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G |
Ahr |
aryl-hydrocarbon receptor |
increases expression multiple interactions |
EXP ISO |
Pyocyanine results in increased expression of AHR mRNA Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter] |
CTD |
PMID:28476168 PMID:31078726 |
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NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
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G |
Akt1 |
thymoma viral proto-oncogene 1 |
multiple interactions increases phosphorylation |
ISO |
Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:24015256 |
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NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
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G |
Atf6 |
activating transcription factor 6 |
increases activity |
ISO |
Pyocyanine results in increased activity of ATF6 protein |
CTD |
PMID:27613716 |
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NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
decreases expression |
EXP |
Pyocyanine results in decreased expression of CCL5 mRNA; Pyocyanine results in decreased expression of CCL5 protein |
CTD |
PMID:31078726 |
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NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
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G |
Ctnnb1 |
catenin beta 1 |
increases expression |
EXP |
Pyocyanine results in increased expression of CTNNB1 mRNA |
CTD |
PMID:31078726 |
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NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
EXP |
Pyocyanine results in increased expression of CYP1A1 mRNA |
CTD |
PMID:31078726 |
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NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
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G |
Egfr |
epidermal growth factor receptor |
increases phosphorylation |
ISO |
Pyocyanine results in increased phosphorylation of EGFR protein |
CTD |
PMID:24015256 |
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NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
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G |
Fabp4 |
fatty acid binding protein 4, adipocyte |
decreases expression |
EXP |
Pyocyanine results in decreased expression of FABP4 mRNA |
CTD |
PMID:31078726 |
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NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
ISO |
Pyocyanine results in increased expression of GCLC mRNA [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA] |
CTD |
PMID:24015256 |
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NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
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G |
Hsf1 |
heat shock factor 1 |
increases activity |
ISO |
Pyocyanine results in increased activity of HSF1 protein |
CTD |
PMID:27613716 |
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NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113
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G |
Il10 |
interleukin 10 |
increases expression |
EXP |
Pyocyanine results in increased expression of IL10 protein |
CTD |
PMID:31078726 |
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NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
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G |
Il13 |
interleukin 13 |
decreases expression |
EXP |
Pyocyanine results in decreased expression of IL13 protein |
CTD |
PMID:31078726 |
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NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
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G |
Il6 |
interleukin 6 |
increases expression |
EXP |
Pyocyanine results in increased expression of IL6 protein |
CTD |
PMID:31078726 |
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NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Map2k1 |
mitogen-activated protein kinase kinase 1 |
increases phosphorylation |
ISO |
Pyocyanine results in increased phosphorylation of MAP2K1 protein |
CTD |
PMID:24015256 |
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NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913
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G |
Map2k2 |
mitogen-activated protein kinase kinase 2 |
increases phosphorylation |
ISO |
Pyocyanine results in increased phosphorylation of MAP2K2 protein |
CTD |
PMID:24015256 |
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NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809
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G |
Mapk1 |
mitogen-activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24015256 PMID:24316274 |
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NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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G |
Mapk3 |
mitogen-activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO |
Pyocyanine results in increased phosphorylation of MAPK3 protein Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24015256 PMID:24316274 |
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NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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G |
Nfe2l2 |
nuclear factor, erythroid derived 2, like 2 |
multiple interactions increases activity |
ISO EXP |
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with RTKI cpd] inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein; RTKI cpd inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; trigonelline inhibits the reaction [Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein] Pyocyanine results in increased activity of NFE2L2 protein |
CTD |
PMID:24015256 PMID:27613716 |
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NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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G |
Nqo1 |
NAD(P)H dehydrogenase, quinone 1 |
increases expression multiple interactions |
ISO |
Pyocyanine results in increased expression of NQO1 mRNA [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of NQO1 mRNA] |
CTD |
PMID:24015256 |
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NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
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G |
Pparg |
peroxisome proliferator activated receptor gamma |
decreases expression |
EXP |
Pyocyanine results in decreased expression of PPARG mRNA |
CTD |
PMID:31078726 |
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NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
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G |
Tardbp |
TAR DNA binding protein |
multiple interactions |
ISO |
Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter] |
CTD |
PMID:28476168 |
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NCBI chr 4:148,696,839...148,711,672
Ensembl chr 4:148,696,839...148,711,476
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G |
Tnf |
tumor necrosis factor |
increases expression |
EXP |
Pyocyanine results in increased expression of TNF mRNA |
CTD |
PMID:31078726 |
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NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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