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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:85994 term browser browse the term
Definition:A member of the class of quinolines that is the carboxamide of 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxylic acid. A multi-kinase inhibitor and orphan drug used (as its mesylate salt) for the treatment of various types of thyroid cancer that do not respond to radioiodine.
Synonyms:exact_synonym: 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide
 related_synonym: 4-(3-Chloro-4-(N'-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide;   E 7080;   E7080;   Formula=C21H19ClN4O4;   InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28);   InChIKey=WOSKHXYHFSIKNG-UHFFFAOYSA-N;   SMILES=C=1(C(=CC2=C(C1)N=CC=C2OC3=CC(=C(C=C3)NC(NC4CC4)=O)Cl)C(N)=O)OC;   UNII-EE083865G2
 xref: CAS:417716-92-8;   Drug_Central:4942;   KEGG:D09919;   PDBeChem:LEV;   PMID:25240824;   PMID:25458359;   PMID:25589937;   PMID:25600977;   PMID:25616432;   PMID:25625428;   PMID:25671254;   PMID:25720434;   PMID:25795101;   PMID:25859118;   PMID:25913680;   PMID:25974026;   PMID:26008987;   PMID:26026266;   Reaxys:12096874;   Wikipedia:Lenvatinib
 cyclic_relationship: is_conjugate_base_of CHEBI:85998

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  CHEBI ontology 19783
    role 19728
      application 19419
        pharmaceutical 19317
          drug 19317
            antineoplastic agent 17256
              lenvatinib 0
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  CHEBI ontology 19783
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18606
                              organic divalent group 18597
                                organodiyl group 18597
                                  carbonyl group 18510
                                    carbonyl compound 18510
                                      carboxylic acid 18163
                                        carboacyl group 17417
                                          univalent carboacyl group 17417
                                            carbamoyl group 17213
                                              carboxamide 17213
                                                monocarboxylic acid amide 14600
                                                  urea 5022
                                                    ureas 5020
                                                      phenylureas 2017
                                                        lenvatinib 0
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