bridged diphenyl fungicide - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	bridged diphenyl fungicide	go back to main search page
Accession:	CHEBI:87039	browse the term
Definition:	Any organic aromatic compound containing two phenyl (or substituted phenyl) groups attached to a single carbon or heteroatom and which has been used as a fungicide.
Synonyms:	related_synonym:	bridged diphenyl fungicides

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Rat (1266) Mouse (1317) Human (1286) Chinchilla (0) Bonobo (0) Dog (3) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (1266)

4'-hydroxydiclofenac

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

4'-hydroxydiclofenac binds to and affects the activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

C-C motif chemokine ligand 2

increases expression

4'-hydroxydiclofenac results in increased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

[[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

estrogen receptor 1

affects activity

4'-hydroxydiclofenac affects the activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

glutathione S-transferase pi 1

increases glutathionylation
multiple interactions

GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac
[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]

PMID:24246759 PMID:24552538

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

interleukin 10

multiple interactions

4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 2

multiple interactions

4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein]

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

multiple interactions

4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL4 protein]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions

4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

myeloperoxidase

multiple interactions

4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; 4'-hydroxydiclofenac promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein]; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 4'-hydroxydiclofenac

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

multiple interactions

NQO2 protein results in increased reduction of and results in decreased glutathionylation of 4'-hydroxydiclofenac

NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

4'-hydroxydiclofenac binds to and affects the activity of NR3C1 protein

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

tumor necrosis factor

increases response to substance
multiple interactions

TNF protein results in increased susceptibility to 4'-hydroxydiclofenac
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]

PMID:23939143 PMID:29777833

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

5-hydroxydiclofenac

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

[CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

[CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

[CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

[[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

multiple interactions

[CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

glutathione S-transferase pi 1

multiple interactions

[[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

myeloperoxidase

multiple interactions

[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 5-hydroxydiclofenac

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

aceclofenac

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ADAM metallopeptidase domain 17

increases response to substance

ADAM17 results in increased susceptibility to aceclofenac

NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639

G

growth differentiation factor 15

increases expression

aceclofenac results in increased expression of GDF15 protein
aceclofenac results in increased expression of GDF15 mRNA

PMID:15555568 PMID:18076062

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

selectin L

decreases expression

aceclofenac results in decreased expression of SELL protein

NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456

G

tumor necrosis factor

multiple interactions

[aceclofenac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

bithionol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

iodotyrosine deiodinase

multiple interactions

Bithionol inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]

NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319

G

solute carrier family 22 member 2

multiple interactions

Bithionol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

thyroid hormone receptor alpha

increases activity

Bithionol results in increased activity of THRA protein

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

thyroid hormone receptor beta

increases activity

Bithionol results in increased activity of THRB protein

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

tumor protein p53

affects activity

Bithionol affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

Dichlorophen

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

iodotyrosine deiodinase

multiple interactions

Dichlorophen inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]

NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319

G

tumor protein p53

affects activity

Dichlorophen affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

diclofenac

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

increases expression

Diclofenac results in increased expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

alpha-2-macroglobulin-like 1

increases expression

Diclofenac results in increased expression of A2ML1 mRNA

NCBI chr 4:161,815,111...161,857,286
Ensembl chr 4:161,814,708...161,857,343

G

acetoacetyl-CoA synthetase

decreases expression

Diclofenac results in decreased expression of AACS mRNA

NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954

G

alanyl-tRNA synthetase 1

decreases expression

Diclofenac results in decreased expression of AARS1 mRNA

NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

Diclofenac inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Diclofenac results in decreased activity of ABCB11 protein

PMID:24014644 PMID:28437613

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

increases expression
decreases response to substance
decreases activity

Diclofenac results in increased expression of ABCB1B mRNA
ABCB1A gene mutant form results in decreased susceptibility to Diclofenac
Diclofenac results in decreased activity of ABCB1A protein

PMID:15458769 PMID:19022234 PMID:28193520

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

decreases expression

Diclofenac results in decreased expression of ABCB1B mRNA

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily B member 4

decreases expression
decreases activity

Diclofenac results in decreased expression of ABCB4 mRNA
Diclofenac results in decreased activity of ABCB4 protein

PMID:19022234 PMID:28437613

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 2

decreases activity
increases expression
multiple interactions

Diclofenac results in decreased activity of ABCC2 protein
Diclofenac results in increased expression of ABCC2 mRNA
ABCC2 protein results in increased transport of and results in increased metabolism of and results in increased susceptibility to Diclofenac

PMID:19022234 PMID:22646477 PMID:25450747

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 4

affects expression

Diclofenac affects the expression of ABCC4 mRNA

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ABL proto-oncogene 2, non-receptor tyrosine kinase

affects expression

Diclofenac affects the expression of ABL2 mRNA

NCBI chr13:68,673,702...68,770,846
Ensembl chr13:68,673,722...68,839,742

G

angiotensin converting enzyme 2

decreases expression

Diclofenac results in decreased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

apoptotic chromatin condensation inducer 1

affects expression

Diclofenac affects the expression of ACIN1 mRNA

NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001

G

atypical chemokine receptor 3

decreases expression

Diclofenac results in decreased expression of ACKR3 mRNA

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237

G

acyl-CoA thioesterase 2

decreases expression

Diclofenac results in decreased expression of ACOT2 mRNA

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

acyl-CoA oxidase 1

increases expression

Diclofenac results in increased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

acid phosphatase 3

increases expression

Diclofenac results in increased expression of ACP3 mRNA

NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236

G

actin, alpha 1, skeletal muscle

affects expression

Diclofenac affects the expression of ACTA1 mRNA

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

actin-like 9

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of ACTL9 mRNA

NCBI chr 7:14,234,504...14,235,881
Ensembl chr 7:14,234,504...14,235,881

G

actinin, alpha 1

affects expression

Diclofenac affects the expression of ACTN1 mRNA

NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251

G

activin A receptor type 1

affects expression

Diclofenac affects the expression of ACVR1 mRNA

NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241

G

activin A receptor type 1B

affects expression
multiple interactions

Diclofenac affects the expression of ACVR1B mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ACVR1B mRNA

PMID:24752500 PMID:37844793

NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673

G

activin A receptor type 2B

affects expression

Diclofenac affects the expression of ACVR2B mRNA

NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458

G

ADAM-like, decysin 1

increases expression

Diclofenac results in increased expression of ADAMDEC1 mRNA

NCBI chr15:42,900,629...42,921,684
Ensembl chr15:42,900,636...42,921,712

G

adenylate cyclase 6

affects expression

Diclofenac affects the expression of ADCY6 mRNA

NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754

G

adenylate cyclase 9

affects expression
decreases expression

Diclofenac affects the expression of ADCY9 mRNA
Diclofenac results in decreased expression of ADCY9 mRNA

PMID:24752500 PMID:26934552

NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

increases expression

Diclofenac results in increased expression of ADH1 protein

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

decreases expression

Diclofenac results in decreased expression of ADH7 mRNA

NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182

G

adenosine kinase

increases expression
decreases expression

Diclofenac results in increased expression of ADK mRNA
Diclofenac results in decreased expression of ADK mRNA

NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510

G

adenosine A2a receptor

increases expression

Diclofenac results in increased expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adenosine A2B receptor

increases expression

Diclofenac results in increased expression of ADORA2B mRNA

NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772

G

adrenoceptor beta 2

increases expression

Diclofenac results in increased expression of ADRB2 mRNA

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

apoptosis enhancing nuclease

increases expression

Diclofenac results in increased expression of AEN mRNA

NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523

G

advanced glycosylation end product-specific receptor

increases expression

Diclofenac results in increased expression of AGER mRNA

PMID:24747151 PMID:28138970

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

angiogenic factor with G patch and FHA domains 1

affects expression

Diclofenac affects the expression of AGGF1 mRNA

NCBI chr 2:26,619,336...26,646,050
Ensembl chr 2:26,619,339...26,645,952

G

argonaute RISC catalytic component 2

affects expression

Diclofenac affects the expression of AGO2 mRNA

NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974

G

argonaute RISC catalytic component 3

affects expression

Diclofenac affects the expression of AGO3 mRNA

NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230

G

argonaute RISC component 4

affects expression

Diclofenac affects the expression of AGO4 mRNA

NCBI chr 5:138,780,446...138,825,898
Ensembl chr 5:138,783,069...138,825,632

G

agouti related neuropeptide

increases expression

Diclofenac results in increased expression of AGRP mRNA

NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584

G

aryl hydrocarbon receptor

increases expression

Diclofenac results in increased expression of AHR mRNA

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

alpha-2-HS-glycoprotein

multiple interactions

[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of AHSG protein

NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999

G

apoptosis inducing factor, mitochondria associated 1

affects expression

Diclofenac affects the expression of AIFM1 mRNA

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

absent in melanoma 2

increases expression

Diclofenac results in increased expression of AIM2 mRNA

NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975

G

AT-hook transcription factor

decreases expression

Diclofenac results in decreased expression of AKNA mRNA

NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017

G

aldo-keto reductase family 1, member B7

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of AKR1B7 mRNA

NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502

G

AKT serine/threonine kinase 1

affects expression

Diclofenac affects the expression of AKT1 mRNA

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

affects expression

Diclofenac affects the expression of AKT2 mRNA

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

5'-aminolevulinate synthase 1

decreases expression

Diclofenac results in decreased expression of ALAS1 mRNA

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

5'-aminolevulinate synthase 2

affects expression

Diclofenac affects the expression of ALAS2 mRNA

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519

G

albumin

affects binding
increases expression
decreases expression
multiple interactions
decreases secretion

Diclofenac binds to ALB protein
Diclofenac results in increased expression of ALB mRNA
Diclofenac results in decreased expression of ALB protein
[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein; Quercetin inhibits the reaction [[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein]
Diclofenac results in decreased secretion of ALB protein

PMID:9353694 PMID:19022234 PMID:28400101 PMID:36442613

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 18 family, member A1

increases expression
decreases expression

Diclofenac results in increased expression of ALDH18A1 mRNA
Diclofenac results in decreased expression of ALDH18A1 mRNA

PMID:26934552 PMID:35537566

NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890

G

aldehyde dehydrogenase 1 family, member B1

increases expression

Diclofenac results in increased expression of ALDH1B1 mRNA

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 1 family, member L2

decreases expression

Diclofenac results in decreased expression of ALDH1L2 mRNA

NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776

G

aldehyde dehydrogenase 3 family, member A2

decreases expression

Diclofenac results in decreased expression of ALDH3A2 mRNA

NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281

G

aldolase, fructose-bisphosphate C

increases expression

Diclofenac results in increased expression of ALDOC mRNA

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

arachidonate 15-lipoxygenase

increases expression
multiple interactions

Diclofenac results in increased expression of ALOX15 mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ALOX15 mRNA

PMID:23939143 PMID:37844793

NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874

G

anti-Mullerian hormone

increases expression
multiple interactions

Diclofenac results in increased expression of AMH mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of AMH mRNA

PMID:35537566 PMID:37844793

NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282

G

angiomotin like 2

decreases expression

Diclofenac results in decreased expression of AMOTL2 mRNA

NCBI chr 8:103,303,368...103,319,161
Ensembl chr 8:103,302,992...103,318,910

G

angiogenin

increases expression

Diclofenac results in increased expression of ANG mRNA

NCBI chr15:24,312,711...24,323,361

G

annexin A8

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ANXA8 mRNA

NCBI chr16:9,397,144...9,412,072
Ensembl chr16:9,397,113...9,412,043

G

amine oxidase, copper containing 3

decreases expression

Diclofenac results in decreased expression of AOC3 mRNA

NCBI chr10:86,272,757...86,280,702

G

apoptotic peptidase activating factor 1

affects expression

Diclofenac affects the expression of APAF1 mRNA

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

amyloid P component, serum

multiple interactions
increases expression

[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APCS protein
Diclofenac results in increased expression of APCS mRNA; Diclofenac results in increased expression of APCS protein

PMID:25772430 PMID:26934552

NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298

G

apolipoprotein A4

affects expression

Diclofenac affects the expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

aquaporin 2

decreases expression

Diclofenac results in decreased expression of AQP2 protein

NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468

G

aquaporin 9

decreases expression

Diclofenac results in decreased expression of AQP9 mRNA

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

aquarius intron-binding spliceosomal factor

affects expression

Diclofenac affects the expression of AQR mRNA

NCBI chr 3:100,874,987...100,945,026
Ensembl chr 3:100,874,987...100,945,044

G

androgen receptor

affects activity

Diclofenac affects the activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

A-Raf proto-oncogene, serine/threonine kinase

affects expression

Diclofenac affects the expression of ARAF mRNA

NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073

G

Rho GTPase activating protein 20

increases expression

Diclofenac results in increased expression of ARHGAP20 mRNA

NCBI chr 8:52,074,472...52,155,739
Ensembl chr 8:52,074,158...52,155,739

G

Rho GTPase activating protein 26

affects expression

Diclofenac affects the expression of ARHGAP26 mRNA

NCBI chr18:30,835,806...31,237,945
Ensembl chr18:30,838,671...31,235,194

G

Rho/Rac guanine nucleotide exchange factor 2

affects expression

Diclofenac affects the expression of ARHGEF2 mRNA

NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355

G

Rho guanine nucleotide exchange factor 3

affects expression
decreases expression

Diclofenac affects the expression of ARHGEF3 mRNA
Diclofenac results in decreased expression of ARHGEF3 mRNA

PMID:24752500 PMID:35537566

NCBI chr16:2,301,573...2,581,951
Ensembl chr16:2,300,138...2,581,945

G

Rho guanine nucleotide exchange factor 7

affects expression

Diclofenac affects the expression of ARHGEF7 mRNA

NCBI chr16:77,671,021...77,782,593
Ensembl chr16:77,671,023...77,782,697

G

AT-rich interaction domain 4A

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ARID4A mRNA

NCBI chr 6:89,522,459...89,593,868
Ensembl chr 6:89,522,442...89,593,510

G

AT-rich interaction domain 5A

decreases expression

Diclofenac results in decreased expression of ARID5A mRNA

NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597

G

AT-rich interaction domain 5B

decreases expression

Diclofenac results in decreased expression of ARID5B mRNA

NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433

G

ADP-ribosylation factor like GTPase 11

decreases expression

Diclofenac results in decreased expression of ARL11 mRNA

NCBI chr15:35,483,330...35,485,579
Ensembl chr15:35,480,018...35,496,596

G

armadillo repeat containing, X-linked 1

increases expression

Diclofenac results in increased expression of ARMCX1 mRNA

NCBI chr X:97,898,969...97,902,874
Ensembl chr X:97,898,883...97,903,299

G

aryl hydrocarbon receptor nuclear translocator

affects expression

Diclofenac affects the expression of ARNT mRNA

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

arrestin, beta 1

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ARRB1 mRNA

NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061

G

arrestin domain containing 3

increases expression

Diclofenac results in increased expression of ARRDC3 mRNA

NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978

G

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

affects expression

Diclofenac affects the expression of ASAP1 mRNA

NCBI chr 7:95,786,130...96,093,111
Ensembl chr 7:95,787,818...96,092,754

G

ASH2 like histone lysine methyltransferase complex subunit

affects expression

Diclofenac affects the expression of ASH2L mRNA

NCBI chr16:66,242,205...66,264,064
Ensembl chr16:66,242,212...66,264,061

G

acid sensing ion channel subunit 1

decreases expression

Diclofenac results in decreased expression of ASIC1 mRNA

NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541

G

acid sensing ion channel subunit 2

decreases expression

Diclofenac results in decreased expression of ASIC2 mRNA

NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424

G

acid sensing ion channel subunit 3

decreases expression
decreases activity

Diclofenac results in decreased expression of ASIC3 mRNA
Diclofenac results in decreased activity of ASIC3 protein

NCBI chr 4:10,760,509...10,764,987
Ensembl chr 4:10,760,597...10,764,643

G

argininosuccinate lyase

affects expression

Diclofenac affects the expression of ASL mRNA

NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression
increases expression

Diclofenac results in decreased expression of ASNS mRNA
Diclofenac results in increased expression of ASNS mRNA

PMID:19192274 PMID:26934552 PMID:35537566

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

argininosuccinate synthase 1

decreases expression

Diclofenac results in decreased expression of ASS1 mRNA

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

activating transcription factor 2

affects expression

Diclofenac affects the expression of ATF2 mRNA

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

G

activating transcription factor 4

affects expression
decreases expression
increases expression

Diclofenac affects the expression of ATF4 mRNA
Diclofenac results in decreased expression of ATF4 mRNA
Diclofenac results in increased expression of ATF4 mRNA

PMID:24752500 PMID:27313093 PMID:35537566

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 5

decreases expression

Diclofenac results in decreased expression of ATF5 mRNA

NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707

G

ATPase phospholipid transporting 11A

increases expression

Diclofenac results in increased expression of ATP11A mRNA

NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640

G

ATP synthase F1 subunit alpha

multiple interactions
increases expression

[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1A protein
Diclofenac results in increased expression of ATP5F1A protein

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

ATP synthase F1 subunit beta

multiple interactions
increases expression

[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1B protein
Diclofenac results in increased expression of ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase peripheral stalk subunit F6

multiple interactions
increases expression

[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5PF protein
Diclofenac results in increased expression of ATP5PF protein

NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119

G

antizyme inhibitor 1

affects expression

Diclofenac affects the expression of AZIN1 mRNA

NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578

G

Beta-1,3-galactosyltransferase 1

increases expression

Diclofenac results in increased expression of B3GALT1 mRNA

NCBI chr 3:52,253,413...52,826,508
Ensembl chr 3:52,253,618...52,825,313

G

BTB domain and CNC homolog 1

affects expression

Diclofenac affects the expression of BACH1 mRNA

NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447

G

BCL2-antagonist/killer 1

increases activity

Diclofenac results in increased activity of BAK1 protein

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BRCA1 associated RING domain 1

affects expression

Diclofenac affects the expression of BARD1 mRNA

NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265

G

BCL2 associated X, apoptosis regulator

increases activity
increases expression
affects localization

Diclofenac results in increased activity of BAX protein
Diclofenac results in increased expression of BAX mRNA
Diclofenac affects the localization of BAX protein

PMID:18191430 PMID:29027214

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCAR3 adaptor protein, NSP family member

decreases expression

Diclofenac results in decreased expression of BCAR3 mRNA

NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798

G

BCL2, apoptosis regulator

increases expression

Diclofenac results in increased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

decreases expression

Diclofenac results in decreased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 1

increases expression
affects expression

Diclofenac results in increased expression of BCL2L1 mRNA alternative form
Diclofenac affects the expression of BCL2L1 mRNA

PMID:14609740 PMID:24752500

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

Bcl2-like 11

affects expression

Diclofenac affects the expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

BCL3, transcription coactivator

increases expression

Diclofenac results in increased expression of BCL3 mRNA

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

G

BCL6, transcription repressor

decreases expression

Diclofenac results in decreased expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

3-hydroxybutyrate dehydrogenase 1

decreases expression

Diclofenac results in decreased expression of BDH1 mRNA

NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671

G

BH3 interacting domain death agonist

multiple interactions
affects expression
increases activity

1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Diclofenac results in increased activity of BID protein]
Diclofenac affects the expression of BID mRNA

PMID:18191430 PMID:24752500

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

bone morphogenetic protein 4

affects expression

Diclofenac affects the expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

bone morphogenetic protein 6

decreases expression
increases expression

Diclofenac results in decreased expression of BMP6 mRNA
Diclofenac results in increased expression of BMP6 mRNA

PMID:26934552 PMID:32816093

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

B-Raf proto-oncogene, serine/threonine kinase

affects expression

Diclofenac affects the expression of BRAF mRNA

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

BRCA1, DNA repair associated

increases expression

Diclofenac results in increased expression of BRCA1 mRNA

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

BRCA2, DNA repair associated

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of BRCA2 mRNA

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

G

BRD3 opposite strand

decreases expression

Diclofenac results in decreased expression of BRD3OS mRNA

NCBI chr 3:10,770,229...10,771,860

G

bromodomain testis associated

decreases expression

Diclofenac results in decreased expression of BRDT mRNA

NCBI chr14:2,387,372...2,445,857
Ensembl chr14:2,387,796...2,445,842

G

BRCA1 interacting helicase 1

affects expression

Diclofenac affects the expression of BRIP1 mRNA

NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324

G

BTG anti-proliferation factor 1

decreases expression

Diclofenac results in decreased expression of BTG1 mRNA

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

complement C1q A chain

increases expression

Diclofenac results in increased expression of C1QA mRNA

NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534

G

complement C1q B chain

increases expression

Diclofenac results in increased expression of C1QB mRNA

NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407

G

complement C1q C chain

increases expression

Diclofenac results in increased expression of C1QC mRNA

NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017

G

complement C2

increases expression

Diclofenac results in increased expression of C2 mRNA

NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505

G

complement C4B

increases expression

Diclofenac results in increased expression of C4B mRNA

NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681

G

calcium voltage-gated channel subunit alpha1 B

decreases expression

Diclofenac results in decreased expression of CACNA1B mRNA

NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091

G

calcitonin-related polypeptide alpha

decreases expression

Diclofenac results in decreased expression of CALCA mRNA

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

calmodulin 1

affects expression

Diclofenac affects the expression of CALM1 mRNA

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

G

calmodulin-like 3

increases expression

Diclofenac results in increased expression of CALML3 mRNA

NCBI chr17:66,419,844...66,423,083
Ensembl chr17:66,419,882...66,423,175

G

calreticulin

affects expression
decreases expression

Diclofenac affects the expression of CALR mRNA
Diclofenac results in decreased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

calcium/calmodulin-dependent protein kinase ID

increases expression

Diclofenac results in increased expression of CAMK1D mRNA

NCBI chr17:72,581,899...72,982,704
Ensembl chr17:72,581,979...72,980,556

G

calcium/calmodulin-dependent protein kinase II beta

increases expression

Diclofenac results in increased expression of CAMK2B mRNA

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

G

cathelicidin antimicrobial peptide

increases expression

Diclofenac results in increased expression of CAMP mRNA

NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543

G

calpain 10

affects expression

Diclofenac affects the expression of CAPN10 mRNA

NCBI chr 9:93,498,132...93,510,494
Ensembl chr 9:93,498,478...93,510,494

G

carbonic anhydrase 1

decreases expression

Diclofenac results in decreased expression of CAR1 mRNA

NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208

G

carbonic anhydrase 13

decreases expression

Diclofenac results in decreased expression of CAR13 mRNA

NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525

G

carbonic anhydrase 3

decreases expression
increases secretion

Diclofenac results in decreased expression of CAR3 mRNA
Diclofenac results in increased secretion of CAR3 protein

PMID:24038040 PMID:26934552

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

cysteinyl-tRNA synthetase 1

decreases expression

Diclofenac results in decreased expression of CARS1 mRNA

NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941

G

caspase 1

multiple interactions
increases cleavage

diacerein inhibits the reaction [Diclofenac results in increased cleavage of CASP1 protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased cleavage of CASP1 protein]

PMID:25450234 PMID:38582345

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 2

multiple interactions
affects expression

Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP2 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP2 protein]
Diclofenac affects the expression of CASP2 mRNA

PMID:16388830 PMID:24752500

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

increases activity
multiple interactions

Diclofenac results in increased activity of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP3 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]
2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; [Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein; alpha-Tocopherol inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein]; Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]

PMID:12826271 PMID:14599462 PMID:14609740 PMID:16388830 PMID:24770551 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

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caspase 6

affects expression

Diclofenac affects the expression of CASP6 mRNA

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

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caspase 8

increases activity
affects expression
multiple interactions

Diclofenac results in increased activity of CASP8 protein
Diclofenac affects the expression of CASP8 mRNA
[Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP8 protein; [TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]

PMID:14609740 PMID:20237495 PMID:24752500 PMID:27313093

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

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caspase 9

multiple interactions
increases expression
increases activity

[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP9 protein]
Diclofenac results in increased expression of CASP9 mRNA

PMID:14609740 PMID:16388830 PMID:25014874 PMID:27313093 PMID:29027214

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

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catalase

increases activity
decreases activity
multiple interactions

Diclofenac results in increased activity of CAT protein
Diclofenac results in decreased activity of CAT protein
Ondansetron promotes the reaction [Diclofenac results in decreased activity of CAT protein]
[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [Diclofenac results in decreased activity of CAT protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in decreased activity of CAT protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Diclofenac results in decreased activity of CAT protein]

PMID:17274466 PMID:23994749 PMID:28535741 PMID:31042592 PMID:31332906

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

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Cbl proto-oncogene

affects expression

Diclofenac affects the expression of CBL mRNA

NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176

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carbonyl reductase 1

affects expression

Diclofenac affects the expression of CBR1 mRNA

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

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cystathionine beta synthase

affects expression

Diclofenac affects the expression of CBS mRNA

NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764

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coiled-coil domain containing 137

increases expression

Diclofenac results in increased expression of CCDC137 mRNA

NCBI chr10:105,730,776...105,737,158
Ensembl chr10:105,730,739...105,737,158

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C-C motif chemokine ligand 2

multiple interactions
increases secretion
increases expression
affects expression

[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein]
Diclofenac analog results in increased secretion of CCL2 protein
SB 203580 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]; U 0126 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]
Diclofenac results in increased expression of CCL2 protein
Diclofenac affects the expression of CCL2 mRNA
Diclofenac results in increased expression of CCL2 mRNA

PMID:22285467 PMID:23939143 PMID:24104198 PMID:25051504 PMID:27671914 More...

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

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C-C motif chemokine ligand 3

multiple interactions
decreases expression

Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA]
Diclofenac results in decreased expression of CCL3 mRNA

PMID:23939143 PMID:35537566

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

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C-C motif chemokine ligand 9

increases expression

Diclofenac results in increased expression of CCL6 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

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cellular communication network factor 1

affects expression
increases expression

Diclofenac affects the expression of CCN1 mRNA
Diclofenac results in increased expression of CCN1 mRNA

PMID:19192274 PMID:24752500

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

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cyclin D1

multiple interactions
affects expression
decreases expression
increases expression

Diclofenac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]
Diclofenac affects the expression of CCND1 mRNA
Diclofenac results in decreased expression of CCND1 mRNA
Diclofenac results in increased expression of CCND1 mRNA
Diclofenac results in decreased expression of CCND1 protein

PMID:15188006 PMID:15489888 PMID:19022234 PMID:26934552

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

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cyclin D3

affects expression

Diclofenac affects the expression of CCND3 mRNA

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

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cyclin E1

affects expression

Diclofenac affects the expression of CCNE1 mRNA

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

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cyclin E2

affects expression

Diclofenac affects the expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

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cyclin F

affects expression

Diclofenac affects the expression of CCNF mRNA

NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101

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cyclin G1

increases expression

Diclofenac results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cyclin H

affects expression

Diclofenac affects the expression of CCNH mRNA

NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819

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C-C motif chemokine receptor 1

increases expression

Diclofenac results in increased expression of CCR1 mRNA

NCBI chr 8:123,556,286...123,561,841

G

C-C motif chemokine receptor 5

increases expression

Diclofenac results in increased expression of CCR5 mRNA

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

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CD14 molecule

increases expression

Diclofenac results in increased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

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CD163 molecule

increases expression

Diclofenac results in increased expression of CD163 mRNA

NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878

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CD200 receptor 1-like

decreases expression

Diclofenac results in decreased expression of CD200R4 mRNA

NCBI chr11:55,842,632...55,860,914
Ensembl chr11:55,842,634...55,885,680

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CD244 molecule

decreases expression

Diclofenac results in decreased expression of CD244 mRNA

NCBI chr13:84,051,339...84,082,864
Ensembl chr13:84,052,493...84,074,492

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Cd28 molecule

increases expression

Diclofenac results in increased expression of CD28 mRNA

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

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CD44 molecule

increases expression

Diclofenac results in increased expression of CD44 mRNA

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

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CD55 molecule (Cromer blood group)

increases expression

Diclofenac results in increased expression of CD55 mRNA

NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831

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Cd5 molecule-like

increases expression

Diclofenac results in increased expression of CD5L mRNA

NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753

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CD9 molecule

increases expression

Diclofenac results in increased expression of CD9 mRNA

NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222

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CDC42 effector protein 5

decreases expression

Diclofenac results in decreased expression of CDC42EP5 mRNA

NCBI chr 1:70,035,921...70,038,990

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cell division cycle 6

affects expression

Diclofenac affects the expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

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cell division cycle 7

affects expression

Diclofenac affects the expression of CDC7 mRNA

NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778

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cell division cycle associated 5

increases expression

Diclofenac results in increased expression of CDCA5 mRNA

NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023

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cadherin 1

increases expression
affects expression
decreases expression

Diclofenac results in increased expression of CDH1 protein
Diclofenac affects the expression of CDH1 mRNA
Diclofenac results in decreased expression of CDH1 mRNA

PMID:19022234 PMID:19628293 PMID:24752500

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin dependent kinase 2

affects expression

Diclofenac affects the expression of CDK2 mRNA

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 5

affects expression

Diclofenac affects the expression of CDK5 mRNA

NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112

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cyclin-dependent kinase 5 regulatory subunit 1

increases expression

Diclofenac results in increased expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

cyclin-dependent kinase 6

affects expression

Diclofenac affects the expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase 7

affects expression

Diclofenac affects the expression of CDK7 mRNA

NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383

G

cyclin-dependent kinase inhibitor 1A

increases expression

Diclofenac results in increased expression of CDKN1A mRNA

PMID:19022234 PMID:26934552

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

affects expression

Diclofenac affects the expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

chromatin licensing and DNA replication factor 1

affects expression

Diclofenac affects the expression of CDT1 mRNA

NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659

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CCAAT/enhancer binding protein beta

increases expression
affects expression

Diclofenac results in increased expression of CEBPB mRNA
Diclofenac affects the expression of CEBPB mRNA

PMID:19022234 PMID:24752500

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

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CCAAT/enhancer binding protein gamma

decreases expression

Diclofenac results in decreased expression of CEBPG mRNA

NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569

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centrosomal protein 162

decreases expression

Diclofenac results in decreased expression of CEP162 mRNA

NCBI chr 8:88,149,726...88,208,249
Ensembl chr 8:88,149,726...88,206,830

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ceramide synthase 6

increases expression

Diclofenac results in increased expression of CERS6 mRNA

NCBI chr 3:53,630,637...53,879,692
Ensembl chr 3:53,630,959...53,876,848

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carboxylesterase 1D

decreases expression

Diclofenac results in decreased expression of CES1D mRNA

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

CFAP97 domain containing 1

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of CFAP97D1 mRNA

NCBI chr10:86,933,585...86,944,566
Ensembl chr10:86,933,808...86,938,244

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complement factor H

increases expression

Diclofenac results in increased expression of CFH mRNA

NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838

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CASP8 and FADD-like apoptosis regulator

multiple interactions
affects expression

[Diclofenac co-treated with Hyaluronic Acid] results in decreased expression of CFLAR protein
Diclofenac affects the expression of CFLAR mRNA

PMID:20237495 PMID:24752500

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

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cell growth regulator with EF hand domain 1

decreases expression

Diclofenac results in decreased expression of CGREF1 mRNA

NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852

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ChaC glutathione-specific gamma-glutamylcyclotransferase 1

increases expression
decreases expression

Diclofenac results in increased expression of CHAC1 mRNA
Diclofenac results in decreased expression of CHAC1 mRNA

PMID:26934552 PMID:35537566

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

coiled-coil-helix-coiled-coil-helix domain containing 1

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of CHCHD1 mRNA

NCBI chr15:3,592,719...3,593,901
Ensembl chr15:3,592,727...3,593,901

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choline dehydrogenase

affects expression

Diclofenac affects the expression of CHDH mRNA

NCBI chr16:5,194,269...5,225,541
Ensembl chr16:5,194,269...5,225,537

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checkpoint kinase 1

affects expression

Diclofenac affects the expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

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choline kinase alpha

affects expression

Diclofenac affects the expression of CHKA mRNA

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516

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choline kinase beta

affects expression

Diclofenac affects the expression of CHKB mRNA

NCBI chr 7:120,500,960...120,504,359
Ensembl chr 7:120,500,984...120,504,461

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cell adhesion molecule L1-like

increases expression

Diclofenac results in increased expression of CHL1 mRNA

NCBI chr 4:136,291,504...136,505,830
Ensembl chr 4:136,291,463...136,503,265

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carbohydrate sulfotransferase 4

decreases expression

Diclofenac results in decreased expression of CHST4 mRNA

NCBI chr19:37,993,471...38,002,123
Ensembl chr19:37,991,417...38,003,608

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component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Diclofenac inhibits the reaction [TNF protein results in increased activity of CHUK protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of CHUK protein]

PMID:15489888 PMID:25935278

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

calcium and integrin binding 1

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of CIB1 mRNA

NCBI chr 1:134,178,331...134,183,895
Ensembl chr 1:134,178,331...134,213,423

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C-type lectin domain family 4, member A

increases expression

Diclofenac results in increased expression of CLEC4N mRNA

NCBI chr 4:156,340,439...156,434,212
Ensembl chr 4:156,414,688...156,432,402

G

clusterin

increases expression
multiple interactions

Diclofenac results in increased expression of CLU protein
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CLU protein

PMID:23506792 PMID:25772430

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

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cytidine/uridine monophosphate kinase 2

affects expression

Diclofenac affects the expression of CMPK2 mRNA

NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183

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collagen type III alpha 1 chain

decreases expression
multiple interactions

Diclofenac results in decreased expression of COL3A1 mRNA
[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein]

PMID:26934552 PMID:31042592

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

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coactosin-like F-actin binding protein 1

increases expression

Diclofenac results in increased expression of COTL1 mRNA

NCBI chr19:47,871,689...47,906,010
Ensembl chr19:47,871,694...47,911,689

G

cytochrome c oxidase subunit 4i2

increases expression

Diclofenac results in increased expression of COX4I2 mRNA

NCBI chr 3:141,228,443...141,239,337
Ensembl chr 3:141,228,443...141,239,331

G

cytochrome c oxidase subunit 6A2

decreases expression

Diclofenac results in decreased expression of COX6A2 mRNA

NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274

G

carboxypeptidase B2

increases expression

Diclofenac results in increased expression of CPB2 mRNA

NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556

G

complexin 1

increases expression

Diclofenac results in increased expression of CPLX1 mRNA

NCBI chr14:1,184,677...1,216,392

G

complexin 4

increases expression

Diclofenac results in increased expression of CPLX4 mRNA

NCBI chr18:59,481,360...59,504,716
Ensembl chr18:59,481,986...59,497,778

G

copine 8

increases expression

Diclofenac results in increased expression of CPNE8 mRNA

NCBI chr 7:121,615,293...121,789,507
Ensembl chr 7:121,615,294...121,790,377

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cleavage and polyadenylation specific factor 6

affects expression

Diclofenac affects the expression of CPSF6 mRNA

NCBI chr 7:52,956,589...53,001,783
Ensembl chr 7:52,956,589...52,988,122

G

carnitine palmitoyltransferase 1A

increases expression

Diclofenac results in increased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

complement C3b/C4b receptor 1 like

multiple interactions

[Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein]

NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445

G

complement C3d receptor 2

affects expression

Diclofenac affects the expression of CR2 mRNA

NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235

G

cAMP responsive element binding protein 3-like 2

increases expression

Diclofenac results in increased expression of CREB3L2 mRNA

NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763

G

cAMP responsive element binding protein 3-like 4

affects expression

Diclofenac affects the expression of CREB3L4 mRNA

NCBI chr 2:175,690,340...175,695,846
Ensembl chr 2:175,690,335...175,695,932

G

C-reactive protein

multiple interactions
decreases expression

[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CRP protein; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CRP protein]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Diclofenac results in decreased expression of CRP protein]
Diclofenac inhibits the reaction [TNF protein results in increased expression of CRP mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CRP protein]

PMID:25772430 PMID:27313093

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

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cryptochrome circadian regulator 1

decreases expression

Diclofenac results in decreased expression of CRY1 mRNA

NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091

G

colony stimulating factor 1

decreases expression

Diclofenac results in decreased expression of CSF1 mRNA

PMID:26934552 PMID:35537566

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

colony stimulating factor 1 receptor

increases expression
increases secretion

Diclofenac results in increased expression of CSF1R mRNA
Diclofenac results in increased secretion of CSF1R protein

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

colony stimulating factor 2 receptor subunit beta

increases expression

Diclofenac results in increased expression of CSF2RB mRNA; Diclofenac results in increased expression of CSF2RB2 mRNA

NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157

G

casein kinase 2 alpha 1

affects expression

Diclofenac affects the expression of CSNK2A1 mRNA

NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696

G

casein kinase 2 alpha 2

affects expression

Diclofenac affects the expression of CSNK2A2 mRNA

NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080

G

cysteine and serine rich nuclear protein 3

increases expression

Diclofenac results in increased expression of CSRNP3 mRNA

NCBI chr 3:50,498,379...50,695,598
Ensembl chr 3:50,498,633...50,685,950

G

cleavage stimulation factor subunit 2

affects expression

Diclofenac affects the expression of CSTF2 mRNA

NCBI chr X:97,253,559...97,279,476
Ensembl chr X:97,253,586...97,279,476

G

cleavage stimulation factor subunit 3

affects expression

Diclofenac affects the expression of CSTF3 mRNA

NCBI chr 3:90,966,415...91,037,669
Ensembl chr 3:90,966,354...91,042,196

G

C-terminal binding protein 2

affects expression

Diclofenac affects the expression of CTBP2 mRNA

NCBI chr 1:187,782,064...187,918,115
Ensembl chr 1:187,782,682...187,920,222

G

cystathionine gamma-lyase

affects expression
decreases expression

Diclofenac affects the expression of CTH mRNA
Diclofenac results in decreased expression of CTH mRNA

PMID:24752500 PMID:35537566

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

cytotoxic T-lymphocyte-associated protein 4

increases expression

Diclofenac results in increased expression of CTLA4 protein

NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963

G

catenin beta 1

affects expression

Diclofenac affects the expression of CTNNB1 mRNA

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

CTP synthase 1

affects expression

Diclofenac affects the expression of CTPS1 mRNA

NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180

G

CTP synthase 2

affects expression

Diclofenac affects the expression of CTPS2 mRNA

NCBI chr X:31,645,873...31,786,733
Ensembl chr X:31,645,873...31,786,733

G

cathepsin C

increases expression

Diclofenac results in increased expression of CTSC mRNA

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

G

cathepsin E

decreases expression

Diclofenac results in decreased expression of CTSE mRNA

NCBI chr13:43,091,954...43,114,509
Ensembl chr13:43,092,128...43,114,502

G

cathepsin S

increases expression

Diclofenac results in increased expression of CTSS mRNA

NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483

G

cullin 3

affects expression

Diclofenac affects the expression of CUL3 mRNA

NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462

G

cullin 7

decreases expression

Diclofenac results in decreased expression of CUL7 mRNA

NCBI chr 9:14,319,102...14,333,035
Ensembl chr 9:14,319,108...14,332,741

G

C-X-C motif chemokine ligand 1

multiple interactions

Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 protein]

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 13

increases expression

Diclofenac results in increased expression of CXCL13 mRNA

NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933

G

C-X-C motif chemokine ligand 14

increases expression

Diclofenac results in increased expression of CXCL14 mRNA

NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839

G

C-X-C motif chemokine ligand 2

multiple interactions
increases expression

Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL2 mRNA]
Diclofenac results in increased expression of CXCL2 mRNA; Diclofenac results in increased expression of CXCL2 protein

PMID:22285467 PMID:23939143 PMID:24747151 PMID:26934552 PMID:27671914

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

increases expression
decreases expression

Diclofenac results in increased expression of CXCL1 mRNA; Diclofenac results in increased expression of CXCL1 protein
Diclofenac results in decreased expression of CXCL1 mRNA

PMID:26934552 PMID:27671914

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine receptor 4

decreases expression

Diclofenac results in decreased expression of CXCR4 mRNA

PMID:19192274 PMID:35537566

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome b-561

increases expression

Diclofenac results in increased expression of CYB561 mRNA

NCBI chr10:90,878,052...90,888,734
Ensembl chr10:90,878,054...90,884,787

G

cytochrome b-245 alpha chain

increases expression

Diclofenac results in increased expression of CYBA mRNA

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome b-245 beta chain

increases expression

Diclofenac results in increased expression of CYBB mRNA

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome c, somatic

affects expression

Diclofenac affects the expression of CYCS mRNA

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases expression

Diclofenac results in increased expression of CYP17A1 mRNA

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of CYP19A1 mRNA

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
decreases activity

Diclofenac results in increased expression of CYP1A1 mRNA; Diclofenac results in increased expression of CYP1A1 protein
Diclofenac results in decreased activity of CYP1A1 protein

PMID:18420780 PMID:21784029

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression
decreases activity
multiple interactions

Diclofenac results in increased expression of CYP1A2 mRNA; Diclofenac results in increased expression of CYP1A2 protein
Diclofenac metabolite results in decreased activity of CYP1A2 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac

PMID:21784029 PMID:23397584 PMID:28960974

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Diclofenac results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 26, subfamily a, polypeptide 1

decreases expression

Diclofenac results in decreased expression of CYP26A1 mRNA

NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204

G

cytochrome P450, family 26, subfamily b, polypeptide 1

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of CYP26B1 mRNA

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

G

cytochrome P450, family 2, subfamily a, polypeptide 3

decreases activity
affects expression

Diclofenac results in decreased activity of CYP2A4 protein
Diclofenac affects the expression of CYP2A4 mRNA

PMID:18420780 PMID:26934552

NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases activity

Diclofenac results in decreased activity of CYP2B10 protein

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily c, polypeptide 24

decreases expression

Diclofenac results in decreased expression of CYP2C55 mRNA

NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases hydroxylation
decreases activity
increases response to substance
multiple interactions

CYP2C6 protein results in increased hydroxylation of Diclofenac
Diclofenac results in decreased activity of CYP2C29 protein
CYP2C19 protein results in increased susceptibility to Diclofenac
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2C19 protein co-treated with CYP2C9 protein] results in increased hydroxylation of Diclofenac
CYP2C19 protein results in increased hydroxylation of Diclofenac

PMID:11911841 PMID:15486075 PMID:18420780 PMID:18511451 PMID:23397584 More...

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 7

affects metabolic processing

CYP2C9 protein affects the metabolism of Diclofenac

NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

[[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac

PMID:23397584 PMID:24246759

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

Diclofenac metabolite results in decreased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 39, subfamily a, polypeptide 1

increases expression

Diclofenac results in increased expression of CYP39A1 mRNA

NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
increases metabolic processing
increases expression
multiple interactions
increases response to substance

Diclofenac metabolite results in decreased activity of CYP3A4 protein; Diclofenac results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased metabolism of Diclofenac
Diclofenac results in increased expression of CYP3A4 mRNA
[[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein co-treated with UGT2B7 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac
CYP3A4 protein results in increased susceptibility to Diclofenac

PMID:15135088 PMID:19022234 PMID:23397584 PMID:24104198 PMID:24246759 More...

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression

Diclofenac results in increased expression of CYP3A23-3A1 mRNA

PMID:19022234 PMID:29027214

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

decreases activity
increases expression

Diclofenac metabolite results in decreased activity of CYP3A13 protein
Diclofenac results in increased expression of CYP3A13 mRNA

PMID:26934552 PMID:28960974

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 46, subfamily a, polypeptide 1

increases hydroxylation

CYP46A1 protein results in increased hydroxylation of Diclofenac

NCBI chr 6:127,247,543...127,274,765
Ensembl chr 6:127,243,315...127,274,760

G

cytochrome P450, family 4, subfamily f, polypeptide 39

decreases expression

Diclofenac results in decreased expression of CYP4F39 mRNA

NCBI chr 7:11,426,806...11,505,553
Ensembl chr 7:11,433,371...11,536,181

G

cytochrome P450, family 4, subfamily v, polypeptide 3

decreases expression

Diclofenac results in decreased expression of CYP4V3 mRNA

NCBI chr16:46,917,929...46,958,735
Ensembl chr16:46,918,401...46,943,395

G

cytochrome P450, family 51

decreases activity
increases expression

Diclofenac metabolite results in decreased activity of CYP51A1 protein
Diclofenac results in increased expression of CYP51 mRNA

PMID:26934552 PMID:28960974

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

cytochrome P450 family 7 subfamily A member 1

increases expression

Diclofenac results in increased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

Diclofenac results in decreased expression of CYP8B1 mRNA

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

death-associated protein

increases expression

Diclofenac results in increased expression of DAP mRNA

NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752

G

dihydrolipoamide branched chain transacylase E2

affects expression

Diclofenac affects the expression of DBT mRNA

NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:204,481,737...204,510,609

G

dCTP pyrophosphatase 1

affects expression

Diclofenac affects the expression of DCTPP1 mRNA

NCBI chr 1:181,877,440...181,880,833
Ensembl chr 1:181,877,437...181,880,839

G

DNA-damage inducible transcript 3

increases response to substance
decreases expression
increases expression

DDIT3 results in increased susceptibility to Diclofenac
Diclofenac results in decreased expression of DDIT3 mRNA
Diclofenac results in increased expression of DDIT3 mRNA; Diclofenac results in increased expression of DDIT3 protein

PMID:18172885 PMID:20668000 PMID:24752500 PMID:27313093 PMID:27358234 More...

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

increases expression

Diclofenac results in increased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

discoidin domain receptor tyrosine kinase 1

affects expression

Diclofenac affects the expression of DDR1 mRNA

NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468

G

D-dopachrome tautomerase

decreases expression

Diclofenac results in decreased expression of DDT mRNA

NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482

G

DEAD-box helicase 5

affects expression

Diclofenac affects the expression of DDX5 mRNA

NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283

G

2,4-dienoyl-CoA reductase 1

increases expression

Diclofenac results in increased expression of DECR1 protein

NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018

G

DENN domain containing 2D

decreases expression

Diclofenac results in decreased expression of DENND2D mRNA

NCBI chr 2:193,973,231...193,992,275
Ensembl chr 2:193,973,231...193,992,270

G

derlin 1

increases expression

Diclofenac results in increased expression of DERL1 mRNA

NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145

G

derlin 3

increases expression

Diclofenac results in increased expression of DERL3 mRNA

NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027

G

DNA fragmentation factor subunit alpha

affects expression

Diclofenac affects the expression of DFFA mRNA

NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633

G

24-dehydrocholesterol reductase

increases expression

Diclofenac results in increased expression of DHCR24 mRNA

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

dihydrofolate reductase

affects expression

Diclofenac affects the expression of DHFR mRNA

NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713

G

dehydrogenase/reductase 3

decreases expression

Diclofenac results in decreased expression of DHRS3 mRNA

NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417

G

dickkopf WNT signaling pathway inhibitor 1

affects expression

Diclofenac affects the expression of DKK1 mRNA

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

dynein, axonemal, assembly factor 2

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of DNAAF2 mRNA

NCBI chr 6:87,661,101...87,670,267
Ensembl chr 6:87,660,821...87,670,199

G

DnaJ heat shock protein family (Hsp40) member A1

affects expression

Diclofenac affects the expression of DNAJA1 mRNA

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

DnaJ heat shock protein family (Hsp40) member A2

affects expression

Diclofenac affects the expression of DNAJA2 mRNA

NCBI chr19:21,497,792...21,516,904
Ensembl chr19:21,497,729...21,516,901

G

DnaJ heat shock protein family (Hsp40) member A3

affects expression
decreases expression

Diclofenac affects the expression of DNAJA3 mRNA
Diclofenac results in decreased expression of DNAJA3 mRNA

PMID:24752500 PMID:26934552

NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161

G

DnaJ heat shock protein family (Hsp40) member B1

affects expression

Diclofenac affects the expression of DNAJB1 mRNA

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B14

affects expression

Diclofenac affects the expression of DNAJB14 mRNA

NCBI chr 2:226,358,988...226,409,461
Ensembl chr 2:226,358,996...226,402,490

G

DnaJ heat shock protein family (Hsp40) member B4

affects expression

Diclofenac affects the expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

DnaJ heat shock protein family (Hsp40) member B6

affects expression

Diclofenac affects the expression of DNAJB6 mRNA

NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659

G

DnaJ heat shock protein family (Hsp40) member B7

increases expression

Diclofenac results in increased expression of DNAJB7 mRNA

NCBI chr 7:112,932,736...112,934,050
Ensembl chr 7:112,932,616...112,945,537

G

DnaJ heat shock protein family (Hsp40) member B9

affects expression
increases expression

Diclofenac affects the expression of DNAJB9 mRNA
Diclofenac results in increased expression of DNAJB9 mRNA

PMID:24752500 PMID:26934552

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

DnaJ heat shock protein family (Hsp40) member C10

affects expression
increases expression

Diclofenac affects the expression of DNAJC10 mRNA
Diclofenac results in increased expression of DNAJC10 mRNA

PMID:24752500 PMID:26934552

NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719

G

DnaJ heat shock protein family (Hsp40) member C11

affects expression

Diclofenac affects the expression of DNAJC11 mRNA

NCBI chr 5:162,442,042...162,487,966
Ensembl chr 5:162,442,026...162,488,169

G

DnaJ heat shock protein family (Hsp40) member C12

increases expression
decreases expression

Diclofenac results in increased expression of DNAJC12 mRNA
Diclofenac results in decreased expression of DNAJC12 mRNA

NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521

G

DnaJ heat shock protein family (Hsp40) member C15

affects expression

Diclofenac affects the expression of DNAJC15 mRNA

NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675

G

DnaJ heat shock protein family (Hsp40) member C18

affects expression

Diclofenac affects the expression of DNAJC18 mRNA

NCBI chr18:27,269,350...27,303,453
Ensembl chr18:27,269,355...27,298,344

G

DnaJ heat shock protein family (Hsp40) member C21

affects expression

Diclofenac affects the expression of DNAJC21 mRNA

NCBI chr 2:59,419,507...59,446,746
Ensembl chr 2:59,419,510...59,446,752

G

DnaJ heat shock protein family (Hsp40) member C3

increases expression

Diclofenac results in increased expression of DNAJC3 mRNA

NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181

G

DnaJ heat shock protein family (Hsp40) member C5

affects expression

Diclofenac affects the expression of DNAJC5 mRNA

NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935

G

DnaJ heat shock protein family (Hsp40) member C6

affects expression

Diclofenac affects the expression of DNAJC6 mRNA

NCBI chr 5:116,120,069...116,283,448
Ensembl chr 5:116,119,676...116,283,448

G

DnaJ heat shock protein family (Hsp40) member C7

affects expression

Diclofenac affects the expression of DNAJC7 mRNA

NCBI chr10:85,518,637...85,555,079
Ensembl chr10:85,518,621...85,555,575

G

DnaJ heat shock protein family (Hsp40) member C8

affects expression

Diclofenac affects the expression of DNAJC8 mRNA

NCBI chr 5:144,745,055...144,763,106
Ensembl chr 5:144,745,036...144,763,108

G

DnaJ heat shock protein family (Hsp40) member C9

affects expression

Diclofenac affects the expression of DNAJC9 mRNA

NCBI chr15:3,923,842...3,928,118
Ensembl chr15:3,923,268...3,928,118

G

DND microRNA-mediated repression inhibitor 1

increases expression

Diclofenac results in increased expression of DND1 mRNA

NCBI chr18:28,378,692...28,381,316
Ensembl chr18:28,378,692...28,381,316

G

delta/notch-like EGF repeat containing

decreases expression

Diclofenac results in decreased expression of DNER mRNA

NCBI chr 9:85,586,985...85,902,461
Ensembl chr 9:85,586,987...85,902,637

G

dihydropyrimidinase-like 2

affects expression

Diclofenac affects the expression of DPYSL2 mRNA

NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829

G

dopamine receptor D1

increases expression

Diclofenac results in increased expression of DRD1 mRNA

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

deoxythymidylate kinase

affects expression

Diclofenac affects the expression of DTYMK mRNA

NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870

G

dual specificity phosphatase 1

affects expression
decreases expression

Diclofenac affects the expression of DUSP1 mRNA
Diclofenac results in decreased expression of DUSP1 mRNA

PMID:24752500 PMID:26934552

NCBI chr10:16,680,478...16,683,275

G

deoxyuridine triphosphatase

affects expression

Diclofenac affects the expression of DUT mRNA

NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771

G

dynein cytoplasmic 1 intermediate chain 1

increases expression

Diclofenac results in increased expression of DYNC1I1 mRNA

NCBI chr 4:33,852,597...34,166,159
Ensembl chr 4:33,852,927...34,166,149

G

E2F transcription factor 1

affects expression

Diclofenac affects the expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 2

affects expression

Diclofenac affects the expression of E2F2 mRNA

NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217

G

E2F transcription factor 5

affects expression

Diclofenac affects the expression of E2F5 mRNA

NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990

G

endogenous Bornavirus like nucleoprotein 1

increases expression

Diclofenac results in increased expression of IGKV8-24 mRNA

NCBI chr10:78,938,645...78,940,651

G

extracellular matrix protein 1

decreases expression

Diclofenac results in decreased expression of ECM1 mRNA

NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671

G

epithelial cell transforming 2

increases expression

Diclofenac results in increased expression of ECT2 mRNA

NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911

G

ER degradation enhancing alpha-mannosidase like protein 1

increases expression

Diclofenac results in increased expression of EDEM1 mRNA

NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717

G

EGF like repeats and discoidin domains 3

decreases expression

Diclofenac results in decreased expression of EDIL3 mRNA

NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008

G

endothelin 1

multiple interactions

Diclofenac inhibits the reaction [EDN1 protein results in decreased transport of Potassium]

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin 2

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of EDN2 mRNA

NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814

G

eukaryotic elongation factor-2 kinase

decreases expression

Diclofenac results in decreased expression of EEF2K mRNA

NCBI chr 1:175,393,119...175,456,756
Ensembl chr 1:175,393,154...175,455,164

G

epidermal growth factor

increases expression

Diclofenac results in increased expression of EGF protein

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

increases expression

Diclofenac results in increased expression of EGFR mRNA

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

increases expression
multiple interactions
affects expression

Diclofenac results in increased expression of EGR1 mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of EGR1 mRNA
Diclofenac affects the expression of EGR1 mRNA

PMID:15509713 PMID:26934552 PMID:37844793

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 1

affects expression

Diclofenac affects the expression of EIF1 mRNA

NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327

G

eukaryotic translation initiation factor 1A

increases expression

Diclofenac results in increased expression of EIF1A mRNA

NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696

G

eukaryotic translation initiation factor 1A, X-linked

affects expression

Diclofenac affects the expression of EIF1AX mRNA

NCBI chr X:35,498,698...35,513,402
Ensembl chr X:35,498,517...35,513,335

G

eukaryotic translation initiation factor 2A

affects expression

Diclofenac affects the expression of EIF2A mRNA

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

eukaryotic translation initiation factor 2 alpha kinase 1

affects expression
decreases expression

Diclofenac affects the expression of EIF2AK1 mRNA
Diclofenac results in decreased expression of EIF2AK1 mRNA

PMID:24752500 PMID:26934552

NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573

G

eukaryotic translation initiation factor 2 alpha kinase 3

affects expression
increases expression
increases phosphorylation
multiple interactions
increases activity

Diclofenac affects the expression of EIF2AK3 mRNA
Diclofenac results in increased expression of EIF2AK3 mRNA
Diclofenac results in increased phosphorylation of EIF2AK3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]
Diclofenac results in increased activity of EIF2AK3 protein

PMID:24752500 PMID:26609140 PMID:26934552

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 alpha kinase 4

affects expression

Diclofenac affects the expression of EIF2AK4 mRNA

NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630

G

eukaryotic translation initiation factor 2B subunit alpha

affects expression

Diclofenac affects the expression of EIF2B1 mRNA

NCBI chr12:32,025,593...32,033,848
Ensembl chr12:32,025,557...32,046,601

G

eukaryotic translation initiation factor 2 subunit alpha

affects expression
multiple interactions

Diclofenac affects the expression of EIF2S1 mRNA
[TNF protein co-treated with Diclofenac] results in increased phosphorylation of EIF2S1 protein

PMID:24752500 PMID:27313093

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 2 subunit beta

affects expression

Diclofenac affects the expression of EIF2S2 mRNA

NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432

G

eukaryotic translation initiation factor 3, subunit A

affects expression

Diclofenac affects the expression of EIF3A mRNA

NCBI chr 1:259,902,767...259,932,976
Ensembl chr 1:259,902,680...259,932,976

G

eukaryotic translation initiation factor 3, subunit B

affects expression

Diclofenac affects the expression of EIF3B mRNA

NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886

G

eukaryotic translation initiation factor 3, subunit C

affects expression

Diclofenac affects the expression of EIF3C mRNA

NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493

G

eukaryotic translation initiation factor 4A1

affects expression

Diclofenac affects the expression of EIF4A1 mRNA

NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858

G

eukaryotic translation initiation factor 4A2

affects expression

Diclofenac affects the expression of EIF4A2 mRNA

NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781

G

eukaryotic translation initiation factor 4E binding protein 1

increases expression
decreases expression
affects expression

Diclofenac results in increased expression of EIF4EBP1 mRNA
Diclofenac results in decreased expression of EIF4EBP1 mRNA
Diclofenac affects the expression of EIF4EBP1 mRNA

PMID:18172885 PMID:24752500 PMID:35537566

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

eukaryotic translation initiation factor 4 gamma 1

affects expression

Diclofenac affects the expression of EIF4G1 mRNA

NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941

G

eukaryotic translation initiation factor 4 gamma, 3

affects expression

Diclofenac affects the expression of EIF4G3 mRNA

NCBI chr 5:150,197,410...150,418,862
Ensembl chr 5:150,195,226...150,418,363

G

eukaryotic translation initiation factor 5

affects expression

Diclofenac affects the expression of EIF5 mRNA

NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656

G

E74 like ETS transcription factor 2

affects expression

Diclofenac affects the expression of ELF2 mRNA

NCBI chr 2:135,292,291...135,385,942
Ensembl chr 2:135,294,906...135,385,947

G

E74 like ETS transcription factor 3

affects expression

Diclofenac affects the expression of ELF3 mRNA

NCBI chr13:46,690,460...46,695,394
Ensembl chr13:46,690,466...46,695,481

G

ELOVL fatty acid elongase 2

affects expression

Diclofenac affects the expression of ELOVL2 mRNA

NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848

G

ELOVL fatty acid elongase 6

increases expression

Diclofenac results in increased expression of ELOVL6 mRNA

NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186

G

essential meiotic structure-specific endonuclease subunit 2

increases expression

Diclofenac results in increased expression of EME2 mRNA

NCBI chr10:13,913,216...13,915,991
Ensembl chr10:13,913,221...13,915,968

G

endonuclease G

affects expression

Diclofenac affects the expression of ENDOG mRNA

NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932

G

enolase 1

increases expression

Diclofenac results in increased expression of ENO1 mRNA

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

affects expression

Diclofenac affects the expression of ENPP1 mRNA

NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

increases expression

Diclofenac results in increased expression of ENPP2 mRNA

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

ectonucleoside triphosphate diphosphohydrolase 4

affects expression

Diclofenac affects the expression of ENTPD4 mRNA

NCBI chr15:44,630,878...44,658,654
Ensembl chr15:44,630,873...44,658,706

G

ectonucleoside triphosphate diphosphohydrolase 5

affects expression

Diclofenac affects the expression of ENTPD5 mRNA

NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530

G

ectonucleoside triphosphate diphosphohydrolase 7

affects expression

Diclofenac affects the expression of ENTPD7 mRNA

NCBI chr 1:242,559,365...242,601,044
Ensembl chr 1:242,559,365...242,601,447

G

endothelial PAS domain protein 1

decreases expression

Diclofenac results in decreased expression of EPAS1 protein

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

enhancer of polycomb homolog 2

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of EPC2 mRNA

NCBI chr 3:33,867,219...33,967,908
Ensembl chr 3:33,867,219...33,967,150

G

epoxide hydrolase 1

decreases expression

Diclofenac results in decreased expression of EPHX1 mRNA

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

epsin 2

affects expression

Diclofenac affects the expression of EPN2 mRNA

NCBI chr10:46,197,785...46,259,673
Ensembl chr10:46,197,785...46,259,642

G

epsin 3

affects expression

Diclofenac affects the expression of EPN3 mRNA

NCBI chr10:79,438,978...79,449,516
Ensembl chr10:79,438,978...79,447,356

G

erythropoietin

affects expression

Diclofenac affects the expression of EPO mRNA

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

erb-b2 receptor tyrosine kinase 4

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ERBB4 mRNA

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

epiregulin

increases expression

Diclofenac results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

endoplasmic reticulum to nucleus signaling 1

affects expression

Diclofenac affects the expression of ERN1 mRNA

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

Diclofenac results in increased expression of ERO1A mRNA

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

G

estrogen receptor 1

affects activity

Diclofenac affects the activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

ethanolamine-phosphate phospho-lyase

decreases expression

Diclofenac results in decreased expression of ETNPPL mRNA

NCBI chr 2:219,173,048...219,194,646
Ensembl chr 2:219,172,978...219,192,212

G

ecotropic viral integration site 5

decreases expression

Diclofenac results in decreased expression of EVI5 mRNA

NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678

G

exostosin-like glycosyltransferase 1

decreases expression

Diclofenac results in decreased expression of EXTL1 mRNA

NCBI chr 5:146,573,911...146,589,115
Ensembl chr 5:146,573,912...146,589,115

G

EYA transcriptional coactivator and phosphatase 4

decreases expression

Diclofenac results in decreased expression of EYA4 mRNA

NCBI chr 1:22,172,275...22,415,978
Ensembl chr 1:22,172,275...22,415,976

G

coagulation factor XIII A1 chain

increases expression

Diclofenac results in increased expression of F13A1 mRNA

NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700

G

FA core complex associated protein 24

increases expression

Diclofenac results in increased expression of FAAP24 mRNA

NCBI chr 1:88,051,523...88,057,997
Ensembl chr 1:88,051,911...88,057,989

G

fatty acid binding protein 1

decreases expression
increases expression

Diclofenac results in decreased expression of FABP1 mRNA
Diclofenac results in increased expression of FABP1 protein

PMID:19022234 PMID:23506792

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

fatty acid binding protein 2

decreases expression

Diclofenac results in decreased expression of FABP2 mRNA

PMID:19022234 PMID:26934552

NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089

G

fatty acid binding protein 3

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FABP3 mRNA

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

G

fatty acid binding protein 4

decreases expression

Diclofenac results in decreased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid binding protein 5

increases expression

Diclofenac results in increased expression of FABP5 mRNA

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773

G

fatty acid desaturase 1

decreases expression

Diclofenac results in decreased expression of FADS1 mRNA

NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734

G

family with sequence similarity 209

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FAM209 mRNA

NCBI chr 3:161,240,062...161,241,747
Ensembl chr 3:161,240,034...161,241,755

G

FA complementation group B

affects expression

Diclofenac affects the expression of FANCB mRNA

NCBI chr X:29,403,771...29,420,484
Ensembl chr X:29,403,771...29,420,192

G

FA complementation group C

affects expression

Diclofenac affects the expression of FANCC mRNA

NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376

G

FA complementation group E

increases expression

Diclofenac results in increased expression of FANCE mRNA

NCBI chr20:6,369,416...6,386,631
Ensembl chr20:6,375,573...6,386,631

G

FA complementation group F

affects expression

Diclofenac affects the expression of FANCF mRNA

NCBI chr 1:101,449,120...101,451,936
Ensembl chr 1:101,450,389...101,451,923

G

FA complementation group G

affects expression

Diclofenac affects the expression of FANCG mRNA

NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029

G

FA complementation group L

affects expression

Diclofenac affects the expression of FANCL mRNA

NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255

G

FA complementation group M

affects expression

Diclofenac affects the expression of FANCM mRNA

NCBI chr 6:83,126,903...83,180,455
Ensembl chr 6:83,127,093...83,180,028

G

Fas cell surface death receptor

affects expression
increases expression

Diclofenac affects the expression of FAS mRNA
Diclofenac results in increased expression of FAS mRNA

PMID:24752500 PMID:26934552

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression

Diclofenac results in increased expression of FASL mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

decreases expression

Diclofenac results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

Fas-activated serine/threonine kinase

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FASTK mRNA

NCBI chr 4:10,732,273...10,736,332
Ensembl chr 4:10,732,256...10,737,430

G

FAST kinase domains 2

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FASTKD2 mRNA

NCBI chr 9:65,166,148...65,188,184
Ensembl chr 9:65,168,228...65,188,174

G

F-box protein 33

increases expression

Diclofenac results in increased expression of FBXO33 mRNA

NCBI chr 6:76,900,619...76,934,232
Ensembl chr 6:76,900,631...76,932,669

G

F-box protein 5

decreases expression

Diclofenac results in decreased expression of FBXO5 mRNA

NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437

G

Fc epsilon receptor Ig

increases expression

Diclofenac results in increased expression of FCER1G mRNA

NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443

G

Fc gamma receptor 2A

increases expression

Diclofenac results in increased expression of FCGR3 mRNA

NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967

G

Fc gamma receptor 2B

decreases expression

Diclofenac results in decreased expression of FCGR2B mRNA

NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778

G

flap structure-specific endonuclease 1

increases expression

Diclofenac results in increased expression of FEN1 mRNA

NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003

G

FER tyrosine kinase

affects expression

Diclofenac affects the expression of FER mRNA

NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451

G

FERM domain containing kindlin 1

increases expression

Diclofenac results in increased expression of FERMT1 mRNA

NCBI chr 3:120,171,301...120,213,555
Ensembl chr 3:120,171,561...120,213,555

G

fibrinogen beta chain

multiple interactions
increases expression

[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGB protein
Diclofenac results in increased expression of FGB mRNA

PMID:25772430 PMID:26934552

NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979

G

fibroblast growth factor 1

decreases expression

Diclofenac results in decreased expression of FGF1 mRNA

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor 3

increases expression

Diclofenac results in increased expression of FGF3 mRNA

NCBI chr 1:200,001,162...200,005,539
Ensembl chr 1:200,001,261...200,005,187

G

Fibroblast growth factor receptor 1

affects expression

Diclofenac affects the expression of FGFR1 mRNA

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

FGFR1 oncogene partner 2

decreases expression

Diclofenac results in decreased expression of FGFR1OP2 mRNA

NCBI chr 4:179,491,602...179,512,630
Ensembl chr 4:179,491,599...179,512,630

G

fibrinogen gamma chain

multiple interactions
decreases expression

[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGG protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FGG protein]; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in decreased expression of FGG protein]

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

fibrinogen-like 1

increases expression

Diclofenac results in increased expression of FGL1 mRNA

NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093

G

fibromodulin

decreases expression

Diclofenac results in decreased expression of FMOD mRNA

NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133

G

fibronectin 1

increases expression

Diclofenac results in increased expression of FN1 mRNA; Diclofenac results in increased expression of FN1 protein

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

formin binding protein 1

affects expression

Diclofenac affects the expression of FNBP1 mRNA

NCBI chr 3:14,309,067...14,424,378
Ensembl chr 3:14,309,640...14,424,881

G

fibronectin type III domain containing 3B

increases expression

Diclofenac results in increased expression of FNDC3B mRNA

NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830

G

folliculin interacting protein 1

decreases expression

Diclofenac results in decreased expression of FNIP1 mRNA

NCBI chr10:38,567,728...38,650,824
Ensembl chr10:38,567,729...38,650,824

G

folliculin interacting protein 2

decreases expression

Diclofenac results in decreased expression of FNIP2 mRNA

NCBI chr 2:164,596,557...164,708,147
Ensembl chr 2:164,598,906...164,707,901

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions
affects expression

Diclofenac results in increased expression of FOS mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FOS mRNA
Diclofenac affects the expression of FOS mRNA

PMID:12730611 PMID:24752500 PMID:37844793

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 2, AP-1 transcription factor subunit

increases expression

Diclofenac results in increased expression of FOSL2 mRNA

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

G

forkhead box A1

affects expression

Diclofenac affects the expression of FOXA1 mRNA

NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188

G

forkhead box A3

increases expression

Diclofenac results in increased expression of FOXA3 mRNA

NCBI chr 1:78,662,067...78,672,321
Ensembl chr 1:78,662,431...78,672,155

G

forkhead box O1

affects expression

Diclofenac affects the expression of FOXO1 mRNA

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box O3

affects expression
decreases expression

Diclofenac affects the expression of FOXO3 mRNA
Diclofenac results in decreased expression of FOXO3 mRNA

PMID:24752500 PMID:26934552

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

formyl peptide receptor 2

increases expression

Diclofenac results in increased expression of FPR2 mRNA

NCBI chr 1:58,776,592...58,785,227
Ensembl chr 1:58,776,752...58,786,019

G

FRAT regulator of WNT signaling pathway 2

decreases expression

Diclofenac results in decreased expression of FRAT2 mRNA

NCBI chr 1:240,654,120...240,656,449
Ensembl chr 1:240,654,137...240,656,517

G

fibroblast growth factor receptor substrate 2

affects expression

Diclofenac affects the expression of FRS2 mRNA

NCBI chr 7:52,711,255...52,792,738
Ensembl chr 7:52,711,257...52,792,743

G

formimidoyltransferase cyclodeaminase

affects expression

Diclofenac affects the expression of FTCD mRNA

NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735

G

FYN binding protein 1

increases expression

Diclofenac results in increased expression of FYB1 mRNA

NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629

G

frizzled class receptor 3

affects expression

Diclofenac affects the expression of FZD3 mRNA

NCBI chr15:39,421,366...39,488,369
Ensembl chr15:39,421,355...39,488,369

G

frizzled class receptor 4

affects expression

Diclofenac affects the expression of FZD4 mRNA

NCBI chr 1:143,279,934...143,288,799
Ensembl chr 1:143,280,065...143,285,724

G

frizzled class receptor 5

affects expression

Diclofenac affects the expression of FZD5 mRNA

NCBI chr 9:66,113,096...66,120,276
Ensembl chr 9:66,113,112...66,121,457

G

frizzled class receptor 6

affects expression

Diclofenac affects the expression of FZD6 mRNA

NCBI chr 7:70,055,012...70,086,781
Ensembl chr 7:70,055,068...70,086,776

G

frizzled class receptor 7

affects expression

Diclofenac affects the expression of FZD7 mRNA

NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781

G

GRB2-associated binding protein 1

affects expression

Diclofenac affects the expression of GAB1 mRNA

NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236

G

GRB2-associated binding protein 2

affects expression

Diclofenac affects the expression of GAB2 mRNA

NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031

G

gamma-aminobutyric acid type A receptor subunit alpha 5

decreases expression

Diclofenac results in decreased expression of GABRA5 mRNA

NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917

G

growth arrest and DNA-damage-inducible, alpha

increases expression
decreases expression
affects expression

Diclofenac results in increased expression of GADD45A mRNA
Diclofenac results in decreased expression of GADD45A mRNA
Diclofenac affects the expression of GADD45A mRNA

PMID:18172885 PMID:19022234 PMID:24752500 PMID:26934552 PMID:35537566

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

growth arrest and DNA-damage-inducible, gamma

increases expression

Diclofenac results in increased expression of GADD45G mRNA

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

polypeptide N-acetylgalactosaminyltransferase 3

increases expression

Diclofenac results in increased expression of GALNT3 mRNA

NCBI chr 3:50,742,500...50,779,266
Ensembl chr 3:50,742,512...50,766,268

G

glycyl-tRNA synthetase 1

affects expression
decreases expression

Diclofenac affects the expression of GARS1 mRNA
Diclofenac results in decreased expression of GARS1 mRNA

PMID:24752500 PMID:35537566

NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609

G

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

affects expression

Diclofenac affects the expression of GART mRNA

NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125

G

growth arrest-specific 1

decreases expression

Diclofenac results in decreased expression of GAS1 mRNA

NCBI chr17:4,482,168...4,485,153

G

GATA binding protein 4

affects expression

Diclofenac affects the expression of GATA4 mRNA

NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636

G

GATA binding protein 6

increases expression

Diclofenac results in increased expression of GATA6 mRNA

NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532

G

guanylate binding protein 1

decreases expression

Diclofenac results in decreased expression of GBP1 mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

guanylate binding protein 4

increases expression

Diclofenac results in increased expression of GBP3 mRNA

NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879

G

GC, vitamin D binding protein

multiple interactions

[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GC protein

NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567

G

glucokinase

affects expression

Diclofenac affects the expression of GCK mRNA

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

glutamate-cysteine ligase, catalytic subunit

decreases expression
affects expression
affects response to substance

Diclofenac results in decreased expression of GCLC mRNA
Diclofenac affects the expression of GCLC mRNA
GCLC protein affects the susceptibility to Diclofenac

PMID:17202759 PMID:19481141 PMID:24752500

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

affects expression

Diclofenac affects the expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

growth differentiation factor 15

increases expression

Diclofenac results in increased expression of GDF15 mRNA
Diclofenac results in increased expression of GDF15 protein

PMID:15555568 PMID:18076062

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

growth differentiation factor 6

increases expression

Diclofenac results in increased expression of GDF6 mRNA

NCBI chr 5:22,996,246...23,012,567
Ensembl chr 5:22,996,246...23,012,567

G

growth differentiation factor 9

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of GDF9 mRNA

NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672

G

glutamine fructose-6-phosphate transaminase 1

increases expression

Diclofenac results in increased expression of GFPT1 mRNA

NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471

G

gamma-glutamyltransferase 1

multiple interactions

[lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GGT1 protein

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

growth hormone receptor

affects expression

Diclofenac affects the expression of GHR protein

NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735

G

GIT ArfGAP 2

affects expression

Diclofenac affects the expression of GIT2 mRNA

NCBI chr12:41,829,717...41,872,621
Ensembl chr12:41,829,730...41,871,097

G

gap junction protein, alpha 1

increases expression

Diclofenac results in increased expression of GJA1 mRNA

PMID:26934552 PMID:35537566

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, alpha 3

increases expression

Diclofenac results in increased expression of GJA3 mRNA

NCBI chr15:31,181,360...31,206,820
Ensembl chr15:31,181,369...31,206,810

G

glycine decarboxylase

affects expression

Diclofenac affects the expression of GLDC mRNA

NCBI chr 1:227,883,249...227,962,119
Ensembl chr 1:227,883,249...227,962,097

G

glycerate kinase

affects expression

Diclofenac affects the expression of GLYCTK mRNA

NCBI chr 8:106,795,461...106,802,675
Ensembl chr 8:106,797,343...106,802,397

G

G protein subunit alpha 13

affects expression

Diclofenac affects the expression of GNA13 mRNA

NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774

G

G protein subunit alpha q

affects expression

Diclofenac affects the expression of GNAQ mRNA

NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672

G

GNAS complex locus

affects expression

Diclofenac affects the expression of GNAS mRNA

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

G protein subunit alpha transducin 1

increases expression

Diclofenac results in increased expression of GNAT1 mRNA

NCBI chr 8:108,350,935...108,355,671
Ensembl chr 8:108,350,935...108,355,671

G

G protein subunit beta 5

affects expression

Diclofenac affects the expression of GNB5 mRNA

NCBI chr 8:76,076,120...76,105,069
Ensembl chr 8:76,073,306...76,105,069

G

G protein subunit gamma 4

affects expression

Diclofenac affects the expression of GNG4 mRNA

NCBI chr17:86,448,708...86,497,560
Ensembl chr17:86,449,022...86,495,254

G

glutamic-oxaloacetic transaminase 1

affects expression
increases secretion

Diclofenac affects the expression of GOT1 mRNA
Diclofenac results in increased secretion of GOT1 protein

PMID:24752500 PMID:36442613

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glycerol-3-phosphate dehydrogenase 1

multiple interactions

Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of GPD1 protein]

NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529

G

glycosylphosphatidylinositol specific phospholipase D1

affects expression

Diclofenac affects the expression of GPLD1 mRNA

NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939

G

G protein-coupled receptor 176

decreases expression

Diclofenac results in decreased expression of GPR176 mRNA

NCBI chr 3:105,236,794...105,337,664
Ensembl chr 3:105,236,795...105,337,226

G

G protein-coupled receptor 20

decreases expression

Diclofenac results in decreased expression of GPR20 mRNA

NCBI chr 7:105,601,761...105,611,959
Ensembl chr 7:105,602,368...105,603,430

G

glutamic--pyruvic transaminase

multiple interactions
increases secretion
increases expression
increases activity

[lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GPT protein; Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]; Heparin inhibits the reaction [Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]]
Diclofenac results in increased secretion of GPT protein
Diclofenac results in increased expression of GPT protein
Diclofenac results in increased activity of GPT protein
eritoran inhibits the reaction [Diclofenac results in increased expression of GPT protein]

PMID:23939143 PMID:24747151 PMID:26934552 PMID:27671914 PMID:30925002 More...

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutamic--pyruvic transaminase 2

decreases expression

Diclofenac results in decreased expression of GPT2 mRNA

NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610

G

glutathione peroxidase 1

increases expression

Diclofenac results in increased expression of GPX1 mRNA; Diclofenac results in increased expression of GPX1 protein

PMID:25772430 PMID:29027214

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

affects expression

Diclofenac affects the expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

growth factor receptor bound protein 10

affects expression

Diclofenac affects the expression of GRB10 mRNA

NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806

G

glutamate ionotropic receptor delta type subunit 2

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of GRID2 mRNA

NCBI chr 4:92,415,019...93,892,472
Ensembl chr 4:92,415,230...93,889,355

G

glutamate metabotropic receptor 7

increases expression

Diclofenac results in increased expression of GRM7 mRNA

NCBI chr 4:143,730,862...144,613,230
Ensembl chr 4:143,731,259...144,612,344

G

gasdermin D

increases cleavage
multiple interactions

Diclofenac results in increased cleavage of GSDMD protein
diacerein inhibits the reaction [Diclofenac results in increased cleavage of GSDMD protein]

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

glycogen synthase kinase 3 beta

affects expression

Diclofenac affects the expression of GSK3B mRNA

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

gelsolin

decreases expression

Diclofenac results in decreased expression of GSN mRNA

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

glutathione S-transferase alpha 1

decreases activity

Diclofenac results in decreased activity of GSTA1 protein

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 4

decreases activity

Diclofenac results in decreased activity of GSTA4 protein

NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182

G

glutathione S-transferase alpha 5

multiple interactions
increases expression

[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GSTA5 protein
Diclofenac results in increased expression of GSTA5 protein

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase mu 1

decreases activity
decreases expression

Diclofenac results in decreased activity of GSTM1 protein
Diclofenac results in decreased expression of GSTM1 mRNA

PMID:26934552 PMID:27183920

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

decreases activity

Diclofenac results in decreased activity of GSTM2 protein

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase mu 4

affects activity

Diclofenac affects the activity of GSTM4 protein

NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323

G

glutathione S-transferase, mu 5

increases expression

Diclofenac results in increased expression of GSTM3 mRNA

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

glutathione S-transferase pi 1

multiple interactions
affects activity
affects metabolic processing

[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac
Diclofenac affects the activity of GSTP1 protein
GSTP1 protein affects the metabolism of Diclofenac metabolite; GSTP1 protein polymorphism affects the metabolism of Diclofenac metabolite

PMID:24185126 PMID:24246759 PMID:27183920

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

affects expression
affects activity

Diclofenac affects the expression of GSTT1 mRNA
Diclofenac affects the activity of GSTT1 protein

PMID:24752500 PMID:27183920

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

general transcription factor 2H subunit 4

affects expression

Diclofenac affects the expression of GTF2H4 mRNA

NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984

G

general transcription factor IIH subunit 5

affects expression

Diclofenac affects the expression of GTF2H5 mRNA

NCBI chr 1:46,656,804...46,663,512
Ensembl chr 1:46,656,859...46,664,939

G

GTP binding protein 2

decreases expression

Diclofenac results in decreased expression of GTPBP2 mRNA

NCBI chr 9:14,813,964...14,823,419
Ensembl chr 9:14,813,964...14,823,241

G

H2A.X variant histone

increases expression

Diclofenac results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

hepcidin antimicrobial peptide

affects expression
decreases secretion

Diclofenac affects the expression of HAMP mRNA
Diclofenac results in decreased secretion of HAMP protein

PMID:24038040 PMID:26934552

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

histone acetyltransferase 1

affects expression

Diclofenac affects the expression of HAT1 mRNA

NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517

G

hepatitis A virus cellular receptor 1

increases expression
multiple interactions
increases secretion

Diclofenac results in increased expression of HAVCR1 mRNA
diacerein inhibits the reaction [Diclofenac results in increased secretion of HAVCR1 protein]

PMID:23506792 PMID:38582345

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

hemoglobin alpha, adult chain 2

increases expression

Diclofenac results in increased expression of HBA-A2 protein

NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392

G

hemoglobin subunit beta

increases expression

Diclofenac results in increased expression of HBB protein

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

heparin-binding EGF-like growth factor

affects expression
decreases expression
increases expression

Diclofenac affects the expression of HBEGF mRNA
Diclofenac results in decreased expression of HBEGF mRNA
Diclofenac results in increased expression of HBEGF mRNA

PMID:24752500 PMID:26934552 PMID:35537566

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

HCK proto-oncogene, Src family tyrosine kinase

increases expression

Diclofenac results in increased expression of HCK mRNA

NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

decreases expression
increases expression

Diclofenac results in decreased expression of HERC6 mRNA
Diclofenac results in increased expression of HERC6 mRNA

PMID:19192274 PMID:26934552

NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744

G

homocysteine inducible ER protein with ubiquitin like domain 1

affects expression
decreases expression

Diclofenac affects the expression of HERPUD1 mRNA
Diclofenac results in decreased expression of HERPUD1 mRNA

PMID:24752500 PMID:26934552 PMID:35537566

NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424

G

hes family bHLH transcription factor 6

decreases expression

Diclofenac results in decreased expression of HES6 mRNA

NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559

G

hematopoietically expressed homeobox

decreases expression

Diclofenac results in decreased expression of HHEX mRNA

NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042

G

hypoxia inducible factor 1 subunit alpha

decreases expression

Diclofenac results in decreased expression of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

histone cluster 2 H2B family member E

decreases expression

Diclofenac results in decreased expression of H2BC21 mRNA

NCBI chr 2:183,780,583...183,783,030

G

hexokinase 1

increases expression

Diclofenac results in increased expression of HK1 mRNA

NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131

G

high mobility group box 1

multiple interactions
increases expression
affects expression

Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMGB1 protein]
Diclofenac results in increased expression of HMGB1 mRNA; Diclofenac results in increased expression of HMGB1 protein
Diclofenac affects the expression of HMGB1 mRNA

PMID:23939143 PMID:24747151 PMID:24752500 PMID:26934552

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

decreases expression

Diclofenac results in decreased expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

heme oxygenase 1

multiple interactions
decreases expression
increases expression
affects expression

1-aminobenzotriazole inhibits the reaction [[Diclofenac co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Diclofenac results in decreased expression of HMOX1 protein
Diclofenac results in increased expression of HMOX1 mRNA; Diclofenac results in increased expression of HMOX1 protein
Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 protein]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of HMOX1 protein]
Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; diacerein inhibits the reaction [Diclofenac results in decreased expression of HMOX1 protein]; Diclofenac promotes the reaction [Poly I-C results in increased expression of HMOX1 mRNA]; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Sulfaphenazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Tranylcypromine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Diclofenac affects the expression of HMOX1 protein

PMID:12763371 PMID:18172885 PMID:18227147 PMID:19022234 PMID:19952508 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

H6 family homeobox 3

decreases expression

Diclofenac results in decreased expression of HMX3 mRNA

NCBI chr 1:186,313,237...186,315,201
Ensembl chr 1:186,313,063...186,315,201

G

HNF1 homeobox A

affects expression

Diclofenac affects the expression of HNF1A mRNA

NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104

G

hepatocyte nuclear factor 4, alpha

decreases expression

Diclofenac results in decreased expression of HNF4A mRNA

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

heterogeneous nuclear ribonucleoprotein D

affects expression

Diclofenac affects the expression of HNRNPD mRNA

NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786

G

HOATZ cilia and flagella associated protein

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of HOATZ mRNA

NCBI chr 8:51,385,931...51,409,796
Ensembl chr 8:51,388,382...51,412,514

G

haptoglobin

decreases expression
increases expression

Diclofenac results in decreased expression of HP mRNA
Diclofenac results in increased expression of HP mRNA

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

15-hydroxyprostaglandin dehydrogenase

increases activity
multiple interactions
increases expression

Diclofenac results in increased activity of HPGD protein
[Diclofenac co-treated with NAD] binds to HPGD protein
Diclofenac results in increased expression of HPGD mRNA

PMID:19501039 PMID:25526675

NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228

G

HRas proto-oncogene, GTPase

affects expression

Diclofenac affects the expression of HRAS mRNA

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

heparan sulfate-glucosamine 3-sulfotransferase 3B1

decreases expression

Diclofenac results in decreased expression of HS3ST3B1 mRNA

NCBI chr10:48,561,473...48,593,970
Ensembl chr10:48,561,473...48,593,970

G

heparan sulfate 6-O-sulfotransferase 2

increases expression

Diclofenac results in increased expression of HS6ST2 mRNA

NCBI chr X:130,966,547...131,261,629
Ensembl chr X:130,968,385...131,261,492

G

heat shock transcription factor 1

increases activity

Diclofenac results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein 90 alpha family class A member 1

multiple interactions

Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSP90AA1 mRNA]

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein family A (Hsp70) member 1A

multiple interactions
increases expression
affects expression

Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA1A mRNA]
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of HSPA1A mRNA
Diclofenac results in increased expression of HSPA1A mRNA
Diclofenac affects the expression of HSPA1A mRNA

PMID:19022234 PMID:23939143 PMID:25014874 PMID:26934552 PMID:37844793

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

increases expression
multiple interactions

Diclofenac results in increased expression of HSPA1B mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of HSPA1B mRNA

PMID:26934552 PMID:37844793

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

Diclofenac results in increased expression of HSPA5 mRNA
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HSPA5 protein

PMID:25014874 PMID:25772430 PMID:27313093

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

multiple interactions
increases expression

Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA8 mRNA]
Diclofenac results in increased expression of HSPA8 mRNA

PMID:23939143 PMID:26934552

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family B (small) member 1

decreases expression

Diclofenac results in decreased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family B (small) member 8

increases expression

Diclofenac results in increased expression of HSPB8 mRNA

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

G

isoleucyl-tRNA synthetase 1

decreases expression

Diclofenac results in decreased expression of IARS1 mRNA

NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237

G

inhibitor of Bruton tyrosine kinase

increases expression

Diclofenac results in increased expression of IBTK mRNA

NCBI chr 8:86,625,591...86,698,661
Ensembl chr 8:86,625,597...86,698,260

G

intercellular adhesion molecule 1

multiple interactions
decreases expression
increases expression
affects expression

Amlodipine inhibits the reaction [Diclofenac results in decreased expression of ICAM1 protein]
Diclofenac results in decreased expression of ICAM1 mRNA
Diclofenac results in increased expression of ICAM1 mRNA
Diclofenac affects the expression of ICAM1 mRNA

PMID:14716214 PMID:18460984 PMID:24752500 PMID:26934552

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 2

increases expression

Diclofenac results in increased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

inhibitor of DNA binding 3

increases expression

Diclofenac results in increased expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

isocitrate dehydrogenase (NADP(+)) 2

decreases expression

Diclofenac results in decreased expression of IDH2 mRNA

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

immediate early response 3

increases expression

Diclofenac results in increased expression of IER3 mRNA

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

interferon, alpha-inducible protein 27

decreases expression

Diclofenac results in decreased expression of IFI27 mRNA

NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294

G

interferon-induced protein 35

decreases expression

Diclofenac results in decreased expression of IFI35 mRNA

NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952

G

interferon-induced protein 44

decreases expression

Diclofenac results in decreased expression of IFI44 mRNA

PMID:19192274 PMID:35537566

NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844

G

interferon-induced protein 44-like

decreases expression

Diclofenac results in decreased expression of IFI44L mRNA

NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359

G

interferon induced with helicase C domain 1

decreases expression

Diclofenac results in decreased expression of IFIH1 mRNA

NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456

G

interferon-induced protein with tetratricopeptide repeats 3

decreases expression

Diclofenac results in decreased expression of IFIT3 mRNA

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interferon induced transmembrane protein 2

increases expression

Diclofenac results in increased expression of IFITM2 mRNA

NCBI chr 1:196,051,539...196,052,719
Ensembl chr 1:196,051,537...196,052,741

G

interferon induced transmembrane protein 3

increases expression

Diclofenac results in increased expression of IFITM3 mRNA

NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203

G

interferon gamma

multiple interactions
decreases expression

3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac affects the abundance of Calcium]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Calcium promotes the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]
Diclofenac results in decreased expression of IFNG mRNA

PMID:19393675 PMID:22285467 PMID:23395999 PMID:23939143 PMID:26609140

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

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interferon-related developmental regulator 1

decreases expression

Diclofenac results in decreased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

insulin-like growth factor 1 receptor

affects expression

Diclofenac affects the expression of IGF1R mRNA

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor 2 receptor

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of IGF2R mRNA

NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501

G

insulin-like growth factor binding protein 1

affects expression
increases expression

Diclofenac affects the expression of IGFBP1 mRNA
Diclofenac results in increased expression of IGFBP1 mRNA

PMID:24752500 PMID:26934552

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

insulin-like growth factor binding protein 2

decreases expression

Diclofenac results in decreased expression of IGFBP2 mRNA

NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937

G

insulin-like growth factor binding protein 3

affects expression

Diclofenac affects the expression of IGFBP3 mRNA

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

inhibitor of nuclear factor kappa B kinase subunit epsilon

increases expression

Diclofenac results in increased expression of IKBKE mRNA

NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

affects expression

Diclofenac affects the expression of IKBKG mRNA

NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499

G

interleukin 10

increases response to substance
multiple interactions

IL10 gene polymorphism results in increased susceptibility to Diclofenac
[Gum Arabic co-treated with Water deficiency co-treated with Diclofenac] results in increased expression of IL10 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL10 protein]

PMID:15122773 PMID:23939143 PMID:31042592

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12 receptor subunit beta 1

increases expression

Diclofenac results in increased expression of IL12RB1 mRNA

NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769

G

interleukin 13 receptor subunit alpha 1

increases expression

Diclofenac results in increased expression of IL13RA1 mRNA

NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681

G

interleukin 16

decreases expression

Diclofenac results in decreased expression of IL16 mRNA

NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130

G

interleukin 17A

increases expression
multiple interactions

Diclofenac results in increased expression of IL17A protein
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]

PMID:22285467 PMID:25450234

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

multiple interactions
increases expression

diacerein inhibits the reaction [Diclofenac results in increased expression of IL18 protein]

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 18 binding protein

increases expression

Diclofenac results in increased expression of IL18BP mRNA

NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963

G

interleukin 1 alpha

multiple interactions
increases expression

[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac
Diclofenac results in increased expression of IL1A mRNA

PMID:19362101 PMID:32816093

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases expression

Diclofenac inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]
Diclofenac results in increased expression of IL1B mRNA
Diclofenac results in increased expression of IL1B mRNA; Diclofenac results in increased expression of IL1B protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; [Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; diacerein inhibits the reaction [Diclofenac results in increased expression of IL1B protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]

PMID:15135310 PMID:15705740 PMID:19393675 PMID:22285467 PMID:23395999 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

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interleukin 1 receptor type 1

affects expression
increases expression

Diclofenac affects the expression of IL1R1 mRNA
Diclofenac results in increased expression of IL1R1 mRNA

PMID:24752500 PMID:26934552

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 1 receptor type 2

increases expression

Diclofenac results in increased expression of IL1R2 mRNA

PMID:26934552 PMID:30723492

NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725

G

interleukin 1 receptor antagonist

increases expression
decreases expression
increases secretion
multiple interactions

Diclofenac results in increased expression of IL1RN mRNA
Diclofenac results in decreased expression of IL1RN mRNA
Diclofenac results in increased secretion of IL1RN protein
Lipopolysaccharides inhibits the reaction [Diclofenac results in increased secretion of IL1RN protein]

PMID:9491209 PMID:26934552 PMID:35537566

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2

multiple interactions

Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein]

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 23 subunit alpha

decreases expression

Diclofenac results in decreased expression of IL23A mRNA

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

G

interleukin 24

increases expression

Diclofenac results in increased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

interleukin 2 receptor subunit gamma

increases expression

Diclofenac results in increased expression of IL2RG mRNA

NCBI chr X:66,395,330...66,399,026
Ensembl chr X:66,392,542...66,399,823

G

interleukin 33

increases expression
decreases expression

Diclofenac results in increased expression of IL33 mRNA
Diclofenac results in decreased expression of IL33 mRNA

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

G

interleukin 4

increases response to substance

IL4 gene polymorphism results in increased susceptibility to Diclofenac

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

multiple interactions

Diclofenac inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein]

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

multiple interactions
increases expression
decreases expression

[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac; Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein]; Diclofenac inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]; lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Diclofenac results in increased expression of IL6 protein]
Diclofenac results in increased expression of IL6 mRNA
Diclofenac results in decreased expression of IL6 mRNA; Diclofenac results in decreased expression of IL6 protein
Diclofenac results in increased expression of IL6 mRNA; Diclofenac results in increased expression of IL6 protein
Diclofenac inhibits the reaction [Carrageenan results in increased expression of IL6 protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]

PMID:19192274 PMID:19362101 PMID:23506792 PMID:23939143 PMID:24412305 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inner membrane mitochondrial protein

affects expression

Diclofenac affects the expression of IMMT mRNA

NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109

G

inhibin subunit beta B

increases expression

Diclofenac results in increased expression of INHBB mRNA

PMID:26934552 PMID:30723492

NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832

G

inka box actin regulator 2

increases expression

Diclofenac results in increased expression of FAM212B mRNA

NCBI chr 2:193,185,275...193,200,643
Ensembl chr 2:193,185,275...193,200,642

G

indolethylamine N-methyltransferase

decreases expression

Diclofenac results in decreased expression of INMT mRNA

NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493

G

insulin-like 3

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of INSL3 mRNA

NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560

G

insulin-like 6

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of INSL6 mRNA

NCBI chr 1:227,069,958...227,073,493
Ensembl chr 1:227,069,958...227,073,493

G

insulin receptor

affects expression

Diclofenac affects the expression of INSR mRNA

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

IQ motif containing F1

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of IQCF1 mRNA

NCBI chr 8:107,129,462...107,133,242
Ensembl chr 8:107,130,704...107,133,249

G

interleukin-1 receptor-associated kinase 4

increases expression

Diclofenac results in increased expression of IRAK4 mRNA

NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837

G

interferon regulatory factor 7

decreases expression

Diclofenac results in decreased expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

immunity-related GTPase M

increases expression

Diclofenac results in increased expression of IRGM1 mRNA

NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578

G

insulin receptor substrate 1

affects expression

Diclofenac affects the expression of IRS1 mRNA

PMID:24752500 PMID:26934552

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

ISG15 ubiquitin-like modifier

decreases expression

Diclofenac results in decreased expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

interferon stimulated exonuclease gene 20

decreases expression

Diclofenac results in decreased expression of ISG20 mRNA

NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027

G

inositol-3-phosphate synthase 1

increases expression

Diclofenac results in increased expression of ISYNA1 mRNA

NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979

G

integrin subunit alpha 2

affects expression

Diclofenac affects the expression of ITGA2 mRNA

NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481

G

integrin subunit alpha L

increases expression

Diclofenac results in increased expression of ITGAL mRNA

NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732

G

integrin subunit alpha M

increases expression

Diclofenac results in increased expression of ITGAM mRNA

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit alpha X

decreases expression

Diclofenac results in decreased expression of ITGAX mRNA

NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698

G

integrin subunit beta 1

affects expression

Diclofenac affects the expression of ITGB1 mRNA

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

integrin subunit beta 2

increases expression

Diclofenac results in increased expression of ITGB2 mRNA

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

integrin subunit beta 3

multiple interactions

Diclofenac inhibits the reaction [TNF protein results in increased expression of ITGB3 protein]

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

inter-alpha trypsin inhibitor, heavy chain 3

increases expression

Diclofenac results in increased expression of ITIH3 mRNA

NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924

G

inter-alpha-trypsin inhibitor heavy chain 4

increases expression

Diclofenac results in increased expression of ITIH4 mRNA

NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708

G

integral membrane protein 2A

increases expression

Diclofenac results in increased expression of ITM2A mRNA

NCBI chr X:72,486,383...72,492,344
Ensembl chr X:72,486,381...72,492,363

G

jade family PHD finger 2

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of JADE2 mRNA

NCBI chr10:36,075,239...36,124,210
Ensembl chr10:36,078,917...36,116,984

G

jade family PHD finger 3

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of JADE3 mRNA

NCBI chr X:1,668,873...1,848,781
Ensembl chr X:1,669,930...1,845,138

G

Jun dimerization protein 2

decreases expression

Diclofenac results in decreased expression of JDP2 mRNA

NCBI chr 6:105,261,619...105,302,386
Ensembl chr 6:105,261,373...105,301,485

G

Jun proto-oncogene, AP-1 transcription factor subunit

affects expression
increases expression

Diclofenac affects the expression of JUN mRNA
Diclofenac results in increased expression of JUN mRNA

PMID:24752500 PMID:26934552

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

JunD proto-oncogene, AP-1 transcription factor subunit

increases expression

Diclofenac results in increased expression of JUND mRNA

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

lysine acetyltransferase 6B

affects expression

Diclofenac affects the expression of KAT6B mRNA

NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316

G

kelch repeat and BTB domain containing 11

increases expression

Diclofenac results in increased expression of KBTBD11 mRNA

NCBI chr16:74,618,291...74,638,010
Ensembl chr16:74,615,792...74,637,736

G

KH domain containing 3, subcortical maternal complex member

increases expression

Diclofenac results in increased expression of KHDC3 mRNA

NCBI chr 8:73,842,344...73,844,248
Ensembl chr 8:73,842,344...73,844,248

G

kinesin family member 5C

increases expression

Diclofenac results in increased expression of KIF5C mRNA

NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413

G

KIT proto-oncogene receptor tyrosine kinase

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of KIT mRNA

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

KLF transcription factor 4

decreases expression

Diclofenac results in decreased expression of KLF4 mRNA

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

kelch-like family member 33

decreases expression

Diclofenac results in decreased expression of KLHL33 mRNA

NCBI chr15:24,105,923...24,114,445
Ensembl chr15:24,105,930...24,114,438

G

kallikrein 1

increases expression

Diclofenac results in increased expression of KLK1 protein

NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754

G

kinase non-catalytic C-lobe domain containing 1

increases expression

Diclofenac results in increased expression of KNDC1 mRNA

NCBI chr 1:194,689,962...194,738,353
Ensembl chr 1:194,690,135...194,738,362

G

kininogen 1

increases expression
multiple interactions

Diclofenac results in increased expression of KNG1 protein
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of KNG1 protein; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in increased expression of KNG1 protein]

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

KRAS proto-oncogene, GTPase

affects expression

Diclofenac affects the expression of KRAS mRNA

NCBI chr 4:178,185,418...178,218,484

G

lymphocyte transmembrane adaptor 1

decreases expression

Diclofenac results in decreased expression of LAX1 mRNA

NCBI chr13:45,134,825...45,145,381
Ensembl chr13:45,134,834...45,145,381

G

lipopolysaccharide binding protein

increases expression
decreases expression
affects expression

Diclofenac results in increased expression of LBP protein
Diclofenac results in decreased expression of LBP mRNA
Diclofenac affects the expression of LBP mRNA

NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586

G

lipocalin 2

increases expression
increases secretion
multiple interactions

Diclofenac results in increased expression of LCN2 mRNA
Diclofenac results in increased secretion of LCN2 protein
diacerein inhibits the reaction [Diclofenac results in increased secretion of LCN2 protein]; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of LCN2 mRNA]

PMID:23939143 PMID:26934552 PMID:38582345

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

lymphocyte cytosolic protein 2

increases expression

Diclofenac results in increased expression of LCP2 mRNA

NCBI chr10:18,642,600...18,689,562
Ensembl chr10:18,642,658...18,689,559

G

lactate dehydrogenase A

increases expression

Diclofenac results in increased expression of LDHA protein

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

liver enriched antimicrobial peptide 2

increases expression

Diclofenac results in increased expression of LEAP2 mRNA

NCBI chr10:37,580,172...37,581,244
Ensembl chr10:37,577,855...37,581,244

G

leptin receptor

affects expression
increases expression

Diclofenac affects the expression of LEPR mRNA
Diclofenac results in increased expression of LEPR protein

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

galectin 3

increases expression

Diclofenac results in increased expression of LGALS3 mRNA

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

G

legumain

increases expression

Diclofenac results in increased expression of LGMN mRNA

NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480

G

leucine-rich repeat-containing G protein-coupled receptor 4

increases expression

Diclofenac results in increased expression of LGR4 mRNA

NCBI chr 3:96,447,385...96,550,006
Ensembl chr 3:96,447,858...96,548,899

G

LIM homeobox 2

decreases expression

Diclofenac results in decreased expression of LHX2 mRNA

NCBI chr 3:22,113,619...22,143,909
Ensembl chr 3:22,126,007...22,143,908

G

LIF receptor subunit alpha

decreases expression

Diclofenac results in decreased expression of LIFR mRNA

NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699

G

lipase C, hepatic type

decreases expression

Diclofenac results in decreased expression of LIPC mRNA

NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464

G

lipopolysaccharide-induced TNF factor

increases expression

Diclofenac results in increased expression of LITAF mRNA

NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763

G

lamin B1

increases expression

Diclofenac results in increased expression of LMNB1 mRNA

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

LIM domain only 4

decreases expression

Diclofenac results in decreased expression of LMO4 mRNA

NCBI chr 2:233,264,180...233,280,881
Ensembl chr 2:233,264,182...233,280,880

G

lysophosphatidic acid receptor 4

decreases expression

Diclofenac results in decreased expression of LPAR4 mRNA

NCBI chr X:72,033,486...72,046,978
Ensembl chr X:72,033,486...72,046,977

G

lipoprotein lipase

increases expression

Diclofenac results in increased expression of LPL mRNA

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

leucine-rich alpha-2-glycoprotein 1

increases expression

Diclofenac results in increased expression of LRG1 mRNA

NCBI chr 9:947,516...949,773
Ensembl chr 9:947,516...949,813

G

LDL receptor related protein 8

increases expression

Diclofenac results in increased expression of LRP8 mRNA

NCBI chr 5:122,563,468...122,635,434
Ensembl chr 5:122,563,453...122,631,352

G

leukotriene C4 synthase

increases expression

Diclofenac results in increased expression of LTC4S mRNA

NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651

G

latexin

increases expression

Diclofenac results in increased expression of LXN mRNA

NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:151,727,102...151,733,460

G

lymphocyte antigen 6 family member E

decreases expression
increases expression

Diclofenac results in decreased expression of LY6E mRNA
Diclofenac results in increased expression of LY6E mRNA

PMID:19192274 PMID:26934552

NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689

G

lymphocyte antigen 75

increases expression

Diclofenac results in increased expression of LY75 mRNA

NCBI chr 3:44,764,702...44,852,219
Ensembl chr 3:44,765,122...44,852,374

G

lysozyme 2

increases expression

Diclofenac results in increased expression of LYZ2 mRNA

NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106

G

membrane associated guanylate kinase, WW and PDZ domain containing 1

affects expression

Diclofenac affects the expression of MAGI1 mRNA

NCBI chr 4:126,205,663...126,811,354
Ensembl chr 4:126,206,816...126,811,691

G

mitochondrial assembly of ribosomal large subunit 1

multiple interactions

[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MALSU1 mRNA

NCBI chr 4:78,051,090...78,059,913
Ensembl chr 4:78,051,059...78,059,905

G

monoamine oxidase A

affects expression

Diclofenac affects the expression of MAOA mRNA

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

monoamine oxidase B

affects expression

Diclofenac affects the expression of MAOB mRNA

NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003

G

mitogen activated protein kinase kinase 3

affects expression

Diclofenac affects the expression of MAP2K3 mRNA

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

G

mitogen activated protein kinase kinase 5

affects expression

Diclofenac affects the expression of MAP2K5 mRNA

NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983