The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
An aminopyrimidine that is pyrimidine-2,4-diamine which is substituted at position 5 by a p-chlorophenyl group and at position 6 by an ethyl group. It is a folic acid antagonist used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
Leucovorin inhibits the reaction [Pyrimethamine inhibits the reaction [Oncostatin M results in increased expression of BCL6 mRNA]]; Pyrimethamine inhibits the reaction [Oncostatin M results in increased expression of BCL6 mRNA]
[Pyrimethamine co-treated with temozolomide] results in increased cleavage of CASP3 protein; Palmitic Acid promotes the reaction [Pyrimethamine results in increased activity of CASP3 protein]
Pyrimethamine binds to and results in increased stability of DHFR protein; Pyrimethamine results in increased expression of and affects the activity of DHFR protein
Pyrimethamine results in decreased activity of GSTP1 protein Pyrimethamine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]
Pyrimethamine analog inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Pyrimethamine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Pyrimethamine inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin]; Pyrimethamine inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium] Pyrimethamine results in decreased activity of SLC47A1 protein
Pyrimethamine analog inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Pyrimethamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Pyrimethamine inhibits the reaction [SLC47A2 protein results in increased uptake of Tetraethylammonium] Pyrimethamine results in decreased activity of SLC47A2 protein