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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:puerarin
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Accession:CHEBI:8633 term browser browse the term
Definition:A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 7 and 4' and a beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage.
Synonyms:exact_synonym: (1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-8-yl]-D-glucitol
 related_synonym: Formula=C21H20O9;   InChI=1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1;   InChIKey=HKEAFJYKMMKDOR-VPRICQMDSA-N;   SMILES=OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)ccc2c1occ(-c1ccc(O)cc1)c2=O
 xref: CAS:3681-99-0;   KEGG:C10524;   KNApSAcK:C00006094
 xref_mesh: MESH:C033607
 xref: PMID:25310912;   PMID:25553536;   Reaxys:64198


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puerarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACA mRNA] CTD PMID:31273855 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acacb acetyl-CoA carboxylase beta multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACB mRNA] CTD PMID:31273855 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO puerarin results in increased expression of ACADM mRNA CTD PMID:31273855 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO puerarin inhibits the reaction [lead acetate results in decreased expression of ACHE protein] CTD PMID:23501611 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acly ATP citrate lyase increases expression ISO puerarin results in increased expression of ACLY mRNA CTD PMID:20706672 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO puerarin results in increased expression of ACOX1 mRNA CTD PMID:31273855 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACTA2 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:27318789 PMID:31273855 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO puerarin results in increased phosphorylation of AKT1 protein
fulvestrant inhibits the reaction [puerarin results in increased phosphorylation of AKT1 protein]
CTD PMID:21884717 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin multiple interactions EXP
ISO
puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of ALB protein] CTD PMID:23146695 PMID:23500774 PMID:27318789 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO puerarin results in increased expression of AQP1 mRNA CTD PMID:20706672 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression ISO puerarin results in increased expression of AQP3 mRNA CTD PMID:20706672 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Ar androgen receptor decreases expression ISO puerarin results in decreased expression of AR mRNA CTD PMID:20706672 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
puerarin results in increased expression of BAX protein
puerarin inhibits the reaction [cadmium acetate results in increased expression of BAX mRNA]; puerarin inhibits the reaction [cadmium acetate results in increased expression of BAX protein]
CTD PMID:16055262 PMID:27717697 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
puerarin results in decreased expression of BCL2 mRNA; puerarin results in decreased expression of BCL2 protein
puerarin inhibits the reaction [[Ethanol co-treated with Carbon Tetrachloride] results in increased expression of BCL2 mRNA]; puerarin inhibits the reaction [cadmium acetate results in decreased expression of BCL2 mRNA]; puerarin inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]
arsenic trioxide promotes the reaction [puerarin results in decreased expression of BCL2 mRNA]
CTD PMID:16055262 PMID:16426832 PMID:20416161 PMID:27717697 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [puerarin results in decreased expression of BIRC5 mRNA] CTD PMID:20416161 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
ISO
EXP
arsenic trioxide promotes the reaction [puerarin results in increased expression of CASP3 protein]
puerarin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]
puerarin results in increased activity of CASP3 protein
puerarin inhibits the reaction [cadmium acetate results in increased activity of CASP3 protein]; puerarin inhibits the reaction [lead nitrate results in increased activity of CASP3 protein]; puerarin results in decreased expression of and results in decreased activity of CASP3 protein
CTD PMID:16041641 PMID:16055262 PMID:20416161 PMID:24505050 PMID:27318789 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases expression
multiple interactions
ISO puerarin results in increased expression of CASP8 protein
arsenic trioxide promotes the reaction [puerarin results in increased expression of CASP8 protein]
CTD PMID:20416161 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase multiple interactions EXP puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT protein]; puerarin inhibits the reaction [lead nitrate results in decreased activity of CAT protein] CTD PMID:23315276 PMID:24975872 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of CCN2 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCN2 mRNA] CTD PMID:27318789 PMID:31273855 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Cdh1 cadherin 1 increases expression ISO puerarin results in increased expression of CDH1 mRNA CTD PMID:20706672 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of COL1A1 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] CTD PMID:27318789 PMID:31273855 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein] CTD PMID:23500774 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO puerarin results in increased expression of CPT1A mRNA CTD PMID:31273855 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO puerarin inhibits the reaction [nickel sulfate results in increased phosphorylation of CREB1 protein] CTD PMID:26607348 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cygb cytoglobin decreases expression ISO puerarin results in decreased expression of CYGB mRNA CTD PMID:20706672 NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
ISO puerarin inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline]
puerarin results in increased expression of CYP2E1 protein
CTD PMID:18038910 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP puerarin affects the reaction [Lead affects the expression of CYP7A1] CTD PMID:22001170 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Dsg3 desmoglein 3 decreases expression ISO puerarin results in decreased expression of DSG3 mRNA CTD PMID:20706672 NCBI chr18:11,798,905...11,833,415
Ensembl chr18:11,798,900...11,830,818
JBrowse link
G Egf epidermal growth factor decreases expression ISO puerarin results in decreased expression of EGF mRNA CTD PMID:20706672 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases phosphorylation
EXP puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of EIF4EBP1 protein]
puerarin results in decreased phosphorylation of EIF4EBP1 protein
CTD PMID:27762461 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP puerarin results in decreased expression of ESR1 mRNA CTD PMID:22919047 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 decreases activity
decreases expression
ISO
EXP
puerarin results in decreased activity of ESR2 protein
puerarin results in decreased expression of ESR2 mRNA
CTD PMID:18937077 PMID:20706672 PMID:22919047 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO arsenic trioxide promotes the reaction [puerarin results in increased expression of FASLG protein] CTD PMID:20416161 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of FASN mRNA] CTD PMID:31273855 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO puerarin results in decreased expression of FBN1 mRNA CTD PMID:20706672 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fbn2 fibrillin 2 decreases expression ISO puerarin results in decreased expression of FBN2 mRNA CTD PMID:20706672 NCBI chr18:51,499,737...51,703,976
Ensembl chr18:51,499,737...51,703,976
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO puerarin results in increased expression of FGF1 mRNA CTD PMID:20706672 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO puerarin results in increased expression of FOS mRNA CTD PMID:17142977 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO
EXP
[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in decreased phosphorylation of FYN protein
[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in decreased phosphorylation of FYN protein; FYN protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased activity of NFE2L2 protein]; Lithium Chloride inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in decreased phosphorylation of FYN protein]
CTD PMID:32763437 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO
EXP
[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA; [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein] CTD PMID:32763437 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [puerarin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein]]; puerarin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein] CTD PMID:27796870 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions
increases expression
ISO Sirolimus inhibits the reaction [puerarin results in increased expression of GPER1 protein] CTD PMID:27796870 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
JBrowse link
G Gpi glucose-6-phosphate isomerase multiple interactions EXP puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of GPI mRNA] CTD PMID:33404196 NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO puerarin inhibits the reaction [nickel sulfate results in increased activity of GPT protein] CTD PMID:26607348 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP
ISO
[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased phosphorylation of GSK3B protein CTD PMID:32763437 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions
ISO
EXP
puerarin results in increased expression of GSR protein
puerarin inhibits the reaction [Lead results in decreased activity of GSR protein]
CTD PMID:18038910 PMID:22001170 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Has1 hyaluronan synthase 1 decreases expression ISO puerarin results in decreased expression of HAS1 mRNA CTD PMID:20706672 NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397
JBrowse link
G Hk1 hexokinase 1 multiple interactions EXP puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of HK1 mRNA] CTD PMID:33404196 NCBI chr20:30,230,488...30,332,161
Ensembl chr20:30,230,486...30,332,131
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP puerarin affects the reaction [Lead affects the expression of HMGCR] CTD PMID:22001170 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
bisindolylmaleimide I inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; Cycloheximide inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; PRKCD mutant form inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [puerarin results in increased expression of HMOX1 protein]
puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 protein]
puerarin results in increased expression of HMOX1 mRNA; puerarin results in increased expression of HMOX1 protein
CTD PMID:20060010 PMID:24975872 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO puerarin results in increased expression of HSPB1 mRNA CTD PMID:20706672 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:21884717 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IFNG mRNA] CTD PMID:31273855 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression
multiple interactions
ISO puerarin results in decreased expression of IGF1 mRNA
puerarin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]
CTD PMID:20706672 PMID:23927877 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO puerarin results in decreased expression of IL1A mRNA CTD PMID:20706672 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IL1B mRNA] CTD PMID:31273855 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IL6 mRNA]; puerarin inhibits the reaction [nickel sulfate results in increased expression of IL6 protein] CTD PMID:26607348 PMID:31273855 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Insr insulin receptor multiple interactions ISO puerarin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA] CTD PMID:23927877 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Kl Klotho decreases expression ISO puerarin results in decreased expression of KL mRNA CTD PMID:20706672 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of LDHA protein] CTD PMID:33404196 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP puerarin affects the reaction [Lead affects the expression of LDLR] CTD PMID:22001170 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lif LIF, interleukin 6 family cytokine decreases expression EXP puerarin results in decreased expression of LIF mRNA CTD PMID:22919047 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
puerarin results in increased phosphorylation of MAPK1 protein
puerarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein]
CTD PMID:21884717 PMID:24975872 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
puerarin results in increased phosphorylation of MAPK3 protein
puerarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK3 protein]
CTD PMID:21884717 PMID:24975872 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
increases expression
ISO arsenic trioxide promotes the reaction [puerarin results in increased expression of MAPK8 protein]
puerarin results in increased phosphorylation of MAPK8 protein
CTD PMID:20416161 PMID:21884717 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO puerarin results in increased phosphorylation of MAPK9 protein CTD PMID:21884717 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mc1r melanocortin 1 receptor decreases expression ISO puerarin results in decreased expression of MC1R mRNA CTD PMID:20706672 NCBI chr19:51,452,448...51,455,375 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP2 mRNA] CTD PMID:23500774 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression
multiple interactions
ISO
EXP
puerarin results in increased expression of COX1 mRNA
puerarin inhibits the reaction [lead nitrate results in decreased expression of COX1 mRNA]
CTD PMID:20706672 PMID:23315276 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions EXP puerarin inhibits the reaction [lead nitrate results in decreased expression of COX2 mRNA] CTD PMID:23315276 Ensembl chr MT:7,006...7,689 JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III multiple interactions EXP puerarin inhibits the reaction [lead nitrate results in decreased expression of COX3 mRNA] CTD PMID:23315276 Ensembl chr MT:8,599...9,382 JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases phosphorylation
ISO
EXP
Sirolimus inhibits the reaction [puerarin results in increased phosphorylation of MTOR protein]
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of MTOR protein]
CTD PMID:27762461 PMID:27796870 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO puerarin results in decreased expression of MYC protein CTD PMID:16055262 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects localization
EXP
ISO
[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased activity of and affects the localization of NFE2L2 protein; FYN protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased activity of NFE2L2 protein]; Lithium Chloride inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased activity of NFE2L2 protein]; puerarin inhibits the reaction [Carbon Tetrachloride affects the localization of NFE2L2 protein]
[1-Methyl-4-phenylpyridinium co-treated with puerarin] affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein]
puerarin affects the localization of NFE2L2 protein
CTD PMID:24975872 PMID:32763437 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP puerarin inhibits the reaction [Ethanol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to NFKB1 protein]]]; puerarin inhibits the reaction [Ethanol results in decreased activity of [NFKB1 protein binds to NFKB1 protein]]; puerarin inhibits the reaction [Ethanol results in increased activity of [RELA protein binds to NFKB1 protein]] CTD PMID:17887948 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO puerarin inhibits the reaction [Carbon Tetrachloride results in increased degradation of NFKBIA protein] CTD PMID:27318789 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO puerarin inhibits the reaction [lead acetate results in decreased expression of NOS1 protein] CTD PMID:23501611 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO
EXP
puerarin results in decreased expression of NOS2 mRNA
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]
CTD PMID:20706672 PMID:23146695 PMID:24975872 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases phosphorylation
increases expression
increases activity
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]; [puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide; fulvestrant inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; fulvestrant inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]; W 7 inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; W 7 inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]
puerarin inhibits the reaction [lead acetate results in decreased expression of NOS3 protein]
puerarin results in increased expression of NOS3 mRNA
puerarin results in increased activity of NOS3 protein
CTD PMID:20706672 PMID:21884717 PMID:23501611 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
EXP puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 protein]
puerarin results in increased expression of NQO1 protein
CTD PMID:24975872 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP
ISO
puerarin inhibits the reaction [cadmium acetate results in increased cleavage of PARP1 protein]
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of PARP1 protein]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of PARP1 protein]
CTD PMID:27318789 PMID:27717697 PMID:31273855 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pfkp phosphofructokinase, platelet multiple interactions EXP puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of PFKP mRNA] CTD PMID:33404196 NCBI chr17:63,729,743...63,794,021
Ensembl chr17:63,729,780...63,794,018
JBrowse link
G Pgam1 phosphoglycerate mutase 1 multiple interactions EXP puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of PGAM1 mRNA] CTD PMID:33404196 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452
JBrowse link
G Pgr progesterone receptor decreases expression
increases expression
ISO
EXP
puerarin results in decreased expression of PGR mRNA
puerarin results in increased expression of PGR protein
CTD PMID:17142977 PMID:20706672 PMID:22919047 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO puerarin results in increased expression of PLOD3 mRNA CTD PMID:20706672 NCBI chr12:19,676,384...19,686,945
Ensembl chr12:19,676,386...19,686,960
JBrowse link
G Pml PML nuclear body scaffold multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [puerarin results in decreased expression of PML mRNA alternative form] CTD PMID:20416161 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARA mRNA]; puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARA protein]; puerarin inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA] CTD PMID:23927877 PMID:31273855 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression
EXP
ISO
puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG protein]
puerarin results in decreased expression of PPARG mRNA
CTD PMID:20706672 PMID:23500774 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of PPARGC1A protein] CTD PMID:33404196 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
increases phosphorylation
ISO PRKCD mutant form inhibits the reaction [puerarin results in increased expression of HMOX1 protein]
puerarin results in increased phosphorylation of PRKCD protein
CTD PMID:20060010 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Ptger1 prostaglandin E receptor 1 decreases expression ISO puerarin results in decreased expression of PTGER1 mRNA CTD PMID:20706672 NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
EXP
ISO
puerarin results in decreased expression of PTGS2 mRNA
puerarin inhibits the reaction [nickel sulfate results in increased expression of PTGS2 protein]
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]
CTD PMID:22919047 PMID:24975872 PMID:26607348 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions
increases expression
decreases expression
ISO arsenic trioxide promotes the reaction [puerarin results in decreased expression of RARA mRNA alternative form]
puerarin results in increased expression of RARA mRNA
CTD PMID:20416161 PMID:20706672 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
puerarin inhibits the reaction [TNF protein results in increased expression of RELA protein]
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; puerarin inhibits the reaction [nickel sulfate affects the localization of RELA protein]
puerarin inhibits the reaction [Carbon Tetrachloride affects the localization of RELA protein]; puerarin inhibits the reaction [Ethanol results in increased activity of [RELA protein binds to NFKB1 protein]]
CTD PMID:17887948 PMID:21884717 PMID:24975872 PMID:26607348 PMID:27318789 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation
multiple interactions
ISO
EXP
puerarin results in increased phosphorylation of RPS6KB1 protein
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of RPS6KB1 protein]
Sirolimus inhibits the reaction [puerarin results in increased phosphorylation of RPS6KB1 protein]
CTD PMID:27762461 PMID:27796870 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of SIRT1 protein] CTD PMID:33404196 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc25a4 solute carrier family 25 member 4 multiple interactions EXP puerarin inhibits the reaction [cadmium acetate results in increased expression of SLC25A4 mRNA]; puerarin inhibits the reaction [cadmium acetate results in increased expression of SLC25A4 protein] CTD PMID:27717697 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
JBrowse link
G Slc25a5 solute carrier family 25 member 5 multiple interactions EXP puerarin inhibits the reaction [cadmium acetate results in decreased expression of SLC25A5 mRNA]; puerarin inhibits the reaction [cadmium acetate results in decreased expression of SLC25A5 protein] CTD PMID:27717697 NCBI chr  X:116,031,896...116,034,963
Ensembl chr  X:116,031,803...116,034,967
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions EXP puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of SLC2A1 protein] CTD PMID:33404196 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO puerarin results in decreased expression of SOD3 mRNA CTD PMID:20706672 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP puerarin inhibits the reaction [lead nitrate results in increased expression of SQSTM1 protein] CTD PMID:27762461 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO puerarin results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of SREBF1 mRNA] CTD PMID:31273855 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tert telomerase reverse transcriptase decreases expression ISO puerarin results in decreased expression of TERT mRNA CTD PMID:20706672 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of TGFB1 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]
CTD PMID:23146695 PMID:27318789 PMID:31273855 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] CTD PMID:23500774 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO puerarin inhibits the reaction [nickel sulfate results in increased expression of TLR4 protein] CTD PMID:26607348 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO
EXP
puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; puerarin inhibits the reaction [TNF protein results in increased expression of RELA protein]
puerarin inhibits the reaction [nickel sulfate results in increased expression of TNF protein]
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
puerarin results in decreased activity of TNF protein
CTD PMID:21884717 PMID:23146695 PMID:26607348 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 increases expression ISO puerarin results in increased expression of TPT1 mRNA CTD PMID:20706672 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO puerarin results in increased expression of TXN mRNA CTD PMID:20706672 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression ISO puerarin results in decreased expression of TYRP1 mRNA CTD PMID:20706672 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in increased expression of UCP2 protein] CTD PMID:33404196 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases metabolic processing ISO UGT1A1 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases metabolic processing ISO UGT1A3 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases metabolic processing ISO UGT1A6 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases metabolic processing ISO UGT1A9 protein results in increased metabolism of puerarin CTD PMID:22648071 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression EXP puerarin results in decreased expression of VEGFA mRNA CTD PMID:22919047 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression EXP puerarin results in increased expression of XIAP protein CTD PMID:16041641 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            eukaryotic metabolite 19044
              plant metabolite 17455
                puerarin 118
                  puerarin xyloside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      ketone 16924
                                        cyclic ketone 15393
                                          isoflavones 3758
                                            isoflavone 253
                                              puerarin 118
                                                puerarin xyloside 0
paths to the root