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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:antibiotic antifungal drug
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Accession:CHEBI:87113 term browser browse the term
Definition:Any antibiotic antifungal agent used to treat fungal infections in humans or animals.
Synonyms:related_synonym: antibiotic antifungal drugs


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amphotericin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6 interleukin 6 increases expression
multiple interactions		 EXP Amphotericin B results in increased expression of IL6 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]		 CTD PMID:24105867 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
sirolimus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of ATF6 protein] CTD PMID:37659622 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304 		JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2L1 protein] CTD PMID:36754226 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694 		JBrowse link
G BECN1 beclin 1 multiple interactions EXP Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]] CTD PMID:34811946 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased cleavage of CASP3 protein] CTD PMID:37659622 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CLDN1 claudin 1 multiple interactions EXP Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased expression of CLDN1 protein] CTD PMID:36754226 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657 		JBrowse link
G CLDN4 claudin 4 multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in decreased expression of CLDN4 protein] CTD PMID:37659622 NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925 		JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CYCS protein] CTD PMID:37659622 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866 		JBrowse link
G DCTN4 dynactin subunit 4 multiple interactions EXP Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA] CTD PMID:34811946 NCBI chr 2:151,681,001...151,713,923
Ensembl chr 2:151,681,003...151,783,746 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of DDIT3 protein] CTD PMID:37659622 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased phosphorylation of ERN1 protein] CTD PMID:37659622 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284 		JBrowse link
G FGD4 FYVE, RhoGEF and PH domain containing 4 multiple interactions EXP Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]] CTD PMID:34811946 NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028 		JBrowse link
G FIS1 fission, mitochondrial 1 multiple interactions EXP Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of FIS1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]] CTD PMID:34811946 NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,937,453...8,946,955 		JBrowse link
G FOXO1 forkhead box O1 increases expression
affects localization		 EXP Sirolimus results in increased expression of FOXO1 mRNA; Sirolimus results in increased expression of FOXO1 protein
Sirolimus affects the localization of FOXO1 protein		 CTD PMID:20622751 NCBI chr11:15,317,222...15,410,059
Ensembl chr11:15,317,124...15,410,473 		JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA] CTD PMID:34811946 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433 		JBrowse link
G H2AX H2A.X variant histone multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of H2AX protein] CTD PMID:37659622 NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in decreased expression of HSPA5 protein] CTD PMID:37659622 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G IGF2 insulin like growth factor 2 decreases expression EXP Sirolimus results in decreased expression of IGF2 mRNA; Sirolimus results in decreased expression of IGF2 protein CTD PMID:20622751 NCBI chr 2:1,469,183...1,496,417 JBrowse link
G INS insulin multiple interactions
decreases expression		 EXP Sirolimus inhibits the reaction [Glucose results in increased secretion of INS protein]
Sirolimus results in decreased expression of INS mRNA; Sirolimus results in decreased expression of INS protein		 CTD PMID:20622751 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841 		JBrowse link
G LAMP2 lysosomal associated membrane protein 2 multiple interactions EXP Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased expression of LAMP2 protein] CTD PMID:36754226 NCBI chr  X:98,586,718...98,623,939
Ensembl chr  X:98,556,710...98,623,940 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions EXP Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]; Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased lipidation of MAP1LC3B protein] CTD PMID:34811946 PMID:36754226 NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069 		JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased phosphorylation of MTOR protein] CTD PMID:37659622 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions EXP Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of FIS1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of OPA1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]] CTD PMID:34811946 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109 		JBrowse link
G NEUROD1 neuronal differentiation 1 decreases expression EXP Sirolimus results in decreased expression of NEUROD1 mRNA CTD PMID:20622751 NCBI chr15:87,175,629...87,179,953
Ensembl chr15:87,175,765...87,179,959 		JBrowse link
G OCLN occludin multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in decreased expression of OCLN protein] CTD PMID:37659622 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase multiple interactions EXP Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of OPA1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]] CTD PMID:34811946 NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083 		JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 decreases expression EXP Sirolimus results in decreased expression of PDX1 mRNA CTD PMID:20622751 NCBI chr11:5,303,609...5,309,063
Ensembl chr11:5,303,609...5,309,063 		JBrowse link
G SELP selectin P multiple interactions EXP Sirolimus inhibits the reaction [Zymosan analog results in increased expression of SELP protein] CTD PMID:16797888 NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,399,955 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA] CTD PMID:34811946 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
G SQSTM1 sequestosome 1 multiple interactions EXP Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]] CTD PMID:34811946 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938 		JBrowse link
G TJP2 tight junction protein 2 multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in decreased expression of TJP2 protein] CTD PMID:37659622 NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP Sirolimus inhibits the reaction [Zymosan analog results in increased expression of VCAM1 protein] CTD PMID:16797888 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5066
    role 5030
      application 869
        pharmaceutical 719
          drug 719
            antifungal drug 41
              antibiotic antifungal drug 32
                Fungichromin 0
                OSU-03012 0
                amphotericin B + 1
                anidulafungin 0
                candicidin 0
                caspofungin + 0
                caspofungin acetate 0
                cilofungin 0
                fumagillin + 0
                griseofulvin 0
                micafungin 0
                micafungin sodium 0
                natamycin 0
                nystatin 0
                nystatins + 0
                sirolimus + 31
                streptomycin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5066
    subatomic particle 5057
      composite particle 5057
        hadron 5057
          baryon 5057
            nucleon 5057
              atomic nucleus 5057
                atom 5057
                  main group element atom 5026
                    p-block element atom 5023
                      p-block molecular entity 5023
                        carbon group molecular entity 4940
                          organic molecular entity 4939
                            heteroorganic entity 4779
                              antibiotic antifungal agent 35
                                antibiotic antifungal drug 32
                                  Fungichromin 0
                                  OSU-03012 0
                                  amphotericin B + 1
                                  anidulafungin 0
                                  candicidin 0
                                  caspofungin + 0
                                  caspofungin acetate 0
                                  cilofungin 0
                                  fumagillin + 0
                                  griseofulvin 0
                                  micafungin 0
                                  micafungin sodium 0
                                  natamycin 0
                                  nystatin 0
                                  nystatins + 0
                                  sirolimus + 31
                                  streptomycin + 0
paths to the root