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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:purpurin
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Accession:CHEBI:8645 term browser browse the term
Definition:A trihydroxyanthraquinone derived from anthracene by substitution with oxo groups at C-9 and C-10 and with hydroxy groups at C-1, C-2 and C-4.
Synonyms:exact_synonym: 1,2,4-trihydroxyanthracene-9,10-dione
 related_synonym: 1,2,4-Trihydroxyanthrachinon;   1,2,4-trihydroxy-9,10-anthracenedione;   1,2,4-trihydroxy-9,10-anthraquinone;   1,2,4-trihydroxyanthra-9,10-quinone;   1,2,4-trihydroxyanthraquinone;   Alizarin purpurin;   C.I. 58205;   Formula=C14H8O5;   InChI=1S/C14H8O5/c15-8-5-9(16)14(19)11-10(8)12(17)6-3-1-2-4-7(6)13(11)18/h1-5,15-16,19H;   InChIKey=BBNQQADTFFCFGB-UHFFFAOYSA-N;   Pr;   SMILES=Oc1cc(O)c2C(=O)c3ccccc3C(=O)c2c1O;   hydroxylizaric acid;   purpurine;   smoke Brown G;   verantin
 xref: Beilstein:1887127;   CAS:81-54-9;   Gmelin:271628;   KEGG:C10395;   KNApSAcK:C00002857
 xref_mesh: MESH:C410870
 xref: PMID:10521685;   PMID:14500876;   PMID:19748496;   PMID:20238054;   PMID:20392152;   PMID:20686243;   PMID:21552598;   PMID:22997839;   PMID:23226409;   PMID:23233879;   PMID:26037779;   PMID:26178874;   Patent:CN101659793;   Reaxys:1887127;   Wikipedia:1\,2\,4-Trihydroxyanthraquinone

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purpurin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO purpurin results in decreased phosphorylation of AKT1 protein CTD PMID:33368780 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO purpurin results in increased expression of BAX mRNA CTD PMID:33368780 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO purpurin results in decreased expression of BCL2 mRNA CTD PMID:33368780 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases expression ISO purpurin results in increased expression of CASP3 mRNA CTD PMID:33368780 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases expression ISO purpurin results in increased expression of CASP9 mRNA CTD PMID:33368780 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO purpurin results in decreased expression of CCND1 protein CTD PMID:33368780 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
increases activity		 ISO purpurin results in decreased activity of CYP1A1 protein
purpurin results in increased expression of CYP1A1 mRNA
purpurin results in increased activity of CYP1A1 protein		 CTD PMID:11502733 PMID:12379470 PMID:12744663 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases activity		 ISO purpurin results in decreased activity of CYP1A2 protein
purpurin results in increased activity of CYP1A2 protein		 CTD PMID:12379470 PMID:12744663 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
increases expression		 ISO purpurin results in decreased activity of CYP1B1 protein
purpurin results in increased expression of CYP1B1 mRNA		 CTD PMID:11502733 PMID:12379470 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity ISO purpurin results in increased activity of CYP2B1 protein CTD PMID:12744663 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO purpurin results in decreased activity of CYP2E1 protein CTD PMID:12379470 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO purpurin results in decreased expression of EGFR protein CTD PMID:33368780 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Lhpp phospholysine phosphohistidine inorganic pyrophosphate phosphatase increases expression ISO purpurin results in increased expression of LHPP protein CTD PMID:33368780 NCBI chr 1:187,403,390...187,494,577
Ensembl chr 1:187,403,433...187,494,578 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
increases activity		 ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole promotes the reaction [purpurin results in increased activity of POR protein] CTD PMID:12744663 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biophysical role 13092
          biological pigment 1062
            purpurin 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      ketone 16924
                                        cyclic ketone 15393
                                          quinone 8376
                                            acenoquinone 7507
                                              anthraquinone 476
                                                hydroxyanthraquinones 466
                                                  trihydroxyanthraquinone 212
                                                    purpurin 14
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