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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aromatic fungicide
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Accession:CHEBI:87034 term browser browse the term
Definition:An organic aromatic compound that has been used as a fungicide.
Synonyms:related_synonym: aromatic fungicides

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4-chloro-2-methylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding EXP 4-chloro-2-cresol binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
4-nitro-m-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO 4-nitro-3-cresol results in increased expression of BAX protein
Quercetin inhibits the reaction [4-nitro-3-cresol results in increased expression of BAX protein]		 CTD PMID:22467373 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO Quercetin inhibits the reaction [4-nitro-3-cresol results in decreased expression of BCL2L1 protein] CTD PMID:22467373 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO 4-nitro-3-cresol results in increased activity of CASP3 protein
CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein]
Quercetin inhibits the reaction [4-nitro-3-cresol results in increased activity of CASP3 protein]		 CTD PMID:22467373 PMID:29307546 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions		 ISO 4-nitro-3-cresol results in increased activity of CASP8 protein
CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein]		 CTD PMID:29307546 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions		 ISO 4-nitro-3-cresol results in increased expression of FAS mRNA; 4-nitro-3-cresol results in increased expression of FAS protein
CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]		 CTD PMID:29307546 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression		 ISO CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein]
4-nitro-3-cresol results in increased expression of FASL mRNA; 4-nitro-3-cresol results in increased expression of FASL protein
4-nitro-3-cresol results in increased expression of FASLG mRNA; 4-nitro-3-cresol results in increased expression of FASLG protein		 CTD PMID:29307546 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions ISO [4-nitro-3-cresol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD17B4 protein CTD PMID:18336853 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions ISO [4-nitro-3-cresol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of HSD3B2 protein CTD PMID:18336853 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929 		JBrowse link
G Pla2g3 phospholipase A2, group III decreases expression EXP 4-nitro-3-cresol results in decreased expression of PLA2G3 protein CTD PMID:29292090 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614 		JBrowse link
biphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases oxidation ISO CYP1A1 protein results in increased oxidation of diphenyl CTD PMID:27137136 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases oxidation		 ISO diphenyl results in decreased activity of CYP1A2 protein
CYP1A2 protein results in increased oxidation of diphenyl		 CTD PMID:15916432 PMID:27137136 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO diphenyl binds to and results in decreased activity of CYP1B1 protein CTD PMID:19563207 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects binding
increases oxidation		 ISO diphenyl binds to CYP2A13 protein
CYP2A13 protein results in increased oxidation of diphenyl		 CTD PMID:27137136 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO diphenyl results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO diphenyl results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
biphenyl-2-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases activity
multiple interactions		 ISO 2-phenylphenol results in decreased activity of AR protein
2-phenylphenol inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Dihydrotestosterone inhibits the reaction [2-phenylphenol results in increased activity of AR protein]		 CTD PMID:15064155 PMID:18294747 PMID:21310686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene] CTD PMID:10334203 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 2-phenylphenol results in increased expression of CYP1A1 mRNA CTD PMID:23665931 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding ISO 2-phenylphenol binds to CYP1A2 protein CTD PMID:32278787 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression
affects binding
increases expression		 ISO 2-phenylphenol results in decreased expression of ESR1 mRNA
2-phenylphenol binds to ESR1 protein
2-phenylphenol results in increased expression of ESR1 mRNA		 CTD PMID:12598185 PMID:12737316 PMID:12822488 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO 2-phenylphenol results in increased expression of ESR2 mRNA CTD PMID:12737316 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 affects binding ISO 2-phenylphenol binds to FLT1 protein CTD PMID:32278787 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905 		JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [2-phenylphenol results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene; bathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene] CTD PMID:10334203 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686 		JBrowse link
G Mmp9 matrix metallopeptidase 9 affects binding ISO 2-phenylphenol binds to MMP9 protein CTD PMID:32278787 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 2-phenylphenol binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 2-phenylphenol results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Orm1 orosomucoid 1 increases expression ISO 2-phenylphenol results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820 		JBrowse link
G Pgr progesterone receptor increases expression ISO 2-phenylphenol results in increased expression of PGR mRNA CTD PMID:12822488 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO 2-phenylphenol results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [2-phenylphenol binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Serpinb5 serpin family B member 5 affects binding ISO 2-phenylphenol binds to SERPINB5 protein CTD PMID:32278787 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250 		JBrowse link
G Thrb thyroid hormone receptor beta affects binding ISO 2-phenylphenol binds to THRB protein CTD PMID:32278787 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene; bathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene] CTD PMID:10334203 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of 2-phenylphenol CTD PMID:7574722 NCBI chr14:22,375,428...22,486,291
Ensembl chr14:22,375,955...22,534,720 		JBrowse link
G Vdr vitamin D receptor affects binding ISO 2-phenylphenol binds to VDR protein CTD PMID:32278787 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 2-phenylphenol results in increased expression of VEGFA protein CTD PMID:20025956 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
biphenyl-4,4'-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding ISO 4,4'-dihydroxybiphenyl binds to AR protein CTD PMID:12161000 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO 4,4'-dihydroxybiphenyl binds to ESR1 protein CTD PMID:12161000 PMID:12753421 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [4,4'-dihydroxybiphenyl co-treated with Lipopolysaccharides] results in increased expression of PTGS2 CTD PMID:19528508 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
biphenyl-4-amine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO 4-biphenylamine binds to ALB protein CTD PMID:11697451 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Blm BLM RecQ like helicase multiple interactions
decreases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BLM mRNA] CTD PMID:32905825 NCBI chr 1:142,246,773...142,332,616
Ensembl chr 1:142,246,790...142,332,588 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of BRCA1 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCA1 mRNA]		 CTD PMID:24857880 PMID:32905825 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681 		JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 multiple interactions
decreases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCC3 mRNA] CTD PMID:32905825 NCBI chr 9:9,863,380...9,865,920
Ensembl chr 9:9,863,404...9,865,920 		JBrowse link
G Ccnd3 cyclin D3 multiple interactions
decreases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCND3 mRNA] CTD PMID:32905825 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943 		JBrowse link
G Ccne2 cyclin E2 decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of CCNE2 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCNE2 mRNA]		 CTD PMID:32905825 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of CDK1 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK1 mRNA]		 CTD PMID:32905825 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of CDK2 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK2 mRNA]		 CTD PMID:32905825 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of CDKN1A mRNA] CTD PMID:32905825 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO 4-biphenylamine results in decreased expression of CHEK1 mRNA CTD PMID:24857880 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882 		JBrowse link
G Cidea cell death-inducing DFFA-like effector a decreases expression ISO 4-biphenylamine results in decreased expression of CIDEA mRNA CTD PMID:24857880 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions		 ISO 4-biphenylamine results in increased expression of CREB1 protein
Acetylcysteine inhibits the reaction [4-biphenylamine results in increased expression of CREB1 protein]; CREB1 protein affects the reaction [4-biphenylamine results in increased expression of MIR630 mRNA]		 CTD PMID:32433928 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases oxidation EXP CYP1A1 protein results in increased oxidation of 4-biphenylamine CTD PMID:2908851 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases oxidation
multiple interactions
increases metabolic processing
affects metabolic processing		 ISO
EXP		 CYP1A2 protein results in increased activity of 4-biphenylamine
CYP1A2 protein results in increased oxidation of 4-biphenylamine
[furafylline results in decreased activity of CYP1A2 protein] which results in decreased susceptibility to 4-biphenylamine; CYP1A2 protein results in increased hydroxylation of and results in increased activity of 4-biphenylamine
CYP1A2 protein results in increased metabolism of 4-biphenylamine
CYP1A2 protein affects the metabolism of 4-biphenylamine		 CTD PMID:2655891 PMID:2908851 PMID:11376689 PMID:15450435 PMID:16988941 PMID:23898916 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions ISO CYP2A13 protein results in increased hydroxylation of and results in increased activity of 4-biphenylamine CTD PMID:16988941 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases oxidation EXP CYP2B1 protein results in increased oxidation of 4-biphenylamine CTD PMID:2908851 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases hydroxylation
multiple interactions
decreases response to substance		 ISO CYP2E1 protein results in increased hydroxylation of 4-biphenylamine
[CYP2E1 protein results in increased hydroxylation of 4-biphenylamine] which results in increased abundance of Reactive Oxygen Species
CYP2E1 gene mutant form results in decreased susceptibility to 4-biphenylamine		 CTD PMID:25601990 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 increases reduction ISO CYP2S1 protein results in increased reduction of 4-biphenylamine analog CTD PMID:23682735 NCBI chr 1:82,595,211...82,610,350
Ensembl chr 1:82,595,211...82,610,350 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 4-biphenylamine results in increased expression of DDIT3 mRNA CTD PMID:24857880 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Exo1 exonuclease 1 decreases expression ISO 4-biphenylamine results in decreased expression of EXO1 mRNA CTD PMID:24857880 NCBI chr13:93,936,989...93,962,749
Ensembl chr13:93,939,022...93,960,342 		JBrowse link
G Fancg FA complementation group G decreases expression ISO 4-biphenylamine results in decreased expression of FANCG mRNA; 4-biphenylamine results in decreased expression of FANCG protein CTD PMID:24857880 NCBI chr 5:58,448,060...58,456,416
Ensembl chr 5:58,448,822...58,455,819 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of FEN1 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of FEN1 mRNA]		 CTD PMID:24857880 PMID:32905825 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO 4-biphenylamine results in increased expression of GADD45G mRNA CTD PMID:24857880 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein] CTD PMID:32905825 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G H3f4 H3.4 histone decreases methylation
multiple interactions		 ISO 4-biphenylamine results in decreased methylation of H3-4 protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene co-treated with Tetrachlorodibenzodioxin] results in decreased methylation of H3-4 protein		 CTD PMID:17468514 NCBI chr10:45,304,696...45,305,106 JBrowse link
G Hdac2 histone deacetylase 2 decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of HDAC2 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of HDAC2 mRNA]		 CTD PMID:32905825 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO [NAT1 polymorphism results in increased susceptibility to 4-biphenylamine] which results in increased mutagenesis of HPRT1 gene CTD PMID:22114069 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
Ensembl chr  X:158,197,149...158,228,749 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases mutagenesis ISO 4-biphenylamine results in increased mutagenesis of HRAS gene CTD PMID:15761837 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686 		JBrowse link
G Il6 interleukin 6 increases expression ISO 4-biphenylamine results in increased expression of IL6 protein CTD PMID:27746196 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Ip6k3 inositol hexakisphosphate kinase 3 decreases expression ISO 4-biphenylamine results in decreased expression of IP6K3 mRNA CTD PMID:24857880 NCBI chr20:5,733,485...5,754,859
Ensembl chr20:5,733,482...5,754,773 		JBrowse link
G Kdm1a lysine demethylase 1A multiple interactions ISO [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene] affects the localization of KDM1A protein CTD PMID:17468514 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171 		JBrowse link
G Lig1 DNA ligase 1 decreases expression ISO 4-biphenylamine results in decreased expression of LIG1 mRNA CTD PMID:24857880 NCBI chr 1:75,356,212...75,394,757
Ensembl chr 1:75,356,220...75,394,758 		JBrowse link
G Lig4 DNA ligase 4 increases expression
multiple interactions		 ISO 4-biphenylamine results in increased expression of LIG4 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of LIG4 mRNA]		 CTD PMID:32905825 NCBI chr16:85,331,771...85,339,496
Ensembl chr16:85,331,866...85,337,769 		JBrowse link
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [4-biphenylamine results in decreased expression of MCM8 protein] CTD PMID:32433928 NCBI chr 3:125,470,499...125,500,795
Ensembl chr 3:125,470,551...125,500,795 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
multiple interactions		 ISO 4-biphenylamine results in increased expression of MDM2 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of MDM2 mRNA]		 CTD PMID:32905825 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Mir17 microRNA 17 increases expression ISO 4-biphenylamine results in increased expression of MIR17 mRNA CTD PMID:24857880 NCBI chr15:100,179,879...100,179,962
Ensembl chr15:100,179,879...100,179,962 		JBrowse link
G Mir18a microRNA 18a increases expression ISO 4-biphenylamine results in increased expression of MIR18A mRNA CTD PMID:24857880 NCBI chr15:100,180,015...100,180,110
Ensembl chr15:100,180,015...100,180,110 		JBrowse link
G Mir20b microRNA 20b increases expression ISO 4-biphenylamine results in increased expression of MIR20B mRNA CTD PMID:24857880 NCBI chr  X:140,117,518...140,117,589
Ensembl chr  X:140,117,518...140,117,589 		JBrowse link
G Mir21 microRNA 21 increases expression ISO 4-biphenylamine results in increased expression of MIR21 mRNA CTD PMID:24857880 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301 		JBrowse link
G Mir22 microRNA 22 increases expression ISO 4-biphenylamine results in increased expression of MIR22 mRNA CTD PMID:24857880 NCBI chr10:62,299,592...62,299,686
Ensembl chr10:62,299,592...62,299,686 		JBrowse link
G Mir295-1 microRNA 295-1 increases expression ISO 4-biphenylamine results in increased expression of MIR372 mRNA CTD PMID:24857880 NCBI chr 1:64,536,623...64,536,703
Ensembl chr 1:64,536,623...64,536,703 		JBrowse link
G Mir29a microRNA 29a increases expression ISO 4-biphenylamine results in increased expression of MIR29A mRNA CTD PMID:24857880 NCBI chr 4:58,343,931...58,344,018 JBrowse link
G Mir320a microRNA 320a increases expression ISO 4-biphenylamine results in increased expression of MIR320A mRNA CTD PMID:24857880 NCBI chr15:52,134,276...52,134,357
Ensembl chr15:52,134,276...52,134,357 		JBrowse link
G Mir425 microRNA 425 increases expression ISO 4-biphenylamine results in increased expression of MIR425 mRNA CTD PMID:24857880 NCBI chr 8:117,354,821...117,354,903
Ensembl chr 8:117,354,821...117,354,903 		JBrowse link
G Mir431 microRNA 431 increases expression ISO 4-biphenylamine results in increased expression of MIR431 mRNA CTD PMID:24857880 NCBI chr 6:133,711,425...133,711,538
Ensembl chr 6:133,711,425...133,711,538 		JBrowse link
G Mir494 microRNA 494 increases expression ISO 4-biphenylamine results in increased expression of MIR494 mRNA CTD PMID:24857880 NCBI chr 6:133,864,370...133,864,452
Ensembl chr 6:133,864,369...133,864,453 		JBrowse link
G Mir7-1 microRNA 7-1 increases expression ISO 4-biphenylamine results in increased expression of MIR7-1 mRNA CTD PMID:24857880 NCBI chr17:6,675,016...6,675,112
Ensembl chr17:6,675,016...6,675,112 		JBrowse link
G Mir874 microRNA 874 increases expression ISO 4-biphenylamine results in increased expression of MIR874 mRNA CTD PMID:24857880 NCBI chr17:7,025,014...7,025,089
Ensembl chr17:7,025,014...7,025,089 		JBrowse link
G Mir93 microRNA 93 increases expression ISO 4-biphenylamine results in increased expression of MIR93 mRNA CTD PMID:24857880 NCBI chr12:19,307,543...19,307,629
Ensembl chr12:19,307,543...19,307,629 		JBrowse link
G Mirlet7b microRNA let-7b increases expression ISO 4-biphenylamine results in increased expression of MIRLET7B mRNA CTD PMID:24857880 NCBI chr 7:126,590,627...126,590,711
Ensembl chr 7:126,590,627...126,590,711 		JBrowse link
G Mpo myeloperoxidase affects metabolic processing ISO MPO protein affects the metabolism of 4-biphenylamine CTD PMID:9288889 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Msh2 mutS homolog 2 decreases expression ISO 4-biphenylamine results in decreased expression of MSH2 mRNA CTD PMID:24857880 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932 		JBrowse link
G Nat1 N-acetyltransferase 1 increases activity
increases metabolic processing
increases acetylation
multiple interactions
increases response to substance
affects response to substance		 ISO NAT1 protein results in increased activity of 4-biphenylamine
NAT1 protein results in increased metabolism of 4-biphenylamine
NAT1 protein polymorphism results in increased acetylation of 4-biphenylamine; NAT1 protein results in increased acetylation of 4-biphenylamine
[NAT1 polymorphism results in increased susceptibility to 4-biphenylamine] which results in increased mutagenesis of HPRT1 gene
NAT1 polymorphism results in increased susceptibility to 4-biphenylamine; NAT1 protein polymorphism results in increased susceptibility to 4-biphenylamine
NAT1 mRNA alternative form affects the susceptibility to 4-biphenylamine		 CTD PMID:12088197 PMID:15450435 PMID:16815960 PMID:21837760 PMID:22010219 PMID:22114069 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573 		JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
affects response to substance
decreases activity
multiple interactions
increases metabolic processing
increases activity		 ISO
EXP		 NAT2 protein results in increased acetylation of 4-biphenylamine
NAT2 gene polymorphism affects the susceptibility to 4-biphenylamine
4-biphenylamine results in decreased activity of NAT2 protein
4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-aminofluorene]; 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 4-Aminobenzoic Acid]; 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 4-biphenylamine]
NAT2 protein results in increased metabolism of 4-biphenylamine
NAT2 protein results in increased activity of 4-biphenylamine		 CTD PMID:12222688 PMID:15450435 PMID:16815960 PMID:16857729 PMID:18842621 PMID:29180287 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO 4-biphenylamine results in increased expression of and affects the localization of NFE2L2 protein CTD PMID:25601990 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression ISO 4-biphenylamine results in decreased expression of OGG1 mRNA; 4-biphenylamine results in decreased expression of OGG1 protein CTD PMID:16112689 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO 4-biphenylamine results in decreased expression of PCNA mRNA CTD PMID:24857880 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of POLD3 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of POLD3 mRNA]		 CTD PMID:32905825 NCBI chr 1:165,085,142...165,122,385
Ensembl chr 1:165,083,622...165,123,455 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of PRKDC mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of PRKDC mRNA]		 CTD PMID:32905825 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases metabolic processing ISO PTGS1 protein results in increased metabolism of 4-biphenylamine CTD PMID:11159734 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing ISO PTGS2 protein results in increased metabolism of 4-biphenylamine CTD PMID:11159734 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of RAD18 mRNA; 4-biphenylamine results in decreased expression of RAD18 protein
Acetylcysteine inhibits the reaction [4-biphenylamine results in decreased expression of RAD18 protein]		 CTD PMID:24857880 PMID:32433928 NCBI chr 4:144,537,329...144,620,606
Ensembl chr 4:144,536,729...144,620,731 		JBrowse link
G Rad51 RAD51 recombinase decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of RAD51 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD51 mRNA]		 CTD PMID:24857880 PMID:32905825 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917 		JBrowse link
G Rad54b RAD54 homolog B multiple interactions
decreases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD54B mRNA] CTD PMID:32905825 NCBI chr 5:25,140,531...25,214,469
Ensembl chr 5:25,146,949...25,214,376 		JBrowse link
G Rpa1 replication protein A1 decreases expression ISO 4-biphenylamine results in decreased expression of RPA1 mRNA CTD PMID:24857880 NCBI chr10:62,140,419...62,191,518
Ensembl chr10:62,140,419...62,191,512 		JBrowse link
G Rpa2 replication protein A2 multiple interactions
increases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of RPA2 mRNA] CTD PMID:32905825 NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions
decreases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RRM2 mRNA] CTD PMID:32905825 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO 4-biphenylamine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium] CTD PMID:27450509 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO 4-biphenylamine inhibits the reaction [SULT1A1 protein results in increased sulfation of Estradiol] CTD PMID:17433394 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109 		JBrowse link
G Tp53 tumor protein p53 affects response to substance
multiple interactions
decreases expression
affects expression
affects binding		 ISO TP53 protein affects the susceptibility to 4-biphenylamine
Acetylcysteine affects the reaction [4-biphenylamine affects the expression of TP53 protein]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BLM mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCA1 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCC3 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCND3 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCNE2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK1 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of FEN1 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of HDAC2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of POLD3 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of PRKDC mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD51 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD54B mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RRM2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC5 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC6 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of CDKN1A mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of LIG4 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of MDM2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of RPA2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of TP53BP1 mRNA]
4-biphenylamine results in decreased expression of TP53 mRNA
4-biphenylamine binds to TP53 gene		 CTD PMID:11804609 PMID:12376482 PMID:32905825 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions
increases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of TP53BP1 mRNA] CTD PMID:32905825 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790 		JBrowse link
G Tp73 tumor protein p73 decreases expression ISO 4-biphenylamine results in decreased expression of TP73 mRNA CTD PMID:24857880 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354 		JBrowse link
G Trex1 three prime repair exonuclease 1 decreases expression ISO 4-biphenylamine results in decreased expression of TREX1 mRNA CTD PMID:24857880 NCBI chr 8:117,796,127...117,797,427
Ensembl chr 8:117,796,128...117,797,427 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation
multiple interactions		 ISO UGT1A4 protein results in increased glucuronidation of 4-biphenylamine
[Alamethicin results in increased activity of UGT1A4 protein] which results in increased glucuronidation of 4-biphenylamine; hecogenin inhibits the reaction [UGT1A4 protein binds to and results in increased glucuronidation of 4-biphenylamine]; UGT1A4 protein binds to and results in increased glucuronidation of 4-biphenylamine		 CTD PMID:15840509 PMID:17080401 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
multiple interactions		 ISO UGT1A9 protein results in increased glucuronidation of 4-biphenylamine
[Alamethicin results in increased activity of UGT1A9 protein] which affects the glucuronidation of 4-biphenylamine		 CTD PMID:15840509 PMID:17080401 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO 4-biphenylamine results in decreased expression of UNG mRNA CTD PMID:24857880 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822 		JBrowse link
G Xrcc2 X-ray repair cross complementing 2 decreases expression ISO 4-biphenylamine results in decreased expression of XRCC2 mRNA CTD PMID:24857880 NCBI chr 4:5,842,013...5,860,516
Ensembl chr 4:5,841,998...5,860,527 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 decreases expression ISO 4-biphenylamine results in decreased expression of XRCC3 mRNA CTD PMID:24857880 NCBI chr 6:136,366,917...136,380,751
Ensembl chr 6:136,371,555...136,379,348 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 multiple interactions
decreases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC5 mRNA] CTD PMID:32905825 NCBI chr 9:79,659,275...79,748,050
Ensembl chr 9:79,659,251...79,748,078 		JBrowse link
G Xrcc6 X-ray repair cross complementing 6 multiple interactions
decreases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC6 mRNA] CTD PMID:32905825 NCBI chr 7:123,259,881...123,280,613
Ensembl chr 7:123,259,761...123,280,612 		JBrowse link
chlorothalonil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP tetrachloroisophthalonitrile binds to and results in increased activity of AHR protein CTD PMID:14636698 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tetrachloroisophthalonitrile results in increased expression of BAX protein CTD PMID:30586609 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of BCL2 protein CTD PMID:30586609 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bmp15 bone morphogenetic protein 15 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of BMP15 protein CTD PMID:30586609 NCBI chr  X:17,016,831...17,021,894
Ensembl chr  X:17,016,778...17,023,418 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of CYP11A1 protein CTD PMID:30586609 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of DIO1 protein CTD PMID:29228274 PMID:30561685 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520 		JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723 		JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138 		JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation ISO tetrachloroisophthalonitrile results in decreased phosphorylation of EGFR protein CTD PMID:28426875 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases activity ISO tetrachloroisophthalonitrile results in increased activity of ERBB2 protein CTD PMID:11222871 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728 		JBrowse link
G Fshr follicle stimulating hormone receptor decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of FSHR protein CTD PMID:30586609 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817 		JBrowse link
G Gdf9 growth differentiation factor 9 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of GDF9 protein CTD PMID:30586609 NCBI chr10:38,782,519...38,793,238
Ensembl chr10:38,788,992...38,792,940 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of GJA1 protein CTD PMID:30586609 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of HSD17B4 protein CTD PMID:30586609 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of HSD3B1 protein CTD PMID:30586609
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO tetrachloroisophthalonitrile results in decreased phosphorylation of MAPK1 protein CTD PMID:28426875 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO tetrachloroisophthalonitrile results in decreased phosphorylation of MAPK3 protein CTD PMID:28426875 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO tetrachloroisophthalonitrile results in increased activity of NR1I2 protein CTD PMID:20143881 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Rad51 RAD51 recombinase increases expression ISO tetrachloroisophthalonitrile results in increased expression of RAD51 protein CTD PMID:30586609 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
ethiofencarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO croneton inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] CTD PMID:26647222 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
fenamiphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
multiple interactions		 ISO fenamiphos results in decreased activity of ACHE protein
fenamiphos binds to and results in increased phosphorylation of and results in decreased activity of ACHE protein		 CTD PMID:17382909 PMID:17402711 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
affects activity		 ISO fenamiphos binds to and results in increased activity of NR1I2 protein
fenamiphos affects the activity of NR1I2 protein		 CTD PMID:21115097 PMID:23611293 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
fenitrothion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Fenitrothion CTD PMID:12765240 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Ache acetylcholinesterase decreases activity
decreases expression
multiple interactions		 ISO
EXP		 Fenitrothion results in decreased activity of ACHE protein
Fenitrothion results in decreased expression of ACHE protein
Acetylcysteine inhibits the reaction [Fenitrothion results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of ACHE protein]; Quercetin inhibits the reaction [Fenitrothion results in decreased activity of ACHE protein]		 CTD PMID:2086312 PMID:6933967 PMID:30639957 PMID:31173782 PMID:32034696 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Ar androgen receptor multiple interactions
decreases activity
increases expression
affects binding		 ISO Dihydrotestosterone inhibits the reaction [Fenitrothion results in increased activity of AR protein]; Fenitrothion analog binds to and results in decreased activity of AR protein; Fenitrothion inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Fenitrothion inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Fenitrothion inhibits the reaction [Metribolone results in increased activity of AR protein]
Fenitrothion results in decreased activity of AR protein
Fenitrothion results in increased expression of AR mRNA
Fenitrothion binds to AR protein		 CTD PMID:11222873 PMID:12676613 PMID:15064155 PMID:15253041 PMID:18324785 PMID:21251949 PMID:21310686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP Fenitrothion results in increased expression of BAX mRNA; Fenitrothion results in increased expression of BAX protein
Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of BAX mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of BAX mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of BAX mRNA]]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of BAX protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of BAX mRNA]		 CTD PMID:31173782 PMID:32034696 PMID:32572764 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
multiple interactions		 ISO
EXP		 Fenitrothion results in increased expression of BCL2 mRNA
Fenitrothion results in decreased expression of BCL2 mRNA
Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]; Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of BCL2 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of BCL2 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]		 CTD PMID:21298709 PMID:31173782 PMID:32572764 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 EXP Fenitrothion results in increased expression of CASP3 mRNA; Fenitrothion results in increased expression of CASP3 protein
Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of CASP3 protein]; Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of CASP3 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of CASP3 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of CASP3 protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]		 CTD PMID:31173782 PMID:32034696 PMID:32572764 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase multiple interactions
increases activity
decreases activity
decreases expression		 EXP Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of CAT protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of CAT protein]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased activity of CAT protein]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of CAT protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of CAT protein]; Quercetin inhibits the reaction [Fenitrothion results in decreased expression of CAT mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased activity of CAT protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of CAT protein]
Fenitrothion results in decreased expression of CAT mRNA; Fenitrothion results in decreased expression of CAT protein		 CTD PMID:26264430 PMID:30578656 PMID:32034696 PMID:32572764 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cd68 Cd68 molecule increases expression
multiple interactions		 EXP Fenitrothion results in increased expression of CD68 protein
[Fenitrothion co-treated with Potassium Dichromate] results in increased expression of CD68 protein; Plant Extracts inhibits the reaction [[Fenitrothion co-treated with Potassium Dichromate] results in increased expression of CD68 protein]; Plant Extracts inhibits the reaction [Fenitrothion results in increased expression of CD68 protein]		 CTD PMID:30578656 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
multiple interactions
increases expression		 ISO
EXP		 Fenitrothion results in decreased activity of CYP1A1 protein
Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA]		 CTD PMID:15620088 PMID:20183062 PMID:21298709 PMID:30639957 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity		 ISO Fenitrothion results in increased expression of CYP1A2 mRNA
Fenitrothion results in decreased activity of CYP1A2 protein		 CTD PMID:20183062 PMID:22310298 PMID:22634058 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
decreases activity
multiple interactions		 ISO Fenitrothion results in increased expression of CYP2B6 mRNA
Fenitrothion results in decreased activity of CYP2B6 protein
Fenitrothion inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]		 CTD PMID:20183062 PMID:22310298 PMID:22634058 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Fenitrothion results in decreased activity of CYP2C8 protein CTD PMID:20183062 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity		 ISO Fenitrothion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Fenitrothion results in decreased activity of CYP2E1 protein		 CTD PMID:22634058 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity
increases activity
multiple interactions
increases expression		 ISO Fenitrothion results in decreased activity of CYP3A4 protein
Fenitrothion results in increased activity of CYP3A4 protein
[N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA
Fenitrothion results in increased expression of CYP3A4 mRNA		 CTD PMID:17293382 PMID:20183062 PMID:22310298 PMID:25028461 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Faah fatty acid amide hydrolase decreases activity ISO Fenitrothion results in decreased activity of FAAH protein CTD PMID:24361246 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775 		JBrowse link
G Faahl fatty-acid amide hydrolase-like decreases activity ISO Fenitrothion results in decreased activity of FAAH protein CTD PMID:24361246 NCBI chr 5:134,330,204...134,349,400
Ensembl chr 5:134,331,929...134,348,995 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
increases secretion		 EXP Fenitrothion promotes the reaction [Potassium Dichromate results in increased secretion of FSHB protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in increased secretion of FSHB protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in increased secretion of FSHB protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in increased secretion of FSHB protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in increased secretion of FSHB protein] CTD PMID:30578656 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of GFAP protein] CTD PMID:31173782 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
decreases expression		 EXP Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of GSR protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of GSR protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in decreased expression of GSR protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of GSR protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of GSR protein]
Fenitrothion results in decreased activity of GSR protein		 CTD PMID:30578656 PMID:32034696 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions
decreases expression		 EXP Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of GSTA4 mRNA] CTD PMID:30639957 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions
decreases expression		 EXP Quercetin inhibits the reaction [Fenitrothion results in decreased expression of HSD17B3 mRNA] CTD PMID:26264430 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions
decreases expression		 EXP Quercetin inhibits the reaction [Fenitrothion results in decreased expression of HSD3B2 mRNA] CTD PMID:26264430 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929 		JBrowse link
G Ifng interferon gamma decreases expression ISO Fenitrothion results in decreased expression of IFNG protein CTD PMID:12108020 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of IL1B protein] CTD PMID:30639957 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il2 interleukin 2 decreases expression
increases secretion
multiple interactions		 ISO
EXP		 Fenitrothion results in decreased expression of IL2 protein
Fenitrothion results in increased secretion of IL2 protein
Acetylcysteine inhibits the reaction [Fenitrothion results in increased secretion of IL2 protein]		 CTD PMID:12108020 PMID:31173782 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions
decreases activity		 ISO Fenitrothion inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]
Fenitrothion results in decreased activity of LCAT protein		 CTD PMID:4847537 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases secretion
multiple interactions		 EXP Fenitrothion results in decreased secretion of LHB protein
Quercetin inhibits the reaction [Fenitrothion results in decreased secretion of LHB protein]		 CTD PMID:26264430 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724 		JBrowse link
G Mgll monoglyceride lipase decreases activity ISO Fenitrothion analog results in decreased activity of MGLL protein CTD PMID:16449251 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088 		JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO Fenitrothion analog results in decreased activity of NCEH1 protein CTD PMID:16449251 NCBI chr 2:112,868,834...112,932,622
Ensembl chr 2:112,868,707...112,934,953 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression
multiple interactions		 EXP Fenitrothion results in decreased expression of NR5A1 mRNA
Quercetin inhibits the reaction [Fenitrothion results in decreased expression of NR5A1 mRNA]		 CTD PMID:26264430 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441 		JBrowse link
G Pla2g3 phospholipase A2, group III decreases expression EXP Fenitrothion results in decreased expression of PLA2G3 protein CTD PMID:29292090 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases expression
decreases activity		 EXP Fenitrothion promotes the reaction [Vehicle Emissions results in decreased activity of PON1 protein]; Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of PON1 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased activity of PON1 protein]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of PON1 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased activity of PON1 protein]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased expression of PON1 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of PON1 protein]]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of PON1 mRNA]]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of PON1 protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of PON1 mRNA] CTD PMID:32572764 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Fenitrothion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:23770354 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Fenitrothion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions		 EXP Fenitrothion results in decreased expression of SOD1 mRNA
Quercetin inhibits the reaction [Fenitrothion results in decreased expression of SOD1 mRNA]		 CTD PMID:26264430 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression		 EXP Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased secretion of TNF protein] CTD PMID:30639957 PMID:31173782 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of TP53 mRNA] CTD PMID:31173782 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
fenthion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP		 Fenthion results in decreased activity of ACHE protein CTD PMID:1855619 PMID:14976351 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [Fenthion results in increased activity of AR protein]; Fenthion inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:15064155 PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Fenthion results in decreased activity of BCHE protein CTD PMID:24052565 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 affects metabolic processing ISO CYP3A4 protein affects the metabolism of Fenthion CTD PMID:17110060 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing ISO CYP3A5 protein affects the metabolism of Fenthion CTD PMID:17110060 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Fenthion results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520 		JBrowse link
G Esrrg estrogen-related receptor gamma increases activity ISO Fenthion results in increased activity of ESRRG protein CTD PMID:20143881 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases oxidation ISO FMO1 protein results in increased oxidation of Fenthion CTD PMID:14976351 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Fenthion results in increased expression of FOS mRNA CTD PMID:21538558 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Fenthion results in increased expression of GADD45A mRNA CTD PMID:21538558 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Fenthion results in increased expression of HSP90AA1 mRNA alternative form CTD PMID:8792849 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Fenthion results in increased expression of JUN mRNA CTD PMID:21538558 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Fenthion results in increased expression of MYC mRNA CTD PMID:21538558 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Fenthion results in increased expression of NR4A1 CTD PMID:21538558 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Fenthion results in increased expression of PPARG mRNA CTD PMID:32473317 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Fenthion results in increased expression of PPP1R15A mRNA CTD PMID:21538558 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Fenthion results in increased expression of SOCS3 mRNA CTD PMID:21538558 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Fenthion results in increased expression of TNFAIP3 mRNA CTD PMID:21538558 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807 		JBrowse link
flurbiprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta1 actin, alpha 1, skeletal muscle decreases expression ISO Flurbiprofen results in decreased expression of ACTA1 mRNA CTD PMID:16949054 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084 		JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 decreases expression ISO Flurbiprofen results in decreased expression of AKR1B7 mRNA CTD PMID:16949054 NCBI chr 4:61,850,256...61,879,733
Ensembl chr 4:61,850,348...61,862,526 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Flurbiprofen results in decreased activity of AKR1C2 protein CTD PMID:19010312 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
decreases activity		 ISO [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased chemical synthesis of farnesoic acid; [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol CTD PMID:19010312 PMID:21187079 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [Flurbiprofen results in increased phosphorylation of and results in increased activity of PSCA protein] which results in increased expression of AKT1 protein; Akt-I-1,2 compound inhibits the reaction [Flurbiprofen results in increased phosphorylation of and results in increased activity of AKT1 protein]; AKT1 protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]; Flurbiprofen results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:16949054 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alb albumin affects binding ISO Flurbiprofen binds to ALB protein CTD PMID:9353694 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 decreases expression ISO Flurbiprofen results in decreased expression of ALDH7A1 mRNA CTD PMID:16949054 NCBI chr18:51,619,007...51,651,267
Ensembl chr18:51,619,007...51,651,267 		JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A increases expression ISO Flurbiprofen results in increased expression of ANP32A mRNA CTD PMID:16949054 NCBI chr 8:67,295,578...67,333,075
Ensembl chr 8:67,295,727...67,333,247 		JBrowse link
G Anxa1 annexin A1 increases expression ISO Flurbiprofen results in increased expression of ANXA1 mRNA CTD PMID:16949054 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012 		JBrowse link
G Anxa3 annexin A3 increases expression ISO Flurbiprofen results in increased expression of ANXA3 mRNA CTD PMID:16949054 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437 		JBrowse link
G Apod apolipoprotein D increases expression ISO Flurbiprofen results in increased expression of APOD mRNA CTD PMID:16949054 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301 		JBrowse link
G Apof apolipoprotein F increases expression ISO Flurbiprofen results in increased expression of APOF mRNA CTD PMID:16949054 NCBI chr 7:2,689,501...2,690,938
Ensembl chr 7:2,689,501...2,690,936 		JBrowse link
G App amyloid beta precursor protein affects cleavage
decreases secretion
multiple interactions		 ISO
EXP		 Flurbiprofen affects the cleavage of APP protein
Flurbiprofen results in decreased secretion of APP protein
alitretinoin inhibits the reaction [Flurbiprofen results in decreased secretion of APP protein]; Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein]; RXRA protein promotes the reaction [Flurbiprofen results in decreased secretion of APP protein]
Flurbiprofen inhibits the reaction [APP protein results in increased uptake of Calcium]		 CTD PMID:14690522 PMID:17292621 PMID:18648507 PMID:19659691 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Arg1 arginase 1 decreases expression ISO Flurbiprofen results in decreased expression of ARG1 mRNA CTD PMID:16949054 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863 		JBrowse link
G Asic1 acid sensing ion channel subunit 1 decreases activity EXP Flurbiprofen results in decreased activity of ASIC1 protein CTD PMID:11588175 NCBI chr 7:141,324,714...141,354,937
Ensembl chr 7:141,326,321...141,354,937 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO Flurbiprofen results in increased expression of BIRC5 mRNA CTD PMID:16949054 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Flurbiprofen results in increased expression of BNIP3 mRNA CTD PMID:16949054 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]]; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [CALCA protein results in increased susceptibility to Nitroprusside]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein] CTD PMID:8581270 PMID:11166334 PMID:12044622 PMID:12791437 PMID:14991081 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Flurbiprofen results in decreased expression of CCNB1 protein CTD PMID:11687965 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Flurbiprofen results in increased expression of CEACAM1 mRNA CTD PMID:16949054 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345 		JBrowse link
G Ces3a carboxylesterase 3a decreases expression ISO Flurbiprofen results in decreased expression of CES3 mRNA CTD PMID:16949054 NCBI chr19:37,070,705...37,079,411 JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression ISO Flurbiprofen results in increased expression of CITED2 mRNA CTD PMID:16949054 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786 		JBrowse link
G Cmas cytidine monophosphate N-acetylneuraminic acid synthetase increases expression ISO Flurbiprofen results in increased expression of CMAS mRNA CTD PMID:16949054 NCBI chr 4:176,994,129...177,012,445
Ensembl chr 4:176,994,129...177,012,444 		JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 increases expression ISO Flurbiprofen results in increased expression of CMPK2 mRNA CTD PMID:16949054 NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822 		JBrowse link
G Crisp1 cysteine-rich secretory protein 1 decreases expression ISO Flurbiprofen results in decreased expression of CRISP1 mRNA CTD PMID:16949054 NCBI chr 9:24,356,577...24,383,679
Ensembl chr 9:24,356,579...24,383,679 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO
EXP		 Flurbiprofen results in decreased activity of CYP17A1 protein CTD PMID:31184881 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression ISO Flurbiprofen results in decreased expression of CYP24A1 mRNA CTD PMID:16949054 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920 		JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 increases expression ISO Flurbiprofen results in increased expression of CYP2F2 mRNA CTD PMID:16949054 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821 		JBrowse link
G Defb1 defensin beta 1 decreases expression ISO Flurbiprofen results in decreased expression of DEFB1 mRNA CTD PMID:16949054 NCBI chr16:75,294,385...75,309,127
Ensembl chr16:75,294,376...75,309,176 		JBrowse link
G Egf epidermal growth factor increases expression ISO Flurbiprofen results in increased expression of EGF mRNA CTD PMID:16949054 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation
multiple interactions		 ISO Flurbiprofen results in increased phosphorylation of EIF4E protein
MAPK14 protein promotes the reaction [Flurbiprofen results in increased phosphorylation of EIF4E protein]		 CTD PMID:18056468 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631 		JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions
increases expression		 ISO ELAVL1 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; Flurbiprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]
Flurbiprofen results in increased expression of ELAVL1 protein		 CTD PMID:18056468 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432 		JBrowse link
G Eln elastin decreases expression ISO Flurbiprofen results in decreased expression of ELN mRNA CTD PMID:16949054 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 decreases expression ISO Flurbiprofen results in decreased expression of ENPP2 mRNA CTD PMID:16949054 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001 		JBrowse link
G Faah fatty acid amide hydrolase decreases activity EXP Flurbiprofen results in decreased activity of FAAH protein CTD PMID:12751821 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775 		JBrowse link
G Folr1 folate receptor alpha decreases expression ISO Flurbiprofen results in decreased expression of FOLR1 mRNA CTD PMID:16949054 NCBI chr 1:166,934,457...166,945,864
Ensembl chr 1:166,934,460...166,943,592 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO		 Flurbiprofen inhibits the reaction [Carrageenan results in increased expression of FOS protein]; Flurbiprofen promotes the reaction [Urethane inhibits the reaction [Carrageenan results in increased expression of FOS protein]]; Urethane inhibits the reaction [Flurbiprofen inhibits the reaction [Carrageenan results in increased expression of FOS protein]]
Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of FOS mRNA]		 CTD PMID:10864209 PMID:11164833 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions		 ISO Flurbiprofen results in increased expression of GDF15 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]; NGFR protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]		 CTD PMID:21097678 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978 		JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression ISO Flurbiprofen results in decreased expression of GPX3 mRNA CTD PMID:16949054 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression ISO Flurbiprofen results in increased expression of GSTO1 mRNA CTD PMID:16949054 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387 		JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO Flurbiprofen inhibits the reaction [Misonidazole results in increased activity of GUSB protein] CTD PMID:6696821 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771 		JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Flurbiprofen results in increased expression of HELLS mRNA CTD PMID:16949054 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase decreases degradation
increases expression
multiple interactions
increases activity		 ISO Flurbiprofen results in decreased degradation of HPGD protein
Flurbiprofen results in increased expression of HPGD mRNA
[[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein
Flurbiprofen results in increased activity of HPGD protein		 CTD PMID:19501039 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO HRAS protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA] CTD PMID:16949054 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases expression ISO Flurbiprofen results in increased expression of HSD11B2 mRNA CTD PMID:16949054 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Flurbiprofen results in increased expression of ICAM1 protein CTD PMID:16020654 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression ISO Flurbiprofen results in increased expression of IFIT2 mRNA CTD PMID:16949054 NCBI chr 1:252,894,663...252,900,727
Ensembl chr 1:252,894,663...252,900,726 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein] CTD PMID:19659691 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Flurbiprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:10903797 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il11 interleukin 11 multiple interactions ISO Flurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Calcium]; Flurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Dinoprostone] CTD PMID:12110441 NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
Flurbiprofen results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]		 CTD PMID:11112151 PMID:12517972 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Flurbiprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:10903797 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 decreases expression ISO Flurbiprofen results in decreased expression of KCNN4 mRNA CTD PMID:16949054 NCBI chr 1:81,227,855...81,245,986
Ensembl chr 1:81,230,612...81,245,996 		JBrowse link
G Kng2 kininogen 2 multiple interactions EXP Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]] CTD PMID:11166334 PMID:12791437 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lgals3 galectin 3 increases expression ISO Flurbiprofen results in increased expression of LGALS3 mRNA CTD PMID:16949054 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537 		JBrowse link
G Lgals9 galectin 9 decreases expression ISO Flurbiprofen results in decreased expression of LGALS9 mRNA CTD PMID:16949054 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Androstane-3,17-diol]; Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Testosterone] CTD PMID:31184881 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP Flurbiprofen results in decreased expression of LHCGR mRNA; Flurbiprofen results in decreased expression of LHCGR protein CTD PMID:31184881 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439 		JBrowse link
G Lmo7 LIM domain 7 increases expression ISO Flurbiprofen results in increased expression of LMO7 mRNA CTD PMID:16949054 NCBI chr15:86,242,911...86,458,512
Ensembl chr15:86,243,148...86,457,739 		JBrowse link
G Lto1 LTO1 maturation factor of ABCE1 decreases expression ISO Flurbiprofen results in decreased expression of LTO1 mRNA CTD PMID:16949054 NCBI chr 1:218,075,995...218,082,700
Ensembl chr 1:218,076,116...218,080,824 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Flurbiprofen results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:19501039 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 multiple interactions ISO MAPK11 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr 7:130,121,678...130,129,199
Ensembl chr 7:130,121,687...130,128,604 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased phosphorylation of EIF4E protein] CTD PMID:18056468 PMID:21097678 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Flurbiprofen results in decreased phosphorylation of and results in decreased activity of MAPK3 protein CTD PMID:19501039 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions ISO Flurbiprofen results in increased phosphorylation of and results in increased activity of MAPKAPK2 protein; MAPKAPK2 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110 		JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 multiple interactions ISO MAPKAPK3 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr 8:116,012,126...116,046,012
Ensembl chr 8:116,012,121...116,045,954 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO [[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein; [Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA
Flurbiprofen results in decreased expression of MMP9 mRNA		 CTD PMID:19501039 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Msmb microseminoprotein, beta increases expression ISO Flurbiprofen results in increased expression of MSMB mRNA CTD PMID:16949054 NCBI chr16:8,280,275...8,300,853
Ensembl chr16:8,280,275...8,300,852 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:11099482 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression ISO Flurbiprofen results in increased expression of NFKBIZ mRNA CTD PMID:16949054 NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487 		JBrowse link
G Ngfr nerve growth factor receptor multiple interactions
increases expression		 ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of NGFR mRNA]; ELAVL1 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; Flurbiprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]; Flurbiprofen results in increased stability of and results in increased expression of NGFR mRNA; MAPK11 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPKAPK2 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPKAPK3 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; NGFR protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]
Flurbiprofen results in increased expression of NGFR mRNA; Flurbiprofen results in increased expression of NGFR protein		 CTD PMID:17409433 PMID:17447067 PMID:18056468 PMID:21097678 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 EXP
ISO		 Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
Flurbiprofen results in increased expression of NOS2 mRNA
Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites]; Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]		 CTD PMID:8528547 PMID:11405284 PMID:16944022 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity ISO Flurbiprofen results in increased activity of NQO1 protein CTD PMID:8572925 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 increases expression ISO Flurbiprofen results in increased expression of PAPSS2 mRNA CTD PMID:16949054 NCBI chr 1:251,145,264...251,230,716
Ensembl chr 1:251,145,253...251,230,715 		JBrowse link
G Pcp4 Purkinje cell protein 4 decreases expression ISO Flurbiprofen results in decreased expression of PCP4 mRNA CTD PMID:16949054 NCBI chr11:36,851,035...36,912,272
Ensembl chr11:36,851,038...36,912,229 		JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO Flurbiprofen results in increased expression of PDZK1 mRNA CTD PMID:16949054 NCBI chr 2:198,965,685...198,999,323
Ensembl chr 2:198,965,685...198,999,323 		JBrowse link
G Penk proenkephalin decreases expression ISO Flurbiprofen results in decreased expression of PENK mRNA CTD PMID:16949054 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 increases expression ISO Flurbiprofen results in increased expression of PIK3C3 mRNA CTD PMID:16949054 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895 		JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA] CTD PMID:15878913 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693 		JBrowse link
G Psca prostate stem cell antigen multiple interactions
increases expression		 ISO [Flurbiprofen results in increased phosphorylation of and results in increased activity of PSCA protein] which results in increased expression of AKT1 protein; Akt-I-1,2 compound inhibits the reaction [Flurbiprofen results in increased expression of PSCA protein]; AKT1 protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]; HRAS protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA] CTD PMID:16949054 NCBI chr 7:116,090,189...116,091,955
Ensembl chr 7:116,090,189...116,091,955 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO
EXP		 Flurbiprofen results in decreased activity of PTGS1 protein CTD PMID:9233713 PMID:9258749 PMID:18848576 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
decreases degradation
increases expression
decreases expression		 EXP
ISO		 Flurbiprofen inhibits the reaction [Zymosan results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [Zymosan results in increased expression of PTGS2 protein]
Flurbiprofen results in decreased activity of PTGS2 protein
Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]
Flurbiprofen results in decreased degradation of PTGS2 protein; Flurbiprofen results in decreased degradation of PTGS2 protein mutant form
Flurbiprofen results in decreased activity of PTGS2 protein; Flurbiprofen results in decreased activity of PTGS2 protein mutant form
Flurbiprofen results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen results in increased expression of PTGS2 mRNA; Flurbiprofen results in increased expression of PTGS2 protein
Flurbiprofen inhibits the reaction [16,16-Dimethylprostaglandin E2 results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Flurbiprofen results in increased expression of and results in increased activity of PTGS2 protein
Flurbiprofen results in decreased expression of PTGS2 mRNA		 CTD PMID:9099957 PMID:9258749 PMID:9321948 PMID:10594327 PMID:11095985 PMID:11099482 PMID:11112151 PMID:11405284 PMID:11687965 PMID:12517972 PMID:15878913 PMID:16949054 PMID:18848576 PMID:19758985 PMID:22245433 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 Flurbiprofen inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
Flurbiprofen inhibits the reaction [Zymosan results in increased localization of and results in increased activity of RELA protein]		 CTD PMID:11099482 PMID:11291649 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase decreases activity ISO Flurbiprofen results in decreased activity of AKR1C1 protein CTD PMID:19010312 NCBI chr17:69,468,427...69,497,132
Ensembl chr17:69,468,427...69,497,132 		JBrowse link
G Rhog ras homolog family member G increases expression ISO Flurbiprofen results in increased expression of RHOG mRNA CTD PMID:16949054 NCBI chr 1:167,336,147...167,347,720
Ensembl chr 1:167,335,248...167,347,671 		JBrowse link
G Rhou ras homolog family member U increases expression ISO Flurbiprofen results in increased expression of RHOU mRNA CTD PMID:16949054 NCBI chr19:56,431,787...56,443,896
Ensembl chr19:56,435,577...56,441,733 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Flurbiprofen inhibits the reaction [alitretinoin binds to RXRA protein]; RXRA protein promotes the reaction [Flurbiprofen results in decreased secretion of APP protein] CTD PMID:19659691 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908 		JBrowse link
G Sell selectin L decreases expression ISO Flurbiprofen results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631 		JBrowse link
G Smoc2 SPARC related modular calcium binding 2 decreases expression ISO Flurbiprofen results in decreased expression of SMOC2 mRNA CTD PMID:16949054 NCBI chr 1:56,242,289...56,374,106
Ensembl chr 1:56,242,346...56,374,120 		JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression ISO Flurbiprofen results in increased expression of SOX2 mRNA CTD PMID:16949054 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression EXP Flurbiprofen results in decreased expression of SRD5A1 mRNA; Flurbiprofen results in decreased expression of SRD5A1 protein CTD PMID:31184881 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756 		JBrowse link
G Tgoln2 trans-golgi network protein 2 increases expression ISO Flurbiprofen results in increased expression of TGOLN2 mRNA CTD PMID:16949054 NCBI chr 4:100,475,415...100,483,229
Ensembl chr 4:100,475,416...100,483,168 		JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO Flurbiprofen inhibits the reaction [Arachidonic Acid results in decreased expression of THRSP mRNA] CTD PMID:10357836 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions		 ISO Flurbiprofen results in increased expression of TIMP1 protein
[[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein; [Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA		 CTD PMID:19501039 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Flurbiprofen analog promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein]		 CTD PMID:10903797 PMID:19659691 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases response to substance
decreases response to substance
increases expression		 ISO Flurbiprofen results in increased abundance of and results in increased phosphorylation of TP53 protein
TP53 protein results in increased susceptibility to Flurbiprofen
TP53 protein mutant form results in decreased susceptibility to Flurbiprofen
Flurbiprofen results in increased expression of TP53 protein		 CTD PMID:11687965 PMID:15710360 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 decreases expression ISO Flurbiprofen results in decreased expression of TWIST1 mRNA CTD PMID:16949054 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214 		JBrowse link
G Tyms thymidylate synthetase increases expression ISO Flurbiprofen results in increased expression of TYMS mRNA CTD PMID:16949054 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15117964 PMID:15843492 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of Flurbiprofen CTD PMID:8302279 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr14:22,597,103...22,619,968 JBrowse link
hexachlorobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Hexachlorobenzene results in increased expression of ABCC3 mRNA CTD PMID:23153324 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Ackr2 atypical chemokine receptor 2 increases expression EXP Hexachlorobenzene results in increased expression of ACKR2 mRNA CTD PMID:15159207 NCBI chr 8:130,526,521...130,543,566
Ensembl chr 8:130,538,651...130,542,227 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO Hexachlorobenzene results in increased expression of ACTA2 protein CTD PMID:28923513 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression EXP Hexachlorobenzene results in increased expression of AGTR1 protein CTD PMID:29277037 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization
decreases expression
affects expression
increases expression
affects binding
increases localization		 ISO
EXP		 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Hexachlorobenzene results in decreased expression of AHR mRNA]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Hexachlorobenzene; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Hexachlorobenzene; Hexachlorobenzene binds to and results in increased activity of AHR protein; Hexachlorobenzene results in decreased expression of and affects the localization of AHR protein
Hexachlorobenzene affects the localization of AHR protein
Hexachlorobenzene results in decreased expression of AHR protein
Hexachlorobenzene affects the expression of AHR mRNA
Hexachlorobenzene affects the reaction [AHR protein affects the expression of CYP1A1 mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of EGFR mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of IGF1 mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFB1 mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFBR2 mRNA]
Hexachlorobenzene results in increased expression of AHR protein
Hexachlorobenzene binds to AHR protein
[Diethylnitrosamine co-treated with Hexachlorobenzene] results in increased expression of AHR protein; Hexachlorobenzene inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
Hexachlorobenzene results in increased localization of AHR protein		 CTD PMID:2539049 PMID:9407059 PMID:15515957 PMID:16705413 PMID:18295415 PMID:21205633 PMID:26219504 PMID:26358519 PMID:27519288 PMID:28923513 PMID:29277037 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Aif1 allograft inflammatory factor 1 affects expression EXP Hexachlorobenzene affects the expression of AIF1 mRNA CTD PMID:15159207 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
affects localization		 EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Hexachlorobenzene affects the localization of AIFM1 protein]; Reactive Oxygen Species promotes the reaction [Hexachlorobenzene affects the localization of AIFM1 protein] CTD PMID:23708402 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 mRNA]; AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 protein]; Hexachlorobenzene results in increased activity of and results in increased localization of AKT1 protein CTD PMID:16679308 PMID:17150971 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP [Hexachlorobenzene co-treated with Methylnitrosourea] results in increased phosphorylation of AKT2 protein CTD PMID:22245120 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162 		JBrowse link
G Alad aminolevulinate dehydratase affects expression EXP Hexachlorobenzene affects the expression of ALAD mRNA CTD PMID:15159207 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression EXP Hexachlorobenzene results in increased expression of ALAS2 mRNA CTD PMID:15159207 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression EXP Hexachlorobenzene results in increased expression of ALOX15 mRNA CTD PMID:15159207 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein affects expression EXP Hexachlorobenzene affects the expression of ALOX5AP mRNA CTD PMID:15159207 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154 		JBrowse link
G Anxa1 annexin A1 increases expression EXP Hexachlorobenzene results in increased expression of ANXA1 mRNA CTD PMID:15159207 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression EXP Hexachlorobenzene results in decreased expression of BID protein CTD PMID:21787832 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G C1qb complement C1q B chain increases expression EXP Hexachlorobenzene results in increased expression of C1QB mRNA CTD PMID:15159207 NCBI chr 5:155,246,444...155,251,995
Ensembl chr 5:155,246,447...155,252,003 		JBrowse link
G C1s complement C1s increases expression EXP Hexachlorobenzene results in increased expression of C1S mRNA CTD PMID:15159207 NCBI chr 4:157,143,592...157,155,592
Ensembl chr 4:157,143,592...157,155,609 		JBrowse link
G C4bpa complement component 4 binding protein, alpha increases expression EXP Hexachlorobenzene results in increased expression of C4BPA mRNA CTD PMID:15159207 NCBI chr13:47,342,090...47,377,580
Ensembl chr13:47,342,079...47,377,703 		JBrowse link
G Capg capping actin protein, gelsolin like increases expression EXP Hexachlorobenzene results in increased expression of CAPG mRNA CTD PMID:15159207 NCBI chr 4:100,395,693...100,419,447
Ensembl chr 4:100,407,658...100,419,446 		JBrowse link
G Casp1 caspase 1 affects expression EXP Hexachlorobenzene affects the expression of CASP1 mRNA CTD PMID:15159207 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 increases expression
increases activity
multiple interactions		 EXP Hexachlorobenzene results in increased expression of CASP3 mRNA
Hexachlorobenzene results in increased activity of CASP3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorobenzene results in increased activity of CASP3 protein]		 CTD PMID:19815060 PMID:21787832 PMID:23708402 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases activity EXP Hexachlorobenzene results in increased activity of CASP8 protein CTD PMID:21787832 PMID:23708402 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 EXP Hexachlorobenzene results in increased cleavage of and results in increased activity of CASP9 protein
Hexachlorobenzene results in increased activity of CASP9 protein		 CTD PMID:19182106 PMID:21787832 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase increases expression EXP Hexachlorobenzene results in increased expression of CAT mRNA CTD PMID:15159207 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression EXP Hexachlorobenzene results in increased expression of CCL20 mRNA CTD PMID:15159207 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorobenzene results in increased expression of CCND1 protein] CTD PMID:26219504 PMID:28215542 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Hexachlorobenzene promotes the reaction [CDK2 protein binds to CCNE1 protein]; Hexachlorobenzene promotes the reaction [CDKN1B protein binds to CCNE1 protein] CTD PMID:28215542 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Cd14 CD14 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD14 mRNA CTD PMID:15159207 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153 		JBrowse link
G Cd24 CD24 molecule affects expression EXP Hexachlorobenzene affects the expression of CD24 mRNA CTD PMID:15159207 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846 		JBrowse link
G Cd247 Cd247 molecule decreases expression EXP Hexachlorobenzene results in decreased expression of CD3Z mRNA CTD PMID:15159207 NCBI chr13:83,996,045...84,071,408
Ensembl chr13:83,996,080...84,071,400 		JBrowse link
G Cd36 CD36 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD36 mRNA CTD PMID:15159207 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Cd37 CD37 molecule decreases expression EXP Hexachlorobenzene results in decreased expression of CD37 mRNA CTD PMID:15159207 NCBI chr 1:101,230,470...101,236,061
Ensembl chr 1:101,230,533...101,236,065 		JBrowse link
G Cd3d CD3d molecule decreases expression EXP Hexachlorobenzene results in decreased expression of CD3D mRNA CTD PMID:15159207 NCBI chr 8:49,282,502...49,287,095
Ensembl chr 8:49,282,460...49,287,110 		JBrowse link
G Cd48 Cd48 molecule affects expression EXP Hexachlorobenzene affects the expression of CD48 mRNA CTD PMID:15159207 NCBI chr13:90,116,601...90,140,371
Ensembl chr13:90,116,843...90,140,371 		JBrowse link
G Cd5 Cd5 molecule affects expression EXP Hexachlorobenzene affects the expression of CD5 mRNA CTD PMID:15159207 NCBI chr 1:226,770,912...226,791,861
Ensembl chr 1:226,770,744...226,791,879 		JBrowse link
G Cd52 CD52 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD52 mRNA CTD PMID:15159207 NCBI chr 5:152,322,910...152,324,469
Ensembl chr 5:152,322,916...152,324,469 		JBrowse link
G Cd59 CD59 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD59 mRNA CTD PMID:15159207 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621 		JBrowse link
G Cd63 Cd63 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD63 mRNA CTD PMID:15159207 NCBI chr 7:3,320,250...3,335,583
Ensembl chr 7:3,320,103...3,335,582 		JBrowse link
G Cd74 CD74 molecule decreases expression EXP Hexachlorobenzene results in decreased expression of CD74 mRNA CTD PMID:15159207 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849 		JBrowse link
G Cd9 CD9 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD9 mRNA CTD PMID:15159207 NCBI chr 4:157,977,163...158,010,091
Ensembl chr 4:157,977,162...158,010,166 		JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP [Hexachlorobenzene results in decreased activity of GSK3B protein] which results in decreased expression of CDH1 protein CTD PMID:16679308 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO Hexachlorobenzene promotes the reaction [CDK2 protein binds to CCNE1 protein] CTD PMID:28215542 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions		 EXP
ISO		 Hexachlorobenzene results in increased expression of CDKN1B protein
Hexachlorobenzene affects the reaction [CDKN1B protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [CDKN1B protein binds to CCNE1 protein]		 CTD PMID:25093615 PMID:28215542 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases methylation EXP Hexachlorobenzene results in increased methylation of CDKN2A promoter alternative form CTD PMID:26431795 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Cish cytokine inducible SH2-containing protein increases expression EXP Hexachlorobenzene results in increased expression of CISH mRNA CTD PMID:15159207 NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723 		JBrowse link
G Clec4f C-type lectin domain family 4, member F increases expression EXP Hexachlorobenzene results in increased expression of CLEC4F mRNA CTD PMID:15159207 NCBI chr 4:115,322,300...115,332,021
Ensembl chr 4:115,322,291...115,332,052 		JBrowse link
G Cma1 chymase 1 increases expression EXP Hexachlorobenzene results in increased expression of CMA1 mRNA CTD PMID:15159207 NCBI chr15:34,601,037...34,603,819
Ensembl chr15:34,601,037...34,603,819 		JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Hexachlorobenzene results in increased expression of COMT protein CTD PMID:24365113 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622 		JBrowse link
G Cp ceruloplasmin increases expression EXP Hexachlorobenzene results in increased expression of CP mRNA CTD PMID:15159207 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853 		JBrowse link
G Cpa3 carboxypeptidase A3 increases expression EXP Hexachlorobenzene results in increased expression of CPA3 mRNA CTD PMID:15159207 NCBI chr 2:105,016,798...105,047,989
Ensembl chr 2:105,016,626...105,047,984 		JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression EXP Hexachlorobenzene results in increased expression of CSF2RB mRNA CTD PMID:15159207 NCBI chr 7:119,554,383...119,568,248
Ensembl chr 7:119,554,354...119,568,776 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Hexachlorobenzene results in increased expression of CXCL1 mRNA CTD PMID:15159207 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 affects expression EXP Hexachlorobenzene affects the expression of CXCL10 mRNA CTD PMID:15159207 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression EXP Hexachlorobenzene results in increased expression of CXCL5 mRNA CTD PMID:15159207 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression EXP Hexachlorobenzene results in increased expression of CXCR4 mRNA CTD PMID:15159207 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO Hexachlorobenzene results in increased expression of CYP11A1 protein CTD PMID:24365113 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 EXP
ISO		 Hexachlorobenzene results in increased expression of CYP1A1 mRNA; Hexachlorobenzene results in increased expression of CYP1A1 protein
Hexachlorobenzene affects the reaction [AHR protein affects the expression of CYP1A1 mRNA]
Hexachlorobenzene results in increased expression of and results in increased activity of CYP1A1 protein		 CTD PMID:2539049 PMID:2845946 PMID:2856071 PMID:15159207 PMID:17202759 PMID:19879930 PMID:24365113 PMID:27519288 PMID:28923513 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP Hexachlorobenzene results in increased expression of CYP1A2 mRNA; Hexachlorobenzene results in increased expression of CYP1A2 protein CTD PMID:2539049 PMID:2845946 PMID:2856071 PMID:9630449 PMID:10696772 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP Hexachlorobenzene results in increased expression of CYP1B1 mRNA CTD PMID:15159207 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression EXP Hexachlorobenzene results in increased expression of CYP2A3 mRNA CTD PMID:15159207 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Hexachlorobenzene results in increased expression of CYP2B1 protein CTD PMID:10696772 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
increases expression		 EXP Hexachlorobenzene results in decreased expression of CYP2E1 mRNA
Hexachlorobenzene results in increased expression of CYP2E1 protein		 CTD PMID:10696772 PMID:15159207 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP Hexachlorobenzene results in increased expression of CYP3A2 mRNA CTD PMID:15159207 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects expression EXP Hexachlorobenzene affects the expression of CYP3A23-3A1 mRNA CTD PMID:15159207 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 increases expression EXP Hexachlorobenzene results in increased expression of CYP4A8 mRNA CTD PMID:15159207 NCBI chr 5:133,978,953...134,008,255
Ensembl chr 5:133,978,954...134,008,255 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases expression EXP Hexachlorobenzene results in increased expression of CYP7B1 mRNA CTD PMID:15159207 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity
increases activity		 EXP Hexachlorobenzene results in decreased activity of DIO1 protein
Hexachlorobenzene results in increased activity of DIO1 protein		 CTD PMID:15664263 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520 		JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases expression EXP Hexachlorobenzene results in decreased expression of DIO2 mRNA CTD PMID:29277037 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases expression
increases phosphorylation		 ISO
EXP		 [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to Hexachlorobenzene; Hexachlorobenzene results in increased phosphorylation of and results in increased expression of EGFR protein
Hexachlorobenzene results in increased expression of EGFR mRNA
Hexachlorobenzene affects the reaction [AHR protein affects the expression of EGFR mRNA]
AG 1879 inhibits the reaction [SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]]; Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of EGFR protein]; Hexachlorobenzene results in increased phosphorylation of and results in decreased expression of EGFR protein; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]		 CTD PMID:18295415 PMID:21205633 PMID:22245120 PMID:23462309 PMID:28923513 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Emb embigin increases expression EXP Hexachlorobenzene results in increased expression of EMB mRNA CTD PMID:15159207 NCBI chr 2:49,682,763...49,733,475
Ensembl chr 2:49,682,754...49,732,253 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP Hexachlorobenzene results in increased expression of EPHX1 mRNA CTD PMID:15159207 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression EXP Hexachlorobenzene results in decreased expression of EPHX2 mRNA CTD PMID:15159207 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
increases expression
increases phosphorylation		 ISO
EXP		 ESR1 protein affects the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein]; Fulvestrant promotes the reaction [Hexachlorobenzene results in decreased expression of ESR1 protein]
Hexachlorobenzene results in increased expression of ESR1 protein
Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in decreased phosphorylation of ESR1 protein]; Methylnitrosourea inhibits the reaction [Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]]
Hexachlorobenzene results in increased phosphorylation of ESR1 protein		 CTD PMID:19879930 PMID:22245120 PMID:28923513 PMID:29277037 PMID:31923581 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Fas Fas cell surface death receptor increases expression EXP Hexachlorobenzene results in increased expression of FAS protein CTD PMID:21787832 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand increases expression EXP Hexachlorobenzene results in increased expression of FASLG protein CTD PMID:21787832 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fcer1a Fc fragment of IgE receptor Ia increases expression EXP Hexachlorobenzene results in increased expression of FCER1A mRNA CTD PMID:15159207 NCBI chr13:91,727,253...91,737,106
Ensembl chr13:91,730,925...91,737,053 		JBrowse link
G Fcer2 Fc fragment of IgE receptor II decreases expression EXP Hexachlorobenzene results in decreased expression of FCER2A mRNA CTD PMID:15159207 NCBI chr12:2,233,772...2,245,324
Ensembl chr12:2,233,778...2,245,324 		JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa increases expression EXP Hexachlorobenzene results in increased expression of FCGR3 mRNA CTD PMID:15159207 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036 		JBrowse link
G Fcgrt Fc fragment of IgG receptor and transporter increases expression EXP Hexachlorobenzene results in increased expression of FCGRT mRNA CTD PMID:15159207 NCBI chr 1:101,086,872...101,096,159
Ensembl chr 1:101,086,877...101,095,594 		JBrowse link
G Fn1 fibronectin 1 increases expression EXP Hexachlorobenzene results in increased expression of FN1 mRNA CTD PMID:15159207 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Hexachlorobenzene results in increased expression of FOS protein CTD PMID:9630449 PMID:10696772 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
decreases expression		 EXP Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in decreased expression of FSHB protein]
Hexachlorobenzene results in decreased expression of FSHB protein		 CTD PMID:22245120 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP Hexachlorobenzene results in increased expression of GCLM mRNA CTD PMID:15159207 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Gjb1 gap junction protein, beta 1 multiple interactions
decreases expression		 EXP AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 mRNA]; AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 protein]; Estradiol affects the reaction [Hexachlorobenzene results in increased expression of GJB1 mRNA]
Hexachlorobenzene results in decreased expression of GJB1 mRNA; Hexachlorobenzene results in decreased expression of GJB1 protein		 CTD PMID:12117784 PMID:17150971 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977 		JBrowse link
G Gjb2 gap junction protein, beta 2 decreases expression EXP Hexachlorobenzene results in decreased expression of GJB2 mRNA; Hexachlorobenzene results in decreased expression of GJB2 protein CTD PMID:12117784 NCBI chr15:37,377,313...37,394,494
Ensembl chr15:37,377,316...37,383,277 		JBrowse link
G Glg1 golgi glycoprotein 1 affects expression EXP Hexachlorobenzene affects the expression of GLG1 mRNA CTD PMID:15159207 NCBI chr19:42,983,879...43,088,074
Ensembl chr19:42,983,869...43,090,841 		JBrowse link
G Gpx3 glutathione peroxidase 3 affects expression EXP Hexachlorobenzene affects the expression of GPX3 mRNA CTD PMID:15159207 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity
multiple interactions		 EXP Hexachlorobenzene results in decreased activity of GSK3B protein
[Hexachlorobenzene results in decreased activity of GSK3B protein] which results in decreased expression of CDH1 protein		 CTD PMID:16679308 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 affects expression EXP Hexachlorobenzene affects the expression of GSTA2 mRNA CTD PMID:15159207 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP Hexachlorobenzene results in increased expression of GSTA3 mRNA CTD PMID:15159207 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP Hexachlorobenzene results in decreased expression of GSTM1 mRNA CTD PMID:15159207 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP Hexachlorobenzene results in increased expression of GSTM2 mRNA CTD PMID:15159207 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Hexachlorobenzene results in increased expression of GSTP1 protein CTD PMID:9630449 PMID:10696772 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO Hexachlorobenzene results in increased expression of H2AX protein CTD PMID:32156659 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hdc histidine decarboxylase increases expression EXP Hexachlorobenzene results in increased expression of HDC mRNA CTD PMID:15159207 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619 		JBrowse link
G Hmbs hydroxymethylbilane synthase increases expression
increases activity		 EXP Hexachlorobenzene results in increased expression of HMBS mRNA
Hexachlorobenzene increases activity of Hmbs protein in liver		 CTD PMID:15159207, PMID:1781034 RGD:25440495 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
affects expression		 EXP Hexachlorobenzene results in increased expression of HMOX1 mRNA
Hexachlorobenzene affects the expression of HMOX1 mRNA		 CTD PMID:15159207 PMID:22954530 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hp haptoglobin increases expression EXP Hexachlorobenzene results in increased expression of HP mRNA CTD PMID:15159207 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 decreases expression EXP Hexachlorobenzene results in decreased expression of HSD17B2 mRNA CTD PMID:15159207 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression EXP Hexachlorobenzene results in decreased expression of HSP90AB1 mRNA CTD PMID:15159207 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression EXP Hexachlorobenzene results in increased expression of HSPE1 mRNA CTD PMID:15159207 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Hexachlorobenzene results in increased expression of ICAM1 mRNA CTD PMID:15159207 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Ifng interferon gamma affects expression
decreases expression
increases expression		 EXP
ISO		 Hexachlorobenzene affects the expression of IFNG mRNA
Hexachlorobenzene results in decreased expression of IFNG protein
Hexachlorobenzene results in increased expression of IFNG mRNA		 CTD PMID:9465272 PMID:11119253 PMID:11266329 PMID:15319175 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Igf1 insulin-like growth factor 1 affects expression
increases secretion
multiple interactions		 ISO Hexachlorobenzene affects the expression of IGF1 mRNA
Hexachlorobenzene results in increased secretion of IGF1 protein
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of IGF1 mRNA]; 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein]; [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of and results in increased secretion of IGF1 protein; [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of IGF1 mRNA; ESR1 protein affects the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein]
Hexachlorobenzene affects the reaction [AHR protein affects the expression of IGF1 mRNA]		 CTD PMID:28923513 PMID:31923581 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases expression
multiple interactions		 EXP
ISO		 Hexachlorobenzene results in increased expression of IGF1R protein
[Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein; fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein]; fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of IGF1R protein]
Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased expression of IGF1R protein]		 CTD PMID:16237195 PMID:19879930 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 multiple interactions ISO [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] affects the expression of IGFBP2 mRNA CTD PMID:31923581 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions ISO [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] affects the expression of IGFBP3 mRNA CTD PMID:31923581 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374 		JBrowse link
G IgG-2a gamma-2a immunoglobulin heavy chain increases expression EXP Hexachlorobenzene results in increased expression of IGG-2A mRNA CTD PMID:15159207
G Igsf6 immunoglobulin superfamily, member 6 affects expression EXP Hexachlorobenzene affects the expression of IGSF6 mRNA CTD PMID:15159207 NCBI chr 1:190,997,029...191,007,503
Ensembl chr 1:190,997,029...191,007,503 		JBrowse link
G Il10 interleukin 10 affects expression
decreases expression		 EXP
ISO		 Hexachlorobenzene affects the expression of IL10 mRNA; Hexachlorobenzene affects the expression of IL10 protein
Hexachlorobenzene results in decreased expression of IL10 protein		 CTD PMID:11119253 PMID:15319175 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il15 interleukin 15 decreases expression EXP Hexachlorobenzene results in decreased expression of IL15 mRNA CTD PMID:15159207 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594 		JBrowse link
G Il18 interleukin 18 increases expression EXP Hexachlorobenzene results in increased expression of IL18 mRNA CTD PMID:15159207 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Il1b interleukin 1 beta affects expression EXP Hexachlorobenzene affects the expression of IL1B mRNA CTD PMID:15159207 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il2 interleukin 2 increases expression EXP Hexachlorobenzene results in increased expression of IL2 mRNA CTD PMID:9465272 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression EXP Hexachlorobenzene results in increased expression of IL2RA mRNA CTD PMID:9465272 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071 		JBrowse link
G Il2rb interleukin 2 receptor subunit beta affects expression EXP Hexachlorobenzene affects the expression of IL2RB mRNA CTD PMID:15159207 NCBI chr 7:119,701,338...119,716,238
Ensembl chr 7:119,701,251...119,716,238 		JBrowse link
G Il4 interleukin 4 affects expression EXP Hexachlorobenzene affects the expression of IL4 protein CTD PMID:11119253 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il5 interleukin 5 decreases expression ISO Hexachlorobenzene results in decreased expression of IL5 protein CTD PMID:15319175 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587 		JBrowse link
G Il6 interleukin 6 increases expression EXP Hexachlorobenzene results in increased expression of IL6 mRNA CTD PMID:15159207 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer increases expression EXP Hexachlorobenzene results in increased expression of IL6ST mRNA CTD PMID:15159207 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944 		JBrowse link
G Insr insulin receptor increases expression EXP
ISO		 Hexachlorobenzene results in increased expression of INSR protein CTD PMID:16237195 PMID:19879930 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414 		JBrowse link
G Irf1 interferon regulatory factor 1 decreases expression EXP Hexachlorobenzene results in decreased expression of IRF1 mRNA CTD PMID:15159207 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
increases phosphorylation
increases expression		 EXP
ISO		 Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein]
Hexachlorobenzene results in increased phosphorylation of IRS1 protein
[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein; fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]; fulvestrant inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of IRS1 protein]
Hexachlorobenzene results in increased expression of IRS1 protein		 CTD PMID:16237195 PMID:19879930 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Hexachlorobenzene results in increased expression of JUN protein CTD PMID:9630449 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Kdr kinase insert domain receptor increases expression ISO Hexachlorobenzene results in increased expression of KDR protein CTD PMID:26358519 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Hexachlorobenzene results in increased expression of LCN2 mRNA CTD PMID:15159207 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Hexachlorobenzene results in decreased expression of LHB protein CTD PMID:22245120 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724 		JBrowse link
G Lman1 lectin, mannose-binding, 1 increases expression EXP Hexachlorobenzene results in increased expression of LMAN1 mRNA CTD PMID:15159207 NCBI chr18:61,683,377...61,707,344
Ensembl chr18:61,685,117...61,707,317 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 affects expression EXP Hexachlorobenzene affects the expression of MAP3K1 mRNA CTD PMID:15159207 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
affects localization		 ISO
EXP		 [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK1 protein]; Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK1 protein]; Protein Kinase Inhibitors inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK1 protein]
[Hexachlorobenzene results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein
Hexachlorobenzene affects the localization of MAPK1 protein		 CTD PMID:21205633 PMID:21787832 PMID:22245120 PMID:23708402 PMID:26219504 PMID:26358519 PMID:28923513 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects expression EXP Hexachlorobenzene affects the expression of MAPK14 mRNA CTD PMID:15159207 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
affects localization		 ISO
EXP		 [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]; Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]; Protein Kinase Inhibitors inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]
[Hexachlorobenzene results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein
Hexachlorobenzene affects the localization of MAPK3 protein		 CTD PMID:21205633 PMID:22245120 PMID:23708402 PMID:26219504 PMID:26358519 PMID:28923513 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP Hexachlorobenzene results in increased phosphorylation of MAPK8 protein CTD PMID:23708402 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mcpt10 mast cell protease 10 increases expression EXP Hexachlorobenzene results in increased expression of MCPT10 mRNA CTD PMID:15159207 NCBI chr15:34,644,471...34,647,497
Ensembl chr15:34,644,464...34,694,244 		JBrowse link
G Med16 mediator complex subunit 16 decreases expression EXP Hexachlorobenzene results in decreased expression of MED16 mRNA CTD PMID:23153324 NCBI chr 7:12,619,739...12,632,241
Ensembl chr 7:12,542,713...12,632,298 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions		 ISO Hexachlorobenzene results in increased expression of MMP2 mRNA; Hexachlorobenzene results in increased expression of MMP2 protein
AG 1879 inhibits the reaction [Hexachlorobenzene results in increased expression of MMP2 protein]; RTKI cpd inhibits the reaction [Hexachlorobenzene results in increased expression of MMP2 protein]		 CTD PMID:23462309 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions		 EXP
ISO		 Hexachlorobenzene results in increased expression of MMP9 mRNA
alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein]; Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein; RTKI cpd inhibits the reaction [Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein]		 CTD PMID:15159207 PMID:23462309 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mpst mercaptopyruvate sulfurtransferase increases expression EXP Hexachlorobenzene results in increased expression of MPST mRNA CTD PMID:15159207 NCBI chr 7:119,626,636...119,631,317
Ensembl chr 7:119,626,637...119,631,425 		JBrowse link
G Mt1 metallothionein 1 increases expression EXP Hexachlorobenzene results in increased expression of MT1A mRNA CTD PMID:15159207 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression EXP Hexachlorobenzene results in decreased expression of MTOR mRNA CTD PMID:15159207 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO [Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of NFE2L2 protein CTD PMID:28634113 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nos1 nitric oxide synthase 1 affects expression ISO Hexachlorobenzene affects the expression of NOS1 protein CTD PMID:32526215 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341 		JBrowse link
G Nos2 nitric oxide synthase 2 affects expression ISO Hexachlorobenzene affects the expression of NOS2 protein CTD PMID:32526215 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression
affects expression		 EXP
ISO		 Hexachlorobenzene results in decreased expression of NOS3 protein
Hexachlorobenzene affects the expression of NOS3 protein		 CTD PMID:29277037 PMID:32526215 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP Hexachlorobenzene results in increased expression of NQO1 mRNA CTD PMID:23153324 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression EXP Hexachlorobenzene results in decreased expression of NR1D1 mRNA CTD PMID:23153324 NCBI chr10:86,683,875...86,690,815
Ensembl chr10:86,683,875...86,690,815 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Hexachlorobenzene results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Hexachlorobenzene results in increased expression of ORM1 mRNA CTD PMID:15159207 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
increases expression		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorobenzene results in increased expression of PCNA protein]
Hexachlorobenzene results in decreased expression of PCNA protein		 CTD PMID:26219504 PMID:29277037 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Pglyrp1 peptidoglycan recognition protein 1 increases expression EXP Hexachlorobenzene results in increased expression of PGLYRP1 mRNA CTD PMID:15159207 NCBI chr 1:79,790,879...79,796,064
Ensembl chr 1:79,790,705...79,796,111 		JBrowse link
G Plpp2 phospholipid phosphatase 2 increases expression EXP Hexachlorobenzene results in increased expression of PLPP2 mRNA CTD PMID:15159207 NCBI chr 7:13,062,168...13,070,281
Ensembl chr 7:13,062,196...13,070,280 		JBrowse link
G Por cytochrome p450 oxidoreductase decreases expression EXP Hexachlorobenzene results in decreased expression of POR mRNA CTD PMID:15159207 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814 		JBrowse link
G Ppox protoporphyrinogen oxidase affects expression EXP Hexachlorobenzene affects the expression of PPOX mRNA CTD PMID:15159207 NCBI chr13:89,650,094...89,654,998
Ensembl chr13:89,650,094...89,654,244 		JBrowse link
G Prdx2 peroxiredoxin 2 increases expression EXP Hexachlorobenzene results in increased expression of PRDX2 mRNA CTD PMID:15159207 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094 		JBrowse link
G Prl prolactin increases expression EXP Hexachlorobenzene results in increased expression of PRL protein CTD PMID:22245120 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO Hexachlorobenzene results in increased expression of PTGS2 protein
alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]; Fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]; omega-N-Methylarginine inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]		 CTD PMID:26358519 PMID:32526215 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G RatNP-3b defensin RatNP-3 precursor increases expression EXP Hexachlorobenzene results in increased expression of RATNP-3B mRNA CTD PMID:15159207 NCBI chr16:75,528,348...75,530,511
Ensembl chr16:75,497,832...75,530,517 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of RELA protein; Cholecalciferol inhibits the reaction [[Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of RELA protein] CTD PMID:28634113 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rgcc regulator of cell cycle affects expression EXP Hexachlorobenzene affects the expression of RGCC mRNA CTD PMID:15159207 NCBI chr15:61,551,861...61,564,695
Ensembl chr15:61,551,861...61,564,695 		JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression
increases expression		 EXP Hexachlorobenzene affects the expression of RT1-BB mRNA
Hexachlorobenzene results in increased expression of RT1-BB mRNA		 CTD PMID:15159207 PMID:17202759 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711 		JBrowse link
G RT1-Da RT1 class II, locus Da decreases expression EXP Hexachlorobenzene results in decreased expression of RT1-DA mRNA CTD PMID:15159207 NCBI chr20:4,127,644...4,132,616
Ensembl chr20:4,127,644...4,132,616 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression EXP Hexachlorobenzene affects the expression of RT1-DB1 mRNA CTD PMID:15159207 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190 		JBrowse link
G RT1-DMa RT1 class II, locus DMa decreases expression EXP Hexachlorobenzene results in decreased expression of HLA-DMA mRNA CTD PMID:15159207 NCBI chr20:3,935,512...3,938,915
Ensembl chr20:5,240,975...5,244,386 		JBrowse link
G RT1-DMb RT1 class II, locus DMb decreases expression EXP Hexachlorobenzene results in decreased expression of HLA-DMB mRNA CTD PMID:15159207 NCBI chr20:3,945,383...3,952,838
Ensembl chr20:5,227,045...5,234,290
Ensembl chr20:5,227,045...5,234,290 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 increases expression EXP Hexachlorobenzene results in increased expression of RT1-S3 mRNA CTD PMID:15159207 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818 		JBrowse link
G Rxrb retinoid X receptor beta increases activity ISO Hexachlorobenzene results in increased activity of RXRB protein CTD PMID:18207673 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Hexachlorobenzene results in increased expression of S100A8 mRNA CTD PMID:15159207 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Hexachlorobenzene results in increased expression of S100A9 mRNA CTD PMID:15159207 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276 		JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha increases expression EXP Hexachlorobenzene results in increased expression of SCNN1A mRNA CTD PMID:23153324 NCBI chr 4:157,834,339...157,860,472
Ensembl chr 4:157,836,912...157,860,049 		JBrowse link
G Serpina7 serpin family A member 7 decreases expression ISO Hexachlorobenzene results in decreased expression of SERPINA7 protein CTD PMID:19750101 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179 		JBrowse link
G Sh2b3 SH2B adaptor protein 3 decreases expression EXP Hexachlorobenzene results in decreased expression of LNK mRNA CTD PMID:15159207 NCBI chr12:40,261,990...40,265,757
Ensembl chr12:40,244,081...40,265,757 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression EXP Hexachlorobenzene results in decreased expression of SLC2A4 protein CTD PMID:31923579 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions
increases phosphorylation		 ISO AG 1879 inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]; Hexachlorobenzene results in increased phosphorylation of and affects the localization of SMAD3 protein CTD PMID:27519288 PMID:28923513 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 affects expression EXP Hexachlorobenzene affects the expression of SOCS2 mRNA CTD PMID:15159207 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP Hexachlorobenzene results in increased expression of SOCS3 mRNA CTD PMID:15159207 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Hexachlorobenzene results in increased expression of SOD1 mRNA CTD PMID:15159207 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 affects expression EXP Hexachlorobenzene affects the expression of SOD2 mRNA CTD PMID:15159207 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sod3 superoxide dismutase 3 affects expression EXP Hexachlorobenzene affects the expression of SOD3 mRNA CTD PMID:15159207 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
affects localization
increases phosphorylation		 ISO
EXP		 [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of STAT5B protein]; [AG 1879 results in decreased activity of SRC protein] which results in decreased susceptibility to Hexachlorobenzene; Hexachlorobenzene affects the phosphorylation of and affects the activity of SRC protein; Hexachlorobenzene affects the reaction [CDKN1B protein binds to SRC protein]
Hexachlorobenzene affects the localization of SRC protein
Hexachlorobenzene results in increased phosphorylation of SRC protein
AG 1879 inhibits the reaction [SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]]; Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of SRC protein]; Hexachlorobenzene results in increased expression of and results in increased phosphorylation of and results in increased activity of SRC protein; Hexachlorobenzene results in increased phosphorylation of and results in increased expression of SRC protein; Methylnitrosourea inhibits the reaction [Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of SRC protein]; SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]		 CTD PMID:18295415 PMID:19879930 PMID:21205633 PMID:22245120 PMID:23462309 PMID:28215542 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression EXP Hexachlorobenzene results in increased expression of STAT1 mRNA CTD PMID:15159207 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions ISO
EXP		 [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of STAT5B protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein
Hexachlorobenzene affects the expression of and affects the phosphorylation of STAT5B protein		 CTD PMID:21205633 PMID:22245120 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP Hexachlorobenzene results in increased expression of SULT1A1 mRNA CTD PMID:15159207 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 increases expression EXP Hexachlorobenzene results in increased expression of SULT1E1 mRNA CTD PMID:15159207 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248 		JBrowse link
G Tf transferrin increases expression EXP Hexachlorobenzene results in increased expression of TF mRNA CTD PMID:15159207 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333 		JBrowse link
G Tfrc transferrin receptor affects expression EXP Hexachlorobenzene affects the expression of TFRC mRNA CTD PMID:15159207 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO [Hexachlorobenzene co-treated with Diethylnitrosamine co-treated with Cholecalciferol] results in increased expression of TGFA protein; [Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of TGFA protein CTD PMID:28634113 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
affects expression		 EXP
ISO		 Hexachlorobenzene results in increased expression of TGFB1 mRNA; Hexachlorobenzene results in increased expression of TGFB1 protein
Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFB1 mRNA]
Hexachlorobenzene affects the expression of TGFB1 mRNA
alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of TGFB1 mRNA]; Hexachlorobenzene results in increased expression of and results in increased cleavage of TGFB1 protein		 CTD PMID:19182106 PMID:21787832 PMID:25093615 PMID:27519288 PMID:28923513 PMID:29277037 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP Hexachlorobenzene results in decreased expression of TGFB3 mRNA CTD PMID:15159207 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression ISO Hexachlorobenzene results in increased expression of TGFBR1 mRNA CTD PMID:28923513 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions
affects expression		 ISO Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFBR2 mRNA]
Hexachlorobenzene affects the expression of TGFBR2 mRNA		 CTD PMID:28923513 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Hexachlorobenzene results in increased expression of TIMP1 mRNA CTD PMID:15159207 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression EXP Hexachlorobenzene results in increased expression of TIMP2 mRNA CTD PMID:15159207 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Hexachlorobenzene results in increased expression of TNFRSF1A mRNA CTD PMID:15159207 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633 		JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression EXP Hexachlorobenzene results in decreased expression of TSC22D1 mRNA CTD PMID:15159207 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO Hexachlorobenzene affects the expression of and affects the secretion of TSHB protein CTD PMID:19750101 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681 		JBrowse link
G Ttr transthyretin affects binding EXP Hexachlorobenzene binds to TTR protein CTD PMID:2043046 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression
decreases expression		 EXP Hexachlorobenzene results in increased expression of TXNRD1 mRNA
Hexachlorobenzene results in decreased expression of TXNRD1 mRNA		 CTD PMID:23153324 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400 		JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP Hexachlorobenzene results in increased expression of UGT2B1 mRNA CTD PMID:15159207 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444 		JBrowse link
G Ugt8 UDP glycosyltransferase 8 increases expression EXP Hexachlorobenzene results in increased expression of UGT8 mRNA CTD PMID:15159207 NCBI chr 2:229,644,373...229,718,678
Ensembl chr 2:229,644,382...229,718,659 		JBrowse link
G Urod uroporphyrinogen decarboxylase affects expression
multiple interactions		 EXP
ISO		 Hexachlorobenzene affects the expression of UROD mRNA
Hexachlorobenzene promotes the reaction [Aminolevulinic Acid results in decreased activity of UROD protein]		 CTD PMID:8937451 PMID:15159207 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP Hexachlorobenzene results in increased expression of VCAM1 mRNA CTD PMID:15159207 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
G Vdr vitamin D receptor multiple interactions ISO [Hexachlorobenzene co-treated with Diethylnitrosamine] results in decreased expression of VDR protein; Cholecalciferol inhibits the reaction [[Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of VDR protein] CTD PMID:28634113 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166 		JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion
increases expression
multiple interactions		 ISO Hexachlorobenzene results in increased secretion of VEGFA protein
Hexachlorobenzene results in increased expression of VEGFA protein
alpha-naphthoflavone affects the reaction [Hexachlorobenzene results in increased expression of VEGFA protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased secretion of VEGFA protein]; Fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of VEGFA protein]; Hexachlorobenzene results in increased expression of and results in increased secretion of VEGFA protein; omega-N-Methylarginine inhibits the reaction [Hexachlorobenzene results in increased expression of VEGFA protein]		 CTD PMID:26358519 PMID:32526215 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
m-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn4a sodium voltage-gated channel alpha subunit 4 affects activity ISO 3-cresol affects the activity of SCN4A protein polymorphism CTD PMID:11282107 NCBI chr10:94,505,026...94,557,803
Ensembl chr10:94,505,026...94,557,764 		JBrowse link
metolcarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thrb thyroid hormone receptor beta affects binding ISO metolcarb binds to THRB protein CTD PMID:28973306 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282 		JBrowse link
N-hydroxy-4-acetylaminobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nat1 N-acetyltransferase 1 decreases activity ISO N-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT1 protein CTD PMID:15720122 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573 		JBrowse link
G Nat2 N-acetyltransferase 2 decreases activity ISO N-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT2 protein CTD PMID:19842618 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570 		JBrowse link
N-hydroxy-4-aminobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of HRAS gene CTD PMID:11275476 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686 		JBrowse link
G Nat2 N-acetyltransferase 2 increases metabolic processing ISO NAT2 protein results in increased metabolism of N-hydroxy-4-aminobiphenyl CTD PMID:16857729 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions
increases sulfation		 ISO N-hydroxy-4-aminobiphenyl inhibits the reaction [SULT1A1 protein results in increased sulfation of Estradiol]
SULT1A1 protein results in increased sulfation of N-hydroxy-4-aminobiphenyl		 CTD PMID:17433394 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109 		JBrowse link
G Sult1c2a sulfotransferase family, cytosolic, 1C, member 2a increases sulfation ISO SULT1C2 protein results in increased sulfation of N-hydroxy-4-aminobiphenyl CTD PMID:17433394 NCBI chr 9:4,152,588...4,168,355
Ensembl chr 9:4,152,589...4,168,221 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of TP53 gene CTD PMID:11275476 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
nitroflurbiprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 decreases expression ISO nitroflurbiprofen results in decreased expression of CASP1 mRNA CTD PMID:15081244 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Cth cystathionine gamma-lyase multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CTH mRNA] CTD PMID:16491094 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:16491094 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:16491094 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions		 ISO
EXP		 nitroflurbiprofen results in decreased expression of NOS2 mRNA
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]		 CTD PMID:8528547 PMID:15081244 PMID:16491094 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity		 ISO
EXP		 nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]
nitroflurbiprofen results in decreased activity of RELA protein		 CTD PMID:12716482 PMID:16491094 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]		 CTD PMID:12716482 PMID:16491094 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
o-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases expression		 EXP Sodium Selenite inhibits the reaction [2-cresol results in increased expression of AKT1 mRNA] CTD PMID:21705299 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alb albumin affects binding ISO 2-cresol binds to ALB protein CTD PMID:11334365 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP 2-cresol results in increased expression of BAX mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of BAX mRNA]		 CTD PMID:21705299 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO [2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide binds to and results in decreased activity of BCHE protein] which results in increased abundance of 2-cresol CTD PMID:22898212 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 EXP 2-cresol results in increased expression of BCL2 mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of BCL2 mRNA]		 CTD PMID:21705299 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] CTD PMID:11399263 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] CTD PMID:11399263 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] CTD PMID:11399263 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions		 EXP 2-cresol results in increased expression of PPARG mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PPARG mRNA]		 CTD PMID:21705299 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Prkca protein kinase C, alpha increases expression
multiple interactions		 EXP 2-cresol results in increased expression of PRKCA mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PRKCA mRNA]		 CTD PMID:21705299 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP 2-cresol results in increased expression of PTGS2 mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PTGS2 mRNA]		 CTD PMID:21705299 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
p-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO 4-cresol binds to ALB protein CTD PMID:11334365 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Becn1 beclin 1 increases expression ISO
EXP		 4-cresol results in increased expression of BECN1 protein CTD PMID:25668154 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G Casp3 caspase 3 increases activity ISO 4-cresol results in increased activity of CASP3 protein CTD PMID:25668154 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage		 ISO SQSTM1 mutant form inhibits the reaction [4-cresol results in increased cleavage of CASP8 protein] CTD PMID:25668154 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cdh2 cadherin 2 multiple interactions
affects localization		 EXP 4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]; Go 6976 inhibits the reaction [4-cresol affects the localization of CDH2 protein]; Go 6976 inhibits the reaction [4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]] CTD PMID:23466501 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684 		JBrowse link
G Ctnnd1 catenin delta 1 multiple interactions EXP 4-cresol affects the localization of and results in decreased phosphorylation of CTNND1 protein; 4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]; Go 6976 inhibits the reaction [4-cresol affects the localization of and results in decreased phosphorylation of CTNND1 protein]; Go 6976 inhibits the reaction [4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]]; PRKCA mutant form inhibits the reaction [4-cresol affects the localization of and results in decreased phosphorylation of CTNND1 protein] CTD PMID:23466501 NCBI chr 3:72,001,904...72,053,047
Ensembl chr 3:72,002,152...72,053,049 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 multiple interactions ISO 4-cresol inhibits the reaction [IL1B protein results in increased expression of CX3CL1 protein] CTD PMID:16954166 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of 4-cresol CTD PMID:16174805 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of 4-cresol CTD PMID:16174805 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of 4-cresol CTD PMID:16174805 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G F11r F11 receptor decreases expression ISO 4-cresol results in decreased expression of F11R protein CTD PMID:16954166 NCBI chr13:89,826,272...89,850,151
Ensembl chr13:89,826,254...89,850,612 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
decreases phosphorylation		 EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [4-cresol results in decreased phosphorylation of GJA1 protein]; PRKCA mutant form inhibits the reaction [4-cresol results in decreased phosphorylation of GJA1 protein] CTD PMID:22813906 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 4-cresol results in increased expression of HMOX1 mRNA CTD PMID:29214717 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 mRNA]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; 4-cresol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; 4-cresol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:12427124 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 4-cresol inhibits the reaction [IL1B protein results in increased expression of CX3CL1 protein]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 mRNA]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:12427124 PMID:16954166 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO 4-cresol results in increased phosphorylation of JUN protein CTD PMID:25668154 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Mir139 microRNA 139 increases expression ISO 4-cresol results in increased expression of MIR139 mRNA CTD PMID:32105654 NCBI chr 1:166,589,545...166,589,612
Ensembl chr 1:166,589,545...166,589,612 		JBrowse link
G Mir144 microRNA 144 decreases expression ISO 4-cresol results in decreased expression of MIR144 mRNA CTD PMID:32105654 NCBI chr10:65,291,365...65,291,447
Ensembl chr10:65,291,365...65,291,447 		JBrowse link
G Mir186 microRNA 186 increases expression ISO 4-cresol results in increased expression of MIR186 mRNA CTD PMID:32105654 NCBI chr 2:263,873,759...263,873,844
Ensembl chr 2:263,873,759...263,873,844 		JBrowse link
G Mir188 microRNA 188 increases expression ISO 4-cresol results in increased expression of MIR188 mRNA CTD PMID:32105654 NCBI chr  X:16,110,270...16,110,349
Ensembl chr  X:16,110,270...16,110,349 		JBrowse link
G Mir190b microRNA 190b increases expression ISO 4-cresol results in increased expression of MIR190B mRNA CTD PMID:32105654 NCBI chr 2:189,421,137...189,421,214
Ensembl chr 2:189,421,137...189,421,214 		JBrowse link
G Mir196b microRNA 196b decreases expression ISO 4-cresol results in decreased expression of MIR196B mRNA CTD PMID:32105654 NCBI chr 4:82,199,056...82,199,140
Ensembl chr 4:82,199,056...82,199,140 		JBrowse link
G Mir196c microRNA 196c decreases expression ISO 4-cresol results in decreased expression of MIR196A-1 mRNA CTD PMID:32105654 NCBI chr10:84,113,578...84,113,657
Ensembl chr10:84,113,578...84,113,657 		JBrowse link
G Mir200b microRNA 200b decreases expression ISO 4-cresol results in decreased expression of MIR200B mRNA CTD PMID:32105654 NCBI chr 5:173,490,144...173,490,238
Ensembl chr 5:173,490,144...173,490,238 		JBrowse link
G Mir204 microRNA 204 increases expression ISO 4-cresol results in increased expression of MIR204 mRNA CTD PMID:32105654 NCBI chr 1:240,403,000...240,403,109
Ensembl chr 1:240,403,000...240,403,109 		JBrowse link
G Mir20a microRNA 20a increases expression ISO 4-cresol results in increased expression of MIR20A mRNA CTD PMID:32105654 NCBI chr15:100,180,334...100,180,418
Ensembl chr15:100,180,334...100,180,418 		JBrowse link
G Mir324 microRNA 324 increases expression ISO 4-cresol results in increased expression of MIR324 mRNA CTD PMID:32105654 NCBI chr10:56,621,126...56,621,208
Ensembl chr10:56,621,124...56,621,212 		JBrowse link
G Mir331 microRNA 331 increases expression ISO 4-cresol results in increased expression of MIR331 mRNA CTD PMID:32105654 NCBI chr 7:34,881,095...34,881,190
Ensembl chr 7:34,881,095...34,881,190 		JBrowse link
G Mir410 microRNA 410 increases expression ISO 4-cresol results in increased expression of MIR410 mRNA CTD PMID:32105654 NCBI chr 6:133,893,997...133,894,072
Ensembl chr 6:133,893,993...133,894,073 		JBrowse link
G Mir488 microRNA 488 increases expression ISO 4-cresol results in increased expression of MIR488 mRNA CTD PMID:32105654 NCBI chr13:76,198,593...76,198,671
Ensembl chr13:76,198,593...76,198,671 		JBrowse link
G Mir494 microRNA 494 increases expression ISO 4-cresol results in increased expression of MIR494 mRNA CTD PMID:32105654 NCBI chr 6:133,864,370...133,864,452
Ensembl chr 6:133,864,369...133,864,453 		JBrowse link
G Mir541 microRNA 541 increases expression ISO 4-cresol results in increased expression of MIR541 mRNA CTD PMID:32105654 NCBI chr 6:133,892,655...133,892,744
Ensembl chr 6:133,892,655...133,892,744 		JBrowse link
G Mir542 microRNA 542 decreases expression ISO 4-cresol results in decreased expression of MIR542 mRNA CTD PMID:32105654 NCBI chr  X:158,152,146...158,152,224
Ensembl chr  X:158,152,146...158,152,224 		JBrowse link
G Mir877 microRNA 877 increases expression ISO 4-cresol results in increased expression of MIR877 mRNA CTD PMID:32105654 NCBI chr20:3,318,872...3,318,956
Ensembl chr20:3,318,872...3,318,956 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity ISO 4-cresol results in increased activity of MMP2 protein CTD PMID:30910523 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO 4-cresol results in increased expression of and results in increased activity of MMP9 protein; Everolimus inhibits the reaction [4-cresol results in increased expression of MMP9 protein]; Y 27632 inhibits the reaction [4-cresol results in increased expression of MMP9 protein] CTD PMID:30910523 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases phosphorylation		 ISO [Everolimus co-treated with Y 27632] inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein]; Everolimus inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein]; Y 27632 inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein] CTD PMID:30910523 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO 4-cresol results in increased expression of NFE2L2 mRNA CTD PMID:29214717 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 4-cresol results in increased expression of NQO1 mRNA CTD PMID:29214717 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Prkca protein kinase C, alpha increases phosphorylation
increases response to substance
multiple interactions		 EXP 4-cresol results in increased phosphorylation of PRKCA protein
PRKCA protein results in increased susceptibility to 4-cresol
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [4-cresol results in increased phosphorylation of PRKCA protein]; 4-cresol results in increased phosphorylation of and results in increased activity of PRKCA protein; PRKCA mutant form inhibits the reaction [4-cresol affects the localization of and results in decreased phosphorylation of CTNND1 protein]; PRKCA mutant form inhibits the reaction [4-cresol results in decreased phosphorylation of GJA1 protein]		 CTD PMID:22813906 PMID:23466501 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Rhoa ras homolog family member A increases expression
multiple interactions		 ISO 4-cresol results in increased expression of RHOA protein
[Everolimus co-treated with Y 27632] inhibits the reaction [4-cresol results in increased expression of RHOA protein]; Y 27632 inhibits the reaction [4-cresol results in increased expression of RHOA protein]		 CTD PMID:30910523 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167 		JBrowse link
G Snora58 small nucleolar RNA, H/ACA box 58 decreases expression ISO 4-cresol results in decreased expression of MIR3068 mRNA CTD PMID:32105654 NCBI chr 6:111,468,732...111,468,807
Ensembl chr 6:111,468,732...111,468,807 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression		 ISO SQSTM1 mutant form inhibits the reaction [4-cresol results in increased cleavage of CASP8 protein]
4-cresol results in increased expression of SQSTM1 protein		 CTD PMID:25668154 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases metabolic processing EXP SULT1A1 protein results in increased metabolism of 4-cresol CTD PMID:11301044 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 4-cresol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; 4-cresol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; 4-cresol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; 4-cresol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:12427124 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
increases glucuronidation		 ISO Acetaminophen inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 4-cresol]; amentoflavone inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 4-cresol] CTD PMID:32421801 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions
increases glucuronidation		 ISO 4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]; [4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]] which results in increased abundance of Mycophenolic Acid; Niflumic Acid inhibits the reaction [UGT1A9 protein results in increased glucuronidation of 4-cresol] CTD PMID:31742356 PMID:32421801 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of 4-cresol CTD PMID:8302279 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO 4-cresol inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; 4-cresol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; 4-cresol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:12427124 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
pentachloronitrobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsm1 acyl-CoA synthetase medium-chain family member 1 increases expression ISO quintozene results in increased expression of ACSM1 mRNA CTD PMID:17311802 NCBI chr 1:189,359,374...189,395,277
Ensembl chr 1:189,289,957...189,395,276 		JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO quintozene results in increased expression of CES1 mRNA CTD PMID:17311802 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO quintozene results in increased expression of EPHX1 mRNA CTD PMID:17311802 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO quintozene results in increased activity of NFE2L2 protein CTD PMID:30114225 PMID:30203046 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO quintozene results in increased expression of NQO1 mRNA CTD PMID:17311802 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO quintozene binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO quintozene results in increased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO quintozene results in increased activity of PPARG protein CTD PMID:20143881 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
pentachlorophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aass aminoadipate-semialdehyde synthase increases expression ISO Pentachlorophenol results in increased expression of AASS mRNA CTD PMID:23892564 NCBI chr 4:50,152,005...50,208,935
Ensembl chr 4:50,152,452...50,200,328 		JBrowse link
G Abcc12 ATP binding cassette subfamily C member 12 increases expression ISO Pentachlorophenol results in increased expression of ABCC12 mRNA CTD PMID:23892564 NCBI chr19:21,541,324...21,612,757
Ensembl chr19:21,541,742...21,612,527 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Pentachlorophenol results in increased expression of ABCC2 mRNA CTD PMID:23892564 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO Pentachlorophenol results in increased expression of ABCC3 mRNA CTD PMID:23892564 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO Pentachlorophenol results in increased expression of ABCC4 mRNA CTD PMID:23892564 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Pentachlorophenol results in decreased expression of ABCG1 mRNA CTD PMID:23892564 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489 		JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO Pentachlorophenol results in increased expression of ABHD4 mRNA CTD PMID:23892564 NCBI chr15:32,888,233...32,906,861
Ensembl chr15:32,894,938...32,906,850 		JBrowse link
G Abi1 abl-interactor 1 decreases expression ISO Pentachlorophenol results in decreased expression of ABI1 mRNA CTD PMID:23892564 NCBI chr17:89,951,662...90,033,334
Ensembl chr17:89,951,752...90,033,328 		JBrowse link
G Accs 1-aminocyclopropane-1-carboxylate synthase increases expression ISO Pentachlorophenol results in increased expression of ACCS mRNA CTD PMID:23892564 NCBI chr 3:82,742,830...82,757,273
Ensembl chr 3:82,742,831...82,757,204 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression ISO Pentachlorophenol results in increased expression of ACOT1 mRNA CTD PMID:23892564 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression ISO Pentachlorophenol results in increased expression of ACOT2 mRNA CTD PMID:23892564 NCBI chr 6:107,460,596...107,468,324
Ensembl chr 6:107,460,668...107,467,487 		JBrowse link
G Acot4 acyl-CoA thioesterase 4 increases expression ISO Pentachlorophenol results in increased expression of ACOT4 mRNA CTD PMID:23892564 NCBI chr 6:107,517,668...107,522,952
Ensembl chr 6:107,517,668...107,522,952 		JBrowse link
G Acoxl acyl-CoA oxidase-like increases expression ISO Pentachlorophenol results in increased expression of ACOXL mRNA CTD PMID:23892564 NCBI chr 3:120,414,311...120,724,809
Ensembl chr 3:120,414,291...120,726,336 		JBrowse link
G Acp2 acid phosphatase 2, lysosomal decreases expression ISO Pentachlorophenol results in decreased expression of ACP2 mRNA CTD PMID:23892564 NCBI chr 3:80,020,346...80,030,365
Ensembl chr 3:80,021,440...80,030,363 		JBrowse link
G Acsm5 acyl-CoA synthetase medium-chain family member 5 increases expression ISO Pentachlorophenol results in increased expression of ACSM5 mRNA CTD PMID:23892564 NCBI chr 1:189,240,955...189,270,422
Ensembl chr 1:189,233,141...189,272,172 		JBrowse link
G Actg1 actin, gamma 1 increases expression ISO Pentachlorophenol results in increased expression of ACTG1 mRNA CTD PMID:23892564 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954 		JBrowse link
G Actl6a actin-like 6A increases expression ISO Pentachlorophenol results in increased expression of ACTL6A mRNA CTD PMID:23892564 NCBI chr 2:119,112,776...119,128,870
Ensembl chr 2:119,112,513...119,129,751 		JBrowse link
G Actr3 actin related protein 3 increases expression ISO Pentachlorophenol results in increased expression of ACTR3 mRNA CTD PMID:23892564 NCBI chr13:41,695,520...41,738,622
Ensembl chr13:41,695,183...41,738,658 		JBrowse link
G Adar adenosine deaminase, RNA-specific increases expression ISO Pentachlorophenol results in increased expression of ADAR mRNA CTD PMID:23892564 NCBI chr 2:189,045,551...189,085,448
Ensembl chr 2:189,062,443...189,083,236 		JBrowse link
G Adcy3 adenylate cyclase 3 increases expression ISO Pentachlorophenol results in increased expression of ADCY3 mRNA CTD PMID:23892564 NCBI chr 6:28,570,941...28,648,848
Ensembl chr 6:28,571,351...28,650,148 		JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) multiple interactions ISO Pentachlorophenol inhibits the reaction [ADH1C protein results in increased metabolism of Ethanol] CTD PMID:19822198 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide multiple interactions ISO Pentachlorophenol inhibits the reaction [ADH4 protein results in increased metabolism of Ethanol] CTD PMID:19822198 NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899 		JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions ISO Pentachlorophenol inhibits the reaction [ADH5 protein results in increased metabolism of 1-Octanol] CTD PMID:19822198 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide multiple interactions ISO Pentachlorophenol inhibits the reaction [ADH7 protein results in increased metabolism of Ethanol] CTD PMID:19822198 NCBI chr 2:243,500,540...243,516,865
Ensembl chr 2:243,502,073...243,516,532 		JBrowse link
G Adora1 adenosine A1 receptor increases expression ISO Pentachlorophenol results in increased expression of ADORA1 mRNA CTD PMID:23892564 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852 		JBrowse link
G Adrm1 ADRM1 26S proteasome ubiquitin receptor increases expression ISO Pentachlorophenol results in increased expression of ADRM1 mRNA CTD PMID:23892564 NCBI chr 3:175,548,181...175,552,943
Ensembl chr 3:175,548,174...175,552,947 		JBrowse link
G Aftph aftiphilin increases expression ISO Pentachlorophenol results in increased expression of AFTPH mRNA CTD PMID:23892564 NCBI chr14:104,921,633...104,975,763
Ensembl chr14:104,922,282...104,960,141 		JBrowse link
G Agl amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase increases expression ISO Pentachlorophenol results in increased expression of AGL mRNA CTD PMID:23892564 NCBI chr 2:219,788,234...219,843,189
Ensembl chr 2:219,788,234...219,842,986 		JBrowse link
G Agrn agrin increases expression ISO Pentachlorophenol results in increased expression of AGRN mRNA CTD PMID:23892564 NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645 		JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Pentachlorophenol results in increased expression of AHR mRNA CTD PMID:23892564 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression ISO Pentachlorophenol results in increased expression of AHSA1 mRNA CTD PMID:23892564 NCBI chr 6:111,296,168...111,304,224
Ensembl chr 6:111,296,417...111,304,224 		JBrowse link
G Aida axin interactor, dorsalization associated increases expression ISO Pentachlorophenol results in increased expression of AIDA mRNA CTD PMID:23892564 NCBI chr13:101,698,096...101,724,928
Ensembl chr13:101,698,096...101,724,923 		JBrowse link
G Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 increases expression ISO Pentachlorophenol results in increased expression of AIMP2 mRNA CTD PMID:23892564 NCBI chr12:12,738,784...12,748,345
Ensembl chr12:12,738,812...12,748,345 		JBrowse link
G Akap9 A-kinase anchoring protein 9 increases expression ISO Pentachlorophenol results in increased expression of AKAP9 mRNA CTD PMID:23892564 NCBI chr 4:27,195,346...27,331,582
Ensembl chr 4:27,195,346...27,331,582 		JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases expression ISO Pentachlorophenol results in increased expression of AKR1A1 mRNA CTD PMID:23892564 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression ISO Pentachlorophenol results in increased expression of ALAS1 mRNA CTD PMID:23892564 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO Pentachlorophenol results in increased expression of ALDH1A1 mRNA CTD PMID:23892564 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C increases expression ISO Pentachlorophenol results in increased expression of ALDOA mRNA CTD PMID:23892564 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126 		JBrowse link
G Anapc1 anaphase promoting complex subunit 1 increases expression ISO Pentachlorophenol results in increased expression of ANAPC1 mRNA CTD PMID:23892564 NCBI chr 3:121,147,484...121,226,125
Ensembl chr 3:121,147,547...121,226,125 		JBrowse link
G Anapc10 anaphase promoting complex subunit 10 increases expression ISO Pentachlorophenol results in increased expression of ANAPC10 mRNA CTD PMID:23892564 NCBI chr19:31,814,686...31,867,928
Ensembl chr19:31,815,319...31,867,850 		JBrowse link
G Angptl6 angiopoietin-like 6 increases expression ISO Pentachlorophenol results in increa