Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:satraplatin
go back to main search page
Accession:CHEBI:85609 term browser browse the term
Definition:A platinum coordination entity that consists of a central platunum atom bound to chloro (x2), acetate (x2), amino, and cyclohexylamino groups. Used for treatment of advanced prostate cancer.
Synonyms:exact_synonym: bis(acetato-kappaO)(ammine)dichloro(cyclohexanamine)platinum
 related_synonym: BMY-45594;   Bis-acetatoamminedichlorocyclohexylamine platinum(IV);   Formula=C10H22Cl2N2O4Pt;   InChI=1S/C6H13N.2C2H4O2.2ClH.H3N.Pt/c7-6-4-2-1-3-5-6;2*1-2(3)4;;;;/h6H,1-5,7H2;2*1H3,(H,3,4);2*1H;1H3;/q;;;;;;+4/p-4;   InChIKey=CKNPWBAXEKSCRG-UHFFFAOYSA-J;   JM-216;   JM216;   SMILES=CC(=O)O[Pt--]([NH3+])(Cl)(Cl)([NH2+]C1CCCCC1)OC(C)=O
 xref: CAS:129580-63-8;   KEGG:D05807
 xref_mesh: MESH:C081294
 xref: PMID:21481618;   PMID:22643969;   PMID:23429330;   PMID:23433892;   PMID:23684781;   PMID:25382189;   PMID:25435590;   PMID:25556988;   PMID:9658208;   Reaxys:22320762;   Wikipedia:Satraplatin


show annotations for term's descendants           Sort by:
 
satraplatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha decreases response to substance ISO ATP7A protein results in decreased susceptibility to satraplatin metabolite CTD PMID:16170571 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atp7b ATPase copper transporting beta decreases response to substance ISO ATP7B protein results in decreased susceptibility to satraplatin metabolite CTD PMID:16170571 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO satraplatin results in decreased activity of CYP2C8 protein CTD PMID:24882083 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO satraplatin results in decreased activity of CYP2E1 protein CTD PMID:24882083 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO satraplatin results in decreased activity of CYP3A4 protein CTD PMID:24882083 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      application 19505
        pharmaceutical 19375
          drug 19375
            antineoplastic agent 17034
              satraplatin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  metal atom 17316
                    transition element atom 16775
                      d-block element atom 16766
                        nickel group element atom 10181
                          platinum 8447
                            platinum molecular entity 8447
                              platinum coordination entity 8447
                                satraplatin 5
paths to the root