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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrvinium
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Accession:CHEBI:8687 term browser browse the term
Definition:A quinolinium ion that is 1-methylquinolinium substituted by dimethylamino group at position 6 and a (E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl at position 2. It is a anthelminthic drug active against pinworms. The salts of pyrvinium can also be used as anticancer agents.
Synonyms:exact_synonym: 6-(dimethylamino)-2-[(E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methylquinolinium
 related_synonym: Formula=C26H28N3;   InChI=1S/C26H28N3/c1-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5/h6-18H,1-5H3/q+1;   InChIKey=QMHSXPLYMTVAMK-UHFFFAOYSA-N;   SMILES=CN(C)c1ccc2[n+](C)c(\\C=C\\c3cc(C)n(c3C)-c3ccccc3)ccc2c1
 xref: CAS:7187-62-4;   Drug_Central:2335;   KEGG:C07412
 xref_mesh: MESH:C024631
 xref: PMID:22332749;   Patent:GB834990;   Reaxys:4159167;   Wikipedia:Pyrvinium



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pyrvinium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO pyrvinium results in decreased phosphorylation of AKT1 protein CTD PMID:27542212 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Axin2 axin 2 decreases expression ISO pyrvinium results in decreased expression of AXIN2 mRNA CTD PMID:21170416 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO pyrvinium results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccne2 cyclin E2 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA] CTD PMID:27542212 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA] CTD PMID:27542212 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA] CTD PMID:27542212 NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 decreases activity ISO pyrvinium results in decreased activity of CSNK1A1 protein CTD PMID:21170416 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 decreases expression ISO pyrvinium results in decreased expression of DKK1 mRNA CTD PMID:21170416 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
G Dscc1 DNA replication and sister chromatid cohesion 1 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA] CTD PMID:27542212 NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212
JBrowse link
G Endod1 endonuclease domain containing 1 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA] CTD PMID:27542212 NCBI chr 8:11,209,123...11,238,680 JBrowse link
G Hbp1 HMG-box transcription factor 1 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA] CTD PMID:27542212 NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA] CTD PMID:27542212 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO pyrvinium results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO pyrvinium results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kmt2a lysine methyltransferase 2A multiple interactions ISO pyrvinium inhibits the reaction [KMT2A protein results in decreased susceptibility to molibresib] CTD PMID:26367796 NCBI chr 8:45,116,771...45,193,320
Ensembl chr 8:45,118,814...45,193,181
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO pyrvinium results in decreased expression of MYC mRNA CTD PMID:21170416 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CXCL8 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of TGFA mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA] CTD PMID:27542212 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA] CTD PMID:27542212 NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
affects phosphorylation
ISO pyrvinium results in decreased phosphorylation of RPS6 protein
pyrvinium affects the phosphorylation of RPS6 protein
CTD PMID:27542212 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO pyrvinium results in decreased phosphorylation of RPS6KB1 protein CTD PMID:27542212 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of TGFA mRNA] CTD PMID:27542212 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO pyrvinium results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin multiple interactions ISO pyrvinium inhibits the reaction [belinostat results in increased expression of VIM protein] CTD PMID:23671600 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wnt7a Wnt family member 7A decreases activity ISO pyrvinium results in decreased activity of WNT7A protein CTD PMID:25174399 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981
JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 multiple interactions ISO pyrvinium inhibits the reaction [belinostat results in increased expression of WWTR1 protein] CTD PMID:23671600 NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968
JBrowse link

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  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            antineoplastic agent 17359
              pyrvinium 25
Path 2
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  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      p-block molecular entity 19698
                        carbon group molecular entity 19619
                          organic molecular entity 19609
                            organic ion 9167
                              organic cation 8100
                                quinolinium ion 33
                                  pyrvinium 25
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