CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: pyrvinium
Accession: CHEBI:8687
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Definition: A quinolinium ion that is 1-methylquinolinium substituted by dimethylamino group at position 6 and a (E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl at position 2. It is a anthelminthic drug active against pinworms. The salts of pyrvinium can also be used as anticancer agents.
Synonyms: exact_synonym: 6-(dimethylamino)-2-[(E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methylquinolinium
related_synonym: Formula=C26H28N3; InChI=1S/C26H28N3/c1-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5/h6-18H,1-5H3/q+1; InChIKey=QMHSXPLYMTVAMK-UHFFFAOYSA-N; SMILES=CN(C)c1ccc2[n+](C)c(\\C=C\\c3cc(C)n(c3C)-c3ccccc3)ccc2c1
xref: CAS:7187-62-4; Drug_Central:2335; KEGG:C07412
xref_mesh: MESH:C024631
xref: PMID:22332749; Patent:GB834990; Reaxys:4159167; Wikipedia:Pyrvinium
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
ISO
pyrvinium results in decreased phosphorylation of AKT1 protein
CTD
PMID:27542212
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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Axin2
axin 2
decreases expression
ISO
pyrvinium results in decreased expression of AXIN2 mRNA
CTD
PMID:21170416
NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
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Ccl2
C-C motif chemokine ligand 2
decreases expression
ISO
pyrvinium results in decreased expression of CCL2 protein
CTD
PMID:20116850
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Ccne2
cyclin E2
multiple interactions
ISO
pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]
CTD
PMID:27542212
NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
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Ccng2
cyclin G2
multiple interactions
ISO
pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]
CTD
PMID:27542212
NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
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Csgalnact1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
multiple interactions
ISO
pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]
CTD
PMID:27542212
NCBI chr16:22,704,318...23,075,071
Ensembl chr16:22,979,444...23,074,798
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Csnk1a1
casein kinase 1, alpha 1
decreases activity
ISO
pyrvinium results in decreased activity of CSNK1A1 protein
CTD
PMID:21170416
NCBI chr18:56,887,722...56,910,610
Ensembl chr18:56,887,354...56,918,345
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Dkk1
dickkopf WNT signaling pathway inhibitor 1
decreases expression
ISO
pyrvinium results in decreased expression of DKK1 mRNA
CTD
PMID:21170416
NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
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Dscc1
DNA replication and sister chromatid cohesion 1
multiple interactions
ISO
pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]
CTD
PMID:27542212
NCBI chr 7:94,759,076...94,774,787
Ensembl chr 7:94,758,800...94,774,569
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Endod1
endonuclease domain containing 1
multiple interactions
ISO
pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]
CTD
PMID:27542212
NCBI chr 8:12,898,430...12,928,156
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Hbp1
HMG-box transcription factor 1
multiple interactions
ISO
pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]
CTD
PMID:27542212
NCBI chr 6:51,231,479...51,257,699
Ensembl chr 6:51,231,480...51,257,625
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Hey1
hes-related family bHLH transcription factor with YRPW motif 1
multiple interactions
ISO
pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]
CTD
PMID:27542212
NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
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Il6r
interleukin 6 receptor
decreases expression
ISO
pyrvinium results in decreased expression of IL6R protein modified form
CTD
PMID:20116850
NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
pyrvinium results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
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Kmt2a
lysine methyltransferase 2A
multiple interactions
ISO
pyrvinium inhibits the reaction [KMT2A protein results in decreased susceptibility to molibresib]
CTD
PMID:26367796
NCBI chr 8:49,110,407...49,185,872
Ensembl chr 8:49,114,990...49,158,971
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
ISO
pyrvinium results in decreased expression of MYC mRNA
CTD
PMID:21170416
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
multiple interactions
ISO
pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CXCL8 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of TGFA mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA]
CTD
PMID:27542212
NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
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Ppp2r1b
protein phosphatase 2 scaffold subunit A beta
multiple interactions
ISO
pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA]
CTD
PMID:27542212
NCBI chr 8:55,279,278...55,311,768
Ensembl chr 8:55,279,373...55,301,320
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Rps6
ribosomal protein S6
decreases phosphorylation affects phosphorylation
ISO
pyrvinium results in decreased phosphorylation of RPS6 protein pyrvinium affects the phosphorylation of RPS6 protein
CTD
PMID:27542212
NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
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Rps6kb1
ribosomal protein S6 kinase B1
decreases phosphorylation
ISO
pyrvinium results in decreased phosphorylation of RPS6KB1 protein
CTD
PMID:27542212
NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
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Tgfa
transforming growth factor alpha
multiple interactions
ISO
pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of TGFA mRNA]
CTD
PMID:27542212
NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
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Vegfa
vascular endothelial growth factor A
decreases expression
ISO
pyrvinium results in decreased expression of VEGFA protein
CTD
PMID:20116850
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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Vim
vimentin
multiple interactions
ISO
pyrvinium inhibits the reaction [belinostat results in increased expression of VIM protein]
CTD
PMID:23671600
NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
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Wnt7a
Wnt family member 7A
decreases activity
ISO
pyrvinium results in decreased activity of WNT7A protein
CTD
PMID:25174399
NCBI chr 4:122,994,425...123,040,609
Ensembl chr 4:122,994,425...123,040,609
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Wwtr1
WW domain containing transcription regulator 1
multiple interactions
ISO
pyrvinium inhibits the reaction [belinostat results in increased expression of WWTR1 protein]
CTD
PMID:23671600
NCBI chr 2:147,577,149...147,693,033
Ensembl chr 2:147,577,089...147,693,082
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