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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzimidazole fungicide
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Accession:CHEBI:87036 term browser browse the term
Definition:Compounds that contain a benzimidazole moiety as a key feature of their structure and which have been used as fungicides.
Synonyms:related_synonym: benzimidazole fungicides


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benomyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam33 ADAM metallopeptidase domain 33 multiple interactions
increases expression
ISO ORMDL3 protein affects the reaction [Benomyl results in increased expression of ADAM33 protein] CTD PMID:27784618 NCBI chr 3:123,595,018...123,607,549
Ensembl chr 3:123,595,560...123,607,352
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases activity ISO
EXP
Benomyl metabolite results in decreased activity of ALDH2 protein; Benomyl results in decreased activity of ALDH2 protein CTD PMID:9585485 PMID:10513990 PMID:11142365 PMID:15331769 PMID:17010440 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 decreases activity EXP Benomyl results in decreased activity of ALDH5A1 protein CTD PMID:17010440 NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 decreases expression EXP Benomyl results in decreased expression of AMPD3 mRNA CTD PMID:15885261 NCBI chr 1:175,585,301...175,630,479
Ensembl chr 1:175,586,097...175,630,467
JBrowse link
G Ar androgen receptor multiple interactions ISO Benomyl inhibits the reaction [Dihydrotestosterone affects the localization of and results in increased phosphorylation of AR protein] CTD PMID:25324206 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Benomyl inhibits the reaction [BCL2 protein binds to BAX protein] CTD PMID:16903866 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases phosphorylation
ISO Benomyl inhibits the reaction [BCL2 protein binds to BAX protein]
Benomyl results in increased phosphorylation of BCL2 protein
CTD PMID:16903866 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B increases expression ISO Benomyl results in increased expression of BUB1B protein CTD PMID:16903866 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G Car2 carbonic anhydrase 2 increases expression EXP Benomyl results in increased expression of CA2 mRNA CTD PMID:15885261 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 increases expression
multiple interactions
ISO Benomyl results in increased expression of CCL17 mRNA
ORMDL3 protein affects the reaction [Benomyl results in increased expression of CCL17 mRNA]
CTD PMID:27784618 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccnb1 cyclin B1 increases response to substance ISO CCNB1 protein results in increased susceptibility to Benomyl CTD PMID:11960377 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb2 cyclin B2 increases response to substance ISO CCNB2 protein results in increased susceptibility to Benomyl CTD PMID:11960377 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Cd38 CD38 molecule decreases expression EXP Benomyl results in decreased expression of CD38 mRNA CTD PMID:15885261 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression
multiple interactions
ISO Benomyl results in decreased expression of CYP17A1 mRNA
Benomyl results in decreased expression of and results in decreased activity of CYP17A1 protein
CTD PMID:25324206 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity
increases expression
ISO Benomyl results in increased activity of CYP19A1 protein
Benomyl results in increased expression of CYP19A1 mRNA
CTD PMID:14691014 PMID:25543211 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Benomyl results in increased expression of DDIT3 protein]; MitoTEMPO inhibits the reaction [Benomyl results in increased expression of DDIT3 protein] CTD PMID:27784618 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression
multiple interactions
ISO Benomyl results in increased expression of EIF2AK3 protein
Acetylcysteine inhibits the reaction [Benomyl results in increased expression of EIF2AK3 protein]; MitoTEMPO inhibits the reaction [Benomyl results in increased expression of EIF2AK3 protein]
CTD PMID:27784618 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Benomyl results in increased expression of ERN1 protein]; MitoTEMPO inhibits the reaction [Benomyl results in increased expression of ERN1 protein] CTD PMID:27784618 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding
ISO Benomyl binds to and results in increased activity of ESR1 protein; Benomyl inhibits the reaction [Estradiol binds to ESR1 protein]
Benomyl binds to ESR1 protein
CTD PMID:14579009 PMID:16626760 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 increases expression EXP Benomyl results in increased expression of FGFR4 mRNA CTD PMID:15885261 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321
JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 increases expression EXP Benomyl results in increased expression of GIPC1 mRNA CTD PMID:15885261 NCBI chr19:24,786,604...24,798,231
Ensembl chr19:24,786,628...24,798,233
JBrowse link
G Glyat glycine-N-acyltransferase increases expression EXP Benomyl results in increased expression of GLYAT mRNA CTD PMID:15885261 NCBI chr 1:229,060,125...229,081,113
Ensembl chr 1:229,063,714...229,080,410
JBrowse link
G Hdac1 histone deacetylase 1 decreases activity ISO Benomyl results in decreased activity of HDAC1 protein CTD PMID:25543211 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO Benomyl results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [Benomyl results in increased expression of HSPA5 protein]; MitoTEMPO inhibits the reaction [Benomyl results in increased expression of HSPA5 protein]
CTD PMID:27784618 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression EXP Benomyl results in increased expression of HSPB1 mRNA CTD PMID:15885261 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Benomyl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:18177342 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Itga5 integrin subunit alpha 5 decreases expression ISO Benomyl results in decreased expression of ITGA5 mRNA CTD PMID:25530041 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Benomyl results in decreased expression of ITGB1 mRNA CTD PMID:25530041 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
increases expression
ISO Benomyl results in decreased expression of MMP2 mRNA
ORMDL3 protein affects the reaction [Benomyl results in increased expression of MMP2 protein]
CTD PMID:25530041 PMID:27784618 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP
ISO
Benomyl results in decreased expression of MMP9 protein
Benomyl results in decreased expression of MMP9 mRNA
CTD PMID:10026946 PMID:25530041 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mmrn1 multimerin 1 increases expression EXP Benomyl results in increased expression of MMRN1 mRNA CTD PMID:15885261 NCBI chr 4:90,977,537...91,038,747
Ensembl chr 4:90,990,088...91,038,748
JBrowse link
G Msmb microseminoprotein, beta increases expression EXP Benomyl results in increased expression of MSMB mRNA CTD PMID:15885261 NCBI chr16:8,280,275...8,300,853
Ensembl chr16:8,280,275...8,300,852
JBrowse link
G Mt2A metallothionein 2A increases expression EXP Benomyl results in increased expression of MT2A mRNA CTD PMID:15885261 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Benomyl inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:17015962 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Benomyl inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Olr1346 olfactory receptor 1346 increases expression EXP Benomyl results in increased expression of OLR1346 mRNA CTD PMID:15885261 NCBI chr 9:99,720,856...99,721,827
Ensembl chr 9:99,720,856...99,721,827
JBrowse link
G Olr1700 olfactory receptor 1700 increases expression EXP Benomyl results in increased expression of OLR1700 mRNA CTD PMID:15885261 NCBI chr20:1,089,163...1,090,128
Ensembl chr20:1,098,343...1,099,336
JBrowse link
G Olr857 olfactory receptor 857 increases expression EXP Benomyl results in increased expression of OLR857 mRNA CTD PMID:15885261 NCBI chr 5:137,738,298...137,739,246
Ensembl chr 5:137,738,298...137,739,246
Ensembl chr 5:137,738,298...137,739,246
JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Benomyl results in increased expression of ORMDL3 protein]; MitoTEMPO inhibits the reaction [Benomyl results in increased expression of ORMDL3 protein]; ORMDL3 protein affects the reaction [Benomyl results in increased expression of ADAM33 protein]; ORMDL3 protein affects the reaction [Benomyl results in increased expression of CCL17 mRNA]; ORMDL3 protein affects the reaction [Benomyl results in increased expression of CXCL8 mRNA]; ORMDL3 protein affects the reaction [Benomyl results in increased expression of MMP2 protein]; ORMDL3 protein affects the reaction [Benomyl results in increased expression of TSLP mRNA] CTD PMID:27784618 NCBI chr10:86,545,910...86,554,478
Ensembl chr10:86,547,339...86,554,478
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Benomyl results in increased cleavage of PARP1 protein CTD PMID:16903866 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO Benomyl results in decreased expression of PLAU mRNA CTD PMID:25530041 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP Benomyl results in decreased expression of SCD1 mRNA CTD PMID:15885261 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpine2 serpin family E member 2 increases expression ISO Benomyl results in increased expression of SERPINE2 mRNA CTD PMID:25530041 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Sh2d4a SH2 domain containing 4A increases expression EXP Benomyl results in increased expression of SH2D4A mRNA CTD PMID:15885261 NCBI chr16:23,084,247...23,156,825
Ensembl chr16:23,083,954...23,156,962
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Benomyl results in increased expression of TIMP1 mRNA CTD PMID:25530041 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO Benomyl results in increased expression of TIMP2 mRNA CTD PMID:25530041 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tslp thymic stromal lymphopoietin increases expression
multiple interactions
ISO Benomyl results in increased expression of TSLP mRNA
ORMDL3 protein affects the reaction [Benomyl results in increased expression of TSLP mRNA]
CTD PMID:27784618 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO Benomyl results in increased activity of and results in increased ubiquitination of UBA1 protein CTD PMID:25714994 NCBI chr  X:1,723,135...1,745,147
Ensembl chr  X:1,723,174...1,741,701
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions EXP Benomyl inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]; Benomyl inhibits the reaction [Pentaerythritol Tetranitrate results in increased phosphorylation of VASP protein] CTD PMID:15331769 NCBI chr 1:80,170,608...80,185,882
Ensembl chr 1:80,170,619...80,185,882
JBrowse link
carbendazim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 increases expression EXP carbendazim results in increased expression of ABI2 mRNA CTD PMID:22952946 NCBI chr 9:67,234,612...67,284,504
Ensembl chr 9:67,234,303...67,282,600
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression ISO carbendazim results in increased expression of ACACA mRNA CTD PMID:26071454 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP [carbendazim co-treated with mancozeb] results in increased activity of ACHE protein CTD PMID:33217513 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 increases expression ISO carbendazim results in increased expression of AGPAT2 mRNA CTD PMID:26071454 NCBI chr 3:4,044,741...4,055,384
Ensembl chr 3:4,044,542...4,055,806
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization
ISO AHR protein affects the reaction [carbendazim results in increased expression of CYP1A1 protein]
carbendazim affects the localization of AHR protein
CTD PMID:27286660 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Anxa10 annexin A10 increases expression ISO carbendazim results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:29,674,699...29,741,521
Ensembl chr16:29,674,793...29,741,465
JBrowse link
G Arg1 arginase 1 decreases expression ISO carbendazim results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Bag1 BAG cochaperone 1 increases expression EXP carbendazim results in increased expression of BAG1 mRNA CTD PMID:22952946 NCBI chr 5:57,254,421...57,267,002
Ensembl chr 5:57,254,421...57,267,002
JBrowse link
G Bcl2l14 BCL2 like 14 increases expression EXP carbendazim results in increased expression of BCL2L14 mRNA CTD PMID:22952946 NCBI chr 4:168,139,964...168,183,726
Ensembl chr 4:168,142,271...168,183,096
JBrowse link
G Casp3 caspase 3 increases activity ISO carbendazim results in increased activity of CASP3 protein CTD PMID:30851412 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Clca2 chloride channel accessory 2 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of CLCA2 mRNA CTD PMID:22382377 NCBI chr 2:250,954,423...250,981,544
Ensembl chr 2:250,954,397...250,981,623
JBrowse link
G Cldn11 claudin 11 multiple interactions EXP [carbendazim co-treated with iprodione] results in decreased expression of CLDN11 protein CTD PMID:28576679 NCBI chr 2:115,823,541...115,836,846
Ensembl chr 2:115,823,538...115,836,846
JBrowse link
G Clu clusterin decreases expression
increases expression
EXP carbendazim results in decreased expression of CLU mRNA
carbendazim results in increased expression of CLU mRNA
CTD PMID:22952946 PMID:27466211 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity
increases expression
ISO carbendazim results in increased activity of CYP19A1 protein
carbendazim results in increased expression of CYP19A1 mRNA
CTD PMID:14691014 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO
EXP
carbendazim results in increased expression of CYP1A1 mRNA; carbendazim results in increased expression of CYP1A1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [carbendazim results in increased expression of CYP1A1 protein]; AHR protein affects the reaction [carbendazim results in increased expression of CYP1A1 protein]; salicylamide inhibits the reaction [carbendazim results in increased expression of CYP1A1 protein]
CTD PMID:10103034 PMID:21784029 PMID:27286660 PMID:32194361 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO carbendazim results in increased expression of CYP1A2 mRNA; carbendazim results in increased expression of CYP1A2 protein CTD PMID:21784029 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO carbendazim results in increased expression of CYP2B6 mRNA CTD PMID:22310298 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO carbendazim results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO carbendazim results in decreased activity of CYP2D6 protein CTD PMID:20183062 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression ISO carbendazim results in increased expression of CYP3A4 mRNA CTD PMID:22310298 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO carbendazim results in decreased expression of CYP7A1 mRNA; carbendazim results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 increases expression ISO carbendazim results in increased expression of DGAT1 mRNA CTD PMID:26071454 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 increases expression ISO carbendazim results in increased expression of DGAT2 mRNA CTD PMID:26071454 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Dnaaf11 dynein axonemal assembly factor 11 decreases expression EXP carbendazim results in decreased expression of DNAAF11 mRNA CTD PMID:27466211 NCBI chr 7:107,130,402...107,231,507
Ensembl chr 7:107,130,402...107,223,047
JBrowse link
G Dpp7 dipeptidylpeptidase 7 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of DPP7 mRNA CTD PMID:22382377 NCBI chr 3:2,569,135...2,573,387
Ensembl chr 3:2,569,135...2,573,387
JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP carbendazim results in decreased expression of ESR1 mRNA CTD PMID:28576679 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 decreases expression EXP carbendazim results in decreased expression of ESR2 mRNA CTD PMID:28576679 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fank1 fibronectin type III and ankyrin repeat domains 1 increases expression EXP carbendazim results in increased expression of FANK1 mRNA CTD PMID:22952946 NCBI chr 1:205,842,469...205,954,152
Ensembl chr 1:205,842,489...205,950,371
JBrowse link
G Foxa2 forkhead box A2 increases expression ISO carbendazim results in increased expression of FOXA2 mRNA CTD PMID:26071454 NCBI chr 3:142,383,084...142,387,493
Ensembl chr 3:142,383,278...142,387,481
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO carbendazim results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP [carbendazim co-treated with iprodione] results in decreased expression of GJA1 protein CTD PMID:28576679 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Ift81 intraflagellar transport 81 decreases expression EXP carbendazim results in decreased expression of IFT81 mRNA CTD PMID:22952946 PMID:27466211 NCBI chr12:39,420,161...39,507,412
Ensembl chr12:39,423,596...39,506,890
JBrowse link
G Il1b interleukin 1 beta increases expression ISO carbendazim results in increased expression of IL1B mRNA; carbendazim results in increased expression of IL1B protein CTD PMID:26071454 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression ISO carbendazim results in increased expression of IL6 mRNA; carbendazim results in increased expression of IL6 protein CTD PMID:26071454 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itga5 integrin subunit alpha 5 decreases expression ISO carbendazim results in decreased expression of ITGA5 mRNA CTD PMID:25530041 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO carbendazim results in decreased expression of ITGB1 mRNA CTD PMID:25530041 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Loxl1 lysyl oxidase-like 1 multiple interactions
increases expression
EXP 2,5-hexanedione promotes the reaction [carbendazim results in increased expression of LOXL1 protein]; [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of LOXL1 mRNA CTD PMID:22382377 NCBI chr 8:63,067,757...63,092,124
Ensembl chr 8:63,067,300...63,092,009
JBrowse link
G Lpl lipoprotein lipase decreases expression ISO carbendazim results in decreased expression of LPL protein CTD PMID:30496565 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Macrod1 mono-ADP ribosylhydrolase 1 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of MACROD1 mRNA CTD PMID:22382377 NCBI chr 1:222,310,916...222,451,485
Ensembl chr 1:222,310,920...222,451,484
JBrowse link
G Mfap3l microfibril associated protein 3 like increases expression EXP carbendazim results in increased expression of MFAP3L mRNA CTD PMID:22952946 NCBI chr16:32,734,059...32,777,091
Ensembl chr16:32,738,265...32,753,278
JBrowse link
G Mir128-1 microRNA 128-1 increases expression EXP carbendazim results in increased expression of MIR128-1 mRNA CTD PMID:32418910 NCBI chr13:44,916,534...44,916,615
Ensembl chr13:44,916,534...44,916,615
JBrowse link
G Mir423 microRNA 423 increases expression EXP carbendazim results in increased expression of MIR423 mRNA CTD PMID:32418910 NCBI chr10:63,098,366...63,098,444
Ensembl chr10:63,098,360...63,098,453
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO carbendazim results in decreased expression of MMP2 mRNA CTD PMID:25530041 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO carbendazim results in decreased expression of MMP9 mRNA CTD PMID:25530041 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO carbendazim results in increased expression of NFE2L2 protein CTD PMID:30851412 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO carbendazim inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase increases expression EXP carbendazim results in increased expression of PIM1 mRNA CTD PMID:22952946 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO carbendazim results in decreased expression of PLAU mRNA CTD PMID:25530041 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Ptgds prostaglandin D2 synthase decreases expression EXP carbendazim results in decreased expression of PTGDS mRNA CTD PMID:22952946 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Serpine2 serpin family E member 2 increases expression ISO carbendazim results in increased expression of SERPINE2 mRNA CTD PMID:25530041 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] affects the expression of SHANK3 mRNA CTD PMID:22382377 NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679
JBrowse link
G Sil1 SIL1 nucleotide exchange factor decreases expression EXP carbendazim results in decreased expression of SIL1 mRNA CTD PMID:22952946 PMID:27466211 NCBI chr18:28,067,476...28,302,008
Ensembl chr18:28,067,484...28,301,863
JBrowse link
G Sod3 superoxide dismutase 3 increases expression EXP carbendazim results in increased expression of SOD3 mRNA CTD PMID:27466211 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO carbendazim results in increased expression of SREBF1 mRNA CTD PMID:26071454 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tbc1d5 TBC1 domain family, member 5 decreases expression EXP carbendazim results in decreased expression of TBC1D5 mRNA CTD PMID:27466211 NCBI chr 9:1,144,641...1,747,732
Ensembl chr 9:1,145,700...1,746,397
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO carbendazim results in increased expression of TIMP1 mRNA CTD PMID:25530041 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO carbendazim results in increased expression of TIMP2 mRNA CTD PMID:25530041 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tnp1 transition protein 1 increases expression EXP carbendazim results in increased expression of TNP1 mRNA CTD PMID:28576679 NCBI chr 9:80,294,837...80,295,446
Ensembl chr 9:80,294,840...80,295,446
JBrowse link
G Tnp2 transition protein 2 increases expression EXP carbendazim results in increased expression of TNP2 mRNA CTD PMID:28576679 NCBI chr10:4,953,898...4,954,626
Ensembl chr10:4,953,879...4,954,624
JBrowse link
thiabendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin decreases expression EXP Thiabendazole results in decreased expression of ALB mRNA CTD PMID:18539377 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Casp3 caspase 3 increases activity EXP Thiabendazole results in increased activity of CASP3 protein CTD PMID:26748015 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity EXP Thiabendazole results in increased activity of CASP8 protein CTD PMID:26748015 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity EXP Thiabendazole results in increased activity of CASP9 protein CTD PMID:26748015 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Chmp5 charged multivesicular body protein 5 affects expression EXP Thiabendazole affects the expression of CHMP5 mRNA CTD PMID:18539377 NCBI chr 5:57,267,312...57,284,455
Ensembl chr 5:57,267,312...57,284,448
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
EXP
ISO
herbimycin inhibits the reaction [Thiabendazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 protein]
Thiabendazole results in increased expression of CYP1A1 mRNA; Thiabendazole results in increased expression of CYP1A1 protein
CTD PMID:8900397 PMID:10103034 PMID:11226373 PMID:14987951 PMID:15110098 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
affects metabolic processing
decreases activity
ISO
EXP
beta-Naphthoflavone promotes the reaction [CYP1A2 protein affects the metabolism of Thiabendazole]
Thiabendazole results in increased expression of CYP1A2 mRNA; Thiabendazole results in increased expression of CYP1A2 protein
Thiabendazole results in decreased activity of CYP1A2 protein
CTD PMID:10936227 PMID:11124226 PMID:12920490 PMID:15110098 PMID:16261361 PMID:18539377 PMID:18570159 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Thiabendazole results in increased expression of CYP2B1 mRNA; Thiabendazole results in increased expression of CYP2B1 protein CTD PMID:15110098 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Thiabendazole results in increased expression of CYP2B2 mRNA; Thiabendazole results in increased expression of CYP2B2 protein CTD PMID:15110098 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Thiabendazole results in increased expression of CYP2B6 mRNA CTD PMID:18570159 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression ISO Thiabendazole results in increased expression of CYP3A4 mRNA CTD PMID:18570159 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Thiabendazole results in increased expression of GADD45A mRNA CTD PMID:18539377 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
multiple interactions
ISO Thiabendazole results in increased activity of GCLC protein
[Thiabendazole co-treated with Buthionine Sulfoximine] results in increased activity of GCLC protein
CTD PMID:11019651 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Thiabendazole results in increased expression of GSTP1 mRNA CTD PMID:15110098 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP Thiabendazole results in increased expression of GSTT1 mRNA CTD PMID:15110098 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Mpo myeloperoxidase increases metabolic processing ISO MPO protein results in increased metabolism of Thiabendazole metabolite CTD PMID:21513789 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nppb natriuretic peptide B increases expression EXP Thiabendazole results in increased expression of NPPB mRNA CTD PMID:18539377 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Thiabendazole results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 affects expression EXP Thiabendazole affects the expression of OXCT1 mRNA CTD PMID:18539377 NCBI chr 2:53,859,738...54,007,733
Ensembl chr 2:53,859,737...54,007,756
JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 increases expression EXP Thiabendazole results in increased expression of PFKFB1 mRNA CTD PMID:18539377 NCBI chr  X:23,092,143...23,145,923
Ensembl chr  X:23,092,159...23,144,324
JBrowse link
G Prkcb protein kinase C, beta increases expression EXP Thiabendazole results in increased expression of PRKCB mRNA CTD PMID:18539377 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Taf9b TATA-box binding protein associated factor 9b affects expression EXP Thiabendazole affects the expression of TAF9B mRNA CTD PMID:18539377 NCBI chr  X:77,281,234...77,295,238
Ensembl chr  X:77,281,210...77,295,426
JBrowse link
G Tp53 tumor protein p53 increases expression EXP Thiabendazole results in increased expression of TP53 mRNA CTD PMID:18539377 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trim3 tripartite motif-containing 3 increases expression EXP Thiabendazole results in increased expression of TRIM3 mRNA CTD PMID:18539377 NCBI chr 1:170,441,662...170,464,341
Ensembl chr 1:170,441,639...170,464,341
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression EXP Thiabendazole results in increased expression of UGDH mRNA CTD PMID:18539377 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Utrn utrophin increases expression ISO Thiabendazole results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,451,809...6,970,040
Ensembl chr 1:6,451,810...6,970,040
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      application 19401
        pesticide 16584
          fungicide 10739
            benzimidazole fungicide 118
              Cypendazole 0
              Mecarbinzid 0
              benomyl 49
              carbendazim 59
              fuberidazole 0
              thiabendazole 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      p-block molecular entity 19653
                        carbon group molecular entity 19569
                          organic molecular entity 19559
                            organic molecule 19493
                              organic cyclic compound 19318
                                organic heterocyclic compound 18510
                                  organic heteropolycyclic compound 17973
                                    organic heterobicyclic compound 16776
                                      benzimidazoles 864
                                        benzimidazole fungicide 118
                                          Cypendazole 0
                                          Mecarbinzid 0
                                          benomyl 49
                                          carbendazim 59
                                          fuberidazole 0
                                          thiabendazole 26
paths to the root