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ONTOLOGY REPORT - ANNOTATIONS


Term:quinacrine
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Accession:CHEBI:8711 term browser browse the term
Definition:A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Synonyms:exact_synonym: 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine
 related_synonym: 2-methoxy-6-chloro-9-diethylaminopentylaminoacridine;   3-chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine;   6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine;   Formula=C23H30ClN3O;   InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);   InChIKey=GPKJTRJOBQGKQK-UHFFFAOYSA-N;   N(4)-(6-chloro-2-methoxy-9-acridinyl)-N(1),N(1)-diethyl-1,4-pentanediamine;   SMILES=CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12;   mepacrine
 xref: Beilstein:497807 "Beilstein";   Beilstein:95500 "Beilstein";   CAS:83-89-6 "ChemIDplus";   CAS:83-89-6 "KEGG COMPOUND";   DrugBank:DB01103;   Drug_Central:2338 "DrugCentral";   HMDB:HMDB0015235;   KEGG:C07339;   KEGG:D08179;   LINCS:LSM-1577
 xref_mesh: MESH:D011796
 xref: MetaCyc:ATABRINE;   PMID:11339632 "Europe PMC";   PMID:11908878 "Europe PMC";   PMID:19747949 "Europe PMC";   Reaxys:95500 "Reaxys";   Wikipedia:Quinacrine


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quinacrine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB1 ATP binding cassette subfamily B member 1 JBrowse link 7 87,503,017 87,713,323 RGD:6480464
G AGT angiotensinogen JBrowse link 1 230,702,523 230,714,122 RGD:6480464
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 48,954,825 48,961,798 RGD:6480464
G BTRC beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 10 101,353,808 101,557,321 RGD:6480464
G CASP3 caspase 3 JBrowse link 4 184,627,696 184,649,475 RGD:6480464
G CASP9 caspase 9 JBrowse link 1 15,491,401 15,524,912 RGD:6480464
G CCND1 cyclin D1 JBrowse link 11 69,641,156 69,654,474 RGD:6480464
G CSNK1A1 casein kinase 1 alpha 1 JBrowse link 5 149,492,982 149,551,439 RGD:6480464
G CTNNB1 catenin beta 1 JBrowse link 3 41,199,422 41,240,445 RGD:6480464
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 JBrowse link 15 74,719,542 74,725,528 RGD:6480464
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 JBrowse link 10 133,527,363 133,539,123 RGD:6480464
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 JBrowse link 7 99,756,967 99,784,184 RGD:6480464
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 JBrowse link 7 99,648,194 99,679,996 RGD:6480464
G FOXP3 forkhead box P3 JBrowse link X 49,250,436 49,264,932 RGD:6480464
G GLI1 GLI family zinc finger 1 JBrowse link 12 57,459,785 57,472,451 RGD:6480464
G GSK3B glycogen synthase kinase 3 beta JBrowse link 3 119,821,321 120,095,823 RGD:6480464
G IL1A interleukin 1 alpha JBrowse link 2 112,773,925 112,784,493 RGD:6480464
G KCNH2 potassium voltage-gated channel subfamily H member 2 JBrowse link 7 150,944,956 150,978,321 RGD:6480464
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 22 21,759,657 21,867,680 RGD:6480464
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 16 30,114,105 30,123,309 RGD:6480464
G MIR183 microRNA 183 JBrowse link 7 129,774,905 129,775,014 RGD:6480464
G MYC MYC proto-oncogene, bHLH transcription factor JBrowse link 8 127,735,434 127,742,951 RGD:6480464
G OTC ornithine carbamoyltransferase JBrowse link X 38,352,528 38,421,446 RGD:6480464
G PARP1 poly(ADP-ribose) polymerase 1 JBrowse link 1 226,360,691 226,408,093 RGD:6480464
G PRL prolactin JBrowse link 6 22,287,246 22,302,897 RGD:6480464
G SP1 Sp1 transcription factor JBrowse link 12 53,380,176 53,416,446 RGD:6480464
G TP53 tumor protein p53 JBrowse link 17 7,668,402 7,687,550 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23673
    role 23561
      biological role 23522
        aetiopathogenetic role 22189
          genotoxin 17227
            acridine 27
              quinacrine 27
                (R)-quinacrine 0
                (S)-quinacrine 0
                quinacrine mustard + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 23673
    subatomic particle 23620
      composite particle 23620
        hadron 23620
          baryon 23620
            nucleon 23620
              atomic nucleus 23620
                atom 23620
                  main group element atom 23437
                    p-block element atom 23437
                      carbon group element atom 23135
                        carbon atom 23111
                          organic molecular entity 23111
                            organic molecule 22967
                              organic cyclic compound 21936
                                organic heterocyclic compound 20567
                                  organic heteropolycyclic compound 19638
                                    organic heterotricyclic compound 14162
                                      dibenzopyridine 139
                                        acridines 105
                                          acridine 27
                                            quinacrine 27
                                              (R)-quinacrine 0
                                              (S)-quinacrine 0
                                              quinacrine mustard + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.