protein] |
CTD |
PMID:28887131 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A protein] |
CTD |
PMID:29341321 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
stattic inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein] |
CTD |
PMID:29329563 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
stattic inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA] |
CTD |
PMID:26297436 |
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NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
stattic inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of IL1B mRNA] |
CTD |
PMID:22454431 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
[stattic co-treated with IL6 protein] results in increased expression of SOCS3 protein; stattic affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein]; stattic inhibits the reaction [IL6 protein results in increased activity of TGFB1 protein]; stattic inhibits the reaction [IL6 protein results in increased expression of APPA mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of CCN2 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of CISH mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of COL1A1 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A protein]; stattic inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein] stattic inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]; stattic inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of IL6 mRNA] |
CTD |
PMID:22454431 PMID:25740948 PMID:26297436 PMID:28739487 PMID:29341321 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Jak2 |
Janus kinase 2 |
multiple interactions |
ISO |
stattic inhibits the reaction [deoxynivalenol results in increased expression of JAK2 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of JAK2 mRNA] |
CTD |
PMID:22454431 |
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NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:24434654 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mir21 |
microRNA 21 |
affects expression multiple interactions |
ISO |
stattic affects the expression of MIR21 mRNA stattic affects the reaction [arsenic trichloride affects the expression of MIR21 mRNA] |
CTD |
PMID:24434654 |
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NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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G |
Mmp10 |
matrix metallopeptidase 10 |
decreases expression |
ISO |
stattic results in decreased expression of MMP10 mRNA |
CTD |
PMID:22285823 |
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NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] |
CTD |
PMID:25740948 |
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NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
stattic affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; stattic affects the reaction [CXCL8 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]] |
CTD |
PMID:33396024 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Psmb1 |
proteasome 20S subunit beta 1 |
decreases expression |
ISO |
stattic results in decreased expression of PSMB1 mRNA; stattic results in decreased expression of PSMB1 protein |
CTD |
PMID:24627483 |
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NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560
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G |
Psmb2 |
proteasome 20S subunit beta 2 |
decreases expression |
ISO |
stattic results in decreased expression of PSMB2 mRNA; stattic results in decreased expression of PSMB2 protein |
CTD |
PMID:24627483 |
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NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137
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G |
Psmb3 |
proteasome 20S subunit beta 3 |
decreases expression |
ISO |
stattic results in decreased expression of PSMB3 mRNA; stattic results in decreased expression of PSMB3 protein |
CTD |
PMID:24627483 |
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NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521
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G |
Psmb4 |
proteasome 20S subunit beta 4 |
decreases expression |
ISO |
stattic results in decreased expression of PSMB4 mRNA; stattic results in decreased expression of PSMB4 protein |
CTD |
PMID:24627483 |
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NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746
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G |
Psmb5 |
proteasome 20S subunit beta 5 |
decreases expression multiple interactions |
ISO |
stattic results in decreased expression of PSMB5 mRNA; stattic results in decreased expression of PSMB5 protein stattic inhibits the reaction [EGF protein results in increased expression of PSMB5 protein] |
CTD |
PMID:24627483 |
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NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440
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G |
Psmb6 |
proteasome 20S subunit beta 6 |
decreases expression |
ISO |
stattic results in decreased expression of PSMB6 mRNA; stattic results in decreased expression of PSMB6 protein |
CTD |
PMID:24627483 |
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NCBI chr10:55,239,274...55,241,581
Ensembl chr10:55,239,241...55,241,586
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G |
Psmb7 |
proteasome 20S subunit beta 7 |
decreases expression |
ISO |
stattic results in decreased expression of PSMB7 mRNA; stattic results in decreased expression of PSMB7 protein |
CTD |
PMID:24627483 |
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NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937
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G |
Riox2 |
ribosomal oxygenase 2 |
multiple interactions |
ISO |
stattic inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of RIOX2 protein] |
CTD |
PMID:24434654 |
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NCBI chr11:40,861,365...40,884,782
Ensembl chr11:40,860,774...40,884,574
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G |
Skp2 |
S-phase kinase associated protein 2 |
multiple interactions |
EXP |
stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 protein] |
CTD |
PMID:30670587 |
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NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
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G |
Snai1 |
snail family transcriptional repressor 1 |
multiple interactions |
ISO |
stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 mRNA]] |
CTD |
PMID:33396024 |
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NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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G |
Snai2 |
snail family transcriptional repressor 2 |
multiple interactions |
ISO |
stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 mRNA]] |
CTD |
PMID:33396024 |
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NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
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G |
Socs3 |
suppressor of cytokine signaling 3 |
multiple interactions |
ISO |
[stattic co-treated with IL6 protein] results in increased expression of SOCS3 protein |
CTD |
PMID:25740948 |
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NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
stattic inhibits the reaction [deoxynivalenol results in increased expression of STAT1 mRNA]; stattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT1 protein]; stattic inhibits the reaction [T-2 Toxin results in increased expression of STAT1 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT1 protein] |
CTD |
PMID:22454431 |
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NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions decreases phosphorylation |
ISO EXP |
stattic affects the reaction [Arsenicals affects the phosphorylation of STAT3 protein]; stattic affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein]; stattic inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein] Stattic inhibits the reaction [Il-6 increases phosphorylation of STAT3 protein in the stomach) stattic inhibits the reaction [zoniporide results in increased phosphorylation of STAT3 protein] stattic inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [deoxynivalenol results in increased expression of STAT3 mRNA]; stattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [T-2 Toxin results in increased expression of STAT3 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein] stattic results in decreased phosphorylation of STAT3 protein |
CTD RGD |
PMID:20942815 PMID:22454431 PMID:23255093 PMID:24627483 PMID:25740948 PMID:28739487 PMID:29341321 PMID:29408335 More...
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RGD:127284846 |
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
stattic inhibits the reaction [IL6 protein results in increased activity of TGFB1 protein]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1 mRNA] stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TGFB1 mRNA] |
CTD |
PMID:25740948 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
stattic inhibits the reaction [deoxynivalenol results in increased expression of TNF mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of TNF mRNA] |
CTD |
PMID:22454431 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Twist1 |
twist family bHLH transcription factor 1 |
multiple interactions |
ISO |
stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 mRNA]] |
CTD |
PMID:33396024 |
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NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
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G |
Vim |
vimentin |
multiple interactions |
ISO |
stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM mRNA]] |
CTD |
PMID:33396024 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
tyrphostin B42 alone or co-treated with Nimesulide decreases expression of BIRC5 protein in esophagus squamous epithelium |
RGD |
PMID:25724470 |
RGD:127285656 |
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases cleavage of CASP3 protein in stomach] |
RGD |
PMID:32106377 |
RGD:127284886 |
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid decreases cleavage of CASP9 protein in stomach] |
RGD |
PMID:32106377 |
RGD:127284886 |
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Jak2 |
Janus kinase 2 |
decreases expression multiple interactions |
EXP ISO |
Turphostin B42 decreased expression of Jak2 mRNA in myofibroblasts tyrphostin B42 inhibits the reaction [cisplatin increases expression of Jak2 mRNA in kidney] tyrphostin B42 inhibits the reaction [selumetinib increases phosphorylation of JAK2 protein in colonic epithelium] tyrphostin B42 decreases expression and phosphorylation of JAK2 protein in colonic epithelium tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases phosphorylation of JAK2 protein in stomach] |
RGD |
PMID:26385087 PMID:31250048 PMID:30706361 PMID:22050790 PMID:32106377 |
RGD:18337263, RGD:149735351, RGD:127285668, RGD:127285665, RGD:127284886 |
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Mt-co2 |
mitochondrially encoded cytochrome c oxidase II |
decreases expression |
ISO |
Tyrphostin B42 alone or co-treated with Nimesulide decreases expression of MT-CO2 protein in esophagus squamous epithelium |
RGD |
PMID:25724470 |
RGD:127285656 |
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases phosphorylation of STAT3 protein in stomach] |
RGD |
PMID:32106377 |
RGD:127284886 |
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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