Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

go back to main search page
Accession:CHEBI:8654 term browser browse the term
Definition:A carboxamidine that is 1,4,5,6-tetrahydropyrimidine that is substituted at position 1 by a methyl group and at position 2 by an (E)-2-(2-thienyl)vinyl group. It is used, particularly as the embonate [4,4'-methylenebis(3-hydroxy-2-naphthoate)] salt, as an anthelmintic that is effective against intestinal nematodes including threadworms, roundworms and hookworms, and is included in the WHO 'Model List of Essential Medicines'.
Synonyms:exact_synonym: 1-methyl-2-[(E)-2-(2-thienyl)vinyl]-1,4,5,6-tetrahydropyrimidine
 related_synonym: Formula=C11H14N2S;   InChI=1S/C11H14N2S/c1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h2,4-6,9H,3,7-8H2,1H3/b6-5+;   InChIKey=YSAUAVHXTIETRK-AATRIKPKSA-N;   SMILES=CN1CCCN=C1\\C=C\\c1cccs1;   pirantel;   pyrantelum
 xref: CAS:15686-83-6;   Drug_Central:2999;   KEGG:C07409;   KEGG:D08451
 xref_mesh: MESH:D011715
 xref: PMID:20307935;   PMID:21689886;   PMID:2619378;   PMID:5124439;   PMID:552733;   PMID:7402460;   Patent:BE658987;   Patent:US3502661;   Reaxys:518505;   Wikipedia:Pyrantel

show annotations for term's descendants           Sort by:
pyrantel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Pyrantel CTD PMID:12920490 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO Pyrantel results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      application 19465
        pesticide 16525
          nematicide 3324
            antinematodal drug 482
              pyrantel 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic molecule 19556
                              organic cyclic compound 19365
                                organic heterocyclic compound 18486
                                  organonitrogen heterocyclic compound 17559
                                    tetrahydropyrimidine 2
                                      1,4,5,6-tetrahydropyrimidines 2
                                        pyrantel 2
paths to the root