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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:psoralidin
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Accession:CHEBI:8616 term browser browse the term
Definition:A member of the class of coumestans that is coumestan substituted by hydroxy groups at positions 3 and 9 and a prenyl group at position 2 respectively.
Synonyms:exact_synonym: 3,9-dihydroxy-2-(3-methylbut-2-en-1-yl)-6H-[1]benzofuro[3,2-c][1]benzopyran-6-one
 related_synonym: 3,9-Dihydroxy-2-prenylcoumestan;   Formula=C20H16O5;   InChI=1S/C20H16O5/c1-10(2)3-4-11-7-14-17(9-15(11)22)25-20(23)18-13-6-5-12(21)8-16(13)24-19(14)18/h3,5-9,21-22H,4H2,1-2H3;   InChIKey=YABIJLLNNFURIJ-UHFFFAOYSA-N;   SMILES=CC(C)=CCc1cc2c3oc4cc(O)ccc4c3c(=O)oc2cc1O
 xref: CAS:18642-23-4;   HMDB:HMDB0034050;   KEGG:C10523;   KNApSAcK:C00002566;   LIPID_MAPS_instance:LMPK12090007
 xref_mesh: MESH:C102768
 xref: PMID:24507928;   PMID:25216634;   Reaxys:320069;   Wikipedia:Psoralidin


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psoralidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions
EXP psoralidin results in decreased activity of CYP2E1 protein
psoralidin inhibits the reaction [[CYP2E1 protein results in increased metabolism of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]
CTD PMID:31870919 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression EXP psoralidin results in increased expression of CYP3A4 mRNA CTD PMID:31870919 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        pharmacological role 18825
          agonist 18251
            estrogen receptor agonist 1176
              psoralidin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic ester 15500
                                        lactone 9716
                                          delta-lactone 3829
                                            coumestan 1778
                                              psoralidin 2
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