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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methyl sulfide
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Accession:CHEBI:86315 term browser browse the term
Definition:Any aliphatic sulfide in which at least one of the organyl groups attached to the sulfur is a methyl group.
Synonyms:related_synonym: Formula=CH3SR;   SMILES=CS[*];   a methyl thioether;   methyl sulfides;   methyl thioether;   methyl thioethers
 alt_id: CHEBI:25260
 xref: MetaCyc:Methyl-thioethers


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4-methylthio-2-oxobutanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctbp2 C-terminal binding protein 2 decreases expression ISO 2-keto-4-methylthiobutyric acid results in decreased expression of CTBP2 protein CTD PMID:28414304 NCBI chr 1:187,782,064...187,918,115
Ensembl chr 1:187,782,682...187,920,222 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO 2-keto-4-methylthiobutyric acid results in decreased expression of CTNNB1 protein CTD PMID:28414304 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Kyat1 kynurenine aminotransferase 1 affects metabolic processing EXP KYAT1 protein affects the metabolism of 2-keto-4-methylthiobutyric acid CTD PMID:2711386 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355 		JBrowse link
G Odc1 ornithine decarboxylase 1 decreases activity ISO 2-keto-4-methylthiobutyric acid results in decreased activity of ODC1 protein CTD PMID:16870157 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
aldicarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP
ISO		 Aldicarb results in decreased activity of ACHE protein CTD PMID:8134223 PMID:14644616 PMID:16256972 PMID:21251949 PMID:23962483 More... NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G App amyloid beta precursor protein decreases response to substance ISO APP protein modified form results in decreased susceptibility to Aldicarb CTD PMID:34902447 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Aldicarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Aldicarb results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO Aldicarb promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA] CTD PMID:32949729 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Nefh neurofilament heavy chain increases phosphorylation ISO Aldicarb results in increased phosphorylation of NEFH protein CTD PMID:16256972 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nrxn1 neurexin 1 multiple interactions ISO NRXN1 protein affects the reaction [NLG-1 results in increased susceptibility to Aldicarb]; NRXN1 protein affects the reaction [NRX-1 results in decreased susceptibility to Aldicarb] CTD PMID:23638761 NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710 		JBrowse link
G Pax6 paired box 6 multiple interactions ISO Aldicarb inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA] CTD PMID:32949729 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Aldicarb inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO
EXP		 [Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to Aldicarb; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Aldicarb CTD PMID:27132127 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Vpreb1a V-set pre-B cell surrogate light chain 1A decreases expression ISO Aldicarb results in decreased expression of VPREB1 mRNA CTD PMID:25424538 NCBI chr11:84,126,969...84,127,846
Ensembl chr11:84,126,969...84,127,846 		JBrowse link
ametryn term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh1 cadherin 1 decreases expression EXP ametryne results in decreased expression of CDH1 mRNA CTD PMID:26310382 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 increases expression EXP ametryne results in increased expression of CDH2 mRNA CTD PMID:26310382 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing		 ISO POR protein promotes the reaction [CYP1A2 protein results in increased metabolism of ametryne] CTD PMID:8971136 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression EXP ametryne results in decreased expression of GJA1 mRNA CTD PMID:26310382 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP ametryne results in increased expression of GSTM1 mRNA CTD PMID:26310382 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO POR protein promotes the reaction [CYP1A2 protein results in increased metabolism of ametryne] CTD PMID:8971136 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP ametryne results in increased expression of SOD2 mRNA CTD PMID:26310382 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
methiocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP Methiocarb results in decreased activity of ACHE protein CTD PMID:19934164 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acvr2b activin A receptor type 2B decreases expression EXP Methiocarb results in decreased expression of SCGB2A2 mRNA CTD PMID:15519604 NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458 		JBrowse link
G Alb albumin increases hydrolysis
multiple interactions		 ISO
EXP		 ALB protein results in increased hydrolysis of Methiocarb
bis(4-nitrophenyl)phosphate inhibits the reaction [ALB protein results in increased hydrolysis of Methiocarb]		 CTD PMID:27665777 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Ar androgen receptor multiple interactions ISO
EXP		 Dihydrotestosterone inhibits the reaction [Methiocarb results in increased activity of AR protein]; Methiocarb inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Methiocarb inhibits the reaction [Metribolone results in increased activity of AR protein]
Methiocarb inhibits the reaction [Metribolone results in increased expression of AR mRNA]		 CTD PMID:15064155 PMID:15519604 PMID:18324785 PMID:21310686 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases metabolic processing		 ISO [CYP2B6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases metabolic processing
multiple interactions		 ISO CYP2C19 protein results in increased metabolism of Methiocarb
[CYP2C19 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide		 CTD PMID:27665777 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions		 ISO CYP2D6 protein results in increased metabolism of Methiocarb
[CYP2D6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide		 CTD PMID:27665777 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Esr1 estrogen receptor 1 increases activity
increases expression		 ISO Methiocarb results in increased activity of ESR1 protein
Methiocarb results in increased expression of ESR1 protein		 CTD PMID:15064155 PMID:19206145 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases activity
increases expression		 ISO Methiocarb results in increased activity of ESR2 protein
Methiocarb results in increased expression of ESR2 mRNA		 CTD PMID:15064155 PMID:15130599 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 multiple interactions
increases metabolic processing		 ISO [FMO1 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Methiocarb results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Methiocarb results in decreased expression of LHB protein CTD PMID:15519604 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity EXP Methiocarb results in increased activity of NR1I2 protein CTD PMID:27665777 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression EXP Methiocarb results in decreased expression of ODC1 mRNA CTD PMID:15519604 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity EXP Methiocarb results in increased activity of PPARA protein CTD PMID:27665777 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Methiocarb binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
methomyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity		 ISO
EXP		 methamidophos promotes the reaction [Methomyl results in decreased activity of ACHE protein]; Methomyl promotes the reaction [methamidophos results in decreased activity of ACHE protein] CTD PMID:8134223 PMID:19371631 PMID:19934164 PMID:21251949 PMID:23962483 More... NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Methomyl results in increased expression of BAX mRNA CTD PMID:34676817 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Methomyl results in decreased expression of BCL2 mRNA CTD PMID:34676817 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases expression ISO Methomyl results in increased expression of CASP3 mRNA CTD PMID:34676817 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO Methomyl results in increased activity of CYP19A1 protein CTD PMID:11884232 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Methomyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP Methomyl results in increased expression of FSHB protein CTD PMID:11516254 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression ISO Methomyl results in decreased expression of HSP90B1 protein CTD PMID:16271832 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO Methomyl results in decreased expression of HSPA1A protein CTD PMID:16271832 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Methomyl results in increased expression of HSPA5 protein CTD PMID:16271832 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO Methomyl results in decreased expression of HSPA8 protein CTD PMID:16271832 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity ISO Methomyl results in decreased activity of KYAT1 protein CTD PMID:7175100 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355 		JBrowse link
G Kynu kynureninase decreases activity ISO Methomyl results in decreased activity of KYNU protein CTD PMID:7175100 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Methomyl results in increased expression of LHB protein CTD PMID:11516254 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Methomyl inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Prl prolactin increases expression EXP Methomyl results in increased expression of PRL protein CTD PMID:11516254 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G S100a1 S100 calcium binding protein A1 multiple interactions EXP Methomyl results in increased expression of and affects the localization of S100A1 protein CTD PMID:30472887 NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 increases expression EXP Methomyl results in increased expression of TPT1 protein CTD PMID:30472887 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625 		JBrowse link
N-acetyl-L-methionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glud1 glutamate dehydrogenase 1 decreases activity EXP N-acetylmethionine results in decreased activity of GLUD1 protein CTD PMID:37871522 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957 		JBrowse link
neticonazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO neticonazole affects the localization of and results in increased activity of NR1I3 protein CTD PMID:30247703 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
pergolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of BAX protein]
Pergolide inhibits the reaction [Levodopa results in increased expression of BAX protein]		 CTD PMID:15081873 PMID:15672541 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of CDKN1A protein] CTD PMID:15081873 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Drd1 dopamine receptor D1 increases activity ISO Pergolide results in increased activity of DRD1 protein CTD PMID:16129789 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 increases activity ISO Pergolide results in increased activity of DRD2 protein CTD PMID:16129789 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression
increases secretion		 ISO Pergolide results in increased expression of GDNF mRNA
Pergolide results in increased secretion of GDNF protein		 CTD PMID:12770616 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 decreases activity ISO Pergolide results in decreased activity of KCNA5 protein CTD PMID:16129789 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697 		JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 decreases activity EXP Pergolide results in decreased activity of KCNMA1 protein CTD PMID:16129789 NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198 		JBrowse link
G Msh2 mutS homolog 2 multiple interactions ISO Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein] CTD PMID:15081873 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Pergolide inhibits the reaction [Hydrogen Peroxide affects the localization of NFKB1 protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of NFKB1 protein] CTD PMID:15081873 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Ngf nerve growth factor increases expression
increases secretion		 ISO Pergolide results in increased expression of NGF mRNA
Pergolide results in increased secretion of NGF protein		 CTD PMID:12770616 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Pergolide inhibits the reaction [Hydrogen Peroxide affects the localization of RELA protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of RELA protein] CTD PMID:15081873 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Pergolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of BAX protein]; Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of CDKN1A protein]; Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]
Pergolide inhibits the reaction [Levodopa results in increased expression of TRP53 protein]		 CTD PMID:15081873 PMID:15672541 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
prometryn term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Prometryne binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
S-methylglutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions ISO S-methyl glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] CTD PMID:19428350 NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO S-methyl glutathione inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein] CTD PMID:26124276 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
saroglitazar term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO saroglitazar inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA] CTD PMID:32613381 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein] CTD PMID:32613381 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA] CTD PMID:32613381 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA] CTD PMID:32613381 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 multiple interactions ISO saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA] CTD PMID:32613381 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA]; saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein] CTD PMID:32613381 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA]; saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein] CTD PMID:32613381 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA] CTD PMID:32613381 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO saroglitazar inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA] CTD PMID:32613381 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA]; saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein] CTD PMID:32613381 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
terbutryn term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions		 ISO CYP1A2 protein results in increased metabolism of terbutryne
POR protein promotes the reaction [CYP1A2 protein results in increased metabolism of terbutryne]		 CTD PMID:8971136 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO terbutryne binds to and results in increased activity of NR1I2 protein CTD PMID:20024649 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO POR protein promotes the reaction [CYP1A2 protein results in increased metabolism of terbutryne] CTD PMID:8971136 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
thiodicarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP		 thiodicarb results in decreased activity of ACHE protein CTD PMID:21251949 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    chemical entity 19915
      atom 19915
        nonmetal atom 19838
          sulfur atom 17778
            sulfur molecular entity 17778
              organosulfur compound 17473
                organic sulfide 10113
                  methyl sulfide 75
                    (methylsulfanyl)acetaldehyde + 0
                    (methylsulfanyl)acetaldehyde oxime 0
                    (methylthio)acetic acid + 0
                    1,2-dihydroxy-5-(methylthio)pent-1-en-3-one 0
                    1-(methylsulfanyl)acetaldoxime + 19
                    1-(methylthio)ribulose 5-phosphate 0
                    1-aci-nitro-omega-(methylsulfanyl)alkane + 0
                    1-isothiocyanato-6-(methylsulfanyl)hexane 0
                    2-(omega-methylthio)alkylmaleic acid + 0
                    2-(omega-methylthio)alkylmalic acid + 0
                    2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate 0
                    2-methyl-2-(methylsulfanyl)propanal oxime + 13
                    2-methyl-5-(methylthio)furan 0
                    2-methylthio-1,3-benzothiazole 0
                    3-(methylsulfanyl)propanal oxime 0
                    3-(omega-methylthio)alkylmalic acid + 0
                    3-methylthioaspartic acid + 0
                    3-methylthiopropanol + 0
                    3-methylthiopropyl acetate 0
                    4-(methylsulfanyl)butanal oxime 0
                    4-Methylthiobutylthiohydroximate 0
                    5-(methylsulfanyl)pentanal oxime + 0
                    6-(methylthio)hexanonitrile oxide 0
                    7-(methylthio)heptanonitrile oxide 0
                    8-(methylthio)octylisothiocyanate 0
                    9-[(methylthio)nonyl]thiohydroximic acid 0
                    L-beta-homomethionine 0
                    L-polyhomomethionine + 0
                    MK-8353 0
                    MXNB 0
                    MXNH 0
                    MXNP 0
                    N,N-dihydroxy-L-polyhomomethionine + 0
                    N-\{[2-(3-chloro-4-fluorophenyl)hydrazino]carbonyl\}-3,5-bis(methylthio)isothiazole-4-carboxamide 0
                    N-acetyl-S-methyl-L-cysteine 0
                    N-acetylmethionine + 1
                    N-hydroxy-L-polyhomomethionine + 0
                    PD173955 + 0
                    S-[9-(methylthio)nonylhydroximoyl]-L-cysteine 0
                    S-methyl-5-thio-D-ribofuranose + 0
                    S-methyl-L-ergothioneine 0
                    S-methylglutathione 2
                    butyl 2-(methylsulfanyl)acetate 0
                    butyl 3-(methylsulfanyl)propanoate 0
                    ethyl 3-(methylthio)propionate 0
                    gamma-thiomethyl glutamate 0
                    hexahomomethionine + 0
                    mannostatin A 0
                    maremycin G 0
                    methiocarb 17
                    methylthio-1,3,5-triazine + 8
                    neticonazole 1
                    omega-(methylsulfanyl)-(E)-alkanal oxime + 0
                    omega-(methylthio)-2-oxocarboxylic acid + 4
                    pergolide 13
                    saroglitazar 10
                    tetrahomomethionine + 0
                    trihomomethionine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            heteroorganic entity 19549
                              organochalcogen compound 19309
                                organosulfur compound 17473
                                  organic sulfide 10113
                                    methyl sulfide 75
                                      (methylsulfanyl)acetaldehyde + 0
                                      (methylsulfanyl)acetaldehyde oxime 0
                                      (methylthio)acetic acid + 0
                                      1,2-dihydroxy-5-(methylthio)pent-1-en-3-one 0
                                      1-(methylsulfanyl)acetaldoxime + 19
                                      1-(methylthio)ribulose 5-phosphate 0
                                      1-aci-nitro-omega-(methylsulfanyl)alkane + 0
                                      1-isothiocyanato-6-(methylsulfanyl)hexane 0
                                      2-(omega-methylthio)alkylmaleic acid + 0
                                      2-(omega-methylthio)alkylmalic acid + 0
                                      2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate 0
                                      2-methyl-2-(methylsulfanyl)propanal oxime + 13
                                      2-methyl-5-(methylthio)furan 0
                                      2-methylthio-1,3-benzothiazole 0
                                      3-(methylsulfanyl)propanal oxime 0
                                      3-(omega-methylthio)alkylmalic acid + 0
                                      3-methylthioaspartic acid + 0
                                      3-methylthiopropanol + 0
                                      3-methylthiopropyl acetate 0
                                      4-(methylsulfanyl)butanal oxime 0
                                      4-Methylthiobutylthiohydroximate 0
                                      5-(methylsulfanyl)pentanal oxime + 0
                                      6-(methylthio)hexanonitrile oxide 0
                                      7-(methylthio)heptanonitrile oxide 0
                                      8-(methylthio)octylisothiocyanate 0
                                      9-[(methylthio)nonyl]thiohydroximic acid 0
                                      L-beta-homomethionine 0
                                      L-polyhomomethionine + 0
                                      MK-8353 0
                                      MXNB 0
                                      MXNH 0
                                      MXNP 0
                                      N,N-dihydroxy-L-polyhomomethionine + 0
                                      N-\{[2-(3-chloro-4-fluorophenyl)hydrazino]carbonyl\}-3,5-bis(methylthio)isothiazole-4-carboxamide 0
                                      N-acetyl-S-methyl-L-cysteine 0
                                      N-acetylmethionine + 1
                                      N-hydroxy-L-polyhomomethionine + 0
                                      PD173955 + 0
                                      S-[9-(methylthio)nonylhydroximoyl]-L-cysteine 0
                                      S-methyl-5-thio-D-ribofuranose + 0
                                      S-methyl-L-ergothioneine 0
                                      S-methylglutathione 2
                                      butyl 2-(methylsulfanyl)acetate 0
                                      butyl 3-(methylsulfanyl)propanoate 0
                                      ethyl 3-(methylthio)propionate 0
                                      gamma-thiomethyl glutamate 0
                                      hexahomomethionine + 0
                                      mannostatin A 0
                                      maremycin G 0
                                      methiocarb 17
                                      methylthio-1,3,5-triazine + 8
                                      neticonazole 1
                                      omega-(methylsulfanyl)-(E)-alkanal oxime + 0
                                      omega-(methylthio)-2-oxocarboxylic acid + 4
                                      pergolide 13
                                      saroglitazar 10
                                      tetrahomomethionine + 0
                                      trihomomethionine + 0
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