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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrimethanil
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Accession:CHEBI:8674 term browser browse the term
Definition:A member of the class of aminopyrimidines that is N-phenylpyrimidin-2-amine carrying two additional methyl substituents at positions 4 and 6. A fungicide used to control grey mould on fruit, vegetables and ornamentals as well as leaf scab on pome fruit. Also commonly employed to control Botrytis cinerea throughout the winemaking process in grapes, must, fermenting must and wine.
Synonyms:exact_synonym: 4,6-dimethyl-N-phenylpyrimidin-2-amine
 related_synonym: 2-Anilino-4,6-dimethylpyrimidine;   4,6-Dimethyl-N-phenyl-2-pyrimidinamine;   Formula=C12H13N3;   InChI=1S/C12H13N3/c1-9-8-10(2)14-12(13-9)15-11-6-4-3-5-7-11/h3-8H,1-2H3,(H,13,14,15);   InChIKey=ZLIBICFPKPWGIZ-UHFFFAOYSA-N;   N-(4,6-dimethylpyrimidin-2-yl)aniline;   SMILES=Cc1cc(C)nc(Nc2ccccc2)n1
 xref: CAS:53112-28-0;   HMDB:HMDB0033135;   KEGG:C11180
 xref_mesh: MESH:C108337
 xref: PMID:22949075;   PMID:23246620;   PMID:23258318;   PMID:23410121;   PMID:23436777;   PMID:23673061;   PMID:23993516;   PMID:24081744;   PMID:24365971;   PMID:24380616;   PMID:24652239;   PMID:24835131;   PMID:25145229;   PMID:25216469;   PPDB:573;   Pesticides:pyrimethanil;   Reaxys:151589;   Wikipedia:Pyrimethanil


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pyrimethanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO pyrimethanil binds to and results in increased activity of AHR protein CTD PMID:23436777 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of AIF1 protein]
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of AIF1 protein
CTD PMID:31939705 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G App amyloid beta precursor protein affects binding
multiple interactions
ISO pyrimethanil binds to APP protein modified form
[APP gene mutant form results in increased expression of APP protein modified form] which results in increased susceptibility to pyrimethanil; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of AIF1 protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of GFAP protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL1B protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL6 protein]; APP protein modified form results in increased susceptibility to [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil]
CTD PMID:31939705 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor increases expression
multiple interactions
ISO pyrimethanil results in increased expression of AR mRNA
pyrimethanil inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]
CTD PMID:21310686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of BACE1 protein CTD PMID:31939705 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Casp3 caspase 3 multiple interactions
affects expression
ISO [pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of CASP3 mRNA
pyrimethanil affects the expression of CASP3 mRNA
CTD PMID:22880100 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of GFAP protein]
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of GFAP protein
CTD PMID:31939705 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gpx1 glutathione peroxidase 1 affects expression
multiple interactions
ISO pyrimethanil affects the expression of GPX1 mRNA
[pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of GPX1 mRNA
CTD PMID:22880100 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL1B protein] CTD PMID:31939705 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL6 protein] CTD PMID:31939705 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [pyrimethanil binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19770
    role 19718
      biological role 19717
        xenobiotic 18379
          pyrimethanil 12
Path 2
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  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic molecule 19461
                              organic cyclic compound 19232
                                organic heterocyclic compound 18404
                                  organic heteromonocyclic compound 16430
                                    diazines 12137
                                      pyrimidines 11954
                                        pyrimidine antifungal agent 70
                                          pyrimidine fungicide 67
                                            anilinopyrimidine fungicide 22
                                              pyrimethanil 12
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