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G |
Ctbp2 |
C-terminal binding protein 2 |
decreases expression |
ISO |
2-keto-4-methylthiobutyric acid results in decreased expression of CTBP2 protein |
CTD |
PMID:28414304 |
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NCBI chr 1:205,001,354...205,030,565
Ensembl chr 1:205,001,396...205,040,755
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G |
Ctnnb1 |
catenin beta 1 |
decreases expression |
ISO |
2-keto-4-methylthiobutyric acid results in decreased expression of CTNNB1 protein |
CTD |
PMID:28414304 |
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NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
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G |
Kyat1 |
kynurenine aminotransferase 1 |
affects metabolic processing |
EXP |
KYAT1 protein affects the metabolism of 2-keto-4-methylthiobutyric acid |
CTD |
PMID:2711386 |
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NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
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G |
Odc1 |
ornithine decarboxylase 1 |
decreases activity |
ISO |
2-keto-4-methylthiobutyric acid results in decreased activity of ODC1 protein |
CTD |
PMID:16870157 |
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NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
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G |
Ache |
acetylcholinesterase |
decreases activity |
EXP ISO |
Aldicarb results in decreased activity of ACHE protein |
CTD |
PMID:8134223 PMID:14644616 PMID:16256972 PMID:21251949 PMID:23962483 PMID:27132127 |
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NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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G |
Chrna4 |
cholinergic receptor nicotinic alpha 4 subunit |
multiple interactions |
EXP |
Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] |
CTD |
PMID:14644616 |
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NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
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G |
Chrnb4 |
cholinergic receptor nicotinic beta 4 subunit |
multiple interactions |
EXP |
Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] |
CTD |
PMID:14644616 |
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NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
Aldicarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein] |
CTD |
PMID:9126867 |
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NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G |
Il2 |
interleukin 2 |
decreases response to substance |
ISO |
Aldicarb results in decreased susceptibility to IL2 protein |
CTD |
PMID:8349949 |
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NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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G |
Nefh |
neurofilament heavy |
increases phosphorylation |
ISO |
Aldicarb results in increased phosphorylation of NEFH protein |
CTD |
PMID:16256972 |
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NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
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G |
Nrxn1 |
neurexin 1 |
multiple interactions |
ISO |
NRXN1 protein affects the reaction [NLG-1 results in increased susceptibility to Aldicarb]; NRXN1 protein affects the reaction [NRX-1 results in decreased susceptibility to Aldicarb] |
CTD |
PMID:23638761 |
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NCBI chr 6:13,886,757...15,191,660
Ensembl chr 6:13,886,740...15,191,660
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G |
Pgr |
progesterone receptor |
multiple interactions |
ISO |
Aldicarb inhibits the reaction [Progesterone results in increased activity of PGR protein] |
CTD |
PMID:9126867 |
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NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
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G |
Pon1 |
paraoxonase 1 |
multiple interactions |
ISO EXP |
[Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to Aldicarb; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Aldicarb |
CTD |
PMID:27132127 |
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NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
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G |
Vpreb1 |
V-set pre-B cell surrogate light chain 1 |
decreases expression |
ISO |
Aldicarb results in decreased expression of VPREB1 mRNA |
CTD |
PMID:25424538 |
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NCBI chr11:88,376,256...88,377,133
Ensembl chr11:88,376,256...88,377,133
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G |
Cdh1 |
cadherin 1 |
decreases expression |
EXP |
ametryne results in decreased expression of CDH1 mRNA |
CTD |
PMID:26310382 |
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NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
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G |
Cdh2 |
cadherin 2 |
increases expression |
EXP |
ametryne results in increased expression of CDH2 mRNA |
CTD |
PMID:26310382 |
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NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions increases metabolic processing |
ISO |
POR protein promotes the reaction [CYP1A2 protein results in increased metabolism of ametryne] |
CTD |
PMID:8971136 |
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NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G |
Gja1 |
gap junction protein, alpha 1 |
decreases expression |
EXP |
ametryne results in decreased expression of GJA1 mRNA |
CTD |
PMID:26310382 |
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NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
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G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
EXP |
ametryne results in increased expression of GSTM1 mRNA |
CTD |
PMID:26310382 |
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NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
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G |
Por |
cytochrome p450 oxidoreductase |
multiple interactions |
ISO |
POR protein promotes the reaction [CYP1A2 protein results in increased metabolism of ametryne] |
CTD |
PMID:8971136 |
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NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
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G |
Sod2 |
superoxide dismutase 2 |
increases expression |
EXP |
ametryne results in increased expression of SOD2 mRNA |
CTD |
PMID:26310382 |
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NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Ache |
acetylcholinesterase |
multiple interactions decreases activity |
ISO EXP |
methamidophos promotes the reaction [Methomyl results in decreased activity of ACHE protein]; Methomyl promotes the reaction [methamidophos results in decreased activity of ACHE protein] |
CTD |
PMID:8134223 PMID:19371631 PMID:19934164 PMID:21251949 PMID:23962483 PMID:25707986 |
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NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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G |
Bche |
butyrylcholinesterase |
multiple interactions |
EXP |
[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein |
CTD |
PMID:22649187 |
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NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
increases activity |
ISO |
Methomyl results in increased activity of CYP19A1 protein |
CTD |
PMID:11884232 |
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NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
Methomyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] |
CTD |
PMID:9126867 |
|
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G |
Fshb |
follicle stimulating hormone subunit beta |
increases expression |
EXP |
Methomyl results in increased expression of FSHB protein |
CTD |
PMID:11516254 |
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NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
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G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
decreases expression |
ISO |
Methomyl results in decreased expression of HSP90B1 protein |
CTD |
PMID:16271832 |
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NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
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G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
decreases expression |
ISO |
Methomyl results in decreased expression of HSPA1A protein |
CTD |
PMID:16271832 |
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NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
Methomyl results in increased expression of HSPA5 protein |
CTD |
PMID:16271832 |
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NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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G |
Hspa8 |
heat shock protein family A (Hsp70) member 8 |
decreases expression |
ISO |
Methomyl results in decreased expression of HSPA8 protein |
CTD |
PMID:16271832 |
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NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
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G |
Kyat1 |
kynurenine aminotransferase 1 |
decreases activity |
ISO |
Methomyl results in decreased activity of KYAT1 protein |
CTD |
PMID:7175100 |
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NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
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G |
Kynu |
kynureninase |
decreases activity |
ISO |
Methomyl results in decreased activity of KYNU protein |
CTD |
PMID:7175100 |
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NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
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G |
Lhb |
luteinizing hormone subunit beta |
increases expression |
EXP |
Methomyl results in increased expression of LHB protein |
CTD |
PMID:11516254 |
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NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
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G |
Pgr |
progesterone receptor |
multiple interactions |
ISO |
Methomyl inhibits the reaction [Progesterone results in increased activity of PGR protein] |
CTD |
PMID:9126867 |
|
NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
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G |
Prl |
prolactin |
increases expression |
EXP |
Methomyl results in increased expression of PRL protein |
CTD |
PMID:11516254 |
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NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions |
ISO |
neticonazole affects the localization of and results in increased activity of NR1I3 protein |
CTD |
PMID:30247703 |
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NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of BAX protein] Pergolide inhibits the reaction [Levodopa results in increased expression of BAX protein] |
CTD |
PMID:15081873 PMID:15672541 |
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NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of CDKN1A protein] |
CTD |
PMID:15081873 |
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NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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G |
Drd1 |
dopamine receptor D1 |
increases activity |
ISO |
Pergolide results in increased activity of DRD1 protein |
CTD |
PMID:16129789 |
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NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
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G |
Drd2 |
dopamine receptor D2 |
increases activity |
ISO |
Pergolide results in increased activity of DRD2 protein |
CTD |
PMID:16129789 |
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NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
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G |
Gdnf |
glial cell derived neurotrophic factor |
increases expression increases secretion |
ISO |
Pergolide results in increased expression of GDNF mRNA Pergolide results in increased secretion of GDNF protein |
CTD |
PMID:12770616 |
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NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
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G |
Kcna5 |
potassium voltage-gated channel subfamily A member 5 |
decreases activity |
ISO |
Pergolide results in decreased activity of KCNA5 protein |
CTD |
PMID:16129789 |
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NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
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G |
Kcnma1 |
potassium calcium-activated channel subfamily M alpha 1 |
decreases activity |
EXP |
Pergolide results in decreased activity of KCNMA1 protein |
CTD |
PMID:16129789 |
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NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956
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G |
Msh2 |
mutS homolog 2 |
multiple interactions |
ISO |
Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein] |
CTD |
PMID:15081873 |
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NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
Pergolide inhibits the reaction [Hydrogen Peroxide affects the localization of NFKB1 protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of NFKB1 protein] |
CTD |
PMID:15081873 |
|
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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G |
Ngf |
nerve growth factor |
increases expression increases secretion |
ISO |
Pergolide results in increased expression of NGF mRNA Pergolide results in increased secretion of NGF protein |
CTD |
PMID:12770616 |
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NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Pergolide inhibits the reaction [Hydrogen Peroxide affects the localization of RELA protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of RELA protein] |
CTD |
PMID:15081873 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Pergolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
|
NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of BAX protein]; Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of CDKN1A protein]; Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein] Pergolide inhibits the reaction [Levodopa results in increased expression of TRP53 protein] |
CTD |
PMID:15081873 PMID:15672541 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
Prometryne binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:21115097 |
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NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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G |
Adh5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
multiple interactions |
ISO |
S-methyl glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] |
CTD |
PMID:19428350 |
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NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
S-methyl glutathione inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein] |
CTD |
PMID:26124276 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases metabolic processing multiple interactions |
ISO |
CYP1A2 protein results in increased metabolism of terbutryne POR protein promotes the reaction [CYP1A2 protein results in increased metabolism of terbutryne] |
CTD |
PMID:8971136 |
|
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
terbutryne binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:20024649 |
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NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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G |
Por |
cytochrome p450 oxidoreductase |
multiple interactions |
ISO |
POR protein promotes the reaction [CYP1A2 protein results in increased metabolism of terbutryne] |
CTD |
PMID:8971136 |
|
NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
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G |
Ache |
acetylcholinesterase |
decreases activity |
ISO EXP |
thiodicarb results in decreased activity of ACHE protein |
CTD |
PMID:21251949 |
|
NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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