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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:satraplatin
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Accession:CHEBI:85609 term browser browse the term
Definition:A platinum coordination entity that consists of a central platunum atom bound to chloro (x2), acetate (x2), amino, and cyclohexylamino groups. Used for treatment of advanced prostate cancer.
Synonyms:exact_synonym: bis(acetato-kappaO)(ammine)dichloro(cyclohexanamine)platinum
 related_synonym: BMY-45594;   Bis-acetatoamminedichlorocyclohexylamine platinum(IV);   Formula=C10H22Cl2N2O4Pt;   InChI=1S/C6H13N.2C2H4O2.2ClH.H3N.Pt/c7-6-4-2-1-3-5-6;2*1-2(3)4;;;;/h6H,1-5,7H2;2*1H3,(H,3,4);2*1H;1H3;/q;;;;;;+4/p-4;   InChIKey=CKNPWBAXEKSCRG-UHFFFAOYSA-J;   JM-216;   JM216;   SMILES=CC(=O)O[Pt--]([NH3+])(Cl)(Cl)([NH2+]C1CCCCC1)OC(C)=O
 xref: CAS:129580-63-8;   KEGG:D05807
 xref_mesh: MESH:C081294
 xref: PMID:21481618;   PMID:22643969;   PMID:23429330;   PMID:23433892;   PMID:23684781;   PMID:25382189;   PMID:25435590;   PMID:25556988;   PMID:9658208;   Reaxys:22320762;   Wikipedia:Satraplatin



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satraplatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha decreases response to substance ISO ATP7A protein results in decreased susceptibility to satraplatin metabolite CTD PMID:16170571 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Atp7b ATPase copper transporting beta decreases response to substance ISO ATP7B protein results in decreased susceptibility to satraplatin metabolite CTD PMID:16170571 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO satraplatin results in decreased activity of CYP2C8 protein CTD PMID:24882083
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO satraplatin results in decreased activity of CYP2E1 protein CTD PMID:24882083 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO satraplatin results in decreased activity of CYP3A4 protein CTD PMID:24882083 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            antineoplastic agent 17359
              satraplatin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  metal atom 17430
                    transition element atom 16845
                      d-block element atom 16836
                        nickel group element atom 10187
                          platinum 8460
                            platinum molecular entity 8460
                              platinum coordination entity 8460
                                satraplatin 5
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