Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4beta-hydroxycholesterol
go back to main search page
Accession:CHEBI:85778 term browser browse the term
Definition:A oxysterol that is cholesterol in which the hydrogen at the 4beta position has been replaced by a hydroxy group. A metabolite of cholesterol formed by the drug-metabolizing enzyme cytochrome P450 3A4, it is one of the major oxysterols in the human circulation.
Synonyms:exact_synonym: cholest-5-ene-3beta,4beta-diol
 related_synonym: (3beta,4beta)-cholest-5-ene-3,4-diol;   Formula=C27H46O2;   InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3/t18-,19+,20-,21+,22+,24+,25-,26-,27-/m1/s1;   InChIKey=CZDKQKOAHAICSF-JSAMMMMSSA-N;   SMILES=CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4[C@@H](O)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C;   cholest-5-en-3beta,4beta-diol
 xref: CAS:17320-10-4;   HMDB:HMDB0013643;   LIPID_MAPS_instance:LMST01010014
 xref_mesh: MESH:C099828
 xref: PMID:11514559;   PMID:12077124;   PMID:18279471;   PMID:18300941;   PMID:19006545;   PMID:19458613;   PMID:21728364;   PMID:8656065


show annotations for term's descendants           Sort by:
 
4beta-hydroxycholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases chemical synthesis
ISO [CYP3A4 protein results in increased oxidation of Cholesterol] which results in increased chemical synthesis of cholest-5-ene-3,4-diol
CYP3A4 protein results in increased chemical synthesis of cholest-5-ene-3,4-diol
CTD PMID:11514559 PMID:19954708 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            eukaryotic metabolite 19052
              algal metabolite 13939
                cholesterol 334
                  4beta-hydroxycholesterol 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic polycyclic compound 16538
                                  steroid 13057
                                    hydroxy steroid 12658
                                      3-hydroxy steroid 10368
                                        3beta-hydroxy steroid 2014
                                          3beta-hydroxy-Delta(5)-steroid 1849
                                            cholesterol 334
                                              oxysterol 106
                                                4beta-hydroxycholesterol 1
paths to the root