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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flumequine
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Accession:CHEBI:85267 term browser browse the term
Definition:A racemate comprising equimolar amounts of R- and S-flumequine. A broad-spectrum antibiotic, formerly used in veterinary medicine for stock breeding and treatment of aquacultures.
Synonyms:exact_synonym: rac-9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid
 related_synonym: 9-Fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid;   flumequino;   flumequinum
 xref: CAS:42835-25-6;   KEGG:D02302
 xref_mesh: MESH:C012976
 xref: PMID:23773949;   PMID:24261869;   PMID:24836135;   PMID:25045079;   PMID:25476307;   PMID:25633214;   Reaxys:490724;   VSDB:1564;   Wikipedia:Flumequine


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flumequine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL2 mRNA CTD PMID:23681119 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL3 C-C motif chemokine ligand 3 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL3 mRNA CTD PMID:23681119 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL4 mRNA CTD PMID:23681119 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621 		JBrowse link
G CCL7 C-C motif chemokine ligand 7 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL7 mRNA CTD PMID:23681119 NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242 		JBrowse link
G CCNA2 cyclin A2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNA2 mRNA CTD PMID:23681119 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCNB1 cyclin B1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNB1 mRNA; flumequine promotes the reaction [estragole results in increased expression of CCNB1 mRNA] CTD PMID:23681119 PMID:31029721 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCNB2 cyclin B2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNB2 mRNA CTD PMID:23681119 NCBI chr15:59,105,146...59,125,045
Ensembl chr15:59,105,126...59,125,045 		JBrowse link
G CCND1 cyclin D1 multiple interactions
increases expression		 ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCND1 mRNA
flumequine results in increased expression of CCND1 mRNA		 CTD PMID:23681119 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCNE1 cyclin E1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNE1 mRNA; [flumequine co-treated with estragole] results in increased expression of CCNE1 mRNA CTD PMID:23681119 PMID:31029721 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCR2 mRNA CTD PMID:23681119 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940 		JBrowse link
G CCR7 C-C motif chemokine receptor 7 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCR7 mRNA CTD PMID:23681119 NCBI chr17:40,553,769...40,565,472
Ensembl chr17:40,553,769...40,565,472 		JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CDK1 mRNA CTD PMID:23681119 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CHEK1 checkpoint kinase 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CHEK1 mRNA CTD PMID:23681119 NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A1 mRNA CTD PMID:23681119 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A2 mRNA; [flumequine co-treated with estragole] results in increased expression of CYP1A2 mRNA CTD PMID:23681119 PMID:31029721 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP2B10 mRNA CTD PMID:23681119 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP7B1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of CYP7B1 mRNA CTD PMID:23681119 NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737 		JBrowse link
G EXO1 exonuclease 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of EXO1 mRNA CTD PMID:23681119 NCBI chr 1:241,847,986...241,889,939
Ensembl chr 1:241,847,967...241,895,148 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of FOS mRNA CTD PMID:23681119 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of IL1B mRNA CTD PMID:23681119 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL36B interleukin 36 beta multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of IL36B mRNA CTD PMID:23681119 NCBI chr 2:113,022,089...113,052,867
Ensembl chr 2:113,022,089...113,052,867 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of JUN mRNA CTD PMID:23681119 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G NFKB2 nuclear factor kappa B subunit 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NFKB2 mRNA CTD PMID:23681119 NCBI chr10:102,394,110...102,402,529
Ensembl chr10:102,394,110...102,402,524 		JBrowse link
G RAD18 RAD18 E3 ubiquitin protein ligase multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD18 mRNA CTD PMID:23681119 NCBI chr 3:8,877,075...8,963,472
Ensembl chr 3:8,775,402...8,963,773 		JBrowse link
G RAD51 RAD51 recombinase multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD51 mRNA CTD PMID:23681119 NCBI chr15:40,694,733...40,732,340
Ensembl chr15:40,694,774...40,732,340 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression		 ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of TNF mRNA; [flumequine co-treated with estragole] results in increased expression of TNF mRNA
flumequine results in increased expression of TNF mRNA		 CTD PMID:23681119 PMID:31029721 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 decreases expression
multiple interactions		 ISO flumequine results in decreased expression of UGT1A1 mRNA
[flumequine co-treated with estragole] results in decreased expression of UGT1A1 mRNA		 CTD PMID:23681119 PMID:31029721 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 decreases expression
multiple interactions		 ISO flumequine results in decreased expression of UGT2B1 mRNA
[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of UGT2B1 mRNA		 CTD PMID:23681119 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        antimicrobial agent 21890
          flumequine 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            heteroorganic entity 24766
                              organochalcogen compound 24378
                                organooxygen compound 24054
                                  carbon oxoacid 22749
                                    carboxylic acid 22729
                                      monocarboxylic acid 21724
                                        oxo monocarboxylic acid 6572
                                          3-oxo monocarboxylic acid 230
                                            9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid 28
                                              (S)-flumequine 28
                                                flumequine 28
paths to the root