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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyocyanine
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Accession:CHEBI:8653 term browser browse the term
Definition:An iminium betaine that is 5-methylphenazin-5-ium which is substituted at position 1 by an oxidanidyl group. An antibiotic pigment produced by Pseudomonas aeruginosa.
Synonyms:exact_synonym: 5-methylphenazin-5-ium-1-olate
 related_synonym: Formula=C13H10N2O;   InChI=1S/C13H10N2O/c1-15-10-6-3-2-5-9(10)14-13-11(15)7-4-8-12(13)16/h2-8H,1H3;   InChIKey=YNCMLFHHXWETLD-UHFFFAOYSA-N;   SMILES=C[N+]1=C2C=CC=CC2=NC2=C1C=CC=C2[O-];   pyocyanin
 alt_id: CHEBI:137500
 xref: CAS:85-66-5;   Chemspider:6558;   KEGG:C01748
 xref_mesh: MESH:D011710
 xref: MetaCyc:CPD-12847;   PDBeChem:3J8;   PMID:21888766;   PMID:27322205;   PMID:27517959;   PMID:27559393;   PMID:27940577;   PMID:28333255;   PMID:28408162;   PMID:28558232;   PMID:28607159;   PMID:31647218;   PMID:31981486;   PMID:32417365;   PMID:32707314;   PMID:32763156;   PMID:33398400;   PMID:33545813;   PMID:33578646;   Reaxys:11862;   Wikipedia:Pyocyanin
 cyclic_relationship: is_conjugate_base_of CHEBI:62220



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pyocyanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor increases expression
multiple interactions
EXP
ISO
Pyocyanine results in increased expression of AHR mRNA
Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter]
CTD PMID:28476168 PMID:31078726 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
increases phosphorylation
ISO Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein] CTD PMID:24015256 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Atf6 activating transcription factor 6 increases activity ISO Pyocyanine results in increased activity of ATF6 protein CTD PMID:27613716 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression EXP Pyocyanine results in decreased expression of CCL5 mRNA; Pyocyanine results in decreased expression of CCL5 protein CTD PMID:31078726 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
G Ctnnb1 catenin beta 1 increases expression EXP Pyocyanine results in increased expression of CTNNB1 mRNA CTD PMID:31078726 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Pyocyanine results in increased expression of CYP1A1 mRNA CTD PMID:31078726 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation ISO Pyocyanine results in increased phosphorylation of EGFR protein CTD PMID:24015256 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte decreases expression EXP Pyocyanine results in decreased expression of FABP4 mRNA CTD PMID:31078726 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO Pyocyanine results in increased expression of GCLC mRNA
[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA]
CTD PMID:24015256 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Hsf1 heat shock factor 1 increases activity ISO Pyocyanine results in increased activity of HSF1 protein CTD PMID:27613716 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113
JBrowse link
G Il10 interleukin 10 increases expression EXP Pyocyanine results in increased expression of IL10 protein CTD PMID:31078726 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il13 interleukin 13 decreases expression EXP Pyocyanine results in decreased expression of IL13 protein CTD PMID:31078726 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
JBrowse link
G Il6 interleukin 6 increases expression EXP Pyocyanine results in increased expression of IL6 protein CTD PMID:31078726 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 increases phosphorylation ISO Pyocyanine results in increased phosphorylation of MAP2K1 protein CTD PMID:24015256 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913
JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 increases phosphorylation ISO Pyocyanine results in increased phosphorylation of MAP2K2 protein CTD PMID:24015256 NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
ISO Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein] CTD PMID:24015256 PMID:24316274 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Pyocyanine results in increased phosphorylation of MAPK3 protein
Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]
CTD PMID:24015256 PMID:24316274 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases activity
ISO
EXP
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with RTKI cpd] inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein; RTKI cpd inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; trigonelline inhibits the reaction [Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein]
Pyocyanine results in increased activity of NFE2L2 protein
CTD PMID:24015256 PMID:27613716 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression
multiple interactions
ISO Pyocyanine results in increased expression of NQO1 mRNA
[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of NQO1 mRNA]
CTD PMID:24015256 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma decreases expression EXP Pyocyanine results in decreased expression of PPARG mRNA CTD PMID:31078726 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter] CTD PMID:28476168 NCBI chr 4:148,696,839...148,711,672
Ensembl chr 4:148,696,839...148,711,476
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Pyocyanine results in increased expression of TNF mRNA CTD PMID:31078726 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link

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  CHEBI ontology 22188
    role 22173
      biological role 22172
        biophysical role 14202
          biological pigment 1127
            pyocyanine 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    main group molecular entity 22114
                      s-block molecular entity 21706
                        hydrogen molecular entity 21622
                          hydrides 20748
                            inorganic hydride 18678
                              pnictogen hydride 18658
                                nitrogen hydride 18537
                                  ammonium 8210
                                    ammonium ion derivative 8205
                                      quaternary ammonium ion 5406
                                        quaternary nitrogen compound 886
                                          iminium betaine 57
                                            pyocyanine 22
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