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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrvinium
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Accession:CHEBI:8687 term browser browse the term
Definition:A quinolinium ion that is 1-methylquinolinium substituted by dimethylamino group at position 6 and a (E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl at position 2. It is a anthelminthic drug active against pinworms. The salts of pyrvinium can also be used as anticancer agents.
Synonyms:exact_synonym: 6-(dimethylamino)-2-[(E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methylquinolinium
 related_synonym: Formula=C26H28N3;   InChI=1S/C26H28N3/c1-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5/h6-18H,1-5H3/q+1;   InChIKey=QMHSXPLYMTVAMK-UHFFFAOYSA-N;   SMILES=CN(C)c1ccc2[n+](C)c(\\C=C\\c3cc(C)n(c3C)-c3ccccc3)ccc2c1
 xref: CAS:7187-62-4;   Drug_Central:2335;   KEGG:C07412
 xref_mesh: MESH:C024631
 xref: PMID:22332749;   Patent:GB834990;   Reaxys:4159167;   Wikipedia:Pyrvinium


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pyrvinium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO pyrvinium results in decreased phosphorylation of AKT1 protein CTD PMID:27542212 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Axin2 axin 2 decreases expression ISO pyrvinium results in decreased expression of AXIN2 mRNA CTD PMID:21170416 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO pyrvinium results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccne2 cyclin E2 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA] CTD PMID:27542212 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA] CTD PMID:27542212 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA] CTD PMID:27542212 NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 decreases activity ISO pyrvinium results in decreased activity of CSNK1A1 protein CTD PMID:21170416 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 decreases expression ISO pyrvinium results in decreased expression of DKK1 mRNA CTD PMID:21170416 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Dscc1 DNA replication and sister chromatid cohesion 1 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA] CTD PMID:27542212 NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212 		JBrowse link
G Endod1 endonuclease domain containing 1 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA] CTD PMID:27542212 NCBI chr 8:11,209,123...11,238,680 JBrowse link
G Hbp1 HMG-box transcription factor 1 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA] CTD PMID:27542212 NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA] CTD PMID:27542212 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO pyrvinium results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO pyrvinium results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kmt2a lysine methyltransferase 2A multiple interactions ISO pyrvinium inhibits the reaction [KMT2A protein results in decreased susceptibility to molibresib] CTD PMID:26367796 NCBI chr 8:45,116,771...45,193,320
Ensembl chr 8:45,118,814...45,193,181 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO pyrvinium results in decreased expression of MYC mRNA CTD PMID:21170416 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of CXCL8 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of TGFA mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]; pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA] CTD PMID:27542212 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA] CTD PMID:27542212 NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
affects phosphorylation		 ISO pyrvinium results in decreased phosphorylation of RPS6 protein
pyrvinium affects the phosphorylation of RPS6 protein		 CTD PMID:27542212 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO pyrvinium results in decreased phosphorylation of RPS6KB1 protein CTD PMID:27542212 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of TGFA mRNA] CTD PMID:27542212 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO pyrvinium results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin multiple interactions ISO pyrvinium inhibits the reaction [belinostat results in increased expression of VIM protein] CTD PMID:23671600 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Wnt7a Wnt family member 7A decreases activity ISO pyrvinium results in decreased activity of WNT7A protein CTD PMID:25174399 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981 		JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 multiple interactions ISO pyrvinium inhibits the reaction [belinostat results in increased expression of WWTR1 protein] CTD PMID:23671600 NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968 		JBrowse link
Term paths to the root
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  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            antineoplastic agent 17359
              pyrvinium 25
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Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      p-block molecular entity 19698
                        carbon group molecular entity 19619
                          organic molecular entity 19609
                            organic ion 9167
                              organic cation 8100
                                quinolinium ion 33
                                  pyrvinium 25
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