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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrimethanil
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Accession:CHEBI:8674 term browser browse the term
Definition:A member of the class of aminopyrimidines that is N-phenylpyrimidin-2-amine carrying two additional methyl substituents at positions 4 and 6. A fungicide used to control grey mould on fruit, vegetables and ornamentals as well as leaf scab on pome fruit. Also commonly employed to control Botrytis cinerea throughout the winemaking process in grapes, must, fermenting must and wine.
Synonyms:exact_synonym: 4,6-dimethyl-N-phenylpyrimidin-2-amine
 related_synonym: 2-Anilino-4,6-dimethylpyrimidine;   4,6-Dimethyl-N-phenyl-2-pyrimidinamine;   Formula=C12H13N3;   InChI=1S/C12H13N3/c1-9-8-10(2)14-12(13-9)15-11-6-4-3-5-7-11/h3-8H,1-2H3,(H,13,14,15);   InChIKey=ZLIBICFPKPWGIZ-UHFFFAOYSA-N;   N-(4,6-dimethylpyrimidin-2-yl)aniline;   SMILES=Cc1cc(C)nc(Nc2ccccc2)n1
 xref: CAS:53112-28-0;   HMDB:HMDB0033135;   KEGG:C11180
 xref_mesh: MESH:C108337
 xref: PMID:22949075;   PMID:23246620;   PMID:23258318;   PMID:23410121;   PMID:23436777;   PMID:23673061;   PMID:23993516;   PMID:24081744;   PMID:24365971;   PMID:24380616;   PMID:24652239;   PMID:24835131;   PMID:25145229;   PMID:25216469;   PPDB:573;   Pesticides:pyrimethanil;   Reaxys:151589;   Wikipedia:Pyrimethanil



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pyrimethanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO pyrimethanil binds to and results in increased activity of AHR protein CTD PMID:23436777 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of AIF1 protein]
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of AIF1 protein
CTD PMID:31939705 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G App amyloid beta precursor protein affects binding
multiple interactions
ISO pyrimethanil binds to APP protein modified form
[APP gene mutant form results in increased expression of APP protein modified form] which results in increased susceptibility to pyrimethanil; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of AIF1 protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of GFAP protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL1B protein]; [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL6 protein]; APP protein modified form results in increased susceptibility to [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil]
CTD PMID:31939705 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Ar androgen receptor increases expression
multiple interactions
ISO pyrimethanil results in increased expression of AR mRNA
pyrimethanil inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]
CTD PMID:21310686 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of BACE1 protein CTD PMID:31939705 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Casp3 caspase 3 multiple interactions
affects expression
ISO [pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of CASP3 mRNA
pyrimethanil affects the expression of CASP3 mRNA
CTD PMID:22880100 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esr1 estrogen receptor 1 increases activity EXP pyrimethanil results in increased activity of ESR1 protein CTD PMID:33352482 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of GFAP protein]
[cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] results in increased expression of GFAP protein
CTD PMID:31939705 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gpx1 glutathione peroxidase 1 affects expression
multiple interactions
ISO pyrimethanil affects the expression of GPX1 mRNA
[pyrimethanil co-treated with cyprodinil co-treated with fludioxonil] results in increased expression of GPX1 mRNA
CTD PMID:22880100 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL1B protein] CTD PMID:31939705 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [cyprodinil co-treated with mepanipyrim co-treated with pyrimethanil] promotes the reaction [[APP gene mutant form results in increased expression of APP protein modified form] which results in increased expression of IL6 protein] CTD PMID:31939705 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO pyrimethanil results in increased expression of NRF1 mRNA CTD PMID:33352482 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [pyrimethanil binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO pyrimethanil results in increased expression of TFF1 mRNA CTD PMID:33352482 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        xenobiotic 18699
          pyrimethanil 16
Path 2
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  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  organic heteromonocyclic compound 17151
                                    diazines 12358
                                      pyrimidines 12189
                                        pyrimidine antifungal agent 80
                                          pyrimidine fungicide 77
                                            anilinopyrimidine fungicide 30
                                              pyrimethanil 16
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