CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: purpurin
Accession: CHEBI:8645
browse the term
Definition: A trihydroxyanthraquinone derived from anthracene by substitution with oxo groups at C-9 and C-10 and with hydroxy groups at C-1, C-2 and C-4.
Synonyms: exact_synonym: 1,2,4-trihydroxyanthracene-9,10-dione
related_synonym: 1,2,4-Trihydroxyanthrachinon; 1,2,4-trihydroxy-9,10-anthracenedione; 1,2,4-trihydroxy-9,10-anthraquinone; 1,2,4-trihydroxyanthra-9,10-quinone; 1,2,4-trihydroxyanthraquinone; Alizarin purpurin; C.I. 58205; Formula=C14H8O5; InChI=1S/C14H8O5/c15-8-5-9(16)14(19)11-10(8)12(17)6-3-1-2-4-7(6)13(11)18/h1-5,15-16,19H; InChIKey=BBNQQADTFFCFGB-UHFFFAOYSA-N; Pr; SMILES=Oc1cc(O)c2C(=O)c3ccccc3C(=O)c2c1O; hydroxylizaric acid; purpurine; smoke Brown G; verantin
xref: Beilstein:1887127; CAS:81-54-9; Gmelin:271628; KEGG:C10395; KNApSAcK:C00002857
xref_mesh: MESH:C410870
xref: PMID:10521685; PMID:14500876; PMID:19748496; PMID:20238054; PMID:20392152; PMID:20686243; PMID:21552598; PMID:22997839; PMID:23226409; PMID:23233879; PMID:26037779; PMID:26178874; Patent:CN101659793; Reaxys:1887127; Wikipedia:1\,2\,4-Trihydroxyanthraquinone
G
Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
ISO
purpurin results in decreased phosphorylation of AKT1 protein
CTD
PMID:33368780
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Alb
albumin
multiple interactions
EXP
purpurin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in decreased expression of ALB protein]
CTD
PMID:35838105
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
purpurin results in increased expression of BAX mRNA
CTD
PMID:33368780
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
purpurin results in decreased expression of BCL2 mRNA
CTD
PMID:33368780
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Casp3
caspase 3
increases expression
ISO
purpurin results in increased expression of CASP3 mRNA
CTD
PMID:33368780
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp9
caspase 9
increases expression
ISO
purpurin results in increased expression of CASP9 mRNA
CTD
PMID:33368780
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Cat
catalase
multiple interactions
EXP
purpurin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in decreased activity of CAT protein]
CTD
PMID:35838105
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccnd1
cyclin D1
decreases expression
ISO
purpurin results in decreased expression of CCND1 protein
CTD
PMID:33368780
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity increases expression increases activity
ISO
purpurin results in decreased activity of CYP1A1 protein purpurin results in increased expression of CYP1A1 mRNA purpurin results in increased activity of CYP1A1 protein
CTD
PMID:11502733 PMID:12379470 PMID:12744663
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases activity increases activity
ISO
purpurin results in decreased activity of CYP1A2 protein purpurin results in increased activity of CYP1A2 protein
CTD
PMID:12379470 PMID:12744663 PMID:33438235
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity increases expression
ISO
purpurin results in decreased activity of CYP1B1 protein purpurin results in increased expression of CYP1B1 mRNA
CTD
PMID:11502733 PMID:12379470
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
decreases activity
ISO
purpurin results in decreased activity of CYP2C9 protein
CTD
PMID:33438235
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
G
Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
decreases activity
ISO
purpurin results in decreased activity of CYP2C19 protein
CTD
PMID:33438235
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity multiple interactions
ISO EXP
purpurin results in decreased activity of CYP2E1 protein purpurin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased activity of CYP2E1 protein]
CTD
PMID:12379470 PMID:35838105
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Egfr
epidermal growth factor receptor
decreases expression
ISO
purpurin results in decreased expression of EGFR protein
CTD
PMID:33368780
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
G
G6pd
glucose-6-phosphate dehydrogenase
multiple interactions
EXP
purpurin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in decreased activity of G6PD protein]
CTD
PMID:35838105
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
EXP
purpurin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased expression of GPT protein]
CTD
PMID:35838105
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gsr
glutathione-disulfide reductase
multiple interactions
EXP
purpurin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in decreased activity of GSR protein]
CTD
PMID:35838105
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Hmox1
heme oxygenase 1
multiple interactions
EXP
purpurin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased activity of HMOX1 protein]
CTD
PMID:35838105
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
increases expression
ISO
purpurin results in increased expression of LHPP protein
CTD
PMID:33368780
NCBI chr 1:187,403,390...187,494,577
Ensembl chr 1:187,403,433...187,494,578
G
Por
cytochrome p450 oxidoreductase
multiple interactions increases activity
ISO
3-amino-1-methyl-5H-pyrido(4,3-b)indole promotes the reaction [purpurin results in increased activity of POR protein]
CTD
PMID:12744663
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all