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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lenvatinib mesylate
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Accession:CHEBI:85995 term browser browse the term
Definition:A methanesulfonate salt obtained by reaction of lenvatinib with one molar equivalent of methanesulfonic acid. A multi-kinase inhibitor and orphan drug used (as its mesylate salt) for the treatment of various types of thyroid cancer that do not respond to radioiodine.
Synonyms:exact_synonym: 6-carbamoyl-4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinolin-1-ium methanesulfonate;   methanesulfonic acid--4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide (1/1)
 related_synonym: E7080;   Formula=C22H23ClN4O7S;   InChI=1S/C21H19ClN4O4.CH4O3S/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11;1-5(2,3)4/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28);1H3,(H,2,3,4);   InChIKey=HWLFIUUAYLEFCT-UHFFFAOYSA-N;   Lenvatinib mesilate;   Lenvima;   N-(4-((6-Carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)-N'-cyclopropylurea monomethanesulfonate;   SMILES=C=1(C(=CC2=C(C1)N=CC=C2OC3=CC(=C(C=C3)NC(NC4CC4)=O)Cl)C(N)=O)OC.S(=O)(=O)(C)O;   UNII-3J78384F61
 xref: CAS:857890-39-2;   KEGG:D09920;   PMID:24190702;   PMID:24548978;   PMID:24658627;   PMID:24815456;   PMID:25022720;   PMID:25295214;   PMID:25425971;   PMID:25795101;   PMID:25798037;   PMID:25798040;   PMID:25859118;   PMID:25913680;   PMID:26026266;   Reaxys:14616854


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Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        pharmaceutical 19304
          drug 19304
            antineoplastic agent 17259
              lenvatinib mesylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      chalcogen 19387
                        oxygen atom 19350
                          oxygen molecular entity 19350
                            hydroxides 19076
                              oxoacid 18275
                                chalcogen oxoacid 11503
                                  sulfur oxoacid 11110
                                    sulfonic acid 7370
                                      sulfo group 5770
                                        organosulfonic acid 5770
                                          alkanesulfonic acid 3981
                                            methanesulfonic acid 3970
                                              methanesulfonates 3967
                                                methanesulfonate salt 1
                                                  lenvatinib mesylate 0
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