CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | aromatic fungicide |
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Accession: | CHEBI:87034
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browse the term
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Definition: | An organic aromatic compound that has been used as a fungicide. |
Synonyms: | related_synonym: | aromatic fungicides |
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Ar |
androgen receptor |
affects binding |
EXP |
4-chloro-2-cresol binds to AR protein |
CTD |
PMID:14565775 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO |
4-nitro-3-cresol results in increased expression of BAX protein Quercetin inhibits the reaction [4-nitro-3-cresol results in increased expression of BAX protein] |
CTD |
PMID:22467373 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2l1 |
Bcl2-like 1 |
multiple interactions decreases expression |
ISO |
Quercetin inhibits the reaction [4-nitro-3-cresol results in decreased expression of BCL2L1 protein] |
CTD |
PMID:22467373 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
4-nitro-3-cresol results in increased activity of CASP3 protein CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein] Quercetin inhibits the reaction [4-nitro-3-cresol results in increased activity of CASP3 protein] |
CTD |
PMID:22467373 PMID:29307546 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8 |
caspase 8 |
increases activity multiple interactions |
ISO |
4-nitro-3-cresol results in increased activity of CASP8 protein CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein] |
CTD |
PMID:29307546 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Fas |
Fas cell surface death receptor |
increases expression multiple interactions |
ISO |
4-nitro-3-cresol results in increased expression of FAS mRNA; 4-nitro-3-cresol results in increased expression of FAS protein CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein] |
CTD |
PMID:29307546 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg |
Fas ligand |
multiple interactions increases expression |
ISO |
CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP8 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein] 4-nitro-3-cresol results in increased expression of FASL mRNA; 4-nitro-3-cresol results in increased expression of FASL protein 4-nitro-3-cresol results in increased expression of FASLG mRNA; 4-nitro-3-cresol results in increased expression of FASLG protein |
CTD |
PMID:29307546 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Hsd17b4 |
hydroxysteroid (17-beta) dehydrogenase 4 |
multiple interactions |
ISO |
[4-nitro-3-cresol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD17B4 protein |
CTD |
PMID:18336853 |
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NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
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Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
multiple interactions |
ISO |
[4-nitro-3-cresol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of HSD3B2 protein |
CTD |
PMID:18336853 |
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NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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Pla2g3 |
phospholipase A2, group III |
decreases expression |
EXP |
4-nitro-3-cresol results in decreased expression of PLA2G3 protein |
CTD |
PMID:29292090 |
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NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913
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Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases oxidation |
ISO |
CYP1A1 protein results in increased oxidation of diphenyl |
CTD |
PMID:27137136 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity increases oxidation |
ISO |
diphenyl results in decreased activity of CYP1A2 protein CYP1A2 protein results in increased oxidation of diphenyl |
CTD |
PMID:15916432 PMID:27137136 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
diphenyl binds to and results in decreased activity of CYP1B1 protein |
CTD |
PMID:19563207 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2a1 |
cytochrome P450, family 2, subfamily a, polypeptide 1 |
affects binding increases oxidation |
ISO |
diphenyl binds to CYP2A13 protein CYP2A13 protein results in increased oxidation of diphenyl |
CTD |
PMID:27137136 |
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NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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Esr1 |
estrogen receptor 1 |
decreases activity |
ISO |
diphenyl results in decreased activity of ESR1 protein |
CTD |
PMID:22562034 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
ISO |
diphenyl results in increased activity of NR1I3 protein |
CTD |
PMID:28927721 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Ar |
androgen receptor |
decreases activity multiple interactions |
ISO |
2-phenylphenol results in decreased activity of AR protein 2-phenylphenol inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Dihydrotestosterone inhibits the reaction [2-phenylphenol results in increased activity of AR protein] |
CTD |
PMID:15064155 PMID:18294747 PMID:21310686 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Cat |
catalase |
multiple interactions |
ISO |
CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene] |
CTD |
PMID:10334203 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO |
2-phenylphenol results in increased expression of CYP1A1 mRNA |
CTD |
PMID:23665931 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
affects binding |
ISO |
2-phenylphenol binds to CYP1A2 protein |
CTD |
PMID:32278787 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Esr1 |
estrogen receptor 1 |
decreases expression affects binding increases expression |
ISO |
2-phenylphenol results in decreased expression of ESR1 mRNA 2-phenylphenol binds to ESR1 protein 2-phenylphenol results in increased expression of ESR1 mRNA |
CTD |
PMID:12598185 PMID:12737316 PMID:12822488 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2 |
estrogen receptor 2 |
increases expression |
ISO |
2-phenylphenol results in increased expression of ESR2 mRNA |
CTD |
PMID:12737316 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Flt1 |
Fms related receptor tyrosine kinase 1 |
affects binding |
ISO |
2-phenylphenol binds to FLT1 protein |
CTD |
PMID:32278787 |
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NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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Hexb |
hexosaminidase subunit beta |
multiple interactions |
EXP |
zinc chloride inhibits the reaction [2-phenylphenol results in increased secretion of HEXB protein] |
CTD |
PMID:15272608 |
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NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
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Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene; bathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene] |
CTD |
PMID:10334203 |
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NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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Mmp9 |
matrix metallopeptidase 9 |
affects binding |
ISO |
2-phenylphenol binds to MMP9 protein |
CTD |
PMID:32278787 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
2-phenylphenol binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:21115097 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
ISO |
2-phenylphenol results in increased activity of NR1I3 protein |
CTD |
PMID:28927721 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Orm1 |
orosomucoid 1 |
increases expression |
ISO |
2-phenylphenol results in increased expression of ORM1 protein |
CTD |
PMID:20025956 |
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NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
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Pgr |
progesterone receptor |
increases expression |
ISO |
2-phenylphenol results in increased expression of PGR mRNA |
CTD |
PMID:12822488 |
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NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Phex |
phosphate regulating endopeptidase homolog, X-linked |
increases expression |
ISO |
2-phenylphenol results in increased expression of PHEX protein |
CTD |
PMID:20025956 |
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NCBI chr X:37,607,553...37,856,183
Ensembl chr X:37,610,760...37,854,469
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Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[2-phenylphenol binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 |
CTD |
PMID:26359731 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Serpinb5 |
serpin family B member 5 |
affects binding |
ISO |
2-phenylphenol binds to SERPINB5 protein |
CTD |
PMID:32278787 |
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NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756
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Thrb |
thyroid hormone receptor beta |
affects binding |
ISO |
2-phenylphenol binds to THRB protein |
CTD |
PMID:32278787 |
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NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene; bathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene]; CAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of TP53 gene] |
CTD |
PMID:10334203 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Ugt2b15 |
UDP glucuronosyltransferase family 2 member B15 |
increases metabolic processing |
EXP |
UGT2B15 protein results in increased metabolism of 2-phenylphenol |
CTD |
PMID:7574722 |
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NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
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Vdr |
vitamin D receptor |
affects binding |
ISO |
2-phenylphenol binds to VDR protein |
CTD |
PMID:32278787 |
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NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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Vegfa |
vascular endothelial growth factor A |
increases expression |
ISO |
2-phenylphenol results in increased expression of VEGFA protein |
CTD |
PMID:20025956 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Ar |
androgen receptor |
affects binding |
ISO |
4,4'-dihydroxybiphenyl binds to AR protein |
CTD |
PMID:12161000 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Esr1 |
estrogen receptor 1 |
affects binding |
ISO |
4,4'-dihydroxybiphenyl binds to ESR1 protein |
CTD |
PMID:12161000 PMID:12753421 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[4,4'-dihydroxybiphenyl co-treated with Lipopolysaccharides] results in increased expression of PTGS2 |
CTD |
PMID:19528508 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Alb |
albumin |
affects binding |
ISO |
4-biphenylamine binds to ALB protein |
CTD |
PMID:11697451 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Blm |
BLM RecQ like helicase |
multiple interactions decreases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BLM mRNA] |
CTD |
PMID:32905825 |
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NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
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Brca1 |
BRCA1, DNA repair associated |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of BRCA1 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCA1 mRNA] |
CTD |
PMID:24857880 PMID:32905825 |
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NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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Brcc3 |
BRCA1/BRCA2-containing complex, subunit 3 |
multiple interactions decreases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCC3 mRNA] |
CTD |
PMID:32905825 |
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NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080
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Ccnd3 |
cyclin D3 |
multiple interactions decreases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCND3 mRNA] |
CTD |
PMID:32905825 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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Ccne2 |
cyclin E2 |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of CCNE2 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCNE2 mRNA] |
CTD |
PMID:32905825 |
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NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Cdk1 |
cyclin-dependent kinase 1 |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of CDK1 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK1 mRNA] |
CTD |
PMID:32905825 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdk2 |
cyclin dependent kinase 2 |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of CDK2 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK2 mRNA] |
CTD |
PMID:32905825 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of CDKN1A mRNA] |
CTD |
PMID:32905825 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Chek1 |
checkpoint kinase 1 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of CHEK1 mRNA |
CTD |
PMID:24857880 |
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NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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Cidea |
cell death-inducing DFFA-like effector a |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of CIDEA mRNA |
CTD |
PMID:24857880 |
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NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
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Creb1 |
cAMP responsive element binding protein 1 |
increases expression multiple interactions |
ISO |
4-biphenylamine results in increased expression of CREB1 protein Acetylcysteine inhibits the reaction [4-biphenylamine results in increased expression of CREB1 protein]; CREB1 protein affects the reaction [4-biphenylamine results in increased expression of MIR630 mRNA] |
CTD |
PMID:32433928 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases oxidation |
EXP |
CYP1A1 protein results in increased oxidation of 4-biphenylamine |
CTD |
PMID:2908851 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases activity increases oxidation multiple interactions increases metabolic processing affects metabolic processing |
ISO EXP |
CYP1A2 protein results in increased activity of 4-biphenylamine CYP1A2 protein results in increased oxidation of 4-biphenylamine [furafylline results in decreased activity of CYP1A2 protein] which results in decreased susceptibility to 4-biphenylamine; CYP1A2 protein results in increased hydroxylation of and results in increased activity of 4-biphenylamine CYP1A2 protein results in increased metabolism of 4-biphenylamine CYP1A2 protein affects the metabolism of 4-biphenylamine |
CTD |
PMID:2655891 PMID:2908851 PMID:11376689 PMID:15450435 PMID:16988941 PMID:23898916 More...
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2a1 |
cytochrome P450, family 2, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
CYP2A13 protein results in increased hydroxylation of and results in increased activity of 4-biphenylamine |
CTD |
PMID:16988941 |
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NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases oxidation |
EXP |
CYP2B1 protein results in increased oxidation of 4-biphenylamine |
CTD |
PMID:2908851 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases hydroxylation increases expression multiple interactions decreases response to substance |
ISO |
CYP2E1 protein results in increased hydroxylation of 4-biphenylamine 4-biphenylamine results in increased expression of CYP2E1 protein [Propolis co-treated with allyl sulfide] inhibits the reaction [4-biphenylamine results in increased expression of CYP2E1 protein]; allyl sulfide inhibits the reaction [4-biphenylamine results in increased expression of CYP2E1 protein]; Propolis inhibits the reaction [4-biphenylamine results in increased expression of CYP2E1 protein] [CYP2E1 protein results in increased hydroxylation of 4-biphenylamine] which results in increased abundance of Reactive Oxygen Species CYP2E1 gene mutant form results in decreased susceptibility to 4-biphenylamine |
CTD |
PMID:25601990 PMID:33847444 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp2s1 |
cytochrome P450, family 2, subfamily s, polypeptide 1 |
increases reduction |
ISO |
CYP2S1 protein results in increased reduction of 4-biphenylamine analog |
CTD |
PMID:23682735 |
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NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
4-biphenylamine results in increased expression of DDIT3 mRNA |
CTD |
PMID:24857880 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Exo1 |
exonuclease 1 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of EXO1 mRNA |
CTD |
PMID:24857880 |
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NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
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G |
Fancg |
FA complementation group G |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of FANCG mRNA; 4-biphenylamine results in decreased expression of FANCG protein |
CTD |
PMID:24857880 |
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NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029
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G |
Fen1 |
flap structure-specific endonuclease 1 |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of FEN1 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of FEN1 mRNA] |
CTD |
PMID:24857880 PMID:32905825 |
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NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
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G |
Gadd45g |
growth arrest and DNA-damage-inducible, gamma |
increases expression |
ISO |
4-biphenylamine results in increased expression of GADD45G mRNA |
CTD |
PMID:24857880 |
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NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
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G |
H2ax |
H2A.X variant histone |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein]; Propolis inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein] |
CTD |
PMID:32433928 PMID:32905825 PMID:33847444 |
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NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
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G |
H3f4 |
H3.4 histone |
decreases methylation multiple interactions |
ISO |
4-biphenylamine results in decreased methylation of H3-4 protein [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene co-treated with Tetrachlorodibenzodioxin] results in decreased methylation of H3-4 protein |
CTD |
PMID:17468514 |
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NCBI chr10:43,740,797...43,741,207
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G |
Hdac2 |
histone deacetylase 2 |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of HDAC2 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of HDAC2 mRNA] |
CTD |
PMID:32905825 |
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NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609
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G |
Hprt1 |
hypoxanthine phosphoribosyltransferase 1 |
multiple interactions |
ISO |
[NAT1 polymorphism results in increased susceptibility to 4-biphenylamine] which results in increased mutagenesis of HPRT1 gene |
CTD |
PMID:22114069 |
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NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
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G |
Hras |
HRas proto-oncogene, GTPase |
increases mutagenesis |
ISO |
4-biphenylamine results in increased mutagenesis of HRAS gene |
CTD |
PMID:15761837 |
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NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Il6 |
interleukin 6 |
increases expression |
ISO |
4-biphenylamine results in increased expression of IL6 protein |
CTD |
PMID:27746196 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ip6k3 |
inositol hexakisphosphate kinase 3 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of IP6K3 mRNA |
CTD |
PMID:24857880 |
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NCBI chr20:5,223,863...5,245,443
Ensembl chr20:5,224,120...5,245,428
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G |
Kdm1a |
lysine demethylase 1A |
multiple interactions |
ISO |
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene] affects the localization of KDM1A protein |
CTD |
PMID:17468514 |
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NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319
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G |
Lig1 |
DNA ligase 1 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of LIG1 mRNA |
CTD |
PMID:24857880 |
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NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413
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G |
Lig4 |
DNA ligase 4 |
increases expression multiple interactions |
ISO |
4-biphenylamine results in increased expression of LIG4 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of LIG4 mRNA] |
CTD |
PMID:32905825 |
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NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040
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G |
Mcm8 |
minichromosome maintenance 8 homologous recombination repair factor |
multiple interactions decreases expression |
ISO |
Acetylcysteine inhibits the reaction [4-biphenylamine results in decreased expression of MCM8 protein] |
CTD |
PMID:32433928 |
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NCBI chr 3:120,086,741...120,117,008
Ensembl chr 3:120,086,763...120,117,008
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G |
Mdm2 |
MDM2 proto-oncogene |
increases expression multiple interactions |
ISO |
4-biphenylamine results in increased expression of MDM2 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of MDM2 mRNA] |
CTD |
PMID:32905825 |
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NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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G |
Mir17 |
microRNA 17 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR17 mRNA |
CTD |
PMID:24857880 |
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NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712
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G |
Mir18a |
microRNA 18a |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR18A mRNA |
CTD |
PMID:24857880 |
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NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860
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G |
Mir20b |
microRNA 20b |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR20B mRNA |
CTD |
PMID:24857880 |
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NCBI chr X:132,422,211...132,422,282
Ensembl chr X:132,422,211...132,422,282
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G |
Mir21 |
microRNA 21 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR21 mRNA |
CTD |
PMID:24857880 |
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NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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G |
Mir22 |
microRNA 22 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR22 mRNA |
CTD |
PMID:24857880 |
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NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
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G |
Mir295-1 |
microRNA 295-1 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR372 mRNA |
CTD |
PMID:24857880 |
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NCBI chr 1:65,962,566...65,962,646
Ensembl chr 1:65,962,566...65,962,646
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G |
Mir29a |
microRNA 29a |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR29A mRNA |
CTD |
PMID:24857880 |
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NCBI chr 4:59,650,608...59,650,695
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G |
Mir320a |
microRNA 320a |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR320A mRNA |
CTD |
PMID:24857880 |
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NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473
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G |
Mir340-1 |
microRNA mir-340-1 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR340 mRNA |
CTD |
PMID:24857880 |
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NCBI chr10:34,393,568...34,393,665
Ensembl chr10:34,393,568...34,393,665
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G |
Mir425 |
microRNA 425 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR425 mRNA |
CTD |
PMID:24857880 |
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NCBI chr 8:109,264,555...109,264,637
Ensembl chr 8:109,264,555...109,264,637
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G |
Mir431 |
microRNA 431 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR431 mRNA |
CTD |
PMID:24857880 |
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NCBI chr 6:128,544,210...128,544,323
Ensembl chr 6:128,544,210...128,544,323
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G |
Mir494 |
microRNA 494 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR494 mRNA |
CTD |
PMID:24857880 |
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NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793
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G |
Mir7-1 |
microRNA 7-1 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR7-1 mRNA |
CTD |
PMID:24857880 |
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NCBI chr17:6,273,264...6,273,360
Ensembl chr17:6,273,264...6,273,360
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G |
Mir874 |
microRNA 874 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR874 mRNA |
CTD |
PMID:24857880 |
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NCBI chr17:6,620,649...6,620,724
Ensembl chr17:6,620,649...6,620,724
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G |
Mir93 |
microRNA 93 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR93 mRNA |
CTD |
PMID:24857880 |
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NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221
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G |
Mirlet7b |
microRNA let-7b |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIRLET7B mRNA |
CTD |
PMID:24857880 |
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NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270
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G |
Mpo |
myeloperoxidase |
affects metabolic processing |
ISO |
MPO protein affects the metabolism of 4-biphenylamine |
CTD |
PMID:9288889 |
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NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Msh2 |
mutS homolog 2 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of MSH2 mRNA |
CTD |
PMID:24857880 |
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NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
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G |
Nat1 |
N-acetyltransferase 1 |
increases activity increases metabolic processing increases acetylation multiple interactions increases response to substance affects response to substance |
ISO |
NAT1 protein results in increased activity of 4-biphenylamine NAT1 protein results in increased metabolism of 4-biphenylamine NAT1 protein polymorphism results in increased acetylation of 4-biphenylamine; NAT1 protein results in increased acetylation of 4-biphenylamine [NAT1 polymorphism results in increased susceptibility to 4-biphenylamine] which results in increased mutagenesis of HPRT1 gene NAT1 polymorphism results in increased susceptibility to 4-biphenylamine; NAT1 protein polymorphism results in increased susceptibility to 4-biphenylamine NAT1 mRNA alternative form affects the susceptibility to 4-biphenylamine |
CTD |
PMID:12088197 PMID:15450435 PMID:16815960 PMID:21837760 PMID:22010219 PMID:22114069 More...
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NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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G |
Nat2 |
N-acetyltransferase 2 |
increases acetylation increases metabolic processing affects response to substance decreases activity multiple interactions increases activity |
ISO EXP |
NAT2 protein results in increased acetylation of 4-biphenylamine NAT2 protein results in increased metabolism of 4-biphenylamine NAT2 gene polymorphism affects the susceptibility to 4-biphenylamine 4-biphenylamine results in decreased activity of NAT2 protein 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-aminofluorene]; 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 4-Aminobenzoic Acid]; 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 4-biphenylamine] NAT2 protein results in increased activity of 4-biphenylamine |
CTD |
PMID:12222688 PMID:15450435 PMID:16815960 PMID:16857729 PMID:18842621 PMID:29180287 PMID:33136180 More...
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NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
4-biphenylamine results in increased expression of and affects the localization of NFE2L2 protein |
CTD |
PMID:25601990 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Ogg1 |
8-oxoguanine DNA glycosylase |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of OGG1 mRNA; 4-biphenylamine results in decreased expression of OGG1 protein Propolis inhibits the reaction [4-biphenylamine results in decreased expression of OGG1 protein] |
CTD |
PMID:16112689 PMID:33847444 |
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NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
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G |
Pcna |
proliferating cell nuclear antigen |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of PCNA mRNA |
CTD |
PMID:24857880 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pold3 |
DNA polymerase delta 3, accessory subunit |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of POLD3 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of POLD3 mRNA] |
CTD |
PMID:32905825 |
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NCBI chr 1:154,417,893...154,456,687
Ensembl chr 1:154,418,084...154,456,665
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G |
Prkdc |
protein kinase, DNA-activated, catalytic subunit |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of PRKDC mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of PRKDC mRNA] |
CTD |
PMID:32905825 |
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NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
increases metabolic processing |
ISO |
PTGS1 protein results in increased metabolism of 4-biphenylamine |
CTD |
PMID:11159734 |
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NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases metabolic processing |
ISO |
PTGS2 protein results in increased metabolism of 4-biphenylamine |
CTD |
PMID:11159734 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Rad18 |
RAD18 E3 ubiquitin protein ligase |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of RAD18 mRNA; 4-biphenylamine results in decreased expression of RAD18 protein Acetylcysteine inhibits the reaction [4-biphenylamine results in decreased expression of RAD18 protein] |
CTD |
PMID:24857880 PMID:32433928 |
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NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069
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G |
Rad51 |
RAD51 recombinase |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of RAD51 mRNA; 4-biphenylamine results in decreased expression of RAD51 protein Propolis inhibits the reaction [4-biphenylamine results in decreased expression of RAD51 protein]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD51 mRNA] |
CTD |
PMID:24857880 PMID:32905825 PMID:33847444 |
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NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
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G |
Rad54b |
RAD54 homolog B |
multiple interactions decreases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD54B mRNA] |
CTD |
PMID:32905825 |
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NCBI chr 5:25,030,885...25,104,616
Ensembl chr 5:25,032,066...25,104,616
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G |
Rpa1 |
replication protein A1 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of RPA1 mRNA |
CTD |
PMID:24857880 |
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NCBI chr10:60,148,869...60,199,999
Ensembl chr10:60,148,793...60,199,949
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G |
Rpa2 |
replication protein A2 |
multiple interactions increases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of RPA2 mRNA] |
CTD |
PMID:32905825 |
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NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
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G |
Rrm2 |
ribonucleotide reductase regulatory subunit M2 |
multiple interactions decreases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RRM2 mRNA] |
CTD |
PMID:32905825 |
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NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
4-biphenylamine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium] |
CTD |
PMID:27450509 |
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NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
multiple interactions |
ISO |
4-biphenylamine inhibits the reaction [SULT1A1 protein results in increased sulfation of Estradiol] |
CTD |
PMID:17433394 |
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NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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G |
Tp53 |
tumor protein p53 |
affects response to substance multiple interactions decreases expression affects expression affects binding |
ISO |
TP53 protein affects the susceptibility to 4-biphenylamine Acetylcysteine affects the reaction [4-biphenylamine affects the expression of TP53 protein]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BLM mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCA1 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCC3 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCND3 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCNE2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK1 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of FEN1 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of HDAC2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of POLD3 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of PRKDC mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD51 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD54B mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RRM2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC5 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC6 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of CDKN1A mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of LIG4 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of MDM2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of RPA2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of TP53BP1 mRNA] 4-biphenylamine results in decreased expression of TP53 mRNA 4-biphenylamine binds to TP53 gene |
CTD |
PMID:11804609 PMID:12376482 PMID:32905825 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tp53bp1 |
tumor protein p53 binding protein 1 |
multiple interactions increases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of TP53BP1 mRNA] |
CTD |
PMID:32905825 |
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NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
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G |
Tp73 |
tumor protein p73 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of TP73 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
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G |
Trex1 |
three prime repair exonuclease 1 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of TREX1 mRNA |
CTD |
PMID:24857880 |
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NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796
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G |
Ugt1a5 |
UDP glucuronosyltransferase family 1 member A5 |
increases glucuronidation multiple interactions |
ISO |
UGT1A4 protein results in increased glucuronidation of 4-biphenylamine [Alamethicin results in increased activity of UGT1A4 protein] which results in increased glucuronidation of 4-biphenylamine; hecogenin inhibits the reaction [UGT1A4 protein binds to and results in increased glucuronidation of 4-biphenylamine]; UGT1A4 protein binds to and results in increased glucuronidation of 4-biphenylamine |
CTD |
PMID:15840509 PMID:17080401 |
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NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation multiple interactions |
ISO |
UGT1A9 protein results in increased glucuronidation of 4-biphenylamine [Alamethicin results in increased activity of UGT1A9 protein] which affects the glucuronidation of 4-biphenylamine |
CTD |
PMID:15840509 PMID:17080401 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ung |
uracil-DNA glycosylase |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of UNG mRNA |
CTD |
PMID:24857880 |
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NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
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G |
Xrcc2 |
X-ray repair cross complementing 2 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of XRCC2 mRNA |
CTD |
PMID:24857880 |
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NCBI chr 4:9,423,873...9,502,980
Ensembl chr 4:9,423,898...9,442,482
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G |
Xrcc3 |
X-ray repair cross complementing 3 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of XRCC3 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444
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G |
Xrcc5 |
X-ray repair cross complementing 5 |
multiple interactions decreases expression |
ISO |
Propolis inhibits the reaction [4-biphenylamine results in decreased expression of XRCC5 protein]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC5 mRNA] 4-biphenylamine results in decreased expression of XRCC5 mRNA; 4-biphenylamine results in decreased expression of XRCC5 protein |
CTD |
PMID:32905825 PMID:33847444 |
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NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018
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G |
Xrcc6 |
X-ray repair cross complementing 6 |
multiple interactions decreases expression |
ISO |
Propolis inhibits the reaction [4-biphenylamine results in decreased expression of XRCC6 protein]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC6 mRNA] 4-biphenylamine results in decreased expression of XRCC6 mRNA; 4-biphenylamine results in decreased expression of XRCC6 protein |
CTD |
PMID:32905825 PMID:33847444 |
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NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762
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G |
Acly |
ATP citrate lyase |
decreases expression multiple interactions |
ISO |
tetrachloroisophthalonitrile results in decreased expression of ACLY mRNA [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of ACLY mRNA |
CTD |
PMID:33246813 |
|
NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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G |
Acot1 |
acyl-CoA thioesterase 1 |
decreases expression multiple interactions |
ISO |
tetrachloroisophthalonitrile results in decreased expression of ACOT1 mRNA [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of ACOT1 mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
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G |
Acox1 |
acyl-CoA oxidase 1 |
multiple interactions decreases expression |
ISO |
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of ACOX1 mRNA tetrachloroisophthalonitrile results in decreased expression of ACOX1 mRNA |
CTD |
PMID:33246813 |
|
NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
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G |
Acta2 |
actin alpha 2, smooth muscle |
increases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in increased expression of ACTA2 mRNA |
CTD |
PMID:32289622 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
tetrachloroisophthalonitrile binds to and results in increased activity of AHR protein |
CTD |
PMID:14636698 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Angpt4 |
angiopoietin 4 |
multiple interactions |
ISO |
[tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of ANGPT4 mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 3:140,420,389...140,454,213
Ensembl chr 3:140,420,389...140,453,583
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G |
Ano1 |
anoctamin 1 |
increases expression |
ISO |
tetrachloroisophthalonitrile results in increased expression of ANO1 mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
tetrachloroisophthalonitrile results in increased expression of BAX protein |
CTD |
PMID:30586609 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of BCL2 protein |
CTD |
PMID:30586609 |
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NCBI chr13:22,689,783...22,853,920
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G |
Bmp15 |
bone morphogenetic protein 15 |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of BMP15 protein |
CTD |
PMID:30586609 |
|
NCBI chr X:16,169,123...16,174,187
Ensembl chr X:16,169,123...16,174,187
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in increased expression of CCL2 mRNA |
CTD |
PMID:32289622 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
increases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in increased expression of CCL4 mRNA |
CTD |
PMID:32289622 |
|
NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
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G |
Cftr |
CF transmembrane conductance regulator |
decreases expression multiple interactions |
ISO |
tetrachloroisophthalonitrile results in decreased expression of CFTR protein [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of CFTR protein; [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of CFTR mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Col1a1 |
collagen type I alpha 1 chain |
increases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in increased expression of COL1A1 mRNA; tetrachloroisophthalonitrile metabolite results in increased expression of COL1A1 protein |
CTD |
PMID:32289622 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
decreases expression multiple interactions |
ISO |
tetrachloroisophthalonitrile results in decreased expression of CPT1A mRNA [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of CPT1A mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
increases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in increased expression of CXCL2 mRNA |
CTD |
PMID:32289622 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of CYP11A1 protein |
CTD |
PMID:30586609 |
|
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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G |
Defa10 |
defensin alpha 10 |
multiple interactions |
ISO |
[tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of DEFA3 mRNA |
CTD |
PMID:33246813 |
|
NCBI chr16:70,514,248...70,515,024
Ensembl chr16:70,514,248...70,515,024
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G |
Dgat1 |
diacylglycerol O-acyltransferase 1 |
multiple interactions decreases expression |
ISO |
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of DGAT1 mRNA tetrachloroisophthalonitrile results in decreased expression of DGAT1 mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
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G |
Dgat2 |
diacylglycerol O-acyltransferase 2 |
decreases expression multiple interactions |
ISO |
tetrachloroisophthalonitrile results in decreased expression of DGAT2 mRNA [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of DGAT2 mRNA |
CTD |
PMID:33246813 |
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NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
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G |
Dio1 |
iodothyronine deiodinase 1 |
decreases activity |
ISO |
tetrachloroisophthalonitrile results in decreased activity of DIO1 protein |
CTD |
PMID:29228274 PMID:30561685 |
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NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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G |
Dio2 |
iodothyronine deiodinase 2 |
decreases activity |
ISO |
tetrachloroisophthalonitrile results in decreased activity of DIO2 protein |
CTD |
PMID:30561685 |
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NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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G |
Dio3 |
iodothyronine deiodinase 3 |
decreases activity |
ISO |
tetrachloroisophthalonitrile results in decreased activity of DIO3 protein |
CTD |
PMID:30561685 |
|
NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
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G |
Egfr |
epidermal growth factor receptor |
decreases phosphorylation |
ISO |
tetrachloroisophthalonitrile results in decreased phosphorylation of EGFR protein |
CTD |
PMID:28426875 |
|
NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
increases activity |
ISO |
tetrachloroisophthalonitrile results in increased activity of ERBB2 protein |
CTD |
PMID:11222871 |
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NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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G |
Fabp1 |
fatty acid binding protein 1 |
decreases expression multiple interactions |
ISO |
tetrachloroisophthalonitrile results in decreased expression of FABP1 mRNA [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of FABP1 mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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G |
Fasn |
fatty acid synthase |
decreases expression multiple interactions |
ISO |
tetrachloroisophthalonitrile results in decreased expression of FASN mRNA [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of FASN mRNA |
CTD |
PMID:33246813 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fshr |
follicle stimulating hormone receptor |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of FSHR protein |
CTD |
PMID:30586609 |
|
NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
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G |
Gck |
glucokinase |
multiple interactions decreases expression |
ISO |
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of GCK mRNA tetrachloroisophthalonitrile results in decreased expression of GCK mRNA |
CTD |
PMID:33246813 |
|
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
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G |
Gdf9 |
growth differentiation factor 9 |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of GDF9 protein |
CTD |
PMID:30586609 |
|
NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672
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G |
Gja1 |
gap junction protein, alpha 1 |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of GJA1 protein |
CTD |
PMID:30586609 |
|
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
multiple interactions decreases expression |
ISO |
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of GPAM mRNA tetrachloroisophthalonitrile results in decreased expression of GPAM mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
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G |
Hsd17b4 |
hydroxysteroid (17-beta) dehydrogenase 4 |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of HSD17B4 protein |
CTD |
PMID:30586609 |
|
NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of HSD3B1 protein |
CTD |
PMID:30586609 |
|
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Il1a |
interleukin 1 alpha |
increases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in increased expression of IL1A mRNA |
CTD |
PMID:32289622 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
increases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in increased expression of IL1B mRNA |
CTD |
PMID:32289622 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
increases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in increased expression of IL6 mRNA |
CTD |
PMID:32289622 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Klf4 |
Kruppel like factor 4 |
multiple interactions increases expression |
ISO |
[tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of KLF4 mRNA tetrachloroisophthalonitrile results in increased expression of KLF4 mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation |
ISO |
tetrachloroisophthalonitrile results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:28426875 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation |
ISO |
tetrachloroisophthalonitrile results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:28426875 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mep1b |
meprin A subunit beta |
multiple interactions increases expression |
ISO |
[tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of MEP1B mRNA tetrachloroisophthalonitrile results in increased expression of MEP1B mRNA |
CTD |
PMID:33246813 |
|
NCBI chr18:12,366,126...12,392,840
Ensembl chr18:12,365,289...12,392,840
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G |
Mif |
macrophage migration inhibitory factor |
decreases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in decreased expression of MIF mRNA |
CTD |
PMID:32289622 |
|
NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
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G |
Mlxip |
MLX interacting protein |
multiple interactions |
ISO |
[procymidone co-treated with tetrachloroisophthalonitrile] results in increased expression of MLXIP mRNA |
CTD |
PMID:33246813 |
|
NCBI chr12:33,128,524...33,192,300
Ensembl chr12:33,128,520...33,192,374
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G |
Mmp1 |
matrix metallopeptidase 1 |
decreases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in decreased expression of MMP1 mRNA |
CTD |
PMID:32289622 |
|
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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G |
Mmp3 |
matrix metallopeptidase 3 |
decreases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in decreased expression of MMP3 mRNA |
CTD |
PMID:32289622 |
|
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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G |
Mmp9 |
matrix metallopeptidase 9 |
increases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in increased expression of MMP9 mRNA |
CTD |
PMID:32289622 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mttp |
microsomal triglyceride transfer protein |
multiple interactions |
ISO |
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of MTTP mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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G |
Muc1 |
mucin 1, cell surface associated |
increases expression |
ISO |
tetrachloroisophthalonitrile results in increased expression of MUC1 mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 2:174,635,559...174,640,738
Ensembl chr 2:174,635,995...174,640,733
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G |
Muc2 |
mucin 2, oligomeric mucus/gel-forming |
increases expression decreases expression multiple interactions |
ISO |
tetrachloroisophthalonitrile results in increased expression of MUC2 mRNA tetrachloroisophthalonitrile results in decreased expression of MUC2 protein [tetrachloroisophthalonitrile co-treated with procymidone] results in decreased expression of MUC2 protein |
CTD |
PMID:33246813 |
|
NCBI chr 1:196,796,257...196,831,740
Ensembl chr 1:196,799,517...196,831,756
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G |
Muc3 |
mucin 3 |
multiple interactions |
ISO |
[tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of MUC3 mRNA |
CTD |
PMID:33246813 |
|
NCBI chr12:19,527,251...19,536,924
Ensembl chr12:19,527,321...19,538,522
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity |
ISO |
tetrachloroisophthalonitrile results in increased activity of NR1I2 protein |
CTD |
PMID:20143881 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Pklr |
pyruvate kinase L/R |
decreases expression multiple interactions |
ISO |
tetrachloroisophthalonitrile results in decreased expression of PKLR mRNA [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of PKLR mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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G |
Pla2g4a |
phospholipase A2 group IVA |
multiple interactions |
ISO |
[tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of PLA2G4A mRNA |
CTD |
PMID:33246813 |
|
NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
decreases expression multiple interactions |
ISO |
tetrachloroisophthalonitrile results in decreased expression of PPARA mRNA [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of PPARA mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases expression multiple interactions |
ISO |
tetrachloroisophthalonitrile results in decreased expression of PPARG mRNA [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of PPARG mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in increased expression of PTGS2 mRNA |
CTD |
PMID:32289622 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Rad51 |
RAD51 recombinase |
increases expression |
ISO |
tetrachloroisophthalonitrile results in increased expression of RAD51 protein |
CTD |
PMID:30586609 |
|
NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
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|
G |
S100a8 |
S100 calcium binding protein A8 |
increases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in increased expression of S100A8 mRNA |
CTD |
PMID:32289622 |
|
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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G |
S100a9 |
S100 calcium binding protein A9 |
decreases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in decreased expression of S100A9 mRNA |
CTD |
PMID:32289622 |
|
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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G |
Scd |
stearoyl-CoA desaturase |
multiple interactions decreases expression |
ISO |
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of SCD1 mRNA tetrachloroisophthalonitrile results in decreased expression of SCD1 mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Slc12a2 |
solute carrier family 12 member 2 |
multiple interactions |
ISO |
[tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of SLC12A2 mRNA |
CTD |
PMID:33246813 |
|
NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
|
|
G |
Slc26a3 |
solute carrier family 26 member 3 |
multiple interactions increases expression |
ISO |
[tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of SLC26A3 mRNA tetrachloroisophthalonitrile results in increased expression of SLC26A3 mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772
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G |
Slc26a6 |
solute carrier family 26 member 6 |
increases expression |
ISO |
tetrachloroisophthalonitrile results in increased expression of SLC26A6 mRNA |
CTD |
PMID:33246813 |
|
NCBI chr 8:109,558,968...109,569,778
Ensembl chr 8:109,559,642...109,569,778
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G |
Slc27a2 |
solute carrier family 27 member 2 |
decreases expression multiple interactions |
ISO |
tetrachloroisophthalonitrile results in decreased expression of SLC27A2 mRNA [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of SLC27A2 mRNA |
CTD |
PMID:33246813 |
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NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
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G |
Slc9a3 |
solute carrier family 9 member A3 |
multiple interactions increases expression |
ISO |
[tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of SLC9A3 mRNA tetrachloroisophthalonitrile results in increased expression of SLC9A3 mRNA |
CTD |
PMID:33246813 |
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NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417
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G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases activity |
ISO |
tetrachloroisophthalonitrile results in decreased activity of TGFB1 protein |
CTD |
PMID:31652400 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tlr4 |
toll-like receptor 4 |
increases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in increased expression of TLR4 mRNA |
CTD |
PMID:32289622 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
increases expression |
ISO |
tetrachloroisophthalonitrile metabolite results in increased expression of TNF mRNA |
CTD |
PMID:32289622 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
ISO |
croneton inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] |
CTD |
PMID:26647222 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Ache |
acetylcholinesterase |
decreases activity multiple interactions |
ISO EXP |
fenamiphos results in decreased activity of ACHE protein fenamiphos binds to and results in increased phosphorylation of and results in decreased activity of ACHE protein |
CTD |
PMID:17382909 PMID:17402711 PMID:33720374 |
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NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
fenamiphos inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] |
CTD |
PMID:33049310 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
fenamiphos binds to and results in increased activity of ESR1 protein |
CTD |
PMID:33049310 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
ISO |
fenamiphos binds to and results in increased activity of ESR2 protein |
CTD |
PMID:33049310 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions affects activity |
ISO |
fenamiphos binds to and results in increased activity of NR1I2 protein fenamiphos affects the activity of NR1I2 protein |
CTD |
PMID:21115097 PMID:23611293 PMID:33049310 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
fenamiphos binds to and results in increased activity of PPARG protein |
CTD |
PMID:33049310 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases response to substance |
ISO |
ABCC1 protein results in decreased susceptibility to Fenitrothion |
CTD |
PMID:12765240 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Ache |
acetylcholinesterase |
decreases activity decreases expression multiple interactions |
ISO EXP |
Fenitrothion results in decreased activity of ACHE protein Fenitrothion results in decreased expression of ACHE protein Acetylcysteine inhibits the reaction [Fenitrothion results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of ACHE protein]; Quercetin inhibits the reaction [Fenitrothion results in decreased activity of ACHE protein] |
CTD |
PMID:2086312 PMID:6933967 PMID:30639957 PMID:31173782 PMID:32034696 |
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NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Ar |
androgen receptor |
multiple interactions decreases activity increases expression affects binding |
ISO |
Dihydrotestosterone inhibits the reaction [Fenitrothion results in increased activity of AR protein]; Fenitrothion analog binds to and results in decreased activity of AR protein; Fenitrothion inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Fenitrothion inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Fenitrothion inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Fenitrothion inhibits the reaction [Metribolone results in increased activity of AR protein] Fenitrothion results in decreased activity of AR protein Fenitrothion results in increased expression of AR mRNA Fenitrothion binds to AR protein |
CTD |
PMID:11222873 PMID:12676613 PMID:15064155 PMID:15253041 PMID:18324785 PMID:21251949 PMID:21310686 PMID:33049310 More...
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
EXP |
Fenitrothion results in increased expression of BAX mRNA; Fenitrothion results in increased expression of BAX protein Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of BAX mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of BAX mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of BAX mRNA]]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of BAX protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of BAX mRNA] |
CTD |
PMID:31173782 PMID:32034696 PMID:32572764 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression decreases expression multiple interactions |
ISO EXP |
Fenitrothion results in increased expression of BCL2 mRNA Fenitrothion results in decreased expression of BCL2 mRNA Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]; Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of BCL2 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of BCL2 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of BCL2 mRNA] |
CTD |
PMID:21298709 PMID:31173782 PMID:32572764 |
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NCBI chr13:22,689,783...22,853,920
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G |
Casp3 |
caspase 3 |
increases expression multiple interactions |
EXP |
Fenitrothion results in increased expression of CASP3 mRNA; Fenitrothion results in increased expression of CASP3 protein [Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of CASP3 protein]; Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CASP3 mRNA]; Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of CASP3 mRNA]; Plant Preparations inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CASP3 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in increased expression of CASP3 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA]]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of CASP3 mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of CASP3 protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in increased expression of CASP3 mRNA] |
CTD |
PMID:31173782 PMID:32034696 PMID:32572764 PMID:33393722 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions increases expression |
EXP |
[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of CASP9 mRNA]; Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CASP9 mRNA]; Plant Preparations inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of CASP9 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CASP9 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of CASP9 mRNA] |
CTD |
PMID:33393722 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions increases activity decreases activity decreases expression |
EXP |
[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in decreased activity of CAT protein]; Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased activity of CAT protein]; Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of CAT protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of CAT protein]]; Plant Preparations inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in decreased activity of CAT protein]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased activity of CAT protein]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased activity of CAT protein]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of CAT protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of CAT protein]; Quercetin inhibits the reaction [Fenitrothion results in decreased expression of CAT mRNA]; Quercetin inhibits the reaction [Fenitrothion results in increased activity of CAT protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of CAT protein] Fenitrothion results in decreased expression of CAT mRNA; Fenitrothion results in decreased expression of CAT protein |
CTD |
PMID:26264430 PMID:30578656 PMID:32034696 PMID:32572764 PMID:33393722 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cd68 |
Cd68 molecule |
increases expression multiple interactions |
EXP |
Fenitrothion results in increased expression of CD68 protein [Fenitrothion co-treated with Potassium Dichromate] results in increased expression of CD68 protein; Plant Extracts inhibits the reaction [[Fenitrothion co-treated with Potassium Dichromate] results in increased expression of CD68 protein]; Plant Extracts inhibits the reaction [Fenitrothion results in increased expression of CD68 protein] |
CTD |
PMID:30578656 |
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NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression multiple interactions |
EXP |
Fenitrothion results in increased expression of CDKN1A mRNA [Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of CDKN1A mRNA]; Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CDKN1A mRNA]; Plant Preparations inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of CDKN1A mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CDKN1A mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of CDKN1A mRNA] |
CTD |
PMID:33393722 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity multiple interactions increases expression |
ISO EXP |
Fenitrothion results in decreased activity of CYP1A1 protein Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:15620088 PMID:20183062 PMID:21298709 PMID:30639957 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression decreases activity |
ISO |
Fenitrothion results in increased expression of CYP1A2 mRNA Fenitrothion results in decreased activity of CYP1A2 protein |
CTD |
PMID:20183062 PMID:22310298 PMID:22634058 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases expression decreases activity multiple interactions |
ISO |
Fenitrothion results in increased expression of CYP2B6 mRNA Fenitrothion results in decreased activity of CYP2B6 protein Fenitrothion inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion] |
CTD |
PMID:20183062 PMID:22310298 PMID:22634058 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity |
ISO |
Fenitrothion results in decreased activity of CYP2C8 protein |
CTD |
PMID:20183062 |
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions decreases activity |
ISO |
Fenitrothion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone] Fenitrothion results in decreased activity of CYP2E1 protein |
CTD |
PMID:22634058 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity multiple interactions increases activity increases expression |
ISO |
Fenitrothion results in decreased activity of CYP3A4 protein [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA Fenitrothion results in increased activity of CYP3A4 protein Fenitrothion results in increased expression of CYP3A4 mRNA |
CTD |
PMID:17293382 PMID:20183062 PMID:22310298 PMID:25028461 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
Fenitrothion binds to and results in increased activity of ESR1 protein |
CTD |
PMID:33049310 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
ISO |
Fenitrothion binds to and results in increased activity of ESR2 protein |
CTD |
PMID:33049310 |
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Faah |
fatty acid amide hydrolase |
decreases activity |
ISO |
Fenitrothion results in decreased activity of FAAH protein |
CTD |
PMID:24361246 |
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NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions increases secretion |
EXP |
Fenitrothion promotes the reaction [Potassium Dichromate results in increased secretion of FSHB protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in increased secretion of FSHB protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in increased secretion of FSHB protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in increased secretion of FSHB protein]]; Potassium Dichromate promotes the reaction [Fenitrothion results in increased secretion of FSHB protein] |
CTD |
PMID:30578656 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions increases expression |
EXP |
Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of GFAP protein] |
CTD |
PMID:31173782 |
|
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions increases activity decreases activity decreases expression |
EXP |
[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased activity of GSR protein]; Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased activity of GSR protein]; Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of GSR protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of GSR protein]]; Plant Extracts inhibits the reaction [Fenitrothion results in decreased expression of GSR protein]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of GSR protein]]; Plant Preparations inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased activity of GSR protein]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased activity of GSR protein]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased activity of GSR protein]; Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of GSR protein] Fenitrothion results in decreased activity of GSR protein |
CTD |
PMID:30578656 PMID:32034696 PMID:33393722 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gsta4 |
glutathione S-transferase alpha 4 |
multiple interactions decreases expression |
EXP |
Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of GSTA4 mRNA] |
CTD |
PMID:30639957 |
|
NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
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G |
Hsd17b3 |
hydroxysteroid (17-beta) dehydrogenase 3 |
multiple interactions decreases expression |
EXP |
Quercetin inhibits the reaction [Fenitrothion results in decreased expression of HSD17B3 mRNA] |
CTD |
PMID:26264430 |
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NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
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G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
multiple interactions decreases expression |
EXP |
Quercetin inhibits the reaction [Fenitrothion results in decreased expression of HSD3B2 mRNA] |
CTD |
PMID:26264430 |
|
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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G |
Ifng |
interferon gamma |
decreases expression |
ISO |
Fenitrothion results in decreased expression of IFNG protein |
CTD |
PMID:12108020 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
EXP |
Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of IL1B protein] |
CTD |
PMID:30639957 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2 |
interleukin 2 |
decreases expression increases secretion multiple interactions |
ISO EXP |
Fenitrothion results in decreased expression of IL2 protein Fenitrothion results in increased secretion of IL2 protein Acetylcysteine inhibits the reaction [Fenitrothion results in increased secretion of IL2 protein] |
CTD |
PMID:12108020 PMID:31173782 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Lcat |
lecithin cholesterol acyltransferase |
multiple interactions decreases activity |
ISO |
Fenitrothion inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters] Fenitrothion results in decreased activity of LCAT protein |
CTD |
PMID:4847537 |
|
NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
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G |
Lhb |
luteinizing hormone subunit beta |
decreases secretion multiple interactions |
EXP |
Fenitrothion results in decreased secretion of LHB protein Quercetin inhibits the reaction [Fenitrothion results in decreased secretion of LHB protein] |
CTD |
PMID:26264430 |
|
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Mgll |
monoglyceride lipase |
decreases activity |
ISO |
Fenitrothion analog results in decreased activity of MGLL protein |
CTD |
PMID:16449251 |
|
NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179
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G |
Nceh1 |
neutral cholesterol ester hydrolase 1 |
decreases activity |
ISO |
Fenitrothion analog results in decreased activity of NCEH1 protein |
CTD |
PMID:16449251 |
|
NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
[N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased activity of NR1I2 protein; Fenitrothion binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:25028461 PMID:33049310 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr5a1 |
nuclear receptor subfamily 5, group A, member 1 |
decreases expression multiple interactions |
EXP |
Fenitrothion results in decreased expression of NR5A1 mRNA Quercetin inhibits the reaction [Fenitrothion results in decreased expression of NR5A1 mRNA] |
CTD |
PMID:26264430 |
|
NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328
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G |
Pla2g3 |
phospholipase A2, group III |
decreases expression |
EXP |
Fenitrothion results in decreased expression of PLA2G3 protein |
CTD |
PMID:29292090 |
|
NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913
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G |
Pon1 |
paraoxonase 1 |
multiple interactions decreases expression decreases activity |
EXP |
Fenitrothion promotes the reaction [Vehicle Emissions results in decreased activity of PON1 protein]; Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of PON1 mRNA]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased activity of PON1 protein]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [Vehicle Emissions results in decreased expression of PON1 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased activity of PON1 protein]; Plant Preparations inhibits the reaction [Fenitrothion results in decreased expression of PON1 mRNA]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of PON1 protein]]; Plant Preparations inhibits the reaction [Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of PON1 mRNA]]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased activity of PON1 protein]; Vehicle Emissions promotes the reaction [Fenitrothion results in decreased expression of PON1 mRNA] |
CTD |
PMID:32572764 |
|
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
Fenitrothion binds to and results in increased activity of PPARG protein |
CTD |
PMID:33049310 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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|
G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Fenitrothion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:23770354 |
|
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
|
|
G |
Slc22a6 |
solute carrier family 22 member 6 |
multiple interactions |
ISO |
Fenitrothion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] |
CTD |
PMID:21561794 |
|
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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G |
Sod1 |
superoxide dismutase 1 |
decreases expression multiple interactions |
EXP |
Fenitrothion results in decreased expression of SOD1 mRNA Quercetin inhibits the reaction [Fenitrothion results in decreased expression of SOD1 mRNA] |
CTD |
PMID:26264430 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Thra |
thyroid hormone receptor alpha |
multiple interactions |
ISO |
Fenitrothion binds to and results in increased activity of THRA protein |
CTD |
PMID:33049310 |
|
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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|
G |
Thrb |
thyroid hormone receptor beta |
multiple interactions |
ISO |
Fenitrothion binds to and results in increased activity of THRB protein |
CTD |
PMID:33049310 |
|
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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|
G |
Tnf |
tumor necrosis factor |
multiple interactions increases secretion increases expression |
EXP |
Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased secretion of TNF protein] |
CTD |
PMID:30639957 PMID:31173782 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
EXP |
[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of TP53 mRNA]; Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TP53 mRNA]; Plant Preparations inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [Fenitrothion results in increased expression of TP53 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TP53 mRNA]]; Plant Preparations inhibits the reaction [Fenitrothion results in increased expression of TP53 mRNA] |
CTD |
PMID:31173782 PMID:33393722 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Ache |
acetylcholinesterase |
decreases activity |
ISO EXP |
Fenthion results in decreased activity of ACHE protein |
CTD |
PMID:1855619 PMID:14976351 |
|
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Dihydrotestosterone inhibits the reaction [Fenthion results in increased activity of AR protein]; Fenthion inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Fenthion inhibits the reaction [Metribolone results in increased activity of AR protein] |
CTD |
PMID:15064155 PMID:18324785 PMID:33049310 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Bche |
butyrylcholinesterase |
decreases activity |
ISO |
Fenthion results in decreased activity of BCHE protein |
CTD |
PMID:24052565 |
|
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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G |
Brca1 |
BRCA1, DNA repair associated |
decreases expression |
ISO |
Fenthion results in decreased expression of BRCA1 mRNA |
CTD |
PMID:33221015 |
|
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
affects metabolic processing |
ISO |
CYP3A4 protein affects the metabolism of Fenthion |
CTD |
PMID:17110060 |
|
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
affects metabolic processing |
ISO |
CYP3A5 protein affects the metabolism of Fenthion |
CTD |
PMID:17110060 |
|
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Dio1 |
iodothyronine deiodinase 1 |
decreases activity |
ISO |
Fenthion results in decreased activity of DIO1 protein |
CTD |
PMID:29228274 |
|
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
Fenthion binds to and results in increased activity of ESR1 protein |
CTD |
PMID:33049310 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
ISO |
Fenthion binds to and results in increased activity of ESR2 protein |
CTD |
PMID:33049310 |
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Esrrg |
estrogen-related receptor gamma |
increases activity |
ISO |
Fenthion results in increased activity of ESRRG protein |
CTD |
PMID:20143881 |
|
NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397
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G |
Fmo1 |
flavin containing dimethylaniline monoxygenase 1 |
increases oxidation |
ISO |
FMO1 protein results in increased oxidation of Fenthion |
CTD |
PMID:14976351 |
|
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Fenthion results in increased expression of FOS mRNA |
CTD |
PMID:21538558 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO |
Fenthion results in increased expression of GADD45A mRNA |
CTD |
PMID:21538558 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
H2ax |
H2A.X variant histone |
increases expression |
ISO |
Fenthion results in increased expression of H2AX protein |
CTD |
PMID:33221015 |
|
NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
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G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
increases expression |
EXP |
Fenthion results in increased expression of HSP90AA1 mRNA alternative form |
CTD |
PMID:8792849 |
|
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Fenthion results in increased expression of JUN mRNA |
CTD |
PMID:21538558 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
ISO |
Fenthion results in increased expression of MYC mRNA |
CTD |
PMID:21538558 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
Fenthion binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:33049310 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
increases expression |
ISO |
Fenthion results in increased expression of NR4A1 |
CTD |
PMID:21538558 |
|
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression multiple interactions |
ISO |
Fenthion results in increased expression of PPARG mRNA Fenthion binds to and results in increased activity of PPARG protein |
CTD |
PMID:32473317 PMID:33049310 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
increases expression |
ISO |
Fenthion results in increased expression of PPP1R15A mRNA |
CTD |
PMID:21538558 |
|
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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G |
Rad18 |
RAD18 E3 ubiquitin protein ligase |
multiple interactions decreases expression |
ISO |
[terbufos co-treated with Fenthion] results in increased expression of RAD18 mRNA Fenthion results in decreased expression of RAD18 mRNA |
CTD |
PMID:33221015 |
|
NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069
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G |
Rad51 |
RAD51 recombinase |
decreases expression multiple interactions |
ISO |
Fenthion results in decreased expression of RAD51 mRNA; Fenthion results in decreased expression of RAD51 protein Fenthion inhibits the reaction [terbufos results in decreased expression of RAD51 protein]; terbufos inhibits the reaction [Fenthion results in decreased expression of RAD51 protein] |
CTD |
PMID:33221015 |
|
NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
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G |
Socs3 |
suppressor of cytokine signaling 3 |
increases expression |
ISO |
Fenthion results in increased expression of SOCS3 mRNA |
CTD |
PMID:21538558 |
|
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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G |
Tnfaip3 |
TNF alpha induced protein 3 |
increases expression |
ISO |
Fenthion results in increased expression of TNFAIP3 mRNA |
CTD |
PMID:21538558 |
|
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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G |
Xrcc2 |
X-ray repair cross complementing 2 |
decreases expression multiple interactions |
ISO |
Fenthion results in decreased expression of XRCC2 mRNA; Fenthion results in decreased expression of XRCC2 protein [terbufos co-treated with Fenthion] results in increased expression of XRCC2 mRNA |
CTD |
PMID:33221015 |
|
NCBI chr 4:9,423,873...9,502,980
Ensembl chr 4:9,423,898...9,442,482
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G |
Xrcc6 |
X-ray repair cross complementing 6 |
increases expression multiple interactions |
ISO |
Fenthion results in increased expression of XRCC6 mRNA [terbufos co-treated with Fenthion] results in decreased expression of XRCC6 mRNA; [terbufos co-treated with Fenthion] results in decreased expression of XRCC6 protein |
CTD |
PMID:33221015 |
|
NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762
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G |
Acta1 |
actin, alpha 1, skeletal muscle |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of ACTA1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
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G |
Akr1b7 |
aldo-keto reductase family 1, member B7 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of AKR1B7 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502
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G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
decreases activity |
ISO |
Flurbiprofen results in decreased activity of AKR1C1 protein |
CTD |
PMID:19010312 |
|
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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G |
Akr1c2 |
aldo-keto reductase family 1, member C2 |
decreases activity |
ISO |
Flurbiprofen results in decreased activity of AKR1C2 protein |
CTD |
PMID:19010312 |
|
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
multiple interactions decreases activity |
ISO |
[Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased chemical synthesis of farnesoic acid; [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol |
CTD |
PMID:19010312 PMID:21187079 |
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NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
[Flurbiprofen results in increased phosphorylation of and results in increased activity of PSCA protein] which results in increased expression of AKT1 protein; Akt-I-1,2 compound inhibits the reaction [Flurbiprofen results in increased phosphorylation of and results in increased activity of AKT1 protein]; AKT1 protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]; Flurbiprofen results in increased phosphorylation of and results in increased activity of AKT1 protein |
CTD |
PMID:16949054 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alb |
albumin |
affects binding |
ISO |
Flurbiprofen binds to ALB protein |
CTD |
PMID:9353694 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Aldh7a1 |
aldehyde dehydrogenase 7 family, member A1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of ALDH7A1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
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G |
Anp32a |
acidic nuclear phosphoprotein 32 family member A |
increases expression |
ISO |
Flurbiprofen results in increased expression of ANP32A mRNA |
CTD |
PMID:16949054 |
|
Ensembl chr 8:62,827,456...62,865,443
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G |
Anxa1 |
annexin A1 |
increases expression |
ISO |
Flurbiprofen results in increased expression of ANXA1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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G |
Anxa3 |
annexin A3 |
increases expression |
ISO |
Flurbiprofen results in increased expression of ANXA3 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
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G |
Apod |
apolipoprotein D |
increases expression |
ISO |
Flurbiprofen results in increased expression of APOD mRNA |
CTD |
PMID:16949054 |
|
NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
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G |
Apof |
apolipoprotein F |
increases expression |
ISO |
Flurbiprofen results in increased expression of APOF mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946
|
|
G |
App |
amyloid beta precursor protein |
affects cleavage decreases secretion multiple interactions |
ISO EXP |
Flurbiprofen affects the cleavage of APP protein Flurbiprofen results in decreased secretion of APP protein alitretinoin inhibits the reaction [Flurbiprofen results in decreased secretion of APP protein]; Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein]; RXRA protein promotes the reaction [Flurbiprofen results in decreased secretion of APP protein] Flurbiprofen inhibits the reaction [APP protein results in increased uptake of Calcium] |
CTD |
PMID:14690522 PMID:17292621 PMID:18648507 PMID:19659691 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Arg1 |
arginase 1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of ARG1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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G |
Asic1 |
acid sensing ion channel subunit 1 |
decreases activity |
EXP |
Flurbiprofen results in decreased activity of ASIC1 protein |
CTD |
PMID:11588175 |
|
NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
increases expression |
ISO |
Flurbiprofen results in increased expression of BIRC5 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Bnip3 |
BCL2 interacting protein 3 |
increases expression |
ISO |
Flurbiprofen results in increased expression of BNIP3 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions |
EXP |
Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]]; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [CALCA protein results in increased susceptibility to Nitroprusside]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein] |
CTD |
PMID:8581270 PMID:11166334 PMID:12044622 PMID:12791437 PMID:14991081 |
|
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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|
G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of CCNB1 protein |
CTD |
PMID:11687965 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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|
G |
Ceacam1 |
CEA cell adhesion molecule 1 |
increases expression |
ISO |
Flurbiprofen results in increased expression of CEACAM1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
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G |
Ces3a |
carboxylesterase 3a |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of CES3 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr19:32,992,386...33,000,562
|
|
G |
Cited2 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
increases expression |
ISO |
Flurbiprofen results in increased expression of CITED2 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
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|
G |
Cmas |
cytidine monophosphate N-acetylneuraminic acid synthetase |
increases expression |
ISO |
Flurbiprofen results in increased expression of CMAS mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 4:175,718,808...175,737,128
Ensembl chr 4:175,718,808...175,737,125
|
|
G |
Cmpk2 |
cytidine/uridine monophosphate kinase 2 |
increases expression |
ISO |
Flurbiprofen results in increased expression of CMPK2 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183
|
|
G |
Crisp1 |
cysteine-rich secretory protein 1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of CRISP1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 9:20,741,775...20,768,796
Ensembl chr 9:20,741,777...20,768,796
|
|
G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases activity |
ISO EXP |
Flurbiprofen results in decreased activity of CYP17A1 protein |
CTD |
PMID:31184881 |
|
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
|
|
G |
Cyp24a1 |
cytochrome P450, family 24, subfamily a, polypeptide 1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of CYP24A1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
|
|
G |
Cyp2f4 |
cytochrome P450, family 2, subfamily f, polypeptide 4 |
increases expression |
ISO |
Flurbiprofen results in increased expression of CYP2F2 mRNA |
CTD |
PMID:16949054 |
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NCBI chr 1:82,416,108...82,429,897
Ensembl chr 1:82,416,130...82,429,896
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G |
Defb1 |
defensin beta 1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of DEFB1 mRNA |
CTD |
PMID:16949054 |
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NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604
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G |
Egf |
epidermal growth factor |
increases expression |
ISO |
Flurbiprofen results in increased expression of EGF mRNA |
CTD |
PMID:16949054 |
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NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
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G |
Eif4e |
eukaryotic translation initiation factor 4E |
increases phosphorylation multiple interactions |
ISO |
Flurbiprofen results in increased phosphorylation of EIF4E protein MAPK14 protein promotes the reaction [Flurbiprofen results in increased phosphorylation of EIF4E protein] |
CTD |
PMID:18056468 |
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NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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G |
Elavl1 |
ELAV like RNA binding protein 1 |
multiple interactions increases expression |
ISO |
ELAVL1 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; Flurbiprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA] Flurbiprofen results in increased expression of ELAVL1 protein |
CTD |
PMID:18056468 |
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NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
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Eln |
elastin |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of ELN mRNA |
CTD |
PMID:16949054 |
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NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
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G |
Enpp2 |
ectonucleotide pyrophosphatase/phosphodiesterase 2 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of ENPP2 mRNA |
CTD |
PMID:16949054 |
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NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
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G |
Faah |
fatty acid amide hydrolase |
decreases activity |
EXP |
Flurbiprofen results in decreased activity of FAAH protein |
CTD |
PMID:12751821 |
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NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
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G |
Folr1 |
folate receptor alpha |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of FOLR1 mRNA |
CTD |
PMID:16949054 |
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NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP ISO |
Flurbiprofen inhibits the reaction [Carrageenan results in increased expression of FOS protein]; Flurbiprofen promotes the reaction [Urethane inhibits the reaction [Carrageenan results in increased expression of FOS protein]]; Urethane inhibits the reaction [Flurbiprofen inhibits the reaction [Carrageenan results in increased expression of FOS protein]] Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of FOS mRNA] |
CTD |
PMID:10864209 PMID:11164833 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression multiple interactions |
ISO |
Flurbiprofen results in increased expression of GDF15 protein 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]; NGFR protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein] |
CTD |
PMID:21097678 |
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NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
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G |
Gpx3 |
glutathione peroxidase 3 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of GPX3 mRNA |
CTD |
PMID:16949054 |
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NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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G |
Gsto1 |
glutathione S-transferase omega 1 |
increases expression |
ISO |
Flurbiprofen results in increased expression of GSTO1 mRNA |
CTD |
PMID:16949054 |
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NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
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G |
Gusb |
glucuronidase, beta |
multiple interactions |
ISO |
Flurbiprofen inhibits the reaction [Misonidazole results in increased activity of GUSB protein] |
CTD |
PMID:6696821 |
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NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905
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G |
Hells |
helicase, lymphoid specific |
increases expression |
ISO |
Flurbiprofen results in increased expression of HELLS mRNA |
CTD |
PMID:16949054 |
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NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
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G |
Hpgd |
15-hydroxyprostaglandin dehydrogenase |
decreases degradation increases expression multiple interactions increases activity |
ISO |
Flurbiprofen results in decreased degradation of HPGD protein Flurbiprofen results in increased expression of HPGD mRNA [[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein Flurbiprofen results in increased activity of HPGD protein |
CTD |
PMID:19501039 |
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NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
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G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
HRAS protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA] |
CTD |
PMID:16949054 |
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NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
increases expression |
ISO |
Flurbiprofen results in increased expression of HSD11B2 mRNA |
CTD |
PMID:16949054 |
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NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
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G |
Icam1 |
intercellular adhesion molecule 1 |
increases expression |
EXP |
Flurbiprofen results in increased expression of ICAM1 protein |
CTD |
PMID:16020654 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifit2 |
interferon-induced protein with tetratricopeptide repeats 2 |
increases expression |
ISO |
Flurbiprofen results in increased expression of IFIT2 mRNA |
CTD |
PMID:16949054 |
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NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein] |
CTD |
PMID:19659691 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
Flurbiprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] |
CTD |
PMID:10903797 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il11 |
interleukin 11 |
multiple interactions |
ISO |
Flurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Calcium]; Flurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Dinoprostone] |
CTD |
PMID:12110441 |
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NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA] Flurbiprofen results in increased expression of [IL1B protein results in increased expression of PTGS2 protein] |
CTD |
PMID:11112151 PMID:12517972 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Flurbiprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:10903797 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Kcnn4 |
potassium calcium-activated channel subfamily N member 4 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of KCNN4 mRNA |
CTD |
PMID:16949054 |
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NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
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G |
Kng2 |
kininogen 2 |
multiple interactions |
EXP |
Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]] |
CTD |
PMID:11166334 PMID:12791437 |
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NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
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G |
Lgals3 |
galectin 3 |
increases expression |
ISO |
Flurbiprofen results in increased expression of LGALS3 mRNA |
CTD |
PMID:16949054 |
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NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
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G |
Lgals9 |
galectin 9 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of LGALS9 mRNA |
CTD |
PMID:16949054 |
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NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Androstane-3,17-diol]; Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Testosterone] |
CTD |
PMID:31184881 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Lhcgr |
luteinizing hormone/choriogonadotropin receptor |
decreases expression |
EXP |
Flurbiprofen results in decreased expression of LHCGR mRNA; Flurbiprofen results in decreased expression of LHCGR protein |
CTD |
PMID:31184881 |
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NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
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G |
Lmo7 |
LIM domain 7 |
increases expression |
ISO |
Flurbiprofen results in increased expression of LMO7 mRNA |
CTD |
PMID:16949054 |
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NCBI chr15:78,567,029...78,769,833
Ensembl chr15:78,567,023...78,769,783
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G |
Lto1 |
LTO1 maturation factor of ABCE1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of LTO1 mRNA |
CTD |
PMID:16949054 |
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NCBI chr 1:200,074,247...200,080,951
Ensembl chr 1:200,074,253...200,088,061
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Flurbiprofen results in decreased phosphorylation of and results in decreased activity of MAPK1 protein |
CTD |
PMID:19501039 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk11 |
mitogen-activated protein kinase 11 |
multiple interactions |
ISO |
MAPK11 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] |
CTD |
PMID:18056468 |
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NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased phosphorylation of EIF4E protein] |
CTD |
PMID:18056468 PMID:21097678 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
Flurbiprofen results in decreased phosphorylation of and results in decreased activity of MAPK3 protein |
CTD |
PMID:19501039 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapkapk2 |
MAPK activated protein kinase 2 |
multiple interactions |
ISO |
Flurbiprofen results in increased phosphorylation of and results in increased activity of MAPKAPK2 protein; MAPKAPK2 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] |
CTD |
PMID:18056468 |
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NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
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G |
Mapkapk3 |
MAPK activated protein kinase 3 |
multiple interactions |
ISO |
MAPKAPK3 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] |
CTD |
PMID:18056468 |
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NCBI chr 8:107,929,754...107,963,638
Ensembl chr 8:107,929,762...107,963,568
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
ISO |
[[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein; [Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA Flurbiprofen results in decreased expression of MMP9 mRNA |
CTD |
PMID:19501039 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Msmb |
microseminoprotein, beta |
increases expression |
ISO |
Flurbiprofen results in increased expression of MSMB mRNA |
CTD |
PMID:16949054 |
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NCBI chr16:7,366,536...7,387,124
Ensembl chr16:7,366,536...7,387,123
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:11099482 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbiz |
NFKB inhibitor zeta |
increases expression |
ISO |
Flurbiprofen results in increased expression of NFKBIZ mRNA |
CTD |
PMID:16949054 |
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NCBI chr11:44,782,676...44,810,723
Ensembl chr11:44,782,676...44,810,723
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G |
Ngfr |
nerve growth factor receptor |
multiple interactions increases expression |
ISO |
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of NGFR mRNA]; ELAVL1 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; Flurbiprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]; Flurbiprofen results in increased stability of and results in increased expression of NGFR mRNA; MAPK11 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPKAPK2 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPKAPK3 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; NGFR protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein] Flurbiprofen results in increased expression of NGFR mRNA; Flurbiprofen results in increased expression of NGFR protein |
CTD |
PMID:17409433 PMID:17447067 PMID:18056468 PMID:21097678 |
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NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions increases expression |
EXP ISO |
Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] Flurbiprofen results in increased expression of NOS2 mRNA Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites]; Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] |
CTD |
PMID:8528547 PMID:11405284 PMID:16944022 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases activity |
ISO |
Flurbiprofen results in increased activity of NQO1 protein |
CTD |
PMID:8572925 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Papss2 |
3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
increases expression |
ISO |
Flurbiprofen results in increased expression of PAPSS2 mRNA |
CTD |
PMID:16949054 |
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NCBI chr 1:230,454,314...230,539,332
Ensembl chr 1:230,454,426...230,539,331
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G |
Pcp4 |
Purkinje cell protein 4 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of PCP4 mRNA |
CTD |
PMID:16949054 |
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NCBI chr11:35,759,711...35,861,725
Ensembl chr11:35,800,713...35,861,725
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G |
Pdzk1 |
PDZ domain containing 1 |
increases expression |
ISO |
Flurbiprofen results in increased expression of PDZK1 mRNA |
CTD |
PMID:16949054 |
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NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514
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G |
Penk |
proenkephalin |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of PENK mRNA |
CTD |
PMID:16949054 |
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NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
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G |
Pik3c3 |
phosphatidylinositol 3-kinase, catalytic subunit type 3 |
increases expression |
ISO |
Flurbiprofen results in increased expression of PIK3C3 mRNA |
CTD |
PMID:16949054 |
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NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
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G |
Pla2g4a |
phospholipase A2 group IVA |
multiple interactions |
ISO |
Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA] |
CTD |
PMID:15878913 |
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NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
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G |
Psca |
prostate stem cell antigen |
multiple interactions increases expression |
ISO |
[Flurbiprofen results in increased phosphorylation of and results in increased activity of PSCA protein] which results in increased expression of AKT1 protein; Akt-I-1,2 compound inhibits the reaction [Flurbiprofen results in increased expression of PSCA protein]; AKT1 protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]; HRAS protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA] |
CTD |
PMID:16949054 |
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NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
ISO EXP |
Flurbiprofen results in decreased activity of PTGS1 protein |
CTD |
PMID:9233713 PMID:9258749 PMID:18848576 |
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NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions decreases activity decreases degradation increases expression decreases expression |
EXP ISO |
Flurbiprofen inhibits the reaction [Zymosan results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [Zymosan results in increased expression of PTGS2 protein] Flurbiprofen results in decreased activity of PTGS2 protein Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone] Flurbiprofen results in decreased degradation of PTGS2 protein; Flurbiprofen results in decreased degradation of PTGS2 protein mutant form Flurbiprofen results in decreased activity of PTGS2 protein; Flurbiprofen results in decreased activity of PTGS2 protein mutant form Flurbiprofen results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen results in increased expression of PTGS2 mRNA; Flurbiprofen results in increased expression of PTGS2 protein Flurbiprofen inhibits the reaction [16,16-Dimethylprostaglandin E2 results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Flurbiprofen results in increased expression of and results in increased activity of PTGS2 protein Flurbiprofen results in decreased expression of PTGS2 mRNA |
CTD |
PMID:9099957 PMID:9258749 PMID:9321948 PMID:10594327 PMID:11095985 PMID:11099482 PMID:11112151 PMID:11405284 PMID:11687965 PMID:12517972 PMID:15878913 PMID:16949054 PMID:18848576 PMID:19758985 PMID:22245433 More...
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
Flurbiprofen inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] Flurbiprofen inhibits the reaction [Zymosan results in increased localization of and results in increased activity of RELA protein] |
CTD |
PMID:11099482 PMID:11291649 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rhog |
ras homolog family member G |
increases expression |
ISO |
Flurbiprofen results in increased expression of RHOG mRNA |
CTD |
PMID:16949054 |
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NCBI chr 1:156,618,713...156,630,710
Ensembl chr 1:156,615,349...156,631,257
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G |
Rhou |
ras homolog family member U |
increases expression |
ISO |
Flurbiprofen results in increased expression of RHOU mRNA |
CTD |
PMID:16949054 |
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NCBI chr19:51,641,408...51,651,249
Ensembl chr19:51,641,227...51,650,552
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
ISO |
Flurbiprofen inhibits the reaction [alitretinoin binds to RXRA protein]; RXRA protein promotes the reaction [Flurbiprofen results in decreased secretion of APP protein] |
CTD |
PMID:19659691 |
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NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Sell |
selectin L |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of SELL protein |
CTD |
PMID:12147693 |
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NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
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G |
Smoc2 |
SPARC related modular calcium binding 2 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of SMOC2 mRNA |
CTD |
PMID:16949054 |
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NCBI chr 1:55,262,472...55,391,804
Ensembl chr 1:55,262,530...55,391,693
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G |
Sox2 |
SRY-box transcription factor 2 |
increases expression |
ISO |
Flurbiprofen results in increased expression of SOX2 mRNA |
CTD |
PMID:16949054 |
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NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
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Srd5a1 |
steroid 5 alpha-reductase 1 |
decreases expression |
EXP |
Flurbiprofen results in decreased expression of SRD5A1 mRNA; Flurbiprofen results in decreased expression of SRD5A1 protein |
CTD |
PMID:31184881 |
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NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
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G |
Tgoln2 |
trans-golgi network protein 2 |
increases expression |
ISO |
Flurbiprofen results in increased expression of TGOLN2 mRNA |
CTD |
PMID:16949054 |
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NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164
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G |
Thrsp |
thyroid hormone responsive |
multiple interactions |
ISO |
Flurbiprofen inhibits the reaction [Arachidonic Acid results in decreased expression of THRSP mRNA] |
CTD |
PMID:10357836 |
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NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
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Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression multiple interactions |
ISO |
Flurbiprofen results in increased expression of TIMP1 protein [[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein; [Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA |
CTD |
PMID:19501039 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
Flurbiprofen analog promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein] |
CTD |
PMID:10903797 PMID:19659691 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53 |
tumor protein p53 |
multiple interactions increases response to substance decreases response to substance increases expression |
ISO |
Flurbiprofen results in increased abundance of and results in increased phosphorylation of TP53 protein TP53 protein results in increased susceptibility to Flurbiprofen TP53 protein mutant form results in decreased susceptibility to Flurbiprofen Flurbiprofen results in increased expression of TP53 protein |
CTD |
PMID:11687965 PMID:15710360 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Twist1 |
twist family bHLH transcription factor 1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of TWIST1 mRNA |
CTD |
PMID:16949054 |
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NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
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G |
Tyms |
thymidylate synthetase |
increases expression |
ISO |
Flurbiprofen results in increased expression of TYMS mRNA |
CTD |
PMID:16949054 |
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NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation |
ISO |
UGT1A1 protein results in increased glucuronidation of Flurbiprofen |
CTD |
PMID:15843492 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases glucuronidation |
ISO |
UGT1A3 protein results in increased glucuronidation of Flurbiprofen |
CTD |
PMID:15117964 PMID:15843492 |
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NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a5 |
UDP glucuronosyltransferase family 1 member A5 |
increases glucuronidation |
ISO |
UGT1A4 protein results in increased glucuronidation of Flurbiprofen |
CTD |
PMID:15843492 |
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NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
increases glucuronidation |
ISO |
UGT1A6 protein results in increased glucuronidation of Flurbiprofen |
CTD |
PMID:15843492 |
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NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of Flurbiprofen |
CTD |
PMID:15843492 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt2b17 |
UDP glucuronosyltransferase family 2 member B17 |
increases glucuronidation |
EXP |
UGT2B1 protein results in increased glucuronidation of Flurbiprofen |
CTD |
PMID:8302279 |
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NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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G |
Ugt2b7 |
UDP glucuronosyltransferase family 2 member B7 |
increases glucuronidation |
ISO |
UGT2B7 protein results in increased glucuronidation of Flurbiprofen |
CTD |
PMID:15843492 |
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NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of ABCC3 mRNA |
CTD |
PMID:23153324 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Ackr2 |
atypical chemokine receptor 2 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of ACKR2 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 8:121,559,563...121,573,633
Ensembl chr 8:121,561,211...121,573,582
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G |
Acta2 |
actin alpha 2, smooth muscle |
increases expression |
ISO |
Hexachlorobenzene results in increased expression of ACTA2 protein |
CTD |
PMID:28923513 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Agtr1a |
angiotensin II receptor, type 1a |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of AGTR1 protein |
CTD |
PMID:29277037 |
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NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions affects localization decreases expression affects expression increases expression affects binding increases localization |
ISO EXP |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Hexachlorobenzene results in decreased expression of AHR mRNA]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Hexachlorobenzene; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Hexachlorobenzene; Hexachlorobenzene binds to and results in increased activity of AHR protein; Hexachlorobenzene results in decreased expression of and affects the localization of AHR protein Hexachlorobenzene affects the localization of AHR protein Hexachlorobenzene results in decreased expression of AHR protein Hexachlorobenzene affects the expression of AHR mRNA Hexachlorobenzene affects the reaction [AHR protein affects the expression of CYP1A1 mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of EGFR mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of IGF1 mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFB1 mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFBR2 mRNA] Hexachlorobenzene results in increased expression of AHR protein Hexachlorobenzene binds to AHR protein [Diethylnitrosamine co-treated with Hexachlorobenzene] results in increased expression of AHR protein; Hexachlorobenzene inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] Hexachlorobenzene results in increased localization of AHR protein |
CTD |
PMID:2539049 PMID:9407059 PMID:15515957 PMID:16705413 PMID:18295415 PMID:21205633 PMID:26219504 PMID:26358519 PMID:27519288 PMID:28923513 PMID:29277037 More...
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Aif1 |
allograft inflammatory factor 1 |
affects expression |
EXP |
Hexachlorobenzene affects the expression of AIF1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions affects localization |
EXP |
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Hexachlorobenzene affects the localization of AIFM1 protein]; Reactive Oxygen Species promotes the reaction [Hexachlorobenzene affects the localization of AIFM1 protein] |
CTD |
PMID:23708402 |
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NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 mRNA]; AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 protein]; Hexachlorobenzene results in increased activity of and results in increased localization of AKT1 protein |
CTD |
PMID:16679308 PMID:17150971 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Akt2 |
AKT serine/threonine kinase 2 |
multiple interactions |
EXP |
[Hexachlorobenzene co-treated with Methylnitrosourea] results in increased phosphorylation of AKT2 protein |
CTD |
PMID:22245120 |
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NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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G |
Alad |
aminolevulinate dehydratase |
affects expression |
EXP |
Hexachlorobenzene affects the expression of ALAD mRNA |
CTD |
PMID:15159207 |
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NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Alas2 |
5'-aminolevulinate synthase 2 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of ALAS2 mRNA |
CTD |
PMID:15159207 |
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NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519
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G |
Alox15 |
arachidonate 15-lipoxygenase |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of ALOX15 mRNA |
CTD |
PMID:15159207 |
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NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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G |
Alox5ap |
arachidonate 5-lipoxygenase activating protein |
affects expression |
EXP |
Hexachlorobenzene affects the expression of ALOX5AP mRNA |
CTD |
PMID:15159207 |
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NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
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G |
Anxa1 |
annexin A1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of ANXA1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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G |
Bid |
BH3 interacting domain death agonist |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of BID protein |
CTD |
PMID:21787832 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
C1qb |
complement C1q B chain |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of C1QB mRNA |
CTD |
PMID:15159207 |
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NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
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G |
C1s |
complement C1s |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of C1S mRNA |
CTD |
PMID:15159207 |
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NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
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G |
C4bpa |
complement component 4 binding protein, alpha |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of C4BPA mRNA |
CTD |
PMID:15159207 |
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NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
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G |
Capg |
capping actin protein, gelsolin like |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CAPG mRNA |
CTD |
PMID:15159207 |
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NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856
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G |
Casp1 |
caspase 1 |
affects expression |
EXP |
Hexachlorobenzene affects the expression of CASP1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
increases expression increases activity multiple interactions |
EXP |
Hexachlorobenzene results in increased expression of CASP3 mRNA Hexachlorobenzene results in increased activity of CASP3 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorobenzene results in increased activity of CASP3 protein] |
CTD |
PMID:19815060 PMID:21787832 PMID:23708402 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases activity |
EXP |
Hexachlorobenzene results in increased activity of CASP8 protein |
CTD |
PMID:21787832 PMID:23708402 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions increases activity |
EXP |
Hexachlorobenzene results in increased cleavage of and results in increased activity of CASP9 protein Hexachlorobenzene results in increased activity of CASP9 protein |
CTD |
PMID:19182106 PMID:21787832 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CAT mRNA |
CTD |
PMID:15159207 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl20 |
C-C motif chemokine ligand 20 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CCL20 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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G |
Ccnd1 |
cyclin D1 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorobenzene results in increased expression of CCND1 protein] |
CTD |
PMID:26219504 PMID:28215542 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccne1 |
cyclin E1 |
multiple interactions |
ISO |
Hexachlorobenzene promotes the reaction [CDK2 protein binds to CCNE1 protein]; Hexachlorobenzene promotes the reaction [CDKN1B protein binds to CCNE1 protein] |
CTD |
PMID:28215542 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cd14 |
CD14 molecule |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CD14 mRNA |
CTD |
PMID:15159207 |
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NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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G |
Cd24 |
CD24 molecule |
affects expression |
EXP |
Hexachlorobenzene affects the expression of CD24 mRNA |
CTD |
PMID:15159207 |
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NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
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G |
Cd247 |
Cd247 molecule |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of CD3Z mRNA |
CTD |
PMID:15159207 |
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NCBI chr13:78,043,302...78,118,437
Ensembl chr13:78,043,307...78,122,263
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G |
Cd36 |
CD36 molecule |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CD36 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cd37 |
CD37 molecule |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of CD37 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 1:95,719,171...95,724,662
Ensembl chr 1:95,719,190...95,724,648
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G |
Cd3d |
CD3 delta subunit of T-cell receptor complex |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of CD3D mRNA |
CTD |
PMID:15159207 |
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NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809
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G |
Cd48 |
Cd48 molecule |
affects expression |
EXP |
Hexachlorobenzene affects the expression of CD48 mRNA |
CTD |
PMID:15159207 |
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NCBI chr13:84,184,884...84,209,144
Ensembl chr13:84,185,532...84,209,142
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G |
Cd5 |
Cd5 molecule |
affects expression |
EXP |
Hexachlorobenzene affects the expression of CD5 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 1:207,365,337...207,386,313
Ensembl chr 1:207,365,337...207,386,313
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G |
Cd52 |
CD52 molecule |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CD52 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 5:146,319,789...146,321,348
Ensembl chr 5:146,319,969...146,321,348
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G |
Cd59 |
CD59 molecule |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CD59 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
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G |
Cd63 |
Cd63 molecule |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CD63 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
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G |
Cd74 |
CD74 molecule |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of CD74 mRNA |
CTD |
PMID:15159207 |
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NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
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G |
Cd9 |
CD9 molecule |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CD9 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222
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G |
Cdh1 |
cadherin 1 |
multiple interactions |
EXP |
[Hexachlorobenzene results in decreased activity of GSK3B protein] which results in decreased expression of CDH1 protein |
CTD |
PMID:16679308 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
ISO |
Hexachlorobenzene promotes the reaction [CDK2 protein binds to CCNE1 protein] |
CTD |
PMID:28215542 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression multiple interactions |
EXP ISO |
Hexachlorobenzene results in increased expression of CDKN1B protein Hexachlorobenzene affects the reaction [CDKN1B protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [CDKN1B protein binds to CCNE1 protein] |
CTD |
PMID:25093615 PMID:28215542 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
increases methylation |
EXP |
Hexachlorobenzene results in increased methylation of CDKN2A promoter alternative form |
CTD |
PMID:26431795 |
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NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Cish |
cytokine inducible SH2-containing protein |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CISH mRNA |
CTD |
PMID:15159207 |
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NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
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G |
Clec4f |
C-type lectin domain family 4, member F |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CLEC4F mRNA |
CTD |
PMID:15159207 |
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NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775
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G |
Cma1 |
chymase 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CMA1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
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G |
Comt |
catechol-O-methyltransferase |
increases expression |
ISO |
Hexachlorobenzene results in increased expression of COMT protein |
CTD |
PMID:24365113 |
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NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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Cp |
ceruloplasmin |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CP mRNA |
CTD |
PMID:15159207 |
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NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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G |
Cpa3 |
carboxypeptidase A3 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CPA3 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 2:102,712,483...102,744,219
Ensembl chr 2:102,712,589...102,744,203
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G |
Csf2rb |
colony stimulating factor 2 receptor subunit beta |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CSF2RB mRNA |
CTD |
PMID:15159207 |
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NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CXCL1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
affects expression |
EXP |
Hexachlorobenzene affects the expression of CXCL10 mRNA |
CTD |
PMID:15159207 |
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NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CXCR4 mRNA |
CTD |
PMID:15159207 |
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NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
increases expression |
ISO |
Hexachlorobenzene results in increased expression of CYP11A1 protein |
CTD |
PMID:24365113 |
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NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression multiple interactions |
EXP ISO |
Hexachlorobenzene results in increased expression of CYP1A1 mRNA; Hexachlorobenzene results in increased expression of CYP1A1 protein Hexachlorobenzene affects the reaction [AHR protein affects the expression of CYP1A1 mRNA] Hexachlorobenzene results in increased expression of and results in increased activity of CYP1A1 protein |
CTD |
PMID:2539049 PMID:2845946 PMID:2856071 PMID:15159207 PMID:17202759 PMID:19879930 PMID:24365113 PMID:27519288 PMID:28923513 More...
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CYP1A2 mRNA; Hexachlorobenzene results in increased expression of CYP1A2 protein |
CTD |
PMID:2539049 PMID:2845946 PMID:2856071 PMID:9630449 PMID:10696772 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CYP1B1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2a3 |
cytochrome P450, family 2, subfamily a, polypeptide 3 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CYP2A3 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CYP2B1 protein |
CTD |
PMID:10696772 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases expression increases expression |
EXP |
Hexachlorobenzene results in decreased expression of CYP2E1 mRNA Hexachlorobenzene results in increased expression of CYP2E1 protein |
CTD |
PMID:10696772 PMID:15159207 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CYP3A2 mRNA |
CTD |
PMID:15159207 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
affects expression |
EXP |
Hexachlorobenzene affects the expression of CYP3A23-3A1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
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G |
Cyp4a8 |
cytochrome P450, family 4, subfamily a, polypeptide 8 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CYP4A8 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476
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G |
Cyp7b1 |
cytochrome P450 family 7 subfamily B member 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of CYP7B1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
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G |
Dio1 |
iodothyronine deiodinase 1 |
decreases activity increases activity |
EXP |
Hexachlorobenzene results in decreased activity of DIO1 protein Hexachlorobenzene results in increased activity of DIO1 protein |
CTD |
PMID:15664263 |
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NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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G |
Dio2 |
iodothyronine deiodinase 2 |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of DIO2 mRNA |
CTD |
PMID:29277037 |
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NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions increases expression increases phosphorylation |
ISO EXP |
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to Hexachlorobenzene; Hexachlorobenzene results in increased phosphorylation of and results in increased expression of EGFR protein Hexachlorobenzene results in increased expression of EGFR mRNA Hexachlorobenzene affects the reaction [AHR protein affects the expression of EGFR mRNA] AG 1879 inhibits the reaction [SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]]; Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of EGFR protein]; Hexachlorobenzene results in increased phosphorylation of and results in decreased expression of EGFR protein; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein] |
CTD |
PMID:18295415 PMID:21205633 PMID:22245120 PMID:23462309 PMID:28923513 |
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NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Emb |
embigin |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of EMB mRNA |
CTD |
PMID:15159207 |
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NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050
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G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of EPHX1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
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G |
Ephx2 |
epoxide hydrolase 2 |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of EPHX2 mRNA |
CTD |
PMID:15159207 |
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NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions decreases expression increases expression increases phosphorylation |
ISO EXP |
ESR1 protein affects the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein]; Fulvestrant promotes the reaction [Hexachlorobenzene results in decreased expression of ESR1 protein] Hexachlorobenzene results in increased expression of ESR1 protein Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in decreased phosphorylation of ESR1 protein]; Methylnitrosourea inhibits the reaction [Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]] Hexachlorobenzene results in increased phosphorylation of ESR1 protein |
CTD |
PMID:19879930 PMID:22245120 PMID:28923513 PMID:29277037 PMID:31923581 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Fas |
Fas cell surface death receptor |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of FAS protein |
CTD |
PMID:21787832 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of FASLG protein |
CTD |
PMID:21787832 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fcer1a |
Fc epsilon receptor Ia |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of FCER1A mRNA |
CTD |
PMID:15159207 |
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NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
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G |
Fcer2 |
Fc epsilon receptor II |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of FCER2A mRNA |
CTD |
PMID:15159207 |
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NCBI chr12:1,742,809...1,754,476
Ensembl chr12:1,742,815...1,754,476
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G |
Fcgr2a |
Fc gamma receptor 2A |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of FCGR3 mRNA |
CTD |
PMID:15159207 |
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NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
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G |
Fcgrt |
Fc gamma receptor and transporter |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of FCGRT mRNA |
CTD |
PMID:15159207 |
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NCBI chr 1:95,574,436...95,584,171
Ensembl chr 1:95,567,175...95,584,084
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G |
Fn1 |
fibronectin 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of FN1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of FOS protein |
CTD |
PMID:9630449 PMID:10696772 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions decreases expression |
EXP |
Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in decreased expression of FSHB protein] Hexachlorobenzene results in decreased expression of FSHB protein |
CTD |
PMID:22245120 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of GCLM mRNA |
CTD |
PMID:15159207 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gjb1 |
gap junction protein, beta 1 |
multiple interactions decreases expression |
EXP |
AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 mRNA]; AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 protein]; Estradiol affects the reaction [Hexachlorobenzene results in increased expression of GJB1 mRNA] Hexachlorobenzene results in decreased expression of GJB1 mRNA; Hexachlorobenzene results in decreased expression of GJB1 protein |
CTD |
PMID:12117784 PMID:17150971 |
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NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925
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G |
Gjb2 |
gap junction protein, beta 2 |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of GJB2 mRNA; Hexachlorobenzene results in decreased expression of GJB2 protein |
CTD |
PMID:12117784 |
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NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177
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G |
Glg1 |
golgi glycoprotein 1 |
affects expression |
EXP |
Hexachlorobenzene affects the expression of GLG1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr19:39,124,892...39,224,178
Ensembl chr19:39,124,641...39,224,178
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G |
Gpx3 |
glutathione peroxidase 3 |
affects expression |
EXP |
Hexachlorobenzene affects the expression of GPX3 mRNA |
CTD |
PMID:15159207 |
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NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases activity multiple interactions |
EXP |
Hexachlorobenzene results in decreased activity of GSK3B protein [Hexachlorobenzene results in decreased activity of GSK3B protein] which results in decreased expression of CDH1 protein |
CTD |
PMID:16679308 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
affects expression |
EXP |
Hexachlorobenzene affects the expression of GSTA2 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gsta3 |
glutathione S-transferase alpha 3 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of GSTA3 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
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G |
Gstm1 |
glutathione S-transferase mu 1 |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of GSTM1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstm2 |
glutathione S-transferase mu 2 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of GSTM2 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of GSTP1 protein |
CTD |
PMID:9630449 PMID:10696772 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
H2ax |
H2A.X variant histone |
increases expression |
ISO |
Hexachlorobenzene results in increased expression of H2AX protein |
CTD |
PMID:32156659 |
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NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
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G |
Hdc |
histidine decarboxylase |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of HDC mRNA |
CTD |
PMID:15159207 |
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NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
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G |
Hmbs |
hydroxymethylbilane synthase |
increases expression increases activity |
EXP |
Hexachlorobenzene results in increased expression of HMBS mRNA Hexachlorobenzene increases activity of Hmbs protein in liver |
CTD RGD |
PMID:15159207 PMID:1781034 |
RGD:25440495 |
NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
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G |
Hmox1 |
heme oxygenase 1 |
increases expression affects expression |
EXP |
Hexachlorobenzene results in increased expression of HMOX1 mRNA Hexachlorobenzene affects the expression of HMOX1 mRNA |
CTD |
PMID:15159207 PMID:22954530 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hp |
haptoglobin |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of HP mRNA |
CTD |
PMID:15159207 |
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NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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G |
Hsd17b2 |
hydroxysteroid (17-beta) dehydrogenase 2 |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of HSD17B2 mRNA |
CTD |
PMID:15159207 |
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NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
multiple interactions |
ISO |
[perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of HSD3B1 mRNA; [perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of HSD3B1 protein; STF-31 inhibits the reaction [[perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of HSD3B1 protein] |
CTD |
PMID:34311058 |
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NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Hsp90ab1 |
heat shock protein 90 alpha family class B member 1 |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of HSP90AB1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
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G |
Hspe1 |
heat shock protein family E (Hsp10) member 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of HSPE1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
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G |
Icam1 |
intercellular adhesion molecule 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of ICAM1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifng |
interferon gamma |
affects expression decreases expression increases expression |
EXP ISO |
Hexachlorobenzene affects the expression of IFNG mRNA Hexachlorobenzene results in decreased expression of IFNG protein Hexachlorobenzene results in increased expression of IFNG mRNA |
CTD |
PMID:9465272 PMID:11119253 PMID:11266329 PMID:15319175 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Igf1 |
insulin-like growth factor 1 |
affects expression increases secretion multiple interactions |
ISO |
Hexachlorobenzene affects the expression of IGF1 mRNA Hexachlorobenzene results in increased secretion of IGF1 protein 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of IGF1 mRNA]; 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein]; [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of and results in increased secretion of IGF1 protein; [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of IGF1 mRNA; ESR1 protein affects the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein] Hexachlorobenzene affects the reaction [AHR protein affects the expression of IGF1 mRNA] |
CTD |
PMID:28923513 PMID:31923581 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igf1r |
insulin-like growth factor 1 receptor |
increases expression multiple interactions |
EXP ISO |
Hexachlorobenzene results in increased expression of IGF1R protein [Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein; [perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased phosphorylation of IGF1R protein; Fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein]; Fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of IGF1R protein] Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased expression of IGF1R protein] |
CTD |
PMID:16237195 PMID:19879930 PMID:33571556 |
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NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
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G |
Igfbp2 |
insulin-like growth factor binding protein 2 |
multiple interactions |
ISO |
[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] affects the expression of IGFBP2 mRNA |
CTD |
PMID:31923581 |
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NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
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G |
Igfbp3 |
insulin-like growth factor binding protein 3 |
multiple interactions |
ISO |
[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] affects the expression of IGFBP3 mRNA |
CTD |
PMID:31923581 |
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NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
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G |
IgG-2a |
gamma-2a immunoglobulin heavy chain |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of IGG-2A mRNA |
CTD |
PMID:15159207 |
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G |
Igsf6 |
immunoglobulin superfamily, member 6 |
affects expression |
EXP |
Hexachlorobenzene affects the expression of IGSF6 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 1:175,610,167...175,620,662
Ensembl chr 1:175,610,167...175,620,722
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G |
Il10 |
interleukin 10 |
affects expression decreases expression |
EXP ISO |
Hexachlorobenzene affects the expression of IL10 mRNA; Hexachlorobenzene affects the expression of IL10 protein Hexachlorobenzene results in decreased expression of IL10 protein |
CTD |
PMID:11119253 PMID:15319175 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il15 |
interleukin 15 |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of IL15 mRNA |
CTD |
PMID:15159207 |
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NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
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G |
Il18 |
interleukin 18 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of IL18 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1b |
interleukin 1 beta |
affects expression |
EXP |
Hexachlorobenzene affects the expression of IL1B mRNA |
CTD |
PMID:15159207 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2 |
interleukin 2 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of IL2 mRNA |
CTD |
PMID:9465272 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il2ra |
interleukin 2 receptor subunit alpha |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of IL2RA mRNA |
CTD |
PMID:9465272 |
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NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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G |
Il2rb |
interleukin 2 receptor subunit beta |
affects expression |
EXP |
Hexachlorobenzene affects the expression of IL2RB mRNA |
CTD |
PMID:15159207 |
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NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054
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G |
Il4 |
interleukin 4 |
affects expression |
EXP |
Hexachlorobenzene affects the expression of IL4 protein |
CTD |
PMID:11119253 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il5 |
interleukin 5 |
decreases expression |
ISO |
Hexachlorobenzene results in decreased expression of IL5 protein |
CTD |
PMID:15319175 |
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NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of IL6 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Il6st |
interleukin 6 cytokine family signal transducer |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of IL6ST mRNA |
CTD |
PMID:15159207 |
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NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
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G |
Insr |
insulin receptor |
increases expression |
EXP ISO |
Hexachlorobenzene results in increased expression of INSR protein |
CTD |
PMID:16237195 PMID:19879930 |
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NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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G |
Irf1 |
interferon regulatory factor 1 |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of IRF1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
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G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions increases phosphorylation increases expression |
EXP ISO |
Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein] Hexachlorobenzene results in increased phosphorylation of IRS1 protein [Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein; fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]; fulvestrant inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of IRS1 protein] Hexachlorobenzene results in increased expression of IRS1 protein |
CTD |
PMID:16237195 PMID:19879930 |
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NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of JUN protein |
CTD |
PMID:9630449 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kdr |
kinase insert domain receptor |
increases expression |
ISO |
Hexachlorobenzene results in increased expression of KDR protein |
CTD |
PMID:26358519 |
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NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Lcn2 |
lipocalin 2 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of LCN2 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G |
Lhb |
luteinizing hormone subunit beta |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of LHB protein |
CTD |
PMID:22245120 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Lman1 |
lectin, mannose-binding, 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of LMAN1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr18:59,508,996...59,530,873
Ensembl chr18:59,508,996...59,530,851
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G |
Map3k1 |
mitogen-activated protein kinase kinase kinase 1 |
affects expression |
EXP |
Hexachlorobenzene affects the expression of MAP3K1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation affects localization |
ISO EXP |
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK1 protein]; Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK1 protein]; Protein Kinase Inhibitors inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK1 protein] [Hexachlorobenzene results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein Hexachlorobenzene affects the localization of MAPK1 protein |
CTD |
PMID:21205633 PMID:21787832 PMID:22245120 PMID:23708402 PMID:26219504 PMID:26358519 PMID:28923513 More...
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk14 |
mitogen activated protein kinase 14 |
affects expression |
EXP |
Hexachlorobenzene affects the expression of MAPK14 mRNA |
CTD |
PMID:15159207 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation affects localization |
ISO EXP |
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]; Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]; Protein Kinase Inhibitors inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein] [Hexachlorobenzene results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein Hexachlorobenzene affects the localization of MAPK3 protein |
CTD |
PMID:21205633 PMID:22245120 PMID:23708402 PMID:26219504 PMID:26358519 PMID:28923513 More...
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation |
EXP |
Hexachlorobenzene results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:23708402 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mcpt10 |
mast cell protease 10 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of MCPT10 mRNA |
CTD |
PMID:15159207 |
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NCBI chr15:29,915,483...29,918,540
Ensembl chr15:29,799,357...29,860,148
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G |
Med16 |
mediator complex subunit 16 |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of MED16 mRNA |
CTD |
PMID:23153324 |
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NCBI chr 7:9,798,641...9,811,172
Ensembl chr 7:9,798,668...9,811,172
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G |
Mmp2 |
matrix metallopeptidase 2 |
increases expression multiple interactions |
ISO |
Hexachlorobenzene results in increased expression of MMP2 mRNA; Hexachlorobenzene results in increased expression of MMP2 protein [perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of and results in increased activity of MMP2 protein; [perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of MMP2 mRNA; AG 1879 inhibits the reaction [Hexachlorobenzene results in increased expression of MMP2 protein]; picropodophyllin inhibits the reaction [[perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased activity of MMP2 protein]; RTKI cpd inhibits the reaction [Hexachlorobenzene results in increased expression of MMP2 protein] |
CTD |
PMID:23462309 PMID:33571556 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
increases expression multiple interactions |
EXP ISO |
Hexachlorobenzene results in increased expression of MMP9 mRNA alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein]; Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein; RTKI cpd inhibits the reaction [Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein] |
CTD |
PMID:15159207 PMID:23462309 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpst |
mercaptopyruvate sulfurtransferase |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of MPST mRNA |
CTD |
PMID:15159207 |
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NCBI chr 7:109,955,581...109,963,155
Ensembl chr 7:109,955,675...109,963,141
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G |
Mt1 |
metallothionein 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of MT1A mRNA |
CTD |
PMID:15159207 |
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NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of MTOR mRNA |
CTD |
PMID:15159207 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
[Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of NFE2L2 protein |
CTD |
PMID:28634113 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Nos1 |
nitric oxide synthase 1 |
affects expression |
ISO |
Hexachlorobenzene affects the expression of NOS1 protein |
CTD |
PMID:32526215 |
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NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nos2 |
nitric oxide synthase 2 |
affects expression |
ISO |
Hexachlorobenzene affects the expression of NOS2 protein |
CTD |
PMID:32526215 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
decreases expression affects expression |
EXP ISO |
Hexachlorobenzene results in decreased expression of NOS3 protein Hexachlorobenzene affects the expression of NOS3 protein |
CTD |
PMID:29277037 PMID:32526215 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of NQO1 mRNA |
CTD |
PMID:23153324 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr1d1 |
nuclear receptor subfamily 1, group D, member 1 |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of NR1D1 mRNA |
CTD |
PMID:23153324 |
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NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
ISO |
Hexachlorobenzene results in increased activity of NR1I3 protein |
CTD |
PMID:28927721 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Orm1 |
orosomucoid 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of ORM1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions decreases expression increases expression |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorobenzene results in increased expression of PCNA protein] Hexachlorobenzene results in decreased expression of PCNA protein |
CTD |
PMID:26219504 PMID:29277037 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pglyrp1 |
peptidoglycan recognition protein 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of PGLYRP1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 1:78,531,815...78,537,001
Ensembl chr 1:78,531,815...78,537,001
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G |
Plpp2 |
phospholipid phosphatase 2 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of PLPP2 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 7:10,175,918...10,184,032
Ensembl chr 7:10,175,948...10,184,071
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G |
Por |
cytochrome p450 oxidoreductase |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of POR mRNA |
CTD |
PMID:15159207 |
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NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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G |
Ppox |
protoporphyrinogen oxidase |
affects expression |
EXP |
Hexachlorobenzene affects the expression of PPOX mRNA |
CTD |
PMID:15159207 |
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NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805
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G |
Prdx2 |
peroxiredoxin 2 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of PRDX2 mRNA |
CTD |
PMID:15159207 |
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NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
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G |
Prl |
prolactin |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of PRL protein |
CTD |
PMID:22245120 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions |
ISO |
Hexachlorobenzene results in increased expression of PTGS2 protein alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]; Fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]; omega-N-Methylarginine inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein] |
CTD |
PMID:26358519 PMID:32526215 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
RatNP-3b |
defensin RatNP-3 precursor |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of RATNP-3B mRNA |
CTD |
PMID:15159207 |
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NCBI chr16:70,544,364...70,546,533
Ensembl chr16:70,513,888...70,546,522
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
[Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of RELA protein; Cholecalciferol inhibits the reaction [[Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of RELA protein] |
CTD |
PMID:28634113 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rgcc |
regulator of cell cycle |
affects expression |
EXP |
Hexachlorobenzene affects the expression of RGCC mRNA |
CTD |
PMID:15159207 |
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NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141
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G |
RT1-Bb |
RT1 class II, locus Bb |
affects expression increases expression |
EXP |
Hexachlorobenzene affects the expression of RT1-BB mRNA Hexachlorobenzene results in increased expression of RT1-BB mRNA |
CTD |
PMID:15159207 PMID:17202759 |
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NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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G |
RT1-Da |
RT1 class II, locus Da |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of RT1-DA mRNA |
CTD |
PMID:15159207 |
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NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
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G |
RT1-Db1 |
RT1 class II, locus Db1 |
affects expression |
EXP |
Hexachlorobenzene affects the expression of RT1-DB1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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G |
RT1-DMa |
RT1 class II, locus DMa |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of HLA-DMA mRNA |
CTD |
PMID:15159207 |
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NCBI chr20:4,707,028...4,710,432
Ensembl chr20:4,707,028...4,710,432
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G |
RT1-DMb |
RT1 class II, locus DMb |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of HLA-DMB mRNA |
CTD |
PMID:15159207 |
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NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340
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G |
RT1-S3 |
RT1 class Ib, locus S3 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of RT1-S3 mRNA |
CTD |
PMID:15159207 |
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NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
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G |
Rxrb |
retinoid X receptor beta |
increases activity |
ISO |
Hexachlorobenzene results in increased activity of RXRB protein |
CTD |
PMID:18207673 |
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NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773
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G |
S100a8 |
S100 calcium binding protein A8 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of S100A8 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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G |
S100a9 |
S100 calcium binding protein A9 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of S100A9 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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G |
Scnn1a |
sodium channel epithelial 1 subunit alpha |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of SCNN1A mRNA |
CTD |
PMID:23153324 |
|
NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181
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G |
Serpina7 |
serpin family A member 7 |
decreases expression |
ISO |
Hexachlorobenzene results in decreased expression of SERPINA7 protein |
CTD |
PMID:19750101 |
|
NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040
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G |
Sh2b3 |
SH2B adaptor protein 3 |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of LNK mRNA |
CTD |
PMID:15159207 |
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NCBI chr12:34,749,849...34,753,616
Ensembl chr12:34,731,911...34,753,616
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G |
Slc2a4 |
solute carrier family 2 member 4 |
decreases expression multiple interactions |
EXP ISO |
Hexachlorobenzene results in decreased expression of SLC2A4 protein [perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in decreased expression of SLC2A4 mRNA; [perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in decreased expression of SLC2A4 protein; STF-31 inhibits the reaction [[perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in decreased expression of SLC2A4 mRNA]; STF-31 inhibits the reaction [[perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in decreased expression of SLC2A4 protein] |
CTD |
PMID:31923579 PMID:34311058 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Smad3 |
SMAD family member 3 |
multiple interactions increases phosphorylation |
ISO |
AG 1879 inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]; Hexachlorobenzene results in increased phosphorylation of and affects the localization of SMAD3 protein |
CTD |
PMID:27519288 PMID:28923513 |
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NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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G |
Socs2 |
suppressor of cytokine signaling 2 |
affects expression |
EXP |
Hexachlorobenzene affects the expression of SOCS2 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
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G |
Socs3 |
suppressor of cytokine signaling 3 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of SOCS3 mRNA |
CTD |
PMID:15159207 |
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NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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G |
Sod1 |
superoxide dismutase 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of SOD1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
affects expression |
EXP |
Hexachlorobenzene affects the expression of SOD2 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sod3 |
superoxide dismutase 3 |
affects expression |
EXP |
Hexachlorobenzene affects the expression of SOD3 mRNA |
CTD |
PMID:15159207 |
|
NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions affects localization increases phosphorylation |
ISO EXP |
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of STAT5B protein]; [AG 1879 results in decreased activity of SRC protein] which results in decreased susceptibility to Hexachlorobenzene; Hexachlorobenzene affects the phosphorylation of and affects the activity of SRC protein; Hexachlorobenzene affects the reaction [CDKN1B protein binds to SRC protein] Hexachlorobenzene affects the localization of SRC protein Hexachlorobenzene results in increased phosphorylation of SRC protein AG 1879 inhibits the reaction [SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]]; Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of SRC protein]; Hexachlorobenzene results in increased expression of and results in increased phosphorylation of and results in increased activity of SRC protein; Hexachlorobenzene results in increased phosphorylation of and results in increased expression of SRC protein; Methylnitrosourea inhibits the reaction [Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of SRC protein]; SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein] |
CTD |
PMID:18295415 PMID:19879930 PMID:21205633 PMID:22245120 PMID:23462309 PMID:28215542 More...
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NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G |
Stat1 |
signal transducer and activator of transcription 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of STAT1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Stat5b |
signal transducer and activator of transcription 5B |
multiple interactions |
ISO EXP |
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of STAT5B protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein Hexachlorobenzene affects the expression of and affects the phosphorylation of STAT5B protein |
CTD |
PMID:21205633 PMID:22245120 |
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NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of SULT1A1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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G |
Sult1e1 |
sulfotransferase family 1E member 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of SULT1E1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
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G |
Tf |
transferrin |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of TF mRNA |
CTD |
PMID:15159207 |
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NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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G |
Tfrc |
transferrin receptor |
affects expression |
EXP |
Hexachlorobenzene affects the expression of TFRC mRNA |
CTD |
PMID:15159207 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G |
Tgfa |
transforming growth factor alpha |
multiple interactions |
ISO |
[Hexachlorobenzene co-treated with Diethylnitrosamine co-treated with Cholecalciferol] results in increased expression of TGFA protein; [Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of TGFA protein |
CTD |
PMID:28634113 |
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NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
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G |
Tgfb1 |
transforming growth factor, beta 1 |
increases expression multiple interactions affects expression |
EXP ISO |
Hexachlorobenzene results in increased expression of TGFB1 mRNA; Hexachlorobenzene results in increased expression of TGFB1 protein Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFB1 mRNA] Hexachlorobenzene affects the expression of TGFB1 mRNA alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of TGFB1 mRNA]; Hexachlorobenzene results in increased expression of and results in increased cleavage of TGFB1 protein |
CTD |
PMID:19182106 PMID:21787832 PMID:25093615 PMID:27519288 PMID:28923513 PMID:29277037 More...
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tgfb3 |
transforming growth factor, beta 3 |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of TGFB3 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
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G |
Tgfbr1 |
transforming growth factor, beta receptor 1 |
increases expression |
ISO |
Hexachlorobenzene results in increased expression of TGFBR1 mRNA |
CTD |
PMID:28923513 |
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NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
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G |
Tgfbr2 |
transforming growth factor, beta receptor 2 |
multiple interactions affects expression |
ISO |
Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFBR2 mRNA] Hexachlorobenzene affects the expression of TGFBR2 mRNA |
CTD |
PMID:28923513 |
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NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of TIMP1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of TIMP2 mRNA |
CTD |
PMID:15159207 |
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NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of TNFRSF1A mRNA |
CTD |
PMID:15159207 |
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NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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G |
Tsc22d1 |
TSC22 domain family, member 1 |
decreases expression |
EXP |
Hexachlorobenzene results in decreased expression of TSC22D1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958
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G |
Tshb |
thyroid stimulating hormone subunit beta |
multiple interactions |
ISO |
Hexachlorobenzene affects the expression of and affects the secretion of TSHB protein |
CTD |
PMID:19750101 |
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NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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G |
Ttr |
transthyretin |
affects binding |
EXP |
Hexachlorobenzene binds to TTR protein |
CTD |
PMID:2043046 |
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NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
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G |
Txnrd1 |
thioredoxin reductase 1 |
increases expression decreases expression |
EXP |
Hexachlorobenzene results in increased expression of TXNRD1 mRNA Hexachlorobenzene results in decreased expression of TXNRD1 mRNA |
CTD |
PMID:23153324 |
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NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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G |
Ugt2b17 |
UDP glucuronosyltransferase family 2 member B17 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of UGT2B1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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G |
Ugt8 |
UDP glycosyltransferase 8 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of UGT8 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 2:214,264,483...214,332,769
Ensembl chr 2:214,264,483...214,332,660
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G |
Urod |
uroporphyrinogen decarboxylase |
affects expression multiple interactions |
EXP ISO |
Hexachlorobenzene affects the expression of UROD mRNA Hexachlorobenzene promotes the reaction [Aminolevulinic Acid results in decreased activity of UROD protein] |
CTD |
PMID:8937451 PMID:15159207 |
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NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
increases expression |
EXP |
Hexachlorobenzene results in increased expression of VCAM1 mRNA |
CTD |
PMID:15159207 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Vdr |
vitamin D receptor |
multiple interactions |
ISO |
[Hexachlorobenzene co-treated with Diethylnitrosamine] results in decreased expression of VDR protein; Cholecalciferol inhibits the reaction [[Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of VDR protein] |
CTD |
PMID:28634113 |
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NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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G |
Vegfa |
vascular endothelial growth factor A |
increases secretion increases expression multiple interactions |
ISO |
Hexachlorobenzene results in increased secretion of VEGFA protein Hexachlorobenzene results in increased expression of VEGFA protein alpha-naphthoflavone affects the reaction [Hexachlorobenzene results in increased expression of VEGFA protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased secretion of VEGFA protein]; Fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of VEGFA protein]; Hexachlorobenzene results in increased expression of and results in increased secretion of VEGFA protein; omega-N-Methylarginine inhibits the reaction [Hexachlorobenzene results in increased expression of VEGFA protein] |
CTD |
PMID:26358519 PMID:32526215 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Scn4a |
sodium voltage-gated channel alpha subunit 4 |
affects activity |
ISO |
3-cresol affects the activity of SCN4A protein polymorphism |
CTD |
PMID:11282107 |
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NCBI chr10:91,246,936...91,296,670
Ensembl chr10:91,246,936...91,296,545
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G |
Thrb |
thyroid hormone receptor beta |
affects binding |
ISO |
metolcarb binds to THRB protein |
CTD |
PMID:28973306 |
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NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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G |
Nat1 |
N-acetyltransferase 1 |
decreases activity |
ISO |
N-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT1 protein |
CTD |
PMID:15720122 |
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NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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G |
Nat2 |
N-acetyltransferase 2 |
decreases activity |
ISO |
N-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT2 protein |
CTD |
PMID:19842618 |
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NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
[N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of HRAS gene |
CTD |
PMID:11275476 |
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NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Nat2 |
N-acetyltransferase 2 |
increases metabolic processing |
ISO |
NAT2 protein results in increased metabolism of N-hydroxy-4-aminobiphenyl |
CTD |
PMID:16857729 |
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NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
multiple interactions increases sulfation |
ISO |
N-hydroxy-4-aminobiphenyl inhibits the reaction [SULT1A1 protein results in increased sulfation of Estradiol] SULT1A1 protein results in increased sulfation of N-hydroxy-4-aminobiphenyl |
CTD |
PMID:17433394 |
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NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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G |
Sult1c2a |
sulfotransferase family, cytosolic, 1C, member 2a |
increases sulfation |
ISO |
SULT1C2 protein results in increased sulfation of N-hydroxy-4-aminobiphenyl |
CTD |
PMID:17433394 |
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NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
[N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of TP53 gene |
CTD |
PMID:11275476 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Casp1 |
caspase 1 |
decreases expression |
ISO |
nitroflurbiprofen results in decreased expression of CASP1 mRNA |
CTD |
PMID:15081244 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Cth |
cystathionine gamma-lyase |
multiple interactions |
EXP |
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CTH mRNA] |
CTD |
PMID:16491094 |
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NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] |
CTD |
PMID:16491094 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] |
CTD |
PMID:16491094 |
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NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Nos2 |
nitric oxide synthase 2 |
decreases expression multiple interactions |
ISO EXP |
nitroflurbiprofen results in decreased expression of NOS2 mRNA nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:8528547 PMID:15081244 PMID:16491094 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases activity |
ISO EXP |
nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein] nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein] nitroflurbiprofen results in decreased activity of RELA protein |
CTD |
PMID:12716482 PMID:16491094 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein] nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
CTD |
PMID:12716482 PMID:16491094 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases expression |
EXP |
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of AKT1 mRNA] |
CTD |
PMID:21705299 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alb |
albumin |
affects binding |
ISO |
2-cresol binds to ALB protein |
CTD |
PMID:11334365 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
EXP |
2-cresol results in increased expression of BAX mRNA Sodium Selenite inhibits the reaction [2-cresol results in increased expression of BAX mRNA] |
CTD |
PMID:21705299 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bche |
butyrylcholinesterase |
multiple interactions |
ISO |
[2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide binds to and results in decreased activity of BCHE protein] which results in increased abundance of 2-cresol |
CTD |
PMID:22898212 |
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NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression multiple interactions |
EXP |
2-cresol results in increased expression of BCL2 mRNA Sodium Selenite inhibits the reaction [2-cresol results in increased expression of BCL2 mRNA] |
CTD |
PMID:21705299 |
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NCBI chr13:22,689,783...22,853,920
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G |
Gabra1 |
gamma-aminobutyric acid type A receptor subunit alpha 1 |
multiple interactions |
EXP |
2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] |
CTD |
PMID:11399263 |
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NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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G |
Gabrb2 |
gamma-aminobutyric acid type A receptor subunit beta 2 |
multiple interactions |
EXP |
2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] |
CTD |
PMID:11399263 |
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NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
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G |
Gabrg2 |
gamma-aminobutyric acid type A receptor subunit gamma 2 |
multiple interactions |
EXP |
2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] |
CTD |
PMID:11399263 |
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NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression multiple interactions |
EXP |
2-cresol results in increased expression of PPARG mRNA Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PPARG mRNA] |
CTD |
PMID:21705299 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Prkca |
protein kinase C, alpha |
increases expression multiple interactions |
EXP |
2-cresol results in increased expression of PRKCA mRNA Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PRKCA mRNA] |
CTD |
PMID:21705299 |
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NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions |
EXP |
2-cresol results in increased expression of PTGS2 mRNA Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PTGS2 mRNA] |
CTD |
PMID:21705299 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Alb |
albumin |
affects binding |
ISO |
4-cresol binds to ALB protein |
CTD |
PMID:11334365 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Becn1 |
beclin 1 |
increases expression |
ISO EXP |
4-cresol results in increased expression of BECN1 protein |
CTD |
PMID:25668154 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Casp3 |
caspase 3 |
increases activity |
ISO |
4-cresol results in increased activity of CASP3 protein |
CTD |
PMID:25668154 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions increases cleavage |
ISO |
SQSTM1 mutant form inhibits the reaction [4-cresol results in increased cleavage of CASP8 protein] |
CTD |
PMID:25668154 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Cdh2 |
cadherin 2 |
multiple interactions affects localization |
EXP |
4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]; Go 6976 inhibits the reaction [4-cresol affects the localization of CDH2 protein]; Go 6976 inhibits the reaction [4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]] |
CTD |
PMID:23466501 |
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NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Ctnnd1 |
catenin delta 1 |
multiple interactions |
EXP |
4-cresol affects the localization of and results in decreased phosphorylation of CTNND1 protein; 4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]; Go 6976 inhibits the reaction [4-cresol affects the localization of and results in decreased phosphorylation of CTNND1 protein]; Go 6976 inhibits the reaction [4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]]; PRKCA mutant form inhibits the reaction [4-cresol affects the localization of and results in decreased phosphorylation of CTNND1 protein] |
CTD |
PMID:23466501 |
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NCBI chr 3:69,683,328...69,734,550
Ensembl chr 3:69,683,313...69,734,516
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G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
multiple interactions |
ISO |
4-cresol inhibits the reaction [IL1B protein results in increased expression of CX3CL1 protein] |
CTD |
PMID:16954166 |
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NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases metabolic processing |
ISO |
CYP1A2 protein results in increased metabolism of 4-cresol |
CTD |
PMID:16174805 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
increases metabolic processing |
ISO |
CYP2D6 protein results in increased metabolism of 4-cresol |
CTD |
PMID:16174805 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases metabolic processing |
ISO |
CYP2E1 protein results in increased metabolism of 4-cresol |
CTD |
PMID:16174805 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
F11r |
F11 receptor |
decreases expression |
ISO |
4-cresol results in decreased expression of F11R protein |
CTD |
PMID:16954166 |
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NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
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G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions decreases phosphorylation |
EXP |
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [4-cresol results in decreased phosphorylation of GJA1 protein]; PRKCA mutant form inhibits the reaction [4-cresol results in decreased phosphorylation of GJA1 protein] |
CTD |
PMID:22813906 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
4-cresol results in increased expression of HMOX1 mRNA |
CTD |
PMID:29214717 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 mRNA]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; 4-cresol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; 4-cresol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
CTD |
PMID:12427124 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
4-cresol inhibits the reaction [IL1B protein results in increased expression of CX3CL1 protein]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 mRNA]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; 4-cresol inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] |
CTD |
PMID:12427124 PMID:16954166 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases phosphorylation |
ISO |
4-cresol results in increased phosphorylation of JUN protein |
CTD |
PMID:25668154 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Mir139 |
microRNA 139 |
increases expression |
ISO |
4-cresol results in increased expression of MIR139 mRNA |
CTD |
PMID:32105654 |
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NCBI chr 1:155,878,828...155,878,895
Ensembl chr 1:155,878,825...155,878,902
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G |
Mir144 |
microRNA 144 |
decreases expression |
ISO |
4-cresol results in decreased expression of MIR144 mRNA |
CTD |
PMID:32105654 |
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NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430
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G |
Mir186 |
microRNA 186 |
increases expression |
ISO |
4-cresol results in increased expression of MIR186 mRNA |
CTD |
PMID:32105654 |
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NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:246,582,806...246,582,891
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G |
Mir188 |
microRNA 188 |
increases expression |
ISO |
4-cresol results in increased expression of MIR188 mRNA |
CTD |
PMID:32105654 |
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NCBI chr X:15,247,715...15,247,794
Ensembl chr X:15,247,715...15,247,794
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G |
Mir190b |
microRNA 190b |
increases expression |
ISO |
4-cresol results in increased expression of MIR190B mRNA |
CTD |
PMID:32105654 |
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NCBI chr 2:175,514,800...175,514,877
Ensembl chr 2:175,514,800...175,514,877
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G |
Mir196b |
microRNA 196b |
decreases expression |
ISO |
4-cresol results in decreased expression of MIR196B mRNA |
CTD |
PMID:32105654 |
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NCBI chr 4:81,330,487...81,330,571
Ensembl chr 4:81,330,487...81,330,571
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G |
Mir196c |
microRNA 196c |
decreases expression |
ISO |
4-cresol results in decreased expression of MIR196A-1 mRNA |
CTD |
PMID:32105654 |
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NCBI chr10:81,231,006...81,231,085
Ensembl chr10:81,231,006...81,231,085
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G |
Mir200b |
microRNA 200b |
decreases expression |
ISO |
4-cresol results in decreased expression of MIR200B mRNA |
CTD |
PMID:32105654 |
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NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366
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G |
Mir204 |
microRNA 204 |
increases expression |
ISO |
4-cresol results in increased expression of MIR204 mRNA |
CTD |
PMID:32105654 |
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