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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
puerarin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin] |
CTD |
PMID:34217736 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Acaca |
acetyl-CoA carboxylase alpha |
multiple interactions |
ISO |
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACA mRNA] |
CTD |
PMID:31273855 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Acacb |
acetyl-CoA carboxylase beta |
multiple interactions |
ISO |
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACB mRNA] |
CTD |
PMID:31273855 |
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NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
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G |
Acadm |
acyl-CoA dehydrogenase medium chain |
increases expression |
ISO |
puerarin results in increased expression of ACADM mRNA |
CTD |
PMID:31273855 |
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NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
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G |
Ache |
acetylcholinesterase |
multiple interactions |
ISO |
puerarin inhibits the reaction [lead acetate results in decreased expression of ACHE protein] |
CTD |
PMID:23501611 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Acly |
ATP citrate lyase |
increases expression |
ISO |
puerarin results in increased expression of ACLY mRNA |
CTD |
PMID:20706672 |
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NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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G |
Acox1 |
acyl-CoA oxidase 1 |
increases expression |
ISO |
puerarin results in increased expression of ACOX1 mRNA |
CTD |
PMID:31273855 |
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NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACTA2 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] |
CTD |
PMID:27318789 PMID:31273855 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation multiple interactions |
ISO |
puerarin results in increased phosphorylation of AKT1 protein fulvestrant inhibits the reaction [puerarin results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:21884717 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alb |
albumin |
multiple interactions |
EXP ISO |
puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of ALB protein] |
CTD |
PMID:23146695 PMID:23500774 PMID:27318789 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Aqp1 |
aquaporin 1 |
increases expression |
ISO |
puerarin results in increased expression of AQP1 mRNA |
CTD |
PMID:20706672 |
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NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
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G |
Aqp3 |
aquaporin 3 (Gill blood group) |
increases expression |
ISO |
puerarin results in increased expression of AQP3 mRNA |
CTD |
PMID:20706672 |
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NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
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G |
Ar |
androgen receptor |
decreases expression |
ISO |
puerarin results in decreased expression of AR mRNA |
CTD |
PMID:20706672 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO EXP |
puerarin results in increased expression of BAX protein puerarin inhibits the reaction [cadmium acetate results in increased expression of BAX mRNA]; puerarin inhibits the reaction [cadmium acetate results in increased expression of BAX protein] |
CTD |
PMID:16055262 PMID:27717697 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
puerarin results in decreased expression of BCL2 mRNA; puerarin results in decreased expression of BCL2 protein Arsenic Trioxide promotes the reaction [puerarin results in decreased expression of BCL2 mRNA]; puerarin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein] puerarin inhibits the reaction [[Ethanol co-treated with Carbon Tetrachloride] results in increased expression of BCL2 mRNA]; puerarin inhibits the reaction [cadmium acetate results in decreased expression of BCL2 mRNA]; puerarin inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein] |
CTD |
PMID:16055262 PMID:16426832 PMID:20416161 PMID:27717697 PMID:35331853 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions decreases expression |
ISO |
arsenic trioxide promotes the reaction [puerarin results in decreased expression of BIRC5 mRNA] |
CTD |
PMID:20416161 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp1 |
caspase 1 |
multiple interactions |
ISO |
puerarin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP1 protein] |
CTD |
PMID:35331853 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity increases expression |
ISO EXP |
arsenic trioxide promotes the reaction [puerarin results in increased expression of CASP3 protein] puerarin inhibits the reaction [cadmium acetate results in increased activity of CASP3 protein]; puerarin inhibits the reaction [lead nitrate results in increased activity of CASP3 protein]; puerarin results in decreased expression of and results in decreased activity of CASP3 protein puerarin results in increased activity of CASP3 protein puerarin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein] |
CTD |
PMID:16041641 PMID:16055262 PMID:20416161 PMID:24505050 PMID:27318789 PMID:27717697 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases expression multiple interactions |
ISO |
puerarin results in increased expression of CASP8 protein arsenic trioxide promotes the reaction [puerarin results in increased expression of CASP8 protein] |
CTD |
PMID:20416161 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Cat |
catalase |
multiple interactions |
EXP |
puerarin inhibits the reaction [cadmium acetate results in increased activity of CAT protein]; puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT protein]; puerarin inhibits the reaction [lead nitrate results in decreased activity of CAT protein] |
CTD |
PMID:23315276 PMID:24975872 PMID:34897960 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccn2 |
cellular communication network factor 2 |
multiple interactions |
ISO |
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of CCN2 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCN2 mRNA] |
CTD |
PMID:27318789 PMID:31273855 |
|
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Cdh1 |
cadherin 1 |
increases expression |
ISO |
puerarin results in increased expression of CDH1 mRNA |
CTD |
PMID:20706672 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of COL1A1 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] |
CTD |
PMID:27318789 PMID:31273855 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
EXP |
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein] |
CTD |
PMID:23500774 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression |
ISO |
puerarin results in increased expression of CPT1A mRNA |
CTD |
PMID:31273855 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
puerarin inhibits the reaction [nickel sulfate results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:26607348 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Ctsk |
cathepsin K |
multiple interactions |
EXP |
puerarin inhibits the reaction [cadmium acetate results in decreased expression of CTSK protein]; puerarin inhibits the reaction [cadmium acetate results in increased expression of CTSK mRNA] |
CTD |
PMID:34897960 |
|
NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
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G |
Cygb |
cytoglobin |
decreases expression |
ISO |
puerarin results in decreased expression of CYGB mRNA |
CTD |
PMID:20706672 |
|
NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions increases expression |
ISO |
puerarin inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline] puerarin results in increased expression of CYP2E1 protein |
CTD |
PMID:18038910 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
multiple interactions |
EXP |
puerarin affects the reaction [Lead affects the expression of CYP7A1] |
CTD |
PMID:22001170 |
|
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Dsg3 |
desmoglein 3 |
decreases expression |
ISO |
puerarin results in decreased expression of DSG3 mRNA |
CTD |
PMID:20706672 |
|
NCBI chr18:11,799,355...11,830,988
Ensembl chr18:11,798,900...11,830,818
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G |
Egf |
epidermal growth factor |
decreases expression |
ISO |
puerarin results in decreased expression of EGF mRNA |
CTD |
PMID:20706672 |
|
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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|
G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
multiple interactions decreases phosphorylation |
EXP |
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of EIF4EBP1 protein] puerarin results in decreased phosphorylation of EIF4EBP1 protein |
CTD |
PMID:27762461 |
|
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Esr1 |
estrogen receptor 1 |
decreases expression |
EXP |
puerarin results in decreased expression of ESR1 mRNA |
CTD |
PMID:22919047 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
decreases activity decreases expression |
ISO EXP |
puerarin results in decreased activity of ESR2 protein puerarin results in decreased expression of ESR2 mRNA |
CTD |
PMID:18937077 PMID:20706672 PMID:22919047 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Faslg |
Fas ligand |
multiple interactions increases expression |
ISO |
arsenic trioxide promotes the reaction [puerarin results in increased expression of FASLG protein] |
CTD |
PMID:20416161 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of FASN mRNA] |
CTD |
PMID:31273855 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fbn1 |
fibrillin 1 |
decreases expression |
ISO |
puerarin results in decreased expression of FBN1 mRNA |
CTD |
PMID:20706672 |
|
NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
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G |
Fbn2 |
fibrillin 2 |
decreases expression |
ISO |
puerarin results in decreased expression of FBN2 mRNA |
CTD |
PMID:20706672 |
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NCBI chr18:51,499,670...51,703,976
Ensembl chr18:51,499,737...51,703,976
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G |
Fgf1 |
fibroblast growth factor 1 |
increases expression |
ISO |
puerarin results in increased expression of FGF1 mRNA |
CTD |
PMID:20706672 |
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NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
puerarin results in increased expression of FOS mRNA |
CTD |
PMID:17142977 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fyn |
FYN proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO EXP |
[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in decreased phosphorylation of FYN protein [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in decreased phosphorylation of FYN protein; FYN protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased activity of NFE2L2 protein]; Lithium Chloride inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in decreased phosphorylation of FYN protein] |
CTD |
PMID:32763437 |
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NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO EXP |
[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA; [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein] |
CTD |
PMID:32763437 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gdnf |
glial cell derived neurotrophic factor |
multiple interactions |
ISO |
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [puerarin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein]]; puerarin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein] |
CTD |
PMID:27796870 |
|
NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
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G |
Gper1 |
G protein-coupled estrogen receptor 1 |
multiple interactions increases expression |
ISO |
Sirolimus inhibits the reaction [puerarin results in increased expression of GPER1 protein] |
CTD |
PMID:27796870 |
|
NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
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G |
Gpi |
glucose-6-phosphate isomerase |
multiple interactions |
EXP |
puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of GPI mRNA] |
CTD |
PMID:33404196 |
|
NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
puerarin inhibits the reaction [nickel sulfate results in increased activity of GPT protein] |
CTD |
PMID:26607348 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
EXP ISO |
[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased phosphorylation of GSK3B protein |
CTD |
PMID:32763437 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsr |
glutathione-disulfide reductase |
increases expression multiple interactions |
ISO EXP |
puerarin results in increased expression of GSR protein puerarin inhibits the reaction [Lead results in decreased activity of GSR protein] |
CTD |
PMID:18038910 PMID:22001170 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Has1 |
hyaluronan synthase 1 |
decreases expression |
ISO |
puerarin results in decreased expression of HAS1 mRNA |
CTD |
PMID:20706672 |
|
NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397
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G |
Hk1 |
hexokinase 1 |
multiple interactions |
EXP |
puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of HK1 mRNA] |
CTD |
PMID:33404196 |
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NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
EXP |
puerarin affects the reaction [Lead affects the expression of HMGCR] |
CTD |
PMID:22001170 |
|
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO EXP |
bisindolylmaleimide I inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; Cycloheximide inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; PRKCD mutant form inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [puerarin results in increased expression of HMOX1 protein] puerarin results in increased expression of HMOX1 mRNA; puerarin results in increased expression of HMOX1 protein puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 protein] |
CTD |
PMID:20060010 PMID:24975872 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
increases expression |
ISO |
puerarin results in increased expression of HSPB1 mRNA |
CTD |
PMID:20706672 |
|
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
CTD |
PMID:21884717 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IFNG mRNA] |
CTD |
PMID:31273855 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Igf1 |
insulin-like growth factor 1 |
decreases expression multiple interactions |
ISO |
puerarin results in decreased expression of IGF1 mRNA puerarin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein] |
CTD |
PMID:20706672 PMID:23927877 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Il18 |
interleukin 18 |
multiple interactions |
ISO |
PRKAA1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]; puerarin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL18 protein]; SIRT1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]] |
CTD |
PMID:35331853 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1a |
interleukin 1 alpha |
decreases expression |
ISO |
puerarin results in decreased expression of IL1A mRNA |
CTD |
PMID:20706672 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IL1B mRNA] PRKAA1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; puerarin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; SIRT1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]] |
CTD |
PMID:31273855 PMID:35331853 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IL6 mRNA]; puerarin inhibits the reaction [nickel sulfate results in increased expression of IL6 protein] |
CTD |
PMID:26607348 PMID:31273855 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Insr |
insulin receptor |
multiple interactions |
ISO |
puerarin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA] |
CTD |
PMID:23927877 |
|
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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G |
Kl |
Klotho |
decreases expression |
ISO |
puerarin results in decreased expression of KL mRNA |
CTD |
PMID:20706672 |
|
NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
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G |
Lamtor1 |
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 |
multiple interactions |
EXP |
puerarin promotes the reaction [cadmium acetate results in decreased expression of LAMTOR1 protein] |
CTD |
PMID:34897960 |
|
NCBI chr 1:156,272,116...156,277,687
Ensembl chr 1:156,272,064...156,291,179
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G |
Ldha |
lactate dehydrogenase A |
multiple interactions |
EXP |
puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of LDHA protein] |
CTD |
PMID:33404196 |
|
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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|
G |
Ldlr |
low density lipoprotein receptor |
multiple interactions |
EXP |
puerarin affects the reaction [Lead affects the expression of LDLR] |
CTD |
PMID:22001170 |
|
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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|
G |
Lif |
LIF, interleukin 6 family cytokine |
decreases expression |
EXP |
puerarin results in decreased expression of LIF mRNA |
CTD |
PMID:22919047 |
|
NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
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|
G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
EXP |
puerarin inhibits the reaction [cadmium acetate results in decreased expression of MAP1LC3B protein modified form] |
CTD |
PMID:34897960 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO EXP |
puerarin results in increased phosphorylation of MAPK1 protein puerarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:21884717 PMID:24975872 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO EXP |
puerarin results in increased phosphorylation of MAPK3 protein puerarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:21884717 PMID:24975872 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases expression increases phosphorylation |
ISO |
arsenic trioxide promotes the reaction [puerarin results in increased expression of MAPK8 protein] puerarin results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:20416161 PMID:21884717 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases phosphorylation |
ISO |
puerarin results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:21884717 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mc1r |
melanocortin 1 receptor |
decreases expression |
ISO |
puerarin results in decreased expression of MC1R mRNA |
CTD |
PMID:20706672 |
|
NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
EXP |
puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP2 mRNA] |
CTD |
PMID:23500774 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mt-co1 |
mitochondrially encoded cytochrome c oxidase I |
increases expression multiple interactions |
ISO EXP |
puerarin results in increased expression of COX1 mRNA puerarin inhibits the reaction [lead nitrate results in decreased expression of COX1 mRNA] |
CTD |
PMID:20706672 PMID:23315276 |
|
NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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|
G |
Mt-co2 |
mitochondrially encoded cytochrome c oxidase II |
multiple interactions |
EXP |
puerarin inhibits the reaction [lead nitrate results in decreased expression of COX2 mRNA] |
CTD |
PMID:23315276 |
|
NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
|
|
G |
Mt-co3 |
mitochondrially encoded cytochrome c oxidase III |
multiple interactions |
EXP |
puerarin inhibits the reaction [lead nitrate results in decreased expression of COX3 mRNA] |
CTD |
PMID:23315276 |
|
NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions increases phosphorylation |
ISO EXP |
Sirolimus inhibits the reaction [puerarin results in increased phosphorylation of MTOR protein] puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of MTOR protein] |
CTD |
PMID:27762461 PMID:27796870 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression |
ISO |
puerarin results in decreased expression of MYC protein |
CTD |
PMID:16055262 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions affects localization |
EXP ISO |
[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased activity of and affects the localization of NFE2L2 protein; FYN protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased activity of NFE2L2 protein]; Lithium Chloride inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased activity of NFE2L2 protein]; puerarin inhibits the reaction [Carbon Tetrachloride affects the localization of NFE2L2 protein] puerarin affects the localization of NFE2L2 protein [1-Methyl-4-phenylpyridinium co-treated with puerarin] affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein] |
CTD |
PMID:24975872 PMID:32763437 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
EXP |
puerarin inhibits the reaction [Ethanol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to NFKB1 protein]]]; puerarin inhibits the reaction [Ethanol results in decreased activity of [NFKB1 protein binds to NFKB1 protein]]; puerarin inhibits the reaction [Ethanol results in increased activity of [RELA protein binds to NFKB1 protein]] |
CTD |
PMID:17887948 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
puerarin inhibits the reaction [Carbon Tetrachloride results in increased degradation of NFKBIA protein] |
CTD |
PMID:27318789 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
puerarin inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] |
CTD |
PMID:35331853 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nos1 |
nitric oxide synthase 1 |
multiple interactions |
ISO |
puerarin inhibits the reaction [lead acetate results in decreased expression of NOS1 protein] |
CTD |
PMID:23501611 |
|
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nos2 |
nitric oxide synthase 2 |
decreases expression multiple interactions |
ISO EXP |
puerarin results in decreased expression of NOS2 mRNA puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein] |
CTD |
PMID:20706672 PMID:23146695 PMID:24975872 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions increases activity increases expression increases phosphorylation |
ISO |
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]; [puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide; fulvestrant inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; fulvestrant inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]; W 7 inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; W 7 inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein] puerarin results in increased activity of NOS3 protein puerarin results in increased expression of NOS3 mRNA puerarin inhibits the reaction [lead acetate results in decreased expression of NOS3 protein] |
CTD |
PMID:20706672 PMID:21884717 PMID:23501611 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases expression |
EXP |
puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 protein] puerarin results in increased expression of NQO1 protein |
CTD |
PMID:24975872 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
EXP ISO |
puerarin inhibits the reaction [cadmium acetate results in increased cleavage of PARP1 protein] puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of PARP1 protein]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of PARP1 protein] |
CTD |
PMID:27318789 PMID:27717697 PMID:31273855 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pfkp |
phosphofructokinase, platelet |
multiple interactions |
EXP |
puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of PFKP mRNA] |
CTD |
PMID:33404196 |
|
NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018
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G |
Pgam1 |
phosphoglycerate mutase 1 |
multiple interactions |
EXP |
puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of PGAM1 mRNA] |
CTD |
PMID:33404196 |
|
NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452
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G |
Pgr |
progesterone receptor |
decreases expression increases expression |
ISO EXP |
puerarin results in decreased expression of PGR mRNA puerarin results in increased expression of PGR protein |
CTD |
PMID:17142977 PMID:20706672 PMID:22919047 |
|
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G |
Plod3 |
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 |
increases expression |
ISO |
puerarin results in increased expression of PLOD3 mRNA |
CTD |
PMID:20706672 |
|
NCBI chr12:19,676,384...19,686,945
Ensembl chr12:19,676,386...19,686,960
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G |
Pml |
PML nuclear body scaffold |
multiple interactions decreases expression |
ISO |
arsenic trioxide promotes the reaction [puerarin results in decreased expression of PML mRNA alternative form] |
CTD |
PMID:20416161 |
|
NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARA mRNA]; puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARA protein]; puerarin inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA] |
CTD |
PMID:23927877 PMID:31273855 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions decreases expression |
EXP ISO |
puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG protein] puerarin results in decreased expression of PPARG mRNA |
CTD |
PMID:20706672 PMID:23500774 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
EXP |
puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of PPARGC1A protein] |
CTD |
PMID:33404196 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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|
G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
multiple interactions |
ISO |
PRKAA1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]; PRKAA1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; puerarin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein] |
CTD |
PMID:35331853 |
|
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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G |
Prkcd |
protein kinase C, delta |
multiple interactions increases phosphorylation |
ISO |
PRKCD mutant form inhibits the reaction [puerarin results in increased expression of HMOX1 protein] puerarin results in increased phosphorylation of PRKCD protein |
CTD |
PMID:20060010 |
|
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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G |
Ptger1 |
prostaglandin E receptor 1 |
decreases expression |
ISO |
puerarin results in decreased expression of PTGER1 mRNA |
CTD |
PMID:20706672 |
|
NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression multiple interactions |
EXP ISO |
puerarin results in decreased expression of PTGS2 mRNA puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] puerarin inhibits the reaction [nickel sulfate results in increased expression of PTGS2 protein] |
CTD |
PMID:22919047 PMID:24975872 PMID:26607348 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Pycard |
PYD and CARD domain containing |
multiple interactions |
ISO |
puerarin inhibits the reaction [Lipopolysaccharides results in increased expression of PYCARD protein] |
CTD |
PMID:35331853 |
|
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
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G |
Rara |
retinoic acid receptor, alpha |
multiple interactions decreases expression increases expression |
ISO |
arsenic trioxide promotes the reaction [puerarin results in decreased expression of RARA mRNA alternative form] puerarin results in increased expression of RARA mRNA |
CTD |
PMID:20416161 PMID:20706672 |
|
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
puerarin inhibits the reaction [TNF protein results in increased expression of RELA protein] puerarin inhibits the reaction [Carbon Tetrachloride affects the localization of RELA protein]; puerarin inhibits the reaction [Ethanol results in increased activity of [RELA protein binds to NFKB1 protein]] puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; puerarin inhibits the reaction [nickel sulfate affects the localization of RELA protein] |
CTD |
PMID:17887948 PMID:21884717 PMID:24975872 PMID:26607348 PMID:27318789 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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|
G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
increases phosphorylation multiple interactions |
ISO EXP |
puerarin results in increased phosphorylation of RPS6KB1 protein Sirolimus inhibits the reaction [puerarin results in increased phosphorylation of RPS6KB1 protein] puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of RPS6KB1 protein] |
CTD |
PMID:27762461 PMID:27796870 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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|
G |
Runx2 |
RUNX family transcription factor 2 |
multiple interactions |
EXP |
puerarin inhibits the reaction [cadmium acetate results in decreased expression of RUNX2 protein] |
CTD |
PMID:34897960 |
|
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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|
G |
Sirt1 |
sirtuin 1 |
multiple interactions |
EXP ISO |
puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of SIRT1 protein] puerarin inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]; SIRT1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]; SIRT1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]] |
CTD |
PMID:33404196 PMID:35331853 |
|
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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|
G |
Slc25a4 |
solute carrier family 25 member 4 |
multiple interactions |
EXP |
puerarin inhibits the reaction [cadmium acetate results in increased expression of SLC25A4 mRNA]; puerarin inhibits the reaction [cadmium acetate results in increased expression of SLC25A4 protein] |
CTD |
PMID:27717697 |
|
NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
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|
G |
Slc25a5 |
solute carrier family 25 member 5 |
multiple interactions |
EXP |
puerarin inhibits the reaction [cadmium acetate results in decreased expression of SLC25A5 mRNA]; puerarin inhibits the reaction [cadmium acetate results in decreased expression of SLC25A5 protein] |
CTD |
PMID:27717697 |
|
NCBI chr X:116,031,896...116,034,963
Ensembl chr X:116,031,803...116,034,967
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|
G |
Slc2a1 |
solute carrier family 2 member 1 |
multiple interactions |
EXP |
puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of SLC2A1 protein] |
CTD |
PMID:33404196 |
|
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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|
G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
puerarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of SOD2 protein] |
CTD |
PMID:36527706 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sod3 |
superoxide dismutase 3 |
decreases expression |
ISO |
puerarin results in decreased expression of SOD3 mRNA |
CTD |
PMID:20706672 |
|
NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
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|
G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
EXP |
puerarin inhibits the reaction [lead nitrate results in increased expression of SQSTM1 protein]; puerarin promotes the reaction [cadmium acetate results in increased expression of SQSTM1 protein] |
CTD |
PMID:27762461 PMID:34897960 |
|
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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|
G |
Srd5a2 |
steroid 5 alpha-reductase 2 |
decreases expression |
ISO |
puerarin results in decreased expression of SRD5A2 mRNA |
CTD |
PMID:20706672 |
|
NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112
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|
G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of SREBF1 mRNA] |
CTD |
PMID:31273855 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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|
G |
Tert |
telomerase reverse transcriptase |
decreases expression |
ISO |
puerarin results in decreased expression of TERT mRNA |
CTD |
PMID:20706672 |
|
NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
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|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP ISO |
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] puerarin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of TGFB1 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] |
CTD |
PMID:23146695 PMID:27318789 PMID:31273855 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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|
G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
EXP |
puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] |
CTD |
PMID:23500774 |
|
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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|
G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
puerarin inhibits the reaction [nickel sulfate results in increased expression of TLR4 protein] |
CTD |
PMID:26607348 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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|
G |
Tnf |
tumor necrosis factor |
multiple interactions decreases activity |
ISO EXP |
puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; puerarin inhibits the reaction [TNF protein results in increased expression of RELA protein] puerarin results in decreased activity of TNF protein puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] puerarin inhibits the reaction [nickel sulfate results in increased expression of TNF protein] |
CTD |
PMID:21884717 PMID:23146695 PMID:26607348 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf11b |
TNF receptor superfamily member 11B |
multiple interactions |
EXP |
puerarin promotes the reaction [cadmium acetate results in increased expression of TNFRSF11B mRNA] |
CTD |
PMID:34897960 |
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NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
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G |
Tnfsf11 |
TNF superfamily member 11 |
multiple interactions |
EXP |
[cadmium acetate co-treated with puerarin] results in increased expression of TNFSF11 mRNA |
CTD |
PMID:34897960 |
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NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
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G |
Tpt1 |
tumor protein, translationally-controlled 1 |
increases expression |
ISO |
puerarin results in increased expression of TPT1 mRNA |
CTD |
PMID:20706672 |
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NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
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G |
Txn1 |
thioredoxin 1 |
increases expression |
ISO |
puerarin results in increased expression of TXN mRNA |
CTD |
PMID:20706672 |
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NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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G |
Tyrp1 |
tyrosinase-related protein 1 |
decreases expression |
ISO |
puerarin results in decreased expression of TYRP1 mRNA |
CTD |
PMID:20706672 |
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NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
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G |
Ucp2 |
uncoupling protein 2 |
multiple interactions |
EXP |
puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in increased expression of UCP2 protein] |
CTD |
PMID:33404196 |
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NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases metabolic processing |
ISO |
UGT1A1 protein results in increased metabolism of puerarin |
CTD |
PMID:22648071 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases metabolic processing |
ISO |
UGT1A3 protein results in increased metabolism of puerarin |
CTD |
PMID:22648071 |
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NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
increases metabolic processing |
ISO |
UGT1A6 protein results in increased metabolism of puerarin |
CTD |
PMID:22648071 |
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NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases metabolic processing |
ISO |
UGT1A9 protein results in increased metabolism of puerarin |
CTD |
PMID:22648071 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
EXP |
puerarin results in decreased expression of VEGFA mRNA |
CTD |
PMID:22919047 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Xiap |
X-linked inhibitor of apoptosis |
increases expression |
EXP |
puerarin results in increased expression of XIAP protein |
CTD |
PMID:16041641 |
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NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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