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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:psoralidin
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Accession:CHEBI:8616 term browser browse the term
Definition:A member of the class of coumestans that is coumestan substituted by hydroxy groups at positions 3 and 9 and a prenyl group at position 2 respectively.
Synonyms:exact_synonym: 3,9-dihydroxy-2-(3-methylbut-2-en-1-yl)-6H-[1]benzofuro[3,2-c][1]benzopyran-6-one
 related_synonym: 3,9-Dihydroxy-2-prenylcoumestan;   Formula=C20H16O5;   InChI=1S/C20H16O5/c1-10(2)3-4-11-7-14-17(9-15(11)22)25-20(23)18-13-6-5-12(21)8-16(13)24-19(14)18/h3,5-9,21-22H,4H2,1-2H3;   InChIKey=YABIJLLNNFURIJ-UHFFFAOYSA-N;   SMILES=CC(C)=CCc1cc2c3oc4cc(O)ccc4c3c(=O)oc2cc1O
 xref: CAS:18642-23-4;   HMDB:HMDB0034050;   KEGG:C10523;   KNApSAcK:C00002566;   LIPID_MAPS_instance:LMPK12090007
 xref_mesh: MESH:C102768
 xref: PMID:24507928;   PMID:25216634;   Reaxys:320069;   Wikipedia:Psoralidin



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psoralidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions
EXP psoralidin results in decreased activity of CYP2E1 protein
psoralidin inhibits the reaction [[CYP2E1 protein results in increased metabolism of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]
CTD PMID:31870919 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP psoralidin results in increased expression of CYP3A4 mRNA CTD PMID:31870919 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        pharmacological role 18974
          agonist 18506
            estrogen receptor agonist 1196
              psoralidin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      carboxylic ester 15962
                                        lactone 11411
                                          delta-lactone 3897
                                            coumestan 1786
                                              psoralidin 2
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