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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyocyanine
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Accession:CHEBI:8653 term browser browse the term
Definition:An iminium betaine that is 5-methylphenazin-5-ium which is substituted at position 1 by an oxidanidyl group. An antibiotic pigment produced by Pseudomonas aeruginosa.
Synonyms:exact_synonym: 5-methylphenazin-5-ium-1-olate
 related_synonym: Formula=C13H10N2O;   InChI=1S/C13H10N2O/c1-15-10-6-3-2-5-9(10)14-13-11(15)7-4-8-12(13)16/h2-8H,1H3;   InChIKey=YNCMLFHHXWETLD-UHFFFAOYSA-N;   SMILES=C[N+]1=C2C=CC=CC2=NC2=C1C=CC=C2[O-];   pyocyanin
 alt_id: CHEBI:137500
 xref: CAS:85-66-5;   Chemspider:6558;   KEGG:C01748
 xref_mesh: MESH:D011710
 xref: MetaCyc:CPD-12847;   PDBeChem:3J8;   PMID:21888766;   PMID:27322205;   PMID:27517959;   PMID:27559393;   PMID:27940577;   PMID:28333255;   PMID:28408162;   PMID:28558232;   PMID:28607159;   PMID:31647218;   PMID:31981486;   PMID:32417365;   PMID:32707314;   PMID:32763156;   PMID:33398400;   PMID:33545813;   PMID:33578646;   Reaxys:11862;   Wikipedia:Pyocyanin
 cyclic_relationship: is_conjugate_base_of CHEBI:62220



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pyocyanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression
multiple interactions
ISO Pyocyanine results in increased expression of AHR mRNA
Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter]
CTD PMID:28476168 PMID:31078726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein] CTD PMID:24015256 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atf6 activating transcription factor 6 increases activity EXP Pyocyanine results in increased activity of ATF6 protein CTD PMID:27613716 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Pyocyanine results in decreased expression of CCL5 mRNA; Pyocyanine results in decreased expression of CCL5 protein CTD PMID:31078726 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO Pyocyanine results in increased expression of CTNNB1 mRNA CTD PMID:31078726 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Pyocyanine results in increased expression of CYP1A1 mRNA CTD PMID:31078726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation ISO Pyocyanine results in increased phosphorylation of EGFR protein CTD PMID:24015256 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Pyocyanine results in decreased expression of FABP4 mRNA CTD PMID:31078726 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO Pyocyanine results in increased expression of GCLC mRNA
[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA]
CTD PMID:24015256 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity EXP Pyocyanine results in increased activity of HSF1 protein CTD PMID:27613716 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Il10 interleukin 10 increases expression ISO Pyocyanine results in increased expression of IL10 protein CTD PMID:31078726 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 decreases expression ISO Pyocyanine results in decreased expression of IL13 protein CTD PMID:31078726 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il6 interleukin 6 increases expression ISO Pyocyanine results in increased expression of IL6 protein CTD PMID:31078726 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases phosphorylation ISO Pyocyanine results in increased phosphorylation of MAP2K1 protein CTD PMID:24015256 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases phosphorylation ISO Pyocyanine results in increased phosphorylation of MAP2K2 protein CTD PMID:24015256 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein] CTD PMID:24015256 PMID:24316274 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Pyocyanine results in increased phosphorylation of MAPK3 protein
Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]
CTD PMID:24015256 PMID:24316274 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases activity
ISO
EXP
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with RTKI cpd] inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein; RTKI cpd inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; trigonelline inhibits the reaction [Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein]
Pyocyanine results in increased activity of NFE2L2 protein
CTD PMID:24015256 PMID:27613716 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO Pyocyanine results in increased expression of NQO1 mRNA
[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of NQO1 mRNA]
CTD PMID:24015256 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Pyocyanine results in decreased expression of PPARG mRNA CTD PMID:31078726 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter] CTD PMID:28476168 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Pyocyanine results in increased expression of TNF mRNA CTD PMID:31078726 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        biophysical role 14069
          biological pigment 1120
            pyocyanine 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    main group molecular entity 19866
                      s-block molecular entity 19698
                        hydrogen molecular entity 19684
                          hydrides 19159
                            inorganic hydride 18151
                              pnictogen hydride 18140
                                nitrogen hydride 18046
                                  ammonium 8317
                                    ammonium ion derivative 8312
                                      quaternary ammonium ion 5274
                                        quaternary nitrogen compound 854
                                          iminium betaine 56
                                            pyocyanine 22
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