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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrvinium
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Accession:CHEBI:8687 term browser browse the term
Definition:A quinolinium ion that is 1-methylquinolinium substituted by dimethylamino group at position 6 and a (E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl at position 2. It is a anthelminthic drug active against pinworms. The salts of pyrvinium can also be used as anticancer agents.
Synonyms:exact_synonym: 6-(dimethylamino)-2-[(E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methylquinolinium
 related_synonym: Formula=C26H28N3;   InChI=1S/C26H28N3/c1-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5/h6-18H,1-5H3/q+1;   InChIKey=QMHSXPLYMTVAMK-UHFFFAOYSA-N;   SMILES=CN(C)c1ccc2[n+](C)c(\\C=C\\c3cc(C)n(c3C)-c3ccccc3)ccc2c1
 xref: CAS:7187-62-4;   Drug_Central:2335;   KEGG:C07412
 xref_mesh: MESH:C024631
 xref: PMID:22332749;   Patent:GB834990;   Reaxys:4159167;   Wikipedia:Pyrvinium

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pyrvinium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO pyrvinium results in decreased phosphorylation of AKT1 protein CTD PMID:27542212 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Axin2 axin 2 decreases expression ISO pyrvinium results in decreased expression of AXIN2 mRNA CTD PMID:21170416 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO pyrvinium results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccne2 cyclin E2 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA] CTD PMID:27542212 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406 		JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA] CTD PMID:27542212 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068 		JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA] CTD PMID:27542212 NCBI chr16:22,704,318...23,075,071
Ensembl chr16:22,979,444...23,074,798 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 decreases activity ISO pyrvinium results in decreased activity of CSNK1A1 protein CTD PMID:21170416 NCBI chr18:56,887,722...56,910,610
Ensembl chr18:56,887,354...56,918,345 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 decreases expression ISO pyrvinium results in decreased expression of DKK1 mRNA CTD PMID:21170416 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607 		JBrowse link
G Dscc1 DNA replication and sister chromatid cohesion 1 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA] CTD PMID:27542212 NCBI chr 7:94,759,076...94,774,787
Ensembl chr 7:94,758,800...94,774,569 		JBrowse link
G Endod1 endonuclease domain containing 1 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA] CTD PMID:27542212 NCBI chr 8:12,898,430...12,928,156 JBrowse link
G Hbp1 HMG-box transcription factor 1 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA] CTD PMID:27542212 NCBI chr 6:51,231,479...51,257,699
Ensembl chr 6:51,231,480...51,257,625 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA] CTD PMID:27542212 NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO pyrvinium results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO pyrvinium results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Kmt2a lysine methyltransferase 2A multiple interactions ISO pyrvinium inhibits the reaction [KMT2A protein results in decreased susceptibility to molibresib] CTD PMID:26367796 NCBI chr 8:49,110,407...49,185,872
Ensembl chr 8:49,114,990...49,158,971 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO pyrvinium results in decreased expression of MYC mRNA CTD PMID:21170416 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CXCL8 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of TGFA mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA] CTD PMID:27542212 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454 		JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA] CTD PMID:27542212 NCBI chr 8:55,279,278...55,311,768
Ensembl chr 8:55,279,373...55,301,320 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
affects phosphorylation		 ISO pyrvinium results in decreased phosphorylation of RPS6 protein
pyrvinium affects the phosphorylation of RPS6 protein		 CTD PMID:27542212 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO pyrvinium results in decreased phosphorylation of RPS6KB1 protein CTD PMID:27542212 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of TGFA mRNA] CTD PMID:27542212 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO pyrvinium results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vim vimentin multiple interactions ISO pyrvinium inhibits the reaction [belinostat results in increased expression of VIM protein] CTD PMID:23671600 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212 		JBrowse link
G Wnt7a Wnt family member 7A decreases activity ISO pyrvinium results in decreased activity of WNT7A protein CTD PMID:25174399 NCBI chr 4:122,994,425...123,040,609
Ensembl chr 4:122,994,425...123,040,609 		JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 multiple interactions ISO pyrvinium inhibits the reaction [belinostat results in increased expression of WWTR1 protein] CTD PMID:23671600 NCBI chr 2:147,577,149...147,693,033
Ensembl chr 2:147,577,089...147,693,082 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      application 19465
        pharmaceutical 19338
          drug 19338
            antineoplastic agent 17009
              pyrvinium 25
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Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      p-block molecular entity 19732
                        carbon group molecular entity 19636
                          organic molecular entity 19625
                            organic ion 8402
                              organic cation 7250
                                quinolinium ion 32
                                  pyrvinium 25
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