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ONTOLOGY REPORT - ANNOTATIONS


Term:pyrvinium
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Accession:CHEBI:8687 term browser browse the term
Definition:A quinolinium ion that is 1-methylquinolinium substituted by dimethylamino group at position 6 and a (E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl at position 2. It is a anthelminthic drug active against pinworms. The salts of pyrvinium can also be used as anticancer agents.
Synonyms:exact_synonym: 6-(dimethylamino)-2-[(E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methylquinolinium
 related_synonym: Formula=C26H28N3;   InChI=1S/C26H28N3/c1-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5/h6-18H,1-5H3/q+1;   InChIKey=QMHSXPLYMTVAMK-UHFFFAOYSA-N;   SMILES=CN(C)c1ccc2[n+](C)c(\\C=C\\c3cc(C)n(c3C)-c3ccccc3)ccc2c1
 xref: CAS:7187-62-4 "ChemIDplus";   CAS:7187-62-4 "KEGG COMPOUND";   Drug_Central:2335 "DrugCentral";   KEGG:C07412
 xref_mesh: MESH:C024631
 xref: PMID:22332749 "Europe PMC";   Patent:GB834990;   Reaxys:4159167 "Reaxys";   Wikipedia:Pyrvinium


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pyrvinium term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccne2 cyclin E2 JBrowse link 5 24,434,077 24,446,406 RGD:6480464
G Ccng2 cyclin G2 JBrowse link 14 16,267,572 16,276,068 RGD:6480464
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 JBrowse link 16 22,704,318 23,075,071 RGD:6480464
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:6480464
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:6480464
G Dscc1 DNA replication and sister chromatid cohesion 1 JBrowse link 7 94,759,076 94,774,787 RGD:6480464
G Endod1 endonuclease domain containing 1 JBrowse link 8 12,898,430 12,928,156 RGD:6480464
G Hbp1 HMG-box transcription factor 1 JBrowse link 6 51,231,479 51,257,699 RGD:6480464
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:6480464
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Kmt2a lysine methyltransferase 2A JBrowse link 8 49,110,407 49,185,872 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6480464
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta JBrowse link 8 55,279,278 55,311,768 RGD:6480464
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464
G Wnt7a Wnt family member 7A JBrowse link 4 122,994,425 123,040,609 RGD:6480464
G Wwtr1 WW domain containing transcription regulator 1 JBrowse link 2 147,577,149 147,693,033 RGD:6480464

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            antineoplastic agent 16555
              pyrvinium 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      p-block molecular entity 19545
                        carbon group molecular entity 19428
                          organic molecular entity 19420
                            organic ion 7845
                              organic cation 7068
                                quinolinium ion 32
                                  pyrvinium 25
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.