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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:satraplatin
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Accession:CHEBI:85609 term browser browse the term
Definition:A platinum coordination entity that consists of a central platunum atom bound to chloro (x2), acetate (x2), amino, and cyclohexylamino groups. Used for treatment of advanced prostate cancer.
Synonyms:exact_synonym: bis(acetato-kappaO)(ammine)dichloro(cyclohexanamine)platinum
 related_synonym: BMY-45594;   Bis-acetatoamminedichlorocyclohexylamine platinum(IV);   Formula=C10H22Cl2N2O4Pt;   InChI=1S/C6H13N.2C2H4O2.2ClH.H3N.Pt/c7-6-4-2-1-3-5-6;2*1-2(3)4;;;;/h6H,1-5,7H2;2*1H3,(H,3,4);2*1H;1H3;/q;;;;;;+4/p-4;   InChIKey=CKNPWBAXEKSCRG-UHFFFAOYSA-J;   JM-216;   JM216;   SMILES=CC(=O)O[Pt--]([NH3+])(Cl)(Cl)([NH2+]C1CCCCC1)OC(C)=O
 xref: CAS:129580-63-8;   KEGG:D05807
 xref_mesh: MESH:C081294
 xref: PMID:21481618;   PMID:22643969;   PMID:23429330;   PMID:23433892;   PMID:23684781;   PMID:25382189;   PMID:25435590;   PMID:25556988;   PMID:9658208;   Reaxys:22320762;   Wikipedia:Satraplatin


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satraplatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha decreases response to substance ISO ATP7A protein results in decreased susceptibility to satraplatin metabolite CTD PMID:16170571 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atp7b ATPase copper transporting beta decreases response to substance ISO ATP7B protein results in decreased susceptibility to satraplatin metabolite CTD PMID:16170571 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO satraplatin results in decreased activity of CYP2C8 protein CTD PMID:24882083 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO satraplatin results in decreased activity of CYP2E1 protein CTD PMID:24882083 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO satraplatin results in decreased activity of CYP3A4 protein CTD PMID:24882083 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      application 19411
        pharmaceutical 19299
          drug 19299
            antineoplastic agent 17257
              satraplatin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  metal atom 17283
                    transition element atom 16744
                      d-block element atom 16735
                        nickel group element atom 10173
                          platinum 8440
                            platinum molecular entity 8440
                              platinum coordination entity 8440
                                satraplatin 5
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