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ONTOLOGY REPORT - ANNOTATIONS


Term:quinacrine
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Accession:CHEBI:8711 term browser browse the term
Definition:A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Synonyms:exact_synonym: 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine
 related_synonym: 2-methoxy-6-chloro-9-diethylaminopentylaminoacridine;   3-chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine;   6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine;   Formula=C23H30ClN3O;   InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);   InChIKey=GPKJTRJOBQGKQK-UHFFFAOYSA-N;   N(4)-(6-chloro-2-methoxy-9-acridinyl)-N(1),N(1)-diethyl-1,4-pentanediamine;   SMILES=CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12;   mepacrine
 xref: Beilstein:497807 "Beilstein";   Beilstein:95500 "Beilstein";   CAS:83-89-6 "ChemIDplus";   CAS:83-89-6 "KEGG COMPOUND";   DrugBank:DB01103;   Drug_Central:2338 "DrugCentral";   HMDB:HMDB0015235;   KEGG:C07339;   KEGG:D08179;   LINCS:LSM-1577
 xref_mesh: MESH:D011796
 xref: MetaCyc:ATABRINE;   PMID:11339632 "Europe PMC";   PMID:11908878 "Europe PMC";   PMID:19747949 "Europe PMC";   Reaxys:95500 "Reaxys";   Wikipedia:Quinacrine


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quinacrine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6480464
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:6480464
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mir183 microRNA 183 JBrowse link 4 57,463,569 57,463,678 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Otc ornithine carbamoyltransferase JBrowse link X 13,524,804 13,601,074 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464
G Sp1 Sp1 transcription factor JBrowse link 7 144,014,173 144,044,635 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        aetiopathogenetic role 18761
          genotoxin 16053
            acridine 26
              quinacrine 26
                (R)-quinacrine 0
                (S)-quinacrine 0
                quinacrine mustard + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic molecule 19337
                              organic cyclic compound 19089
                                organic heterocyclic compound 18164
                                  organic heteropolycyclic compound 17427
                                    organic heterotricyclic compound 13734
                                      dibenzopyridine 140
                                        acridines 107
                                          acridine 26
                                            quinacrine 26
                                              (R)-quinacrine 0
                                              (S)-quinacrine 0
                                              quinacrine mustard + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.