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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:puerarin
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Accession:CHEBI:8633 term browser browse the term
Definition:A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 7 and 4' and a beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage.
Synonyms:exact_synonym: (1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-8-yl]-D-glucitol
 related_synonym: Formula=C21H20O9;   InChI=1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1;   InChIKey=HKEAFJYKMMKDOR-VPRICQMDSA-N;   SMILES=OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)ccc2c1occ(-c1ccc(O)cc1)c2=O
 xref: CAS:3681-99-0;   KEGG:C10524;   KNApSAcK:C00006094
 xref_mesh: MESH:C033607
 xref: PMID:25310912;   PMID:25553536;   Reaxys:64198


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puerarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACA mRNA] CTD PMID:31273855 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acacb acetyl-CoA carboxylase beta multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACB mRNA] CTD PMID:31273855 NCBI chr12:48,127,149...48,238,969
Ensembl chr12:48,127,149...48,238,887
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO puerarin results in increased expression of ACADM mRNA CTD PMID:31273855 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO puerarin inhibits the reaction [lead acetate results in decreased expression of ACHE protein] CTD PMID:23501611 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acly ATP citrate lyase increases expression ISO puerarin results in increased expression of ACLY mRNA CTD PMID:20706672 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO puerarin results in increased expression of ACOX1 mRNA CTD PMID:31273855 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACTA2 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:27318789, PMID:31273855 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO puerarin results in increased phosphorylation of AKT1 protein
fulvestrant inhibits the reaction [puerarin results in increased phosphorylation of AKT1 protein]
CTD PMID:21884717 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin multiple interactions EXP
ISO
puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of ALB protein] CTD PMID:23146695, PMID:23500774, PMID:27318789 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO puerarin results in increased expression of AQP1 mRNA CTD PMID:20706672 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression ISO puerarin results in increased expression of AQP3 mRNA CTD PMID:20706672 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Ar androgen receptor decreases expression ISO puerarin results in decreased expression of AR mRNA CTD PMID:20706672 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
puerarin results in increased expression of BAX protein
puerarin inhibits the reaction [cadmium acetate results in increased expression of BAX mRNA]; puerarin inhibits the reaction [cadmium acetate results in increased expression of BAX protein]
CTD PMID:16055262, PMID:27717697 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
puerarin results in decreased expression of BCL2 mRNA; puerarin results in decreased expression of BCL2 protein
puerarin inhibits the reaction [[Ethanol co-treated with Carbon Tetrachloride] results in increased expression of BCL2 mRNA]; puerarin inhibits the reaction [cadmium acetate results in decreased expression of BCL2 mRNA]; puerarin inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]
arsenic trioxide promotes the reaction [puerarin results in decreased expression of BCL2 mRNA]
CTD PMID:16055262, PMID:16426832, PMID:20416161, PMID:27717697 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [puerarin results in decreased expression of BIRC5 mRNA] CTD PMID:20416161 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
ISO
EXP
arsenic trioxide promotes the reaction [puerarin results in increased expression of CASP3 protein]
puerarin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]
puerarin results in increased activity of CASP3 protein
puerarin inhibits the reaction [cadmium acetate results in increased activity of CASP3 protein]; puerarin inhibits the reaction [lead nitrate results in increased activity of CASP3 protein]; puerarin results in decreased expression of and results in decreased activity of CASP3 protein
CTD PMID:16041641, PMID:16055262, PMID:20416161, PMID:24505050, PMID:27318789, PMID:27717697 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases expression
multiple interactions
ISO puerarin results in increased expression of CASP8 protein
arsenic trioxide promotes the reaction [puerarin results in increased expression of CASP8 protein]
CTD PMID:20416161 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase multiple interactions EXP puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT protein]; puerarin inhibits the reaction [lead nitrate results in decreased activity of CAT protein] CTD PMID:23315276, PMID:24975872 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of CTGF mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCN2 mRNA] CTD PMID:27318789, PMID:31273855 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cdh1 cadherin 1 increases expression ISO puerarin results in increased expression of CDH1 mRNA CTD PMID:20706672 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of COL1A1 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] CTD PMID:27318789, PMID:31273855 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein] CTD PMID:23500774 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO puerarin results in increased expression of CPT1A mRNA CTD PMID:31273855 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO puerarin inhibits the reaction [nickel sulfate results in increased phosphorylation of CREB1 protein] CTD PMID:26607348 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cygb cytoglobin decreases expression ISO puerarin results in decreased expression of CYGB mRNA CTD PMID:20706672 NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
ISO puerarin inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline]
puerarin results in increased expression of CYP2E1 protein
CTD PMID:18038910 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP puerarin affects the reaction [Lead affects the expression of CYP7A1] CTD PMID:22001170 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Dsg3 desmoglein 3 decreases expression ISO puerarin results in decreased expression of DSG3 mRNA CTD PMID:20706672 NCBI chr18:15,652,948...15,688,605
Ensembl chr18:15,650,526...15,688,284
JBrowse link
G Egf epidermal growth factor decreases expression ISO puerarin results in decreased expression of EGF mRNA CTD PMID:20706672 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases phosphorylation
EXP puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of EIF4EBP1 protein]
puerarin results in decreased phosphorylation of EIF4EBP1 protein
CTD PMID:27762461 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP puerarin results in decreased expression of ESR1 mRNA CTD PMID:22919047 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 decreases activity
decreases expression
ISO
EXP
puerarin results in decreased activity of ESR2 protein
puerarin results in decreased expression of ESR2 mRNA
CTD PMID:18937077, PMID:20706672, PMID:22919047 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO arsenic trioxide promotes the reaction [puerarin results in increased expression of FASLG protein] CTD PMID:20416161 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of FASN mRNA] CTD PMID:31273855 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO puerarin results in decreased expression of FBN1 mRNA CTD PMID:20706672 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Fbn2 fibrillin 2 decreases expression ISO puerarin results in decreased expression of FBN2 mRNA CTD PMID:20706672 NCBI chr18:53,068,495...53,272,254
Ensembl chr18:53,068,495...53,181,503
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO puerarin results in increased expression of FGF1 mRNA CTD PMID:20706672 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO puerarin results in increased expression of FOS mRNA CTD PMID:17142977 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [puerarin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein]]; puerarin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein] CTD PMID:27796870 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions
increases expression
ISO Sirolimus inhibits the reaction [puerarin results in increased expression of GPER1 protein] CTD PMID:27796870 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO puerarin inhibits the reaction [nickel sulfate results in increased activity of GPT protein] CTD PMID:26607348 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions
ISO
EXP
puerarin results in increased expression of GSR protein
puerarin inhibits the reaction [Lead results in decreased activity of GSR protein]
CTD PMID:18038910, PMID:22001170 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Has1 hyaluronan synthase 1 decreases expression ISO puerarin results in decreased expression of HAS1 mRNA CTD PMID:20706672 NCBI chr 1:59,720,612...59,732,409
Ensembl chr 1:59,720,612...59,732,409
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP puerarin affects the reaction [Lead affects the expression of HMGCR] CTD PMID:22001170 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
bisindolylmaleimide I inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; Cycloheximide inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; PRKCD mutant form inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [puerarin results in increased expression of HMOX1 protein]
puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 protein]
puerarin results in increased expression of HMOX1 mRNA; puerarin results in increased expression of HMOX1 protein
CTD PMID:20060010, PMID:24975872 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO puerarin results in increased expression of HSPB1 mRNA CTD PMID:20706672 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:21884717 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IFNG mRNA] CTD PMID:31273855 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression
multiple interactions
ISO puerarin results in decreased expression of IGF1 mRNA
puerarin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]
CTD PMID:20706672, PMID:23927877 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO puerarin results in decreased expression of IL1A mRNA CTD PMID:20706672 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IL1B mRNA] CTD PMID:31273855 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IL6 mRNA]; puerarin inhibits the reaction [nickel sulfate results in increased expression of IL6 protein] CTD PMID:26607348, PMID:31273855 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insr insulin receptor multiple interactions ISO puerarin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA] CTD PMID:23927877 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Kl Klotho decreases expression ISO puerarin results in decreased expression of KL mRNA CTD PMID:20706672 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP puerarin affects the reaction [Lead affects the expression of LDLR] CTD PMID:22001170 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lif LIF, interleukin 6 family cytokine decreases expression EXP puerarin results in decreased expression of LIF mRNA CTD PMID:22919047 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
puerarin results in increased phosphorylation of MAPK1 protein
puerarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein]
CTD PMID:21884717, PMID:24975872 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
puerarin results in increased phosphorylation of MAPK3 protein
puerarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK3 protein]
CTD PMID:21884717, PMID:24975872 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
increases expression
ISO arsenic trioxide promotes the reaction [puerarin results in increased expression of MAPK8 protein]
puerarin results in increased phosphorylation of MAPK8 protein
CTD PMID:20416161, PMID:21884717 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO puerarin results in increased phosphorylation of MAPK9 protein CTD PMID:21884717 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mc1r melanocortin 1 receptor decreases expression ISO puerarin results in decreased expression of MC1R mRNA CTD PMID:20706672 NCBI chr19:56,215,420...56,219,987 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP2 mRNA] CTD PMID:23500774 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression
multiple interactions
ISO
EXP
puerarin results in increased expression of COX1 mRNA
puerarin inhibits the reaction [lead nitrate results in decreased expression of COX1 mRNA]
CTD PMID:20706672, PMID:23315276 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions EXP puerarin inhibits the reaction [lead nitrate results in decreased expression of COX2 mRNA] CTD PMID:23315276 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III multiple interactions EXP puerarin inhibits the reaction [lead nitrate results in decreased expression of COX3 mRNA] CTD PMID:23315276 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases phosphorylation
ISO
EXP
Sirolimus inhibits the reaction [puerarin results in increased phosphorylation of MTOR protein]
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of MTOR protein]
CTD PMID:27762461, PMID:27796870 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO puerarin results in decreased expression of MYC protein CTD PMID:16055262 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects localization
EXP puerarin inhibits the reaction [Carbon Tetrachloride affects the localization of NFE2L2 protein]
puerarin affects the localization of NFE2L2 protein
CTD PMID:24975872 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP puerarin inhibits the reaction [Ethanol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to NFKB1 protein]]]; puerarin inhibits the reaction [Ethanol results in decreased activity of [NFKB1 protein binds to NFKB1 protein]]; puerarin inhibits the reaction [Ethanol results in increased activity of [RELA protein binds to NFKB1 protein]] CTD PMID:17887948 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO puerarin inhibits the reaction [Carbon Tetrachloride results in increased degradation of NFKBIA protein] CTD PMID:27318789 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO puerarin inhibits the reaction [lead acetate results in decreased expression of NOS1 protein] CTD PMID:23501611 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO
EXP
puerarin results in decreased expression of NOS2 mRNA
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]
CTD PMID:20706672, PMID:23146695, PMID:24975872 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases phosphorylation
increases expression
increases activity
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]; [puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide; fulvestrant inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; fulvestrant inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]; W 7 inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; W 7 inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]
puerarin inhibits the reaction [lead acetate results in decreased expression of NOS3 protein]
puerarin results in increased expression of NOS3 mRNA
puerarin results in increased activity of NOS3 protein
CTD PMID:20706672, PMID:21884717, PMID:23501611 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
EXP puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 protein]
puerarin results in increased expression of NQO1 protein
CTD PMID:24975872 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP
ISO
puerarin inhibits the reaction [cadmium acetate results in increased cleavage of PARP1 protein]
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of PARP1 protein]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of PARP1 protein]
CTD PMID:27318789, PMID:27717697, PMID:31273855 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pgr progesterone receptor decreases expression
increases expression
ISO
EXP
puerarin results in decreased expression of PGR mRNA
puerarin results in increased expression of PGR protein
CTD PMID:17142977, PMID:20706672, PMID:22919047 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO puerarin results in increased expression of PLOD3 mRNA CTD PMID:20706672 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link
G Pml PML nuclear body scaffold multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [puerarin results in decreased expression of PML mRNA alternative form] CTD PMID:20416161 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARA mRNA]; puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARA protein]; puerarin inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA] CTD PMID:23927877, PMID:31273855 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression
EXP
ISO
puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG protein]
puerarin results in decreased expression of PPARG mRNA
CTD PMID:20706672, PMID:23500774 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
increases phosphorylation
ISO PRKCD mutant form inhibits the reaction [puerarin results in increased expression of HMOX1 protein]
puerarin results in increased phosphorylation of PRKCD protein
CTD PMID:20060010 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Ptger1 prostaglandin E receptor 1 decreases expression ISO puerarin results in decreased expression of PTGER1 mRNA CTD PMID:20706672 NCBI chr19:24,799,422...24,803,373
Ensembl chr19:24,800,072...24,803,373
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
EXP
ISO
puerarin results in decreased expression of PTGS2 mRNA
puerarin inhibits the reaction [nickel sulfate results in increased expression of PTGS2 protein]
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]
CTD PMID:22919047, PMID:24975872, PMID:26607348 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions
increases expression
decreases expression
ISO arsenic trioxide promotes the reaction [puerarin results in decreased expression of RARA mRNA alternative form]
puerarin results in increased expression of RARA mRNA
CTD PMID:20416161, PMID:20706672 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
puerarin inhibits the reaction [TNF protein results in increased expression of RELA protein]
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; puerarin inhibits the reaction [nickel sulfate affects the localization of RELA protein]
puerarin inhibits the reaction [Carbon Tetrachloride affects the localization of RELA protein]; puerarin inhibits the reaction [Ethanol results in increased activity of [RELA protein binds to NFKB1 protein]]
CTD PMID:17887948, PMID:21884717, PMID:24975872, PMID:26607348, PMID:27318789 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation
multiple interactions
ISO
EXP
puerarin results in increased phosphorylation of RPS6KB1 protein
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of RPS6KB1 protein]
Sirolimus inhibits the reaction [puerarin results in increased phosphorylation of RPS6KB1 protein]
CTD PMID:27762461, PMID:27796870 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Slc25a4 solute carrier family 25 member 4 multiple interactions EXP puerarin inhibits the reaction [cadmium acetate results in increased expression of SLC25A4 mRNA]; puerarin inhibits the reaction [cadmium acetate results in increased expression of SLC25A4 protein] CTD PMID:27717697 NCBI chr16:49,266,903...49,270,698
Ensembl chr16:49,266,903...49,270,698
JBrowse link
G Slc25a5 solute carrier family 25 member 5 multiple interactions EXP puerarin inhibits the reaction [cadmium acetate results in decreased expression of SLC25A5 mRNA]; puerarin inhibits the reaction [cadmium acetate results in decreased expression of SLC25A5 protein] CTD PMID:27717697 NCBI chr  X:123,404,570...123,407,637
Ensembl chr  X:123,404,518...123,407,645
JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO puerarin results in decreased expression of SOD3 mRNA CTD PMID:20706672 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP puerarin inhibits the reaction [lead nitrate results in increased expression of SQSTM1 protein] CTD PMID:27762461 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO puerarin results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of SREBF1 mRNA] CTD PMID:31273855 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tert telomerase reverse transcriptase decreases expression ISO puerarin results in decreased expression of TERT mRNA CTD PMID:20706672 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of TGFB1 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]
CTD PMID:23146695, PMID:27318789, PMID:31273855 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] CTD PMID:23500774 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO puerarin inhibits the reaction [nickel sulfate results in increased expression of TLR4 protein] CTD PMID:26607348 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO
EXP
puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; puerarin inhibits the reaction [TNF protein results in increased expression of RELA protein]
puerarin inhibits the reaction [nickel sulfate results in increased expression of TNF protein]
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
puerarin results in decreased activity of TNF protein
CTD PMID:21884717, PMID:23146695, PMID:26607348 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 increases expression ISO puerarin results in increased expression of TPT1 mRNA CTD PMID:20706672 NCBI chr15:57,891,680...57,894,504
Ensembl chr15:57,891,680...57,894,504
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO puerarin results in increased expression of TXN mRNA CTD PMID:20706672 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression ISO puerarin results in decreased expression of TYRP1 mRNA CTD PMID:20706672 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases metabolic processing ISO UGT1A1 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases metabolic processing ISO UGT1A3 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases metabolic processing ISO UGT1A6 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases metabolic processing ISO UGT1A8 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases metabolic processing ISO UGT1A9 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression EXP puerarin results in decreased expression of VEGFA mRNA CTD PMID:22919047 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression EXP puerarin results in increased expression of XIAP protein CTD PMID:16041641 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            eukaryotic metabolite 18906
              plant metabolite 17359
                puerarin 107
                  puerarin xyloside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        cyclic ketone 13810
                                          isoflavones 3730
                                            isoflavone 242
                                              puerarin 107
                                                puerarin xyloside 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.