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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:STAT3 inhibitor
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Accession:CHEBI:87183 term browser browse the term
Definition:An inhibitor of signal transducer and activator of transcription 3 (STAT3)
Synonyms:related_synonym: STAT3 inhibitors;   signal transducer and activator of transcription 3 inhibitor;   signal transducer and activator of transcription 3 inhibitors
 xref: Wikipedia:STAT3

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S3I-201 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak2 Janus kinase 2 multiple interactions ISO S3I-201 inhibits the reaction [Rapamycin increases phosphorylation of JAK2 protein in lung epithelium] RGD PMID:30755242 RGD:149735343 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
stattic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO stattic inhibits the reaction [Arsenicals results in increased phosphorylation of AKT1 protein] CTD PMID:23255093 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO stattic results in decreased expression of BCL2 protein CTD PMID:24627483 PMID:25611565 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO stattic inhibits the reaction [glycine-extended gastrin 17 results in increased expression of BCL2L1 mRNA] CTD PMID:19153190 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO stattic inhibits the reaction [glycine-extended gastrin 17 results in increased expression of BIRC5 mRNA] CTD PMID:19153190 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased expression of CCN2 mRNA]
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCN2 mRNA]		 CTD PMID:25740948 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP
ISO		 stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 protein]
stattic affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]		 CTD PMID:30670587 PMID:33396024 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]] CTD PMID:33396024 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 mRNA]] CTD PMID:33396024 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cish cytokine inducible SH2-containing protein multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased expression of CISH mRNA] CTD PMID:26297436 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased expression of COL1A1 mRNA]
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A1 mRNA]		 CTD PMID:25740948 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 protein]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 protein] CTD PMID:30670587 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO stattic inhibits the reaction [EGF protein results in increased expression of PSMB5 protein]; stattic inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein] CTD PMID:24627483 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions ISO stattic inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein] CTD PMID:23255093 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO stattic inhibits the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GPT protein] CTD PMID:28887131 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A protein] CTD PMID:29341321 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO stattic inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein] CTD PMID:29329563 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA] CTD PMID:26297436 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO stattic inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of IL1B mRNA] CTD PMID:22454431 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [stattic co-treated with IL6 protein] results in increased expression of SOCS3 protein; stattic affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein]; stattic inhibits the reaction [IL6 protein results in increased activity of TGFB1 protein]; stattic inhibits the reaction [IL6 protein results in increased expression of APPA mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of CCN2 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of CISH mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of COL1A1 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A protein]; stattic inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
stattic inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]; stattic inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of IL6 mRNA]		 CTD PMID:22454431 PMID:25740948 PMID:26297436 PMID:28739487 PMID:29341321 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO stattic inhibits the reaction [deoxynivalenol results in increased expression of JAK2 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of JAK2 mRNA] CTD PMID:22454431 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein] CTD PMID:24434654 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mir21 microRNA 21 affects expression
multiple interactions		 ISO stattic affects the expression of MIR21 mRNA
stattic affects the reaction [arsenic trichloride affects the expression of MIR21 mRNA]		 CTD PMID:24434654 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO stattic results in decreased expression of MMP10 mRNA CTD PMID:22285823 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:25740948 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO stattic affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; stattic affects the reaction [CXCL8 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]] CTD PMID:33396024 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Psmb1 proteasome 20S subunit beta 1 decreases expression ISO stattic results in decreased expression of PSMB1 mRNA; stattic results in decreased expression of PSMB1 protein CTD PMID:24627483 NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560 		JBrowse link
G Psmb2 proteasome 20S subunit beta 2 decreases expression ISO stattic results in decreased expression of PSMB2 mRNA; stattic results in decreased expression of PSMB2 protein CTD PMID:24627483 NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137 		JBrowse link
G Psmb3 proteasome 20S subunit beta 3 decreases expression ISO stattic results in decreased expression of PSMB3 mRNA; stattic results in decreased expression of PSMB3 protein CTD PMID:24627483 NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521 		JBrowse link
G Psmb4 proteasome 20S subunit beta 4 decreases expression ISO stattic results in decreased expression of PSMB4 mRNA; stattic results in decreased expression of PSMB4 protein CTD PMID:24627483 NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746 		JBrowse link
G Psmb5 proteasome 20S subunit beta 5 decreases expression
multiple interactions		 ISO stattic results in decreased expression of PSMB5 mRNA; stattic results in decreased expression of PSMB5 protein
stattic inhibits the reaction [EGF protein results in increased expression of PSMB5 protein]		 CTD PMID:24627483 NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440 		JBrowse link
G Psmb6 proteasome 20S subunit beta 6 decreases expression ISO stattic results in decreased expression of PSMB6 mRNA; stattic results in decreased expression of PSMB6 protein CTD PMID:24627483 NCBI chr10:55,239,274...55,241,581
Ensembl chr10:55,239,241...55,241,586 		JBrowse link
G Psmb7 proteasome 20S subunit beta 7 decreases expression ISO stattic results in decreased expression of PSMB7 mRNA; stattic results in decreased expression of PSMB7 protein CTD PMID:24627483 NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937 		JBrowse link
G Riox2 ribosomal oxygenase 2 multiple interactions ISO stattic inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of RIOX2 protein] CTD PMID:24434654 NCBI chr11:40,861,365...40,884,782
Ensembl chr11:40,860,774...40,884,574 		JBrowse link
G Skp2 S-phase kinase associated protein 2 multiple interactions EXP stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 protein] CTD PMID:30670587 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 mRNA]] CTD PMID:33396024 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 mRNA]] CTD PMID:33396024 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO [stattic co-treated with IL6 protein] results in increased expression of SOCS3 protein CTD PMID:25740948 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO stattic inhibits the reaction [deoxynivalenol results in increased expression of STAT1 mRNA]; stattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT1 protein]; stattic inhibits the reaction [T-2 Toxin results in increased expression of STAT1 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT1 protein] CTD PMID:22454431 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation		 ISO
EXP		 stattic affects the reaction [Arsenicals affects the phosphorylation of STAT3 protein]; stattic affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein]; stattic inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
Stattic inhibits the reaction [Il-6 increases phosphorylation of STAT3 protein in the stomach)
stattic inhibits the reaction [zoniporide results in increased phosphorylation of STAT3 protein]
stattic inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [deoxynivalenol results in increased expression of STAT3 mRNA]; stattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [T-2 Toxin results in increased expression of STAT3 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein]
stattic results in decreased phosphorylation of STAT3 protein		 CTD PMID:20942815 PMID:22454431 PMID:23255093 PMID:24627483 PMID:25740948 More... RGD:127284846 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased activity of TGFB1 protein]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1 mRNA]
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TGFB1 mRNA]		 CTD PMID:25740948 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO stattic inhibits the reaction [deoxynivalenol results in increased expression of TNF mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of TNF mRNA] CTD PMID:22454431 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions ISO stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 mRNA]] CTD PMID:33396024 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Vim vimentin multiple interactions ISO stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM mRNA]] CTD PMID:33396024 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
tyrphostin B42 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO tyrphostin B42 alone or co-treated with Nimesulide decreases expression of BIRC5 protein in esophagus squamous epithelium RGD PMID:25724470 RGD:127285656 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases cleavage of CASP3 protein in stomach] RGD PMID:32106377 RGD:127284886 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid decreases cleavage of CASP9 protein in stomach] RGD PMID:32106377 RGD:127284886 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Jak2 Janus kinase 2 decreases expression
multiple interactions		 EXP
ISO		 Turphostin B42 decreased expression of Jak2 mRNA in myofibroblasts
tyrphostin B42 inhibits the reaction [cisplatin increases expression of Jak2 mRNA in kidney]
tyrphostin B42 inhibits the reaction [selumetinib increases phosphorylation of JAK2 protein in colonic epithelium]
tyrphostin B42 decreases expression and phosphorylation of JAK2 protein in colonic epithelium
tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases phosphorylation of JAK2 protein in stomach]		 RGD PMID:26385087 PMID:31250048 PMID:30706361 PMID:22050790 PMID:32106377 RGD:18337263, RGD:149735351, RGD:127285668, RGD:127285665, RGD:127284886 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO Tyrphostin B42 alone or co-treated with Nimesulide decreases expression of MT-CO2 protein in esophagus squamous epithelium RGD PMID:25724470 RGD:127285656 Ensembl chr MT:7,006...7,689 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO tyrphostin B42 co-treated with N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases phosphorylation of STAT3 protein in stomach] RGD PMID:32106377 RGD:127284886 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          STAT3 inhibitor 46
            S3I-201 1
            STAT3 inhibitor peptide 0
            stattic 43
            tyrphostin B42 6
paths to the root