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ONTOLOGY REPORT - ANNOTATIONS


Term:quinacrine
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Accession:CHEBI:8711 term browser browse the term
Definition:A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Synonyms:exact_synonym: 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine
 related_synonym: 2-methoxy-6-chloro-9-diethylaminopentylaminoacridine;   3-chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine;   6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine;   Formula=C23H30ClN3O;   InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);   InChIKey=GPKJTRJOBQGKQK-UHFFFAOYSA-N;   N(4)-(6-chloro-2-methoxy-9-acridinyl)-N(1),N(1)-diethyl-1,4-pentanediamine;   SMILES=CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12;   mepacrine
 xref: Beilstein:497807 "Beilstein";   Beilstein:95500 "Beilstein";   CAS:83-89-6 "ChemIDplus";   CAS:83-89-6 "KEGG COMPOUND";   DrugBank:DB01103;   Drug_Central:2338 "DrugCentral";   HMDB:HMDB0015235;   KEGG:C07339;   KEGG:D08179;   LINCS:LSM-1577
 xref_mesh: MESH:D011796
 xref: MetaCyc:ATABRINE;   PMID:11339632 "Europe PMC";   PMID:11908878 "Europe PMC";   PMID:19747949 "Europe PMC";   Reaxys:95500 "Reaxys";   Wikipedia:Quinacrine


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quinacrine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A JBrowse link 5 8,567,091 8,748,575 RGD:6480464
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) JBrowse link 8 124,556,587 124,569,706 RGD:6480464
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6480464
G Btrc beta-transducin repeat containing protein JBrowse link 19 45,363,688 45,533,343 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Casp9 caspase 9 JBrowse link 4 141,793,612 141,815,978 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 7 144,929,931 144,939,937 RGD:6480464
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 61,554,236 61,590,320 RGD:6480464
G Ctnnb1 catenin (cadherin associated protein), beta 1 JBrowse link 9 120,933,400 120,960,507 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 9 57,687,928 57,703,824 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 7 140,763,819 140,774,990 RGD:6480464
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 JBrowse link 5 145,854,607 145,879,854 RGD:6480464
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 JBrowse link 5 137,892,933 137,925,610 RGD:6480464
G Foxp3 forkhead box P3 JBrowse link X 7,579,676 7,595,243 RGD:6480464
G Gli1 GLI-Kruppel family member GLI1 JBrowse link 10 127,329,882 127,341,579 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 16 38,089,001 38,246,084 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 2 129,299,609 129,310,186 RGD:6480464
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 JBrowse link 5 24,319,589 24,351,684 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Mir183 microRNA 183 JBrowse link 6 30,169,668 30,169,737 RGD:6480464
G Myc myelocytomatosis oncogene JBrowse link 15 61,985,341 61,990,361 RGD:6480464
G Otc ornithine transcarbamylase JBrowse link X 10,252,230 10,321,024 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase family, member 1 JBrowse link 1 180,568,891 180,600,999 RGD:6480464
G Prl prolactin JBrowse link 13 27,057,570 27,065,204 RGD:6480464
G Sp1 trans-acting transcription factor 1 JBrowse link 15 102,406,316 102,436,404 RGD:6480464
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20752
    role 20730
      biological role 20729
        aetiopathogenetic role 19759
          genotoxin 16547
            acridine 27
              quinacrine 27
                (R)-quinacrine 0
                (S)-quinacrine 0
                quinacrine mustard + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20752
    subatomic particle 20745
      composite particle 20745
        hadron 20745
          baryon 20745
            nucleon 20745
              atomic nucleus 20745
                atom 20745
                  main group element atom 20665
                    p-block element atom 20665
                      carbon group element atom 20401
                        carbon atom 20377
                          organic molecular entity 20377
                            organic molecule 20225
                              organic cyclic compound 19912
                                organic heterocyclic compound 18868
                                  organic heteropolycyclic compound 18271
                                    organic heterotricyclic compound 14502
                                      dibenzopyridine 140
                                        acridines 106
                                          acridine 27
                                            quinacrine 27
                                              (R)-quinacrine 0
                                              (S)-quinacrine 0
                                              quinacrine mustard + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.