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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:palbociclib
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Accession:CHEBI:85993 term browser browse the term
Definition:A member of the class of pyridopyrimidines that is 2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7-one bearing additional methyl, acetyl and cyclopentyl substituents at positions 5, 6 and 8 respectively. It is used in combination with letrozole for the treatment of metastatic breast cancer.
Synonyms:exact_synonym: 6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
 related_synonym: 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one;   Formula=C24H29N7O2;   IBRANCE;   InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29);   InChIKey=AHJRHEGDXFFMBM-UHFFFAOYSA-N;   PD 332991;   PD-0332991;   PD0332991;   SMILES=CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O;   UNII-G9ZF61LE7G
 xref: CAS:571190-30-2;   KEGG:D10372
 xref_mesh: MESH:C500026
 xref: PDBeChem:LQQ;   PMID:25417786;   PMID:25494820;   PMID:25501126;   PMID:25522918;   PMID:25524798;   PMID:25744718;   PMID:25792301;   PMID:25813205;   PMID:26030518;   PMID:26036642;   Reaxys:10219048;   Wikipedia:Palbociclib


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palbociclib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO palbociclib results in increased expression of ABCA1 mRNA CTD PMID:22869556 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO BMS 754807 inhibits the reaction [palbociclib results in increased phosphorylation of AKT1 protein]; palbociclib promotes the reaction [idelalisib results in decreased phosphorylation of AKT1 protein] CTD PMID:23676220 PMID:24986516 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Anln anillin, actin binding protein decreases expression ISO palbociclib results in decreased expression of ANLN mRNA CTD PMID:22869556 NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538
JBrowse link
G Apoe apolipoprotein E increases expression ISO palbociclib results in increased expression of APOE mRNA CTD PMID:28620137 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Asf1b anti-silencing function 1B histone chaperone decreases expression ISO palbociclib results in decreased expression of ASF1B mRNA CTD PMID:22869556 NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549
JBrowse link
G Aurka aurora kinase A decreases expression ISO palbociclib results in decreased expression of AURKA mRNA CTD PMID:22869556 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Aurkb aurora kinase B decreases expression ISO palbociclib results in decreased expression of AURKB mRNA CTD PMID:22869556 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Bard1 BRCA1 associated RING domain 1 decreases expression ISO palbociclib results in decreased expression of BARD1 mRNA CTD PMID:22869556 PMID:28620137 NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO palbociclib results in decreased expression of BIRC5 mRNA CTD PMID:22869556 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bora bora, aurora kinase A activator decreases expression ISO palbociclib results in decreased expression of BORA mRNA CTD PMID:22869556 NCBI chr15:75,797,624...75,835,599
Ensembl chr15:75,797,891...75,821,322
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression ISO palbociclib results in decreased expression of BUB1 mRNA CTD PMID:22869556 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases cleavage
ISO [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of CASP3 protein; palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; palbociclib inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; palbociclib inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]
palbociclib results in increased cleavage of CASP3 protein
[CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP3 protein
palbociclib results in decreased cleavage of CASP3 protein
CTD PMID:22302033 PMID:22751436 PMID:23676220 PMID:24098593 PMID:27099147 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Etoposide results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Paclitaxel results in increased activity of CASP7 protein]
[CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP7 protein
CTD PMID:22302033 PMID:24098593 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO palbociclib results in increased expression of CCN1 mRNA CTD PMID:22869556 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccna2 cyclin A2 decreases expression
multiple interactions
ISO palbociclib results in decreased expression of CCNA2 mRNA; palbociclib results in decreased expression of CCNA2 protein
E2F2 protein inhibits the reaction [palbociclib results in decreased expression of CCNA2 protein]; palbociclib inhibits the reaction [Doxorubicin results in increased expression of CCNA2 protein]; palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]; palbociclib promotes the reaction [RB1 protein binds to CCNA2 promoter]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of CCNA2 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]]; RB1 protein affects the reaction [palbociclib results in decreased expression of CCNA2 protein]
CTD PMID:20100483 PMID:20473330 PMID:21367843 PMID:21593195 PMID:22751436 More... NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO palbociclib results in decreased expression of CCNB1 mRNA CTD PMID:22869556 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO palbociclib results in decreased expression of CCNB2 mRNA CTD PMID:22869556 PMID:28620137 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Ccnd1 cyclin D1 decreases response to substance
multiple interactions
increases expression
ISO CCND1 gene results in decreased susceptibility to palbociclib
[CDKN2A gene mutant form results in increased expression of CCND1 protein] which results in increased susceptibility to palbociclib
palbociclib results in increased expression of CCND1 protein
[BMS 754807 co-treated with palbociclib] results in increased expression of CCND1 protein; Doxorubicin inhibits the reaction [palbociclib results in increased expression of CCND1 protein]; palbociclib inhibits the reaction [[CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of SHOX2 protein]; palbociclib promotes the reaction [CCND1 protein binds to CDKN1B protein binds to CDK4 protein]; palbociclib promotes the reaction [CDK4 protein binds to CCND1 protein]
CTD PMID:20473330 PMID:21278246 PMID:22094256 PMID:22751436 PMID:22869556 More... NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 multiple interactions ISO [CDKN2A gene mutant form results in increased expression of CCND2 protein] which results in increased susceptibility to palbociclib CTD PMID:24098593 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression
ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of MEF2D protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein]
[CDKN2A gene mutant form results in increased expression of CCND3 protein] which results in increased susceptibility to palbociclib
palbociclib results in increased expression of CCND3 protein
CTD PMID:20473330 PMID:22094256 PMID:24098593 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 decreases response to substance
decreases expression
increases expression
ISO CCNE1 protein results in decreased susceptibility to palbociclib
palbociclib results in decreased expression of CCNE1 protein
palbociclib results in increased expression of CCNE1 protein
CTD PMID:17537993 PMID:21278246 PMID:21880723 PMID:23708653 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO palbociclib analog results in decreased expression of CCNE2 mRNA; palbociclib results in decreased expression of CCNE2 mRNA CTD PMID:15542782 PMID:22869556 PMID:26318986 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Ccnf cyclin F decreases expression ISO palbociclib results in decreased expression of CCNF mRNA CTD PMID:22869556 PMID:24606660 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
JBrowse link
G Cdc20 cell division cycle 20 decreases expression ISO palbociclib results in decreased expression of CDC20 mRNA CTD PMID:22869556 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO palbociclib results in decreased expression of CDC25A mRNA CTD PMID:22869556 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO palbociclib results in decreased expression of CDC25C mRNA CTD PMID:22869556 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone multiple interactions ISO palbociclib inhibits the reaction [CDC37 protein binds to CDK4 protein]; palbociclib inhibits the reaction [CDC37 protein binds to CDK6 protein] CTD PMID:29091774 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO palbociclib results in decreased expression of CDC45 mRNA CTD PMID:22869556 NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619
JBrowse link
G Cdca3 cell division cycle associated 3 decreases expression ISO palbociclib results in decreased expression of CDCA3 mRNA CTD PMID:22869556 NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799
JBrowse link
G Cdca5 cell division cycle associated 5 decreases expression ISO palbociclib results in decreased expression of CDCA5 mRNA CTD PMID:22869556 NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023
JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression ISO palbociclib results in decreased expression of CDCA8 mRNA CTD PMID:22869556 NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629
JBrowse link
G Cdh1 cadherin 1 affects localization
multiple interactions
ISO palbociclib affects the localization of CDH1 protein
CDH1 protein affects the reaction [palbociclib results in decreased expression of FOXM1 protein]
CTD PMID:22094256 PMID:22869556 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 multiple interactions
increases expression
ISO 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CDH2 protein] CTD PMID:22869556 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO palbociclib analog results in decreased expression of CDK1 mRNA; palbociclib results in decreased expression of CDK1 mRNA CTD PMID:15542782 PMID:22869556 PMID:24606660 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity
multiple interactions
decreases phosphorylation
decreases expression
ISO palbociclib results in decreased activity of CDK2 protein
palbociclib results in increased phosphorylation of and results in increased expression of CDK2 protein
palbociclib results in decreased phosphorylation of CDK2 protein
palbociclib results in decreased expression of CDK2 protein
CTD PMID:17537993 PMID:20100483 PMID:20473330 PMID:21880723 PMID:22869556 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases response to substance
decreases activity
multiple interactions
increases expression
increases response to substance
ISO CDK4 protein results in decreased susceptibility to palbociclib
palbociclib results in decreased activity of CDK4 protein
[CDKN2A gene mutant form results in increased expression of CDK4 protein] which results in increased susceptibility to palbociclib
palbociclib results in increased expression of CDK4 protein
palbociclib inhibits the reaction [[CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of SHOX2 protein]; palbociclib inhibits the reaction [CDC37 protein binds to CDK4 protein]; palbociclib promotes the reaction [CCND1 protein binds to CDKN1B protein binds to CDK4 protein]; palbociclib promotes the reaction [CDK4 protein binds to CCND1 protein]
CDK4 protein results in increased susceptibility to palbociclib
CTD PMID:20473330 PMID:22094256 PMID:22711607 PMID:22761470 PMID:22869556 More... NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
increases expression
ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of MEF2D protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein]; palbociclib inhibits the reaction [CDC37 protein binds to CDK6 protein]
palbociclib results in increased expression of CDK6 protein
[CDKN2A gene mutant form results in increased expression of CDK6 protein] which results in increased susceptibility to palbociclib
CTD PMID:20473330 PMID:22094256 PMID:22869556 PMID:23138228 PMID:24098593 More... NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdk7 cyclin-dependent kinase 7 increases expression ISO palbociclib results in increased expression of CDK7 mRNA CTD PMID:24606660 NCBI chr 2:31,840,545...31,865,447
Ensembl chr 2:31,840,558...31,865,383
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO palbociclib results in increased expression of CDKN1A protein CTD PMID:20473330 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
decreases expression
ISO palbociclib promotes the reaction [CCND1 protein binds to CDKN1B protein binds to CDK4 protein]
palbociclib results in increased expression of CDKN1B mRNA; palbociclib results in increased expression of CDKN1B protein
palbociclib results in decreased expression of CDKN1B protein
CTD PMID:17537993 PMID:20473330 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects response to substance
increases response to substance
multiple interactions
decreases response to substance
ISO CDKN2A gene modified form affects the susceptibility to palbociclib; CDKN2A gene mutant form affects the susceptibility to palbociclib; CDKN2A protein affects the susceptibility to palbociclib
CDKN2A gene mutant form results in increased susceptibility to palbociclib
[CDKN2A gene mutant form results in increased expression of CCND1 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CCND2 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CCND3 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CDK4 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased expression of CDK6 protein] which results in increased susceptibility to palbociclib; [CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP3 protein; [CDKN2A gene mutant form results in increased susceptibility to palbociclib] which affects the activity of CASP7 protein; [CDKN2A gene mutant form results in increased susceptibility to palbociclib] which results in decreased phosphorylation of RB1 protein
CDKN2A protein results in decreased susceptibility to palbociclib
[CDKN2A protein co-treated with CDKN2C protein] affects the susceptibility to palbociclib
CTD PMID:20534551 PMID:21278246 PMID:22711607 PMID:24098593 PMID:24495407 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression
multiple interactions
decreases response to substance
ISO palbociclib results in increased expression of CDKN2B protein
2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CDKN2B protein]
CDKN2B protein results in decreased susceptibility to palbociclib
CTD PMID:22711607 PMID:22869556 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C multiple interactions ISO [CDKN2A protein co-treated with CDKN2C protein] affects the susceptibility to palbociclib CTD PMID:20534551 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO palbociclib results in decreased expression of CDKN3 mRNA CTD PMID:22869556 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 decreases expression ISO palbociclib results in decreased expression of CDT1 mRNA CTD PMID:22869556 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659
JBrowse link
G Cenpa centromere protein A decreases expression ISO palbociclib results in decreased expression of CENPA mRNA CTD PMID:22869556 NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
JBrowse link
G Cenpe centromere protein E decreases expression ISO palbociclib results in decreased expression of CENPE mRNA CTD PMID:22869556 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
G Cenpf centromere protein F decreases expression ISO palbociclib results in decreased expression of CENPF mRNA CTD PMID:22869556 NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
JBrowse link
G Cenpm centromere protein M decreases expression ISO palbociclib results in decreased expression of CENPM mRNA CTD PMID:22869556 NCBI chr 7:113,748,026...113,759,296
Ensembl chr 7:113,747,516...113,764,258
JBrowse link
G Cep55 centrosomal protein 55 decreases expression ISO palbociclib results in decreased expression of CEP55 mRNA CTD PMID:22869556 NCBI chr 1:235,832,823...235,848,401
Ensembl chr 1:235,832,878...235,848,394
JBrowse link
G Ckap2l cytoskeleton associated protein 2-like decreases expression ISO palbociclib results in decreased expression of CKAP2L mRNA CTD PMID:22869556 NCBI chr 3:116,497,186...116,524,302
Ensembl chr 3:116,498,022...116,524,366
JBrowse link
G Cpa4 carboxypeptidase A4 increases expression ISO palbociclib results in increased expression of CPA4 mRNA CTD PMID:22869556 NCBI chr 4:59,188,284...59,212,255
Ensembl chr 4:59,188,284...59,212,255
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
ISO 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CTNNB1 protein] CTD PMID:22869556 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Dennd6b DENN domain containing 6B increases expression ISO palbociclib results in increased expression of DENND6B mRNA CTD PMID:22869556 NCBI chr 7:120,261,679...120,273,667
Ensembl chr 7:120,261,679...120,273,494
JBrowse link
G Depdc1b DEP domain containing 1B decreases expression ISO palbociclib results in decreased expression of DEPDC1B mRNA CTD PMID:22869556 NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779
JBrowse link
G Dlgap5 DLG associated protein 5 decreases expression ISO palbociclib results in decreased expression of DLGAP5 mRNA CTD PMID:22869556 NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
JBrowse link
G Donson DNA replication fork stabilization factor DONSON decreases expression ISO palbociclib results in decreased expression of DONSON mRNA CTD PMID:22869556 NCBI chr11:30,911,616...30,933,150
Ensembl chr11:30,923,239...30,932,889
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]] CTD PMID:22751436 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G E2f2 E2F transcription factor 2 multiple interactions
decreases expression
ISO E2F2 protein inhibits the reaction [palbociclib results in decreased expression of CCNA2 protein]; E2F2 protein inhibits the reaction [palbociclib results in decreased expression of RNR2 protein]; E2F2 protein inhibits the reaction [palbociclib results in decreased phosphorylation of RB1 protein]
palbociclib results in decreased expression of E2F2 mRNA
CTD PMID:20100483 PMID:20473330 PMID:22869556 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
JBrowse link
G Eln elastin increases expression ISO palbociclib results in increased expression of ELN protein CTD PMID:21880723 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Exo1 exonuclease 1 decreases expression ISO palbociclib results in decreased expression of EXO1 mRNA CTD PMID:22869556 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases expression ISO palbociclib results in decreased expression of EZH2 mRNA; palbociclib results in decreased expression of EZH2 protein CTD PMID:20948315 PMID:22869556 PMID:24736461 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO palbociclib results in increased expression of F3 mRNA CTD PMID:22869556 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fam111a FAM111 trypsin like peptidase A decreases expression ISO palbociclib results in decreased expression of FAM111A mRNA CTD PMID:22869556 NCBI chr 1:209,640,865...209,656,551
Ensembl chr 1:209,640,953...209,656,547
JBrowse link
G Fam83d family with sequence similarity 83, member D decreases expression ISO palbociclib results in decreased expression of FAM83D mRNA CTD PMID:22869556 NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192
JBrowse link
G Fance FA complementation group E decreases expression ISO palbociclib results in decreased expression of FANCE mRNA CTD PMID:28620137 NCBI chr20:6,369,416...6,386,631
Ensembl chr20:6,375,573...6,386,631
JBrowse link
G Fanci FA complementation group I decreases expression ISO palbociclib results in decreased expression of FANCI mRNA CTD PMID:22869556 NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640
JBrowse link
G Fbxo5 F-box protein 5 decreases expression ISO palbociclib results in decreased expression of FBXO5 mRNA CTD PMID:22869556 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
JBrowse link
G Fen1 flap structure-specific endonuclease 1 decreases expression ISO palbociclib results in decreased expression of FEN1 mRNA CTD PMID:22869556 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression
affects response to substance
decreases phosphorylation
multiple interactions
ISO palbociclib results in decreased expression of FLT3 mRNA; palbociclib results in decreased expression of FLT3 protein
FLT3 protein affects the susceptibility to palbociclib
palbociclib results in decreased phosphorylation of FLT3 protein
[FLT3 protein affects the susceptibility to palbociclib] which results in decreased expression of FLT3 protein
CTD PMID:27099147 NCBI chr12:7,623,658...7,699,474
Ensembl chr12:7,623,930...7,699,474
JBrowse link
G Foxm1 forkhead box M1 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [palbociclib results in decreased expression of FOXM1 protein]; CDH1 protein affects the reaction [palbociclib results in decreased expression of FOXM1 protein]; palbociclib results in decreased expression of and results in decreased activity of FOXM1 protein
palbociclib results in decreased expression of FOXM1 mRNA
CTD PMID:22094256 PMID:22869556 NCBI chr 4:161,639,561...161,652,012
Ensembl chr 4:161,638,816...161,650,684
JBrowse link
G Gins2 GINS complex subunit 2 decreases expression ISO palbociclib results in decreased expression of GINS2 mRNA CTD PMID:22869556 NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339
JBrowse link
G Gls glutaminase increases expression ISO palbociclib results in increased expression of GLS mRNA CTD PMID:28620137 NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
JBrowse link
G Gmnn geminin, DNA replication inhibitor decreases expression ISO palbociclib results in decreased expression of GMNN mRNA CTD PMID:22869556 NCBI chr17:40,301,771...40,310,054
Ensembl chr17:40,301,808...40,310,054
JBrowse link
G Gpsm2 G-protein signaling modulator 2 decreases expression ISO palbociclib results in decreased expression of GPSM2 mRNA CTD PMID:22869556 NCBI chr 2:196,327,149...196,375,322
Ensembl chr 2:196,327,149...196,375,154
JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO palbociclib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G H2ax H2A.X variant histone multiple interactions
decreases phosphorylation
ISO Doxorubicin inhibits the reaction [palbociclib results in decreased phosphorylation of H2AX protein]; palbociclib inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Carboplatin results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Doxorubicin results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Etoposide results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Paclitaxel results in increased expression of H2AX protein]; RB1 protein affects the reaction [palbociclib results in decreased phosphorylation of H2AX protein] CTD PMID:22302033 PMID:22751436 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G H4c3 H4 clustered histone 3 decreases expression ISO palbociclib results in decreased expression of H4C3 mRNA CTD PMID:22869556
G Hjurp Holliday junction recognition protein decreases expression ISO palbociclib results in decreased expression of HJURP mRNA CTD PMID:22869556 NCBI chr 9:88,853,379...88,867,730
Ensembl chr 9:88,853,386...88,867,728
JBrowse link
G Hmgb2 high mobility group box 2 decreases expression ISO palbociclib results in decreased expression of HMGB2 mRNA CTD PMID:22869556 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO palbociclib results in decreased expression of HMMR mRNA CTD PMID:22869556 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO [BMS 754807 co-treated with palbociclib] results in decreased phosphorylation of IGF1R protein CTD PMID:24986516 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Il20rb interleukin 20 receptor subunit beta increases expression ISO palbociclib results in increased expression of IL20RB mRNA CTD PMID:22869556 NCBI chr 8:100,979,085...101,010,829
Ensembl chr 8:100,980,383...101,009,942
JBrowse link
G Incenp inner centromere protein decreases expression ISO palbociclib results in decreased expression of INCENP mRNA CTD PMID:22869556 NCBI chr 1:206,520,655...206,550,575
Ensembl chr 1:206,523,380...206,553,265
JBrowse link
G Kif11 kinesin family member 11 decreases expression ISO palbociclib results in decreased expression of KIF11 mRNA CTD PMID:22869556 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
JBrowse link
G Kif14 kinesin family member 14 decreases expression ISO palbociclib results in decreased expression of KIF14 mRNA CTD PMID:22869556 NCBI chr13:47,926,975...47,990,598
Ensembl chr13:47,927,044...47,989,164
JBrowse link
G Kif15 kinesin family member 15 decreases expression ISO palbociclib results in decreased expression of KIF15 mRNA CTD PMID:22869556 NCBI chr 8:122,601,888...122,672,750
Ensembl chr 8:122,601,897...122,672,750
JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO palbociclib results in decreased expression of KIF20A mRNA CTD PMID:22869556 NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
JBrowse link
G Kif23 kinesin family member 23 decreases expression ISO palbociclib results in decreased expression of KIF23 mRNA CTD PMID:22869556 NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
JBrowse link
G Kif2c kinesin family member 2C decreases expression ISO palbociclib results in decreased expression of KIF2C mRNA CTD PMID:22869556 NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637
JBrowse link
G Kif4a kinesin family member 4A decreases expression ISO palbociclib results in decreased expression of KIF4A mRNA CTD PMID:22869556 NCBI chr  X:65,721,724...65,824,151
Ensembl chr  X:65,721,779...65,824,139
JBrowse link
G Kifc1 kinesin family member C1 decreases expression ISO palbociclib results in decreased expression of KIFC1 mRNA CTD PMID:22869556 NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105
JBrowse link
G Knstrn kinetochore-localized astrin/SPAG5 binding protein decreases expression ISO palbociclib results in decreased expression of KNSTRN mRNA CTD PMID:22869556 NCBI chr 3:105,800,762...105,820,555
Ensembl chr 3:105,800,954...105,820,715
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression ISO palbociclib results in decreased expression of KPNA2 mRNA CTD PMID:22869556 NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150
JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO palbociclib results in increased expression of LAMA3 mRNA CTD PMID:22869556 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353
JBrowse link
G Lamb3 laminin subunit beta 3 increases expression ISO palbociclib results in increased expression of LAMB3 mRNA CTD PMID:22869556 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO palbociclib results in increased expression of LAMC2 mRNA CTD PMID:22869556 NCBI chr13:65,284,664...65,344,200
Ensembl chr13:65,284,664...65,344,200
JBrowse link
G Lmnb1 lamin B1 decreases expression ISO palbociclib results in decreased expression of LMNB1 mRNA CTD PMID:22869556 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502
JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor decreases expression ISO palbociclib results in decreased expression of MCM10 mRNA CTD PMID:22869556 NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 multiple interactions
decreases expression
ISO RB1 protein affects the reaction [palbociclib results in decreased expression of MCM7 protein]
palbociclib results in decreased expression of MCM7 mRNA; palbociclib results in decreased expression of MCM7 protein
CTD PMID:20473330 PMID:22869556 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063
JBrowse link
G Mef2d myocyte enhancer factor 2D multiple interactions ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of MEF2D protein] CTD PMID:22094256 NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457
JBrowse link
G Melk maternal embryonic leucine zipper kinase decreases expression ISO palbociclib results in decreased expression of MELK mRNA CTD PMID:22869556 NCBI chr 5:58,540,393...58,600,937
Ensembl chr 5:58,540,449...58,600,937
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression
ISO Doxorubicin promotes the reaction [palbociclib results in decreased expression of MKI67 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of MKI67 protein] CTD PMID:15542782 PMID:22170262 PMID:22383795 PMID:22751436 PMID:23708653 More... NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mxd4 Max dimerization protein 4 increases expression ISO palbociclib results in increased expression of MXD4 mRNA CTD PMID:22869556 NCBI chr14:76,562,105...76,576,224
Ensembl chr14:76,561,774...76,576,221
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO palbociclib results in decreased expression of MYC protein CTD PMID:27099147 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ncapd2 non-SMC condensin I complex, subunit D2 decreases expression ISO palbociclib results in decreased expression of NCAPD2 mRNA CTD PMID:22869556 NCBI chr 4:157,968,814...157,992,314
Ensembl chr 4:157,968,815...157,992,020
JBrowse link
G Ncapg non-SMC condensin I complex, subunit G decreases expression ISO palbociclib results in decreased expression of NCAPG mRNA CTD PMID:22869556 NCBI chr14:65,404,235...65,432,902
Ensembl chr14:65,404,163...65,432,902
JBrowse link
G Ncapg2 non-SMC condensin II complex, subunit G2 decreases expression ISO palbociclib results in decreased expression of NCAPG2 mRNA CTD PMID:22869556 NCBI chr 6:137,342,449...137,418,083
Ensembl chr 6:137,342,943...137,415,159
JBrowse link
G Ndc80 NDC80 kinetochore complex component decreases expression ISO palbociclib results in decreased expression of NDC80 mRNA CTD PMID:22869556 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
JBrowse link
G Nek2 NIMA-related kinase 2 decreases expression ISO palbociclib results in decreased expression of NEK2 mRNA CTD PMID:22869556 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 decreases expression ISO palbociclib results in decreased expression of NUSAP1 mRNA CTD PMID:22869556 NCBI chr 3:106,603,273...106,633,624
Ensembl chr 3:106,603,289...106,633,624
JBrowse link
G Oip5 Opa interacting protein 5 decreases expression ISO palbociclib results in decreased expression of OIP5 mRNA CTD PMID:22869556 NCBI chr 3:106,593,746...106,603,281
Ensembl chr 3:106,593,760...106,603,250
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of PARP1 protein; palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]] CTD PMID:22751436 PMID:23676220 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pbk PDZ binding kinase decreases expression ISO palbociclib results in decreased expression of PBK mRNA CTD PMID:22869556 NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014
JBrowse link
G Pclaf PCNA clamp associated factor decreases expression ISO palbociclib results in decreased expression of PCLAF mRNA CTD PMID:22869556 NCBI chr 8:66,420,673...66,432,568
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO palbociclib results in decreased expression of PCNA mRNA; palbociclib results in decreased expression of PCNA protein CTD PMID:20473330 PMID:22869556 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]] CTD PMID:21880723 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Phf19 PHD finger protein 19 decreases expression ISO palbociclib results in decreased expression of PHF19 mRNA CTD PMID:22869556 NCBI chr 3:18,175,281...18,197,289
Ensembl chr 3:18,175,282...18,196,405
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase decreases expression ISO palbociclib results in decreased expression of PIM1 mRNA CTD PMID:27099147 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
JBrowse link
G Pimreg PICALM interacting mitotic regulator decreases expression ISO palbociclib results in decreased expression of PIMREG mRNA CTD PMID:22869556 NCBI chr10:56,669,603...56,674,540
Ensembl chr10:56,669,675...56,674,791
JBrowse link
G Plk1 polo-like kinase 1 decreases expression
multiple interactions
ISO palbociclib results in decreased expression of PLK1 mRNA
palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]]
CTD PMID:20100483 PMID:22869556 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit decreases expression ISO palbociclib results in decreased expression of POLA2 mRNA CTD PMID:22869556 NCBI chr 1:203,227,183...203,251,350
Ensembl chr 1:203,203,388...203,251,348
JBrowse link
G Pole2 DNA polymerase epsilon 2, accessory subunit decreases expression ISO palbociclib results in decreased expression of POLE2 mRNA CTD PMID:22869556 NCBI chr 6:87,674,702...87,712,723
Ensembl chr 6:87,674,702...87,699,305
JBrowse link
G Porcn porcupine O-acyltransferase increases expression ISO palbociclib results in increased expression of PORCN mRNA CTD PMID:22869556 NCBI chr  X:14,285,864...14,298,481
Ensembl chr  X:14,285,871...14,298,481
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO palbociclib results in decreased expression of PRC1 mRNA CTD PMID:22869556 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
JBrowse link
G Prim1 DNA primase subunit 1 decreases expression ISO palbociclib results in decreased expression of PRIM1 mRNA CTD PMID:22869556 NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526
JBrowse link
G Prr11 proline rich 11 decreases expression ISO palbociclib results in decreased expression of PRR11 mRNA CTD PMID:22869556 NCBI chr10:71,898,858...71,943,325
Ensembl chr10:71,901,202...71,921,012
JBrowse link
G Prss23 serine protease 23 increases expression ISO palbociclib results in increased expression of PRSS23 mRNA CTD PMID:22869556 NCBI chr 1:143,402,725...143,422,182
Ensembl chr 1:143,401,396...143,422,091
JBrowse link
G Psrc1 proline and serine rich coiled-coil 1 decreases expression ISO palbociclib results in decreased expression of PSRC1 mRNA CTD PMID:22869556 NCBI chr 2:196,022,361...196,026,874
Ensembl chr 2:196,022,361...196,026,874
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin decreases expression ISO palbociclib results in decreased expression of PTTG1 mRNA CTD PMID:22869556 PMID:28620137 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO palbociclib results in decreased expression of RACGAP1 mRNA CTD PMID:22869556 NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831
JBrowse link
G Rad51ap1 RAD51 associated protein 1 decreases expression ISO palbociclib results in decreased expression of RAD51AP1 mRNA CTD PMID:22869556 NCBI chr 4:159,759,454...159,772,524
Ensembl chr 4:159,759,459...159,772,524
JBrowse link
G Ranbp1 RAN binding protein 1 decreases expression ISO palbociclib results in decreased expression of RANBP1 mRNA CTD PMID:28620137 NCBI chr11:82,742,603...82,750,836
Ensembl chr11:82,742,600...82,750,838
JBrowse link
G Rb1 RB transcriptional corepressor 1 affects phosphorylation
decreases expression
increases response to substance
multiple interactions
affects response to substance
decreases response to substance
affects reaction
increases phosphorylation
decreases phosphorylation
ISO palbociclib affects the phosphorylation of RB1 protein
palbociclib results in decreased expression of RB1 mRNA; palbociclib results in decreased expression of RB1 protein
RB1 protein results in increased susceptibility to palbociclib
[CDKN2A gene mutant form results in increased susceptibility to palbociclib] which results in decreased phosphorylation of RB1 protein
RB1 protein affects the susceptibility to palbociclib
BMS 754807 promotes the reaction [palbociclib results in decreased phosphorylation of RB1 protein]; E2F2 protein inhibits the reaction [palbociclib results in decreased phosphorylation of RB1 protein]; palbociclib affects the reaction [RB1 mutant form results in increased expression of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]; palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]]; palbociclib inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased phosphorylation of RB1 protein]; palbociclib promotes the reaction [RB1 protein binds to CCNA2 promoter]; palbociclib promotes the reaction [RB1 protein binds to SP1 protein]; palbociclib results in decreased phosphorylation of and results in decreased expression of RB1 protein; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of CCNA2 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to RNR2 promoter]]; RB1 protein affects the reaction [palbociclib promotes the reaction [Cycloheximide results in decreased expression of RBL1 protein]]; RB1 protein affects the reaction [palbociclib results in decreased expression of CCNA2 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of MCM7 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of MKI67 protein]; RB1 protein affects the reaction [palbociclib results in decreased expression of RBL1 protein]; RB1 protein affects the reaction [palbociclib results in decreased phosphorylation of H2AX protein]; RB1 protein affects the reaction [palbociclib results in decreased phosphorylation of RB1 protein]
RB1 gene mutant form results in decreased susceptibility to palbociclib; RB1 mutant form results in decreased susceptibility to palbociclib
RB1 protein affects the reaction palbociclib
palbociclib results in increased phosphorylation of RB1 protein
CTD PMID:15542782 PMID:16690963 PMID:17537993 PMID:19435910 PMID:19874578 More... NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [palbociclib results in decreased expression of RBL1 protein]; palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]; palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]; palbociclib inhibits the reaction [RBL1 protein binds to RNR2 promoter]; palbociclib promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of RBL1 protein]; palbociclib promotes the reaction [Cycloheximide results in decreased expression of RBL1 protein]; palbociclib results in decreased phosphorylation of and results in decreased expression of RBL1 protein; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to CCNA2 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]]; RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to RNR2 promoter]]; RB1 protein affects the reaction [palbociclib promotes the reaction [Cycloheximide results in decreased expression of RBL1 protein]]; RB1 protein affects the reaction [palbociclib results in decreased expression of RBL1 protein]
palbociclib results in decreased expression of RBL1 mRNA; palbociclib results in decreased expression of RBL1 protein
CTD PMID:20100483 PMID:20473330 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions
decreases phosphorylation
ISO palbociclib affects the reaction [RB1 mutant form results in increased expression of RBL2 protein]; palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RBL2 protein]; palbociclib results in decreased phosphorylation of and results in increased expression of RBL2 protein; palbociclib results in increased expression of and results in increased stability of RBL2 protein
palbociclib results in decreased phosphorylation of RBL2 protein
CTD PMID:20100483 PMID:20473330 PMID:22094256 PMID:26174628 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
JBrowse link
G Rdh5 retinol dehydrogenase 5 increases expression ISO palbociclib results in increased expression of RDH5 mRNA CTD PMID:22869556 NCBI chr 7:1,340,545...1,347,361 JBrowse link
G Rfc5 replication factor C subunit 5 decreases expression ISO palbociclib results in decreased expression of RFC5 mRNA CTD PMID:22869556 NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312
JBrowse link
G Rps29 ribosomal protein S29 increases expression ISO palbociclib results in increased expression of RPS29 mRNA CTD PMID:22869556 NCBI chr 6:87,635,229...87,636,605
Ensembl chr 6:87,635,230...87,636,636
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO palbociclib promotes the reaction [BMS 754807 results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:24986516 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 decreases expression ISO palbociclib results in decreased expression of RRM1 mRNA CTD PMID:22869556 NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO palbociclib results in decreased expression of RRM2 mRNA CTD PMID:22869556 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Sapcd2 suppressor APC domain containing 2 decreases expression ISO palbociclib results in decreased expression of SAPCD2 mRNA CTD PMID:22869556 NCBI chr 3:8,186,089...8,195,119
Ensembl chr 3:8,187,266...8,192,546
JBrowse link
G Senp3 SUMO specific peptidase 3 multiple interactions ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein] CTD PMID:22094256 NCBI chr10:54,390,698...54,399,590
Ensembl chr10:54,390,694...54,399,593
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO palbociclib results in increased expression of SERPINE1 mRNA CTD PMID:22869556 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Shox2 short stature homeobox 2 multiple interactions ISO palbociclib inhibits the reaction [[CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of SHOX2 protein] CTD PMID:22094256 NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143
JBrowse link
G Slc16a4 solute carrier family 16, member 4 increases expression ISO palbociclib results in increased expression of SLC16A4 mRNA CTD PMID:22869556 NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117
JBrowse link
G Smc4 structural maintenance of chromosomes 4 decreases expression ISO palbociclib results in decreased expression of SMC4 mRNA CTD PMID:22869556 NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions
increases expression
ISO 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of SNAI2 protein] CTD PMID:22869556 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]]; palbociclib promotes the reaction [RB1 protein binds to SP1 protein] CTD PMID:21880723 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sparc secreted protein acidic and cysteine rich increases expression ISO palbociclib results in increased expression of SPARC mRNA CTD PMID:28620137 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
JBrowse link
G Spc24 SPC24 component of NDC80 kinetochore complex decreases expression ISO palbociclib results in decreased expression of SPC24 mRNA CTD PMID:22869556 NCBI chr 8:20,300,315...20,305,354
Ensembl chr 8:20,300,319...20,305,310
JBrowse link
G Spc25 SPC25 component of NDC80 kinetochore complex decreases expression ISO palbociclib results in decreased expression of SPC25 mRNA CTD PMID:22869556 NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959
JBrowse link
G Stil STIL, centriolar assembly protein decreases expression ISO palbociclib results in decreased expression of STIL mRNA CTD PMID:22869556 NCBI chr 5:128,520,837...128,573,732
Ensembl chr 5:128,520,953...128,573,730
JBrowse link
G Stmn1 stathmin 1 decreases expression ISO palbociclib results in decreased expression of STMN1 mRNA CTD PMID:22869556 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Tacc3 transforming, acidic coiled-coil containing protein 3 decreases expression ISO palbociclib results in decreased expression of TACC3 mRNA CTD PMID:28620137 NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases activity ISO palbociclib results in increased activity of TGFB1 protein CTD PMID:22869556 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO palbociclib analog results in decreased expression of TK1 mRNA; palbociclib results in decreased expression of TK1 mRNA; palbociclib results in decreased expression of TK1 protein CTD PMID:15542782 PMID:22170262 PMID:22869556 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
JBrowse link
G Tmpo thymopoietin decreases expression ISO palbociclib results in decreased expression of TMPO mRNA CTD PMID:22869556 NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727
JBrowse link
G Tmprss2 transmembrane serine protease 2 multiple interactions ISO palbociclib promotes the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA] CTD PMID:23708653 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Top1 DNA topoisomerase I decreases expression ISO palbociclib results in decreased expression of TOP1 mRNA CTD PMID:24549232 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression
multiple interactions
ISO palbociclib analog results in decreased expression of TOP2A mRNA; palbociclib results in decreased expression of TOP2A mRNA; palbociclib results in decreased expression of TOP2A protein
palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]]
CTD PMID:15542782 PMID:20948315 PMID:22751436 PMID:22869556 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tp53 tumor protein p53 decreases response to substance ISO TP53 protein mutant form results in decreased susceptibility to palbociclib CTD PMID:21278246 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpx2 TPX2, microtubule nucleation factor decreases expression ISO palbociclib results in decreased expression of TPX2 mRNA CTD PMID:22869556 NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468
JBrowse link
G Troap trophinin associated protein decreases expression ISO palbociclib results in decreased expression of TROAP mRNA CTD PMID:22869556 NCBI chr 7:130,233,534...130,242,369
Ensembl chr 7:130,234,544...130,242,365
JBrowse link
G Ttc14 tetratricopeptide repeat domain 14 increases expression ISO palbociclib results in increased expression of TTC14 mRNA CTD PMID:22869556 NCBI chr 2:116,653,543...116,665,072
Ensembl chr 2:116,653,595...116,664,158
JBrowse link
G Ttk Ttk protein kinase decreases expression ISO palbociclib results in decreased expression of TTK mRNA CTD PMID:22869556 NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651
JBrowse link
G Tubb4b tubulin, beta 4B class IVb decreases expression ISO palbociclib results in decreased expression of TUBB4B mRNA CTD PMID:22869556 NCBI chr 3:8,037,844...8,040,294
Ensembl chr 3:8,037,799...8,040,296
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO palbociclib results in decreased expression of TUBB mRNA CTD PMID:22869556 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Tyms thymidylate synthetase decreases expression ISO palbociclib results in decreased expression of TYMS mRNA; palbociclib results in decreased expression of TYMS protein CTD PMID:20948315 PMID:22869556 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO palbociclib results in decreased expression of UBE2C mRNA CTD PMID:22869556 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Ube2t ubiquitin-conjugating enzyme E2T decreases expression ISO palbociclib results in decreased expression of UBE2T mRNA CTD PMID:22869556 NCBI chr13:46,403,352...46,413,854
Ensembl chr13:46,403,375...46,414,835
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO palbociclib results in decreased expression of UHRF1 mRNA CTD PMID:22869556 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
JBrowse link
G Vim vimentin increases expression ISO palbociclib results in increased expression of VIM protein CTD PMID:22869556 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions ISO palbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein] CTD PMID:22094256 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
JBrowse link
G Zwint ZW10 interacting kinetochore protein decreases expression ISO palbociclib results in decreased expression of ZWINT mRNA CTD PMID:22869556 NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            antineoplastic agent 17317
              palbociclib 176
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        aromatic amine 13704
                                          aminopyridine 366
                                            palbociclib 176
paths to the root