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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(R)-fluoxetine
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Accession:CHEBI:86991 term browser browse the term
Definition:An N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine that has R configuration. [The antidepressant drug fluoxetine is a racemate comprising equimolar amounts of (R)- and (S)-fluoxetine].
Synonyms:exact_synonym: (3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
 related_synonym: (+)-fluoxetine;   (R)-N-methyl-3-(4-trifluoromethylphenoxy)-3-phenylpropylamine;   (R)-N-methyl-3-(4-trifluoromethylphenyloxy)-3-(phenyl)propylamine;   (R)-N-methyl-3-phenyl-3-[(alpha,alpha,alpha-trifluoro-p-tolyl)oxy]propylamine;   (R)-N-methyl-gamma-(4-trifluoromethylphenoxy)-3-phenylpropylamine;   (R)-Prozac;   Formula=C17H18F3NO;   InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3/t16-/m1/s1;   InChIKey=RTHCYVBBDHJXIQ-MRXNPFEDSA-N;   SMILES=CNCC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1
 xref: CAS:100568-03-4;   PMID:19144769;   PMID:19788198;   PMID:20663810;   PMID:22903652;   PMID:22923967;   PMID:23885544;   PMID:24464553;   PMID:24997906;   Reaxys:4356432
 cyclic_relationship: is_conjugate_base_of CHEBI:86993;   is_enantiomer_of CHEBI:86992


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fluoxetine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aak1 AP2 associated kinase 1 decreases expression EXP Fluoxetine results in decreased expression of AAK1 mRNA CTD PMID:17033635 NCBI chr 4:118,653,851...118,806,796
Ensembl chr 4:118,655,728...118,795,774
JBrowse link
G Aanat aralkylamine N-acetyltransferase increases expression EXP Fluoxetine results in increased expression of AANAT mRNA CTD PMID:9951564, PMID:22291481 NCBI chr10:105,568,091...105,572,407
Ensembl chr10:105,568,091...105,572,403
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression EXP Fluoxetine results in increased expression of ACACA mRNA CTD PMID:28677866 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Fluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:15312242 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 increases expression EXP Fluoxetine results in increased expression of ADAM10 mRNA CTD PMID:17033635 NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 multiple interactions
increases expression
ISO ADARB1 protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]]; ADARB1 protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]]; ADARB1 protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 mRNA]; ADARB1 protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 protein]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 mRNA]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 protein]
Fluoxetine results in increased expression of ADARB1 mRNA; Fluoxetine results in increased expression of ADARB1 protein
CTD PMID:21320410 NCBI chr20:11,972,352...12,101,022
Ensembl chr20:11,972,381...12,101,047
JBrowse link
G Adcy8 adenylate cyclase 8 decreases expression EXP Fluoxetine results in decreased expression of ADCY8 mRNA CTD PMID:17033635 NCBI chr 7:105,353,883...105,593,372
Ensembl chr 7:105,353,913...105,592,804
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions ISO [Fluoxetine co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA CTD PMID:29107002 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Amelx amelogenin, X-linked decreases expression ISO Fluoxetine results in decreased expression of AMELX mRNA CTD PMID:21083617 NCBI chr  X:26,439,197...26,450,495
Ensembl chr  X:26,439,197...26,450,495
JBrowse link
G Ampd2 adenosine monophosphate deaminase 2 increases expression EXP Fluoxetine results in increased expression of AMPD2 mRNA CTD PMID:20924750 NCBI chr 2:210,861,624...210,874,348
Ensembl chr 2:210,861,625...210,874,304
JBrowse link
G Ano3 anoctamin 3 decreases expression EXP Fluoxetine results in decreased expression of ANO3 mRNA CTD PMID:17033635 NCBI chr 3:101,843,516...102,203,368
Ensembl chr 3:101,840,630...102,151,489
JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A decreases expression EXP Fluoxetine results in decreased expression of ANP32A mRNA CTD PMID:17033635 NCBI chr 8:67,295,578...67,333,075
Ensembl chr 8:67,295,727...67,333,247
JBrowse link
G Anxa1 annexin A1 decreases expression EXP Fluoxetine results in decreased expression of ANXA1 mRNA CTD PMID:21852994 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa5 annexin A5 multiple interactions
affects expression
ISO
EXP
Fluoxetine promotes the reaction [Phosphatidylserines binds to ANXA5 protein]
Fluoxetine affects the expression of ANXA5 mRNA
CTD PMID:16076491, PMID:21852994 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Fluoxetine results in decreased expression of AP1S1 mRNA CTD PMID:15342952 NCBI chr12:22,665,128...22,676,079
Ensembl chr12:22,665,112...22,676,075
JBrowse link
G Ap2a2 adaptor related protein complex 2 subunit alpha 2 multiple interactions ISO Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2A2 protein] CTD PMID:31631060 NCBI chr 1:214,534,217...214,607,497
Ensembl chr 1:214,534,284...214,606,169
JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 multiple interactions ISO Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2B1 protein] CTD PMID:31631060 NCBI chr10:70,516,462...70,621,973
Ensembl chr10:70,520,206...70,621,977
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 multiple interactions ISO
EXP
Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2M1 protein] CTD PMID:31631060 NCBI chr11:84,041,184...84,047,542
Ensembl chr11:84,041,184...84,047,546
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO
EXP
Fluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 mRNA]
Fluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 protein]
CTD PMID:25766885 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein decreases expression
increases expression
EXP Fluoxetine results in decreased expression of ARC mRNA
Fluoxetine results in increased expression of ARC mRNA
CTD PMID:15381288, PMID:17033635, PMID:18301726 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Arl4d ADP-ribosylation factor like GTPase 4D increases expression EXP Fluoxetine results in increased expression of ARL4D mRNA CTD PMID:18301726 NCBI chr10:89,577,556...89,580,368
Ensembl chr10:89,578,212...89,580,368
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like increases expression ISO Fluoxetine results in increased expression of ARNTL mRNA CTD PMID:15994025 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO Fluoxetine inhibits the reaction [Corticosterone results in decreased expression of ARRB1 mRNA] CTD PMID:19477151 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions
increases response to substance
ISO ARRB2 protein promotes the reaction [Fluoxetine results in increased expression of CREB1 protein]; ARRB2 protein promotes the reaction [Fluoxetine results in increased expression of MAPK3 protein]; Fluoxetine inhibits the reaction [Corticosterone results in decreased expression of ARRB2 mRNA]
ARRB2 protein results in increased susceptibility to Fluoxetine
CTD PMID:19477151 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Fluoxetine results in increased expression of ASAH1 mRNA CTD PMID:15342952, PMID:17567588 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Fluoxetine results in increased expression of ASNS mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression EXP Fluoxetine results in increased expression of ATP2A2 mRNA CTD PMID:21852994 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Avp arginine vasopressin decreases expression EXP Fluoxetine results in decreased expression of AVP mRNA CTD PMID:17033635 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Fluoxetine results in increased expression of BAD mRNA CTD PMID:21497159 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 decreases expression EXP Fluoxetine results in decreased expression of BAIAP2 mRNA CTD PMID:17033635 NCBI chr10:109,107,326...109,187,458
Ensembl chr10:109,107,389...109,187,115
JBrowse link
G Bcl11b BAF chromatin remodeling complex subunit BCL11B decreases expression EXP Fluoxetine results in decreased expression of BCL11B mRNA CTD PMID:17033635 NCBI chr 6:131,834,097...131,927,251
Ensembl chr 6:131,834,097...131,926,272
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases response to substance
decreases expression
ISO
EXP
BCL2 protein results in decreased susceptibility to Fluoxetine
Fluoxetine results in decreased expression of BCL2 protein
Fluoxetine results in decreased expression of BCL2 mRNA
CTD PMID:16076491, PMID:19298536, PMID:21497159 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
decreases expression
affects expression
EXP Fluoxetine results in increased expression of BCL2L1 mRNA; Fluoxetine results in increased expression of BCL2L1 protein
Fluoxetine results in decreased expression of BCL2L1 protein
Fluoxetine affects the expression of BCL2L1 mRNA
CTD PMID:19298536, PMID:21740920, PMID:21852994 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases response to substance
increases expression
multiple interactions
decreases expression
affects expression
affects response to substance
increases response to substance
ISO
EXP
BDNF protein mutant form results in decreased susceptibility to Fluoxetine
Fluoxetine results in increased expression of BDNF mRNA; Fluoxetine results in increased expression of BDNF protein
Fluoxetine affects the reaction [sodium arsenate affects the expression of BDNF protein]
Fluoxetine results in decreased expression of BDNF mRNA
Fluoxetine affects the expression of BDNF mRNA
Fluoxetine results in increased expression of BDNF mRNA; Fluoxetine results in increased expression of BDNF mRNA alternative form; Fluoxetine results in increased expression of BDNF protein
BDNF gene polymorphism affects the susceptibility to Fluoxetine
BDNF protein results in increased susceptibility to Fluoxetine
[Fluoxetine co-treated with Amantadine] results in increased expression of BDNF mRNA; [Fluoxetine co-treated with Ketanserin] results in increased expression of BDNF mRNA
CTD PMID:8601816, PMID:12504921, PMID:15381288, PMID:15456934, PMID:15555640, PMID:16035958, PMID:16887358, PMID:18301726, PMID:18973993, PMID:19211973, PMID:19775499, PMID:20016225, PMID:21048974, PMID:21301813, PMID:21627639, PMID:21945287, PMID:22218094, PMID:24125781, PMID:24952232 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 increases expression ISO Fluoxetine results in increased expression of BECN1 protein CTD PMID:20503272 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bet1l Bet1 golgi vesicular membrane trafficking protein-like increases expression EXP Fluoxetine results in increased expression of BET1L mRNA CTD PMID:20924750 NCBI chr 1:213,602,836...213,606,507
Ensembl chr 1:213,602,850...213,605,643
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 multiple interactions EXP Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of BMPR2 mRNA] CTD PMID:21619414 NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494
JBrowse link
G Brs3 bombesin receptor subtype 3 decreases expression EXP Fluoxetine results in decreased expression of BRS3 mRNA CTD PMID:21820738 NCBI chr  X:159,484,953...159,510,944
Ensembl chr  X:159,505,344...159,511,021
JBrowse link
G C1ql3 complement C1q like 3 decreases expression EXP Fluoxetine results in decreased expression of C1QL3 mRNA CTD PMID:17033635 NCBI chr17:80,314,186...80,320,681
Ensembl chr17:80,314,186...80,320,681
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G affects expression EXP Fluoxetine affects the expression of CACNA1G mRNA CTD PMID:21852994 NCBI chr10:82,129,071...82,197,828
Ensembl chr10:82,129,506...82,197,848
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H decreases expression EXP Fluoxetine results in decreased expression of CACNA1H mRNA CTD PMID:17033635 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression
multiple interactions
EXP Fluoxetine results in decreased expression of CAMK4 mRNA
Fluoxetine results in increased phosphorylation of and results in increased activity of CAMK4 protein
CTD PMID:15138445, PMID:17033635 NCBI chr18:25,746,878...25,975,962
Ensembl chr18:25,749,098...25,965,957
JBrowse link
G Cartpt CART prepropeptide decreases expression EXP Fluoxetine results in decreased expression of CARTPT protein CTD PMID:21167239 NCBI chr 2:30,125,249...30,127,408
Ensembl chr 2:30,125,249...30,127,269
JBrowse link
G Casp1 caspase 1 increases expression EXP Fluoxetine results in increased expression of CASP1 mRNA CTD PMID:28677866 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
EXP
ISO
Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of CASP3 protein]; Fluoxetine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]
Fluoxetine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Fluoxetine results in increased activity of CASP3 protein]
Fluoxetine results in increased cleavage of CASP3 protein
CTD PMID:18371935, PMID:19135049, PMID:19298536, PMID:21619414, PMID:22700542, PMID:28482088 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Fluoxetine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Fluoxetine results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases activity ISO Fluoxetine results in increased activity of CASP8 protein CTD PMID:28482088 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO Fluoxetine results in increased activity of CASP9 protein CTD PMID:28482088 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP Fluoxetine results in decreased activity of CAT protein
resveratrol inhibits the reaction [Fluoxetine results in decreased activity of CAT protein]
CTD PMID:26348076 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cck cholecystokinin decreases expression ISO
EXP
Fluoxetine results in decreased expression of CCK mRNA CTD PMID:17033635, PMID:17105902 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases secretion ISO Fluoxetine results in decreased secretion of CCL2 protein CTD PMID:21083617 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Fluoxetine inhibits the reaction [TNF protein results in increased expression of CCL5 protein] CTD PMID:17477857 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn3 cellular communication network factor 3 decreases expression EXP Fluoxetine results in decreased expression of CCN3 mRNA CTD PMID:17033635 NCBI chr 7:94,375,134...94,382,154
Ensembl chr 7:94,375,020...94,383,024
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Fluoxetine results in decreased expression of CCNA2 mRNA; Fluoxetine results in decreased expression of CCNA2 protein CTD PMID:18371935 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Fluoxetine results in decreased expression of CCNB1 mRNA CTD PMID:21497159 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
increases expression
ISO
EXP
Fluoxetine results in decreased expression of CCND1 mRNA
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Fluoxetine results in increased expression of CCND1 mRNA]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Fluoxetine results in increased expression of CCND1 protein]
Fluoxetine results in increased expression of CCND1 mRNA; Fluoxetine results in increased expression of CCND1 protein
CTD PMID:18573488, PMID:18836303 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Fluoxetine results in decreased expression of CCND3 mRNA CTD PMID:21497159 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 decreases expression
affects expression
multiple interactions
ISO Fluoxetine results in decreased expression of CCNE1 mRNA
Fluoxetine affects the expression of CCNE1 mRNA
[Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CCNE1 protein
CTD PMID:18371935, PMID:21497159 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Fluoxetine results in increased expression of CCNG2 mRNA CTD PMID:24356939 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cd8a CD8a molecule increases expression ISO Fluoxetine results in increased expression of CD8A protein CTD PMID:21497159 NCBI chr 4:99,217,640...99,243,352
Ensembl chr 4:99,239,115...99,243,351
JBrowse link
G Cdk5 cyclin-dependent kinase 5 decreases expression ISO Fluoxetine results in decreased expression of CDK5 mRNA CTD PMID:17105902 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
affects expression
ISO [Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CDKN1A protein
Fluoxetine results in increased expression of CDKN1A mRNA
Fluoxetine affects the expression of CDKN1A mRNA
CTD PMID:18371935, PMID:18836303 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
affects expression
multiple interactions
ISO Fluoxetine results in increased expression of CDKN1B mRNA
Fluoxetine affects the expression of CDKN1B mRNA
[Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CDKN1B protein
CTD PMID:18371935, PMID:21497159 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Fluoxetine results in increased expression of CDKN2A mRNA CTD PMID:21497159 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO Fluoxetine results in increased expression of CDKN2B mRNA CTD PMID:21497159 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Cdx1 caudal type homeo box 1 affects expression ISO Fluoxetine affects the expression of CDX1 mRNA CTD PMID:29893963 NCBI chr18:56,337,485...56,355,477
Ensembl chr18:56,338,336...56,355,490
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Fluoxetine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Fluoxetine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate] CTD PMID:20097249 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit decreases expression EXP Fluoxetine results in decreased expression of CHRNA5 mRNA CTD PMID:21820738 NCBI chr 8:59,561,817...59,590,172
Ensembl chr 8:59,561,721...59,590,172
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit decreases expression EXP Fluoxetine results in decreased expression of CHRNB4 mRNA CTD PMID:21820738 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B multiple interactions
decreases expression
ISO [Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CCNE1 protein; [Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CDKN1A protein; [Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CDKN1B protein; Fluoxetine binds to and results in decreased activity of CKS1B protein
Fluoxetine results in decreased expression of CKS1B mRNA
CTD PMID:18371935 NCBI chr 2:188,740,564...188,745,144
Ensembl chr 2:188,740,573...188,745,144
JBrowse link
G Clock clock circadian regulator increases expression ISO Fluoxetine results in increased expression of CLOCK mRNA CTD PMID:15994025 NCBI chr14:34,418,226...34,502,218
Ensembl chr14:34,446,616...34,502,218
JBrowse link
G Cnksr2 connector enhancer of kinase suppressor of Ras 2 decreases expression EXP Fluoxetine results in decreased expression of CNKSR2 mRNA CTD PMID:17033635 NCBI chr  X:39,711,001...39,953,860
Ensembl chr  X:39,711,201...39,951,847
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
decreases expression
EXP Fluoxetine results in decreased expression of and results in decreased phosphorylation of CNR1 protein
Fluoxetine results in decreased expression of CNR1 mRNA
CTD PMID:15936043, PMID:18722357 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
decreases expression
increases phosphorylation
multiple interactions
EXP
ISO
Fluoxetine results in increased expression of CREB1 mRNA
Fluoxetine results in decreased expression of CREB mRNA
Fluoxetine results in increased phosphorylation of CREB1 protein
Fluoxetine results in increased expression of CREB1 protein
ARRB2 protein promotes the reaction [Fluoxetine results in increased expression of CREB1 protein]; Fluoxetine affects the reaction [sodium arsenate affects the expression of CREB1 protein]; Fluoxetine results in decreased phosphorylation of and results in decreased activity of CREB1 protein
[Fluoxetine co-treated with Methylphenidate] results in increased expression of CREB mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of CREB protein; [Fluoxetine co-treated with olanzapine] results in decreased phosphorylation of CREB1 protein; Fluoxetine results in increased phosphorylation of and results in increased activity of CREB1 protein; Fluoxetine results in increased phosphorylation of and results in increased localization of CREB1 protein; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Fluoxetine results in increased phosphorylation of and results in increased activity of CREB1 protein]; staurosporine aglycone inhibits the reaction [Fluoxetine results in increased phosphorylation of CREB1 protein]
CTD PMID:8601816, PMID:14556240, PMID:15138445, PMID:16887358, PMID:18573488, PMID:19477151, PMID:20122921, PMID:21048974, PMID:21753012, PMID:24952232 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crh corticotropin releasing hormone decreases expression
increases expression
ISO
EXP
Fluoxetine results in decreased expression of CRH mRNA
Fluoxetine results in increased expression of CRH mRNA
CTD PMID:1351783, PMID:9740405, PMID:20374287 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 increases expression EXP Fluoxetine results in increased expression of CRHR1 mRNA CTD PMID:9740405 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Cry1 cryptochrome circadian regulator 1 affects expression ISO Fluoxetine affects the expression of CRY1 mRNA CTD PMID:15994025 NCBI chr 7:24,534,593...24,634,098
Ensembl chr 7:24,534,615...24,634,097
JBrowse link
G Cry2 cryptochrome circadian regulator 2 decreases expression ISO Fluoxetine results in decreased expression of CRY2 mRNA CTD PMID:15994025 NCBI chr 3:81,314,151...81,344,143
Ensembl chr 3:81,314,149...81,344,110
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions EXP [9,10-Dimethyl-1,2-benzanthracene co-treated with Fluoxetine] affects the expression of CSF1R protein; [9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of CSF1R protein CTD PMID:31332895 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Fluoxetine co-treated with Ketanserin] results in increased expression of CTNNB1 mRNA; Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of CTNNB1 protein] CTD PMID:21619414, PMID:21627639 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsk cathepsin K multiple interactions ISO Fluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:15312242 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO Fluoxetine results in decreased secretion of CXCL10 protein CTD PMID:21083617 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
multiple interactions
EXP Fluoxetine results in decreased expression of CYP11A1 mRNA
resveratrol inhibits the reaction [Fluoxetine results in decreased expression of CYP11A1 mRNA]
CTD PMID:26348076 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Fluoxetine results in decreased activity of CYP19A1 protein CTD PMID:26162595 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases expression EXP Fluoxetine results in decreased expression of CYP26B1 mRNA CTD PMID:17033635 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP Fluoxetine inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin] CTD PMID:19858067 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity
increases metabolic processing
affects metabolic processing
EXP
ISO
Fluoxetine inhibits the reaction [CYP2C6V1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
Fluoxetine results in decreased activity of CYP2C19 protein
Fluoxetine inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]; Fluoxetine inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Fluoxetine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Fluoxetine]
CYP2C19 gene polymorphism affects the metabolism of Fluoxetine; CYP2C19 protein affects the metabolism of Fluoxetine
CTD PMID:11453896, PMID:11752104, PMID:16236141, PMID:19858067, PMID:21915887, PMID:22652334 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity
multiple interactions
ISO Fluoxetine results in decreased activity of CYP2C8 protein
torsemide inhibits the reaction [Fluoxetine results in decreased activity of CYP2C8 protein]
CTD PMID:15304522 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 multiple interactions EXP Fluoxetine inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin] CTD PMID:19858067 NCBI chr 7:123,651,827...123,655,896
Ensembl chr 7:123,651,827...123,655,896
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects abundance
decreases activity
increases metabolic processing
decreases methylation
multiple interactions
affects response to substance
decreases metabolic processing
affects metabolic processing
ISO CYP2D6 gene polymorphism affects the abundance of Fluoxetine; CYP2D6 protein affects the abundance of Fluoxetine
Fluoxetine results in decreased activity of CYP2D6 protein
CYP2D6 protein results in increased metabolism of Fluoxetine
CYP2D22 protein results in increased metabolism of Fluoxetine
CYP2D6 protein results in decreased methylation of Fluoxetine
[Fluoxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate]
CYP2D6 protein affects the susceptibility to Fluoxetine
CYP2D6 gene mutant form results in decreased metabolism of Fluoxetine
CYP2D6 gene polymorphism affects the metabolism of Fluoxetine; CYP2D6 protein affects the metabolism of Fluoxetine
CTD PMID:10583026, PMID:10755579, PMID:12173784, PMID:14639062, PMID:14716707, PMID:14726986, PMID:15094477, PMID:15172931, PMID:15286053, PMID:16236141, PMID:16595712, PMID:17470523, PMID:26599973 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Fluoxetine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol] CTD PMID:12584149 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dab1 DAB adaptor protein 1 increases expression EXP Fluoxetine results in increased expression of DAB1 protein CTD PMID:19359144 NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115
JBrowse link
G Dap death-associated protein increases expression EXP Fluoxetine results in increased expression of DAP mRNA CTD PMID:21852994 NCBI chr 2:84,275,884...84,328,998
Ensembl chr 2:84,275,884...84,328,998
JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions
increases expression
increases response to substance
ISO
EXP
DBH protein promotes the reaction [Fluoxetine results in increased abundance of Serotonin]
Fluoxetine results in increased expression of DBH mRNA
DBH protein results in increased susceptibility to Fluoxetine
CTD PMID:15148402, PMID:20626387 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Dclk1 doublecortin-like kinase 1 increases expression EXP Fluoxetine results in increased expression of DCLK1 mRNA CTD PMID:18301726 NCBI chr 2:144,646,255...144,939,389
Ensembl chr 2:144,646,308...144,936,927
JBrowse link
G Ddn dendrin decreases expression EXP Fluoxetine results in decreased expression of DDN mRNA CTD PMID:17033635 NCBI chr 7:140,479,707...140,486,093
Ensembl chr 7:140,479,711...140,483,693
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Fluoxetine results in increased expression of DEPP1 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 increases expression EXP Fluoxetine results in increased expression of DGAT1 mRNA CTD PMID:28677866 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Dio3 iodothyronine deiodinase 3 increases activity
increases expression
multiple interactions
EXP Fluoxetine results in increased activity of DIO3 protein
Fluoxetine results in increased expression of DIO3 mRNA
SB 203580 inhibits the reaction [Fluoxetine results in increased expression of DIO3 mRNA]; U 0126 inhibits the reaction [Fluoxetine results in increased activity of DIO3 protein]; U 0126 inhibits the reaction [Fluoxetine results in increased expression of DIO3 mRNA]
CTD PMID:15456934 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 decreases expression EXP Fluoxetine results in decreased expression of DNAJA2 mRNA CTD PMID:21852994 NCBI chr19:22,569,999...22,588,143
Ensembl chr19:22,569,999...22,588,137
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression EXP Fluoxetine results in increased expression of DNAJB9 mRNA CTD PMID:21852994 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Drd2 dopamine receptor D2 decreases expression
affects expression
EXP Fluoxetine results in decreased expression of DRD2 mRNA
Fluoxetine affects the expression of DRD2
CTD PMID:11981225, PMID:26475043 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO DRD3 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine] CTD PMID:20021991 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Dusp5 dual specificity phosphatase 5 decreases expression EXP Fluoxetine results in decreased expression of CPG21 mRNA CTD PMID:17033635 NCBI chr 1:274,245,184...274,258,595
Ensembl chr 1:274,245,184...274,258,595
JBrowse link
G Dusp8 dual specificity phosphatase 8 increases expression EXP Fluoxetine results in increased expression of DUSP8 mRNA CTD PMID:9813294 NCBI chr 1:215,030,429...215,043,111
Ensembl chr 1:215,030,429...215,033,460
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases phosphorylation EXP Fluoxetine results in increased phosphorylation of EEF2 protein CTD PMID:16817885 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation
multiple interactions
ISO Fluoxetine results in increased phosphorylation of EGFR protein
[[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Fluoxetine results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Fluoxetine results in increased phosphorylation of EGFR protein]
CTD PMID:18758753, PMID:19662385 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
EXP [Fluoxetine co-treated with Methylphenidate] results in increased expression of EGR1 mRNA; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of EGR1 mRNA]
Fluoxetine results in increased expression of EGR1 mRNA
CTD PMID:19931852, PMID:21753012 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr3 early growth response 3 decreases expression EXP Fluoxetine results in decreased expression of EGR3 mRNA CTD PMID:17033635 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Egr4 early growth response 4 decreases expression EXP Fluoxetine results in decreased expression of EGR4 mRNA CTD PMID:17033635 NCBI chr 4:117,293,620...117,296,082
Ensembl chr 4:117,293,620...117,296,082
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation EXP Fluoxetine results in increased phosphorylation of EIF4E protein CTD PMID:16817885 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression EXP Fluoxetine results in increased expression of ELOVL6 mRNA CTD PMID:28677866 NCBI chr 2:234,187,490...234,296,124
Ensembl chr 2:234,189,105...234,296,145
Ensembl chr 2:234,189,105...234,296,145
JBrowse link
G Enam enamelin decreases expression ISO Fluoxetine results in decreased expression of ENAM mRNA CTD PMID:21083617 NCBI chr14:21,194,635...21,219,529
Ensembl chr14:21,194,664...21,219,454
JBrowse link
G Ephx4 epoxide hydrolase 4 decreases expression EXP Fluoxetine results in decreased expression of EPHX4 mRNA CTD PMID:17033635 NCBI chr14:3,360,680...3,389,996
Ensembl chr14:3,360,712...3,389,943
JBrowse link
G Evi2a ecotropic viral integration site 2A increases expression ISO Fluoxetine results in increased expression of EVI2A mRNA CTD PMID:24356939 NCBI chr10:66,870,048...66,873,948
Ensembl chr10:66,870,067...66,873,948
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Fluoxetine results in increased expression of FABP1 mRNA CTD PMID:15342952, PMID:17567588 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression EXP Fluoxetine results in increased expression of FGF1 mRNA CTD PMID:17033635 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP [Fluoxetine co-treated with olanzapine] results in increased expression of FGF2 mRNA CTD PMID:15158429 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fhl2 four and a half LIM domains 2 decreases expression EXP Fluoxetine results in decreased expression of FHL2 mRNA CTD PMID:21852994 NCBI chr 9:49,920,611...49,994,906
Ensembl chr 9:49,920,854...49,950,093
JBrowse link
G Fmod fibromodulin decreases expression EXP Fluoxetine results in decreased expression of FMOD mRNA CTD PMID:17033635 NCBI chr13:50,874,886...50,885,503
Ensembl chr13:50,873,605...50,885,563
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
affects expression
decreases expression
EXP
ISO
[Fluoxetine co-treated with Methylphenidate] results in increased expression of FOS mRNA; [Fluoxetine co-treated with Olanzapine] results in decreased expression of FOS protein; Fluoxetine inhibits the reaction [Fenfluramine results in increased expression of FOS protein]; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of FOS mRNA]; SB 206553 inhibits the reaction [Fluoxetine results in increased expression of FOS protein]
Fluoxetine results in increased expression of FOS mRNA; Fluoxetine results in increased expression of FOS protein
Fluoxetine affects the expression of FOS protein
Fluoxetine results in decreased expression of FOS mRNA
N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Fluoxetine results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [Fluoxetine results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [Fluoxetine results in increased expression of FOS protein]
CTD PMID:9452197, PMID:9740405, PMID:12527473, PMID:14556240, PMID:15609068, PMID:15953686, PMID:16521035, PMID:17033635, PMID:17987061, PMID:18758753, PMID:18836303, PMID:19429152, PMID:19931852, PMID:21753012 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Fluoxetine results in increased expression of FOSB mRNA; Fluoxetine results in increased expression of FOSB protein
N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of FOSB protein]; U 0126 inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]; U 0126 inhibits the reaction [Fluoxetine results in increased expression of FOSB protein]
CTD PMID:18758753 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta decreases expression EXP Fluoxetine results in decreased expression of GABRD mRNA CTD PMID:17033635 NCBI chr 5:172,797,478...172,809,374
Ensembl chr 5:172,797,450...172,809,353
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Fluoxetine results in increased expression of GAD1 mRNA CTD PMID:17033635 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression
decreases expression
EXP Fluoxetine results in increased expression of GAD2 protein
Fluoxetine results in decreased expression of GAD2 mRNA
CTD PMID:9526047, PMID:19359144 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Gak cyclin G associated kinase decreases expression EXP Fluoxetine results in decreased expression of GAK mRNA CTD PMID:21852994 NCBI chr14:2,100,104...2,174,332
Ensembl chr14:2,100,106...2,174,318
JBrowse link
G Gal galanin and GMAP prepropeptide increases expression ISO Fluoxetine results in increased expression of GAL mRNA CTD PMID:20816900 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Gap43 growth associated protein 43 decreases expression EXP Fluoxetine results in decreased expression of GAP43 mRNA CTD PMID:17950272 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression
multiple interactions
EXP Fluoxetine results in increased expression of GDNF mRNA
U 0126 inhibits the reaction [Fluoxetine results in increased expression of GDNF mRNA]
CTD PMID:15456934 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Fluoxetine results in increased expression of GDPD3 mRNA CTD PMID:17175557, PMID:17567588 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150
JBrowse link
G Gfap glial fibrillary acidic protein increases response to substance
increases expression
ISO GFAP protein results in increased susceptibility to Fluoxetine
Fluoxetine results in increased expression of GFAP mRNA; Fluoxetine results in increased expression of GFAP protein
CTD PMID:20857517, PMID:22113448 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP Fluoxetine results in increased expression of GJA1 protein CTD PMID:18585900 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Glo1 glyoxalase 1 increases response to substance ISO GLO1 protein results in increased susceptibility to Fluoxetine CTD PMID:22113448 NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610
JBrowse link
G Gna12 G protein subunit alpha 12 increases expression EXP Fluoxetine results in increased expression of GNA12 mRNA CTD PMID:1426031 NCBI chr12:15,890,202...15,971,212
Ensembl chr12:15,890,170...15,971,212
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression
multiple interactions
EXP
ISO
Fluoxetine results in decreased expression of GNAI2 mRNA
Fluoxetine inhibits the reaction [Corticosterone results in decreased expression of GNAI2 mRNA]
CTD PMID:19477151, PMID:21852994 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gnaq G protein subunit alpha q increases expression EXP Fluoxetine results in increased expression of GNAQ mRNA CTD PMID:1426031 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Gnas GNAS complex locus increases expression
decreases expression
EXP Fluoxetine results in increased expression of GNAS mRNA
Fluoxetine results in decreased expression of GNAS mRNA
CTD PMID:1426031, PMID:21852994 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gnb2 G protein subunit beta 2 decreases expression ISO Fluoxetine results in decreased expression of GNB2 mRNA CTD PMID:17105902 NCBI chr12:22,229,079...22,234,096
Ensembl chr12:22,229,079...22,234,096
JBrowse link
G Gpatch4 G patch domain containing 4 increases expression EXP Fluoxetine results in increased expression of GPATCH4 mRNA CTD PMID:17033635 NCBI chr 2:187,404,731...187,424,047
Ensembl chr 2:187,415,262...187,424,045
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 increases expression EXP Fluoxetine results in increased expression of GPD1 mRNA CTD PMID:17033635 NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression EXP Fluoxetine results in increased expression of GPX3 mRNA CTD PMID:20924750 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gramd2b GRAM domain containing 2B increases expression EXP Fluoxetine results in increased expression of GRAMD3 mRNA CTD PMID:17033635 NCBI chr18:51,492,196...51,591,028
Ensembl chr18:51,492,196...51,591,026
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 affects expression
multiple interactions
affects phosphorylation
EXP
ISO
Fluoxetine affects the expression of GRIA1 protein
PPP1R1B protein promotes the reaction [Fluoxetine affects the phosphorylation of GRIA1 protein]
CTD PMID:11880651, PMID:20417256 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases expression EXP Fluoxetine results in increased expression of GRIA2 protein CTD PMID:20417256 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 multiple interactions
increases expression
ISO ADARB1 protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 mRNA]; ADARB1 protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 protein]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 mRNA]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 protein]
Fluoxetine results in increased expression of GRIK2 mRNA; Fluoxetine results in increased expression of GRIK2 protein
CTD PMID:21320410 NCBI chr20:53,791,428...54,517,691
Ensembl chr20:53,789,760...54,517,709
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression EXP Fluoxetine results in increased expression of GRIN2A protein CTD PMID:20417256 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression EXP Fluoxetine results in increased expression of GSK3B protein CTD PMID:19359144 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hapln2 hyaluronan and proteoglycan link protein 2 decreases expression EXP Fluoxetine results in decreased expression of HAPLN2 mRNA CTD PMID:17033635 NCBI chr 2:187,395,104...187,402,076
Ensembl chr 2:187,396,349...187,401,786
JBrowse link
G Hdac2 histone deacetylase 2 increases expression
multiple interactions
EXP
ISO
Fluoxetine results in increased expression of HDAC2 mRNA; Fluoxetine results in increased expression of HDAC2 protein
Fluoxetine affects the reaction [sodium arsenate affects the expression of HDAC2 protein]
CTD PMID:16670375, PMID:24952232 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hdac5 histone deacetylase 5 increases response to substance ISO HDAC5 protein results in increased susceptibility to Fluoxetine CTD PMID:22113448 NCBI chr10:90,140,183...90,169,853
Ensembl chr10:90,140,183...90,151,042
JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression EXP Fluoxetine results in increased expression of HES1 mRNA; Fluoxetine results in increased expression of HES1 protein CTD PMID:19801843 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hes5 hes family bHLH transcription factor 5 increases expression EXP Fluoxetine results in increased expression of HES5 mRNA; Fluoxetine results in increased expression of HES5 protein CTD PMID:17033635, PMID:19801843 NCBI chr 5:172,364,421...172,365,188
Ensembl chr 5:172,364,421...172,365,188
JBrowse link
G Hes7 hes family bHLH transcription factor 7 affects expression ISO Fluoxetine affects the expression of HES7 mRNA CTD PMID:29893963 NCBI chr10:55,704,485...55,710,523
Ensembl chr10:55,707,164...55,709,687
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Fluoxetine results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Homer1 homer scaffold protein 1 decreases expression EXP Fluoxetine results in decreased expression of HOMER1 mRNA CTD PMID:17033635 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
JBrowse link
G Hoxc6 homeo box C6 affects expression ISO Fluoxetine affects the expression of HOXC6 mRNA CTD PMID:29893963 NCBI chr 7:144,612,230...144,626,036
Ensembl chr 7:144,623,555...144,625,516
JBrowse link
G Hpcal1 hippocalcin-like 1 increases expression EXP Fluoxetine results in increased expression of HPCAL1 mRNA CTD PMID:20924750 NCBI chr 6:43,001,920...43,109,083
Ensembl chr 6:43,001,948...43,109,071
JBrowse link
G Hpn hepsin increases expression ISO Fluoxetine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Hpx hemopexin decreases expression EXP Fluoxetine results in decreased expression of HPX mRNA CTD PMID:21852994 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO HRH1 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine] CTD PMID:20021991 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 increases expression EXP Fluoxetine results in increased expression of HSPB8 mRNA CTD PMID:20924750 NCBI chr12:45,905,371...45,920,014
Ensembl chr12:45,905,371...45,920,013
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
affects expression
decreases expression
increases response to substance
affects response to substance
increases expression
ISO
EXP
Fluoxetine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A mRNA]; Fluoxetine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A protein]
Fluoxetine affects the expression of HTR1A
Fluoxetine results in decreased expression of HTR1A mRNA
HTR1A gene polymorphism results in increased susceptibility to Fluoxetine; HTR1A protein results in increased susceptibility to Fluoxetine
HTR1A promoter polymorphism affects the susceptibility to Fluoxetine
Fluoxetine inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein]; Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [HTR1A protein results in increased susceptibility to Fluoxetine]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide promotes the reaction [Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]]
Fluoxetine results in increased expression of HTR1A mRNA
CTD PMID:10665824, PMID:11106871, PMID:15885359, PMID:16302021, PMID:16458487, PMID:18573488, PMID:21083617, PMID:26475043 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B decreases expression
increases expression
EXP Fluoxetine results in decreased expression of HTR1B mRNA
Fluoxetine results in increased expression of HTR1B mRNA
CTD PMID:8914125, PMID:10665824, PMID:10861803 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects response to substance
affects expression
decreases activity
increases expression
ISO
EXP
HTR2A protein affects the susceptibility to Fluoxetine
Fluoxetine affects the expression of HTR2A
Fluoxetine results in decreased activity of HTR2A protein
Fluoxetine results in increased expression of HTR2A mRNA
CTD PMID:10773209, PMID:19445393, PMID:20464512, PMID:21083617, PMID:26475043 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B increases expression
increases activity
multiple interactions
ISO Fluoxetine results in increased expression of HTR2B mRNA
Fluoxetine results in increased activity of HTR2B protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; [[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK1 protein] which results in increased expression of PLA2G4A protein; [[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK3 protein] which results in increased expression of PLA2G4A protein; [Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK1 protein; [Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK3 protein; [Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein; [Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein; [Fluoxetine results in increased expression of and results in increased activity of HTR2B protein] which results in increased metabolism of Glycogen; bisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; Calcium promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; Calcium promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; Fluoxetine binds to and results in increased activity of HTR2B protein; Fluoxetine promotes the reaction [mesulergine binds to HTR2B protein]; Fluoxetine results in increased expression of and results in increased activity of HTR2B protein; HTR2B protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]]; HTR2B protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 mRNA]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 protein]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 mRNA]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 protein]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]
CTD PMID:11930908, PMID:18758753, PMID:19662385, PMID:21083617, PMID:21320410 NCBI chr 9:93,112,781...93,130,135
Ensembl chr 9:93,112,805...93,125,014
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding
multiple interactions
increases expression
ISO
EXP
Fluoxetine binds to HTR2C protein
[[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; Fluoxetine binds to and results in increased activity of HTR2C protein
[Fluoxetine results in increased abundance of Serotonin] which results in decreased expression of HTR2C mRNA; Fluoxetine binds to and results in decreased activity of HTR2C protein; Fluoxetine inhibits the reaction [Serotonin binds to and results in increased activity of HTR2C protein]
Fluoxetine results in increased expression of HTR2C mRNA; Fluoxetine results in increased expression of HTR2C mRNA alternative form
CTD PMID:9050900, PMID:15659601, PMID:18083778, PMID:19662385, PMID:21083617, PMID:21554931 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Icam5 intercellular adhesion molecule 5 decreases expression EXP Fluoxetine results in decreased expression of ICAM5 mRNA CTD PMID:17033635 NCBI chr 8:22,050,222...22,057,209
Ensembl chr 8:22,050,222...22,057,209
JBrowse link
G Ifng interferon gamma increases expression ISO Fluoxetine results in increased expression of IFNG mRNA CTD PMID:21497159 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf2 insulin-like growth factor 2 decreases expression EXP Fluoxetine results in decreased expression of IGF2 mRNA CTD PMID:17033635 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 decreases expression EXP Fluoxetine results in decreased expression of IGFBP2 mRNA CTD PMID:17033635 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP Fluoxetine results in decreased expression of IL1B mRNA CTD PMID:21966942 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Fluoxetine results in increased expression of IL6 mRNA
CTD PMID:16413968, PMID:21575647 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Fluoxetine results in increased expression of INHBE mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Insig1 insulin induced gene 1 increases expression EXP Fluoxetine results in increased expression of INSIG1 mRNA CTD PMID:21852994 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein] CTD PMID:21575647 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itpka inositol-trisphosphate 3-kinase A decreases expression EXP Fluoxetine results in decreased expression of ITPKA mRNA CTD PMID:17033635 NCBI chr 3:111,545,007...111,553,605
Ensembl chr 3:111,545,007...111,553,604
JBrowse link
G Jag1 jagged canonical Notch ligand 1 increases expression EXP Fluoxetine results in increased expression of JAG1 mRNA; Fluoxetine results in increased expression of JAG1 protein CTD PMID:19801843 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Fluoxetine results in decreased expression of JUN mRNA CTD PMID:17105902, PMID:18836303 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcna3 potassium voltage-gated channel subfamily A member 3 decreases activity ISO Fluoxetine results in decreased activity of KCNA3 protein CTD PMID:17638537 NCBI chr 2:209,766,767...209,768,344
Ensembl chr 2:209,766,512...209,769,711
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 increases expression EXP Fluoxetine results in increased expression of KCNA5 mRNA; Fluoxetine results in increased expression of KCNA5 protein CTD PMID:19298536 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
G Kcna6 potassium voltage-gated channel subfamily A member 6 decreases expression EXP Fluoxetine results in decreased expression of KCNA6 mRNA CTD PMID:17033635 NCBI chr 4:159,253,934...159,287,193
Ensembl chr 4:159,253,934...159,287,193
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
affects response to substance
affects localization
ISO Fluoxetine binds to and results in decreased activity of KCNH2 protein; Fluoxetine inhibits the reaction [KCNH2 protein results in increased transport of Potassium]; Fluoxetine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Fluoxetine results in decreased activity of KCNH2 protein
KCNH2 protein affects the susceptibility to Fluoxetine
Fluoxetine affects the localization of KCNH2 protein
CTD PMID:11805215, PMID:15272206, PMID:16967046, PMID:21158687, PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Fluoxetine inhibits the reaction [[KCNJ3 protein co-treated with KCNJ5 protein] results in increased transport of Potassium]; Fluoxetine inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:12684268 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 multiple interactions ISO Fluoxetine inhibits the reaction [Methamphetamine results in decreased expression of KCNJ4 mRNA] CTD PMID:21886566 NCBI chr 7:120,717,378...120,744,602
Ensembl chr 7:120,717,375...120,744,602
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Fluoxetine inhibits the reaction [[KCNJ3 protein co-treated with KCNJ5 protein] results in increased transport of Potassium] CTD PMID:12684268 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Fluoxetine inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]; Fluoxetine inhibits the reaction [KCNJ6 protein results in increased transport of Potassium] CTD PMID:12684268 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Kcnk10 potassium two pore domain channel subfamily K member 10 decreases activity
affects response to substance
multiple interactions
increases expression
ISO Fluoxetine results in decreased activity of KCNK10 protein
KCNK10 mRNA affects the susceptibility to Fluoxetine
[KCNK2 mRNA co-treated with KCNK10 mRNA] affects the susceptibility to Fluoxetine
Fluoxetine results in increased expression of KCNK10 mRNA
CTD PMID:23022515 NCBI chr 6:122,417,079...122,549,532
Ensembl chr 6:122,419,046...122,545,899
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 multiple interactions
decreases activity
affects response to substance
decreases expression
decreases response to substance
EXP
ISO
Fluoxetine inhibits the reaction [Dexamethasone results in increased expression of KCNK2 mRNA]; Fluoxetine inhibits the reaction [Dexamethasone results in increased expression of KCNK2 protein]
[KCNK2 mRNA co-treated with KCNK10 mRNA] affects the susceptibility to Fluoxetine
Fluoxetine results in decreased activity of KCNK2 protein
KCNK2 mRNA affects the susceptibility to Fluoxetine
Fluoxetine results in decreased expression of KCNK2 mRNA
Fluoxetine results in decreased susceptibility to KCNK2 protein
Fluoxetine results in decreased expression of KCNK2 mRNA; Fluoxetine results in decreased expression of KCNK2 protein
CTD PMID:21069514, PMID:23022515 NCBI chr13:107,690,111...107,886,476
Ensembl chr13:107,690,087...107,886,476
JBrowse link
G Kcnv1 potassium voltage-gated channel modifier subfamily V member 1 decreases expression EXP Fluoxetine results in decreased expression of KCNV1 mRNA CTD PMID:17033635 NCBI chr 7:84,016,864...84,023,205
Ensembl chr 7:84,015,207...84,023,316
JBrowse link
G Klf10 Kruppel-like factor 10 increases expression EXP Fluoxetine results in increased expression of KLF10 mRNA CTD PMID:18301726 NCBI chr 7:77,156,010...77,162,096
Ensembl chr 7:77,156,006...77,162,148
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO Fluoxetine results in increased expression of KLHL24 mRNA CTD PMID:24356939 NCBI chr11:84,613,101...84,643,674
Ensembl chr11:84,615,760...84,633,504
JBrowse link
G L1cam L1 cell adhesion molecule multiple interactions
increases expression
EXP Ondansetron inhibits the reaction [Fluoxetine results in increased expression of L1CAM protein] CTD PMID:16900104 NCBI chr  X:156,901,244...156,928,064
Ensembl chr  X:156,909,913...156,928,057
JBrowse link
G Lmna lamin A/C decreases expression EXP Fluoxetine results in decreased expression of LMNA mRNA CTD PMID:21852994 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 increases expression EXP Fluoxetine results in increased expression of LRG1 mRNA CTD PMID:17033635 NCBI chr 9:10,952,424...10,954,664
Ensembl chr 9:10,952,374...10,954,681
JBrowse link
G Lss lanosterol synthase increases expression ISO Fluoxetine results in increased expression of LSS mRNA CTD PMID:15342952, PMID:17567588 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Map1b microtubule-associated protein 1B increases expression EXP Fluoxetine results in increased expression of MAP1B mRNA CTD PMID:17033635 NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases expression
decreases phosphorylation
decreases expression
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; [[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK1 protein] which results in increased expression of PLA2G4A protein; [[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK1 protein; [Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein; ADARB1 protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]]; bisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; Calcium promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]; HTR2B protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]
Fluoxetine results in increased phosphorylation of MAPK1 protein
Fluoxetine results in increased expression of MAPK1 protein
Fluoxetine results in decreased phosphorylation of MAPK1 protein
Fluoxetine results in decreased expression of MAPK1 mRNA
[Fluoxetine co-treated with Methylphenidate] results in increased expression of MAPK1 mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MAPK1 protein; Fluoxetine results in increased phosphorylation of and results in increased activity of MAPK1 protein; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Fluoxetine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Fluoxetine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:15138445, PMID:15456934, PMID:16413968, PMID:18573488, PMID:18758753, PMID:18836303, PMID:19662385, PMID:21320410, PMID:21753012, PMID:24125781 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO Fluoxetine results in increased phosphorylation of MAPK14 protein CTD PMID:16413968 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
increases expression
decreases phosphorylation
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; [[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK3 protein] which results in increased expression of PLA2G4A protein; [[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK3 protein; [Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein; ADARB1 protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Fluoxetine results in increased expression of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; Calcium promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]; HTR2B protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]
Fluoxetine results in increased phosphorylation of MAPK3 protein
Fluoxetine results in increased phosphorylation of and results in increased activity of MAPK3 protein; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Fluoxetine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Fluoxetine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Fluoxetine results in decreased phosphorylation of MAPK3 protein
CTD PMID:15138445, PMID:15456934, PMID:16413968, PMID:18573488, PMID:18758753, PMID:18836303, PMID:19477151, PMID:19662385, PMID:21320410, PMID:24125781 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression EXP Fluoxetine results in decreased expression of MAPK8 mRNA CTD PMID:20924750 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mbd1 methyl-CpG binding domain protein 1 increases expression EXP Fluoxetine results in increased expression of MBD1 mRNA; Fluoxetine results in increased expression of MBD1 protein CTD PMID:16670375 NCBI chr18:70,248,568...70,263,190
Ensembl chr18:70,248,713...70,263,164
JBrowse link
G Mc4r melanocortin 4 receptor decreases expression EXP Fluoxetine results in decreased expression of MC4R mRNA; Fluoxetine results in decreased expression of MC4R protein CTD PMID:18359080 NCBI chr18:62,612,838...62,614,725
Ensembl chr18:62,612,838...62,614,725
JBrowse link
G Mecp2 methyl CpG binding protein 2 increases expression EXP Fluoxetine results in increased expression of MECP2 mRNA; Fluoxetine results in increased expression of MECP2 mRNA alternative form; Fluoxetine results in increased expression of MECP2 protein CTD PMID:16670375 NCBI chr  X:156,650,389...156,713,813
Ensembl chr  X:156,655,960...156,705,233
JBrowse link
G Meox1 mesenchyme homeobox 1 affects expression ISO Fluoxetine affects the expression of MEOX1 mRNA CTD PMID:29893963 NCBI chr10:89,797,011...89,817,009
Ensembl chr10:89,797,038...89,816,491
JBrowse link
G Mif macrophage migration inhibitory factor affects response to substance EXP MIF affects the susceptibility to Fluoxetine CTD PMID:20177408 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mixl1 Mix paired-like homeobox 1 affects expression ISO Fluoxetine affects the expression of MIXL1 mRNA CTD PMID:29893963 NCBI chr13:97,278,258...97,282,299
Ensembl chr13:98,973,041...98,975,426
Ensembl chr13:98,973,041...98,975,426
JBrowse link
G Mmp20 matrix metallopeptidase 20 decreases expression ISO Fluoxetine results in decreased expression of MMP20 mRNA CTD PMID:21083617 NCBI chr 8:5,823,147...5,875,555
Ensembl chr 8:5,833,359...5,875,232
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases activity
ISO
EXP
Fluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]
[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of MMP9 protein
Fluoxetine results in decreased activity of MMP9 protein
CTD PMID:15312242, PMID:21966942, PMID:31332895 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [Fluoxetine co-treated with Methylphenidate] results in increased expression of MTOR mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MTOR protein CTD PMID:21753012 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases phosphorylation ISO Fluoxetine results in decreased phosphorylation of MYC protein CTD PMID:18836303 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nanog Nanog homeobox affects expression ISO Fluoxetine affects the expression of NANOG mRNA CTD PMID:29893963 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Ncam1 neural cell adhesion molecule 1 increases expression EXP Fluoxetine results in increased expression of NCAM1 mRNA CTD PMID:21852994 NCBI chr 8:53,836,797...54,134,881
Ensembl chr 8:53,839,098...53,901,358
JBrowse link
G Neurod2 neuronal differentiation 2 decreases expression EXP Fluoxetine results in decreased expression of NEUROD2 mRNA CTD PMID:17033635 NCBI chr10:86,280,865...86,282,681
Ensembl chr10:86,280,892...86,282,693
JBrowse link
G Nf1 neurofibromin 1 decreases expression ISO Fluoxetine results in decreased expression of NF1 mRNA CTD PMID:17105902 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression
ISO
EXP
Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
Fluoxetine results in increased expression of NFKBIA mRNA
CTD PMID:17033635, PMID:21575647 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngfr nerve growth factor receptor increases response to substance ISO NGFR protein results in increased susceptibility to Fluoxetine CTD PMID:19621217 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nodal nodal growth differentiation factor affects expression ISO Fluoxetine affects the expression of NODAL mRNA CTD PMID:29893963 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO Fluoxetine analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Fluoxetine analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Fluoxetine results in increased expression of NOS2 mRNA
CTD PMID:16413968, PMID:21467642, PMID:21575647 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Notch1 notch receptor 1 increases expression EXP Fluoxetine results in increased expression of NOTCH1 mRNA; Fluoxetine results in increased expression of NOTCH1 protein CTD PMID:19801843 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Npas2 neuronal PAS domain protein 2 affects expression ISO Fluoxetine affects the expression of NPAS2 mRNA CTD PMID:15994025 NCBI chr 9:45,901,262...46,081,880
Ensembl chr 9:45,901,741...46,081,880
JBrowse link
G Nptx2 neuronal pentraxin 2 increases expression EXP Fluoxetine results in increased expression of NPTX2 mRNA CTD PMID:18301726 NCBI chr12:12,014,638...12,025,547
Ensembl chr12:12,013,911...12,025,549
JBrowse link
G Npy neuropeptide Y increases expression
decreases secretion
affects expression
decreases expression
ISO
EXP
Fluoxetine results in increased expression of NPY mRNA
Fluoxetine results in decreased secretion of NPY mRNA; Fluoxetine results in decreased secretion of NPY protein
Fluoxetine affects the expression of NPY mRNA
Fluoxetine results in decreased expression of NPY mRNA
CTD PMID:8737424, PMID:9729278, PMID:16042082, PMID:20816900 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Npy1r neuropeptide Y receptor Y1 affects expression EXP Fluoxetine affects the expression of NPY1R mRNA CTD PMID:9729278 NCBI chr16:24,779,480...24,789,131
Ensembl chr16:24,779,477...24,788,740
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Fluoxetine results in increased expression of NR0B2 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects expression
decreases expression
increases expression
affects response to substance
ISO
EXP
Fluoxetine inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 mRNA]; Fluoxetine inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 protein]
Fluoxetine affects the expression of NR3C1 protein
Fluoxetine affects the reaction [sodium arsenate affects the expression of NR3C1 protein]; Fluoxetine promotes the reaction [Dexamethasone results in increased activity of NR3C1 protein]; Fluoxetine promotes the reaction [Hydrocortisone results in increased activity of NR3C1 protein]
Fluoxetine results in decreased expression of NR3C1 mRNA
Fluoxetine results in increased expression of NR3C1 mRNA; Fluoxetine results in increased expression of NR3C1 protein
NR3C1 protein affects the susceptibility to Fluoxetine
CTD PMID:10929085, PMID:11226678, PMID:11406320, PMID:12393271, PMID:12871829, PMID:15469896, PMID:15885359, PMID:20374287, PMID:21281618, PMID:24952232 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 decreases expression
increases expression
multiple interactions
EXP Fluoxetine results in decreased expression of NR3C2 mRNA
Fluoxetine results in increased expression of NR3C2 mRNA; Fluoxetine results in increased expression of NR3C2 protein
Fluoxetine affects the reaction [Dexamethasone binds to NR3C2 protein]
CTD PMID:1351783, PMID:10929085, PMID:11406320, PMID:12393271, PMID:21281618 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression ISO Fluoxetine results in decreased expression of NR4A2 mRNA CTD PMID:20857517 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression EXP Fluoxetine results in decreased expression of NR4A3 mRNA CTD PMID:17033635 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Nrgn neurogranin decreases expression EXP Fluoxetine results in decreased expression of NRGN mRNA CTD PMID:17033635 NCBI chr 8:40,015,049...40,023,193
Ensembl chr 8:40,015,049...40,023,193
JBrowse link
G Nrn1 neuritin 1 increases expression EXP Fluoxetine results in increased expression of NRN1 mRNA CTD PMID:18301726 NCBI chr17:27,925,054...28,002,946
Ensembl chr17:27,925,057...27,969,433
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression
multiple interactions
increases phosphorylation
EXP
ISO
Fluoxetine results in increased expression of NTRK2 mRNA; Fluoxetine results in increased expression of NTRK2 mRNA alternative form
Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2M1 protein]
Fluoxetine results in increased phosphorylation of NTRK2 protein
Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2A2 protein]; Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2B1 protein]; Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2M1 protein]; Fluoxetine results in increased phosphorylation of and results in increased activity of NTRK2 protein
CTD PMID:8601816, PMID:15456934, PMID:21666748, PMID:22396798, PMID:31631060 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Nucb1 nucleobindin 1 affects expression EXP Fluoxetine affects the expression of NUCB1 mRNA CTD PMID:21852994 NCBI chr 1:101,480,160...101,511,029
Ensembl chr 1:101,480,145...101,500,850
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Fluoxetine results in increased expression of NUPR1 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Olig2 oligodendrocyte transcription factor 2 increases expression ISO Fluoxetine results in increased expression of OLIG2 mRNA CTD PMID:20857517 NCBI chr11:31,389,514...31,392,890
Ensembl chr11:31,389,514...31,392,890
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
increases expression
ISO
EXP
Fluoxetine inhibits the reaction [Methamphetamine results in decreased expression of OPRM1 mRNA]; Fluoxetine inhibits the reaction [Methamphetamine results in decreased expression of OPRM1 protein]
Fluoxetine results in increased expression of OPRM1 protein
CTD PMID:16484055, PMID:21886566 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Otx2 orthodenticle homeobox 2 affects expression ISO Fluoxetine affects the expression of OTX2 mRNA CTD PMID:29893963 NCBI chr15:25,500,037...25,511,619
Ensembl chr15:25,502,019...25,505,691
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide decreases expression EXP Fluoxetine results in decreased expression of OXT mRNA CTD PMID:17033635 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G Oxtr oxytocin receptor multiple interactions
increases expression
EXP Fluoxetine affects the reaction [vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2 binds to OXTR protein]
Fluoxetine results in increased expression of OXTR protein
CTD PMID:15380831 NCBI chr 4:144,399,326...144,417,598
Ensembl chr 4:144,403,358...144,416,116
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta increases expression EXP Fluoxetine results in increased expression of P4HB mRNA CTD PMID:21852994 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 increases expression EXP Fluoxetine results in increased expression of PAQR8 mRNA CTD PMID:17033635 NCBI chr 9:27,005,270...27,054,591
Ensembl chr 9:27,034,022...27,051,002
JBrowse link
G Pax3 paired box 3 affects expression ISO Fluoxetine affects the expression of PAX3 mRNA CTD PMID:29893963 NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172
JBrowse link
G Pde4a phosphodiesterase 4A increases expression EXP Fluoxetine results in increased expression of PDE4A mRNA CTD PMID:12504921 NCBI chr 8:22,189,533...22,234,036
Ensembl chr 8:22,189,600...22,233,748
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression
affects expression
increases expression
EXP Fluoxetine results in decreased expression of PDE4B protein
Fluoxetine affects the expression of PDE4B mRNA
Fluoxetine results in increased expression of PDE4B mRNA
CTD PMID:12504921, PMID:20222156, PMID:22291481 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pde4d phosphodiesterase 4D affects expression EXP Fluoxetine affects the expression of PDE4D mRNA alternative form CTD PMID:12504921 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
G Pde8b phosphodiesterase 8B increases expression EXP Fluoxetine results in increased expression of PDE8B mRNA CTD PMID:22291481 NCBI chr 2:24,718,548...24,955,533
Ensembl chr 2:24,719,976...24,923,128
JBrowse link
G Pdyn prodynorphin affects expression
decreases expression
EXP Fluoxetine affects the expression of PDYN protein
Fluoxetine results in decreased expression of PDYN mRNA
CTD PMID:14997015, PMID:15936043 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Penk proenkephalin decreases expression EXP Fluoxetine results in decreased expression of PENK mRNA CTD PMID:9526047, PMID:15936043 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Per1 period circadian regulator 1 decreases expression ISO Fluoxetine results in decreased expression of PER1 mRNA CTD PMID:15994025 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
JBrowse link
G Per2 period circadian regulator 2 affects expression ISO Fluoxetine affects the expression of PER2 mRNA CTD PMID:15994025 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions
increases expression
ISO [[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK1 protein] which results in increased expression of PLA2G4A protein; [[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK3 protein] which results in increased expression of PLA2G4A protein; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A mRNA]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A protein]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A mRNA]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A protein]; U 0126 inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A mRNA]; U 0126 inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A protein]
Fluoxetine results in increased expression of PLA2G4A mRNA; Fluoxetine results in increased expression of PLA2G4A protein
CTD PMID:19662385 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Plcb1 phospholipase C beta 1 decreases expression EXP Fluoxetine results in decreased expression of PLCB1 mRNA; Fluoxetine results in decreased expression of PLCB1 protein CTD PMID:12527476 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plcl1 phospholipase C-like 1 increases expression ISO Fluoxetine results in increased expression of PLCL1 mRNA CTD PMID:24356939 NCBI chr 9:62,016,112...62,349,244
Ensembl chr 9:62,291,405...62,349,309
JBrowse link
G Plec plectin decreases expression EXP Fluoxetine results in decreased expression of PLEC mRNA CTD PMID:21852994 NCBI chr 7:117,230,319...117,291,859
Ensembl chr 7:117,230,319...117,289,961
JBrowse link
G Pmch pro-melanin-concentrating hormone decreases expression EXP Fluoxetine results in decreased expression of PMCH mRNA CTD PMID:17033635 NCBI chr 7:28,655,206...28,656,522
Ensembl chr 7:28,654,733...28,657,522
JBrowse link
G Pomc proopiomelanocortin increases expression
decreases expression
EXP Fluoxetine results in increased expression of POMC mRNA; Fluoxetine results in increased expression of POMC protein
Fluoxetine results in decreased expression of POMC mRNA
CTD PMID:15936043, PMID:16042082, PMID:18359080 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Pou5f1 POU class 5 homeobox 1 affects expression ISO Fluoxetine affects the expression of POU5F1 mRNA CTD PMID:29893963 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Fluoxetine inhibits the reaction [Serotonin results in increased localization of PPARG protein] CTD PMID:25766885 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B affects phosphorylation
increases response to substance
multiple interactions
increases expression
ISO Fluoxetine affects the phosphorylation of PPP1R1B protein
PPP1R1B protein results in increased susceptibility to Fluoxetine
PPP1R1B protein promotes the reaction [Fluoxetine affects the phosphorylation of GRIA1 protein]
Fluoxetine results in increased expression of PPP1R1B mRNA; Fluoxetine results in increased expression of PPP1R1B protein
CTD PMID:11880651 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Prkcg protein kinase C, gamma decreases expression EXP Fluoxetine results in decreased expression of PRKCG mRNA CTD PMID:17033635 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions EXP Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of PRKG1 protein] CTD PMID:21619414 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Prl prolactin multiple interactions
increases expression
ISO
EXP
[olanzapine co-treated with Fluoxetine] results in increased expression of PRL protein
Fluoxetine results in increased expression of PRL protein
CTD PMID:313977, PMID:9098464, PMID:16848655, PMID:19896213 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prss23 serine protease 23 decreases expression EXP Fluoxetine results in decreased expression of PRSS23 mRNA CTD PMID:17033635 NCBI chr 1:153,732,528...153,742,111
Ensembl chr 1:153,732,532...153,752,541
JBrowse link
G Psma3 proteasome 20S subunit alpha 3 affects expression EXP Fluoxetine affects the expression of PSMA3 mRNA CTD PMID:21852994 NCBI chr 6:93,423,029...93,444,223
Ensembl chr 6:93,423,002...93,444,240
JBrowse link
G Psmb4 proteasome 20S subunit beta 4 decreases expression EXP Fluoxetine results in decreased expression of PSMB4 mRNA CTD PMID:21852994 NCBI chr 2:196,043,546...196,046,320
Ensembl chr 2:196,043,618...196,046,311
JBrowse link
G Pter phosphotriesterase related decreases expression EXP Fluoxetine results in decreased expression of PTER mRNA CTD PMID:17033635 NCBI chr17:80,250,444...80,311,987
Ensembl chr17:80,250,521...80,311,981
JBrowse link
G Ptgds prostaglandin D2 synthase decreases expression ISO Fluoxetine results in decreased expression of PTGDS mRNA CTD PMID:17105902 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Fluoxetine results in decreased expression of PTGS2 mRNA; Fluoxetine results in decreased expression of PTGS2 protein CTD PMID:17033635, PMID:21554931, PMID:21966942 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta decreases expression EXP Fluoxetine results in decreased expression of PTK2B mRNA CTD PMID:17033635 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Qrfpr pyroglutamylated RFamide peptide receptor decreases expression EXP Fluoxetine results in decreased expression of QRFPR mRNA CTD PMID:21820738 NCBI chr 2:122,891,321...122,949,241
Ensembl chr 2:122,891,321...122,949,241
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
ISO Fluoxetine inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
Fluoxetine results in increased activity of RELA protein
CTD PMID:16413968, PMID:21575647 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Reln reelin increases expression EXP Fluoxetine results in increased expression of RELN mRNA CTD PMID:19359144 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Rgs3 regulator of G-protein signaling 3 increases expression EXP Fluoxetine results in increased expression of RGS3 mRNA CTD PMID:21852994 NCBI chr 5:78,429,017...78,567,281
Ensembl chr 5:78,428,669...78,567,288
JBrowse link
G Rprml reprimo-like decreases expression EXP Fluoxetine results in decreased expression of RPRML mRNA CTD PMID:17033635 NCBI chr10:91,710,495...91,711,499
Ensembl chr10:91,710,495...91,711,499
JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Fluoxetine affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:3,875,478...3,885,140
Ensembl chr20:3,875,706...3,881,461
JBrowse link
G S100b S100 calcium binding protein B increases response to substance
increases expression
ISO
EXP
S100B protein results in increased susceptibility to Fluoxetine
Fluoxetine results in increased expression of S100B protein
Fluoxetine results in increased expression of S100B mRNA; Fluoxetine results in increased expression of S100B protein
CTD PMID:12960766, PMID:20857517, PMID:22113448 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Samd4a sterile alpha motif domain containing 4A decreases expression EXP Fluoxetine results in decreased expression of SAMD4A mRNA CTD PMID:17033635 NCBI chr15:23,666,543...23,879,067
Ensembl chr15:23,665,202...23,878,539
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Fluoxetine results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO Fluoxetine results in increased expression of SERPINA3 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Serpini1 serpin family I member 1 increases expression EXP Fluoxetine results in increased expression of SERPINI1 mRNA CTD PMID:16637596 NCBI chr 2:174,013,058...174,111,693
Ensembl chr 2:174,013,288...174,111,752
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression EXP Fluoxetine results in increased expression of SGK1 mRNA CTD PMID:17033635 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Slc13a4 solute carrier family 13 member 4 decreases expression EXP Fluoxetine results in decreased expression of SLC13A4 mRNA CTD PMID:17033635 NCBI chr 4:62,796,732...62,841,053
Ensembl chr 4:62,797,677...62,840,357
JBrowse link
G Slc17a7 solute carrier family 17 member 7 increases expression
decreases expression
ISO
EXP
Fluoxetine results in increased expression of SLC17A7 mRNA; Fluoxetine results in increased expression of SLC17A7 protein
Fluoxetine results in decreased expression of SLC17A7 mRNA
CTD PMID:16111724, PMID:17033635 NCBI chr 1:101,161,265...101,172,292
Ensembl chr 1:101,161,252...101,173,174
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Fluoxetine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Fluoxetine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952, PMID:17567588 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc30a3 solute carrier family 30 member 3 decreases expression EXP Fluoxetine results in decreased expression of SLC30A3 mRNA CTD PMID:17033635 NCBI chr 6:26,629,752...26,650,106
Ensembl chr 6:26,642,783...26,650,105
JBrowse link
G Slc32a1 solute carrier family 32 member 1 decreases expression EXP Fluoxetine results in decreased expression of SLC32A1 protein CTD PMID:20707986 NCBI chr 3:155,102,980...155,107,815
Ensembl chr 3:155,103,150...155,107,817
JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions ISO [Fluoxetine co-treated with Caffeine] results in decreased expression of SLC6A15 mRNA CTD PMID:29107002 NCBI chr 7:45,328,207...45,381,920
Ensembl chr 7:45,328,105...45,382,229
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO Fluoxetine inhibits the reaction [SLC6A2 protein results in increased import of Biogenic Monoamines analog]; Fluoxetine inhibits the reaction [SLC6A2 protein results in increased import of Fluorescent Dyes] CTD PMID:28506818 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
affects expression
affects response to substance
ISO
EXP
SLC6A3 mutant form affects the reaction [Fluoxetine affects the abundance of Dopamine]
Fluoxetine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]; Fluoxetine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]; Fluoxetine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
Fluoxetine affects the expression of SLC6A3
SLC6A3 protein affects the susceptibility to Fluoxetine
CTD PMID:11797063, PMID:14691264, PMID:26475043, PMID:28506818, PMID:31009648 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects response to substance
decreases activity
decreases response to substance
affects expression
multiple interactions
decreases expression
increases response to substance
decreases localization
increases expression
ISO
EXP
SLC6A4 affects the susceptibility to Fluoxetine; SLC6A4 protein affects the susceptibility to Fluoxetine
Fluoxetine results in decreased activity of SLC6A4 protein
SLC6A4 gene polymorphism results in decreased susceptibility to Fluoxetine
Fluoxetine affects the expression of SLC6A4 protein
Fluoxetine binds to and results in decreased activity of SLC6A4 protein; Fluoxetine inhibits the reaction [SLC6A4 protein results in increased import of Biogenic Monoamines analog]; Fluoxetine inhibits the reaction [SLC6A4 protein results in increased import of Fluorescent Dyes]
Fluoxetine results in decreased expression of SLC6A4 mRNA; Fluoxetine results in decreased expression of SLC6A4 protein
SLC6A4 gene polymorphism results in increased susceptibility to Fluoxetine; SLC6A4 protein results in increased susceptibility to Fluoxetine
Fluoxetine results in decreased localization of SLC6A4 protein
[Estradiol co-treated with Fluoxetine] results in increased expression of SLC6A4 mRNA; [Fluoxetine results in decreased expression of SLC6A4 mRNA] which results in decreased abundance of Serotonin; Org 34850 promotes the reaction [Fluoxetine results in decreased expression of SLC6A4 protein]
Fluoxetine results in increased expression of SLC6A4 mRNA
CTD PMID:8914125, PMID:14573314, PMID:14604448, PMID:15936043, PMID:16272152, PMID:16951736, PMID:16982082, PMID:17289086, PMID:17950541, PMID:18496518, PMID:18561912, PMID:19616025, PMID:20010449, PMID:21083617, PMID:21382399, PMID:21554931, PMID:21740920, PMID:28506818 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Fluoxetine results in increased expression of SLC7A11 mRNA CTD PMID:24356939 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Smad1 SMAD family member 1 multiple interactions EXP Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of SMAD1 mRNA]; Fluoxetine inhibits the reaction [Monocrotaline results in decreased phosphorylation of SMAD1 protein] CTD PMID:21619414 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions
decreases activity
increases response to substance
ISO [Fluoxetine results in decreased expression of and results in decreased activity of SMPD1 protein] which results in decreased abundance of Ceramides; Fluoxetine results in decreased expression of and results in decreased activity of SMPD1 protein
Fluoxetine results in decreased activity of SMPD1 protein
SMPD1 protein results in increased susceptibility to Fluoxetine
CTD PMID:23770692 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
G Snd1 staphylococcal nuclease and tudor domain containing 1 increases expression EXP Fluoxetine results in increased expression of SND1 mRNA CTD PMID:21852994 NCBI chr 4:55,772,377...56,171,669
Ensembl chr 4:55,772,377...56,171,668
JBrowse link
G Sox2 SRY-box transcription factor 2 affects expression ISO Fluoxetine affects the expression of SOX2 mRNA CTD PMID:29893963 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Sp5 Sp5 transcription factor affects expression ISO Fluoxetine affects the expression of SP5 mRNA CTD PMID:29893963 NCBI chr 3:56,766,475...56,769,277
Ensembl chr 3:56,766,475...56,769,277
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 affects expression ISO Fluoxetine affects the expression of SPRY2 mRNA CTD PMID:29893963 NCBI chr15:90,172,769...90,177,823
Ensembl chr15:90,172,975...90,175,802
JBrowse link
G Sqle squalene epoxidase decreases expression EXP Fluoxetine results in decreased expression of SQLE mRNA CTD PMID:21852994 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO Fluoxetine results in decreased expression of SQSTM1 mRNA CTD PMID:17105902 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 affects expression EXP Fluoxetine affects the expression of SRSF5 mRNA CTD PMID:21852994 NCBI chr 6:104,611,026...104,640,033
Ensembl chr 6:104,611,026...104,615,302
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression
EXP resveratrol inhibits the reaction [Fluoxetine results in decreased expression of STAR mRNA] CTD PMID:26348076 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stc1 stanniocalcin 1 increases expression EXP Fluoxetine results in increased expression of STC1 mRNA CTD PMID:17033635 NCBI chr15:50,891,137...50,901,791
Ensembl chr15:50,891,127...50,903,162
JBrowse link
G Stxbp1 syntaxin binding protein 1 increases expression EXP Fluoxetine results in increased expression of STXBP1 mRNA CTD PMID:21852994 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417
JBrowse link
G Syn1 synapsin I increases expression EXP Fluoxetine results in increased expression of SYN1 mRNA CTD PMID:16887358 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link
G Syp synaptophysin increases expression
decreases expression
EXP
ISO
Fluoxetine results in increased expression of SYP mRNA
Fluoxetine results in decreased expression of SYP mRNA
CTD PMID:17950272, PMID:20857517 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Tagln transgelin decreases expression ISO Fluoxetine results in decreased expression of TAGLN mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tbx6 T-box transcription factor 6 affects expression ISO Fluoxetine affects the expression of TBX6 mRNA CTD PMID:29893963 NCBI chr 1:198,214,797...198,218,706
Ensembl chr 1:198,214,797...198,218,706
JBrowse link
G Tbxt T-box transcription factor T affects expression ISO Fluoxetine affects the expression of T mRNA CTD PMID:29893963 NCBI chr 1:52,887,067...52,900,691
Ensembl chr 1:52,887,067...52,894,832
JBrowse link
G Th tyrosine hydroxylase decreases expression
affects expression
increases expression
ISO
EXP
Fluoxetine results in decreased expression of TH mRNA
Fluoxetine affects the expression of TH
Fluoxetine results in increased expression of TH mRNA
CTD PMID:1351783, PMID:15936043, PMID:20374287, PMID:20626387, PMID:20857517, PMID:26475043 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of TIMP1 protein CTD PMID:31332895 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tmc4 transmembrane channel-like 4 decreases expression EXP Fluoxetine results in decreased expression of TMC4 mRNA CTD PMID:17033635 NCBI chr 1:64,114,687...64,126,576
Ensembl chr 1:64,046,377...64,126,611
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
decreases activity
ISO Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Fluoxetine results in increased expression of TNF mRNA
Fluoxetine results in decreased activity of TNF protein
Fluoxetine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Fluoxetine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]
CTD PMID:16413968, PMID:17477857, PMID:21497159, PMID:21575647 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Fluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Fluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Fluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA] CTD PMID:15312242 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Fluoxetine results in increased expression of TRP53 mRNA
Fluoxetine results in increased expression of TP53 mRNA
CTD PMID:18836303, PMID:21497159 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tph1 tryptophan hydroxylase 1 increases expression ISO
EXP
Fluoxetine results in increased expression of TPH1 mRNA CTD PMID:15631896, PMID:21083617 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link
G Tph2 tryptophan hydroxylase 2 increases expression
decreases expression
increases response to substance
affects expression
affects response to substance
multiple interactions
EXP
ISO
Fluoxetine results in increased expression of TPH2 mRNA
Fluoxetine results in decreased expression of TPH2 mRNA
TPH2 results in increased susceptibility to Fluoxetine
Fluoxetine affects the expression of TPH2 mRNA
TPH2 protein affects the susceptibility to Fluoxetine
[Estradiol co-treated with Fluoxetine] results in increased expression of TPH2 mRNA
CTD PMID:11901216, PMID:16982082, PMID:17321503, PMID:17950541, PMID:20374287, PMID:21382399, PMID:21740920 NCBI chr 7:58,042,279...58,149,220
Ensembl chr 7:58,042,281...58,149,061
JBrowse link
G Tpm1 tropomyosin 1 decreases expression EXP Fluoxetine results in decreased expression of TPM1 mRNA CTD PMID:21852994 NCBI chr 8:72,814,737...72,841,496
Ensembl chr 8:72,814,740...72,842,228
JBrowse link
G Tshb thyroid stimulating hormone subunit beta increases expression EXP Fluoxetine results in increased expression of TSHB mRNA CTD PMID:17033635 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Tssk2 testis-specific serine kinase 2 decreases expression EXP Fluoxetine results in decreased expression of TSSK2 mRNA CTD PMID:17033635 NCBI chr11:87,235,058...87,236,413
Ensembl chr11:87,221,613...87,236,445
JBrowse link
G Ttr transthyretin increases expression ISO Fluoxetine results in increased expression of TTR mRNA CTD PMID:17105902 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO Fluoxetine results in decreased expression of TUBB3 mRNA CTD PMID:20857517 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
ISO
EXP
Fluoxetine results in increased expression of VEGFA mRNA
[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of VEGFA protein
CTD PMID:21301813, PMID:31332895 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vgf VGF nerve growth factor inducible increases expression ISO Fluoxetine results in increased expression of VGF mRNA CTD PMID:21301813 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630
JBrowse link
G Vldlr very low density lipoprotein receptor increases expression EXP
ISO
Fluoxetine results in increased expression of VLDLR protein
Fluoxetine results in increased expression of VLDLR mRNA
CTD PMID:19359144, PMID:24356939 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein decreases expression EXP Fluoxetine results in decreased expression of WFS1 mRNA CTD PMID:17033635 NCBI chr14:78,640,707...78,665,224
Ensembl chr14:78,640,620...78,665,966
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Fluoxetine results in increased expression of WIPI1 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link
G Wnt3a Wnt family member 3A increases phosphorylation
affects expression
EXP
ISO
Fluoxetine results in increased phosphorylation of WNT3A protein
Fluoxetine affects the expression of WNT3A mRNA
CTD PMID:21048974, PMID:29893963 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression EXP Fluoxetine results in increased expression of XIAP mRNA CTD PMID:17033635 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Xpo1 exportin 1 decreases expression
increases expression
EXP Fluoxetine results in decreased expression of XPO1 mRNA
Fluoxetine results in increased expression of XPO1 mRNA
CTD PMID:21852994 NCBI chr14:108,007,421...108,049,088
Ensembl chr14:108,007,724...108,049,660
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon affects expression EXP Fluoxetine affects the expression of YWHAE mRNA CTD PMID:21852994 NCBI chr10:63,884,338...63,921,709
Ensembl chr10:63,884,338...63,921,709
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta affects expression EXP Fluoxetine affects the expression of YWHAH mRNA CTD PMID:21852994 NCBI chr14:83,053,041...83,062,424
Ensembl chr14:83,053,041...83,062,424
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta increases expression EXP Fluoxetine results in increased expression of YWHAZ mRNA; Fluoxetine results in increased expression of YWHAZ protein CTD PMID:15631896 NCBI chr 7:75,573,553...75,598,295
Ensembl chr 7:75,574,967...75,597,276
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          neurotransmitter agent 16425
            serotonergic drug 3957
              serotonin uptake inhibitor 3322
                (R)-fluoxetine 332
                  fluoxetine 332
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            organic hydride 18249
                              organic fundamental parent 18249
                                hydrocarbon 17969
                                  halohydrocarbon 13937
                                    haloalkane 11657
                                      fluoroalkane 7110
                                        fluoromethanes 6330
                                          tetrafluoromethane 6330
                                            trifluoromethyl group 6330
                                              (trifluoromethyl)benzenes 6330
                                                N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine 332
                                                  (R)-fluoxetine 332
                                                    fluoxetine 332
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.