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ONTOLOGY REPORT - ANNOTATIONS


Term:pyrimethamine
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Accession:CHEBI:8673 term browser browse the term
Definition:An aminopyrimidine that is pyrimidine-2,4-diamine which is substituted at position 5 by a p-chlorophenyl group and at position 6 by an ethyl group. It is a folic acid antagonist used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
Synonyms:exact_synonym: 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
 related_synonym: 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;   2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine;   2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine;   5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine;   5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine;   CD;   Chloridine;   Chloridyn;   Diaminopyritamin;   Ethylpyrimidine;   Formula=C12H13ClN4;   InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17);   InChIKey=WKSAUQYGYAYLPV-UHFFFAOYSA-N;   Primethamine;   SMILES=CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1;   pirimetamina;   pyrimethaminum
 xref: Beilstein:219864 "Beilstein";   CAS:58-14-0 "ChemIDplus";   CAS:58-14-0 "KEGG COMPOUND";   CAS:58-14-0 "NIST Chemistry WebBook";   DrugBank:DB00205;   HMDB:HMDB0014350;   KEGG:C07391;   KEGG:D00488;   LINCS:LSM-3967
 xref_mesh: MESH:D011739
 xref: PDBeChem:CP6;   PMID:11257045 "Europe PMC";   PMID:11313656 "Europe PMC";   PMID:12543697 "Europe PMC";   PMID:16157660 "Europe PMC";   PMID:19435820 "Europe PMC";   PMID:28166217 "Europe PMC";   PMID:3377143 "Europe PMC";   Reaxys:219864 "Reaxys";   VSDB:1912;   Wikipedia:Pyrimethamine


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pyrimethamine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:6480464
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 JBrowse link 1 257,676,172 258,004,428 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gpx4 glutathione peroxidase 4 JBrowse link 7 12,516,357 12,519,154 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G Hexb hexosaminidase subunit beta JBrowse link 2 27,983,925 28,003,260 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Slc46a1 solute carrier family 46 member 1 JBrowse link 10 65,728,508 65,741,708 RGD:6480464
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:6480464
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19596
    role 19539
      biological role 19537
        antimicrobial agent 17048
          antimicrobial drug 5999
            antiprotozoal drug 3665
              pyrimethamine 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19596
    subatomic particle 19592
      composite particle 19592
        hadron 19592
          baryon 19592
            nucleon 19592
              atomic nucleus 19592
                atom 19592
                  main group element atom 19471
                    main group molecular entity 19471
                      s-block molecular entity 19244
                        hydrogen molecular entity 19234
                          hydrides 18152
                            inorganic hydride 17088
                              pnictogen hydride 17046
                                nitrogen hydride 16867
                                  azane 16546
                                    ammonia 16543
                                      organic amino compound 16542
                                        aromatic amine 13541
                                          aminopyrimidine 1026
                                            pyrimethamine 18
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